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Hu Shen

Title(s)Member, CTSI
SchoolCTSI
Phone(310) 206-8834
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    Other Positions
    Title(s)Associate Professor, Dentistry

    Title(s)Member, JCCC Signal Transduction and Therapeutics Program Area


    Collapse Research 
    Collapse Research Activities and Funding
    Serum Proteome Analysis of Oral Cancer Metastasis
    NIH/NCI R21CA122806May 7, 2007 - Apr 30, 2010
    Role: Principal Investigator
    Quantitative Salivary Proteomics for Human Oral Cancer
    NIH/NIDCR R03DE017144Apr 10, 2007 - May 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jin Z, Zhao X, Cui L, Xu X, Zhao Y, Younai F, Messadi D, Hu S. UBE2C promotes the progression of head and neck squamous cell carcinoma. Biochem Biophys Res Commun. 2019 Dec 20. PMID: 31870550.
      View in: PubMed
    2. Ji EH, Elzakra N, Chen W, Cui L, Lee ES, Sun B, Messadi D, Xia T, Zhu Y, Hu S. E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes. J Cancer. 2019; 10(27):6915-6924. PMID: 31839827.
      View in: PubMed
    3. Cui L, Wang X, Sun B, Xia T, Hu S. Predictive Metabolomic Signatures for Safety Assessment of Metal Oxide Nanoparticles. ACS Nano. 2019 Nov 11. PMID: 31682760.
      View in: PubMed
    4. Huang J, Ji EH, Zhao X, Cui L, Misuno K, Guo M, Huang Z, Chen X, Hu S. Sox11 promotes head and neck cancer progression via the regulation of SDCCAG8. J Exp Clin Cancer Res. 2019 Mar 29; 38(1):138. PMID: 30922366.
      View in: PubMed
    5. Cui L, Zhao X, Hu S. Determination of Autoantibodies to Salivary Gland Antigens. Methods Mol Biol. 2019; 1901:103-112. PMID: 30539572.
      View in: PubMed
    6. Cui L, Liu J, Yan X, Hu S. Identification of Metabolite Biomarkers for Gout Using Capillary Ion Chromatography with Mass Spectrometry. Anal Chem. 2017 11 07; 89(21):11737-11743. PMID: 28972752.
      View in: PubMed
    7. Elzakra N, Cui L, Liu T, Li H, Huang J, Hu S. Mass Spectrometric Analysis of SOX11-Binding Proteins in Head and Neck Cancer Cells Demonstrates the Interaction of SOX11 and HSP90a. J Proteome Res. 2017 11 03; 16(11):3961-3968. PMID: 28915052.
      View in: PubMed
    8. Guo M, Shen J, Kwak JH, Choi B, Lee M, Hu S, Zhang X, Ting K, Soo CB, Chiu RH. Correction for Guo et al., "Novel Role for Cyclophilin A in Regulation of Chondrogenic Commitment and Endochondral Ossification". Mol Cell Biol. 2017 09 15; 37(18). PMID: 28847975.
      View in: PubMed
    9. Cui L, Elzakra N, Xu S, Xiao GG, Yang Y, Hu S. Investigation of three potential autoantibodies in Sjogren's syndrome and associated MALT lymphoma. Oncotarget. 2017 May 02; 8(18):30039-30049. PMID: 28404907.
      View in: PubMed
    10. Ji EH, Cui L, Yuan X, Cheng S, Messadi D, Yan X, Hu S. Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition. J Cancer. 2017; 8(2):298-304. PMID: 28243334.
      View in: PubMed
    11. Ji EH, Diep C, Liu T, Li H, Merrill R, Messadi D, Hu S. Potential protein biomarkers for burning mouth syndrome discovered by quantitative proteomics. Mol Pain. 2017 01; 13:1744806916686796. PMID: 28326926.
      View in: PubMed
    12. Cui L, Cheng S, Liu X, Messadi D, Yang Y, Hu S. Syntenin-1 is a promoter and prognostic marker of head and neck squamous cell carcinoma invasion and metastasis. Oncotarget. 2016 Dec 13; 7(50):82634-82647. PMID: 27811365.
      View in: PubMed
    13. Liu Y, Cui L, Huang J, Ji EH, Chen W, Messadi D, Hu S. SOX4 Promotes Progression in OLP-Associated Squamous Cell Carcinoma. J Cancer. 2016; 7(11):1534-40. PMID: 27471569.
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    14. Feng S, Rabii R, Liang G, Song C, Chen W, Guo M, Wei X, Messadi D, Hu S. The Expression Levels of XLF and Mutant P53 Are Inversely Correlated in Head and Neck Cancer Cells. J Cancer. 2016; 7(11):1374-82. PMID: 27471552.
      View in: PubMed
    15. Ji EH, Sun B, Zhao T, Shu S, Chang CH, Messadi D, Xia T, Zhu Y, Hu S. Characterization of Electronic Cigarette Aerosol and Its Induction of Oxidative Stress Response in Oral Keratinocytes. PLoS One. 2016; 11(5):e0154447. PMID: 27223106.
      View in: PubMed
    16. Chai YD, Zhang L, Yang Y, Su T, Charugundla P, Ai J, Messadi D, Wong DT, Hu S. Discovery of potential serum protein biomarkers for lymph node metastasis in oral cancer. Head Neck. 2016 Jan; 38(1):118-25. PMID: 25223295.
      View in: PubMed
    17. Hu S, Wang J, Ji EH, Christison T, Lopez L, Huang Y. Targeted Metabolomic Analysis of Head and Neck Cancer Cells Using High Performance Ion Chromatography Coupled with a Q Exactive HF Mass Spectrometer. Anal Chem. 2015 Jun 16; 87(12):6371-9. PMID: 25973679.
      View in: PubMed
    18. Guo M, Shen J, Kwak JH, Choi B, Lee M, Hu S, Zhang X, Ting K, Soo CB, Chiu RH. Novel role for cyclophilin A in regulation of chondrogenic commitment and endochondral ossification. Mol Cell Biol. 2015 Jun; 35(12):2119-30. PMID: 25870110.
      View in: PubMed
    19. Ho JW, Jung YL, Liu T, Alver BH, Lee S, Ikegami K, Sohn KA, Minoda A, Tolstorukov MY, Appert A, Parker SC, Gu T, Kundaje A, Riddle NC, Bishop E, Egelhofer TA, Hu SS, Alekseyenko AA, Rechtsteiner A, Asker D, Belsky JA, Bowman SK, Chen QB, Chen RA, Day DS, Dong Y, Dose AC, Duan X, Epstein CB, Ercan S, Feingold EA, Ferrari F, Garrigues JM, Gehlenborg N, Good PJ, Haseley P, He D, Herrmann M, Hoffman MM, Jeffers TE, Kharchenko PV, Kolasinska-Zwierz P, Kotwaliwale CV, Kumar N, Langley SA, Larschan EN, Latorre I, Libbrecht MW, Lin X, Park R, Pazin MJ, Pham HN, Plachetka A, Qin B, Schwartz YB, Shoresh N, Stempor P, Vielle A, Wang C, Whittle CM, Xue H, Kingston RE, Kim JH, Bernstein BE, Dernburg AF, Pirrotta V, Kuroda MI, Noble WS, Tullius TD, Kellis M, MacAlpine DM, Strome S, Elgin SC, Liu XS, Lieb JD, Ahringer J, Karpen GH, Park PJ. Comparative analysis of metazoan chromatin organization. Nature. 2014 Aug 28; 512(7515):449-52. PMID: 25164756.
      View in: PubMed
    20. Arellano-Garcia ME, Misuno K, Tran SD, Hu S. Interferon-? induces immunoproteasomes and the presentation of MHC I-associated peptides on human salivary gland cells. PLoS One. 2014; 9(8):e102878. PMID: 25102056.
      View in: PubMed
    21. Misuno K, Tran SD, Khalili S, Huang J, Liu Y, Hu S. Quantitative analysis of protein and gene expression in salivary glands of Sjogren's-like disease NOD mice treated by bone marrow soup. PLoS One. 2014; 9(1):e87158. PMID: 24489858.
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    22. He HH, Meyer CA, Hu SS, Chen MW, Zang C, Liu Y, Rao PK, Fei T, Xu H, Long H, Liu XS, Brown M. Refined DNase-seq protocol and data analysis reveals intrinsic bias in transcription factor footprint identification. Nat Methods. 2014 Jan; 11(1):73-78. PMID: 24317252.
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    23. Elashoff D, Zhou H, Reiss J, Wang J, Xiao H, Henson B, Hu S, Arellano M, Sinha U, Le A, Messadi D, Wang M, Nabili V, Lingen M, Morris D, Randolph T, Feng Z, Akin D, Kastratovic DA, Chia D, Abemayor E, Wong DT. Prevalidation of salivary biomarkers for oral cancer detection. Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):664-72. PMID: 22301830.
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    24. Hu S, Vissink A, Arellano M, Roozendaal C, Zhou H, Kallenberg CG, Wong DT. Identification of autoantibody biomarkers for primary Sjögren's syndrome using protein microarrays. Proteomics. 2011 Apr; 11(8):1499-507. PMID: 21413148.
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    25. Chang WH, Hu SP, Huang YF, Yeh TS, Liu JF. Effect of purple sweet potato leaves consumption on exercise-induced oxidative stress and IL-6 and HSP72 levels. J Appl Physiol (1985). 2010 Dec; 109(6):1710-5. PMID: 20864555.
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    26. Liu X, Zhang M, Go VL, Hu S. Membrane proteomic analysis of pancreatic cancer cells. J Biomed Sci. 2010 Sep 13; 17:74. PMID: 20831833.
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    27. Arellano-Garcia ME, Li R, Liu X, Xie Y, Yan X, Loo JA, Hu S. Identification of tetranectin as a potential biomarker for metastatic oral cancer. Int J Mol Sci. 2010 Sep 02; 11(9):3106-21. PMID: 20957082.
      View in: PubMed
    28. Liu Y, Messadi DV, Wu H, Hu S. Oral lichen planus is a unique disease model for studying chronic inflammation and oral cancer. Med Hypotheses. 2010 Dec; 75(6):492-4. PMID: 20674185.
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    29. Hu S, Gao K, Pollard R, Arellano-Garcia M, Zhou H, Zhang L, Elashoff D, Kallenberg CG, Vissink A, Wong DT. Preclinical validation of salivary biomarkers for primary Sjögren's syndrome. Arthritis Care Res (Hoboken). 2010 Nov; 62(11):1633-8. PMID: 20617533.
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    30. Hu S, Jiang J, Wong DT. Proteomic analysis of saliva: 2D gel electrophoresis, LC-MS/MS, and Western blotting. Methods Mol Biol. 2010; 666:31-41. PMID: 20717776.
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    31. Gao K, Zhou H, Zhang L, Lee JW, Zhou Q, Hu S, Wolinsky LE, Farrell J, Eibl G, Wong DT. Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer. PLoS One. 2009 Jun 11; 4(6):e5875. PMID: 19517020.
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    32. Wei F, Patel P, Liao W, Chaudhry K, Zhang L, Arellano-Garcia M, Hu S, Elashoff D, Zhou H, Shukla S, Shah F, Ho CM, Wong DT. Electrochemical sensor for multiplex biomarkers detection. Clin Cancer Res. 2009 Jul 01; 15(13):4446-52. PMID: 19509137.
      View in: PubMed
    33. Arellano M, Jiang J, Zhou X, Zhang L, Ye H, Wong DT, Hu S. Current advances in identification of cancer biomarkers in saliva. Front Biosci (Schol Ed). 2009 Jun 01; 1:296-303. PMID: 19482703.
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    34. Hu S, Wong DT. Lectin microarray. Proteomics Clin Appl. 2009 Feb; 3(2):148-54. PMID: 21132067.
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    35. Hu S, Zhou M, Jiang J, Wang J, Elashoff D, Gorr S, Michie SA, Spijkervet FK, Bootsma H, Kallenberg CG, Vissink A, Horvath S, Wong DT. Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands. Arthritis Rheum. 2009 Jan; 60(1):81-92. PMID: 19116902.
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    36. Yan W, Apweiler R, Balgley BM, Boontheung P, Bundy JL, Cargile BJ, Cole S, Fang X, Gonzalez-Begne M, Griffin TJ, Hagen F, Hu S, Wolinsky LE, Lee CS, Malamud D, Melvin JE, Menon R, Mueller M, Qiao R, Rhodus NL, Sevinsky JR, States D, Stephenson JL, Than S, Yates JR, Yu W, Xie H, Xie Y, Omenn GS, Loo JA, Wong DT. Systematic comparison of the human saliva and plasma proteomes. Proteomics Clin Appl. 2009 Jan 01; 3(1):116-134. PMID: 19898684.
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    37. Jiang J, Park NJ, Hu S, Wong DT. A universal pre-analytic solution for concurrent stabilization of salivary proteins, RNA and DNA at ambient temperature. Arch Oral Biol. 2009 Mar; 54(3):268-73. PMID: 19047016.
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    38. Hu S, Arellano M, Boontheung P, Wang J, Zhou H, Jiang J, Elashoff D, Wei R, Loo JA, Wong DT. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res. 2008 Oct 01; 14(19):6246-52. PMID: 18829504.
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    39. Kim RH, Kim R, Chen W, Hu S, Shin KH, Park NH, Kang MK. Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells. Carcinogenesis. 2008 Dec; 29(12):2425-31. PMID: 18820283.
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    40. Zhang L, Jiang J, Arellano M, Zhang L, Yan X, Wong DT, Hu S. Quantification of Serum Proteins of Metastatic Oral Cancer Patients Using LC-MS/MS and iTRAQ Labeling. Open Proteomics J. 2008; 1:72-78. PMID: 20485468.
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    41. Hu S, Wang J, Meijer J, Ieong S, Xie Y, Yu T, Zhou H, Henry S, Vissink A, Pijpe J, Kallenberg C, Elashoff D, Loo JA, Wong DT. Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome. Arthritis Rheum. 2007 Nov; 56(11):3588-600. PMID: 17968930.
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    42. Hu S, Yen Y, Ann D, Wong DT. Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery. Drug Discov Today. 2007 Nov; 12(21-22):911-6. PMID: 17993408.
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    43. Hu S, Wong DT. Oral cancer proteomics. Curr Opin Mol Ther. 2007 Oct; 9(5):467-76. PMID: 17932810.
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    44. Hu S, Loo JA, Wong DT. Human saliva proteome analysis and disease biomarker discovery. Expert Rev Proteomics. 2007 Aug; 4(4):531-8. PMID: 17705710.
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    45. Hu S, Yu T, Xie Y, Yang Y, Li Y, Zhou X, Tsung S, Loo RR, Loo JR, Wong DT. Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry. Cancer Genomics Proteomics. 2007 Mar-Apr; 4(2):55-64. PMID: 17804867.
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    46. Hu S, Loo JA, Wong DT. Human saliva proteome analysis. Ann N Y Acad Sci. 2007 Mar; 1098:323-9. PMID: 17435138.
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    47. Hu S, Loo JA, Wong DT. Human body fluid proteome analysis. Proteomics. 2006 Dec; 6(23):6326-53. PMID: 17083142.
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    48. Hu S, Xie Y, Ramachandran P, Ogorzalek Loo RR, Li Y, Loo JA, Wong DT. Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry. Proteomics. 2005 Apr; 5(6):1714-28. PMID: 15800970.
      View in: PubMed
    49. Hu S, Denny P, Denny P, Xie Y, Loo JA, Wolinsky LE, Li Y, McBride J, Ogorzalek Loo RR, Navazesh M, Wong DT. Differentially expressed protein markers in human submandibular and sublingual secretions. Int J Oncol. 2004 Nov; 25(5):1423-30. PMID: 15492834.
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    50. Zhou X, Cole SW, Hu S, Wong DT. Detection of DNA copy number abnormality by microarray expression analysis. Hum Genet. 2004 Apr; 114(5):464-7. PMID: 14872338.
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