Loading...

Nusinowitz, Steven

Title(s)Professor-in-Residence, Ophthalmology
Phone60496
vCardDownload vCard

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Su F, Spee C, Araujo E, Barron E, Wang M, Ghione C, Hinton DR, Nusinowitz S, Kannan R, Reddy ST, Farias-Eisner R. A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration. Int J Mol Sci. 2019 Sep 27; 20(19). PMID: 31569695.
      View in: PubMed
    2. Gui W, Nusinowitz S, Sarraf D. NOVEL CONE DYSTROPHY WITH CENTRAL ELLIPSOID ZONE LOSS ASSOCIATED WITH HUMAN RETINAL FASCIN GENE (FSCN2) MUTATION. Retin Cases Brief Rep. 2018 Fall; 12 Suppl 1:S63-S66. PMID: 29016529.
      View in: PubMed
    3. Xu D, Su D, Nusinowitz S, Sarraf D. CENTRAL ELLIPSOID LOSS ASSOCIATED WITH CONE DYSTROPHY AND KCNV2 MUTATION. Retin Cases Brief Rep. 2018 Fall; 12 Suppl 1:S59-S62. PMID: 29210963.
      View in: PubMed
    4. Parikh S, Le A, Davenport J, Gorin MB, Nusinowitz S, Matynia A. An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach. J Vis Exp. 2016 12 07; (118). PMID: 28060316.
      View in: PubMed
    5. Matynia A, Nguyen E, Sun X, Blixt FW, Parikh S, Kessler J, Pérez de Sevilla Müller L, Habib S, Kim P, Wang ZZ, Rodriguez A, Charles A, Nusinowitz S, Edvinsson L, Barnes S, Brecha NC, Gorin MB. Peripheral Sensory Neurons Expressing Melanopsin Respond to Light. Front Neural Circuits. 2016; 10:60. PMID: 27559310.
      View in: PubMed
    6. Sarfare S, Dacquay Y, Askari S, Nusinowitz S, Hubschman JP. Biocompatibility of a Synthetic Biopolymer for the Treatment of Rhegmatogenous Retinal Detachment. J Clin Exp Ophthalmol. 2015 Oct; 6(5). PMID: 26744635.
      View in: PubMed
    7. Matynia A, Parikh S, Deot N, Wong A, Kim P, Nusinowitz S, Gorin MB. Light aversion and corneal mechanical sensitivity are altered by intrinscally photosensitive retinal ganglion cells in a mouse model of corneal surface damage. Exp Eye Res. 2015 Aug; 137:57-62. PMID: 26070985.
      View in: PubMed
    8. Gorin MB, Weeks DE, Baron RV, Conley YP, Ortube MC, Nusinowitz S. Endophenotypes for Age-Related Macular Degeneration: Extending Our Reach into the Preclinical Stages of Disease. J Clin Med. 2014 Nov 28; 3(4):1335-56. PMID: 25568804.
      View in: PubMed
    9. Ortube MC, Strom SP, Nelson SF, Nusinowitz S, Martinez A, Gorin MB. Whole exome sequencing detects homozygosity for ABCA4 p.Arg602Trp missense mutation in a pediatric patient with rapidly progressive retinal dystrophy. BMC Med Genet. 2014 Jan 20; 15:11. PMID: 24444108.
      View in: PubMed
    10. Rhee KD, Nusinowitz S, Chao K, Yu F, Bok D, Yang XJ. CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Müller glial cells. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4520-9. PMID: 24191003.
      View in: PubMed
    11. Pineles SL, Velez FG, Isenberg SJ, Fenoglio Z, Birch E, Nusinowitz S, Demer JL. Functional burden of strabismus: decreased binocular summation and binocular inhibition. JAMA Ophthalmol. 2013 Nov; 131(11):1413-9. PMID: 24052160.
      View in: PubMed
    12. Ortube MC, Kiderman A, Eydelman Y, Yu F, Aguilar N, Nusinowitz S, Gorin MB. Comparative regional pupillography as a noninvasive biosensor screening method for diabetic retinopathy. Invest Ophthalmol Vis Sci. 2013 Jan 02; 54(1):9-18. PMID: 23154459.
      View in: PubMed
    13. Kaylor JJ, Yuan Q, Cook J, Sarfare S, Makshanoff J, Miu A, Kim A, Kim P, Habib S, Roybal CN, Xu T, Nusinowitz S, Travis GH. Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina. Nat Chem Biol. 2013 Jan; 9(1):30-6. PMID: 23143414.
      View in: PubMed
    14. Matynia A, Parikh S, Chen B, Kim P, McNeill DS, Nusinowitz S, Evans C, Gorin MB. Intrinsically photosensitive retinal ganglion cells are the primary but not exclusive circuit for light aversion. Exp Eye Res. 2012 Dec; 105:60-9. PMID: 23078956.
      View in: PubMed
    15. Sham CW, Chan AM, Kwong JM, Caprioli J, Nusinowitz S, Chen B, Lee JG, Gandhi NM, Francisco LM, Sharpe AH, Chen L, Braun J, Gordon LK. Neuronal programmed cell death-1 ligand expression regulates retinal ganglion cell number in neonatal and adult mice. J Neuroophthalmol. 2012 Sep; 32(3):227-37. PMID: 22635166.
      View in: PubMed
    16. Strom SP, Gao YQ, Martinez A, Ortube C, Chen Z, Nelson SF, Nusinowitz S, Farber DB, Gorin MB. Molecular diagnosis of putative Stargardt Disease probands by exome sequencing. BMC Med Genet. 2012 Aug 03; 13:67. PMID: 22863181.
      View in: PubMed
    17. Ruiz A, Mark M, Jacobs H, Klopfenstein M, Hu J, Lloyd M, Habib S, Tosha C, Radu RA, Ghyselinck NB, Nusinowitz S, Bok D. Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6. Invest Ophthalmol Vis Sci. 2012 May 17; 53(6):3027-39. PMID: 22467576.
      View in: PubMed
    18. Engelhardt M, Tosha C, Lopes VS, Chen B, Nguyen L, Nusinowitz S, Williams DS. Functional and morphological analysis of the subretinal injection of retinal pigment epithelium cells. Vis Neurosci. 2012 Mar; 29(2):83-93. PMID: 22391151.
      View in: PubMed
    19. Sakagami K, Chen B, Nusinowitz S, Wu H, Yang XJ. PTEN regulates retinal interneuron morphogenesis and synaptic layer formation. Mol Cell Neurosci. 2012 Feb; 49(2):171-83. PMID: 22155156.
      View in: PubMed
    20. Kao L, Kurtz LM, Shao X, Papadopoulos MC, Liu L, Bok D, Nusinowitz S, Chen B, Stella SL, Andre M, Weinreb J, Luong SS, Piri N, Kwong JM, Newman D, Kurtz I. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J Biol Chem. 2011 Sep 16; 286(37):32563-74. PMID: 21705333.
      View in: PubMed
    21. Lopes VS, Jimeno D, Khanobdee K, Song X, Chen B, Nusinowitz S, Williams DS. Dysfunction of heterotrimeric kinesin-2 in rod photoreceptor cells and the role of opsin mislocalization in rapid cell death. Mol Biol Cell. 2010 Dec; 21(23):4076-88. PMID: 20926680.
      View in: PubMed
    22. Scott-McKean JJ, Chang B, Hurd RE, Nusinowitz S, Schmidt C, Davisson MT, Costa AC. The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3300-8. PMID: 20130276.
      View in: PubMed
    23. Bojanic DD, Tarr PT, Gale GD, Smith DJ, Bok D, Chen B, Nusinowitz S, Lövgren-Sandblom A, Björkhem I, Edwards PA. Differential expression and function of ABCG1 and ABCG4 during development and aging. J Lipid Res. 2010 Jan; 51(1):169-81. PMID: 19633360.
      View in: PubMed
    24. Tosha C, Gorin MB, Nusinowitz S. Test-retest reliability and inter-ocular symmetry of multi-focal electroretinography in Stargardt disease. Curr Eye Res. 2010 Jan; 35(1):63-72. PMID: 20021256.
      View in: PubMed
    25. Zandian M, Belisle R, Mott KR, Nusinowitz S, Hofman FM, Ghiasi H. Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3275-82. PMID: 19234357.
      View in: PubMed
    26. Jin M, Li S, Nusinowitz S, Lloyd M, Hu J, Radu RA, Bok D, Travis GH. The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors. J Neurosci. 2009 Feb 04; 29(5):1486-95. PMID: 19193895.
      View in: PubMed
    27. Nusinowitz S, Sarraf D. Retinal function in X-linked ocular albinism (OA1). Curr Eye Res. 2008 Sep; 33(9):789-803. PMID: 18798082.
      View in: PubMed
    28. Radu RA, Yuan Q, Hu J, Peng JH, Lloyd M, Nusinowitz S, Bok D, Travis GH. Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation. Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):3821-9. PMID: 18515570.
      View in: PubMed
    29. Souied EH, Reid SN, Piri NI, Lerner LE, Nusinowitz S, Farber DB. Non-invasive gene transfer by iontophoresis for therapy of an inherited retinal degeneration. Exp Eye Res. 2008 Sep; 87(3):168-75. PMID: 18653181.
      View in: PubMed
    30. Young A, Powelson EB, Whitney IE, Raven MA, Nusinowitz S, Jiang M, Birnbaumer L, Reese BE, Farber DB. Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):3245-52. PMID: 18378571.
      View in: PubMed
    31. Ruiz A, Ghyselinck NB, Mata N, Nusinowitz S, Lloyd M, Dennefeld C, Chambon P, Bok D. Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5377-87. PMID: 18055784.
      View in: PubMed
    32. Straatsma BR, Nusinowitz S, Young TA, Gordon LK, Chun MW, Rosen C, Seja E, Economou JS, Glaspy JA, Bozon V, Gomez-Navarro J, Ribas A. Surveillance of the eye and vision in clinical trials of CP-675,206 for metastatic melanoma. Am J Ophthalmol. 2007 Jun; 143(6):958-969. PMID: 17434437.
      View in: PubMed
    33. Tsang SH, Woodruff ML, Jun L, Mahajan V, Yamashita CK, Pedersen R, Lin CS, Goff SP, Rosenberg T, Larsen M, Farber DB, Nusinowitz S. Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness. Hum Mutat. 2007 Mar; 28(3):243-54. PMID: 17044014.
      View in: PubMed
    34. Nusinowitz S, Ridder WH, Ramirez J. Temporal response properties of the primary and secondary rod-signaling pathways in normal and Gnat2 mutant mice. Exp Eye Res. 2007 Jun; 84(6):1104-14. PMID: 17408617.
      View in: PubMed
    35. Chang B, Dacey MS, Hawes NL, Hitchcock PF, Milam AH, Atmaca-Sonmez P, Nusinowitz S, Heckenlively JR. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci. 2006 Nov; 47(11):5017-21. PMID: 17065522.
      View in: PubMed
    36. Holland GN, Shah KH, Monnet D, Brezin AP, Yu F, Nusinowitz S, Levinson RD. Longitudinal cohort study of patients with birdshot chorioretinopathy II: color vision at baseline. Am J Ophthalmol. 2006 Dec; 142(6):1013-8. PMID: 17157585.
      View in: PubMed
    37. Shah KH, Holland GN, Yu F, Van Natta M, Nusinowitz S. Contrast sensitivity and color vision in HIV-infected individuals without infectious retinopathy. Am J Ophthalmol. 2006 Aug; 142(2):284-92. PMID: 16876510.
      View in: PubMed
    38. Nusinowitz S, Ridder WH, Pang JJ, Chang B, Noorwez SM, Kaushal S, Hauswirth WW, Heckenlively JR. Cortical visual function in the rd12 mouse model of Leber Congenital Amarousis (LCA) after gene replacement therapy to restore retinal function. Vision Res. 2006 Oct; 46(22):3926-34. PMID: 16814838.
      View in: PubMed
    39. Kitamura E, Danciger M, Yamashita C, Rao NP, Nusinowitz S, Chang B, Farber DB. Disruption of the gene encoding the beta1-subunit of transducin in the Rd4/+ mouse. Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1293-301. PMID: 16565360.
      View in: PubMed
    40. Lyons BL, Smith RS, Hurd RE, Hawes NL, Burzenski LM, Nusinowitz S, Hasham MG, Chang B, Shultz LD. Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1201-9. PMID: 16505059.
      View in: PubMed
    41. Ronan S, Nusinowitz S, Swaroop A, Heckenlively JR. Senile panretinal cone dysfunction in age-related macular degeneration (AMD): a report of 52 amd patients compared to age-matched controls. Trans Am Ophthalmol Soc. 2006; 104:232-40. PMID: 17471344.
      View in: PubMed
    42. Chang B, Heckenlively JR, Bayley PR, Brecha NC, Davisson MT, Hawes NL, Hirano AA, Hurd RE, Ikeda A, Johnson BA, McCall MA, Morgans CW, Nusinowitz S, Peachey NS, Rice DS, Vessey KA, Gregg RG. The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses. Vis Neurosci. 2006 Jan-Feb; 23(1):11-24. PMID: 16597347.
      View in: PubMed
    43. Radu RA, Han Y, Bui TV, Nusinowitz S, Bok D, Lichter J, Widder K, Travis GH, Mata NL. Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4393-401. PMID: 16303925.
      View in: PubMed
    44. Elizabeth Rakoczy P, Yu MJ, Nusinowitz S, Chang B, Heckenlively JR. Mouse models of age-related macular degeneration. Exp Eye Res. 2006 May; 82(5):741-52. PMID: 16325179.
      View in: PubMed
    45. Pang JJ, Chang B, Kumar A, Nusinowitz S, Noorwez SM, Li J, Rani A, Foster TC, Chiodo VA, Doyle T, Li H, Malhotra R, Teusner JT, McDowell JH, Min SH, Li Q, Kaushal S, Hauswirth WW. Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis. Mol Ther. 2006 Mar; 13(3):565-72. PMID: 16223604.
      View in: PubMed
    46. Osorio Y, La Point SF, Nusinowitz S, Hofman FM, Ghiasi H. CD8+-dependent CNS demyelination following ocular infection of mice with a recombinant HSV-1 expressing murine IL-2. Exp Neurol. 2005 May; 193(1):1-18. PMID: 15817260.
      View in: PubMed
    47. Pang JJ, Chang B, Hawes NL, Hurd RE, Davisson MT, Li J, Noorwez SM, Malhotra R, McDowell JH, Kaushal S, Hauswirth WW, Nusinowitz S, Thompson DA, Heckenlively JR. Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA). Mol Vis. 2005 Feb 28; 11:152-62. PMID: 15765048.
      View in: PubMed
    48. Otani A, Dorrell MI, Kinder K, Moreno SK, Nusinowitz S, Banin E, Heckenlively J, Friedlander M. Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells. J Clin Invest. 2004 Sep; 114(6):765-74. PMID: 15372100.
      View in: PubMed
    49. Gordon LK, Ribas A, Nusinowitz S, Butterfield LH, Glaspy JA, Economou JS, Straatsma BR. Surveillance of the eye and vision in a clinical trial of MART1-transformed dendritic cells for metastatic melanoma. Control Clin Trials. 2004 Aug; 25(4):400-7. PMID: 15296814.
      View in: PubMed
    50. Radu RA, Mata NL, Nusinowitz S, Liu X, Travis GH. Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Novartis Found Symp. 2004; 255:51-63; discussion 63-7, 177-8. PMID: 14750596.
      View in: PubMed
    51. Nusinowitz S, Nguyen L, Radu R, Kashani Z, Farber D, Danciger M. Electroretinographic evidence for altered phototransduction gain and slowed recovery from photobleaches in albino mice with a MET450 variant in RPE65. Exp Eye Res. 2003 Nov; 77(5):627-38. PMID: 14550405.
      View in: PubMed
    52. Berezovsky A, Moraes NS, Nusinowitz S, Salomão SR. Standard full-field electroretinography in healthy preterm infants. Doc Ophthalmol. 2003 Nov; 107(3):243-9. PMID: 14711156.
      View in: PubMed
    53. Heckenlively JR, Hawes NL, Friedlander M, Nusinowitz S, Hurd R, Davisson M, Chang B. Mouse model of subretinal neovascularization with choroidal anastomosis. Retina. 2003 Aug; 23(4):518-22. PMID: 12972764.
      View in: PubMed
    54. Bok D, Galbraith G, Lopez I, Woodruff M, Nusinowitz S, BeltrandelRio H, Huang W, Zhao S, Geske R, Montgomery C, Van Sligtenhorst I, Friddle C, Platt K, Sparks MJ, Pushkin A, Abuladze N, Ishiyama A, Dukkipati R, Liu W, Kurtz I. Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3. Nat Genet. 2003 Jul; 34(3):313-9. PMID: 12808454.
      View in: PubMed
    55. Radu RA, Mata NL, Nusinowitz S, Liu X, Sieving PA, Travis GH. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4742-7. PMID: 12671074.
      View in: PubMed
    56. Udar N, Yelchits S, Chalukya M, Yellore V, Nusinowitz S, Silva-Garcia R, Vrabec T, Hussles Maumenee I, Donoso L, Small KW. Identification of GUCY2D gene mutations in CORD5 families and evidence of incomplete penetrance. Hum Mutat. 2003 Feb; 21(2):170-1. PMID: 12552567.
      View in: PubMed
    57. Ridder W, Nusinowitz S, Heckenlively JR. Causes of cataract development in anesthetized mice. Exp Eye Res. 2002 Sep; 75(3):365-70. PMID: 12384099.
      View in: PubMed
    58. Gao J, Cheon K, Nusinowitz S, Liu Q, Bei D, Atkins K, Azimi A, Daiger SP, Farber DB, Heckenlively JR, Pierce EA, Sullivan LS, Zuo J. Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5698-703. PMID: 11960024.
      View in: PubMed
    59. Nusinowitz S, Ridder WH, Heckenlively JR. Rod multifocal electroretinograms in mice. Invest Ophthalmol Vis Sci. 1999 Nov; 40(12):2848-58. PMID: 10549645.
      View in: PubMed
    60. Nusinowitz S, Birch DG, Birch EE. Rod photoresponses in 6-week and 4-month-old human infants. Vision Res. 1998 Mar; 38(5):627-35. PMID: 9604094.
      View in: PubMed