Robert Thompson Clubb

Title(s)Professor, Chemistry and Biochemistry
SchoolCollege of Letters and Science
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    Research Summary: Bacterial pathogens mount successful infections by displaying virulence factors that enable them to adhere to host tissues, evade the immune response, invade host cells and acquire essential nutrients. I am interested in understanding the molecular mechanisms that underpin virulence factor display and function, and I hope to translate my laboratory’s research findings into practical applications.
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    Molecular basis of heme scavenging by Gram-positive bacteria
    NIH R01AI161828Jan 19, 2021 - Dec 31, 2026
    Role: Principal Investigator
    Development of a cell-based assay to discover new bacterial anti-infective agents
    NIH R01AI121360May 10, 2016 - Apr 30, 2020
    Role: Principal Investigator
    Bruker Avance III Console and QCI Cryoprobe for a 600 MHz NMR Spectrometer
    NIH S10OD016336May 1, 2014 - Apr 30, 2016
    Role: Principal Investigator
    ITC: Isothermal Titration Calorimeter
    NIH S10OD011994Apr 1, 2012 - Mar 31, 2013
    Role: Principal Investigator
    Bruker 800 MHz TCI CryoProbe
    NIH S10RR022471Apr 1, 2006 - Mar 31, 2008
    Role: Principal Investigator
    Cell surface polymer display in Gram-positive bacteria
    NIH R01AI052217Jun 1, 2002 - Apr 30, 2022
    Role: Principal Investigator
    Molecular assembly in transposon and viral recombination
    NIH R01GM057487Jun 1, 1998 - Aug 31, 2008
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Insight into the autoproteolysis mechanism of the RsgI9 anti-σ factor from Clostridium thermocellum. Proteins. 2024 Apr 10. Takayesu A, Mahoney BJ, Goring AK, Jessup T, Ogorzalek Loo RR, Loo JA, Clubb RT. PMID: 38597224.
      View in: PubMed   Mentions:
    2. Quantifying the Kinetics of Pilus-Specific Sortase-Catalyzed Crosslinking Using High-Performance Liquid Chromatography. Methods Mol Biol. 2024; 2727:135-143. Cheung NA, Song M, Sue CK, Clubb RT. PMID: 37815714.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens. J Inorg Biochem. 2023 12; 249:112368. Mahoney BJ, Goring AK, Wang Y, Dasika P, Zhou A, Grossbard E, Cascio D, Loo JA, Clubb RT. PMID: 37729854.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. The basal and major pilins in the Corynebacterium diphtheriae SpaA pilus adopt similar structures that competitively react with the pilin polymerase. Biopolymers. 2024 Jan; 115(1):e23539. Sue CK, Cheung NA, Mahoney BJ, McConnell SA, Scully JM, Fu JY, Chang C, Ton-That H, Loo JA, Clubb RT. PMID: 37227047.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. The Basal and Major Pilins in the Corynebacterium diphtheriae SpaA Pilus Adopt Similar Structures that Competitively React with the Pilin Polymerase. bioRxiv. 2023 Feb 23. Sue CK, Cheung NA, Mahoney BJ, McConnell SA, Scully JM, Fu JY, Chang C, Ton-That H, Loo JA, Clubb RT. PMID: 36865106; PMCID: PMC9980135.
      View in: PubMed   Mentions:
    6. The Shr receptor from Streptococcus pyogenes uses a cap and release mechanism to acquire heme-iron from human hemoglobin. Proc Natl Acad Sci U S A. 2023 01 31; 120(5):e2211939120. Macdonald R, Mahoney BJ, Soule J, Goring AK, Ford J, Loo JA, Cascio D, Clubb RT. PMID: 36693107; PMCID: PMC9945957.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Directed Inter-domain Motions Enable the IsdH Staphylococcus aureus Receptor to Rapidly Extract Heme from Human Hemoglobin. J Mol Biol. 2022 06 30; 434(12):167623. Clayton J, Ellis-Guardiola K, Mahoney BJ, Soule J, Liu W, Clubb RT, Wereszczynski J. PMID: 35533763; PMCID: PMC9326902.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. The structure of the Clostridium thermocellum RsgI9 ectodomain provides insight into the mechanism of biomass sensing. Proteins. 2022 07; 90(7):1457-1467. Mahoney BJ, Takayesu A, Zhou A, Cascio D, Clubb RT. PMID: 35194841; PMCID: PMC9177573.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    9. Insight into the molecular basis of substrate recognition by the wall teichoic acid glycosyltransferase TagA. J Biol Chem. 2022 02; 298(2):101464. Martinez OE, Mahoney BJ, Goring AK, Yi SW, Tran DP, Cascio D, Phillips ML, Muthana MM, Chen X, Jung ME, Loo JA, Clubb RT. PMID: 34864059; PMCID: PMC8784642.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    10. Methods for the Extraction of Heme Prosthetic Groups from Hemoproteins. Bio Protoc. 2021 09 20; 11(18):e4156. Ellis-Guardiola K, Soule J, Clubb RT. PMID: 34692906; PMCID: PMC8481031.
      View in: PubMed   Mentions: 3  
    11. Sortase-assembled pili in Corynebacterium diphtheriae are built using a latch mechanism. Proc Natl Acad Sci U S A. 2021 03 23; 118(12). McConnell SA, McAllister RA, Amer BR, Mahoney BJ, Sue CK, Chang C, Ton-That H, Clubb RT. PMID: 33723052; PMCID: PMC7999877.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    12. NEAr Transporter (NEAT) Domains: Unique Surface Displayed Heme Chaperones That Enable Gram-Positive Bacteria to Capture Heme-Iron From Hemoglobin. Front Microbiol. 2020; 11:607679. Ellis-Guardiola K, Mahoney BJ, Clubb RT. PMID: 33488548; PMCID: PMC7815599.
      View in: PubMed   Mentions: 8  
    13. Kinetics and Optimization of the Lysine-Isopeptide Bond Forming Sortase Enzyme from Corynebacterium diphtheriae. Bioconjug Chem. 2020 06 17; 31(6):1624-1634. Sue CK, McConnell SA, Ellis-Guardiola K, Muroski JM, McAllister RA, Yu J, Alvarez AI, Chang C, Ogorzalek Loo RR, Loo JA, Ton-That H, Clubb RT. PMID: 32396336; PMCID: PMC8153732.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    14. A Cell-based Screen in Actinomyces oris to Identify Sortase Inhibitors. Sci Rep. 2020 05 22; 10(1):8520. Gosschalk JE, Chang C, Sue CK, Siegel SD, Wu C, Kattke MD, Yi SW, Damoiseaux R, Jung ME, Ton-That H, Clubb RT. PMID: 32444661; PMCID: PMC7244523.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    15. Designed Protein Cages as Scaffolds for Building Multienzyme Materials. ACS Synth Biol. 2020 02 21; 9(2):381-391. McConnell SA, Cannon KA, Morgan C, McAllister R, Amer BR, Clubb RT, Yeates TO. PMID: 31922719.
      View in: PubMed   Mentions: 17     Fields:    
    16. The Staphylococcus aureus IsdH Receptor Forms a Dynamic Complex with Human Hemoglobin that Triggers Heme Release via Two Distinct Hot Spots. J Mol Biol. 2020 02 14; 432(4):1064-1082. Ellis-Guardiola K, Clayton J, Pham C, Mahoney BJ, Wereszczynski J, Clubb RT. PMID: 31881209; PMCID: PMC7309296.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    17. Cell-to-cell interaction requires optimal positioning of a pilus tip adhesin modulated by gram-positive transpeptidase enzymes. Proc Natl Acad Sci U S A. 2019 09 03; 116(36):18041-18049. Chang C, Wu C, Osipiuk J, Siegel SD, Zhu S, Liu X, Joachimiak A, Clubb RT, Das A, Ton-That H. PMID: 31427528; PMCID: PMC6731673.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    18. NMR experiments redefine the hemoglobin binding properties of bacterial NEAr-iron Transporter domains. Protein Sci. 2019 08; 28(8):1513-1523. Macdonald R, Mahoney BJ, Ellis-Guardiola K, Maresso A, Clubb RT. PMID: 31120610; PMCID: PMC6635774.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    19. Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function. J Lipid Res. 2019 07; 60(7):1293-1310. Tsui HS, Pham NVB, Amer BR, Bradley MC, Gosschalk JE, Gallagher-Jones M, Ibarra H, Clubb RT, Blaby-Haas CE, Clarke CF. PMID: 31048406; PMCID: PMC6602128.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    20. Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria. PLoS Pathog. 2019 04; 15(4):e1007723. Kattke MD, Gosschalk JE, Martinez OE, Kumar G, Gale RT, Cascio D, Sawaya MR, Philips M, Brown ED, Clubb RT. PMID: 31002736; PMCID: PMC6493773.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    21. Structure and Mechanism of LcpA, a Phosphotransferase That Mediates Glycosylation of a Gram-Positive Bacterial Cell Wall-Anchored Protein. mBio. 2019 02 19; 10(1). Siegel SD, Amer BR, Wu C, Sawaya MR, Gosschalk JE, Clubb RT, Ton-That H. PMID: 30782654; PMCID: PMC6381275.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    22. The Streptococcus pyogenes Shr protein captures human hemoglobin using two structurally unique binding domains. J Biol Chem. 2018 11 23; 293(47):18365-18377. Macdonald R, Cascio D, Collazo MJ, Phillips M, Clubb RT. PMID: 30301765; PMCID: PMC6254355.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    23. Protein Labeling via a Specific Lysine-Isopeptide Bond Using the Pilin Polymerizing Sortase from Corynebacterium diphtheriae. J Am Chem Soc. 2018 07 11; 140(27):8420-8423. McConnell SA, Amer BR, Muroski J, Fu J, Chang C, Ogorzalek Loo RR, Loo JA, Osipiuk J, Ton-That H, Clubb RT. PMID: 29927249; PMCID: PMC6230430.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    24. In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking. Proc Natl Acad Sci U S A. 2018 06 12; 115(24):E5477-E5486. Chang C, Amer BR, Osipiuk J, McConnell SA, Huang IH, Hsieh V, Fu J, Nguyen HH, Muroski J, Flores E, Ogorzalek Loo RR, Loo JA, Putkey JA, Joachimiak A, Das A, Clubb RT, Ton-That H. PMID: 29844180; PMCID: PMC6004493.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    25. Stabilizing displayed proteins on vegetative Bacillus subtilis cells. Appl Microbiol Biotechnol. 2018 Aug; 102(15):6547-6565. Huang GL, Gosschalk JE, Kim YS, Ogorzalek Loo RR, Clubb RT. PMID: 29796970; PMCID: PMC6289300.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    26. Energetics underlying hemin extraction from human hemoglobin by Staphylococcus aureus. J Biol Chem. 2018 05 04; 293(18):6942-6957. Sjodt M, Macdonald R, Marshall JD, Clayton J, Olson JS, Phillips M, Gell DA, Wereszczynski J, Clubb RT. PMID: 29540481; PMCID: PMC5936817.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    27. Sortase Transpeptidases: Structural Biology and Catalytic Mechanism. Adv Protein Chem Struct Biol. 2017; 109:223-264. Jacobitz AW, Kattke MD, Wereszczynski J, Clubb RT. PMID: 28683919; PMCID: PMC5718342.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    28. Nitroxide Labeling of Proteins and the Determination of Paramagnetic Relaxation Derived Distance Restraints for NMR Studies. Bio Protoc. 2017 Apr 05; 7(7). Sjodt M, Clubb RT. PMID: 28616445; PMCID: PMC5467883.
      View in: PubMed   Mentions: 21  
    29. NMR structure-based optimization of Staphylococcus aureus sortase A pyridazinone inhibitors. Chem Biol Drug Des. 2017 Sep; 90(3):327-344. Chan AH, Yi SW, Weiner EM, Amer BR, Sue CK, Wereszczynski J, Dillen CA, Senese S, Torres JZ, McCammon JA, Miller LS, Jung ME, Clubb RT. PMID: 28160417; PMCID: PMC5540818.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    30. Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal. PLoS One. 2016; 11(12):e0167763. Kattke MD, Chan AH, Duong A, Sexton DL, Sawaya MR, Cascio D, Elliot MA, Clubb RT. PMID: 27936128; PMCID: PMC5148588.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    31. The "Lid" in the Streptococcus pneumoniae SrtC1 Sortase Adopts a Rigid Structure that Regulates Substrate Access to the Active Site. J Phys Chem B. 2016 08 25; 120(33):8302-12. Jacobitz AW, Naziga EB, Yi SW, McConnell SA, Peterson R, Jung ME, Clubb RT, Wereszczynski J. PMID: 27109553; PMCID: PMC5097456.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    32. Rapid addition of unlabeled silent solubility tags to proteins using a new substrate-fused sortase reagent. J Biomol NMR. 2016 Mar; 64(3):197-205. Amer BR, Macdonald R, Jacobitz AW, Liauw B, Clubb RT. PMID: 26852413; PMCID: PMC5110246.
      View in: PubMed   Mentions: 7     Fields:    
    33. Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication. J Virol. 2015 Dec; 89(23):12058-69. Tekeste SS, Wilkinson TA, Weiner EM, Xu X, Miller JT, Le Grice SF, Clubb RT, Chow SA. PMID: 26401032; PMCID: PMC4645309.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    34. Structure of the Bacillus anthracis Sortase A Enzyme Bound to Its Sorting Signal: A FLEXIBLE AMINO-TERMINAL APPENDAGE MODULATES SUBSTRATE ACCESS. J Biol Chem. 2015 Oct 16; 290(42):25461-74. Chan AH, Yi SW, Terwilliger AL, Maresso AW, Jung ME, Clubb RT. PMID: 26324714; PMCID: PMC4646193.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    35. Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting. Sci Rep. 2015 Aug 27; 5:13476. Zilbermintz L, Leonardi W, Jeong SY, Sjodt M, McComb R, Ho CL, Retterer C, Gharaibeh D, Zamani R, Soloveva V, Bavari S, Levitin A, West J, Bradley KA, Clubb RT, Cohen SN, Gupta V, Martchenko M. PMID: 26310922; PMCID: PMC4550849.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    36. Solution structure of the PhoP DNA-binding domain from Mycobacterium tuberculosis. J Biomol NMR. 2015 Sep; 63(1):111-7. Macdonald R, Sarkar D, Amer BR, Clubb RT. PMID: 26209027; PMCID: PMC4714862.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    37. The structure of haemoglobin bound to the haemoglobin receptor IsdH from Staphylococcus aureus shows disruption of the native α-globin haem pocket. Acta Crystallogr D Biol Crystallogr. 2015 Jun; 71(Pt 6):1295-306. Dickson CF, Jacques DA, Clubb RT, Guss JM, Gell DA. PMID: 26057669; PMCID: PMC8518021.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    38. The PRE-Derived NMR Model of the 38.8-kDa Tri-Domain IsdH Protein from Staphylococcus aureus Suggests That It Adaptively Recognizes Human Hemoglobin. J Mol Biol. 2016 Mar 27; 428(6):1107-1129. Sjodt M, Macdonald R, Spirig T, Chan AH, Dickson CF, Fabian M, Olson JS, Gell DA, Clubb RT. PMID: 25687963; PMCID: PMC4537403.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    39. Native top-down mass spectrometry for the structural characterization of human hemoglobin. Eur J Mass Spectrom (Chichester). 2015; 21(3):221-31. Zhang J, Reza Malmirchegini G, Clubb RT, Loo JA. PMID: 26307702; PMCID: PMC4731028.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    40. A sweet new role for LCP enzymes in protein glycosylation. Mol Microbiol. 2014 Dec; 94(6):1197-200. Amer BR, Clubb RT. PMID: 25302626; PMCID: PMC4262582.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    41. Novel mechanism of hemin capture by Hbp2, the hemoglobin-binding hemophore from Listeria monocytogenes. J Biol Chem. 2014 Dec 12; 289(50):34886-99. Malmirchegini GR, Sjodt M, Shnitkind S, Sawaya MR, Rosinski J, Newton SM, Klebba PE, Clubb RT. PMID: 25315777; PMCID: PMC4263887.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    42. A robust approach to correct for pronounced errors in temperature measurements by controlling radiation damping feedback fields in solution NMR. J Magn Reson. 2014 Nov; 248:19-22. Wolahan SM, Li Z, Hsu CH, Huang SJ, Clubb R, Hwang LP, Lin YY. PMID: 25299766.
      View in: PubMed   Mentions:    Fields:    
    43. Trichomonas vaginalis homolog of macrophage migration inhibitory factor induces prostate cell growth, invasiveness, and inflammatory responses. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8179-84. Twu O, Dessí D, Vu A, Mercer F, Stevens GC, de Miguel N, Rappelli P, Cocco AR, Clubb RT, Fiori PL, Johnson PJ. PMID: 24843155; PMCID: PMC4050605.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    44. Structural and computational studies of the Staphylococcus aureus sortase B-substrate complex reveal a substrate-stabilized oxyanion hole. J Biol Chem. 2014 Mar 28; 289(13):8891-902. Jacobitz AW, Wereszczynski J, Yi SW, Amer BR, Huang GL, Nguyen AV, Sawaya MR, Jung ME, McCammon JA, Clubb RT. PMID: 24519933; PMCID: PMC3979406.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    45. Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus. J Biol Chem. 2014 Mar 07; 289(10):6728-6738. Dickson CF, Kumar KK, Jacques DA, Malmirchegini GR, Spirig T, Mackay JP, Clubb RT, Guss JM, Gell DA. PMID: 24425866; PMCID: PMC3945333.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    46. Engineering microbial surfaces to degrade lignocellulosic biomass. Bioengineered. 2014 Mar-Apr; 5(2):96-106. Huang GL, Anderson TD, Clubb RT. PMID: 24430239; PMCID: PMC4049913.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    47. Discovery of Staphylococcus aureus sortase A inhibitors using virtual screening and the relaxed complex scheme. Chem Biol Drug Des. 2013 Oct; 82(4):418-28. Chan AH, Wereszczynski J, Amer BR, Yi SW, Jung ME, McCammon JA, Clubb RT. PMID: 23701677; PMCID: PMC3841297.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    48. Axial ligand replacement mechanism in heme transfer from streptococcal heme-binding protein Shp to HtsA of the HtsABC transporter. Biochemistry. 2013 Sep 17; 52(37):6537-47. Ran Y, Malmirchegini GR, Clubb RT, Lei B. PMID: 23980583; PMCID: PMC3815476.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    49. The binding mechanism, multiple binding modes, and allosteric regulation of Staphylococcus aureus Sortase A probed by molecular dynamics simulations. Protein Sci. 2012 Dec; 21(12):1858-71. Kappel K, Wereszczynski J, Clubb RT, McCammon JA. PMID: 23023444; PMCID: PMC3575916.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    50. Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme. J Biol Chem. 2013 Jan 11; 288(2):1065-78. Spirig T, Malmirchegini GR, Zhang J, Robson SA, Sjodt M, Liu M, Krishna Kumar K, Dickson CF, Gell DA, Lei B, Loo JA, Clubb RT. PMID: 23132864; PMCID: PMC3542992.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    51. Solution structure of the sortase required for efficient production of infectious Bacillus anthracis spores. Biochemistry. 2012 Oct 09; 51(40):7953-63. Robson SA, Jacobitz AW, Phillips ML, Clubb RT. PMID: 22974341; PMCID: PMC3971844.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    52. Preparation and optimization of protein-DNA complexes suitable for detailed NMR studies. Methods Mol Biol. 2012; 831:219-32. Sam MD, Clubb RT. PMID: 22167677; PMCID: PMC3590071.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    53. Backbone 1H, 13C and 15N resonance assignments of the 39 kDa staphylococcal hemoglobin receptor IsdH. Biomol NMR Assign. 2012 Oct; 6(2):169-72. Spirig T, Clubb RT. PMID: 22101872; PMCID: PMC3590065.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    54. Sortase enzymes in Gram-positive bacteria. Mol Microbiol. 2011 Dec; 82(5):1044-59. Spirig T, Weiner EM, Clubb RT. PMID: 22026821; PMCID: PMC3590066.
      View in: PubMed   Mentions: 128     Fields:    Translation:Cells
    55. Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH. J Biol Chem. 2011 Nov 04; 286(44):38439-38447. Krishna Kumar K, Jacques DA, Pishchany G, Caradoc-Davies T, Spirig T, Malmirchegini GR, Langley DB, Dickson CF, Mackay JP, Clubb RT, Skaar EP, Guss JM, Gell DA. PMID: 21917915; PMCID: PMC3207429.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    56. Transient weak protein-protein complexes transfer heme across the cell wall of Staphylococcus aureus. J Am Chem Soc. 2011 Sep 14; 133(36):14176-9. Villareal VA, Spirig T, Robson SA, Liu M, Lei B, Clubb RT. PMID: 21834592; PMCID: PMC3174093.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    57. Site-directed spin labeling electron paramagnetic resonance study of the ORF1 protein from a mouse L1 retrotransposon. Protein Sci. 2011 Jul; 20(7):1231-43. Januszyk K, Fleissner MR, Atchabahian L, Shieh FK, Altenbach C, Martin SL, Guo F, Hubbell WL, Clubb RT. PMID: 21563223; PMCID: PMC3149196.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    58. Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen binding. Biochemistry. 2010 Aug 31; 49(34):7403-10. Ramey JD, Villareal VA, Ng C, Ward SC, Xiong JP, Clubb RT, Bradley KA. PMID: 20690680; PMCID: PMC2942075.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    59. A heteronuclear zero quantum coherence Nz-exchange experiment that resolves resonance overlap and its application to measure the rates of heme binding to the IsdC protein. J Am Chem Soc. 2010 Jul 21; 132(28):9522-3. Robson SA, Peterson R, Bouchard LS, Villareal VA, Clubb RT. PMID: 20578738; PMCID: PMC2912433.
      View in: PubMed   Mentions: 5     Fields:    
    60. Structure of the dimerization domain of DiGeorge critical region 8. Protein Sci. 2010 Jul; 19(7):1354-65. Senturia R, Faller M, Yin S, Loo JA, Cascio D, Sawaya MR, Hwang D, Clubb RT, Guo F. PMID: 20506313; PMCID: PMC2974827.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    61. The Sortase A enzyme that attaches proteins to the cell wall of Bacillus anthracis contains an unusual active site architecture. J Biol Chem. 2010 Jul 23; 285(30):23433-43. Weiner EM, Robson S, Marohn M, Clubb RT. PMID: 20489200; PMCID: PMC2906334.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    62. Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. Bioorg Med Chem. 2009 Oct 15; 17(20):7174-85. Suree N, Yi SW, Thieu W, Marohn M, Damoiseaux R, Chan A, Jung ME, Clubb RT. PMID: 19781950; PMCID: PMC2888031.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    63. The structure of the Staphylococcus aureus sortase-substrate complex reveals how the universally conserved LPXTG sorting signal is recognized. J Biol Chem. 2009 Sep 04; 284(36):24465-77. Suree N, Liew CK, Villareal VA, Thieu W, Fadeev EA, Clemens JJ, Jung ME, Clubb RT. PMID: 19592495; PMCID: PMC2782039.
      View in: PubMed   Mentions: 81     Fields:    Translation:Cells
    64. NMR structure of the amino-terminal domain of the lambda integrase protein in complex with DNA: immobilization of a flexible tail facilitates beta-sheet recognition of the major groove. J Mol Biol. 2009 May 15; 388(4):682-90. Fadeev EA, Sam MD, Clubb RT. PMID: 19324050; PMCID: PMC2739574.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    65. Identifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase. J Biol Chem. 2009 Mar 20; 284(12):7931-9. Wilkinson TA, Januszyk K, Phillips ML, Tekeste SS, Zhang M, Miller JT, Le Grice SF, Clubb RT, Chow SA. PMID: 19150986; PMCID: PMC2658086.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    66. Functionally distinct NEAT (NEAr Transporter) domains within the Staphylococcus aureus IsdH/HarA protein extract heme from methemoglobin. J Biol Chem. 2009 Jan 09; 284(2):1166-76. Pilpa RM, Robson SA, Villareal VA, Wong ML, Phillips M, Clubb RT. PMID: 18984582; PMCID: PMC2613621.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
    67. The IsdC protein from Staphylococcus aureus uses a flexible binding pocket to capture heme. J Biol Chem. 2008 Nov 14; 283(46):31591-600. Villareal VA, Pilpa RM, Robson SA, Fadeev EA, Clubb RT. PMID: 18715872; PMCID: PMC2581589.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    68. Biochemistry. How some pili pull. Science. 2007 Dec 07; 318(5856):1558-9. Yeates TO, Clubb RT. PMID: 18063774.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    69. Identification and solution structure of a highly conserved C-terminal domain within ORF1p required for retrotransposition of long interspersed nuclear element-1. J Biol Chem. 2007 Aug 24; 282(34):24893-904. Januszyk K, Li PW, Villareal V, Branciforte D, Wu H, Xie Y, Feigon J, Loo JA, Martin SL, Clubb RT. PMID: 17569664.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    70. Structure of the cooperative Xis-DNA complex reveals a micronucleoprotein filament that regulates phage lambda intasome assembly. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2109-14. Abbani MA, Papagiannis CV, Sam MD, Cascio D, Johnson RC, Clubb RT. PMID: 17287355; PMCID: PMC1893000.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    71. Fis targets assembly of the Xis nucleoprotein filament to promote excisive recombination by phage lambda. J Mol Biol. 2007 Mar 23; 367(2):328-43. Papagiannis CV, Sam MD, Abbani MA, Yoo D, Cascio D, Clubb RT, Johnson RC. PMID: 17275024; PMCID: PMC1852488.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    72. Crystallization, dehydration and preliminary X-ray analysis of excisionase (Xis) proteins cooperatively bound to DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 01; 62(Pt 8):825-8. Sam MD, Abbani MA, Cascio D, Johnson RC, Clubb RT. PMID: 16880568; PMCID: PMC2242933.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    73. Solution structure of the NEAT (NEAr Transporter) domain from IsdH/HarA: the human hemoglobin receptor in Staphylococcus aureus. J Mol Biol. 2006 Jul 07; 360(2):435-47. Pilpa RM, Fadeev EA, Villareal VA, Wong ML, Phillips M, Clubb RT. PMID: 16762363.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    74. Synthesis of (2R,3S) 3-amino-4-mercapto-2-butanol, a threonine analogue for covalent inhibition of sortases. Bioorg Med Chem Lett. 2005 Nov 15; 15(22):5076-9. Jung ME, Clemens JJ, Suree N, Liew CK, Pilpa R, Campbell DO, Clubb RT. PMID: 16169722.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    75. Staphylococcus aureus Sortase A transpeptidase. Calcium promotes sorting signal binding by altering the mobility and structure of an active site loop. J Biol Chem. 2006 Jan 20; 281(3):1817-26. Naik MT, Suree N, Ilangovan U, Liew CK, Thieu W, Campbell DO, Clemens JJ, Jung ME, Clubb RT. PMID: 16269411.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    76. NMR resonance assignments of the NEAT (NEAr Transporter) domain from the Staphylococcus aureus IsdH protein. J Biomol NMR. 2005 Oct; 33(2):137. Pilpa RM, Clubb RT. PMID: 16258836.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    77. Compensating increases in protein backbone flexibility occur when the Dead ringer AT-rich interaction domain (ARID) binds DNA: a nitrogen-15 relaxation study. Protein Sci. 2005 May; 14(5):1140-50. Iwahara J, Peterson RD, Clubb RT. PMID: 15802641; PMCID: PMC2253272.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    78. The structure of the excisionase (Xis) protein from conjugative transposon Tn916 provides insights into the regulation of heterobivalent tyrosine recombinases. J Mol Biol. 2005 Mar 18; 347(1):11-25. Abbani M, Iwahara M, Clubb RT. PMID: 15733914.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    79. Localization and mutagenesis of the sorting signal binding site on sortase A from Staphylococcus aureus. FEBS Lett. 2004 Jul 30; 571(1-3):221-6. Liew CK, Smith BT, Pilpa R, Suree N, Ilangovan U, Connolly KM, Jung ME, Clubb RT. PMID: 15280046.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    80. A comparative genome analysis identifies distinct sorting pathways in gram-positive bacteria. Infect Immun. 2004 May; 72(5):2710-22. Comfort D, Clubb RT. PMID: 15102780; PMCID: PMC387863.
      View in: PubMed   Mentions: 88     Fields:    Translation:Cells
    81. Crystal structure of the excisionase-DNA complex from bacteriophage lambda. J Mol Biol. 2004 Apr 23; 338(2):229-40. Sam MD, Cascio D, Johnson RC, Clubb RT. PMID: 15066428.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    82. Identification of the lambda integrase surface that interacts with Xis reveals a residue that is also critical for Int dimer formation. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8176-81. Warren D, Sam MD, Manley K, Sarkar D, Lee SY, Abbani M, Wojciak JM, Clubb RT, Landy A. PMID: 12832614; PMCID: PMC166202.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    83. Crystallization and preliminary X-ray crystallographic analysis of the excisionase-DNA complex from bacteriophage lambda. Acta Crystallogr D Biol Crystallogr. 2003 Jul; 59(Pt 7):1238-40. Sam MD, Cascio D, Johnson R, Clubb RT. PMID: 12832771.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    84. Sortase from Staphylococcus aureus does not contain a thiolate-imidazolium ion pair in its active site. J Biol Chem. 2003 Sep 05; 278(36):34061-5. Connolly KM, Smith BT, Pilpa R, Ilangovan U, Jung ME, Clubb RT. PMID: 12824164.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    85. Energetics of sequence-specific protein-DNA association: binding of integrase Tn916 to its target DNA. Biochemistry. 2003 Apr 01; 42(12):3481-91. Milev S, Gorfe AA, Karshikoff A, Clubb RT, Bosshard HR, Jelesarov I. PMID: 12653552.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    86. Energetics of sequence-specific protein-DNA association: conformational stability of the DNA binding domain of integrase Tn916 and its cognate DNA duplex. Biochemistry. 2003 Apr 01; 42(12):3492-502. Milev S, Gorfe AA, Karshikoff A, Clubb RT, Bosshard HR, Jelesarov I. PMID: 12653553.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    87. Regulation of directionality in bacteriophage lambda site-specific recombination: structure of the Xis protein. J Mol Biol. 2002 Dec 06; 324(4):791-805. Sam MD, Papagiannis CV, Connolly KM, Corselli L, Iwahara J, Lee J, Phillips M, Wojciak JM, Johnson RC, Clubb RT. PMID: 12460578.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    88. Xis protein binding to the left arm stimulates excision of conjugative transposon Tn916. J Bacteriol. 2002 Apr; 184(8):2088-99. Connolly KM, Iwahara M, Clubb RT. PMID: 11914339; PMCID: PMC134961.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    89. Arm-site binding by lambda -integrase: solution structure and functional characterization of its amino-terminal domain. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3434-9. Wojciak JM, Sarkar D, Landy A, Clubb RT. PMID: 11904406; PMCID: PMC122541.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    90. The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA. EMBO J. 2002 Mar 01; 21(5):1197-209. Iwahara J, Iwahara M, Daughdrill GW, Ford J, Clubb RT. PMID: 11867548; PMCID: PMC125891.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
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