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Samson A Chow

Title(s)Professor, Molecular and Medical Pharmacology
SchoolMedicine
Address760 Westwood Plaza 23-120
Los Angeles CA 90024
Phone3108259600
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    Collapse Research 
    Collapse Research Activities and Funding
    Characterizing the binding between HIV-1 integrase and capsid and the role of the interaction in modulating the uncoating process
    NIH/NIAID R21AI118540Apr 8, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Role of HIV-1 IN during reverse transcription and uncoating
    NIH/NIGMS R01GM101416Sep 1, 2011 - Aug 31, 2015
    Role: Principal Investigator
    Binding Between HIV-1 RT and IN and Its Functional Signification
    NIH/NIAID R21AI077386Jun 10, 2008 - May 31, 2010
    Role: Principal Investigator
    PET DETECTION AND INTEGRASE INHIBITORS OF FIV INFECTION
    NIH/NIAID R01AI044680Jun 1, 1999 - May 31, 2003
    Role: Principal Investigator
    Molecular Mechanisms of HIV-1 DNA Integration
    NIH/NCI R01CA068859Sep 1, 1995 - Mar 31, 2009
    Role: Principal Investigator
    TOPOGRAPHY OF RECA PROTEIN-PROMOTED HOMOLOGOUS PAIRING
    NIH/NIGMS F32GM010422Feb 1, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication. J Virol. 2015 Dec; 89(23):12058-69. Tekeste SS, Wilkinson TA, Weiner EM, Xu X, Miller JT, Le Grice SF, Clubb RT, Chow SA. PMID: 26401032.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    2. Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study. Cell Stem Cell. 2014 Apr 03; 14(4):473-85. Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS. PMID: 24702996.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    3. Analysis of single-nucleotide polymorphisms in patient-derived retrovirus integration sites reveals contamination from cell lines acutely infected by xenotropic murine leukemia virus-related virus. J Virol. 2011 Dec; 85(23):12830-4. Rusmevichientong A, Das Gupta J, Elias PS, Silverman RH, Chow SA. PMID: 21937660.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    4. Efficient identification of human immunodeficiency virus type 1 mutants resistant to a protease inhibitor by using a random mutant library. Antimicrob Agents Chemother. 2011 Nov; 55(11):5090-8. Kim S, Kim YC, Qi H, Su K, Morrison SL, Chow SA. PMID: 21876045.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. A new functional role of HIV-1 integrase during uncoating of the viral core. Immunol Res. 2010 Dec; 48(1-3):14-26. Briones MS, Chow SA. PMID: 20721640.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease. Immunol Res. 2010 Dec; 48(1-3):27-39. Rusmevichientong A, Chow SA. PMID: 20717743.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones. J Virol. 2010 Nov; 84(22):11771-80. Kim S, Kim N, Presson AP, An DS, Mao SH, Bonifacino AC, Donahue RE, Chow SA, Chen IS. PMID: 20844053.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    8. Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus. PLoS One. 2010 Apr 20; 5(4):e10255. Kim S, Rusmevichientong A, Dong B, Remenyi R, Silverman RH, Chow SA. PMID: 20421928.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    9. Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core. J Virol. 2010 May; 84(10):5181-90. Briones MS, Dobard CW, Chow SA. PMID: 20219923.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    10. The nuclear pore complex: a new dynamic in HIV-1 replication. Nucleus. 2010 Jan-Feb; 1(1):18-22. Woodward CL, Chow SA. PMID: 21327100.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells. J Virol. 2009 Jun; 83(12):6222-33. Vatakis DN, Kim S, Kim N, Chow SA, Zack JA. PMID: 19369341.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    12. Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1. J Virol. 2009 Jul; 83(13):6522-33. Woodward CL, Prakobwanakit S, Mosessian S, Chow SA. PMID: 19369352.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    13. Site-specific integration of retroviral DNA in human cells using fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc-finger protein E2C. Methods. 2009 Apr; 47(4):269-76. Su K, Wang D, Ye J, Kim YC, Chow SA. PMID: 19186211.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. Identifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase. J Biol Chem. 2009 Mar 20; 284(12):7931-9. Wilkinson TA, Januszyk K, Phillips ML, Tekeste SS, Zhang M, Miller JT, Le Grice SF, Clubb RT, Chow SA. PMID: 19150986.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    15. Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer. J Virol. 2008 Oct; 82(20):9964-77. Kim S, Kim N, Dong B, Boren D, Lee SA, Das Gupta J, Gaughan C, Klein EA, Lee C, Silverman RH, Chow SA. PMID: 18684813.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    16. Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcription. J Virol. 2007 Sep; 81(18):10037-46. Dobard CW, Briones MS, Chow SA. PMID: 17626089.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    17. An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1655-60. Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH. PMID: 17234809.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    18. Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells. J Virol. 2007 Apr; 81(7):3574-82. Vatakis DN, Bristol G, Wilkinson TA, Chow SA, Zack JA. PMID: 17229711.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    19. A high-throughput method for cloning and sequencing human immunodeficiency virus type 1 integration sites. J Virol. 2006 Nov; 80(22):11313-21. Kim S, Kim Y, Liang T, Sinsheimer JS, Chow SA. PMID: 16971446.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    20. Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cells. J Virol. 2006 Feb; 80(4):1939-48. Tan W, Dong Z, Wilkinson TA, Barbas CF, Chow SA. PMID: 16439549.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    21. Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development. Curr HIV Res. 2005 Oct; 3(4):377-92. Brooks DG, Cohen MD, Jamieson BD, Poon B, Kitchen SG, Chow SA, Chen IS, Zack JA, Koka PS. PMID: 16250884.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase. J Virol. 2004 May; 78(10):5045-55. Zhu K, Dobard C, Chow SA. PMID: 15113886.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    23. Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites. J Virol. 2004 Feb; 78(3):1301-13. Tan W, Zhu K, Segal DJ, Barbas CF, Chow SA. PMID: 14722285.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    24. Subcellular localization of feline immunodeficiency virus integrase and mapping of its karyophilic determinant. J Virol. 2003 Apr; 77(8):4516-27. Woodward CL, Wang Y, Dixon WJ, Htun H, Chow SA. PMID: 12663758.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    25. Correct integration mediated by integrase-LexA fusion proteins incorporated into HIV-1. Mol Ther. 2002 Apr; 5(4):360-70. Holmes-Son ML, Chow SA. PMID: 11945062.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
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