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Chow, Samson A

Title(s)Professor, Molecular And Medical Pharmacology
Phone3108259600
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    Collapse Research 
    Collapse Research Activities and Funding
    Characterizing the binding between HIV-1 integrase and capsid and the role of the interaction in modulating the uncoating process
    NIH/NIAID R21AI118540Apr 8, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Role of HIV-1 IN during reverse transcription and uncoating
    NIH/NIGMS R01GM101416Sep 1, 2011 - Aug 31, 2015
    Role: Principal Investigator
    Binding Between HIV-1 RT and IN and Its Functional Signification
    NIH/NIAID R21AI077386Jun 10, 2008 - May 31, 2010
    Role: Principal Investigator
    PET DETECTION AND INTEGRASE INHIBITORS OF FIV INFECTION
    NIH/NIAID R01AI044680Jun 1, 1999 - May 31, 2003
    Role: Principal Investigator
    Molecular Mechanisms of HIV-1 DNA Integration
    NIH/NCI R01CA068859Sep 1, 1995 - Mar 31, 2009
    Role: Principal Investigator
    TOPOGRAPHY OF RECA PROTEIN-PROMOTED HOMOLOGOUS PAIRING
    NIH/NIGMS F32GM010422Feb 1, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tekeste SS, Wilkinson TA, Weiner EM, Xu X, Miller JT, Le Grice SF, Clubb RT, Chow SA. Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication. J Virol. 2015 Dec; 89(23):12058-69. PMID: 26401032.
      View in: PubMed
    2. Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS. Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study. Cell Stem Cell. 2014 Apr 03; 14(4):473-85. PMID: 24702996.
      View in: PubMed
    3. Rusmevichientong A, Das Gupta J, Elias PS, Silverman RH, Chow SA. Analysis of single-nucleotide polymorphisms in patient-derived retrovirus integration sites reveals contamination from cell lines acutely infected by xenotropic murine leukemia virus-related virus. J Virol. 2011 Dec; 85(23):12830-4. PMID: 21937660.
      View in: PubMed
    4. Kim S, Kim YC, Qi H, Su K, Morrison SL, Chow SA. Efficient identification of human immunodeficiency virus type 1 mutants resistant to a protease inhibitor by using a random mutant library. Antimicrob Agents Chemother. 2011 Nov; 55(11):5090-8. PMID: 21876045.
      View in: PubMed
    5. Briones MS, Chow SA. A new functional role of HIV-1 integrase during uncoating of the viral core. Immunol Res. 2010 Dec; 48(1-3):14-26. PMID: 20721640.
      View in: PubMed
    6. Rusmevichientong A, Chow SA. Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease. Immunol Res. 2010 Dec; 48(1-3):27-39. PMID: 20717743.
      View in: PubMed
    7. Kim S, Kim N, Presson AP, An DS, Mao SH, Bonifacino AC, Donahue RE, Chow SA, Chen IS. High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones. J Virol. 2010 Nov; 84(22):11771-80. PMID: 20844053.
      View in: PubMed
    8. Kim S, Rusmevichientong A, Dong B, Remenyi R, Silverman RH, Chow SA. Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus. PLoS One. 2010 Apr 20; 5(4):e10255. PMID: 20421928.
      View in: PubMed
    9. Briones MS, Dobard CW, Chow SA. Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core. J Virol. 2010 May; 84(10):5181-90. PMID: 20219923.
      View in: PubMed
    10. Woodward CL, Chow SA. The nuclear pore complex: a new dynamic in HIV-1 replication. Nucleus. 2010 Jan-Feb; 1(1):18-22. PMID: 21327100.
      View in: PubMed
    11. Vatakis DN, Kim S, Kim N, Chow SA, Zack JA. Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells. J Virol. 2009 Jun; 83(12):6222-33. PMID: 19369341.
      View in: PubMed
    12. Woodward CL, Prakobwanakit S, Mosessian S, Chow SA. Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1. J Virol. 2009 Jul; 83(13):6522-33. PMID: 19369352.
      View in: PubMed
    13. Su K, Wang D, Ye J, Kim YC, Chow SA. Site-specific integration of retroviral DNA in human cells using fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc-finger protein E2C. Methods. 2009 Apr; 47(4):269-76. PMID: 19186211.
      View in: PubMed
    14. Wilkinson TA, Januszyk K, Phillips ML, Tekeste SS, Zhang M, Miller JT, Le Grice SF, Clubb RT, Chow SA. Identifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase. J Biol Chem. 2009 Mar 20; 284(12):7931-9. PMID: 19150986.
      View in: PubMed
    15. Kim S, Kim N, Dong B, Boren D, Lee SA, Das Gupta J, Gaughan C, Klein EA, Lee C, Silverman RH, Chow SA. Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer. J Virol. 2008 Oct; 82(20):9964-77. PMID: 18684813.
      View in: PubMed
    16. Dobard CW, Briones MS, Chow SA. Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcription. J Virol. 2007 Sep; 81(18):10037-46. PMID: 17626089.
      View in: PubMed
    17. Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH. An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1655-60. PMID: 17234809.
      View in: PubMed
    18. Vatakis DN, Bristol G, Wilkinson TA, Chow SA, Zack JA. Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells. J Virol. 2007 Apr; 81(7):3574-82. PMID: 17229711.
      View in: PubMed
    19. Kim S, Kim Y, Liang T, Sinsheimer JS, Chow SA. A high-throughput method for cloning and sequencing human immunodeficiency virus type 1 integration sites. J Virol. 2006 Nov; 80(22):11313-21. PMID: 16971446.
      View in: PubMed
    20. Tan W, Dong Z, Wilkinson TA, Barbas CF, Chow SA. Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cells. J Virol. 2006 Feb; 80(4):1939-48. PMID: 16439549.
      View in: PubMed
    21. Brooks DG, Cohen MD, Jamieson BD, Poon B, Kitchen SG, Chow SA, Chen IS, Zack JA, Koka PS. Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development. Curr HIV Res. 2005 Oct; 3(4):377-92. PMID: 16250884.
      View in: PubMed
    22. Zhu K, Dobard C, Chow SA. Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase. J Virol. 2004 May; 78(10):5045-55. PMID: 15113886.
      View in: PubMed
    23. Tan W, Zhu K, Segal DJ, Barbas CF, Chow SA. Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites. J Virol. 2004 Feb; 78(3):1301-13. PMID: 14722285.
      View in: PubMed
    24. Woodward CL, Wang Y, Dixon WJ, Htun H, Chow SA. Subcellular localization of feline immunodeficiency virus integrase and mapping of its karyophilic determinant. J Virol. 2003 Apr; 77(8):4516-27. PMID: 12663758.
      View in: PubMed
    25. Holmes-Son ML, Chow SA. Correct integration mediated by integrase-LexA fusion proteins incorporated into HIV-1. Mol Ther. 2002 Apr; 5(4):360-70. PMID: 11945062.
      View in: PubMed