Steven D Schwartz

Title(s)Professor-in-Residence, Ophthalmology
SchoolMedicine
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    Dr. Steven D. Schwartz holds The Ahmanson Chair in Ophthalmology.

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    Rapid protein dynamics and catalysis: modulation by laboratory evolution, designed mutation, and protein control of electric field environment
    NIH R01GM127594Jan 1, 2019 - Nov 30, 2022
    Role: Principal Investigator
    A New Paradigm to Incorporate Protein Dynamics into Targeted Small Molecule Design for Sarcomeric Cardiomyopathies: A Proof of Concept for Thin Filament Therapeutics
    NIH R01HL137375Jan 1, 2018 - Dec 31, 2021
    Role: Co-Principal Investigator
    Quantum Nuclear Dynamics and Enzyme Chemistry
    NIH R21GM102226Sep 1, 2012 - Jun 30, 2015
    Role: Principal Investigator
    The interaction of myosin and the thin filament: how mutations cause allosteric dysfunction and their connection to genetic cardiomyopathy
    NIH R01HL107046Dec 15, 2010 - Jul 31, 2024
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reply. Retina. 2023 May 01; 43(5):e31-e32. Bonnet C, Chehaibou I, McCannel CA, McCannel TA, Prasad PS, Kreiger AE, Schwartz SD, Aldave A, Hubschman JP. PMID: 36763983.
      View in: PubMed   Mentions:    Fields:    
    2. Frosted Branch Angiitis in the Setting of Active COVID-19 Infection and Underlying Mixed Connective Tissue Disease. Cureus. 2023 Mar; 15(3):e36819. Hanson J, Dillon AB, Budoff G, Oh AJ, Goodyear K, Lorenzo M, Schwartz SD. PMID: 36998920; PMCID: PMC10048048.
      View in: PubMed   Mentions:
    3. Protein Dynamics and Enzymatic Catalysis. J Phys Chem B. 2023 Mar 21. Schwartz SD. PMID: 36944023.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Classical Molecular Dynamics Simulation of Glyonic Liquids: Structural Insights and Relation to Conductive Properties. J Phys Chem B. 2023 Feb 02; 127(4):921-931. Hei B, Pemberton JE, Schwartz SD. PMID: 36652632; PMCID: PMC9898233.
      View in: PubMed   Mentions:    Fields:    
    5. Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase. J Phys Chem B. 2023 01 12; 127(1):144-150. Frost CF, Balasubramani SG, Antoniou D, Schwartz SD. PMID: 36538016; PMCID: PMC9873402.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Insights into the Mechanism of the Cardiac Drug Omecamtiv Mecarbil-A Computational Study. J Phys Chem B. 2022 Dec 08; 126(48):10069-10082. Chakraborti A, Tardiff JC, Schwartz SD. PMID: 36448224.
      View in: PubMed   Mentions:    Fields:    
    7. Perspective: Path Sampling Methods Applied to Enzymatic Catalysis. J Chem Theory Comput. 2022 Nov 08; 18(11):6397-6406. Schwartz SD. PMID: 36305863; PMCID: PMC9677451.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. Post-Retinal Detachment Repair Diffuse Tractional Retinoschisis Sparing Region of Internal Limiting Membrane Peel. Ophthalmol Retina. 2022 09; 6(9):785. Budoff G, Schwartz SD, Hubschman JP. PMID: 35931642.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Transition Path Sampling Based Calculations of Free Energies for Enzymatic Reactions: The Case of Human Methionine Adenosyl Transferase and Plasmodium vivax Adenosine Deaminase. J Phys Chem B. 2022 07 28; 126(29):5413-5420. Balasubramani SG, Schwartz SD. PMID: 35830574; PMCID: PMC9444332.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    10. RAVIR: A Dataset and Methodology for the Semantic Segmentation and Quantitative Analysis of Retinal Arteries and Veins in Infrared Reflectance Imaging. IEEE J Biomed Health Inform. 2022 07; 26(7):3272-3283. Hatamizadeh A, Hosseini H, Patel N, Choi J, Pole CC, Hoeferlin CM, Schwartz SD, Terzopoulos D. PMID: 35349464.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Structure and Dynamics of the Flexible Cardiac Troponin T Linker Domain in a Fully Reconstituted Thin Filament. Biochemistry. 2022 07 05; 61(13):1229-1242. Deranek AE, Baldo AP, Lynn ML, Schwartz SD, Tardiff JC. PMID: 35696530; PMCID: PMC9257985.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    12. Free-Energy Surfaces of Two Cardiac Thin Filament Conformational Changes during Muscle Contraction. J Phys Chem B. 2022 06 02; 126(21):3844-3851. Mason AB, Tardiff JC, Schwartz SD. PMID: 35584206; PMCID: PMC9167776.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. Method for Identifying Common Features in Reactive Trajectories of a Transition Path Sampling Ensemble. J Chem Theory Comput. 2022 Jun 14; 18(6):3997-4004. Antoniou D, Schwartz SD. PMID: 35536190; PMCID: PMC9197981.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    14. RETINAL DETACHMENT IN EYES WITH BOSTON TYPE 1 KERATOPROSTHESIS: Surgical Techniques and Mid-Term Outcomes. Retina. 2022 05 01; 42(5):957-966. Bonnet C, Chehaibou I, McCannel CA, McCannel TA, Prasad PS, Kreiger AE, Schwartz SD, Aldave A, Hubschman JP. PMID: 34954778.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Correction to: Epiretinal proliferation after rhegmatogenous retinal detachment. Graefes Arch Clin Exp Ophthalmol. 2022 Apr; 260(4):1429. Pettenkofer M, Chehaibou I, Pole C, Rodriguez M, Rabina G, Kreiger AE, Schwartz SD, Hubschman JP. PMID: 35044506.
      View in: PubMed   Mentions:    Fields:    
    16. Engineered Tryptophan Synthase Balances Equilibrium Effects and Fast Dynamic Effects. ACS Catal. 2022 Jan 21; 12(2):913-922. Schafer JW, Chen X, Schwartz SD. PMID: 35719741; PMCID: PMC9202816.
      View in: PubMed   Mentions:
    17. Computational and biophysical determination of pathogenicity of variants of unknown significance in cardiac thin filament. JCI Insight. 2021 12 08; 6(23). Mason AB, Lynn ML, Baldo AP, Deranek AE, Tardiff JC, Schwartz SD. PMID: 34699384; PMCID: PMC8675185.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Epiretinal proliferation after rhegmatogenous retinal detachment. Graefes Arch Clin Exp Ophthalmol. 2022 May; 260(5):1509-1516. Pettenkofer M, Chehaibou I, Pole C, Rodriguez M, Rabina G, Kreiger AE, Schwartz SD, Hubschman JP. PMID: 34821991.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. PIGMENT EPITHELIAL DETACHMENT IN AGE-RELATED MACULAR DEGENERATION: Long-Term Visual Acuity May Improve With Higher Injection Index. Retina. 2021 Nov 01; 41(11):2229-2235. Gui W, Au A, Rabina G, Kapelushnik N, Cohen S, Masarwa D, Hosseini H, Heilweil G, Schwartz S, Loewenstein A, Schwartz SD. PMID: 34673665.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Inverse heavy enzyme isotope effects in methylthioadenosine nucleosidases. Proc Natl Acad Sci U S A. 2021 10 05; 118(40). Brown M, Zoi I, Antoniou D, Namanja-Magliano HA, Schwartz SD, Schramm VL. PMID: 34580228; PMCID: PMC8501826.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    21. Ophthalmology and COVID-19: The Impact of the Pandemic on Patient Care and Outcomes: An IRIS® Registry Study. Ophthalmology. 2021 12; 128(12):1782-1784. Leng T, Gallivan MD, Kras A, Lum F, Roe MT, Li C, Parke DW, Schwartz SD. PMID: 34144077; PMCID: PMC8213986.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    22. Investigation of the Recovery Stroke and ATP Hydrolysis and Changes Caused Due to the Cardiomyopathic Point Mutations in Human Cardiac β Myosin. J Phys Chem B. 2021 06 24; 125(24):6513-6521. Chakraborti A, Baldo AP, Tardiff JC, Schwartz SD. PMID: 34105970; PMCID: PMC8281501.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    23. A Proposed Mechanism for the Initial Myosin Binding Event on the Cardiac Thin Filament: A Metadynamics Study. J Phys Chem Lett. 2021 Apr 15; 12(14):3509-3513. Baldo AP, Tardiff JC, Schwartz SD. PMID: 33793247; PMCID: PMC8080310.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    24. Macular edema after rhegmatogenous retinal detachment repair: risk factors, OCT analysis, and treatment responses. Int J Retina Vitreous. 2021 Jan 25; 7(1):9. Pole C, Chehaibou I, Govetto A, Garrity S, Schwartz SD, Hubschman JP. PMID: 33494835; PMCID: PMC7831177.
      View in: PubMed   Mentions: 3  
    25. Clinical characteristics and visual outcomes of non-resolving subretinal fluid in neovascular AMD despite continuous monthly anti-VEGF injections: a long-term follow-up. Graefes Arch Clin Exp Ophthalmol. 2021 May; 259(5):1153-1160. Hosseini H, Rabina G, Pettenkofer M, Au A, Chehaibou I, Heilweil G, Weiner AJ, Ip M, Loewenstein A, Schwartz SD. PMID: 33245430.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Mechanochemical Function of Myosin II: Investigation into the Recovery Stroke and ATP Hydrolysis. J Phys Chem B. 2020 11 12; 124(45):10014-10023. Baldo AP, Tardiff JC, Schwartz SD. PMID: 33136401; PMCID: PMC7696650.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    27. Role of Protein Motions in Catalysis by Formate Dehydrogenase. J Phys Chem B. 2020 10 29; 124(43):9483-9489. Antoniou D, Schwartz SD. PMID: 33064490; PMCID: PMC7697370.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    28. Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts. JCI Insight. 2020 10 15; 5(20). Powers JD, Kooiker KB, Mason AB, Teitgen AE, Flint GV, Tardiff JC, Schwartz SD, McCulloch AD, Regnier M, Davis J, Moussavi-Harami F. PMID: 32931484; PMCID: PMC7605524.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    29. Multiple Reaction Pathways in the Morphinone Reductase-Catalyzed Hydride Transfer Reaction. ACS Omega. 2020 Sep 15; 5(36):23468-23480. Chen X, Schwartz SD. PMID: 32954200; PMCID: PMC7496013.
      View in: PubMed   Mentions: 2  
    30. Directed Evolution's Influence on Rapid Density Fluctuations Illustrates How Protein Dynamics Can Become Coupled to Chemistry. ACS Catal. 2020 Aug 07; 10(15):8476-8484. Schafer JW, Schwartz SD. PMID: 33163256; PMCID: PMC7643869.
      View in: PubMed   Mentions: 6  
    31. DETECTION OF NEUROSENSORY RETINAL DETACHMENT COMPLICATING DEGENERATIVE RETINOSCHISIS BY ULTRA-WIDEFIELD FUNDUS AUTOFLUORESCENCE IMAGING. Retina. 2020 May; 40(5):819-824. Francone A, Kothari N, Farajzadeh M, Hosseini H, Prasad P, Schwartz S, Hubschman JP. PMID: 31397744; PMCID: PMC7176347.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. A Classical Molecular Dynamics Simulation Study of Interfacial and Bulk Solution Aggregation Properties of Dirhamnolipids. J Phys Chem B. 2020 02 06; 124(5):814-827. Luft CM, Munusamy E, Pemberton JE, Schwartz SD. PMID: 31958226; PMCID: PMC7042949.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    33. Clinic-based ultra-wide field retinal imaging in a pediatric population. Int J Retina Vitreous. 2019; 5(Suppl 1):21. Kothari N, Pineles S, Sarraf D, Velez F, Heilweil G, Holland G, McCannel CA, Onclinx T, McCannel TA, Sadda SR, Schwartz SD, Tsui I. PMID: 31890284; PMCID: PMC6907107.
      View in: PubMed   Mentions: 5  
    34. Examining the Origin of Catalytic Power of Catechol O-Methyltransferase. ACS Catal. 2019 Nov 01; 9(11):9870-9879. Chen X, Schwartz SD. PMID: 31750009; PMCID: PMC6865801.
      View in: PubMed   Mentions: 9  
    35. Retinal stem cell transplantation: Balancing safety and potential. Prog Retin Eye Res. 2020 03; 75:100779. Singh MS, Park SS, Albini TA, Canto-Soler MV, Klassen H, MacLaren RE, Takahashi M, Nagiel A, Schwartz SD, Bharti K. PMID: 31494256; PMCID: PMC7056514.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    36. FRET-based analysis of the cardiac troponin T linker region reveals the structural basis of the hypertrophic cardiomyopathy-causing Δ160E mutation. J Biol Chem. 2019 10 04; 294(40):14634-14647. Abdullah S, Lynn ML, McConnell MT, Klass MM, Baldo AP, Schwartz SD, Tardiff JC. PMID: 31387947; PMCID: PMC6779437.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    37. Optimization of the Turnover in Artificial Enzymes via Directed Evolution Results in the Coupling of Protein Dynamics to Chemistry. J Am Chem Soc. 2019 07 03; 141(26):10431-10439. Schafer JW, Zoi I, Antoniou D, Schwartz SD. PMID: 31199129; PMCID: PMC6610584.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    38. Proof of Principle that Molecular Modeling Followed by a Biophysical Experiment Can Develop Small Molecules that Restore Function to the Cardiac Thin Filament in the Presence of Cardiomyopathic Mutations. ACS Omega. 2019 Apr 30; 4(4):6492-6501. Szatkowski L, Lynn ML, Holeman T, Williams MR, Baldo AP, Tardiff JC, Schwartz SD. PMID: 31342001; PMCID: PMC6649307.
      View in: PubMed   Mentions: 4  
    39. Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6209-E6216. Harijan RK, Zoi I, Antoniou D, Schwartz SD, Schramm VL. PMID: 29915028; PMCID: PMC6142206.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    40. Unraveling the Differential Aggregation of Anionic and Nonionic Monorhamnolipids at Air-Water and Oil-Water Interfaces: A Classical Molecular Dynamics Simulation Study. J Phys Chem B. 2018 06 21; 122(24):6403-6416. Munusamy E, Luft CM, Pemberton JE, Schwartz SD. PMID: 29856614; PMCID: PMC6075951.
      View in: PubMed   Mentions: 5     Fields:    
    41. Mechanism of Cardiac Tropomyosin Transitions on Filamentous Actin As Revealed by All-Atom Steered Molecular Dynamics Simulations. J Phys Chem Lett. 2018 Jun 21; 9(12):3301-3306. Williams MR, Tardiff JC, Schwartz SD. PMID: 29863359; PMCID: PMC6019281.
      View in: PubMed   Mentions: 10     Fields:    
    42. Promoting Vibrations and the Function of Enzymes. Emerging Theoretical and Experimental Convergence. Biochemistry. 2018 06 19; 57(24):3299-3308. Schramm VL, Schwartz SD. PMID: 29608286; PMCID: PMC6008225.
      View in: PubMed   Mentions: 22     Fields:    
    43. EARLY DETECTION OF RETINAL HEMANGIOBLASTOMAS IN VON HIPPEL-LINDAU DISEASE USING ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY. Retina. 2018 Apr; 38(4):748-754. Chen X, Sanfilippo CJ, Nagiel A, Hosseini H, Mitchell D, McCannel CA, Schwartz SD, McCannel TA. PMID: 28368975.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    44. Molecular Dynamics Simulation of the Oil Sequestration Properties of a Nonionic Rhamnolipid. J Phys Chem B. 2018 04 12; 122(14):3944-3952. Luft CM, Munusamy E, Pemberton JE, Schwartz SD. PMID: 29547289; PMCID: PMC5931930.
      View in: PubMed   Mentions: 2     Fields:    
    45. Directed Evolution as a Probe of Rate Promoting Vibrations Introduced via Mutational Change. Biochemistry. 2018 06 12; 57(23):3289-3298. Chen X, Schwartz SD. PMID: 29553716; PMCID: PMC5997552.
      View in: PubMed   Mentions: 6     Fields:    
    46. Human embryonic stem cells extracellular vesicles and their effects on immortalized human retinal Müller cells. PLoS One. 2018; 13(3):e0194004. Peng Y, Baulier E, Ke Y, Young A, Ahmedli NB, Schwartz SD, Farber DB. PMID: 29538408; PMCID: PMC5851617.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    47. ULTRAWIDEFIELD AUTOFLUORESENCE IN ABCA4 STARGARDT DISEASE. Retina. 2018 Feb; 38(2):403-415. Klufas MA, Tsui I, Sadda SR, Hosseini H, Schwartz SD. PMID: 28248825.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    48. Mechanistic Insights on Human Phosphoglucomutase Revealed by Transition Path Sampling and Molecular Dynamics Calculations. Chemistry. 2018 Feb 06; 24(8):1978-1987. Brás NF, Fernandes PA, Ramos MJ, Schwartz SD. PMID: 29131453; PMCID: PMC5801119.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    49. Association of Psychiatric Diagnostic Conditions with Hospital Care Outcomes of Patients with Orthopedic Injuries. Perm J. 2018; 22:17-120. Schwartz S, Bazargan-Hejazi S, Pan D, Ruiz D, Shirazi A, Washington E. PMID: 29702056; PMCID: PMC5922806.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    50. Electric Fields and Fast Protein Dynamics in Enzymes. J Phys Chem Lett. 2017 Dec 21; 8(24):6165-6170. Zoi I, Antoniou D, Schwartz SD. PMID: 29220191; PMCID: PMC5769145.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    51. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEA IN CHILDREN BORN PRETERM. Retina. 2017 Dec; 37(12):2289-2294. Falavarjani KG, Iafe NA, Velez FG, Schwartz SD, Sadda SR, Sarraf D, Tsui I. PMID: 28098735.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    52. Comparison of Outcomes between Endoscopic and Transcleral Cyclophotocoagulation. Vision (Basel). 2017 Nov 06; 1(4). Beardsley R, Law SK, Caprioli J, Coleman AL, Nouri-Mahdavi K, Hubschman JP, Schwartz SD, Giaconi JA. PMID: 31740649; PMCID: PMC6835382.
      View in: PubMed   Mentions: 4  
    53. Intraocular robotic interventional surgical system (IRISS): Mechanical design, evaluation, and master-slave manipulation. Int J Med Robot. 2018 Feb; 14(1). Wilson JT, Gerber MJ, Prince SW, Chen CW, Schwartz SD, Hubschman JP, Tsao TC. PMID: 28762253.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    54. Evolution of Aggregate Structure in Solutions of Anionic Monorhamnolipids: Experimental and Computational Results. Langmuir. 2017 08 01; 33(30):7412-7424. Eismin RJ, Munusamy E, Kegel LL, Hogan DE, Maier RM, Schwartz SD, Pemberton JE. PMID: 28737038; PMCID: PMC5767468.
      View in: PubMed   Mentions: 8     Fields:    
    55. Incorporating Fast Protein Dynamics into Enzyme Design: A Proposed Mutant Aromatic Amine Dehydrogenase. J Phys Chem B. 2017 08 03; 121(30):7290-7298. Zoi I, Antoniou D, Schwartz SD. PMID: 28696108; PMCID: PMC5763476.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    56. Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap. Biochemistry. 2017 07 05; 56(26):3403-3413. McConnell M, Tal Grinspan L, Williams MR, Lynn ML, Schwartz BA, Fass OZ, Schwartz SD, Tardiff JC. PMID: 28603979; PMCID: PMC5575768.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    57. Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase. Proc Natl Acad Sci U S A. 2017 06 20; 114(25):6456-6461. Harijan RK, Zoi I, Antoniou D, Schwartz SD, Schramm VL. PMID: 28584087; PMCID: PMC5488955.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    58. Structural Properties of Nonionic Monorhamnolipid Aggregates in Water Studied by Classical Molecular Dynamics Simulations. J Phys Chem B. 2017 06 15; 121(23):5781-5793. Munusamy E, Luft CM, Pemberton JE, Schwartz SD. PMID: 28535051; PMCID: PMC5562376.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    59. Structurally Linked Dynamics in Lactate Dehydrogenases of Evolutionarily Distinct Species. Biochemistry. 2017 05 16; 56(19):2488-2496. Varga MJ, Dzierlenga MW, Schwartz SD. PMID: 28445027; PMCID: PMC5507060.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    60. Gene Therapy in Neovascular Age-related Macular Degeneration: Three-Year Follow-up of a Phase 1 Randomized Dose Escalation Trial. Am J Ophthalmol. 2017 May; 177:150-158. Constable IJ, Lai CM, Magno AL, French MA, Barone SB, Schwartz SD, Blumenkranz MS, Degli-Esposti MA, Rakoczy EP. PMID: 28245970.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCTClinical Trials
    61. CORRELATION OF MULTIMODAL IMAGING IN SICKLE CELL RETINOPATHY. Retina. 2016 Dec; 36 Suppl 1:S111-S117. Ghasemi Falavarjani K, Scott AW, Wang K, Han IC, Chen X, Klufas M, Hubschman JP, Schwartz SD, Sadda SR, Sarraf D, Tsui I. PMID: 28005669.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    62. Phase 2a Randomized Clinical Trial: Safety and Post Hoc Analysis of Subretinal rAAV.sFLT-1 for Wet Age-related Macular Degeneration. EBioMedicine. 2016 Dec; 14:168-175. Constable IJ, Pierce CM, Lai CM, Magno AL, Degli-Esposti MA, French MA, McAllister IL, Butler S, Barone SB, Schwartz SD, Blumenkranz MS, Rakoczy EP. PMID: 27865764; PMCID: PMC5161436.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCellsCTClinical Trials
    63. Deformation of Optic Nerve Head and Peripapillary Tissues by Horizontal Duction. Am J Ophthalmol. 2017 Feb; 174:85-94. Chang MY, Shin A, Park J, Nagiel A, Lalane RA, Schwartz SD, Demer JL. PMID: 27751810; PMCID: PMC5812679.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    64. Gene Therapy and Stem Cell Transplantation in Retinal Disease: The New Frontier. Ophthalmology. 2016 10; 123(10S):S98-S106. MacLaren RE, Bennett J, Schwartz SD. PMID: 27664291; PMCID: PMC5545086.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    65. Conformational Heterogeneity in the Michaelis Complex of Lactate Dehydrogenase: An Analysis of Vibrational Spectroscopy Using Markov and Hidden Markov Models. J Phys Chem B. 2016 07 14; 120(27):6612-20. Pan X, Schwartz SD. PMID: 27347759; PMCID: PMC4945396.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    66. Gene Therapy for Age-Related Macular Degeneration. Asia Pac J Ophthalmol (Phila). 2016 Jul-Aug; 5(4):300-3. Constable IJ, Blumenkranz MS, Schwartz SD, Barone S, Lai CM, Rakoczy EP. PMID: 27488071.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    67. Targeting a Rate-Promoting Vibration with an Allosteric Mediator in Lactate Dehydrogenase. J Phys Chem Lett. 2016 Jul 07; 7(13):2591-6. Dzierlenga MW, Schwartz SD. PMID: 27327209; PMCID: PMC4939807.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    68. ULTRA-WIDEFIELD FUNDUS IMAGING: A Review of Clinical Applications and Future Trends. Retina. 2016 Apr; 36(4):660-78. Nagiel A, Lalane RA, Sadda SR, Schwartz SD. PMID: 27014860.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    69. Subretinal Transplantation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration: An Assessment at 4 Years. Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(5):ORSFc1-9. Schwartz SD, Tan G, Hosseini H, Nagiel A. PMID: 27116660.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    70. Enzymatic Kinetic Isotope Effects from First-Principles Path Sampling Calculations. J Chem Theory Comput. 2016 Apr 12; 12(4):2047-54. Varga MJ, Schwartz SD. PMID: 26949835; PMCID: PMC4829465.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    71. Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics. J Am Chem Soc. 2016 Mar 16; 138(10):3403-9. Zoi I, Suarez J, Antoniou D, Cameron SA, Schramm VL, Schwartz SD. PMID: 26927977; PMCID: PMC4794390.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    72. Atomic resolution probe for allostery in the regulatory thin filament. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3257-62. Williams MR, Lehman SJ, Tardiff JC, Schwartz SD. PMID: 26957598; PMCID: PMC4812746.
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    73. Lamellar Macular Hole: Two Distinct Clinical Entities? Am J Ophthalmol. 2016 Apr; 164:99-109. Govetto A, Dacquay Y, Farajzadeh M, Platner E, Hirabayashi K, Hosseini H, Schwartz SD, Hubschman JP. PMID: 26898164.
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    74. Phase Space Bottlenecks in Enzymatic Reactions. J Phys Chem B. 2016 Jan 28; 120(3):433-9. Antoniou D, Schwartz SD. PMID: 26756622; PMCID: PMC4734068.
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    75. Hydride Transfer in DHFR by Transition Path Sampling, Kinetic Isotope Effects, and Heavy Enzyme Studies. Biochemistry. 2016 Jan 12; 55(1):157-66. Wang Z, Antoniou D, Schwartz SD, Schramm VL. PMID: 26652185; PMCID: PMC4752833.
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    76. Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial. Lancet. 2015 Dec 12; 386(10011):2395-403. Rakoczy EP, Lai CM, Magno AL, Wikstrom ME, French MA, Pierce CM, Schwartz SD, Blumenkranz MS, Chalberg TW, Degli-Esposti MA, Constable IJ. PMID: 26431823.
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    77. The Great Imitator: Ocular Syphilis Presenting as Posterior Uveitis. Am J Case Rep. 2015 Jul 07; 16:434-7. Kuo A, Ziaee SM, Hosseini H, Voleti V, Schwartz SD, Kim NU, Ge PS. PMID: 26151369; PMCID: PMC4500594.
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    78. Stem cells in age-related macular degeneration and Stargardt's macular dystrophy - Authors' reply. Lancet. 2015 Jul 04; 386(9988):30. Schwartz SD, Anglade E, Lanza R, Ocata Macular Disease Investigator Group. PMID: 26169867.
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    79. Reliability of Ischemic Index Grading in Common Retinal Vascular Diseases. Ophthalmic Surg Lasers Imaging Retina. 2015 Jun; 46(6):618-25. Tsui I, Williams BK, Kok YO, Heilweil G, Schwartz SD. PMID: 26114841.
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    80. Free energy surface of the Michaelis complex of lactate dehydrogenase: a network analysis of microsecond simulations. J Phys Chem B. 2015 Apr 30; 119(17):5430-6. Pan X, Schwartz SD. PMID: 25831215; PMCID: PMC4748716.
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    81. Another Look at the Mechanisms of Hydride Transfer Enzymes with Quantum and Classical Transition Path Sampling. J Phys Chem Lett. 2015 Apr 02; 6(7):1177-81. Dzierlenga MW, Antoniou D, Schwartz SD. PMID: 26262969; PMCID: PMC4749019.
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    82. Enzyme homologues have distinct reaction paths through their transition states. J Phys Chem B. 2015 Mar 05; 119(9):3662-8. Zoi I, Motley MW, Antoniou D, Schramm VL, Schwartz SD. PMID: 25650981; PMCID: PMC4385586.
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    83. Diabetic tractional retinal detachment repair by vitreoretinal fellows in a county health system. Retina. 2015 Feb; 35(2):303-9. Rahimy E, Pitcher JD, Gee CJ, Kreiger AE, Schwartz SD, Hubschman JP. PMID: 25105314.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    84. Adaptive optics microperimetry and OCT images show preserved function and recovery of cone visibility in macular telangiectasia type 2 retinal lesions. Invest Ophthalmol Vis Sci. 2015 Jan 13; 56(2):778-86. Wang Q, Tuten WS, Lujan BJ, Holland J, Bernstein PS, Schwartz SD, Duncan JL, Roorda A. PMID: 25587056; PMCID: PMC4315435.
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    85. RESOLUTION OF A GIANT PIGMENT EPITHELIAL DETACHMENT WITH HALF-DOSE AFLIBERCEPT. Retin Cases Brief Rep. 2015; 9(4):269-72. Nagiel A, Sadda SR, Schwartz SD, Sarraf D. PMID: 26237136.
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    86. SUBRETINAL NEOVASCULARIZATION IN MACULAR TELANGIECTASIA TYPE 2: OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY AND TREATMENT RESPONSE. Retin Cases Brief Rep. 2015; 9(4):286-9. Tan GS, Kuehlewein L, Sadda SR, Sarraf D, Schwartz SD. PMID: 26288110.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    87. Ciliary neurotrophic factor for macular telangiectasia type 2: results from a phase 1 safety trial. Am J Ophthalmol. 2015 Apr; 159(4):659-666.e1. Chew EY, Clemons TE, Peto T, Sallo FB, Ingerman A, Tao W, Singerman L, Schwartz SD, Peachey NS, Bird AC, MacTel-CNTF Research Group. PMID: 25528956; PMCID: PMC4361328.
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    88. Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist. ACS Med Chem Lett. 2015 Feb 12; 6(2):192-7. Van der Poorten O, Fehér K, Buysse K, Feytens D, Zoi I, Schwartz SD, Martins JC, Tourwé D, Cai M, Hruby VJ, Ballet S. PMID: 25699148; PMCID: PMC4329577.
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    89. Evolution alters the enzymatic reaction coordinate of dihydrofolate reductase. J Phys Chem B. 2015 Jan 22; 119(3):989-96. Masterson JE, Schwartz SD. PMID: 25369552; PMCID: PMC4306496.
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    90. The enzymatic reaction catalyzed by lactate dehydrogenase exhibits one dominant reaction path. Chem Phys. 2014 Oct 16; 442(17):132-136. Masterson JE, Schwartz SD. PMID: 25368440; PMCID: PMC4215548.
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    91. Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies. Lancet. 2015 Feb 07; 385(9967):509-16. Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ, Gregori NZ, Hubschman JP, Davis JL, Heilwell G, Spirn M, Maguire J, Gay R, Bateman J, Ostrick RM, Morris D, Vincent M, Anglade E, Del Priore LV, Lanza R. PMID: 25458728.
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    92. Morphologic features and evolution of inner retinal dimples on optical coherence tomography after internal limiting membrane peeling. Retina. 2014 Oct; 34(10):2096-102. Amouyal F, Shah SU, Pan CK, Schwartz SD, Hubschman JP. PMID: 24859477.
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    93. Conformational freedom in tight binding enzymatic transition-state analogues. J Phys Chem B. 2013 Aug 22; 117(33):9591-7. Motley MW, Schramm VL, Schwartz SD. PMID: 23895500; PMCID: PMC3786605.
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    94. Embryonic stem cells as a treatment for macular degeneration. Expert Opin Biol Ther. 2013 Aug; 13(8):1125-33. Pan CK, Heilweil G, Lanza R, Schwartz SD. PMID: 23705996.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    95. Peripheral fluorescein angiographic findings in fellow eyes of patients with branch retinal vein occlusion. Int J Inflam. 2013; 2013:464127. Tsui I, Bajwa A, Franco-Cardenas V, Pan CK, Kim HY, Schwartz SD. PMID: 23607044; PMCID: PMC3626174.
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    96. Changes in protein architecture and subpicosecond protein dynamics impact the reaction catalyzed by lactate dehydrogenase. J Phys Chem A. 2013 Aug 15; 117(32):7107-13. Masterson JE, Schwartz SD. PMID: 23441954; PMCID: PMC3695017.
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    97. Postoperative posterior segment complications in eyes treated with the Boston type I keratoprosthesis. Retina. 2013 Mar; 33(3):532-41. Goldman DR, Hubschman JP, Aldave AJ, Chiang A, Huang JS, Bourges JL, Schwartz SD. PMID: 23073339.
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    98. Dramatic resolution of extreme ocular ischemia in a case of Takayasu's arteritis. Ophthalmic Surg Lasers Imaging Retina. 2013 Mar-Apr; 44(2):198-200. Goldman DR, Prasad PS, Schwartz SD. PMID: 23410509.
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    99. Pediatric retinal conditions imaged by ultra wide field fluorescein angiography. Ophthalmic Surg Lasers Imaging Retina. 2013 Jan-Feb; 44(1):59-67. Tsui I, Franco-Cardenas V, Hubschman JP, Schwartz SD. PMID: 23410810.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    100. Effect of cut rates on fluidic behavior of chopped vitreous. Retina. 2013 Jan; 33(1):166-9. Sharif-Kashani P, Nishida K, Pirouz Kavehpour H, Schwartz SD, Hubschman JP. PMID: 22914683.
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    101. Protein dynamics and the enzymatic reaction coordinate. Top Curr Chem. 2013; 337:189-208. Schwartz SD. PMID: 23508766; PMCID: PMC4346281.
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    102. Mass Modulation of Protein Dynamics Associated with Barrier Crossing in Purine Nucleoside Phosphorylase. J Phys Chem Lett. 2012 Dec 06; 3(23):3538-3544. Antoniou D, Ge X, Schramm VL, Schwartz SD. PMID: 24496053; PMCID: PMC3564558.
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    103. Removal of posterior segment retained lens material using the OZil phacoemulsification handpiece versus Fragmatome during pars plana vitrectomy. Retina. 2012 Nov-Dec; 32(10):2119-26. Chiang A, Garg SJ, Alshareef RA, Pitcher JD, Hu AY, Spirn MJ, Hsu J, Lane RG, Regillo CD, Ho AC, Schwartz SD. PMID: 22718151.
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    104. Ocriplasmin for vitreoretinal diseases. J Biomed Biotechnol. 2012; 2012:354979. Tsui I, Pan CK, Rahimy E, Schwartz SD. PMID: 23193358; PMCID: PMC3496214.
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    105. Molecular effects of familial hypertrophic cardiomyopathy-related mutations in the TNT1 domain of cTnT. J Mol Biol. 2012 Aug 03; 421(1):54-66. Manning EP, Tardiff JC, Schwartz SD. PMID: 22579624; PMCID: PMC3545441.
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    106. Ultra wide field fluorescein angiography can detect macular pathology in central retinal vein occlusion. Ophthalmic Surg Lasers Imaging. 2012 May-Jun; 43(3):257-62. Tsui I, Franco-Cardenas V, Hubschman JP, Yu F, Schwartz SD. PMID: 22587468.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    107. Short-duration focal pattern grid photocoagulation for macular edema secondary to branch retinal vein occlusion. Semin Ophthalmol. 2012 May-Jul; 27(3-4):69-72. Pitcher JD, Liu T, Prasad PS, Schwartz SD, Hubschman JP. PMID: 22784269.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    108. Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet. 2012 Feb 25; 379(9817):713-20. Schwartz SD, Hubschman JP, Heilwell G, Franco-Cardenas V, Pan CK, Ostrick RM, Mickunas E, Gay R, Klimanskaya I, Lanza R. PMID: 22281388.
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    109. Barrier Crossing in Dihydrofolate Reductasedoes not involve a rate-promoting vibration. Mol Phys. 2012 May 10; 110(9-10):531-536. Dametto M, Antoniou D, Schwartz SD. PMID: 22942460; PMCID: PMC3430383.
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    110. The promoting vibration in human heart lactate dehydrogenase is a preferred vibrational channel. J Phys Chem B. 2011 Dec 29; 115(51):15439-44. Davarifar A, Antoniou D, Schwartz SD. PMID: 22077414; PMCID: PMC3245336.
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    111. Protein dynamics and enzymatic chemical barrier passage. J Phys Chem B. 2011 Dec 29; 115(51):15147-58. Antoniou D, Schwartz SD. PMID: 22031954; PMCID: PMC3245361.
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    112. Response to Comment on "Towards identification of the reaction coordinate directly from the transition state ensemble using the kernel PCA method" by D. Antoniou and S. Schwartz, J. Phys. Chem. B. 115, 2465-2469 (2011). J Phys Chem B. 2011 Nov 03; 115(43):12674-12675. Antoniou D, Schwartz SD. PMID: 23741196; PMCID: PMC3670703.
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    113. A pilot study of normative data for macular thickness and volume measurements using cirrus high-definition optical coherence tomography. Retina. 2011 Oct; 31(9):1944-50. Liu T, Hu AY, Kaines A, Yu F, Schwartz SD, Hubschman JP. PMID: 21499190.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    114. Endophthalmitis in microincision vitrectomy: outcomes of gas-filled eyes. Retina. 2011 Sep; 31(8):1513-7. Chiang A, Kaiser RS, Avery RL, Dugel PU, Eliott D, Shah SP, Heier J, Duker J, Hu AY, Schwartz SD, Scott IU, Pollack JS, Faia LJ, Williams GA. PMID: 21878799.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    115. Diagnostic and therapeutic challenges. Retina. 2011 Sep; 31(8):1726-31. Telander DG, Hielweil G, Schwartz SD, Butler FK. PMID: 21610565.
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    116. A model of calcium activation of the cardiac thin filament. Biochemistry. 2011 Aug 30; 50(34):7405-13. Manning EP, Tardiff JC, Schwartz SD. PMID: 21797264; PMCID: PMC3165030.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    117. Toward Identification of the reaction coordinate directly from the transition state ensemble using the kernel PCA method. J Phys Chem B. 2011 Mar 17; 115(10):2465-9. Antoniou D, Schwartz SD. PMID: 21332236; PMCID: PMC3058940.
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    118. Finite temperature application of the corrected propagator method to reactive dynamics in a condensed-phase environment. J Chem Phys. 2011 Jan 21; 134(3):034109. Gelman D, Schwartz SD. PMID: 21261332; PMCID: PMC3041154.
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    119. Ischemic index and neovascularization in central retinal vein occlusion. Retina. 2011 Jan; 31(1):105-10. Tsui I, Kaines A, Havunjian MA, Hubschman S, Heilweil G, Prasad PS, Oliver SC, Yu F, Bitrian E, Hubschman JP, Friberg T, Schwartz SD. PMID: 21099454.
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    120. Assessment of a hexapod surgical system for robotic micro-macro manipulations in ocular surgery. Ophthalmic Res. 2011; 46(1):25-30. Bourges JL, Hubschman JP, Wilson J, Prince S, Tsao TC, Schwartz S. PMID: 21109761.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    121. Slow conformational motions that favor sub-picosecond motions important for catalysis. J Phys Chem B. 2010 Dec 09; 114(48):15985-90. Pineda JR, Antoniou D, Schwartz SD. PMID: 21077591; PMCID: PMC3018068.
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    122. Short-duration focal pattern grid macular photocoagulation for diabetic macular edema: four-month outcomes. Retina. 2010 Nov-Dec; 30(10):1622-6. Jain A, Collen J, Kaines A, Hubschman JP, Schwartz S. PMID: 21060272.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    123. Ultra-wide-field and autofluorescence imaging of choroidal dystrophies. Ophthalmic Surg Lasers Imaging. 2010 Oct 28; 41 Online:e1-5. Yuan A, Kaines A, Jain A, Reddy S, Schwartz SD, Sarraf D. PMID: 21053862.
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    124. Limited long-term efficacy of intravitreous anti-VEGF pharmacotherapy in sarcoidosis complicated by peripapillary choroidal neovascular membrane. Acta Ophthalmol. 2010 Sep; 88(6):e243-4. Shah SP, Hubschman JP, Bourges JL, Hu AY, Schwartz SD. PMID: 19740129.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    125. On the Origin of the Chemical Barrier and Tunneling in Enzymes. J Phys Org Chem. 2010 Jul 01; 23(7):690-695. Machleder SQ, Pineda ET, Schwartz SD. PMID: 20582160; PMCID: PMC2889710.
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    126. Diagnostic and therapeutic challenges. Retina. 2010 Jun; 30(6):975-80. Gupta OP, Garg SJ, Negrey JN, Jahnle R, Pasion R, Ip MS, Hwang FS, Kaines A, Jain AK, Schwartz SD. PMID: 20531147.
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    127. A current method to collect an undiluted vitrectomy sample. Retina. 2010 May; 30(5):830-1. Tsui I, Schwartz SD, Hubschman JP. PMID: 20453804.
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    128. A placebo-controlled trial of microplasmin intravitreous injection to facilitate posterior vitreous detachment before vitrectomy. Ophthalmology. 2010 Apr; 117(4):791-7. Benz MS, Packo KH, Gonzalez V, Pakola S, Bezner D, Haller JA, Schwartz SD. PMID: 20138368.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCTClinical Trials
    129. Age-related macular degeneration: current and novel therapies. Maturitas. 2010 May; 66(1):46-50. Prasad PS, Schwartz SD, Hubschman JP. PMID: 20219298.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    130. Bilateral central serous chorioretinopathy resolving rapidly with treatment for obstructive sleep apnea. Graefes Arch Clin Exp Ophthalmol. 2010 Jul; 248(7):1037-9. Jain AK, Kaines A, Schwartz S. PMID: 20049474.
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    131. Ultra wide-field angiographic characteristics of branch retinal and hemicentral retinal vein occlusion. Ophthalmology. 2010 Apr; 117(4):780-4. Prasad PS, Oliver SC, Coffee RE, Hubschman JP, Schwartz SD. PMID: 20045570.
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    132. Peripheral vessel leakage (PVL): a new angiographic finding in diabetic retinopathy identified with ultra wide-field fluorescein angiography. Semin Ophthalmol. 2010 Jan-Mar; 25(1-2):27-33. Oliver SC, Schwartz SD. PMID: 20507194.
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    133. Experimental model of intravitreal injection techniques. Retina. 2010 Jan; 30(1):167-73. Hubschman JP, Coffee RE, Bourges JL, Yu F, Schwartz SD. PMID: 19779317.
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    134. Retinal vascular patterns after operative repair of aortic isthmic coarctation. Am J Cardiol. 2010 Feb 01; 105(3):408-10. Shamsa K, Perloff JK, Lee E, Wirthlin RS, Tsui I, Schwartz SD. PMID: 20102958.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    135. Approximate inclusion of quantum effects in transition path sampling. J Chem Phys. 2009 Dec 14; 131(22):224111. Antoniou D, Schwartz SD. PMID: 20001028; PMCID: PMC2802259.
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    136. Retinal vascular patterns in adults with cyanotic congenital heart disease. Semin Ophthalmol. 2009 Nov-Dec; 24(6):262-5. Tsui I, Shamsa K, Perloff JK, Lee E, Wirthlin RS, Schwartz SD. PMID: 19954382.
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    137. Effect of cutting phases on flow rate in 20-, 23-, and 25-gauge vitreous cutters. Retina. 2009 Oct; 29(9):1289-93. Hubschman JP, Bourges JL, Tsui I, Reddy S, Yu F, Schwartz SD. PMID: 19730161.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    138. Enzymatic transition states and dynamic motion in barrier crossing. Nat Chem Biol. 2009 Aug; 5(8):551-8. Schwartz SD, Schramm VL. PMID: 19620996; PMCID: PMC2859820.
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    139. Endophthalmitis after pars plana vitrectomy a 20- and 25-gauge comparison. Ophthalmology. 2009 Jul; 116(7):1360-5. Hu AY, Bourges JL, Shah SP, Gupta A, Gonzales CR, Oliver SC, Schwartz SD. PMID: 19576499.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    140. Age-related macular degeneration: current treatments. Clin Ophthalmol. 2009; 3:155-66. Hubschman JP, Reddy S, Schwartz SD. PMID: 19668560; PMCID: PMC2709020.
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    141. Age-related macular degeneration: experimental and emerging treatments. Clin Ophthalmol. 2009; 3:167-74. Hubschman JP, Reddy S, Schwartz SD. PMID: 19668561; PMCID: PMC2709010.
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    142. Submacular combination treatment for management of acute, massive submacular hemorrhage in age-related macular degeneration. Ophthalmic Surg Lasers Imaging. 2009 May-Jun; 40(3):308-15. Shah SP, Hubschman JP, Gonzales CR, Schwartz SD. PMID: 19485299.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    143. The stochastic separatrix and the reaction coordinate for complex systems. J Chem Phys. 2009 Apr 21; 130(15):151103. Antoniou D, Schwartz SD. PMID: 19388729; PMCID: PMC2719472.
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    144. Modeling vibrational resonance in linear hydrocarbon chain with a mixed quantum-classical method. J Chem Phys. 2009 Apr 07; 130(13):134110. Gelman D, Schwartz SD. PMID: 19355720.
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    145. Comparison studies of the human heart and Bacillus stearothermophilus lactate dehydrogreanse by transition path sampling. J Phys Chem A. 2009 Mar 12; 113(10):1892-7. Quaytman SL, Schwartz SD. PMID: 19053545; PMCID: PMC3175424.
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    146. Ultra widefield imaging of peripheral exudative hemorrhagic chorioretinopathy. Semin Ophthalmol. 2009 Jan-Feb; 24(1):25-8. Tsui I, Jain A, Shah S, Schwartz SD, McCannel TA. PMID: 19241288.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    147. The use of ultra wide field fluorescein angiography in evaluation and management of uveitis. Semin Ophthalmol. 2009 Jan-Feb; 24(1):19-24. Kaines A, Tsui I, Sarraf D, Schwartz S. PMID: 19241287.
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    148. Ultrawide angle angiography for the detection and management of diabetic retinopathy. Int Ophthalmol Clin. 2009; 49(2):53-9. Kaines A, Oliver S, Reddy S, Schwartz SD. PMID: 19349786.
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    149. Ultra Wide Field Fluorescein Angiography Guided Targeted Retinal Photocoagulation (TRP). Semin Ophthalmol. 2009 Jan-Feb; 24(1):9-14. Reddy S, Hu A, Schwartz SD. PMID: 19241285.
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    150. Patterns of periphlebitis in intermediate uveitis using ultra wide field fluorescein angiography. Semin Ophthalmol. 2009 Jan-Feb; 24(1):29-33. Tsui I, Kaines A, Schwartz S. PMID: 19241289.
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    151. Atomic detail of chemical transformation at the transition state of an enzymatic reaction. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16543-8. Saen-Oon S, Quaytman-Machleder S, Schramm VL, Schwartz SD. PMID: 18946041; PMCID: PMC2575456.
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    152. Tunneling dynamics with a mixed quantum-classical method: quantum corrected propagator combined with frozen Gaussian wave packets. J Chem Phys. 2008 Jul 14; 129(2):024504. Gelman D, Schwartz SD. PMID: 18624535.
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    153. Ultrawide angle fluorescein angiographic imaging: a comparison to conventional digital acquisition systems. Ophthalmic Surg Lasers Imaging. 2008 Jul-Aug; 39(4):304-11. Friberg TR, Gupta A, Yu J, Huang L, Suner I, Puliafito CA, Schwartz SD. PMID: 18717436.
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    154. Pediatric rhegmatogenous retinal detachment: clinical features and surgical outcomes. Retina. 2008 Jun; 28(6):847-52. Gonzales CR, Singh S, Yu F, Kreiger AE, Gupta A, Schwartz SD. PMID: 18536601.
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    155. Association of systemic risk factors with the progression of laser-treated retinopathy of prematurity to retinal detachment. Retina. 2008 Mar; 28(3 Suppl):S58-64. Bourla DH, Gonzales CR, Valijan S, Yu F, Mango CW, Schwartz SD. PMID: 18317347.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    156. Tryptophan-free human PNP reveals catalytic site interactions. Biochemistry. 2008 Mar 11; 47(10):3202-15. Ghanem M, Saen-oon S, Zhadin N, Wing C, Cahill SM, Schwartz SD, Callender R, Schramm VL. PMID: 18269249.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    157. 20-, 23-, and 25-gauge vitreous cutters: performance and characteristics evaluation. Retina. 2008 Feb; 28(2):249-57. Hubschman JP, Gupta A, Bourla DH, Culjat M, Yu F, Schwartz SD. PMID: 18301030.
      View in: PubMed   Mentions: 16     Fields:    
    158. Remote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase. Biophys J. 2008 May 15; 94(10):4078-88. Saen-Oon S, Ghanem M, Schramm VL, Schwartz SD. PMID: 18234834; PMCID: PMC2367194.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    159. Transition Path Sampling Study of the Reaction Catalyzed by Purine Nucleoside Phosphorylase. Z Phys Chem (N F). 2008; 222(8-9):1359-1374. Saen-Oon S, Schramm VL, Schwartz SD. PMID: 20664707; PMCID: PMC2909608.
      View in: PubMed   Mentions: 14  
    160. Feasibility study of intraocular robotic surgery with the da Vinci surgical system. Retina. 2008 Jan; 28(1):154-8. Bourla DH, Hubschman JP, Culjat M, Tsirbas A, Gupta A, Schwartz SD. PMID: 18185154.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    161. Computational Characterization of Mutations in Cardiac Troponin T Known to Cause Familial Hypertrophic Cardiomyopathy. J Theor Comput Chem. 2007 Sep; 6(3):413. Guinto PJ, Manning EP, Schwartz SD, Tardiff JC. PMID: 26500385; PMCID: PMC4617307.
      View in: PubMed   Mentions: 17  
    162. Reaction coordinate of an enzymatic reaction revealed by transition path sampling. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12253-8. Quaytman SL, Schwartz SD. PMID: 17640885; PMCID: PMC1941458.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    163. Suprachoroidal hemorrhage as an intraoperative complication of 25-gauge pars plana vitrectomy. Semin Ophthalmol. 2007 Jul-Sep; 22(3):197-9. Kapamajian M, Gonzales CR, Gupta A, Schwartz SD. PMID: 17763245.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    164. Peripheral retinopathy and maculopathy in high-dose tamoxifen therapy. Am J Ophthalmol. 2007 Jul; 144(1):126-8. Bourla DH, Sarraf D, Schwartz SD. PMID: 17601434.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    165. The slower the better: on the instability of gas jets in a model of pneumatic retinopexy. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2734-7. Bourla DH, Gupta A, Hubschman JP, Bourla N, Yu F, Schwartz SD. PMID: 17525206.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    166. Risk for eye splash injury during administration of intraocular injections: a study of retina specialists and fellows. Retina. 2007 Jun; 27(5):609-12. Bourla DH, Wirthlin RS, Bourla N, Gupta A, Stanescu-Segall D, Schwartz SD, Axer-Siegel R. PMID: 17558324.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    167. New mixed quantumsemiclassical propagation method. J Chem Phys. 2007 May 14; 126(18):184107. Antoniou D, Gelman D, Schwartz SD. PMID: 17508792.
      View in: PubMed   Mentions: 1     Fields:    
    168. Ligand binding and protein dynamics in lactate dehydrogenase. Biophys J. 2007 Sep 01; 93(5):1474-83. Pineda JR, Callender R, Schwartz SD. PMID: 17483170; PMCID: PMC1948035.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    169. Familial exudative vitreoretinopathy and macular hole exhibited in same individual. Semin Ophthalmol. 2007 Apr-Jun; 22(2):85-6. Khwarg JW, Bourla D, Gonzales CA, Schwartz SD. PMID: 17564927.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    170. Intravitreous vascular endothelial growth factor (VEGF) inhibitor therapy for tamoxifen induced macular edema. Semin Ophthalmol. 2007 Apr-Jun; 22(2):87-8. Bourla DH, Gonzales CR, Mango CW, Moral JN, Wirthlin RS, Schwartz SD. PMID: 17564928.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    171. Outcomes of vitrectomy with inferior retinectomy in patients with recurrent rhegmatogenous retinal detachments and proliferative vitreoretinopathy. Ophthalmology. 2006 Nov; 113(11):2041-7. Quiram PA, Gonzales CR, Hu W, Gupta A, Yoshizumi MO, Kreiger AE, Schwartz SD. PMID: 16952397.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    172. 25-Gauge pars plicata vitrectomy for stage 4 and 5 retinopathy of prematurity. Retina. 2006 Sep; 26(7 Suppl):S42-6. Gonzales CR, Boshra J, Schwartz SD. PMID: 16946678.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    173. Computational and theoretical methods to explore the relation between enzyme dynamics and catalysis. Chem Rev. 2006 Aug; 106(8):3170-87. Antoniou D, Basner J, Núñez S, Schwartz SD. PMID: 16895323.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    174. Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide. Am J Ophthalmol. 2006 Mar; 141(3):580-2. Quiram PA, Gonzales CR, Schwartz SD. PMID: 16490518.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    175. Insight into catalytically relevant correlated motions in human purine nucleoside phosphorylase. J Phys Chem A. 2006 Jan 19; 110(2):463-72. Núñez S, Wing C, Antoniou D, Schramm VL, Schwartz SD. PMID: 16405318.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    176. Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18219-24. Ertz-Berger BR, He H, Dowell C, Factor SM, Haim TE, Nunez S, Schwartz SD, Ingwall JS, Tardiff JC. PMID: 16326803; PMCID: PMC1298915.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    177. Diagnostic & therapeutic challenges. Retina. 2005 Dec; 25(8):1085-8. Yang SS, Ferrone PJ, Gonzales CR, Schwartz SD. PMID: 16340539.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    178. How enzyme dynamics helps catalyze a reaction in atomic detail: a transition path sampling study. J Am Chem Soc. 2005 Oct 12; 127(40):13822-31. Basner JE, Schwartz SD. PMID: 16201803.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
    179. A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology. 2005 Oct; 112(10):1747-57. Cunningham ET, Adamis AP, Altaweel M, Aiello LP, Bressler NM, D'Amico DJ, Goldbaum M, Guyer DR, Katz B, Patel M, Schwartz SD, Macugen Diabetic Retinopathy Study Group. PMID: 16154196.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansCTClinical Trials
    180. Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration. Ophthalmology. 2005 Jun; 112(6):1048-53. Rosenfeld PJ, Schwartz SD, Blumenkranz MS, Miller JW, Haller JA, Reimann JD, Greene WL, Shams N. PMID: 15885778.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCTClinical Trials
    181. Promoting vibrations in human purine nucleoside phosphorylase. A molecular dynamics and hybrid quantum mechanical/molecular mechanical study. J Am Chem Soc. 2004 Dec 08; 126(48):15720-9. Núñez S, Antoniou D, Schramm VL, Schwartz SD. PMID: 15571394.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    182. Surgery for subfoveal choroidal neovascularization in age-related macular degeneration: ophthalmic findings: SST report no. 11. Ophthalmology. 2004 Nov; 111(11):1967-80. Hawkins BS, Bressler NM, Miskala PH, Bressler SB, Holekamp NM, Marsh MJ, Redford M, Schwartz SD, Sternberg P, Thomas MA, Wilson DJ, Submacular Surgery Trials (SST) Research Group. PMID: 15522362; PMCID: PMC1256024.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCTClinical Trials
    183. Transition path sampling study of classical rate-promoting vibrations. J Chem Phys. 2004 Oct 01; 121(13):6442-7. Antoniou D, Abolfath MR, Schwartz SD. PMID: 15446943.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    184. Rate-promoting vibrations and coupled hydrogen-electron transfer reactions in the condensed phase: a model for enzymatic catalysis. J Chem Phys. 2004 Apr 22; 120(16):7755-60. Mincer JS, Schwartz SD. PMID: 15267689.
      View in: PubMed   Mentions: 18     Fields:    
    185. The fellow eye of patients with rhegmatogenous retinal detachment. Ophthalmology. 2004 Mar; 111(3):518-21. Gonzales CR, Gupta A, Schwartz SD, Kreiger AE. PMID: 15019329.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    186. Protein promoting vibrations in enzyme catalysis--a conserved evolutionary motif. J Proteome Res. 2003 Jul-Aug; 2(4):437-9. Mincer JS, Schwartz SD. PMID: 12945535.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    187. Bilateral choroidal folds and optic neuropathy: a variant of the crowded disk syndrome? Ophthalmology. 2003 May; 110(5):1047-52. Sarraf D, Schwartz SD. PMID: 12750112.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    188. Inadvertent skip areas in treatment of zone 1 retinopathy of prematurity. Retina. 2003 Feb; 23(1):128-31. Shaikh S, Capone A, Schwartz SD, Gonzales C, Trese MT, ROP Photographic Screening Trial (Photo-ROP) Study Group. PMID: 12652254.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    189. Barrier passage and protein dynamics in enzymatically catalyzed reactions. Eur J Biochem. 2002 Jul; 269(13):3103-12. Antoniou D, Caratzoulas S, Kalyanaraman C, Mincer JS, Schwartz SD. PMID: 12084050.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    190. Identification of a protein-promoting vibration in the reaction catalyzed by horse liver alcohol dehydrogenase. J Am Chem Soc. 2002 Apr 03; 124(13):3270-6. Caratzoulas S, Mincer JS, Schwartz SD. PMID: 11916410.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
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