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Ganz Tomas

Title(s)Center Associate Director, CAI
SchoolUC Braid
Phone310-206-8622
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    Other Positions
    Title(s)Distinguished Professor, Medicine

    Title(s)Distinguished Professor, Pathology and Laboratory Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    Bioiron 2013: From basic science to medicine
    NIH/NIDDK R13DK098971Apr 1, 2013 - Mar 31, 2014
    Role: Principal Investigator
    Bioiron 2011: From basic science to medicine
    NIH/NIDDK R13DK092102May 1, 2011 - Apr 30, 2012
    Role: Principal Investigator
    Activin signaling in normal and disordered erythropoiesis
    NIH/NIDDK R01DK090554Sep 30, 2010 - Jan 31, 2022
    Role: Co-Principal Investigator
    THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    NIH/NHLBI R01HL091531Jun 15, 2007 - May 31, 2011
    Role: Principal Investigator
    The role of hemojuvelin in the regulation of iron metabolism
    NIH/NIDDK R21DK073226Feb 15, 2006 - Jan 31, 2008
    Role: Principal Investigator
    Pulmonary and Critical Care Medicine Training Program
    NIH/NHLBI T32HL072752Jul 1, 2003 - Apr 30, 2019
    Role: Co-Principal Investigator
    The role of erythroferrone in iron homeostasis and in iron-loading anemias
    NIH/NIDDK R01DK065029Jul 1, 2003 - Jun 30, 2018
    Role: Principal Investigator
    NASAL CARRIAGE OF STAPHYLOCOCCUS AUREUS
    NIH/NIAID R21AI048167Sep 30, 2000 - Sep 29, 2003
    Role: Principal Investigator
    INNATE HOST DEFENSE IN THE HUMAN VAGINA
    NIH/NIAID R01AI046514Sep 15, 2000 - Aug 31, 2005
    Role: Principal Investigator
    CONFERENCE ANTIMICROBIAL PEPTIDES OF HIGHER EUKARYOTES
    NIH/NIAID R13AI040440Mar 1, 1997 - Feb 28, 1998
    Role: Principal Investigator
    BETA-DEFENSINS IN THE FEMALE GENITAL TRACT AND KIDNEYS
    NIH/NIAID R01AI040248Aug 1, 1996 - Jul 31, 2001
    Role: Principal Investigator
    IMMUNOPOTENTIATION BY TRANSGENIC ANTIMICROBIAL PEPTIDES
    NIH/NIAID R01AI038567Sep 30, 1995 - Jul 31, 1998
    Role: Principal Investigator
    Human Defensins in Phagocytes and Epithelia
    NIH/NHLBI R01HL046809Jan 1, 1993 - Jun 30, 2005
    Role: Principal Investigator
    CATIONIC PEPTIDES AND THE LUNG
    NIH/NHLBI R01HL035640Dec 1, 1985 - Jun 30, 1995
    Role: Principal Investigator
    MICROBICIDAL MECHANISMS AGAINST PNEUMOCYSTIS CARINII
    NIH/NIAID R01AI021931Sep 30, 1984 - Aug 31, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sangkhae V, Fisher AL, Wong S, Koenig MD, Tussing-Humphreys L, Chu A, Lelic M, Ganz T, Nemeth E. Effects of maternal iron status on placental and fetal iron homeostasis. J Clin Invest. 2019 Oct 29. PMID: 31661462.
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    2. Ganz T. Anemia of Inflammation. N Engl J Med. 2019 Sep 19; 381(12):1148-1157. PMID: 31532961.
      View in: PubMed
    3. Bondu S, Alary AS, Lefèvre C, Houy A, Jung G, Lefebvre T, Rombaut D, Boussaid I, Bousta A, Guillonneau F, Perrier P, Alsafadi S, Wassef M, Margueron R, Rousseau A, Droin N, Cagnard N, Kaltenbach S, Winter S, Kubasch AS, Bouscary D, Santini V, Toma A, Hunault M, Stamatoullas A, Gyan E, Cluzeau T, Platzbecker U, Adès L, Puy H, Stern MH, Karim Z, Mayeux P, Nemeth E, Park S, Ganz T, Kautz L, Kosmider O, Fontenay M. A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome. Sci Transl Med. 2019 Jul 10; 11(500). PMID: 31292266.
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    4. Pergola PE, Fishbane S, Ganz T. Novel Oral Iron Therapies for Iron Deficiency Anemia in Chronic Kidney Disease. Adv Chronic Kidney Dis. 2019 Jul; 26(4):272-291. PMID: 31477258.
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    5. Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, Okreglicka K, Hültner L, Schneider M, Ladinig C, Kuklik-Roos C, Mysliwietz J, Janik D, Neff F, Rathkolb B, Hrabé de Angelis M, Buske C, da Silva AR, Muedder K, Conrad M, Ganz T, Kopf M, Muckenthaler MU, Bornkamm GW. Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis. Haematologica. 2019 Jun 27. PMID: 31248967.
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    6. Ganz T. The Discovery of the Iron-Regulatory Hormone Hepcidin. Clin Chem. 2019 Oct; 65(10):1330-1331. PMID: 31235538.
      View in: PubMed
    7. Ganz T, Bino A, Salusky IB. Mechanism of Action and Clinical Attributes of Auryxia® (Ferric Citrate). Drugs. 2019 Jun; 79(9):957-968. PMID: 31134521.
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    8. Ganz T, Ganz P. William Ganz and His Legacy. Ann Intern Med. 2019 May 21; 170(10):734-735. PMID: 31108522.
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    9. Honda H, Hosaka N, Ganz T, Shibata T. Iron Metabolism in Chronic Kidney Disease Patients. Contrib Nephrol. 2019; 198:103-111. PMID: 30991401.
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    10. Liu J, Liu W, Liu Y, Miao Y, Guo Y, Song H, Wang F, Zhou H, Ganz T, Yan B, Liu S. New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and ß-thalassemia. Haematologica. 2019 Sep; 104(9):1768-1781. PMID: 30792208.
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    11. Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation. Radiat Res. 2019 04; 191(4):323-334. PMID: 30730284.
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    12. Chen Q, Yang Y, Hou J, Shu Q, Yin Y, Fu W, Han F, Hou T, Zeng C, Nemeth E, Linzmeier R, Ganz T, Fang X. Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3161-3170. PMID: 30718392.
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    13. Guo Y, Zhang N, Zhang D, Ren Q, Ganz T, Liu S, Nemeth E. Iron homeostasis in pregnancy and spontaneous abortion. Am J Hematol. 2019 Feb; 94(2):184-188. PMID: 30394565.
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    14. Ganz T. Erythrocytes and erythroblasts give up iron. Blood. 2018 11 08; 132(19):2004-2005. PMID: 30409893.
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    15. Weiss G, Ganz T, Goodnough LT. Anemia of inflammation. Blood. 2019 01 03; 133(1):40-50. PMID: 30401705.
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    16. Ganz T. Erythropoietin and iron-a conflicted alliance? Kidney Int. 2018 11; 94(5):851-853. PMID: 30348300.
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    17. Gagliano-Jucá T, Pencina KM, Ganz T, Travison TG, Kantoff PW, Nguyen PL, Taplin ME, Kibel AS, Li Z, Huang G, Edwards RR, Nemeth E, Basaria S. Mechanisms responsible for reduced erythropoiesis during androgen deprivation therapy in men with prostate cancer. Am J Physiol Endocrinol Metab. 2018 12 01; 315(6):E1185-E1193. PMID: 30325657.
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    18. Coffey R, Sardo U, Kautz L, Gabayan V, Nemeth E, Ganz T. Erythroferrone is not required for the glucoregulatory and hematologic effects of chronic erythropoietin treatment in mice. Physiol Rep. 2018 09; 6(19):e13890. PMID: 30315639.
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    19. Deshpande CN, Ruwe TA, Shawki A, Xin V, Vieth KR, Valore EV, Qiao B, Ganz T, Nemeth E, Mackenzie B, Jormakka M. Calcium is an essential cofactor for metal efflux by the ferroportin transporter family. Nat Commun. 2018 08 06; 9(1):3075. PMID: 30082682.
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    20. Ginzburg YZ, Feola M, Zimran E, Varkonyi J, Ganz T, Hoffman R. Dysregulated iron metabolism in polycythemia vera: etiology and consequences. Leukemia. 2018 10; 32(10):2105-2116. PMID: 30042411.
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    21. Hanudel MR, Eisenga MF, Rappaport M, Chua K, Qiao B, Jung G, Gabayan V, Gales B, Ramos G, de Jong MA, van Zanden JJ, de Borst MH, Bakker SJL, Nemeth E, Salusky IB, Gaillard CAJM, Ganz T. Effects of erythropoietin on fibroblast growth factor 23 in mice and humans. Nephrol Dial Transplant. 2018 Jul 10. PMID: 30007314.
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    22. Ganz T. Erythropoietic regulators of iron metabolism. Free Radic Biol Med. 2019 03; 133:69-74. PMID: 29981834.
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    23. Stefanova D, Raychev A, Deville J, Humphries R, Campeau S, Ruchala P, Nemeth E, Ganz T, Bulut Y. Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients. Infect Immun. 2018 07; 86(7). PMID: 29735522.
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    24. Cox HD, Miller GD, Lai A, Cushman D, Ganz T, Eichner D. Evaluation of serum markers for improved detection of autologous blood transfusions. Haematologica. 2018 10; 103(10):e443-e445. PMID: 29674501.
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    25. Stasiak IM, Smith DA, Ganz T, Crawshaw GJ, Hammermueller JD, Bienzle D, Lillie BN. Iron storage disease (hemochromatosis) and hepcidin response to iron load in two species of pteropodid fruit bats relative to the common vampire bat. J Comp Physiol B. 2018 07; 188(4):683-694. PMID: 29594459.
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    26. Coffey R, Ganz T. Erythroferrone: An Erythroid Regulator of Hepcidin and Iron Metabolism. Hemasphere. 2018 Mar-Apr; 2(2):e35. PMID: 31723763.
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    27. Adams P, Altes A, Brissot P, Butzeck B, Cabantchik I, Cançado R, Distante S, Evans P, Evans R, Ganz T, Girelli D, Hultcrantz R, McLaren G, Marris B, Milman N, Nemeth E, Nielsen P, Pineau B, Piperno A, Porto G, Prince D, Ryan J, Sanchez M, Santos P, Swinkels D, Teixeira E, Toska K, Vanclooster A, White D. Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype. Hepatol Int. 2018 Mar; 12(2):83-86. PMID: 29589198.
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    28. Meznarich JA, Draper L, Christensen RD, Yaish HM, Luem ND, Pysher TJ, Jung G, Nemeth E, Ganz T, Ward DM. Fetal presentation of congenital dyserythropoietic anemia type 1 with novel compound heterozygous CDAN1 mutations. Blood Cells Mol Dis. 2018 07; 71:63-66. PMID: 29599085.
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    29. Wish JB, Aronoff GR, Bacon BR, Brugnara C, Eckardt KU, Ganz T, Macdougall IC, Núñez J, Perahia AJ, Wood JC. Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell? Am J Nephrol. 2018; 47(2):72-83. PMID: 29439253.
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    30. Hanudel MR, Rappaport M, Chua K, Gabayan V, Qiao B, Jung G, Salusky IB, Ganz T, Nemeth E. Levels of the erythropoietin-responsive hormone erythroferrone in mice and humans with chronic kidney disease. Haematologica. 2018 04; 103(4):e141-e142. PMID: 29419424.
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    31. Rzymski P, Ganz T. Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet". Biol Trace Elem Res. 2018 09; 185(1):252-254. PMID: 29322429.
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    32. Ganz T. Correction to: Iron and infection. Int J Hematol. 2018 01; 107(1):122. PMID: 29197980.
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    33. Aschemeyer S, Qiao B, Stefanova D, Valore EV, Sek AC, Ruwe TA, Vieth KR, Jung G, Casu C, Rivella S, Jormakka M, Mackenzie B, Ganz T, Nemeth E. Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin. Blood. 2018 02 22; 131(8):899-910. PMID: 29237594.
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    34. Chow JKL, Ganz T, Ruthazer R, Simpson MA, Pomfret EA, Gordon FD, Westerman ME, Snydman DR. Iron-related markers are associated with infection after liver transplantation. Liver Transpl. 2017 12; 23(12):1541-1552. PMID: 28703464.
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    35. Ganz T. Iron and infection. Int J Hematol. 2018 Jan; 107(1):7-15. PMID: 29147843.
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    36. Khorramian E, Fung E, Chua K, Gabayan V, Ganz T, Nemeth E, Kim A. In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively than Iron and Erythropoietin Treatment. Shock. 2017 10; 48(4):490-497. PMID: 28452907.
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    37. Matte A, De Falco L, Federti E, Cozzi A, Iolascon A, Levi S, Mohandas N, Zamo A, Bruno M, Lebouef C, Janin A, Siciliano A, Ganz T, Federico G, Carlomagno F, Mueller S, Silva I, Carbone C, Melisi D, Kim DW, Choi SY, De Franceschi L. Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis. Antioxid Redox Signal. 2018 Jan 01; 28(1):1-14. PMID: 28793778.
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    38. Clinkenbeard EL, Hanudel MR, Stayrook KR, Appaiah HN, Farrow EG, Cass TA, Summers LJ, Ip CS, Hum JM, Thomas JC, Ivan M, Richine BM, Chan RJ, Clemens TL, Schipani E, Sabbagh Y, Xu L, Srour EF, Alvarez MB, Kacena MA, Salusky IB, Ganz T, Nemeth E, White KE. Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow. Haematologica. 2017 11; 102(11):e427-e430. PMID: 28818868.
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    39. Vos JM, Tsakmaklis N, Patterson CJ, Meid K, Castillo JJ, Brodsky P, Ganz T, Pals ST, Kersten MJ, Xu L, Yang G, Treon SP, Hunter ZR. CXCL13 levels are elevated in patients with Waldenström macroglobulinemia, and are predictive of major response to ibrutinib. Haematologica. 2017 11; 102(11):e452-e455. PMID: 28798070.
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    40. McLachlan S, Page KE, Lee SM, Loguinov A, Valore E, Hui ST, Jung G, Zhou J, Lusis AJ, Fuqua B, Ganz T, Nemeth E, Vulpe CD. Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 01; 313(5):G511-G523. PMID: 28798083.
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    41. Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, Vince DG, Watts L. NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges. Nat Rev Drug Discov. 2017 10; 16(10):663-664. PMID: 28775338.
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    42. Ganz T, Jung G, Naeim A, Ginzburg Y, Pakbaz Z, Walter PB, Kautz L, Nemeth E. Immunoassay for human serum erythroferrone. Blood. 2017 09 07; 130(10):1243-1246. PMID: 28739636.
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    43. Coffey R, Ganz T. Iron homeostasis: An anthropocentric perspective. J Biol Chem. 2017 08 04; 292(31):12727-12734. PMID: 28615456.
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    44. Ganz T. Does Pathological Iron Overload Impair the Function of Human Lungs? EBioMedicine. 2017 06; 20:13-14. PMID: 28545989.
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    45. Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E. Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood. 2017 07 20; 130(3):245-257. PMID: 28465342.
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    46. Michels KR, Zhang Z, Bettina AM, Cagnina RE, Stefanova D, Burdick MD, Vaulont S, Nemeth E, Ganz T, Mehrad B. Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia. JCI Insight. 2017 03 23; 2(6):e92002. PMID: 28352667.
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    47. Preziosi ME, Singh S, Valore EV, Jung G, Popovic B, Poddar M, Nagarajan S, Ganz T, Monga SP. Mice lacking liver-specific ß-catenin develop steatohepatitis and fibrosis after iron overload. J Hepatol. 2017 08; 67(2):360-369. PMID: 28341391.
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    48. Aschemeyer S, Gabayan V, Ganz T, Nemeth E, Kautz L. Erythroferrone and matriptase-2 independently regulate hepcidin expression. Am J Hematol. 2017 05; 92(5):E61-E63. PMID: 28187515.
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    49. Hanudel MR, Rappaport M, Gabayan V, Jung G, Salusky IB, Nemeth E, Ganz T, Zaritsky J. Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model. Haematologica. 2017 03; 102(3):e85-e88. PMID: 27884972.
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    50. Hanudel MR, Chua K, Rappaport M, Gabayan V, Valore E, Goltzman D, Ganz T, Nemeth E, Salusky IB. Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild-type and hepcidin knockout mice. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1369-F1377. PMID: 27733366.
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    51. Ganz T. Macrophages and Iron Metabolism. Microbiol Spectr. 2016 10; 4(5). PMID: 27763254.
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    52. Latour C, Wlodarczyk MF, Jung G, Gineste A, Blanchard N, Ganz T, Roth MP, Coppin H, Kautz L. Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia. Haematologica. 2017 01; 102(1):60-68. PMID: 27658439.
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    53. Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S. Minihepcidin peptides as disease modifiers in mice affected by ß-thalassemia and polycythemia vera. Blood. 2016 07 14; 128(2):265-76. PMID: 27154187.
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    54. Ganz T, Nemeth E. Iron Balance and the Role of Hepcidin in Chronic Kidney Disease. Semin Nephrol. 2016 03; 36(2):87-93. PMID: 27236128.
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    55. Kalinowski DS, Stefani C, Toyokuni S, Ganz T, Anderson GJ, Subramaniam NV, Trinder D, Olynyk JK, Chua A, Jansson PJ, Sahni S, Lane DJ, Merlot AM, Kovacevic Z, Huang ML, Lee CS, Richardson DR. Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochim Biophys Acta. 2016 Apr; 1863(4):727-48. PMID: 26844773.
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    56. Ganz T. Hepcidin. Rinsho Ketsueki. 2016; 57(10):1913-1917. PMID: 27725588.
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    57. Drakesmith H, Nemeth E, Ganz T. Ironing out Ferroportin. Cell Metab. 2015 Nov 03; 22(5):777-87. PMID: 26437604.
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    58. Kim A, Fung E, Parikh SG, Gabayan V, Nemeth E, Ganz T. Isocitrate treatment of acute anemia of inflammation in a mouse model. Blood Cells Mol Dis. 2016 Jan; 56(1):31-6. PMID: 26603720.
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    59. Michels K, Nemeth E, Ganz T, Mehrad B. Hepcidin and Host Defense against Infectious Diseases. PLoS Pathog. 2015 Aug; 11(8):e1004998. PMID: 26291319.
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    60. Kautz L, Jung G, Du X, Gabayan V, Chapman J, Nasoff M, Nemeth E, Ganz T. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of ß-thalassemia. Blood. 2015 Oct 22; 126(17):2031-7. PMID: 26276665.
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    61. Ganz T, Nemeth E. Iron homeostasis in host defence and inflammation. Nat Rev Immunol. 2015 Aug; 15(8):500-10. PMID: 26160612.
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    62. Keel SB, Doty R, Liu L, Nemeth E, Cherian S, Ganz T, Abkowitz JL. Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver. Exp Hematol. 2015 Jun; 43(6):469-78.e6. PMID: 25782630.
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    63. Chua K, Fung E, Micewicz ED, Ganz T, Nemeth E, Ruchala P. Small cyclic agonists of iron regulatory hormone hepcidin. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4961-4969. PMID: 25813158.
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    64. Arezes J, Jung G, Gabayan V, Valore E, Ruchala P, Gulig PA, Ganz T, Nemeth E, Bulut Y. Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus. Cell Host Microbe. 2015 Jan 14; 17(1):47-57. PMID: 25590758.
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    65. Fung E, Chua K, Ganz T, Nemeth E, Ruchala P. Thiol-derivatized minihepcidins retain biological activity. Bioorg Med Chem Lett. 2015 Feb 15; 25(4):763-6. PMID: 25599838.
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    66. Ganz T. Hepcidin and the global burden of iron deficiency. Clin Chem. 2015 Apr; 61(4):577-8. PMID: 25492087.
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    67. Gutschow P, Schmidt PJ, Han H, Ostland V, Bartnikas TB, Pettiglio MA, Herrera C, Butler JS, Nemeth E, Ganz T, Fleming MD, Westerman M. A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis. Haematologica. 2015 Feb; 100(2):167-77. PMID: 25425686.
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    68. Macciò A, Madeddu C, Gramignano G, Mulas C, Tanca L, Cherchi MC, Floris C, Omoto I, Barracca A, Ganz T. The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study. Haematologica. 2015 Jan; 100(1):124-32. PMID: 25239265.
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    69. Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014 Oct 16; 124(16):2569-74. PMID: 25193872.
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    70. Zhang S, Chen Y, Guo W, Yuan L, Zhang D, Xu Y, Nemeth E, Ganz T, Liu S. Disordered hepcidin-ferroportin signaling promotes breast cancer growth. Cell Signal. 2014 Nov; 26(11):2539-50. PMID: 25093806.
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    71. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014 Jul; 46(7):678-84. PMID: 24880340.
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    72. Nemeth E, Ganz T. Anemia of inflammation. Hematol Oncol Clin North Am. 2014 Aug; 28(4):671-81, vi. PMID: 25064707.
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    73. Kim A, Rivera S, Shprung D, Limbrick D, Gabayan V, Nemeth E, Ganz T. Mouse models of anemia of cancer. PLoS One. 2014; 9(3):e93283. PMID: 24681760.
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    74. Kim A, Fung E, Parikh SG, Valore EV, Gabayan V, Nemeth E, Ganz T. A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood. 2014 Feb 20; 123(8):1129-36. PMID: 24357728.
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    75. Latour C, Kautz L, Besson-Fournier C, Island ML, Canonne-Hergaux F, Loréal O, Ganz T, Coppin H, Roth MP. Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology. 2014 Feb; 59(2):683-94. PMID: 23907767.
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    76. Kautz L, Gabayan V, Wang X, Wu J, Onwuzurike J, Jung G, Qiao B, Lusis AJ, Ganz T, Nemeth E. Testing the iron hypothesis in a mouse model of atherosclerosis. Cell Rep. 2013 Dec 12; 5(5):1436-42. PMID: 24316081.
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    77. Mitchell CJ, Shawki A, Ganz T, Nemeth E, Mackenzie B. Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc. Am J Physiol Cell Physiol. 2014 Mar 01; 306(5):C450-9. PMID: 24304836.
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    78. Rodriguez R, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infect Immun. 2014 Feb; 82(2):745-52. PMID: 24478088.
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    79. Ganz T. Systemic iron homeostasis. Physiol Rev. 2013 Oct; 93(4):1721-41. PMID: 24137020.
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    80. Clark RJ, Preza GC, Tan CC, van Dijk JW, Fung E, Nemeth E, Ganz T, Craik DJ. Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers. 2013 Sep; 100(5):519-26. PMID: 23897622.
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    81. McCranor BJ, Langdon JM, Prince OD, Femnou LK, Berger AE, Cheadle C, Civin CI, Kim A, Rivera S, Ganz T, Vaulont S, Xue QL, Walston JD, Roy CN. Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age. Haematologica. 2013 Oct; 98(10):1633-40. PMID: 23996485.
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    82. Preza GC, Pinon R, Ganz T, Nemeth E. Cellular catabolism of the iron-regulatory peptide hormone hepcidin. PLoS One. 2013; 8(3):e58934. PMID: 23536837.
      View in: PubMed
    83. Mast AE, Schlumpf KS, Wright DJ, Johnson B, Glynn SA, Busch MP, Olbina G, Westerman M, Nemeth E, Ganz T. Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy. Haematologica. 2013 Aug; 98(8):1324-30. PMID: 23445875.
      View in: PubMed
    84. Fung E, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E. High-throughput screening of small molecules identifies hepcidin antagonists. Mol Pharmacol. 2013 Mar; 83(3):681-90. PMID: 23292796.
      View in: PubMed
    85. Ganz T. Preface: iron and cancer. Crit Rev Oncog. 2013; 18(5):preceding 391. PMID: 23879592.
      View in: PubMed
    86. Basseri RJ, Nemeth E, Vassilaki ME, Basseri B, Enayati P, Shaye O, Bourikas LA, Ganz T, Papadakis KA. Hepcidin is a key mediator of anemia of inflammation in Crohn's disease. J Crohns Colitis. 2013 Sep; 7(8):e286-91. PMID: 23219355.
      View in: PubMed
    87. Ramos E, Ruchala P, Goodnough JB, Kautz L, Preza GC, Nemeth E, Ganz T. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood. 2012 Nov 01; 120(18):3829-36. PMID: 22990014.
      View in: PubMed
    88. Ganz T, Nemeth E. Iron homeostasis and its disorders in mice and men: potential lessons for rhinos. J Zoo Wildl Med. 2012 Sep; 43(3 Suppl):S19-26. PMID: 23156702.
      View in: PubMed
    89. Ganz T, Goff J, Klasing K, Nemeth E, Roth T. IOD in rhinos--immunity group report: report from the Immunity, Genetics and Toxicology Working Group of the International Workshop on Iron Overload Disorder in Browsing Rhinoceros (February 2011). J Zoo Wildl Med. 2012 Sep; 43(3 Suppl):S117-9. PMID: 23156715.
      View in: PubMed
    90. Goodnough JB, Ramos E, Nemeth E, Ganz T. Inhibition of hepcidin transcription by growth factors. Hepatology. 2012 Jul; 56(1):291-9. PMID: 22278715.
      View in: PubMed
    91. Ross SL, Tran L, Winters A, Lee KJ, Plewa C, Foltz I, King C, Miranda LP, Allen J, Beckman H, Cooke KS, Moody G, Sasu BJ, Nemeth E, Ganz T, Molineux G, Arvedson TL. Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT. Cell Metab. 2012 Jun 06; 15(6):905-17. PMID: 22682226.
      View in: PubMed
    92. Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E. Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab. 2012 Jun 06; 15(6):918-24. PMID: 22682227.
      View in: PubMed
    93. Besson-Fournier C, Latour C, Kautz L, Bertrand J, Ganz T, Roth MP, Coppin H. Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood. 2012 Jul 12; 120(2):431-9. PMID: 22611157.
      View in: PubMed
    94. Ravasi G, Pelucchi S, Trombini P, Mariani R, Tomosugi N, Modignani GL, Pozzi M, Nemeth E, Ganz T, Hayashi H, Barisani D, Piperno A. Hepcidin expression in iron overload diseases is variably modulated by circulating factors. PLoS One. 2012; 7(5):e36425. PMID: 22586470.
      View in: PubMed
    95. Ganz T, Nemeth E. Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harb Perspect Med. 2012 May; 2(5):a011668. PMID: 22553501.
      View in: PubMed
    96. Ganz T. Macrophages and systemic iron homeostasis. J Innate Immun. 2012; 4(5-6):446-53. PMID: 22441209.
      View in: PubMed
    97. Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta. 2012 Sep; 1823(9):1434-43. PMID: 22306005.
      View in: PubMed
    98. Preza GC, Ruchala P, Pinon R, Ramos E, Qiao B, Peralta MA, Sharma S, Waring A, Ganz T, Nemeth E. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest. 2011 Dec; 121(12):4880-8. PMID: 22045566.
      View in: PubMed
    99. Gordeuk VR, Miasnikova GY, Sergueeva AI, Niu X, Nouraie M, Okhotin DJ, Polyakova LA, Ammosova T, Nekhai S, Ganz T, Prchal JT. Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. Blood. 2011 Nov 10; 118(19):5278-82. PMID: 21876117.
      View in: PubMed
    100. Miasnikova GY, Sergueeva AI, Nouraie M, Niu X, Okhotin DJ, Polyakova LA, Ganz T, Prchal JT, Gordeuk VR. The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia. Haematologica. 2011 Sep; 96(9):1371-4. PMID: 21606165.
      View in: PubMed
    101. Pasricha SR, McQuilten Z, Westerman M, Keller A, Nemeth E, Ganz T, Wood E. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica. 2011 Aug; 96(8):1099-105. PMID: 21508121.
      View in: PubMed
    102. Trombini P, Paolini V, Pelucchi S, Mariani R, Nemeth E, Ganz T, Piperno A. Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome. Liver Int. 2011 Aug; 31(7):994-1000. PMID: 21733088.
      View in: PubMed
    103. Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, Roth MP, Nemeth E, Ganz T. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology. 2011 Apr; 53(4):1333-41. PMID: 21480335.
      View in: PubMed
    104. Clark RJ, Tan CC, Preza GC, Nemeth E, Ganz T, Craik DJ. Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chem Biol. 2011 Mar 25; 18(3):336-43. PMID: 21439478.
      View in: PubMed
    105. Ganz T. Hepcidin and iron regulation, 10 years later. Blood. 2011 Apr 28; 117(17):4425-33. PMID: 21346250.
      View in: PubMed
    106. Ghoti H, Fibach E, Westerman M, Gordana O, Ganz T, Rachmilewitz EA. Increased serum hepcidin levels during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndrome. Br J Haematol. 2011 Apr; 153(1):118-20. PMID: 21332711.
      View in: PubMed
    107. Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annu Rev Med. 2011; 62:347-60. PMID: 20887198.
      View in: PubMed
    108. Ganz T, Nemeth E. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematology Am Soc Hematol Educ Program. 2011; 2011:538-42. PMID: 22160086.
      View in: PubMed
    109. Girelli D, Trombini P, Busti F, Campostrini N, Sandri M, Pelucchi S, Westerman M, Ganz T, Nemeth E, Piperno A, Camaschella C. A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis. Haematologica. 2011 Apr; 96(4):500-6. PMID: 21173098.
      View in: PubMed
    110. Piperno A, Galimberti S, Mariani R, Pelucchi S, Ravasi G, Lombardi C, Bilo G, Revera M, Giuliano A, Faini A, Mainini V, Westerman M, Ganz T, Valsecchi MG, Mancia G, Parati G. Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood. 2011 Mar 10; 117(10):2953-9. PMID: 21149632.
      View in: PubMed
    111. Goodnough LT, Nemeth E, Ganz T. Detection, evaluation, and management of iron-restricted erythropoiesis. Blood. 2010 Dec 02; 116(23):4754-61. PMID: 20826717.
      View in: PubMed
    112. Maes K, Nemeth E, Roodman GD, Huston A, Esteve F, Freytes C, Callander N, Katodritou E, Tussing-Humphreys L, Rivera S, Vanderkerken K, Lichtenstein A, Ganz T. In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. Blood. 2010 Nov 04; 116(18):3635-44. PMID: 20679527.
      View in: PubMed
    113. Bachman E, Feng R, Travison T, Li M, Olbina G, Ostland V, Ulloor J, Zhang A, Basaria S, Ganz T, Westerman M, Bhasin S. Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. J Clin Endocrinol Metab. 2010 Oct; 95(10):4743-7. PMID: 20660052.
      View in: PubMed
    114. Chen Q, Hakimi M, Wu S, Jin Y, Cheng B, Wang H, Xie G, Ganz T, Linzmeier RM, Fang X. Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population. Anesthesiology. 2010 Jun; 112(6):1428-34. PMID: 20502117.
      View in: PubMed
    115. Ayoya MA, Spiekermann-Brouwer GM, Stoltzfus RJ, Nemeth E, Habicht JP, Ganz T, Rawat R, Traoré AK, Garza C. Alpha 1-acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium. Am J Clin Nutr. 2010 Jun; 91(6):1784-90. PMID: 20410090.
      View in: PubMed
    116. Zaritsky J, Young B, Gales B, Wang HJ, Rastogi A, Westerman M, Nemeth E, Ganz T, Salusky IB. Reduction of serum hepcidin by hemodialysis in pediatric and adult patients. Clin J Am Soc Nephrol. 2010 Jun; 5(6):1010-4. PMID: 20299375.
      View in: PubMed
    117. Bdeir K, Higazi AA, Kulikovskaya I, Christofidou-Solomidou M, Vinogradov SA, Allen TC, Idell S, Linzmeier R, Ganz T, Cines DB. Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier. Am J Respir Crit Care Med. 2010 May 01; 181(9):935-46. PMID: 20093642.
      View in: PubMed
    118. Ferrucci L, Semba RD, Guralnik JM, Ershler WB, Bandinelli S, Patel KV, Sun K, Woodman RC, Andrews NC, Cotter RJ, Ganz T, Nemeth E, Longo DL. Proinflammatory state, hepcidin, and anemia in older persons. Blood. 2010 May 06; 115(18):3810-6. PMID: 20081092.
      View in: PubMed
    119. Kroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, Swinkels DW. Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica. 2009 Dec; 94(12):1748-52. PMID: 19996119.
      View in: PubMed
    120. Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol. 2009; 122(2-3):78-86. PMID: 19907144.
      View in: PubMed
    121. Rivera S, Ganz T. Animal models of anemia of inflammation. Semin Hematol. 2009 Oct; 46(4):351-7. PMID: 19786203.
      View in: PubMed
    122. Ganz T, Nemeth E. Iron sequestration and anemia of inflammation. Semin Hematol. 2009 Oct; 46(4):387-93. PMID: 19786207.
      View in: PubMed
    123. Girelli D, Pasino M, Goodnough JB, Nemeth E, Guido M, Castagna A, Busti F, Campostrini N, Martinelli N, Vantini I, Corrocher R, Ganz T, Fattovich G. Reduced serum hepcidin levels in patients with chronic hepatitis C. J Hepatol. 2009 Nov; 51(5):845-52. PMID: 19729219.
      View in: PubMed
    124. Katodritou E, Ganz T, Terpos E, Verrou E, Olbina G, Gastari V, Hadjiaggelidou C, Varthaliti M, Georgiadou S, Westerman M, Zervas K. Sequential evaluation of serum hepcidin in anemic myeloma patients: study of correlations with myeloma treatment, disease variables, and anemia response. Am J Hematol. 2009 Aug; 84(8):524-6. PMID: 19536845.
      View in: PubMed
    125. Sham RL, Phatak PD, Nemeth E, Ganz T. Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation. Blood. 2009 Jul 09; 114(2):493-4. PMID: 19589941.
      View in: PubMed
    126. Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 2009 Jul 02; 114(1):181-6. PMID: 19414861.
      View in: PubMed
    127. Zaritsky J, Young B, Wang HJ, Westerman M, Olbina G, Nemeth E, Ganz T, Rivera S, Nissenson AR, Salusky IB. Hepcidin--a potential novel biomarker for iron status in chronic kidney disease. Clin J Am Soc Nephrol. 2009 Jun; 4(6):1051-6. PMID: 19406957.
      View in: PubMed
    128. Fernandes A, Preza GC, Phung Y, De Domenico I, Kaplan J, Ganz T, Nemeth E. The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood. 2009 Jul 09; 114(2):437-43. PMID: 19383972.
      View in: PubMed
    129. Ruivard M, Lainé F, Ganz T, Olbina G, Westerman M, Nemeth E, Rambeau M, Mazur A, Gerbaud L, Tournilhac V, Abergel A, Philippe P, Deugnier Y, Coudray C. Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. J Hepatol. 2009 Jun; 50(6):1219-25. PMID: 19398238.
      View in: PubMed
    130. Troadec MB, Lainé F, Daniel V, Rochcongar P, Ropert M, Cabillic F, Perrin M, Morcet J, Loréal O, Olbina G, Westerman M, Nemeth E, Ganz T, Brissot P. Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism. Eur J Appl Physiol. 2009 Jun; 106(3):435-43. PMID: 19306018.
      View in: PubMed
    131. Ganz T. Iron in innate immunity: starve the invaders. Curr Opin Immunol. 2009 Feb; 21(1):63-7. PMID: 19231148.
      View in: PubMed
    132. Wilson CL, Schmidt AP, Pirilä E, Valore EV, Ferri N, Sorsa T, Ganz T, Parks WC. Differential Processing of {alpha}- and {beta}-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7). J Biol Chem. 2009 Mar 27; 284(13):8301-11. PMID: 19181662.
      View in: PubMed
    133. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin. Blood. 2008 Nov 15; 112(10):4292-7. PMID: 18689548.
      View in: PubMed
    134. De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J. The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab. 2008 Aug; 8(2):146-56. PMID: 18680715.
      View in: PubMed
    135. Sharma S, Nemeth E, Chen YH, Goodnough J, Huston A, Roodman GD, Ganz T, Lichtenstein A. Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res. 2008 Jun 01; 14(11):3262-7. PMID: 18519751.
      View in: PubMed
    136. Winder A, Lefkowitz R, Ghoti H, Leiba M, Ganz T, Nemeth E, Rachmilewitz EA. Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis. Br J Haematol. 2008 Aug; 142(4):669-71. PMID: 18498424.
      View in: PubMed
    137. Barisani D, Pelucchi S, Mariani R, Galimberti S, Trombini P, Fumagalli D, Meneveri R, Nemeth E, Ganz T, Piperno A. Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload. J Hepatol. 2008 Jul; 49(1):123-33. PMID: 18462824.
      View in: PubMed
    138. Ganz T. Iron homeostasis: fitting the puzzle pieces together. Cell Metab. 2008 Apr; 7(4):288-90. PMID: 18396134.
      View in: PubMed
    139. Bozzini C, Campostrini N, Trombini P, Nemeth E, Castagna A, Tenuti I, Corrocher R, Camaschella C, Ganz T, Olivieri O, Piperno A, Girelli D. Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. Blood Cells Mol Dis. 2008 May-Jun; 40(3):347-52. PMID: 18164223.
      View in: PubMed
    140. Aberg KM, Radek KA, Choi EH, Kim DK, Demerjian M, Hupe M, Kerbleski J, Gallo RL, Ganz T, Mauro T, Feingold KR, Elias PM. Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest. 2007 Nov; 117(11):3339-49. PMID: 17975669.
      View in: PubMed
    141. Aberg KM, Man MQ, Gallo RL, Ganz T, Crumrine D, Brown BE, Choi EH, Kim DK, Schröder JM, Feingold KR, Elias PM. Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol. 2008 Apr; 128(4):917-25. PMID: 17943185.
      View in: PubMed
    142. Trombini P, Coliva T, Nemeth E, Mariani R, Ganz T, Biondi A, Piperno A. Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia. Haematologica. 2007 Oct; 92(10):1407-10. PMID: 17768112.
      View in: PubMed
    143. Valore EV, Ganz T. Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol Dis. 2008 Jan-Feb; 40(1):132-8. PMID: 17905609.
      View in: PubMed
    144. Bullard RS, Gibson W, Bose SK, Belgrave JK, Eaddy AC, Wright CJ, Hazen-Martin DJ, Lage JM, Keane TE, Ganz TA, Donald CD. Functional analysis of the host defense peptide Human Beta Defensin-1: new insight into its potential role in cancer. Mol Immunol. 2008 Feb; 45(3):839-48. PMID: 17868871.
      View in: PubMed
    145. Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T. Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis. 2008 Jan-Feb; 40(1):122-31. PMID: 17869549.
      View in: PubMed
    146. Piperno A, Girelli D, Nemeth E, Trombini P, Bozzini C, Poggiali E, Phung Y, Ganz T, Camaschella C. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood. 2007 Dec 01; 110(12):4096-100. PMID: 17724144.
      View in: PubMed
    147. Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, Moroney JW, Reed CH, Luban NL, Wang RH, Eling TE, Childs R, Ganz T, Leitman SF, Fucharoen S, Miller JL. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007 Sep; 13(9):1096-101. PMID: 17721544.
      View in: PubMed
    148. Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007 Sep 15; 110(6):2182-9. PMID: 17540841.
      View in: PubMed
    149. De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell. 2007 Jul; 18(7):2569-78. PMID: 17475779.
      View in: PubMed
    150. Origa R, Galanello R, Ganz T, Giagu N, Maccioni L, Faa G, Nemeth E. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica. 2007 May; 92(5):583-8. PMID: 17488680.
      View in: PubMed
    151. Ganz T. Molecular control of iron transport. J Am Soc Nephrol. 2007 Feb; 18(2):394-400. PMID: 17229910.
      View in: PubMed
    152. Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein DA, Cunningham MJ. Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer. 2007 Jan; 48(1):57-63. PMID: 16220548.
      View in: PubMed
    153. Valore EV, Wiley DJ, Ganz T. Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect Immun. 2006 Oct; 74(10):5693-702. PMID: 16988245.
      View in: PubMed
    154. De Domenico I, McVey Ward D, Nemeth E, Ganz T, Corradini E, Ferrara F, Musci G, Pietrangelo A, Kaplan J. Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica. 2006 Aug; 91(8):1092-5. PMID: 16885049.
      View in: PubMed
    155. Tan BH, Meinken C, Bastian M, Bruns H, Legaspi A, Ochoa MT, Krutzik SR, Bloom BR, Ganz T, Modlin RL, Stenger S. Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. J Immunol. 2006 Aug 01; 177(3):1864-71. PMID: 16849498.
      View in: PubMed
    156. Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood. 2006 Dec 01; 108(12):3730-5. PMID: 16882706.
      View in: PubMed
    157. Pospisilova D, Mims MP, Nemeth E, Ganz T, Prchal JT. DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis. Blood. 2006 Jul 01; 108(1):404-5. PMID: 16790587.
      View in: PubMed
    158. Sørensen OE, Thapa DR, Roupé KM, Valore EV, Sjöbring U, Roberts AA, Schmidtchen A, Ganz T. Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. J Clin Invest. 2006 Jul; 116(7):1878-85. PMID: 16778986.
      View in: PubMed
    159. Nemeth E, Ganz T. Hepcidin and iron-loading anemias. Haematologica. 2006 Jun; 91(6):727-32. PMID: 16769573.
      View in: PubMed
    160. Ganz T, Nemeth E. Regulation of iron acquisition and iron distribution in mammals. Biochim Biophys Acta. 2006 Jul; 1763(7):690-9. PMID: 16790283.
      View in: PubMed
    161. Ganz T. Molecular pathogenesis of anemia of chronic disease. Pediatr Blood Cancer. 2006 May 01; 46(5):554-7. PMID: 16261603.
      View in: PubMed
    162. Linzmeier RM, Ganz T. Copy number polymorphisms are not a common feature of innate immune genes. Genomics. 2006 Jul; 88(1):122-6. PMID: 16617005.
      View in: PubMed
    163. Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol. 2006 Feb; 290(2):G199-203. PMID: 16407589.
      View in: PubMed
    164. Ganz T. Hepcidin and its role in regulating systemic iron metabolism. Hematology Am Soc Hematol Educ Program. 2006; 29-35, 507. PMID: 17124036.
      View in: PubMed
    165. Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr. 2006; 26:323-42. PMID: 16848710.
      View in: PubMed
    166. Ganz T. Hepcidin--a peptide hormone at the interface of innate immunity and iron metabolism. Curr Top Microbiol Immunol. 2006; 306:183-98. PMID: 16909922.
      View in: PubMed
    167. Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, Stange EF, Bevins CL. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18129-34. PMID: 16330776.
      View in: PubMed
    168. Porto G, Roetto A, Daraio F, Pinto JP, Almeida S, Bacelar C, Nemeth E, Ganz T, Camaschella C. A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron. Blood. 2005 Oct 15; 106(8):2922-3. PMID: 16204153.
      View in: PubMed
    169. Cole AM, Thapa DR, Gabayan V, Liao HI, Liu L, Ganz T. Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M. J Leukoc Biol. 2005 Nov; 78(5):1081-5. PMID: 16204648.
      View in: PubMed
    170. Linzmeier RM, Ganz T. Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. Genomics. 2005 Oct; 86(4):423-30. PMID: 16039093.
      View in: PubMed
    171. Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood. 2006 Jan 01; 107(1):328-33. PMID: 16141345.
      View in: PubMed
    172. Porter E, Yang H, Yavagal S, Preza GC, Murillo O, Lima H, Greene S, Mahoozi L, Klein-Patel M, Diamond G, Gulati S, Ganz T, Rice PA, Quayle AJ. Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infect Immun. 2005 Aug; 73(8):4823-33. PMID: 16040996.
      View in: PubMed
    173. Zoller H, McFarlane I, Theurl I, Stadlmann S, Nemeth E, Oxley D, Ganz T, Halsall DJ, Cox TM, Vogel W. Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease. Hepatology. 2005 Aug; 42(2):466-72. PMID: 15986403.
      View in: PubMed
    174. Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood. 2005 Oct 15; 106(8):2884-9. PMID: 15998830.
      View in: PubMed
    175. De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J. The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):8955-60. PMID: 15956209.
      View in: PubMed
    176. Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood. 2005 Sep 15; 106(6):2196-9. PMID: 15933050.
      View in: PubMed
    177. Ganz T. Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol. 2005 Jun; 18(2):171-82. PMID: 15737883.
      View in: PubMed
    178. Miller LS, Sørensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, Chung W, Starner TD, Kim J, Sieling PA, Ganz T, Modlin RL. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol. 2005 May 15; 174(10):6137-43. PMID: 15879109.
      View in: PubMed
    179. Ganz T. Defensins and other antimicrobial peptides: a historical perspective and an update. Comb Chem High Throughput Screen. 2005 May; 8(3):209-17. PMID: 15892623.
      View in: PubMed
    180. Liuzzi JP, Lichten LA, Rivera S, Blanchard RK, Aydemir TB, Knutson MD, Ganz T, Cousins RJ. Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6843-8. PMID: 15863613.
      View in: PubMed
    181. Sørensen OE, Thapa DR, Rosenthal A, Liu L, Roberts AA, Ganz T. Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol. 2005 Apr 15; 174(8):4870-9. PMID: 15814714.
      View in: PubMed
    182. Détivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, Ropert M, Jacquelinet S, Courselaud B, Ganz T, Brissot P, Loréal O. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood. 2005 Jul 15; 106(2):746-8. PMID: 15797999.
      View in: PubMed
    183. Ganz T. Cellular iron: ferroportin is the only way out. Cell Metab. 2005 Mar; 1(3):155-7. PMID: 16054057.
      View in: PubMed
    184. Papanikolaou G, Tzilianos M, Christakis JI, Bogdanos D, Tsimirika K, MacFarlane J, Goldberg YP, Sakellaropoulos N, Ganz T, Nemeth E. Hepcidin in iron overload disorders. Blood. 2005 May 15; 105(10):4103-5. PMID: 15671438.
      View in: PubMed
    185. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004 Dec 17; 306(5704):2090-3. PMID: 15514116.
      View in: PubMed
    186. Ross DJ, Cole AM, Yoshioka D, Park AK, Belperio JA, Laks H, Strieter RM, Lynch JP, Kubak B, Ardehali A, Ganz T. Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation. Transplantation. 2004 Oct 27; 78(8):1222-4. PMID: 15502724.
      View in: PubMed
    187. Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. Hepcidin is decreased in TFR2 hemochromatosis. Blood. 2005 Feb 15; 105(4):1803-6. PMID: 15486069.
      View in: PubMed
    188. Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood. 2005 Feb 15; 105(4):1797-802. PMID: 15479721.
      View in: PubMed
    189. Kalfa VC, Spector SL, Ganz T, Cole AM. Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis. Ann Allergy Asthma Immunol. 2004 Sep; 93(3):288-92. PMID: 15478391.
      View in: PubMed
    190. Ganz T. Hepcidin in iron metabolism. Curr Opin Hematol. 2004 Jul; 11(4):251-4. PMID: 15314524.
      View in: PubMed
    191. Matthes T, Aguilar-Martinez P, Pizzi-Bosman L, Darbellay R, Rubbia-Brandt L, Giostra E, Michel M, Ganz T, Beris P. Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP gene. Blood. 2004 Oct 01; 104(7):2181-3. PMID: 15198949.
      View in: PubMed
    192. Ganz T. Defensins: antimicrobial peptides of vertebrates. C R Biol. 2004 Jun; 327(6):539-49. PMID: 15330253.
      View in: PubMed
    193. Lee HY, Andalibi A, Webster P, Moon SK, Teufert K, Kang SH, Li JD, Nagura M, Ganz T, Lim DJ. Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae. BMC Infect Dis. 2004 May 05; 4:12. PMID: 15125783.
      View in: PubMed
    194. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004 May; 113(9):1271-6. PMID: 15124018.
      View in: PubMed
    195. Hertz CJ, Wu Q, Porter EM, Zhang YJ, Weismüller KH, Godowski PJ, Ganz T, Randell SH, Modlin RL. Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol. 2003 Dec 15; 171(12):6820-6. PMID: 14662888.
      View in: PubMed
    196. Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dubé MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, Radomski CC, Pape TD, Davidas O, Christakis J, Brissot P, Lockitch G, Ganz T, Hayden MR, Goldberg YP. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004 Jan; 36(1):77-82. PMID: 14647275.
      View in: PubMed
    197. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol. 2003 Sep; 3(9):710-20. PMID: 12949495.
      View in: PubMed
    198. Ganz T. Antimicrobial polypeptides. J Leukoc Biol. 2004 Jan; 75(1):34-8. PMID: 12960278.
      View in: PubMed
    199. Sørensen OE, Cowland JB, Theilgaard-Mönch K, Liu L, Ganz T, Borregaard N. Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J Immunol. 2003 Jun 01; 170(11):5583-9. PMID: 12759437.
      View in: PubMed
    200. Ganz T. Microbiology: Gut defence. Nature. 2003 Apr 03; 422(6931):478-9. PMID: 12673233.
      View in: PubMed
    201. Donald CD, Sun CQ, Lim SD, Macoska J, Cohen C, Amin MB, Young AN, Ganz TA, Marshall FF, Petros JA. Cancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas. Lab Invest. 2003 Apr; 83(4):501-5. PMID: 12695553.
      View in: PubMed
    202. Ganz T. The role of antimicrobial peptides in innate immunity. Integr Comp Biol. 2003 Apr; 43(2):300-4. PMID: 21680437.
      View in: PubMed
    203. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 2003 Aug 01; 102(3):783-8. PMID: 12663437.
      View in: PubMed
    204. Ganz T. Angiogenin: an antimicrobial ribonuclease. Nat Immunol. 2003 Mar; 4(3):213-4. PMID: 12605229.
      View in: PubMed
    205. Cole AM, Liao HI, Ganz T, Yang OO. Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1. FEBS Lett. 2003 Jan 30; 535(1-3):195-9. PMID: 12560103.
      View in: PubMed
    206. Com E, Bourgeon F, Evrard B, Ganz T, Colleu D, Jégou B, Pineau C. Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans. Biol Reprod. 2003 Jan; 68(1):95-104. PMID: 12493700.
      View in: PubMed
    207. Liu L, Roberts AA, Ganz T. By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J Immunol. 2003 Jan 01; 170(1):575-80. PMID: 12496445.
      View in: PubMed
    208. Cole AM, Liao HI, Stuchlik O, Tilan J, Pohl J, Ganz T. Cationic polypeptides are required for antibacterial activity of human airway fluid. J Immunol. 2002 Dec 15; 169(12):6985-91. PMID: 12471133.
      View in: PubMed
    209. Huang GT, Zhang HB, Kim D, Liu L, Ganz T. A model for antimicrobial gene therapy: demonstration of human beta-defensin 2 antimicrobial activities in vivo. Hum Gene Ther. 2002 Nov 20; 13(17):2017-25. PMID: 12489997.
      View in: PubMed
    210. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003 Apr 01; 101(7):2461-3. PMID: 12433676.
      View in: PubMed
    211. Ganz T. Immunology. Versatile defensins. Science. 2002 Nov 01; 298(5595):977-9. PMID: 12411693.
      View in: PubMed
    212. Ganz T. The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic disease. Isr Med Assoc J. 2002 Nov; 4(11):1043-5. PMID: 12489503.
      View in: PubMed
    213. Ganz T, Gabayan V, Liao HI, Liu L, Oren A, Graf T, Cole AM. Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan. Blood. 2003 Mar 15; 101(6):2388-92. PMID: 12411294.
      View in: PubMed
    214. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, Gallo RL, Leung DY. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med. 2002 Oct 10; 347(15):1151-60. PMID: 12374875.
      View in: PubMed
    215. Valore EV, Park CH, Igreti SL, Ganz T. Antimicrobial components of vaginal fluid. Am J Obstet Gynecol. 2002 Sep; 187(3):561-8. PMID: 12237628.
      View in: PubMed
    216. Hunter HN, Fulton DB, Ganz T, Vogel HJ. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem. 2002 Oct 04; 277(40):37597-603. PMID: 12138110.
      View in: PubMed
    217. Hein M, Valore EV, Helmig RB, Uldbjerg N, Ganz T. Antimicrobial factors in the cervical mucus plug. Am J Obstet Gynecol. 2002 Jul; 187(1):137-44. PMID: 12114901.
      View in: PubMed
    218. Moon SK, Lee HY, Li JD, Nagura M, Kang SH, Chun YM, Linthicum FH, Ganz T, Andalibi A, Lim DJ. Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells. Biochim Biophys Acta. 2002 Jun 12; 1590(1-3):41-51. PMID: 12063167.
      View in: PubMed
    219. Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol. 2002 Jun; 3(6):583-90. PMID: 12021776.
      View in: PubMed
    220. Levy O, Sisson RB, Fryer HE, Goldmann D, Valore E, Ganz T, White ML, Carroll SF, Lehmann L, Guinan EC. Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils. Transplantation. 2002 May 15; 73(9):1522-6. PMID: 12023636.
      View in: PubMed
    221. Ganz T. Epithelia: not just physical barriers. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3357-8. PMID: 11904396.
      View in: PubMed
    222. Henneman E, Dracup K, Ganz T, Molayeme O, Cooper CB. Using a collaborative weaning plan to decrease duration of mechanical ventilation and length of stay in the intensive care unit for patients receiving long-term ventilation. Am J Crit Care. 2002 Mar; 11(2):132-40. PMID: 11888125.
      View in: PubMed
    223. Ganz T. Antimicrobial polypeptides in host defense of the respiratory tract. J Clin Invest. 2002 Mar; 109(6):693-7. PMID: 11901174.
      View in: PubMed
    224. Liu AY, Destoumieux D, Wong AV, Park CH, Valore EV, Liu L, Ganz T. Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol. 2002 Feb; 118(2):275-81. PMID: 11841544.
      View in: PubMed
    225. Lehrer RI, Ganz T. Defensins of vertebrate animals. Curr Opin Immunol. 2002 Feb; 14(1):96-102. PMID: 11790538.
      View in: PubMed
    226. Sanchez JF, Wojcik F, Yang YS, Strub MP, Strub JM, Van Dorsselaer A, Martin M, Lehrer R, Ganz T, Chavanieu A, Calas B, Aumelas A. Overexpression and structural study of the cathelicidin motif of the protegrin-3 precursor. Biochemistry. 2002 Jan 08; 41(1):21-30. PMID: 11771999.
      View in: PubMed
    227. Cole AM, Ganz T. Antimicrobial peptides and proteins in the CF airway. Methods Mol Med. 2002; 70:447-64. PMID: 11917542.
      View in: PubMed
    228. Lehrer RI, Ganz T. Cathelicidins: a family of endogenous antimicrobial peptides. Curr Opin Hematol. 2002 Jan; 9(1):18-22. PMID: 11753073.
      View in: PubMed
    229. Ganz T. Fatal attraction evaded. How pathogenic bacteria resist cationic polypeptides. J Exp Med. 2001 May 07; 193(9):F31-4. PMID: 11342596.
      View in: PubMed
    230. Ganz T. Defensins in the urinary tract and other tissues. J Infect Dis. 2001 Mar 01; 183 Suppl 1:S41-2. PMID: 11171012.
      View in: PubMed
    231. Ganz T. Defensins and host defense. Science. 1999 Oct 15; 286(5439):420-1. PMID: 10577203.
      View in: PubMed