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Gottlieb, Roberta A

Title(s)Professor-in-Residence, Medicine
SchoolCardiology
Phone(424) 315-2556
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of the Dynamic Proteome after Ischemic Injury
    NIH/NHLBI R01HL144509Feb 1, 2019 - Jan 31, 2023
    Role: Co-Principal Investigator
    Mitochondrial Turnover in the Human Heart
    NIH/NHLBI R01HL132075Dec 15, 2016 - Nov 30, 2020
    Role: Principal Investigator
    Mitochondrial Quality in Cardioprotection: Overcoming Co-Morbidities
    NIH/NHLBI P01HL112730Jul 1, 2013 - Jun 30, 2018
    Role: Principal Investigator
    In Vivo Imaging of Heart Disease and Host-Pathogen Processes
    NIH/NCRR S10RR025596Mar 18, 2010 - Mar 17, 2012
    Role: Principal Investigator
    Subcellular Regulation of Autophagic Flux in Cardiomyocytes and the Heart
    NIH/NIA R01AG033283Jul 1, 2009 - Oct 31, 2010
    Role: Principal Investigator
    Rescue and Role of Complex I in myocardial ischemic injury
    NIH/NHLBI R01HL060590Jun 1, 2009 - Oct 31, 2010
    Role: Principal Investigator
    Juvenile mouse model of delayed anthracycline cardiotoxicity
    NIH/NHLBI R01HL092136Dec 19, 2008 - Nov 30, 2013
    Role: Principal Investigator
    Cytochrome P450 in Reperfusion Injury
    NIH/NHLBI R01HL071091Dec 1, 2003 - Nov 30, 2008
    Role: Principal Investigator
    Bid-Mediated Cytochrome c Release from Mitochondria
    NIH/NIA R01AG021568Aug 1, 2003 - Jul 31, 2009
    Role: Principal Investigator
    MITOCHONDRIAL ROLE IN CASPASE PROCESSING AND ACTIVATION
    NIH/NHLBI R01HL061518Jan 1, 1999 - Dec 31, 2004
    Role: Principal Investigator
    MECHANISMS OF APOPTOSIS IN BLOOD CELLS
    NIH/NIA R01AG013501Feb 10, 1996 - Jan 31, 2002
    Role: Principal Investigator
    PROGRAMMED CELL DEATH IN NEUTROPHILS
    NIH/NIAID K08AI001345Apr 1, 1995 - Mar 31, 1998
    Role: Principal Investigator
    Autophagy, Adenosine and Pyruvate Protection During Heart Surgery
    NIH/NHLBI R01HL034579Jan 1, 1987 - Nov 30, 1989
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Campos JC, Baehr LM, Ferreira ND, Bozi LHM, Andres AM, Ribeiro MAC, Gottlieb RA, Bodine SC, Ferreira JCB. ß2 -adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy. FASEB J. 2020 Feb 28. PMID: 32112488.
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    2. Thomas A, Marek-Iannucci S, Tucker KC, Andres AM, Gottlieb RA. Decrease of Cardiac Parkin Protein in Obese Mice. Front Cardiovasc Med. 2019; 6:191. PMID: 32039238.
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    3. Gottlieb RA, Bhowmick NA. Pushing the Heart Over a KLF(15). J Am Coll Cardiol. 2019 Oct 08; 74(14):1820-1822. PMID: 31582142.
      View in: PubMed
    4. Lyra-Leite DM, Andres AM, Cho N, Petersen AP, Ariyasinghe NR, Kim SS, Gottlieb RA, McCain ML. Matrix-guided control of mitochondrial function in cardiac myocytes. Acta Biomater. 2019 10 01; 97:281-295. PMID: 31401347.
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    5. Piplani H, Marek-Iannucci S, Sin J, Hou J, Takahashi T, Sharma A, de Freitas Germano J, Waldron RT, Saadaeijahromi H, Song Y, Gulla A, Wu B, Lugea A, Andres AM, Gaisano HY, Gottlieb RA, Pandol SJ. Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis. Biochim Biophys Acta Mol Basis Dis. 2019 Nov 01; 1865(11):165530. PMID: 31398467.
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    6. Marek-Iannucci S, Thomas A, Hou J, Crupi A, Sin J, Taylor DJ, Czer LS, Esmailian F, Mentzer RM, Andres AM, Gottlieb RA. Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury. Sci Rep. 2019 Jul 10; 9(1):10001. PMID: 31292486.
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    7. Murray B, Peng H, Barbier-Torres L, Robinson AE, Li TWH, Fan W, Tomasi ML, Gottlieb RA, Van Eyk J, Lu Z, Martínez-Chantar ML, Liangpunsakul S, Skill NJ, Mato JM, Lu SC. Methionine Adenosyltransferase a1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression. Hepatology. 2019 Dec; 70(6):2018-2034. PMID: 31077594.
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    8. Onat UI, Yildirim AD, Tufanli Ö, Çimen I, Kocatürk B, Veli Z, Hamid SM, Shimada K, Chen S, Sin J, Shah PK, Gottlieb RA, Arditi M, Erbay E. Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis. J Am Coll Cardiol. 2019 03 19; 73(10):1149-1169. PMID: 30871699.
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    9. Matundan HH, Sin J, Rivas MN, Fishbein MC, Lehman TJ, Chen S, Gottlieb RA, Crother TR, Abe M, Arditi M. Myocardial fibrosis after adrenergic stimulation as a long-term sequela in a mouse model of Kawasaki disease vasculitis. JCI Insight. 2019 Feb 07; 4(3). PMID: 30728329.
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    10. Rajamani U, Gross AR, Ocampo C, Andres AM, Gottlieb RA, Sareen D. Retraction Note: Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives. Nat Commun. 2019 Feb 02; 10(1):645. PMID: 30712056.
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    11. Germano JF, Sawaged S, Saadaeijahromi H, Andres AM, Feuer R, Gottlieb RA, Sin J. Coxsackievirus B infection induces the extracellular release of miR-590-5p, a proviral microRNA. Virology. 2019 03; 529:169-176. PMID: 30711774.
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    12. Crupi AN, Nunnelee JS, Taylor DJ, Thomas A, Vit JP, Riera CE, Gottlieb RA, Goodridge HS. Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging. Aging (Albany NY). 2018 11 18; 10(11):3327-3352. PMID: 30449736.
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    13. Sobhani K, Nieves Castro DK, Fu Q, Gottlieb RA, Van Eyk JE, Noel Bairey Merz C. Sex differences in ischemic heart disease and heart failure biomarkers. Biol Sex Differ. 2018 09 17; 9(1):43. PMID: 30223899.
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    14. Stastna M, Thomas A, Germano J, Pourpirali S, Van Eyk JE, Gottlieb RA. Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion. J Vis Exp. 2018 08 29; (138). PMID: 30222143.
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    15. Mishra R, Haldar S, Placencio V, Madhav A, Rohena-Rivera K, Agarwal P, Duong F, Angara B, Tripathi M, Liu Z, Gottlieb RA, Wagner S, Posadas EM, Bhowmick NA. Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming. J Clin Invest. 2018 10 01; 128(10):4472-4484. PMID: 30047926.
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    16. Parker SJ, Stotland A, MacFarlane E, Wilson N, Orosco A, Venkatraman V, Madrid K, Gottlieb R, Dietz HC, Van Eyk JE. Proteomics reveals Rictor as a noncanonical TGF-ß signaling target during aneurysm progression in Marfan mice. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1112-H1126. PMID: 30004239.
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    17. Madhav A, Andres A, Duong F, Mishra R, Haldar S, Liu Z, Angara B, Gottlieb R, Zumsteg ZS, Bhowmick NA. Antagonizing CD105 enhances radiation sensitivity in prostate cancer. Oncogene. 2018 08; 37(32):4385-4397. PMID: 29717261.
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    18. Rajamani U, Gross AR, Hjelm BE, Sequeira A, Vawter MP, Tang J, Gangalapudi V, Wang Y, Andres AM, Gottlieb RA, Sareen D. Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses. Cell Stem Cell. 2018 05 03; 22(5):698-712.e9. PMID: 29681516.
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    19. Elliott EI, Miller AN, Banoth B, Iyer SS, Stotland A, Weiss JP, Gottlieb RA, Sutterwala FS, Cassel SL. Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming. J Immunol. 2018 05 01; 200(9):3047-3052. PMID: 29602772.
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    20. Aminzadeh MA, Rogers RG, Fournier M, Tobin RE, Guan X, Childers MK, Andres AM, Taylor DJ, Ibrahim A, Ding X, Torrente A, Goldhaber JM, Lewis M, Gottlieb RA, Victor RA, Marbán E. Exosome-Mediated Benefits of Cell Therapy in Mouse and Human Models of Duchenne Muscular Dystrophy. Stem Cell Reports. 2018 03 13; 10(3):942-955. PMID: 29478899.
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    21. Delange N, Lindsay S, Lemus H, Finlayson TL, Kelley ST, Gottlieb RA. Periodontal disease and its connection to systemic biomarkers of cardiovascular disease in young American Indian/Alaskan natives. J Periodontol. 2018 02; 89(2):219-227. PMID: 29520828.
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    22. Coronado M, Fajardo G, Nguyen K, Zhao M, Kooiker K, Jung G, Hu DQ, Reddy S, Sandoval E, Stotland A, Gottlieb RA, Bernstein D. Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand. Circ Res. 2018 01 19; 122(2):282-295. PMID: 29233845.
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    23. Sin J, McIntyre L, Stotland A, Feuer R, Gottlieb RA. Coxsackievirus B Escapes the Infected Cell in Ejected Mitophagosomes. J Virol. 2017 12 15; 91(24). PMID: 28978702.
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    24. Gottlieb RA. Delivering Instant Heat: Shocking the Heart. J Am Coll Cardiol. 2017 09 19; 70(12):1493-1495. PMID: 28911513.
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    25. Rajamani U, Gross AR, Ocampo C, Andres AM, Gottlieb RA, Sareen D. Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives. Nat Commun. 2017 08 09; 8(1):219. PMID: 28794470.
      View in: PubMed
    26. Campos JC, Queliconi BB, Bozi LHM, Bechara LRG, Dourado PMM, Andres AM, Jannig PR, Gomes KMS, Zambelli VO, Rocha-Resende C, Guatimosim S, Brum PC, Mochly-Rosen D, Gottlieb RA, Kowaltowski AJ, Ferreira JCB. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure. Autophagy. 2017 Aug 03; 13(8):1304-1317. PMID: 28598232.
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    27. Giricz Z, Varga ZV, Koncsos G, Nagy CT, Görbe A, Mentzer RM, Gottlieb RA, Ferdinandy P. Autophagosome formation is required for cardioprotection by chloramphenicol. Life Sci. 2017 Oct 01; 186:11-16. PMID: 28778689.
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    28. Lyra-Leite DM, Andres AM, Petersen AP, Ariyasinghe NR, Cho N, Lee JA, Gottlieb RA, McCain ML. Mitochondrial function in engineered cardiac tissues is regulated by extracellular matrix elasticity and tissue alignment. Am J Physiol Heart Circ Physiol. 2017 Oct 01; 313(4):H757-H767. PMID: 28733449.
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    29. Stastna M, Gottlieb RA, Van Eyk JE. Exploring ribosome composition and newly synthesized proteins through proteomics and potential biomedical applications. Expert Rev Proteomics. 2017 06; 14(6):529-543. PMID: 28532181.
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    30. Giricz Z, Koncsos G, Rajtík T, Varga ZV, Baranyai T, Csonka C, Szobi A, Adameová A, Gottlieb RA, Ferdinandy P. Hypercholesterolemia downregulates autophagy in the rat heart. Lipids Health Dis. 2017 Mar 23; 16(1):60. PMID: 28330474.
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    31. Taylor D, Gottlieb RA. Parkin-mediated mitophagy is downregulated in browning of white adipose tissue. Obesity (Silver Spring). 2017 04; 25(4):704-712. PMID: 28240819.
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    32. Andres AM, Tucker KC, Thomas A, Taylor DJ, Sengstock D, Jahania SM, Dabir R, Pourpirali S, Brown JA, Westbrook DG, Ballinger SW, Mentzer RM, Gottlieb RA. Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass. JCI Insight. 2017 02 23; 2(4):e89303. PMID: 28239650.
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    33. Queliconi BB, Kowaltowski AJ, Gottlieb RA. Bicarbonate Increases Ischemia-Reperfusion Damage by Inhibiting Mitophagy. PLoS One. 2016; 11(12):e0167678. PMID: 27973540.
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    34. Tumurkhuu G, Shimada K, Dagvadorj J, Crother TR, Zhang W, Luthringer D, Gottlieb RA, Chen S, Arditi M. Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis. Circ Res. 2016 Sep 02; 119(6):e76-90. PMID: 27384322.
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    35. Sin J, Puccini JM, Huang C, Konstandin MH, Gilbert PE, Sussman MA, Gottlieb RA, Feuer R. Correction: The Impact of Juvenile Coxsackievirus Infection on Cardiac Progenitor Cells and Postnatal Heart Development. PLoS Pathog. 2016 May; 12(5):e1005673. PMID: 27218802.
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    36. Andres AM, Kooren JA, Parker SJ, Tucker KC, Ravindran N, Ito BR, Huang C, Venkatraman V, Van Eyk JE, Gottlieb RA, Mentzer RM. Discordant signaling and autophagy response to fasting in hearts of obese mice: Implications for ischemia tolerance. Am J Physiol Heart Circ Physiol. 2016 07 01; 311(1):H219-28. PMID: 27199111.
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    37. Gottlieb RA, Bernstein D. Mitochondrial remodeling: Rearranging, recycling, and reprogramming. Cell Calcium. 2016 08; 60(2):88-101. PMID: 27130902.
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    38. Sin J, Andres AM, Taylor DJ, Weston T, Hiraumi Y, Stotland A, Kim BJ, Huang C, Doran KS, Gottlieb RA. Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts. Autophagy. 2016; 12(2):369-80. PMID: 26566717.
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    39. Gottlieb RA, Bernstein D. METABOLISM. Mitochondria shape cardiac metabolism. Science. 2015 Dec 04; 350(6265):1162-3. PMID: 26785456.
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    40. Stotland A, Gottlieb RA. a-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart. J Mol Cell Cardiol. 2016 Jan; 90:53-8. PMID: 26654779.
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    41. Xie Y, Collins WJ, Audeh MW, Shiao SL, Gottlieb RA, Goodman MT, Merz CN, Mehta PK. Breast Cancer Survivorship and Cardiovascular Disease: Emerging Approaches in Cardio-Oncology. Curr Treat Options Cardiovasc Med. 2015 Dec; 17(12):60. PMID: 26490280.
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    42. Gottlieb RA, Pourpirali S. Lost in translation: miRNAs and mRNAs in ischemic preconditioning and ischemia/reperfusion injury. J Mol Cell Cardiol. 2016 06; 95:70-7. PMID: 26582464.
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    43. Sin J, Mangale V, Thienphrapa W, Gottlieb RA, Feuer R. Recent progress in understanding coxsackievirus replication, dissemination, and pathogenesis. Virology. 2015 Oct; 484:288-304. PMID: 26142496.
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    44. Jeon CY, Pandol SJ, Wu B, Cook-Wiens G, Gottlieb RA, Bairey Merz CN, Goodman MT. Correction: The Association of Statin Use after Cancer Diagnosis with Survival in Pancreatic Cancer Patients: A SEER-Medicare Analysis. PLoS One. 2015; 10(5):e0128730. PMID: 26017388.
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    45. Jeon CY, Pandol SJ, Wu B, Cook-Wiens G, Gottlieb RA, Merz CN, Merz NB, Goodman MT. The association of statin use after cancer diagnosis with survival in pancreatic cancer patients: a SEER-medicare analysis. PLoS One. 2015; 10(4):e0121783. PMID: 25830309.
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    46. Delbridge LM, Mellor KM, Taylor DJ, Gottlieb RA. Myocardial autophagic energy stress responses--macroautophagy, mitophagy, and glycophagy. Am J Physiol Heart Circ Physiol. 2015 May 15; 308(10):H1194-204. PMID: 25747748.
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    47. Gottlieb RA, Andres AM, Sin J, Taylor DP. Untangling autophagy measurements: all fluxed up. Circ Res. 2015 Jan 30; 116(3):504-14. PMID: 25634973.
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    48. Stotland A, Gottlieb RA. Mitochondrial quality control: Easy come, easy go. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt B):2802-11. PMID: 25596427.
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    49. Gurney MA, Huang C, Ramil JM, Ravindran N, Andres AM, Sin J, Linton PJ, Gottlieb RA. Measuring cardiac autophagic flux in vitro and in vivo. Methods Mol Biol. 2015; 1219:187-97. PMID: 25308270.
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    50. Linton PJ, Gurney M, Sengstock D, Mentzer RM, Gottlieb RA. This old heart: Cardiac aging and autophagy. J Mol Cell Cardiol. 2015 Jun; 83:44-54. PMID: 25543002.
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    51. Gottlieb RA, Stotland A. MitoTimer: a novel protein for monitoring mitochondrial turnover in the heart. J Mol Med (Berl). 2015 Mar; 93(3):271-8. PMID: 25479961.
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    52. Andres AM, Stotland A, Queliconi BB, Gottlieb RA. A time to reap, a time to sow: mitophagy and biogenesis in cardiac pathophysiology. J Mol Cell Cardiol. 2015 Jan; 78:62-72. PMID: 25444712.
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    53. Sin J, Puccini JM, Huang C, Konstandin MH, Gilbert PE, Sussman MA, Gottlieb RA, Feuer R. The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. PLoS Pathog. 2014 Jul; 10(7):e1004249. PMID: 25079373.
      View in: PubMed
    54. Robinson SM, Tsueng G, Sin J, Mangale V, Rahawi S, McIntyre LL, Williams W, Kha N, Cruz C, Hancock BM, Nguyen DP, Sayen MR, Hilton BJ, Doran KS, Segall AM, Wolkowicz R, Cornell CT, Whitton JL, Gottlieb RA, Feuer R. Coxsackievirus B exits the host cell in shed microvesicles displaying autophagosomal markers. PLoS Pathog. 2014 Apr; 10(4):e1004045. PMID: 24722773.
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    55. Schwarzberg K, Le R, Bharti B, Lindsay S, Casaburi G, Salvatore F, Saber MH, Alonaizan F, Slots J, Gottlieb RA, Caporaso JG, Kelley ST. The personal human oral microbiome obscures the effects of treatment on periodontal disease. PLoS One. 2014; 9(1):e86708. PMID: 24489772.
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    56. Trudeau KM, Gottlieb RA, Shirihai OS. Measurement of mitochondrial turnover and life cycle using MitoTimer. Methods Enzymol. 2014; 547:21-38. PMID: 25416350.
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    57. Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel ED. Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest. 2013 Dec; 123(12):5319-33. PMID: 24177427.
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    58. Hernandez G, Thornton C, Stotland A, Lui D, Sin J, Ramil J, Magee N, Andres A, Quarato G, Carreira RS, Sayen MR, Wolkowicz R, Gottlieb RA. MitoTimer: a novel tool for monitoring mitochondrial turnover. Autophagy. 2013 Nov 01; 9(11):1852-61. PMID: 24128932.
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    59. Ferree AW, Trudeau K, Zik E, Benador IY, Twig G, Gottlieb RA, Shirihai OS. MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age. Autophagy. 2013 Nov 01; 9(11):1887-96. PMID: 24149000.
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    60. Andres AM, Hernandez G, Lee P, Huang C, Ratliff EP, Sin J, Thornton CA, Damasco MV, Gottlieb RA. Mitophagy is required for acute cardioprotection by simvastatin. Antioxid Redox Signal. 2014 Nov 10; 21(14):1960-73. PMID: 23901824.
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    61. Gottlieb RA, Mentzer RM. Autophagy: an affair of the heart. Heart Fail Rev. 2013 Sep; 18(5):575-84. PMID: 23188163.
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    62. Vanrell MC, Cueto JA, Barclay JJ, Carrillo C, Colombo MI, Gottlieb RA, Romano PS. Polyamine depletion inhibits the autophagic response modulating Trypanosoma cruzi infectivity. Autophagy. 2013 Jul; 9(7):1080-93. PMID: 23697944.
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    63. Jahania SM, Sengstock D, Vaitkevicius P, Andres A, Ito BR, Gottlieb RA, Mentzer RM. Activation of the homeostatic intracellular repair response during cardiac surgery. J Am Coll Surg. 2013 Apr; 216(4):719-26; discussion 726-9. PMID: 23415552.
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    64. Giricz Z, Mentzer RM, Gottlieb RA. Autophagy, myocardial protection, and the metabolic syndrome. J Cardiovasc Pharmacol. 2012 Aug; 60(2):125-32. PMID: 22472909.
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    65. Gottlieb RA, Linton PJ. Indigestible mitochondria cause heartburn. Cell Res. 2012 Nov; 22(11):1518-20. PMID: 22710797.
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    66. Gottlieb RA, Mentzer RM, Linton PJ. Impaired mitophagy at the heart of injury. Autophagy. 2011 Dec; 7(12):1573-4. PMID: 22082870.
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    67. Gottlieb RA. Cell death pathways in acute ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther. 2011 Sep-Dec; 16(3-4):233-8. PMID: 21821521.
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    68. Huang C, Andres AM, Ratliff EP, Hernandez G, Lee P, Gottlieb RA. Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS One. 2011; 6(6):e20975. PMID: 21687634.
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    69. Gottlieb RA, Mentzer RM. Cardioprotection through autophagy: ready for clinical trial? Autophagy. 2011 Apr; 7(4):434-5. PMID: 21187717.
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    70. Przyklenk K, Undyala VV, Wider J, Sala-Mercado JA, Gottlieb RA, Mentzer RM. Acute induction of autophagy as a novel strategy for cardioprotection: getting to the heart of the matter. Autophagy. 2011 Apr; 7(4):432-3. PMID: 21187719.
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    71. Perry CN, Huang C, Liu W, Magee N, Carreira RS, Gottlieb RA. Xenotransplantation of mitochondrial electron transfer enzyme, Ndi1, in myocardial reperfusion injury. PLoS One. 2011 Feb 14; 6(2):e16288. PMID: 21339825.
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    72. Gottlieb RA, Gustafsson AB. Mitochondrial turnover in the heart. Biochim Biophys Acta. 2011 Jul; 1813(7):1295-301. PMID: 21147177.
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    73. Sala-Mercado JA, Wider J, Undyala VV, Jahania S, Yoo W, Mentzer RM, Gottlieb RA, Przyklenk K. Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury. Circulation. 2010 Sep 14; 122(11 Suppl):S179-84. PMID: 20837911.
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    74. Dong Y, Undyala VV, Gottlieb RA, Mentzer RM, Przyklenk K. Autophagy: definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury. J Cardiovasc Pharmacol Ther. 2010 Sep; 15(3):220-30. PMID: 20595626.
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    75. Carreira RS, Lee Y, Ghochani M, Gustafsson ÅB, Gottlieb RA. Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells. Autophagy. 2010 May; 6(4):462-72. PMID: 20364102.
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    76. Huang C, Yitzhaki S, Perry CN, Liu W, Giricz Z, Mentzer RM, Gottlieb RA. Autophagy induced by ischemic preconditioning is essential for cardioprotection. J Cardiovasc Transl Res. 2010 Aug; 3(4):365-73. PMID: 20559777.
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    77. Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res. 2010 Apr 16; 106(7):1265-74. PMID: 20203306.
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    78. Gottlieb RA, Mentzer RM. Autophagy during cardiac stress: joys and frustrations of autophagy. Annu Rev Physiol. 2010; 72:45-59. PMID: 20148666.
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    79. Quinsay MN, Lee Y, Rikka S, Sayen MR, Molkentin JD, Gottlieb RA, Gustafsson AB. Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism. J Mol Cell Cardiol. 2010 Jun; 48(6):1146-56. PMID: 20025887.
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    80. Huang C, Liu W, Perry CN, Yitzhaki S, Lee Y, Yuan H, Tsukada YT, Hamacher-Brady A, Mentzer RM, Gottlieb RA. Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole. Am J Physiol Heart Circ Physiol. 2010 Feb; 298(2):H570-9. PMID: 20008275.
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    81. Whittaker R, Glassy MS, Gude N, Sussman MA, Gottlieb RA, Glembotski CC. Kinetics of the translocation and phosphorylation of alphaB-crystallin in mouse heart mitochondria during ex vivo ischemia. Am J Physiol Heart Circ Physiol. 2009 May; 296(5):H1633-42. PMID: 19252088.
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    82. Gottlieb RA, Finley KD, Mentzer RM. Cardioprotection requires taking out the trash. Basic Res Cardiol. 2009 Mar; 104(2):169-80. PMID: 19242643.
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    83. Yitzhaki S, Huang C, Liu W, Lee Y, Gustafsson AB, Mentzer RM, Gottlieb RA. Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA. Basic Res Cardiol. 2009 Mar; 104(2):157-67. PMID: 19242639.
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    84. Gustafsson AB, Gottlieb RA. Autophagy in ischemic heart disease. Circ Res. 2009 Jan 30; 104(2):150-8. PMID: 19179668.
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    85. Perry CN, Kyoi S, Hariharan N, Takagi H, Sadoshima J, Gottlieb RA. Novel methods for measuring cardiac autophagy in vivo. Methods Enzymol. 2009; 453:325-42. PMID: 19216914.
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    86. Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, Glembotski CC, Gottlieb RA. LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. Am J Physiol Heart Circ Physiol. 2009 Feb; 296(2):H470-9. PMID: 19098111.
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    100. Gustafsson AB, Gottlieb RA. Bcl-2 family members and apoptosis, taken to heart. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C45-51. PMID: 16943242.
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    127. He H, Li HL, Lin A, Gottlieb RA. Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia. Cell Death Differ. 1999 Oct; 6(10):987-91. PMID: 10556976.
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    129. Adachi S, Gottlieb RA, Babior BM. Lack of release of cytochrome C from mitochondria into cytosol early in the course of Fas-mediated apoptosis of Jurkat cells. J Biol Chem. 1998 Jul 31; 273(31):19892-4. PMID: 9677426.
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    133. Gottlieb RA, Dosanjh A. Mutant cystic fibrosis transmembrane conductance regulator inhibits acidification and apoptosis in C127 cells: possible relevance to cystic fibrosis. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3587-91. PMID: 8622979.
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