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Bergman, Richard N

Title(s)Professor-in-Residence, Medicine
SchoolEndocrinology
Phone3104234634
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    Collapse Research 
    Collapse Research Activities and Funding
    IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    NIH/NHLBI R01HL060931Aug 15, 1999 - Jul 31, 2004
    Role: Principal Investigator
    INSULIN-DEPRIVED DIABETIC PANCREATIC VENOUS DIVERSION
    NIH/FIC R03TW000362Sep 30, 1993 - Sep 29, 1996
    Role: Principal Investigator
    INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS)
    NIH/NHLBI U01HL047890Sep 30, 1991 - Sep 29, 1995
    Role: Principal Investigator
    TRAINING IN SYSTEMS PHYSIOLOGY
    NIH/NIGMS T32GM008017Sep 22, 1982 - Jun 30, 1987
    Role: Principal Investigator
    Quantitation of Factors Regulating Glucose Tolerance
    NIH/NIDDK R01DK029867Aug 1, 1981 - Nov 30, 2009
    Role: Principal Investigator
    QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    NIH/NIADDK R01AM029867Aug 1, 1981 - Nov 30, 1987
    Role: Principal Investigator
    Quantitative Studies of Metabolic Organ Dynamics
    NIH/NIDDK R37DK027619Feb 1, 1980 - Nov 30, 2011
    Role: Principal Investigator
    QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICS
    NIH/NIDDK R01DK027619Feb 1, 1980 - Nov 30, 1996
    Role: Principal Investigator
    QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICS
    NIH/NIADDK R01AM027619Feb 1, 1980 - Jul 31, 1986
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Brouwer A, Asare Bediako I, Paszkiewicz RL, Kolka CM, Bergman RN, Broussard JL. Impact of sleep deprivation and high-fat feeding on insulin sensitivity and beta cell function in dogs. Diabetologia. 2020 Apr; 63(4):875-884. PMID: 32016566.
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    2. O'Mara AE, Johnson JW, Linderman JD, Brychta RJ, McGehee S, Fletcher LA, Fink YA, Kapuria D, Cassimatis TM, Kelsey N, Cero C, Abdul-Sater Z, Piccinini F, Baskin AS, Leitner BP, Cai H, Millo CM, Dieckmann W, Walter M, Javitt NB, Rotman Y, Walter PJ, Ader M, Bergman RN, Herscovitch P, Chen KY, Cypess AM. Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity. J Clin Invest. 2020 Jan 21. PMID: 31961826.
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    3. Woolcott OO, Bergman RN. Defining cutoffs to diagnose obesity using the relative fat mass (RFM): Association with mortality in NHANES 1999-2014. Int J Obes (Lond). 2020 Jan 07. PMID: 31911664.
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    4. Woolcott OO, Bergman RN. Relative Fat Mass as an estimator of whole-body fat percentage among children and adolescents: A cross-sectional study using NHANES. Sci Rep. 2019 Oct 24; 9(1):15279. PMID: 31649287.
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    5. Bergman RN, Piccinini F, Kabir M, Kolka CM, Ader M. Erratum. Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes. Diabetes 2019;68:1709-1716. Diabetes. 2019 Dec; 68(12):2350. PMID: 31597638.
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    6. Bergman RN, Piccinini F, Kabir M, Kolka CM, Ader M. Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes. Diabetes. 2019 09; 68(9):1709-1716. PMID: 31431441.
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    7. Iyer MS, Paszkiewicz RL, Bergman RN, Richey JM, Woolcott OO, Asare-Bediako I, Wu Q, Kim SP, Stefanovski D, Kolka CM, Clegg DJ, Kabir M. Activation of NPRs and UCP1-independent pathway following CB1R antagonist treatment is associated with adipose tissue beiging in fat-fed male dogs. Am J Physiol Endocrinol Metab. 2019 Sep 01; 317(3):E535-E547. PMID: 31237449.
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    8. Bergman RN, Piccinini F, Kabir M, Ader M. Novel aspects of the role of the liver in carbohydrate metabolism. Metabolism. 2019 10; 99:119-125. PMID: 31158368.
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    9. Muta K, Matsen ME, Acharya NK, Stefanovski D, Bergman RN, Schwartz MW, Morton GJ. Glucoregulatory responses to hypothalamic preoptic area cooling. Brain Res. 2019 05 01; 1710:136-145. PMID: 30610874.
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    10. Scarlett JM, Muta K, Brown JM, Rojas JM, Matsen ME, Acharya NK, Secher A, Ingvorsen C, Jorgensen R, Høeg-Jensen T, Stefanovski D, Bergman RN, Piccinini F, Kaiyala KJ, Shiota M, Morton GJ, Schwartz MW. Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain. Diabetes. 2019 03; 68(3):654-664. PMID: 30523024.
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    11. Piccinini F, Polidori DC, Gower BA, Fernandez JR, Bergman RN. Dissection of hepatic versus extra-hepatic insulin clearance: Ethnic differences in childhood. Diabetes Obes Metab. 2018 12; 20(12):2869-2875. PMID: 30019375.
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    12. Woolcott OO, Bergman RN. Relative fat mass (RFM) as a new estimator of whole-body fat percentage - A cross-sectional study in American adult individuals. Sci Rep. 2018 Jul 20; 8(1):10980. PMID: 30030479.
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    13. Bergman RN, Piccinini F, Asare Bediako I, Kabir M, Kolka C, Polidori D, Ader M. Quantitative path to deep phenotyping: Possible importance of reduced hepatic insulin degradation to type 2 diabetes mellitus pathogenesis. J Diabetes. 2018 Oct; 10(10):778-783. PMID: 29961982.
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    14. Asare-Bediako I, Paszkiewicz RL, Kim SP, Woolcott OO, Kolka CM, Burch MA, Kabir M, Bergman RN. Variability of Directly Measured First-Pass Hepatic Insulin Extraction and Its Association With Insulin Sensitivity and Plasma Insulin. Diabetes. 2018 08; 67(8):1495-1503. PMID: 29752425.
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    15. Palmer ND, Okut H, Hsu FC, Ng MCY, Chen YI, Goodarzi MO, Taylor KD, Norris JM, Lorenzo C, Rotter JI, Bergman RN, Langefeld CD, Wagenknecht LE, Bowden DW. Metabolomics Identifies Distinctive Metabolite Signatures for Measures of Glucose Homeostasis: The Insulin Resistance Atherosclerosis Family Study (IRAS-FS). J Clin Endocrinol Metab. 2018 05 01; 103(5):1877-1888. PMID: 29546329.
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    16. Asare-Bediako I, Paszkiewicz RL, Kim SP, Woolcott OO, Kolka CM, Burch M, Kabir M, Piccinini F, Bergman RN. Assessment of hepatic insulin extraction from in vivo surrogate methods of insulin clearance measurement. Am J Physiol Endocrinol Metab. 2018 10 01; 315(4):E605-E612. PMID: 29509434.
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    17. Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SCJ, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MCY, Palmer ND, Balkau B, Stancáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JMM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VKL, Park KS, Saleheen D, So WY, Tam CHT, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA, Thameem F, Wilson G, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney ASF, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, de Angelis MH, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CNA, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JCN, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RCW, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJF, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Mohlke KL, Meitinger T, Groop L, Abecasis G, Scott LJ, Morris AP, Kang HM, Altshuler D, Burtt NP, Florez JC, Boehnke M, McCarthy MI. Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data. 2018 01 23; 5:180002. PMID: 29360107.
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    18. Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SCJ, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MCY, Palmer ND, Balkau B, Stancáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JMM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VKL, Park KS, Saleheen D, So WY, Tam CHT, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA, Thameem F, Wilson G, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney ASF, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, de Angelis MH, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CNA, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RCW, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJF, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Mohlke KL, Meitinger T, Groop L, Abecasis G, Scott LJ, Morris AP, Kang HM, Altshuler D, Burtt NP, Florez JC, Boehnke M, McCarthy MI. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data. 2017 12 19; 4:170179. PMID: 29257133.
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    19. Broussard JL, Bergman RN, Bediako IA, Paszkiewicz RL, Iyer MS, Kolka CM. Insulin Access to Skeletal Muscle is Preserved in Obesity Induced by Polyunsaturated Diet. Obesity (Silver Spring). 2018 01; 26(1):119-125. PMID: 29193779.
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    20. Schüler R, Osterhoff MA, Frahnow T, Möhlig M, Spranger J, Stefanovski D, Bergman RN, Xu L, Seltmann AC, Kabisch S, Hornemann S, Kruse M, Pfeiffer AFH. Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes. Sci Rep. 2017 08 23; 7(1):9234. PMID: 28835639.
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    21. Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renström F, Quaye L, Eicher JD, Hayes JE, Cornelis M, Kutalik Z, Lim E, Luan J, Huffman JE, Zhang W, Zhao W, Griffin PJ, Haller T, Ahmad S, Marques-Vidal PM, Bien S, Yengo L, Teumer A, Smith AV, Kumari M, Harder MN, Justesen JM, Kleber ME, Hollensted M, Lohman K, Rivera NV, Whitfield JB, Zhao JH, Stringham HM, Lyytikäinen LP, Huppertz C, Willemsen G, Peyrot WJ, Wu Y, Kristiansson K, Demirkan A, Fornage M, Hassinen M, Bielak LF, Cadby G, Tanaka T, Mägi R, van der Most PJ, Jackson AU, Bragg-Gresham JL, Vitart V, Marten J, Navarro P, Bellis C, Pasko D, Johansson Å, Snitker S, Cheng YC, Eriksson J, Lim U, Aadahl M, Adair LS, Amin N, Balkau B, Auvinen J, Beilby J, Bergman RN, Bergmann S, Bertoni AG, Blangero J, Bonnefond A, Bonnycastle LL, Borja JB, Brage S, Busonero F, Buyske S, Campbell H, Chines PS, Collins FS, Corre T, Smith GD, Delgado GE, Dueker N, Dörr M, Ebeling T, Eiriksdottir G, Esko T, Faul JD, Fu M, Færch K, Gieger C, Gläser S, Gong J, Gordon-Larsen P, Grallert H, Grammer TB, Grarup N, van Grootheest G, Harald K, Hastie ND, Havulinna AS, Hernandez D, Hindorff L, Hocking LJ, Holmens OL, Holzapfel C, Hottenga JJ, Huang J, Huang T, Hui J, Huth C, Hutri-Kähönen N, James AL, Jansson JO, Jhun MA, Juonala M, Kinnunen L, Koistinen HA, Kolcic I, Komulainen P, Kuusisto J, Kvaløy K, Kähönen M, Lakka TA, Launer LJ, Lehne B, Lindgren CM, Lorentzon M, Luben R, Marre M, Milaneschi Y, Monda KL, Montgomery GW, De Moor MHM, Mulas A, Müller-Nurasyid M, Musk AW, Männikkö R, Männistö S, Narisu N, Nauck M, Nettleton JA, Nolte IM, Oldehinkel AJ, Olden M, Ong KK, Padmanabhan S, Paternoster L, Perez J, Perola M, Peters A, Peters U, Peyser PA, Prokopenko I, Puolijoki H, Raitakari OT, Rankinen T, Rasmussen-Torvik LJ, Rawal R, Ridker PM, Rose LM, Rudan I, Sarti C, Sarzynski MA, Savonen K, Scott WR, Sanna S, Shuldiner AR, Sidney S, Silbernagel G, Smith BH, Smith JA, Snieder H, Stancáková A, Sternfeld B, Swift AJ, Tammelin T, Tan ST, Thorand B, Thuillier D, Vandenput L, Vestergaard H, van Vliet-Ostaptchouk JV, Vohl MC, Völker U, Waeber G, Walker M, Wild S, Wong A, Wright AF, Zillikens MC, Zubair N, Haiman CA, Lemarchand L, Gyllensten U, Ohlsson C, Hofman A, Rivadeneira F, Uitterlinden AG, Pérusse L, Wilson JF, Hayward C, Polasek O, Cucca F, Hveem K, Hartman CA, Tönjes A, Bandinelli S, Palmer LJ, Kardia SLR, Rauramaa R, Sørensen TIA, Tuomilehto J, Salomaa V, Penninx BWJH, de Geus EJC, Boomsma DI, Lehtimäki T, Mangino M, Laakso M, Bouchard C, Martin NG, Kuh D, Liu Y, Linneberg A, März W, Strauch K, Kivimäki M, Harris TB, Gudnason V, Völzke H, Qi L, Järvelin MR, Chambers JC, Kooner JS, Froguel P, Kooperberg C, Vollenweider P, Hallmans G, Hansen T, Pedersen O, Metspalu A, Wareham NJ, Langenberg C, Weir DR, Porteous DJ, Boerwinkle E, Chasman DI, Abecasis GR, Barroso I, McCarthy MI, Frayling TM, O'Connell JR, van Duijn CM, Boehnke M, Heid IM, Mohlke KL, Strachan DP, Fox CS, Liu CT, Hirschhorn JN, Klein RJ, Johnson AD, Borecki IB, Franks PW, North KE, Cupples LA, Loos RJF, Kilpeläinen TO. Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet. 2017 Aug; 13(8):e1006972. PMID: 28832619.
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    22. Piccinini F, Polidori DC, Gower BA, Bergman RN. Hepatic but Not Extrahepatic Insulin Clearance Is Lower in African American Than in European American Women. Diabetes. 2017 10; 66(10):2564-2570. PMID: 28710139.
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    23. Bergman RN, Iyer MS. Indirect Regulation of Endogenous Glucose Production by Insulin: The Single Gateway Hypothesis Revisited. Diabetes. 2017 07; 66(7):1742-1747. PMID: 28637826.
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    24. Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH, Johnson AD, Eicher JD, Jackson AU, Ferreira T, Lee Y, Ma C, Steinthorsdottir V, Thorleifsson G, Qi L, Van Zuydam NR, Mahajan A, Chen H, Almgren P, Voight BF, Grallert H, Müller-Nurasyid M, Ried JS, Rayner NW, Robertson N, Karssen LC, van Leeuwen EM, Willems SM, Fuchsberger C, Kwan P, Teslovich TM, Chanda P, Li M, Lu Y, Dina C, Thuillier D, Yengo L, Jiang L, Sparso T, Kestler HA, Chheda H, Eisele L, Gustafsson S, Frånberg M, Strawbridge RJ, Benediktsson R, Hreidarsson AB, Kong A, Sigurðsson G, Kerrison ND, Luan J, Liang L, Meitinger T, Roden M, Thorand B, Esko T, Mihailov E, Fox C, Liu CT, Rybin D, Isomaa B, Lyssenko V, Tuomi T, Couper DJ, Pankow JS, Grarup N, Have CT, Jørgensen ME, Jørgensen T, Linneberg A, Cornelis MC, van Dam RM, Hunter DJ, Kraft P, Sun Q, Edkins S, Owen KR, Perry JRB, Wood AR, Zeggini E, Tajes-Fernandes J, Abecasis GR, Bonnycastle LL, Chines PS, Stringham HM, Koistinen HA, Kinnunen L, Sennblad B, Mühleisen TW, Nöthen MM, Pechlivanis S, Baldassarre D, Gertow K, Humphries SE, Tremoli E, Klopp N, Meyer J, Steinbach G, Wennauer R, Eriksson JG, M?nnistö S, Peltonen L, Tikkanen E, Charpentier G, Eury E, Lobbens S, Gigante B, Leander K, McLeod O, Bottinger EP, Gottesman O, Ruderfer D, Blüher M, Kovacs P, Tonjes A, Maruthur NM, Scapoli C, Erbel R, Jöckel KH, Moebus S, de Faire U, Hamsten A, Stumvoll M, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, Ripatti S, Salomaa V, Pedersen NL, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, Hansen T, Pedersen O, Barroso I, Lannfelt L, Ingelsson E, Lind L, Lindgren CM, Cauchi S, Froguel P, Loos RJF, Balkau B, Boeing H, Franks PW, Barricarte Gurrea A, Palli D, van der Schouw YT, Altshuler D, Groop LC, Langenberg C, Wareham NJ, Sijbrands E, van Duijn CM, Florez JC, Meigs JB, Boerwinkle E, Gieger C, Strauch K, Metspalu A, Morris AD, Palmer CNA, Hu FB, Thorsteinsdottir U, Stefansson K, Dupuis J, Morris AP, Boehnke M, McCarthy MI, Prokopenko I. An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes. 2017 11; 66(11):2888-2902. PMID: 28566273.
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    25. Wood AR, Jonsson A, Jackson AU, Wang N, van Leewen N, Palmer ND, Kobes S, Deelen J, Boquete-Vilarino L, Paananen J, Stancáková A, Boomsma DI, de Geus EJC, Eekhoff EMW, Fritsche A, Kramer M, Nijpels G, Simonis-Bik A, van Haeften TW, Mahajan A, Boehnke M, Bergman RN, Tuomilehto J, Collins FS, Mohlke KL, Banasik K, Groves CJ, McCarthy MI, Pearson ER, Natali A, Mari A, Buchanan TA, Taylor KD, Xiang AH, Gjesing AP, Grarup N, Eiberg H, Pedersen O, Chen YD, Laakso M, Norris JM, Smith U, Wagenknecht LE, Baier L, Bowden DW, Hansen T, Walker M, Watanabe RM, 't Hart LM, Hanson RL, Frayling TM. A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. Diabetes. 2017 08; 66(8):2296-2309. PMID: 28490609.
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    161. Sale MM, Hsu FC, Palmer ND, Gordon CJ, Keene KL, Borgerink HM, Sharma AJ, Bergman RN, Taylor KD, Saad MF, Norris JM. The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study. BMC Endocr Disord. 2007 Mar 30; 7:1. PMID: 17397545.
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    165. Cruz ML, Weigensberg MJ, Bergman RN, Goran MI. Frequency of hypoglycaemia during the intravenous glucose tolerance test in overweight children. Int J Pediatr Obes. 2007; 2(2):122-5. PMID: 17763019.
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    166. Willer CJ, Bonnycastle LL, Conneely KN, Duren WL, Jackson AU, Scott LJ, Narisu N, Chines PS, Skol A, Stringham HM, Petrie J, Erdos MR, Swift AJ, Enloe ST, Sprau AG, Smith E, Tong M, Doheny KF, Pugh EW, Watanabe RM, Buchanan TA, Valle TT, Bergman RN, Tuomilehto J, Mohlke KL, Collins FS, Boehnke M. Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. Diabetes. 2007 Jan; 56(1):256-64. PMID: 17192490.
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    168. Shtir C, Nagakawa IS, Duren WL, Conneely KN, Scott LJ, Silander K, Valle TT, Tuomilehto J, Buchanan TA, Bergman RN, Collins FS, Boehnke M, Watanabe RM. Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q. Hum Hered. 2007; 63(1):17-25. PMID: 17179727.
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    169. Goodarzi MO, Taylor KD, Guo X, Hokanson JE, Haffner SM, Cui J, Chen YD, Wagenknecht LE, Bergman RN, Rotter JI. Haplotypes in the lipoprotein lipase gene influence fasting insulin and discovery of a new risk haplotype. J Clin Endocrinol Metab. 2007 Jan; 92(1):293-6. PMID: 17032721.
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    170. Bonnycastle LL, Willer CJ, Conneely KN, Jackson AU, Burrill CP, Watanabe RM, Chines PS, Narisu N, Scott LJ, Enloe ST, Swift AJ, Duren WL, Stringham HM, Erdos MR, Riebow NL, Buchanan TA, Valle TT, Tuomilehto J, Bergman RN, Mohlke KL, Boehnke M, Collins FS. Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns. Diabetes. 2006 Sep; 55(9):2534-40. PMID: 16936201.
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    172. Nittala A, Ghosh S, Stefanovski D, Bergman R, Wang X. Dimensional analysis of MINMOD leads to definition of the disposition index of glucose regulation and improved simulation algorithm. Biomed Eng Online. 2006 Jul 14; 5:44. PMID: 16842624.
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    173. Moss RL, Bergman RN. Association of chairs of departments of physiology 2005 survey results. Physiologist. 2006 Jun; 49(3):153, 155-6, 158-9. PMID: 16805365.
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    174. Ellmerer M, Hamilton-Wessler M, Kim SP, Huecking K, Kirkman E, Chiu J, Richey J, Bergman RN. Reduced access to insulin-sensitive tissues in dogs with obesity secondary to increased fat intake. Diabetes. 2006 Jun; 55(6):1769-75. PMID: 16731841.
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    175. Guo X, Saad MF, Langefeld CD, Williams AH, Cui J, Taylor KD, Norris JM, Jinagouda S, Darwin CH, Mitchell BD, Bergman RN, Sutton B, Chen YD, Wagenknecht LE, Bowden DW, Rotter JI. Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS family study. Diabetes. 2006 Jun; 55(6):1723-30. PMID: 16731835.
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    176. Ionut V, Liberty IF, Hucking K, Lottati M, Stefanovski D, Zheng D, Bergman RN. Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action. Am J Physiol Endocrinol Metab. 2006 Oct; 291(4):E779-85. PMID: 16720628.
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    177. Palmer ND, Langefeld CD, Campbell JK, Williams AH, Saad M, Norris JM, Haffner SM, Rotter JI, Wagenknecht LE, Bergman RN, Rich SS, Bowden DW. Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes. 2006 Apr; 55(4):911-8. PMID: 16567510.
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    178. Bergman RN, Kim SP, Catalano KJ, Hsu IR, Chiu JD, Kabir M, Hucking K, Ader M. Why visceral fat is bad: mechanisms of the metabolic syndrome. Obesity (Silver Spring). 2006 Feb; 14 Suppl 1:16S-19S. PMID: 16642958.
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    179. Willer CJ, Scott LJ, Bonnycastle LL, Jackson AU, Chines P, Pruim R, Bark CW, Tsai YY, Pugh EW, Doheny KF, Kinnunen L, Mohlke KL, Valle TT, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database. Genet Epidemiol. 2006 Feb; 30(2):180-90. PMID: 16374835.
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    180. Bergman RN. Minimal model: perspective from 2005. Horm Res. 2005; 64 Suppl 3:8-15. PMID: 16439839.
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    181. Mohlke KL, Jackson AU, Scott LJ, Peck EC, Suh YD, Chines PS, Watanabe RM, Buchanan TA, Conneely KN, Erdos MR, Narisu N, Enloe S, Valle TT, Tuomilehto J, Bergman RN, Boehnke M, Collins FS. Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns. Hum Genet. 2005 Nov; 118(2):245-54. PMID: 16142453.
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    182. Rich SS, Bergman RN. The genetic basis of glucose homeostasis. Curr Diabetes Rev. 2005 Aug; 1(3):221-6. PMID: 18220598.
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    183. Mohlke KL, Skol AD, Scott LJ, Valle TT, Bergman RN, Tuomilehto J, Boehnke M, Collins FS. Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns. Mol Genet Metab. 2005 Aug; 85(4):323-7. PMID: 15936967.
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    184. Sumner AE, Vega GL, Genovese DJ, Finley KB, Bergman RN, Boston RC. Normal triglyceride levels despite insulin resistance in African Americans: role of lipoprotein lipase. Metabolism. 2005 Jul; 54(7):902-9. PMID: 15988699.
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    185. Teran-Garcia M, Santoro N, Rankinen T, Bergeron J, Rice T, Leon AS, Rao DC, Skinner JS, Bergman RN, Després JP, Bouchard C. Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study. Diabetes. 2005 Jul; 54(7):2251-5. PMID: 15983229.
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    186. An P, Teran-Garcia M, Rice T, Rankinen T, Weisnagel SJ, Bergman RN, Boston RC, Mandel S, Stefanovski D, Leon AS, Skinner JS, Rao DC, Bouchard C. Genome-wide linkage scans for prediabetes phenotypes in response to 20 weeks of endurance exercise training in non-diabetic whites and blacks: the HERITAGE Family Study. Diabetologia. 2005 Jun; 48(6):1142-9. PMID: 15868134.
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    187. Karter AJ, D'Agostino RB, Mayer-Davis EJ, Wagenknecht LE, Hanley AJ, Hamman RF, Bergman R, Saad MF, Haffner SM. Abdominal obesity predicts declining insulin sensitivity in non-obese normoglycaemics: the Insulin Resistance Atherosclerosis Study (IRAS). Diabetes Obes Metab. 2005 May; 7(3):230-8. PMID: 15811139.
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    188. Ionut V, Hucking K, Liberty IF, Bergman RN. Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones. Diabetologia. 2005 May; 48(5):967-75. PMID: 15830188.
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    189. Bergman RN, Ader M. Atypical antipsychotics and glucose homeostasis. J Clin Psychiatry. 2005 Apr; 66(4):504-14. PMID: 15816794.
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    190. Boston RC, Moate PJ, Stefanovski D, Sumner AE, Bergman RN. AKA-Glucose: a program for kinetic and epidemiological analysis of frequently sampled intravenous glucose tolerance test data using database technology. Diabetes Technol Ther. 2005 Apr; 7(2):298-307. PMID: 15857232.
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    191. Ader M, Kim SP, Catalano KJ, Ionut V, Hucking K, Richey JM, Kabir M, Bergman RN. Metabolic dysregulation with atypical antipsychotics occurs in the absence of underlying disease: a placebo-controlled study of olanzapine and risperidone in dogs. Diabetes. 2005 Mar; 54(3):862-71. PMID: 15734866.
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    192. Boulé NG, Weisnagel SJ, Lakka TA, Tremblay A, Bergman RN, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care. 2005 Jan; 28(1):108-14. PMID: 15616242.
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    193. Norris JM, Langefeld CD, Scherzinger AL, Rich SS, Bookman E, Beck SR, Saad MF, Haffner SM, Bergman RN, Bowden DW, Wagenknecht LE. Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: the IRAS Family study. Int J Obes (Lond). 2005 Jan; 29(1):67-77. PMID: 15534617.
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    194. Ukkola O, Santaniemi M, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bergman R, Kesäniemi YA, Bouchard C. Adiponectin polymorphisms, adiposity and insulin metabolism: HERITAGE family study and Oulu diabetic study. Ann Med. 2005; 37(2):141-50. PMID: 16028335.
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    195. Catalano KJ, Bergman RN, Ader M. Increased susceptibility to insulin resistance associated with abdominal obesity in aging rats. Obes Res. 2005 Jan; 13(1):11-20. PMID: 15761159.
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    196. Rich SS, Bowden DW, Haffner SM, Norris JM, Saad MF, Mitchell BD, Rotter JI, Langefeld CD, Hedrick CC, Wagenknecht LE, Bergman RN. A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study. Diabetes. 2005 Jan; 54(1):290-5. PMID: 15616041.
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    197. Kabir M, Catalano KJ, Ananthnarayan S, Kim SP, Van Citters GW, Dea MK, Bergman RN. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Am J Physiol Endocrinol Metab. 2005 Feb; 288(2):E454-61. PMID: 15522994.
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    198. Palmer ND, Bento JL, Mychaleckyj JC, Langefeld CD, Campbell JK, Norris JM, Haffner SM, Bergman RN, Bowden DW. Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study. Diabetes. 2004 Nov; 53(11):3013-9. PMID: 15504985.
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    199. Ellmerer M, Kim SP, Hamilton-Wessler M, Hücking K, Kirkman E, Bergman RN. Physiological hyperinsulinemia in dogs augments access of macromolecules to insulin-sensitive tissues. Diabetes. 2004 Nov; 53(11):2741-7. PMID: 15504953.
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    200. Conneely KN, Silander K, Scott LJ, Mohlke KL, Lazaridis KN, Valle TT, Tuomilehto J, Bergman RN, Watanabe RM, Buchanan TA, Collins FS, Boehnke M. Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects. Diabetologia. 2004 Oct; 47(10):1782-8. PMID: 15517149.
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    201. Sumner AE, Bergman RN, Vega GL, Genovese DJ, Cochran CS, Pacak K, Watanabe RM, Boston RC. The multiphasic profile of free fatty acids during the intravenous glucose tolerance test is unresponsive to exogenous insulin. Metabolism. 2004 Sep; 53(9):1202-7. PMID: 15334385.
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    202. Ionut V, Kirkman EL, Bergman RN. Investigation of the effect of acepromazine on intravenous glucose tolerance tests in dogs. Am J Vet Res. 2004 Aug; 65(8):1124-7. PMID: 15334847.
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    204. Lakka TA, Rankinen T, Weisnagel SJ, Chagnon YC, Lakka HM, Ukkola O, Boulé N, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bergman R, Bouchard C. Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study. Diabetes. 2004 Jun; 53(6):1603-8. PMID: 15161768.
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    205. Saad MF, Rewers M, Selby J, Howard G, Jinagouda S, Fahmi S, Zaccaro D, Bergman RN, Savage PJ, Haffner SM. Insulin resistance and hypertension: the Insulin Resistance Atherosclerosis study. Hypertension. 2004 Jun; 43(6):1324-31. PMID: 15123571.
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    206. Mitchell BD, Zaccaro D, Wagenknecht LE, Scherzinger AL, Bergman RN, Haffner SM, Hokanson J, Norris JM, Rotter JI, Saad MF. Insulin sensitivity, body fat distribution, and family diabetes history: the IRAS Family Study. Obes Res. 2004 May; 12(5):831-9. PMID: 15166304.
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    207. Silander K, Mohlke KL, Scott LJ, Peck EC, Hollstein P, Skol AD, Jackson AU, Deloukas P, Hunt S, Stavrides G, Chines PS, Erdos MR, Narisu N, Conneely KN, Li C, Fingerlin TE, Dhanjal SK, Valle TT, Bergman RN, Tuomilehto J, Watanabe RM, Boehnke M, Collins FS. Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes. 2004 Apr; 53(4):1141-9. PMID: 15047633.
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    208. Rewers M, Zaccaro D, D'Agostino R, Haffner S, Saad MF, Selby JV, Bergman R, Savage P. Insulin sensitivity, insulinemia, and coronary artery disease: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 2004 Mar; 27(3):781-7. PMID: 14988302.
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    209. Silander K, Scott LJ, Valle TT, Mohlke KL, Stringham HM, Wiles KR, Duren WL, Doheny KF, Pugh EW, Chines P, Narisu N, White PP, Fingerlin TE, Jackson AU, Li C, Ghosh S, Magnuson VL, Colby K, Erdos MR, Hill JE, Hollstein P, Humphreys KM, Kasad RA, Lambert J, Lazaridis KN, Lin G, Morales-Mena A, Patzkowski K, Pfahl C, Porter R, Rha D, Segal L, Suh YD, Tovar J, Unni A, Welch C, Douglas JA, Epstein MP, Hauser ER, Hagopian W, Buchanan TA, Watanabe RM, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. Diabetes. 2004 Mar; 53(3):821-9. PMID: 14988269.
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    210. Goran MI, Bergman RN, Avila Q, Watkins M, Ball GD, Shaibi GQ, Weigensberg MJ, Cruz ML. Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes. J Clin Endocrinol Metab. 2004 Jan; 89(1):207-12. PMID: 14715851.
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    211. Cohen DM, Bergman RN. Estimation of metabolic flux from dominant rate constants in vivo: application to brain and heart. Metab Eng. 2004 Jan; 6(1):59-74. PMID: 14734256.
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    212. Guttman-Yassky E, Bar-Chana M, Yukelson A, Linn S, Friedman-Birnbaum R, Bergman R, Sarid R, Silbermann M. Epidemiology of classic Kaposi's sarcoma in the Israeli Jewish population between 1960 and 1998. Br J Cancer. 2003 Nov 03; 89(9):1657-60. PMID: 14583765.
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    213. Haffner SM, D'Agostino R, Festa A, Bergman RN, Mykkänen L, Karter A, Saad MF, Wagenknecht LE. Low insulin sensitivity (S(i) = 0) in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study: is it associated with components of the metabolic syndrome and nontraditional risk factors? Diabetes Care. 2003 Oct; 26(10):2796-803. PMID: 14514582.
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    214. Bergman RN. Insulin action and distribution of tissue blood flow. J Clin Endocrinol Metab. 2003 Oct; 88(10):4556-8. PMID: 14557421.
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    221. Boston RC, Stefanovski D, Moate PJ, Sumner AE, Watanabe RM, Bergman RN. MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test. Diabetes Technol Ther. 2003; 5(6):1003-15. PMID: 14709204.
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    222. Hücking K, Hamilton-Wessler M, Ellmerer M, Bergman RN. Burst-like control of lipolysis by the sympathetic nervous system in vivo. J Clin Invest. 2003 Jan; 111(2):257-64. PMID: 12531882.
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    227. Bergman RN. Pathogenesis and prediction of diabetes mellitus: lessons from integrative physiology. Mt Sinai J Med. 2002 Oct; 69(5):280-90. PMID: 12415321.
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    229. Bergman RN, Finegood DT, Kahn SE. The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes. Eur J Clin Invest. 2002 Jun; 32 Suppl 3:35-45. PMID: 12028373.
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    230. Fingerlin TE, Erdos MR, Watanabe RM, Wiles KR, Stringham HM, Mohlke KL, Silander K, Valle TT, Buchanan TA, Tuomilehto J, Bergman RN, Boehnke M, Collins FS. Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort. Diabetes. 2002 May; 51(5):1644-8. PMID: 11978669.
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    231. Hanley AJ, D'Agostino R, Wagenknecht LE, Saad MF, Savage PJ, Bergman R, Haffner SM. Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study. Diabetes. 2002 Apr; 51(4):1263-70. PMID: 11916954.
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    232. Hamilton-Wessler M, Ader M, Dea MK, Moore D, Loftager M, Markussen J, Bergman RN. Mode of transcapillary transport of insulin and insulin analog NN304 in dog hindlimb: evidence for passive diffusion. Diabetes. 2002 Mar; 51(3):574-82. PMID: 11872653.
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    233. Dea MK, Hamilton-Wessler M, Ader M, Moore D, Schäffer L, Loftager M, Vølund A, Bergman RN. Albumin binding of acylated insulin (NN304) does not deter action to stimulate glucose uptake. Diabetes. 2002 Mar; 51(3):762-9. PMID: 11872677.
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    234. Mittelman SD, Van Citters GW, Kirkman EL, Bergman RN. Extreme insulin resistance of the central adipose depot in vivo. Diabetes. 2002 Mar; 51(3):755-61. PMID: 11872676.
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    235. Bergman RN, Ader M, Huecking K, Van Citters G. Accurate assessment of beta-cell function: the hyperbolic correction. Diabetes. 2002 Feb; 51 Suppl 1:S212-20. PMID: 11815482.
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    236. Resnick HE, Bergman RN, Henderson JA, Nez-Henderson P, Howard BV. Utility of a surrogate measure of insulin resistance in American Indians: the Strong Heart Study. Ethn Dis. 2002; 12(4):523-9. PMID: 12477138.
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    237. Gresl TA, Colman RJ, Roecker EB, Havighurst TC, Huang Z, Allison DB, Bergman RN, Kemnitz JW. Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr. Am J Physiol Endocrinol Metab. 2001 Oct; 281(4):E757-65. PMID: 11551852.
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    238. Sprecher E, Bergman R, Richard G, Lurie R, Shalev S, Petronius D, Shalata A, Anbinder Y, Leibu R, Perlman I, Cohen N, Szargel R. Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin. Nat Genet. 2001 Oct; 29(2):134-6. PMID: 11544476.
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    239. Fosgerau K, Mittelman SD, Sunehag A, Dea MK, Lundgren K, Bergman RN. Lack of hepatic "interregulation" during inhibition of glycogenolysis in a canine model. Am J Physiol Endocrinol Metab. 2001 Aug; 281(2):E375-83. PMID: 11440915.
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    240. Goran MI, Bergman RN, Gower BA. Influence of total vs. visceral fat on insulin action and secretion in African American and white children. Obes Res. 2001 Aug; 9(8):423-31. PMID: 11500522.
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    241. Mohlke KL, Lange EM, Valle TT, Ghosh S, Magnuson VL, Silander K, Watanabe RM, Chines PS, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. Linkage disequilibrium between microsatellite markers extends beyond 1 cM on chromosome 20 in Finns. Genome Res. 2001 Jul; 11(7):1221-6. PMID: 11435404.
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    242. Hong Y, Weisnagel SJ, Rice T, Sun G, Mandel SA, Gu C, Rankinen T, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Bergman RN, Bouchard C, Rao DC. Familial resemblance for glucose and insulin metabolism indices derived from an intravenous glucose tolerance test in Blacks and Whites of the HERITAGE Family Study. Clin Genet. 2001 Jul; 60(1):22-30. PMID: 11531966.
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    243. Douglas JA, Erdos MR, Watanabe RM, Braun A, Johnston CL, Oeth P, Mohlke KL, Valle TT, Ehnholm C, Buchanan TA, Bergman RN, Collins FS, Boehnke M, Tuomilehto J. The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences. Diabetes. 2001 Apr; 50(4):886-90. PMID: 11289057.
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    244. Mayer-Davis EJ, Levin S, Bergman RN, D'Agostino RB, Karter AJ, Saad MF. Insulin secretion, obesity, and potential behavioral influences: results from the Insulin Resistance Atherosclerosis Study (IRAS). Diabetes Metab Res Rev. 2001 Mar-Apr; 17(2):137-45. PMID: 11307179.
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    245. Raz A, Bergman R, Eilam O, Yungerman T, Hayek T. A case report of olanzapine-induced hypersensitivity syndrome. Am J Med Sci. 2001 Feb; 321(2):156-8. PMID: 11217818.
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    246. Hevener AL, Bergman RN, Donovan CM. Hypoglycemic detection does not occur in the hepatic artery or liver: findings consistent with a portal vein glucosensor locus. Diabetes. 2001 Feb; 50(2):399-403. PMID: 11272153.
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    247. Bergman RN, Van Citters GW, Mittelman SD, Dea MK, Hamilton-Wessler M, Kim SP, Ellmerer M. Central role of the adipocyte in the metabolic syndrome. J Investig Med. 2001 Jan; 49(1):119-26. PMID: 11217141.
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    248. Mittelman SD, Van Citters GW, Kim SP, Davis DA, Dea MK, Hamilton-Wessler M, Bergman RN. Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response. Diabetes. 2000 Dec; 49(12):2116-25. PMID: 11118015.
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    249. Dea MK, Van Citters GW, Ader M, Mittelman SD, Sunehag AL, Bergman RN. Paradoxical effect of troglitazone in normal animals: enhancement of adipocyte but reduction of liver insulin sensitivity. Diabetes. 2000 Dec; 49(12):2087-93. PMID: 11118011.
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    250. Bergman RN, Ader M. Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab. 2000 Nov; 11(9):351-6. PMID: 11042464.
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    251. Caumo A, Bergman RN, Cobelli C. Insulin sensitivity from meal tolerance tests in normal subjects: a minimal model index. J Clin Endocrinol Metab. 2000 Nov; 85(11):4396-402. PMID: 11095485.
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    252. Mittelman SD, Bergman RN. Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin. Am J Physiol Endocrinol Metab. 2000 Sep; 279(3):E630-7. PMID: 10950832.
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    253. Getty L, Panteleon AE, Mittelman SD, Dea MK, Bergman RN. Rapid oscillations in omental lipolysis are independent of changing insulin levels in vivo. J Clin Invest. 2000 Aug; 106(3):421-30. PMID: 10930445.
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    254. Bergman RN. Non-esterified fatty acids and the liver: why is insulin secreted into the portal vein? Diabetologia. 2000 Jul; 43(7):946-52. PMID: 10952470.
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    255. Haffner SM, Agostino RD, Saad MF, O'Leary DH, Savage PJ, Rewers M, Selby J, Bergman RN, Mykkänen L. Carotid artery atherosclerosis in type-2 diabetic and nondiabetic subjects with and without symptomatic coronary artery disease (The Insulin Resistance Atherosclerosis Study). Am J Cardiol. 2000 Jun 15; 85(12):1395-400. PMID: 10856382.
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    256. Kjems LL, Christiansen E, Vølund A, Bergman RN, Madsbad S. Validation of methods for measurement of insulin secretion in humans in vivo. Diabetes. 2000 Apr; 49(4):580-8. PMID: 10871195.
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    257. Woods KA, Camacho-Hübner C, Bergman RN, Barter D, Clark AJ, Savage MO. Effects of insulin-like growth factor I (IGF-I) therapy on body composition and insulin resistance in IGF-I gene deletion. J Clin Endocrinol Metab. 2000 Apr; 85(4):1407-11. PMID: 10770174.
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    258. Watanabe RM, Bergman RN. Accurate measurement of endogenous insulin secretion does not require separate assessment of C-peptide kinetics. Diabetes. 2000 Mar; 49(3):373-82. PMID: 10868958.
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    259. Carpentier A, Mittelman SD, Bergman RN, Giacca A, Lewis GF. Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes. Diabetes. 2000 Mar; 49(3):399-408. PMID: 10868961.
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    260. Hevener AL, Bergman RN, Donovan CM. Portal vein afferents are critical for the sympathoadrenal response to hypoglycemia. Diabetes. 2000 Jan; 49(1):8-12. PMID: 10615943.
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    261. Richey JM, Ader M, Moore D, Bergman RN. Angiotensin II induces insulin resistance independent of changes in interstitial insulin. Am J Physiol. 1999 11; 277(5):E920-6. PMID: 10567021.
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    262. Hamilton-Wessler M, Ader M, Dea M, Moore D, Jorgensen PN, Markussen J, Bergman RN. Mechanism of protracted metabolic effects of fatty acid acylated insulin, NN304, in dogs: retention of NN304 by albumin. Diabetologia. 1999 Oct; 42(10):1254-63. PMID: 10525669.
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    263. Sprecher E, Lestringant GG, Szargel R, Bergman R, Labay V, Frossard PM, Friedman-Birnbaum R, Cohen N. Atrichia with papular lesions resulting from a nonsense mutation within the human hairless gene. J Invest Dermatol. 1999 Oct; 113(4):687-90. PMID: 10504459.
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    265. Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A, Lewis GF. Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am J Physiol. 1999 06; 276(6):E1055-66. PMID: 10362618.
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    266. Watanabe RM, Valle T, Hauser ER, Ghosh S, Eriksson J, Kohtamäki K, Ehnholm C, Tuomilehto J, Collins FS, Bergman RN, Boehnke M. Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators. Hum Hered. 1999 Jun; 49(3):159-68. PMID: 10364681.
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    267. Richey JM, Poulin RA, Buchanan TA, Galperin E, Moore DM, Bergman RN. Failure of acute hyperinsulinemia to alter blood pressure is not due to baroreceptor feedback. Am J Hypertens. 1999 Apr; 12(4 Pt 1):405-13. PMID: 10232501.
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    268. Ghosh S, Watanabe RM, Hauser ER, Valle T, Magnuson VL, Erdos MR, Langefeld CD, Balow J, Ally DS, Kohtamaki K, Chines P, Birznieks G, Kaleta HS, Musick A, Te C, Tannenbaum J, Eldridge W, Shapiro S, Martin C, Witt A, So A, Chang J, Shurtleff B, Porter R, Kudelko K, Unni A, Segal L, Sharaf R, Blaschak-Harvan J, Eriksson J, Tenkula T, Vidgren G, Ehnholm C, Tuomilehto-Wolf E, Hagopian W, Buchanan TA, Tuomilehto J, Bergman RN, Collins FS, Boehnke M. Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2198-203. PMID: 10051618.
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    269. Ghosh S, Langefeld CD, Ally D, Watanabe RM, Hauser ER, Magnuson VL, Nylund SJ, Valle T, Eriksson J, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample. Diabetologia. 1999 Feb; 42(2):238-44. PMID: 10064105.
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    270. Sprecher E, Bergman R, Szargel R, Raz T, Labay V, Ramon M, Baruch-Gershoni R, Friedman-Birnbaum R, Cohen N. Atrichia with papular lesions maps to 8p in the region containing the human hairless gene. Am J Med Genet. 1998 Dec 28; 80(5):546-50. PMID: 9880231.
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    271. Getty L, Hamilton-Wessler M, Ader M, Dea MK, Bergman RN. Biphasic insulin secretion during intravenous glucose tolerance test promotes optimal interstitial insulin profile. Diabetes. 1998 Dec; 47(12):1941-7. PMID: 9836528.
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    272. Ader M, Richey JM, Bergman RN. Evidence for direct action of alloxan to induce insulin resistance at the cellular level. Diabetologia. 1998 Nov; 41(11):1327-36. PMID: 9833941.
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    273. Haffner SM, D'Agostino R, Mykkänen L, Hales CN, Savage PJ, Bergman RN, O'Leary D, Rewers M, Selby J, Tracy R, Saad MF. Proinsulin and insulin concentrations in relation to carotid wall thickness: Insulin Resistance Atherosclerosis Study. Stroke. 1998 Aug; 29(8):1498-503. PMID: 9707183.
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    274. Howard G, Bergman R, Wagenknecht LE, Haffner SM, Savage PJ, Saad MF, Laws A, D'Agostino RB. Ability of alternative indices of insulin sensitivity to predict cardiovascular risk: comparison with the "minimal model". Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Ann Epidemiol. 1998 Aug; 8(6):358-69. PMID: 9708871.
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    275. Valle T, Tuomilehto J, Bergman RN, Ghosh S, Hauser ER, Eriksson J, Nylund SJ, Kohtamäki K, Toivanen L, Vidgren G, Tuomilehto-Wolf E, Ehnholm C, Blaschak J, Langefeld CD, Watanabe RM, Magnuson V, Ally DS, Hagopian WA, Ross E, Buchanan TA, Collins F, Boehnke M. Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care. 1998 Jun; 21(6):949-58. PMID: 9614613.
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    276. Steil GM, Rebrin K, Mittelman SD, Bergman RN. Role of portal insulin delivery in the disappearance of intravenous glucose and assessment of insulin sensitivity. Diabetes. 1998 May; 47(5):714-20. PMID: 9588441.
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    277. Mayer-Davis EJ, D'Agostino R, Karter AJ, Haffner SM, Rewers MJ, Saad M, Bergman RN. Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study. JAMA. 1998 Mar 04; 279(9):669-74. PMID: 9496984.
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    278. Shemer A, Bergman R, Linn S, Kantor Y, Friedman-Birnbaum R. Diabetic dermopathy and internal complications in diabetes mellitus. Int J Dermatol. 1998 Feb; 37(2):113-5. PMID: 9542665.
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    279. Watanabe RM, Steil GM, Bergman RN. Critical evaluation of the combined model approach for estimation of prehepatic insulin secretion. Am J Physiol. 1998 01; 274(1):E172-83. PMID: 9458763.
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    280. Bergman RN, Mittelman SD. Central role of the adipocyte in insulin resistance. J Basic Clin Physiol Pharmacol. 1998; 9(2-4):205-21. PMID: 10212835.
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    281. Mittelman SD, Fu YY, Rebrin K, Steil G, Bergman RN. Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia. J Clin Invest. 1997 Dec 15; 100(12):3121-30. PMID: 9399959.
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    282. Saad MF, Steil GM, Riad-Gabriel M, Khan A, Sharma A, Boyadjian R, Jinagouda SD, Bergman RN. Method of insulin administration has no effect on insulin sensitivity estimates from the insulin-modified minimal model protocol. Diabetes. 1997 Dec; 46(12):2044-8. PMID: 9392494.
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    283. Cohen DM, Bergman RN. Improved estimation of anaplerosis in heart using 13C NMR. Am J Physiol. 1997 12; 273(6):E1228-42. PMID: 9435540.
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    284. Ni TC, Ader M, Bergman RN. Reassessment of glucose effectiveness and insulin sensitivity from minimal model analysis: a theoretical evaluation of the single-compartment glucose distribution assumption. Diabetes. 1997 Nov; 46(11):1813-21. PMID: 9356031.
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    285. Hevener AL, Bergman RN, Donovan CM. Novel glucosensor for hypoglycemic detection localized to the portal vein. Diabetes. 1997 Sep; 46(9):1521-5. PMID: 9287058.
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    286. Mykkänen L, Haffner SM, Rönnemaa T, Bergman RN, Laakso M. Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors. Am J Epidemiol. 1997 Aug 15; 146(4):315-21. PMID: 9270410.
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    287. Saad MF, Steil GM, Kades WW, Ayad MF, Elsewafy WA, Boyadjian R, Jinagouda SD, Bergman RN. Differences between the tolbutamide-boosted and the insulin-modified minimal model protocols. Diabetes. 1997 Jul; 46(7):1167-71. PMID: 9200652.
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    288. Ader M, Ni TC, Bergman RN. Glucose effectiveness assessed under dynamic and steady state conditions. Comparability of uptake versus production components. J Clin Invest. 1997 Mar 15; 99(6):1187-99. PMID: 9077526.
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    289. Hofman PL, Cutfield WS, Robinson EM, Bergman RN, Menon RK, Sperling MA, Gluckman PD. Insulin resistance in short children with intrauterine growth retardation. J Clin Endocrinol Metab. 1997 Feb; 82(2):402-6. PMID: 9024226.
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    290. Bergman RN. New concepts in extracellular signaling for insulin action: the single gateway hypothesis. Recent Prog Horm Res. 1997; 52:359-85; discussion 385-7. PMID: 9238859.
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    291. Mayer-Davis EJ, Monaco JH, Hoen HM, Carmichael S, Vitolins MZ, Rewers MJ, Haffner SM, Ayad MF, Bergman RN, Karter AJ. Dietary fat and insulin sensitivity in a triethnic population: the role of obesity. The Insulin Resistance Atherosclerosis Study (IRAS) Am J Clin Nutr. 1997 Jan; 65(1):79-87. PMID: 8988917.
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    292. Haffner SM, Howard G, Mayer E, Bergman RN, Savage PJ, Rewers M, Mykkänen L, Karter AJ, Hamman R, Saad MF. Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. Diabetes. 1997 Jan; 46(1):63-9. PMID: 8971083.
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    293. Steil GM, Richey J, Kim JK, Wi JK, Rebrin K, Bergman RN, Youn JH. Extracellular glucose distribution is not altered by insulin: analysis of plasma and interstitial L-glucose kinetics. Am J Physiol. 1996 Nov; 271(5 Pt 1):E855-64. PMID: 8944672.
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    294. Karter AJ, Mayer-Davis EJ, Selby JV, D'Agostino RB, Haffner SM, Sholinsky P, Bergman R, Saad MF, Hamman RF. Insulin sensitivity and abdominal obesity in African-American, Hispanic, and non-Hispanic white men and women. The Insulin Resistance and Atherosclerosis Study. Diabetes. 1996 Nov; 45(11):1547-55. PMID: 8866560.
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    295. D'Agostino RB, Burke G, O'Leary D, Rewers M, Selby J, Savage PJ, Saad MF, Bergman RN, Howard G, Wagenknecht L, Haffner SM. Ethnic differences in carotid wall thickness. The Insulin Resistance Atherosclerosis Study. Stroke. 1996 Oct; 27(10):1744-9. PMID: 8841322.
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    296. Best JD, Kahn SE, Ader M, Watanabe RM, Ni TC, Bergman RN. Role of glucose effectiveness in the determination of glucose tolerance. Diabetes Care. 1996 Sep; 19(9):1018-30. PMID: 8875104.
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    297. Bergman RN, Watanabe R, Rebrin K, Ader M, Steil G. Toward an integrated phenotype in pre-NIDDM. Diabet Med. 1996 Sep; 13(9 Suppl 6):S67-77. PMID: 8894486.
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    298. Clausen JO, Borch-Johnsen K, Ibsen H, Bergman RN, Hougaard P, Winther K, Pedersen O. Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. J Clin Invest. 1996 Sep 01; 98(5):1195-209. PMID: 8787683.
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    299. Rebrin K, Steil GM, Mittelman SD, Bergman RN. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest. 1996 Aug 01; 98(3):741-9. PMID: 8698866.
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    300. Howard G, O'Leary DH, Zaccaro D, Haffner S, Rewers M, Hamman R, Selby JV, Saad MF, Savage P, Bergman R. Insulin sensitivity and atherosclerosis. The Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Circulation. 1996 May 15; 93(10):1809-17. PMID: 8635260.
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    301. Steil GM, Ader M, Moore DM, Rebrin K, Bergman RN. Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process. J Clin Invest. 1996 Mar 15; 97(6):1497-503. PMID: 8617883.
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    302. Hamilton-Wessler M, Donovan CM, Bergman RN. [Role of the liver as a glucose sensor in the integrated response to hypoglycemia]. Journ Annu Diabetol Hotel Dieu. 1996; 19-35. PMID: 8965421.
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    303. Rebrin K, Steil GM, Getty L, Bergman RN. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes. 1995 Sep; 44(9):1038-45. PMID: 7657026.
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    304. Watanabe RM, Lovejoy J, Steil GM, DiGirolamo M, Bergman RN. Insulin sensitivity accounts for glucose and lactate kinetics after intravenous glucose injection. Diabetes. 1995 Aug; 44(8):954-62. PMID: 7622002.
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    305. Cohen DM, Bergman RN. Estimation of TCA cycle flux, aminotransferase flux, and anaplerosis in heart: validation with syntactic model. Am J Physiol. 1995 Mar; 268(3 Pt 1):E397-409. PMID: 7900786.
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    306. Bradley DC, Steil GM, Bergman RN. OOPSEG: a data smoothing program for quantitation and isolation of random measurement error. Comput Methods Programs Biomed. 1995 Jan; 46(1):67-77. PMID: 7743783.
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    307. Watanabe RM, Azen CG, Roy S, Perlman JA, Bergman RN. Defects in carbohydrate metabolism in oral contraceptive users without apparent metabolic risk factors. J Clin Endocrinol Metab. 1994 Nov; 79(5):1277-83. PMID: 7962320.
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    308. Steil GM, Murray J, Bergman RN, Buchanan TA. Repeatability of insulin sensitivity and glucose effectiveness from the minimal model. Implications for study design. Diabetes. 1994 Nov; 43(11):1365-71. PMID: 7926313.
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    309. Saad MF, Anderson RL, Laws A, Watanabe RM, Kades WW, Chen YD, Sands RE, Pei D, Savage PJ, Bergman RN. A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Insulin Resistance Atherosclerosis Study. Diabetes. 1994 Sep; 43(9):1114-21. PMID: 8070611.
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    310. Hamilton-Wessler M, Bergman RN, Halter JB, Watanabe RM, Donovan CM. The role of liver glucosensors in the integrated sympathetic response induced by deep hypoglycemia in dogs. Diabetes. 1994 Aug; 43(8):1052-60. PMID: 8039600.
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    311. Mykkänen L, Rönnemaa T, Marniemi J, Haffner SM, Bergman R, Laakso M. Insulin sensitivity is not an independent determinant of plasma plasminogen activator inhibitor-1 activity. Arterioscler Thromb. 1994 Aug; 14(8):1264-71. PMID: 8049187.
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    312. Mykkänen L, Haffner SM, Rönnemaa T, Bergman R, Leino A, Laakso M. Is there a sex difference in the association of plasma insulin level and insulin sensitivity with serum lipids and lipoproteins? Metabolism. 1994 Apr; 43(4):523-8. PMID: 8159115.
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    313. Cohen DM, Bergman RN. SYNTAX: a rule-based stochastic simulation of the time-varying concentrations of positional isotopomers of metabolic intermediates. Comput Biomed Res. 1994 Apr; 27(2):130-47. PMID: 8033538.
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    314. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP. The contribution of insulin-dependent and insulin-independent glucose uptake to intravenous glucose tolerance in healthy human subjects. Diabetes. 1994 Apr; 43(4):587-92. PMID: 8138065.
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    315. Kemnitz JW, Roecker EB, Weindruch R, Elson DF, Baum ST, Bergman RN. Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol. 1994 Apr; 266(4 Pt 1):E540-7. PMID: 8178974.
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    316. Donovan CM, Hamilton-Wessler M, Halter JB, Bergman RN. Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2863-7. PMID: 8146201.
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    317. Cohen DM, Bergman RN. Prediction of positional isotopomers of the citric acid cycle: the syntactic approach. Am J Physiol. 1994 Mar; 266(3 Pt 1):E341-50. PMID: 7909408.
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    318. Kemnitz JW, Elson DF, Roecker EB, Baum ST, Bergman RN, Meglasson MD. Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure, in obese, insulin-resistant rhesus monkeys. Diabetes. 1994 Feb; 43(2):204-11. PMID: 8288044.
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    319. Bergman R. The pathogenesis and clinical significance of xanthelasma palpebrarum. J Am Acad Dermatol. 1994 Feb; 30(2 Pt 1):236-42. PMID: 8288783.
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    320. Poulin RA, Steil GM, Moore DM, Ader M, Bergman RN. Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph. Diabetes. 1994 Feb; 43(2):180-90. PMID: 8288041.
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    321. Yang YJ, Hope ID, Ader M, Bergman RN. Importance of transcapillary insulin transport to dynamics of insulin action after intravenous glucose. Am J Physiol. 1994 Jan; 266(1 Pt 1):E17-25. PMID: 8304440.
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    322. Castillo C, Bogardus C, Bergman R, Thuillez P, Lillioja S. Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men. J Clin Invest. 1994 Jan; 93(1):10-6. PMID: 8282776.
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    323. Wing RR, Blair EH, Bononi P, Marcus MD, Watanabe R, Bergman RN. Caloric restriction per se is a significant factor in improvements in glycemic control and insulin sensitivity during weight loss in obese NIDDM patients. Diabetes Care. 1994 Jan; 17(1):30-6. PMID: 8112186.
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    324. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes. 1993 Nov; 42(11):1663-72. PMID: 8405710.
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    325. Buyalos RP, Geffner ME, Watanabe RM, Bergman RN, Gornbein JA, Judd HL. The influence of luteinizing hormone and insulin on sex steroids and sex hormone-binding globulin in the polycystic ovarian syndrome. Fertil Steril. 1993 Oct; 60(4):626-33. PMID: 8405515.
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    326. Baura GD, Foster DM, Porte D, Kahn SE, Bergman RN, Cobelli C, Schwartz MW. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J Clin Invest. 1993 Oct; 92(4):1824-30. PMID: 8408635.
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    327. Bradley DC, Steil GM, Bergman RN. Quantitation of measurement error with Optimal Segments: basis for adaptive time course smoothing. Am J Physiol. 1993 Jun; 264(6 Pt 1):E902-11. PMID: 8333516.
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    328. Nadler JL, Buchanan T, Natarajan R, Antonipillai I, Bergman R, Rude R. Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension. 1993 Jun; 21(6 Pt 2):1024-9. PMID: 8505087.
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    329. Steil GM, Meador MA, Bergman RN. Thoracic duct lymph. Relative contribution from splanchnic and muscle tissue. Diabetes. 1993 May; 42(5):720-31. PMID: 8482429.
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    330. Kruszynska YT, Harry DS, Bergman RN, McIntyre N. Insulin sensitivity, insulin secretion and glucose effectiveness in diabetic and non-diabetic cirrhotic patients. Diabetologia. 1993 Feb; 36(2):121-8. PMID: 8458526.
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    331. Bradley DC, Poulin RA, Bergman RN. Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo. Diabetes. 1993 Feb; 42(2):296-306. PMID: 8093879.
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    332. Steil GM, Volund A, Kahn SE, Bergman RN. Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Suitability for use in population studies. Diabetes. 1993 Feb; 42(2):250-6. PMID: 8425661.
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    333. Morrow LA, Morganroth GS, Herman WH, Bergman RN, Halter JB. Effects of epinephrine on insulin secretion and action in humans. Interaction with aging. Diabetes. 1993 Feb; 42(2):307-15. PMID: 8425666.
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    334. de Meer K, Bergman R, Kusner JS. Socio-cultural determinants of child mortality in southern Peru: including some methodological considerations. Soc Sci Med. 1993 Feb; 36(3):317-31. PMID: 8426976.
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    335. Bergman RN, Bradley DC, Ader M. On insulin action in vivo: the single gateway hypothesis. Adv Exp Med Biol. 1993; 334:181-98. PMID: 8249682.
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    336. de Meer K, Bergman R, Kusner JS, Voorhoeve HW. Differences in physical growth of Aymara and Quechua children living at high altitude in Peru. Am J Phys Anthropol. 1993 Jan; 90(1):59-75. PMID: 8470756.
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    337. Supiano MA, Hogikyan RV, Morrow LA, Ortiz-Alonso FJ, Herman WH, Bergman RN, Halter JB. Hypertension and insulin resistance: role of sympathetic nervous system activity. Am J Physiol. 1992 Nov; 263(5 Pt 1):E935-42. PMID: 1443127.
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    338. Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet. 1992 Oct 17; 340(8825):925-9. PMID: 1357346.
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    339. Lee A, Ader M, Bray GA, Bergman RN. Diurnal variation in glucose tolerance. Cyclic suppression of insulin action and insulin secretion in normal-weight, but not obese, subjects. Diabetes. 1992 Jun; 41(6):750-9. PMID: 1587401.
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    340. Kahn SE, Bergman RN, Schwartz MW, Taborsky GJ, Porte D. Short-term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose action in normal humans. Am J Physiol. 1992 Apr; 262(4 Pt 1):E518-23. PMID: 1566838.
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    341. Bradley DC, Bergman RN. Restoration of stable metabolic conditions during islet suppression in dogs. Am J Physiol. 1992 Apr; 262(4 Pt 1):E532-8. PMID: 1348903.
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    342. Bradley DC, Bergman RN. Hepatic glucagon sensitivity and fasting glucose concentration in normal dogs. Am J Physiol. 1992 Apr; 262(4 Pt 1):E539-45. PMID: 1566839.
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    343. Buyalos RP, Geffner ME, Bersch N, Judd HL, Watanabe RM, Bergman RN, Golde DW. Insulin and insulin-like growth factor-I responsiveness in polycystic ovarian syndrome. Fertil Steril. 1992 Apr; 57(4):796-803. PMID: 1555690.
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    344. Pacini G, Ader M, Bergman RN. BASREP: a method for maintaining euglycemia during somatostatin suppression of pancreatic secretion. Comput Methods Programs Biomed. 1992 Mar; 37(2):107-15. PMID: 1353714.
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    345. Haffner SM, Stern MP, Watanabe RM, Bergman RN. Relationship of insulin clearance and secretion to insulin sensitivity in non-diabetic Mexican Americans. Eur J Clin Invest. 1992 Mar; 22(3):147-53. PMID: 1582438.
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    346. Yang YJ, Hope I, Ader M, Poulin RA, Bergman RN. Dose-response relationship between lymph insulin and glucose uptake reveals enhanced insulin sensitivity of peripheral tissues. Diabetes. 1992 Feb; 41(2):241-53. PMID: 1733816.
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    347. Bergman RN, Steil GM, Bradley DC, Watanabe RM. Modeling of insulin action in vivo. Annu Rev Physiol. 1992; 54:861-83. PMID: 1562195.
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    348. Watanabe RM, Vølund A, Bergman RN. Intravenous insulin infusion to simulate subcutaneous absorption. Bioavailability and metabolic sequelae. Diabetes Care. 1991 Nov; 14(11):1021-30. PMID: 1797482.
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    349. Schwartz MW, Bergman RN, Kahn SE, Taborsky GJ, Fisher LD, Sipols AJ, Woods SC, Steil GM, Porte D. Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport. J Clin Invest. 1991 Oct; 88(4):1272-81. PMID: 1918377.
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    350. Buchanan TA, Sipos GF, Gadalah S, Yip KP, Marsh DJ, Hsueh W, Bergman RN. Glucose tolerance and insulin action in rats with renovascular hypertension. Hypertension. 1991 Sep; 18(3):341-7. PMID: 1889847.
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    351. Swinburn BA, Boyce VL, Bergman RN, Howard BV, Bogardus C. Deterioration in carbohydrate metabolism and lipoprotein changes induced by modern, high fat diet in Pima Indians and Caucasians. J Clin Endocrinol Metab. 1991 Jul; 73(1):156-65. PMID: 2045466.
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    352. Byerley LO, Heber D, Bergman RN, Dubria M, Chi J. Insulin action and metabolism in patients with head and neck cancer. Cancer. 1991 Jun 01; 67(11):2900-6. PMID: 2025856.
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    353. Youn JH, Bergman RN. Conversion of oral glucose to lactate in dogs. Primary site and relative contribution to blood lactate. Diabetes. 1991 Jun; 40(6):738-47. PMID: 2040389.
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    354. Donovan CM, Halter JB, Bergman RN. Importance of hepatic glucoreceptors in sympathoadrenal response to hypoglycemia. Diabetes. 1991 Jan; 40(1):155-8. PMID: 1849847.
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    355. Donovan CM, Cane P, Bergman RN. Search for the hypoglycemia receptor using the local irrigation approach. Adv Exp Med Biol. 1991; 291:185-96. PMID: 1656712.
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    356. Welch S, Gebhart SS, Bergman RN, Phillips LS. Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab. 1990 Dec; 71(6):1508-18. PMID: 2229309.
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    357. Selam JL, Bergman RN, Raccah D, Jean-Didier N, Lozano J, Charles MA. Determination of portal insulin absorption from peritoneum via novel nonisotopic method. Diabetes. 1990 Nov; 39(11):1361-5. PMID: 2227110.
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    358. Cohen P, Harel C, Bergman R, Daoud D, Pam Z, Barzilai N, Armoni M, Karnieli E. Insulin resistance and acanthosis nigricans: evidence for a postbinding defect in vivo. Metabolism. 1990 Oct; 39(10):1006-11. PMID: 2215248.
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    359. Kahn SE, Klaff LJ, Schwartz MW, Beard JC, Bergman RN, Taborsky GJ, Porte D. Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose. J Clin Endocrinol Metab. 1990 Oct; 71(4):994-1002. PMID: 2205630.
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    360. Schwartz MW, Sipols A, Kahn SE, Lattemann DF, Taborsky GJ, Bergman RN, Woods SC, Porte D. Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid. Am J Physiol. 1990 Sep; 259(3 Pt 1):E378-83. PMID: 2205107.
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    361. Haffner SM, Stern MP, Dunn J, Mobley M, Blackwell J, Bergman RN. Diminished insulin sensitivity and increased insulin response in nonobese, nondiabetic Mexican Americans. Metabolism. 1990 Aug; 39(8):842-7. PMID: 2198435.
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    362. Ader M, Bergman RN. Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol. 1990 Jun; 258(6 Pt 1):E1020-32. PMID: 2193527.
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    363. Cutfield WS, Bergman RN, Menon RK, Sperling MA. The modified minimal model: application to measurement of insulin sensitivity in children. J Clin Endocrinol Metab. 1990 Jun; 70(6):1644-50. PMID: 2189887.
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    364. Youn JH, Bergman RN. Enhancement of hepatic glycogen by gluconeogenic precursors: substrate flux or metabolic control? Am J Physiol. 1990 Jun; 258(6 Pt 1):E899-906. PMID: 2193531.
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    365. Buchanan TA, Metzger BE, Freinkel N, Bergman RN. Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol. 1990 Apr; 162(4):1008-14. PMID: 2183610.
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    366. Bergman RN, Yang YJ, Hope ID, Ader M. The role of the transcapillary insulin transport in the efficiency of insulin action: studies with glucose clamps and the minimal model. Horm Metab Res Suppl. 1990; 24:49-56. PMID: 2272626.
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    367. Bergman RN. Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach. Diabetes. 1989 Dec; 38(12):1512-27. PMID: 2684710.
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    368. Bergman RN, Buchanan TA. Impact of computer simulation on diabetes research and practice. Diabetes Care. 1989 Nov-Dec; 12(10):748-9. PMID: 2612309.
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    369. Yang YJ, Hope ID, Ader M, Bergman RN. Insulin transport across capillaries is rate limiting for insulin action in dogs. J Clin Invest. 1989 Nov; 84(5):1620-8. PMID: 2681272.
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    370. Watanabe RM, Volund A, Roy S, Bergman RN. Prehepatic beta-cell secretion during the intravenous glucose tolerance test in humans: application of a combined model of insulin and C-peptide kinetics. J Clin Endocrinol Metab. 1989 Oct; 69(4):790-7. PMID: 2674187.
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    371. Bergman RN, Hope ID, Yang YJ, Watanabe RM, Meador MA, Youn JH, Ader M. Assessment of insulin sensitivity in vivo: a critical review. Diabetes Metab Rev. 1989 Aug; 5(5):411-29. PMID: 2667927.
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    372. Kahn SE, Beard JC, Schwartz MW, Ward WK, Ding HL, Bergman RN, Taborsky GJ, Porte D. Increased beta-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance. Diabetes. 1989 May; 38(5):562-8. PMID: 2653928.
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    373. Youn JH, Ader M, Bergman RN. Glucose phosphorylation is not rate limiting for accumulation of glycogen from glucose in perfused livers from fasted rats. J Biol Chem. 1989 Jan 05; 264(1):168-72. PMID: 2642472.
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    374. Chen M, Bergman RN, Porte D. Insulin resistance and beta-cell dysfunction in aging: the importance of dietary carbohydrate. J Clin Endocrinol Metab. 1988 Nov; 67(5):951-7. PMID: 3053750.
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    375. Cane P, Haun CK, Evered J, Youn JH, Bergman RN. Response to deep hypoglycemia does not involve glucoreceptors in carotid perfused tissue. Am J Physiol. 1988 Nov; 255(5 Pt 1):E680-7. PMID: 2847539.
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    376. McCulloch DK, Raghu PK, Johnston C, Klaff LJ, Kahn SE, Beard JC, Ward WK, Benson EA, Koerker DJ, Bergman RN. Defects in beta-cell function and insulin sensitivity in normoglycemic streptozocin-treated baboons: a model of preclinical insulin-dependent diabetes. J Clin Endocrinol Metab. 1988 Oct; 67(4):785-92. PMID: 3047163.
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    377. Finegood DT, Bergman RN, Vranic M. Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes. 1988 Aug; 37(8):1025-34. PMID: 3292323.
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    378. Finegood DT, Thomaseth K, Pacini G, Bergman RN. OPSEG: a general routine for smoothing and interpolating discrete biological data. Comput Methods Programs Biomed. 1988 May-Jun; 26(3):289-99. PMID: 3383567.
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    379. Bergman RN. Modeling in nutrition and metabolism. Prog Food Nutr Sci. 1988; 12(3):211-25. PMID: 2855276.
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    380. Yang YJ, Youn JH, Bergman RN. Modified protocols improve insulin sensitivity estimation using the minimal model. Am J Physiol. 1987 Dec; 253(6 Pt 1):E595-602. PMID: 2892414.
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    381. Ader M, Bergman RN. Insulin sensitivity in the intact organism. Baillieres Clin Endocrinol Metab. 1987 Nov; 1(4):879-910. PMID: 3330434.
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    382. Youn JH, Bergman RN. Patterns of glycogen turnover in liver characterized by computer modeling. Am J Physiol. 1987 Oct; 253(4 Pt 1):E360-9. PMID: 3661699.
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    383. Vølund A, Polonsky KS, Bergman RN. Calculated pattern of intraportal insulin appearance without independent assessment of C-peptide kinetics. Diabetes. 1987 Oct; 36(10):1195-202. PMID: 2888696.
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    384. Youn JH, Kaslow HR, Bergman RN. Fructose effect to suppress hepatic glycogen degradation. J Biol Chem. 1987 Aug 25; 262(24):11470-7. PMID: 3114246.
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    385. Finegood DT, Bergman RN, Vranic M. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes. 1987 Aug; 36(8):914-24. PMID: 3297886.
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    386. Johnston C, Raghu P, McCulloch DK, Beard JC, Ward WK, Klaff LJ, McKnight B, Bergman RN, Palmer JP. Beta-cell function and insulin sensitivity in nondiabetic HLA-identical siblings of insulin-dependent diabetics. Diabetes. 1987 Jul; 36(7):829-37. PMID: 3556281.
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    387. Bergman RN, Prager R, Volund A, Olefsky JM. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest. 1987 Mar; 79(3):790-800. PMID: 3546379.
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    388. Ader M, Agajanian T, Finegood DT, Bergman RN. Recombinant deoxyribonucleic acid-derived 22K- and 20K-human growth hormone generate equivalent diabetogenic effects during chronic infusion in dogs. Endocrinology. 1987 Feb; 120(2):725-31. PMID: 3542508.
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    389. Youn JH, Youn MS, Bergman RN. Synergism of glucose and fructose in net glycogen synthesis in perfused rat livers. J Biol Chem. 1986 Dec 05; 261(34):15960-9. PMID: 3023336.
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    390. Heber D, Byerley LO, Chi J, Grosvenor M, Bergman RN, Coleman M, Chlebowski RT. Pathophysiology of malnutrition in the adult cancer patient. Cancer. 1986 Oct 15; 58(8 Suppl):1867-73. PMID: 3093049.
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    391. Pacini G, Bergman RN. MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed. 1986 Oct; 23(2):113-22. PMID: 3640682.
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    392. Marsh BD, Marsh DJ, Bergman RN. Oscillations enhance the efficiency and stability of glucose disposal. Am J Physiol. 1986 May; 250(5 Pt 1):E576-82. PMID: 3518489.
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    393. Beard JC, Bergman RN, Ward WK, Porte D. The insulin sensitivity index in nondiabetic man. Correlation between clamp-derived and IVGTT-derived values. Diabetes. 1986 Mar; 35(3):362-9. PMID: 3512346.
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    394. Cane P, Artal R, Bergman RN. Putative hypothalamic glucoreceptors play no essential role in the response to moderate hypoglycemia. Diabetes. 1986 Mar; 35(3):268-77. PMID: 3005093.
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    395. Ader M, Pacini G, Yang YJ, Bergman RN. Importance of glucose per se to intravenous glucose tolerance. Comparison of the minimal-model prediction with direct measurements. Diabetes. 1985 Nov; 34(11):1092-103. PMID: 2864297.
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    396. Raghu P, Johnston C, Beard JC, Bergman R, McCulloch DK, Palmer JP. Reduced insulin sensitivity in nondiabetic, HLA-identical siblings of insulin-dependent diabetic subjects. Diabetes. 1985 Oct; 34(10):991-4. PMID: 4043555.
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    397. Dimitriadis G, Baker B, Marsh H, Mandarino L, Rizza R, Bergman R, Haymond M, Gerich J. Effect of thyroid hormone excess on action, secretion, and metabolism of insulin in humans. Am J Physiol. 1985 May; 248(5 Pt 1):E593-601. PMID: 3887944.
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    398. Chen M, Bergman RN, Pacini G, Porte D. Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function. J Clin Endocrinol Metab. 1985 Jan; 60(1):13-20. PMID: 3880560.
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    399. Geffner ME, Kaplan SA, Bersch N, Lippe BM, Scott ML, Bergman RN, Golde DW. Diminished in vitro responsiveness of circulating erythroid progenitor cells to insulin as an indicator of insulin resistance. J Clin Endocrinol Metab. 1985 Jan; 60(1):103-8. PMID: 3880558.
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    400. Bergman RN, Finegood DT, Ader M. Assessment of insulin sensitivity in vivo. Endocr Rev. 1985; 6(1):45-86. PMID: 3884329.
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    401. Bergman RN, Ader M, Finegood DT, Pacini G. Extrapancreatic effect of somatostatin infusion to increase glucose clearance. Am J Physiol. 1984 Sep; 247(3 Pt 1):E370-9. PMID: 6148014.
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    402. Finegood DT, Pacini G, Bergman RN. The insulin sensitivity index. Correlation in dogs between values determined from the intravenous glucose tolerance test and the euglycemic glucose clamp. Diabetes. 1984 Apr; 33(4):362-8. PMID: 6368293.
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    403. Finegood DT, Bergman RN. Optimal segments: a method for smoothing tracer data to calculate metabolic fluxes. Am J Physiol. 1983 May; 244(5):E472-9. PMID: 6846533.
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    404. Pacini G, Bergman RN. PACBERG: an adaptive program for controlling the blood sugar. Comput Programs Biomed. 1983 Feb-Apr; 16(1-2):13-20. PMID: 6342930.
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    405. Pacini G, Finegood DT, Bergman RN. A minimal-model-based glucose clamp yielding insulin sensitivity independent of glycemia. Diabetes. 1982 May; 31(5 Pt 1):432-41. PMID: 6759258.
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    406. Bergman RN, Beir JR, Hourigan PM. Intraportal glucose infusion matched to oral glucose absorption. Lack of evidence for "gut factor" involvement in hepatic glucose storage. Diabetes. 1982 Jan; 31(1):27-35. PMID: 7152123.
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    407. Bergman RN, Phillips LS, Cobelli C. Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest. 1981 Dec; 68(6):1456-67. PMID: 7033284.
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    408. Toffolo G, Bergman RN, Finegood DT, Bowden CR, Cobelli C. Quantitative estimation of beta cell sensitivity to glucose in the intact organism: a minimal model of insulin kinetics in the dog. Diabetes. 1980 Dec; 29(12):979-90. PMID: 7002673.
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    409. Taborsky GJ, Bergman RN. Effect of insulin, glucose, and 2-deoxy-glucose infusion into the third cerebral ventricle of conscious dogs on plasma insulin, glucose, and free fatty acids. Diabetes. 1980 Apr; 29(4):278-83. PMID: 6987116.
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    410. Bowden CR, Bergman RN, Marsh DJ. Cause of glucose oscillations during glucose infusion: periodic variation in glucose uptake. Am J Physiol. 1980 Apr; 238(4):E395-407. PMID: 6990778.
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    411. Bergman RN, Cobelli C. Minimal modeling, partition analysis, and the estimation of insulin sensitivity. Fed Proc. 1980 Jan; 39(1):110-5. PMID: 6985867.
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    412. Bergman RN, Ider YZ, Bowden CR, Cobelli C. Quantitative estimation of insulin sensitivity. Am J Physiol. 1979 Jun; 236(6):E667-77. PMID: 443421.
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    413. Bowden CR, Bergman RN. Caval occlusion technique for hepatic venous sampling: a new approach to estimating splanchnic substrate balance in conscious dogs. Metabolism. 1979 May; 28(5):562-7. PMID: 449697.
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    414. El-Refai M, Bergman RN. Glucagon-stimulated glycogenolysis: time-dependent sensitivity to insulin. Am J Physiol. 1979 Mar; 236(3):E246-54. PMID: 426055.
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    415. Bergman RN, Hechter O. Neurohypophyseal hormone-responsive renal adenylate cyclase. IV. A random-hit matrix model for coupline in a hormone-sensitive adenylate cyclase system. J Biol Chem. 1978 May 10; 253(9):3238-50. PMID: 641067.
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    416. Bergman RN. Integrated control of hepatic glucose metabolism. Fed Proc. 1977 Feb; 36(2):265-70. PMID: 190047.
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    417. El-Refai M, Bergman RN. Simulation study of control of hepatic glycogen synthesis by glucose and insulin. Am J Physiol. 1976 Nov; 231(5 Pt. 1):1608-19. PMID: 187069.
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    418. Bergman RN, Refai ME. Dynamic control of hepatic glucose metabolism: Studies by experiment and computer simulation. Ann Biomed Eng. 1975 Dec; 3(4):411-32. PMID: 176905.
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    419. Bergman RN, Bucolo RJ. Interaction of insulin and glucose in the control of hepatic glucose balance. Am J Physiol. 1974 Dec; 227(6):1314-22. PMID: 4440776.
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    420. Bucolo RJ, Bergman RN, Marsh DJ, Yates FE. Dynamics of glucose autoregulation in the isolated, blood-perfused canine liver. Am J Physiol. 1974 Jul; 227(1):209-17. PMID: 4843372.
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