Tomas Ganz

Title(s)Professor, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0002-2830-5469 Additional info
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    Other Positions
    Title(s)Professor, Pathology and Laboratory Medicine


    Collapse Biography 
    Collapse Education and Training
    UCLA, Los AngelesBS06/70Physics
    California Institute of Technology, Pasadena, CAPhD06/76Applied Physics
    UCLA School of Medicine, Los AngelesMD05/78Medicine
    Collapse Awards and Honors
    International Bioiron Society2005Marcel Simon Prize
    American Association of Physicians2006Elected Member
    UCLA Medical Alumni Association2007Medical Science Award
    American Society of Hematology2014E. Donnall Thomas Prize
    Charles University of Prague2021Gold Medal for Achievements in Immunology and Pathophysiology

    Collapse Overview 
    Collapse Overview
    Tomas Ganz is a Distinguished Professor of Medicine and Pathology at UCLA. He received his PhD from the California Institute of Technology in Applied Physics and MD and advanced medical training from UCLA. He discovered and characterized hepcidin and erythroferrone, the principal hormones of iron homeostasis, authoring more than 300 publications and more than 30 book chapters, with current H-index of 162 (Google Scholar). Dr. Ganz has served as an Associate Editor of Blood, President of the International Bioiron Society and a member of the hematology-focused study sections of the National Institutes of Health. He has helped start three biotechnology enterprises, focused on the diagnostic and therapeutic applications of hepcidin and erythroferrone, and has advised leading pharmaceutical and biotechnology companies. He received the Marcel Simon Award of the International Bioiron Society in 2005, for the discovery of hepcidin and the American Society of Hematology E. Donnall Thomas Award in 2014 for “groundbreaking research in iron homeostasis, including the discovery of the iron-regulatory hormone hepcidin and investigation of its roles in iron metabolism”. He has trained more than thirty graduate students, postdoctoral fellows and junior faculty in his research laboratory. His current research interests include systemic iron metabolism and its regulation, the role of iron in innate immunity and infection, the interaction between erythropoiesis and iron homeostasis, and the pathogenesis of beta-thalassemia and other iron-loading anemias.

    Collapse Research 
    Collapse Research Activities and Funding
    KUH-ART: Advanced Research Training in Kidney disease, Urology and Hematology
    NIH U2CDK129496Sep 15, 2021 - May 31, 2026
    Role: Co-Principal Investigator
    MECHANISM OF ACTION OF ERYTHROFERRONE AND PATHOLOGICAL IMPLICATIONS
    NIH R01DK126680Sep 20, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Bioiron 2013: From basic science to medicine
    NIH R13DK098971Apr 1, 2013 - Mar 31, 2014
    Role: Principal Investigator
    Bioiron 2011: From basic science to medicine
    NIH R13DK092102May 1, 2011 - Apr 30, 2012
    Role: Principal Investigator
    Activin signaling in normal and disordered erythropoiesis
    NIH R01DK090554Sep 30, 2010 - Jan 31, 2022
    Role: Co-Principal Investigator
    THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    NIH R01HL091531Jun 15, 2007 - May 31, 2011
    Role: Principal Investigator
    The role of hemojuvelin in the regulation of iron metabolism
    NIH R21DK073226Feb 15, 2006 - Jan 31, 2008
    Role: Principal Investigator
    UCLA Pulmonary and Critical Care Medicine Training Program
    NIH T32HL072752Jul 1, 2003 - Apr 30, 2025
    Role: Co-Principal Investigator
    The role of erythroferrone in iron homeostasis and in iron-loading anemias
    NIH R01DK065029Jul 1, 2003 - Dec 31, 2018
    Role: Principal Investigator
    NASAL CARRIAGE OF STAPHYLOCOCCUS AUREUS
    NIH R21AI048167Sep 30, 2000 - Sep 29, 2003
    Role: Principal Investigator
    INNATE HOST DEFENSE IN THE HUMAN VAGINA
    NIH R01AI046514Sep 15, 2000 - Aug 31, 2005
    Role: Principal Investigator
    CONFERENCE ANTIMICROBIAL PEPTIDES OF HIGHER EUKARYOTES
    NIH R13AI040440Mar 1, 1997 - Feb 28, 1998
    Role: Principal Investigator
    BETA-DEFENSINS IN THE FEMALE GENITAL TRACT AND KIDNEYS
    NIH R01AI040248Aug 1, 1996 - Jul 31, 2001
    Role: Principal Investigator
    IMMUNOPOTENTIATION BY TRANSGENIC ANTIMICROBIAL PEPTIDES
    NIH R01AI038567Sep 30, 1995 - Jul 31, 1998
    Role: Principal Investigator
    Human Defensins in Phagocytes and Epithelia
    NIH R01HL046809Jan 1, 1993 - Jun 30, 2005
    Role: Principal Investigator
    CATIONIC PEPTIDES AND THE LUNG
    NIH R01HL035640Dec 1, 1985 - Jun 30, 1995
    Role: Principal Investigator
    MICROBICIDAL MECHANISMS AGAINST PNEUMOCYSTIS CARINII
    NIH R01AI021931Sep 30, 1984 - Aug 31, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hepcidin and Erythroferrone Complement the Athlete Biological Passport in the Detection of Autologous Blood Transfusion. Med Sci Sports Exerc. 2022 Apr 25. Andersen AB, Bejder J, Bonne TC, Sørensen H, Sørensen H, Jung G, Ganz T, Nemeth E, Secher NH, Johansson PI, Nordsborg NB. PMID: 35482790.
      View in: PubMed   Mentions:
    2. Renoprotective effects of ferric citrate in a mouse model of chronic kidney disease. Sci Rep. 2022 Apr 23; 12(1):6695. Hanudel MR, Czaya B, Wong S, Jung G, Chua K, Qiao B, Gabayan V, Ganz T. PMID: 35461329; PMCID: PMC9035171.
      View in: PubMed   Mentions:
    3. Human defensin-inspired discovery of peptidomimetic antibiotics. Proc Natl Acad Sci U S A. 2022 03 08; 119(10):e2117283119. Luo G, Zhang J, Wang H, Sun Y, Cheng B, Xu Z, Zhang Y, Li H, Lu W, Nemeth E, Ganz T, Fang X. PMID: 35238683; PMCID: PMC8916014.
      View in: PubMed   Mentions:
    4. Hepcidin is elevated in primary and secondary myelofibrosis and remains elevated in patients treated with ruxolitinib. Br J Haematol. 2022 Feb 06. Zhou A, Kong T, Fowles JS, Jung CL, Allen MJ, Fisher DAC, Fulbright M, Nemeth E, Ganz T, Oh ST. PMID: 35128632.
      View in: PubMed   Mentions:
    5. Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice. Blood. 2022 01 20; 139(3):439-451. Coffey R, Jung G, Olivera JD, Karin G, Pereira RC, Nemeth E, Ganz T. PMID: 34614145; PMCID: PMC8777203.
      View in: PubMed   Mentions:    Fields:    
    6. Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression. Nano Lett. 2022 01 26; 22(2):751-760. Zhu J, Fu Q, Wang S, Ren L, Feng W, Wei S, Zhang Z, Xu Y, Ganz T, Liu S. PMID: 35030010.
      View in: PubMed   Mentions:
    7. Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin. Kidney Int. 2022 Apr; 101(4):711-719. Hanudel MR, Czaya B, Wong S, Rappaport M, Namjoshi S, Chua K, Jung G, Gabayan V, Qiao B, Nemeth E, Ganz T. PMID: 34838540; PMCID: PMC8940695.
      View in: PubMed   Mentions:
    8. Umbilical Cord Erythroferrone Is Inversely Associated with Hepcidin, but Does Not Capture the Most Variability in Iron Status of Neonates Born to Teens Carrying Singletons and Women Carrying Multiples. J Nutr. 2021 09 04; 151(9):2590-2600. Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O'Brien KO. PMID: 34236433; PMCID: PMC8417932.
      View in: PubMed   Mentions:    Fields:    
    9. Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosis. J Biol Chem. 2021 10; 297(4):101156. Fisher AL, Srole DN, Palaskas NJ, Meriwether D, Reddy ST, Ganz T, Nemeth E. PMID: 34480898; PMCID: PMC8463868.
      View in: PubMed   Mentions:    Fields:    
    10. New regulators of systemic iron homeostasis. Signal Transduct Target Ther. 2021 07 21; 6(1):280. Ganz T. PMID: 34290226; PMCID: PMC8295296.
      View in: PubMed   Mentions:
    11. Serum Erythroferrone During Pregnancy Is Related to Erythropoietin but Does Not Predict the Risk of Anemia. J Nutr. 2021 07 01; 151(7):1824-1833. Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O'Brien KO. PMID: 33982118; PMCID: PMC8245876.
      View in: PubMed   Mentions:    Fields:    
    12. Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy. Nat Commun. 2021 06 29; 12(1):4026. Fisher AL, Sangkhae V, Balušíková K, Palaskas NJ, Ganz T, Nemeth E. PMID: 34188052; PMCID: PMC8242011.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    13. Effects of altitude and recombinant human erythropoietin on iron metabolism: a randomized controlled trial. Am J Physiol Regul Integr Comp Physiol. 2021 08 01; 321(2):R152-R161. Breenfeldt Andersen A, Bonne TC, Bejder J, Jung G, Ganz T, Nemeth E, Olsen NV, Huertas JR, Nordsborg NB. PMID: 34160288; PMCID: PMC8887998.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis. Int J Mol Sci. 2021 Jun 17; 22(12). Nemeth E, Ganz T. PMID: 34204327; PMCID: PMC8235187.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model. J Clin Invest. 2021 05 17; 131(10). Matte A, Federti E, Kung C, Kosinski PA, Narayanaswamy R, Russo R, Federico G, Carlomagno F, Desbats MA, Salviati L, Leboeuf C, Valenti MT, Turrini F, Janin A, Yu S, Beneduce E, Ronseaux S, Iatcenko I, Dang L, Ganz T, Jung CL, Iolascon A, Brugnara C, De Franceschi L. PMID: 33822774; PMCID: PMC8121526.
      View in: PubMed   Mentions:
    16. Amelioration of chronic kidney disease-associated anemia by vadadustat in mice is not dependent on erythroferrone. Kidney Int. 2021 07; 100(1):79-89. Hanudel MR, Wong S, Jung G, Qiao B, Gabayan V, Zuk A, Ganz T. PMID: 33811979.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    17. Increase of plasma erythroferrone levels during high-altitude exposure: A sub-analysis of the TOP OF HOMe study. Am J Hematol. 2021 05 01; 96(5):E179-E181. Emrich IE, Scheuer A, Wagenpfeil S, Ganz T, Heine GH. PMID: 33606284.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    18. AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia. Gastroenterology. 2021 07; 161(1):362-365. Kaunitz JD, Ganz T. PMID: 33675744.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Parenteral iron therapy and phosphorus homeostasis: A review. Am J Hematol. 2021 05 01; 96(5):606-616. Kalantar-Zadeh K, Ganz T, Trumbo H, Seid MH, Goodnough LT, Levine MA. PMID: 33471363; PMCID: PMC8248123.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins. Biomedicines. 2021 Feb 08; 9(2). Goncalves Monteiro D, van Dijk JWA, Aliyanto R, Fung E, Nemeth E, Ganz T, Rosengren J, Clark RJ. PMID: 33567510; PMCID: PMC7915682.
      View in: PubMed   Mentions:
    21. Erythroferrone structure, function, and physiology: Iron homeostasis and beyond. J Cell Physiol. 2021 07; 236(7):4888-4901. Srole DN, Ganz T. PMID: 33372284; PMCID: PMC8026552.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    22. Isolation and thermal stabilization of mouse ferroportin. FEBS Open Bio. 2021 01; 11(1):26-34. Deshpande CN, Azucenas CR, Qiao B, Nomura N, Xin V, Font J, Iwata S, Ganz T, Nemeth E, Mackenzie B, Jormakka M. PMID: 33190422; PMCID: PMC7780100.
      View in: PubMed   Mentions:    Fields:    
    23. Maternal hepcidin determines embryo iron homeostasis in mice. Blood. 2020 11 05; 136(19):2206-2216. Sangkhae V, Fisher AL, Chua KJ, Ruchala P, Ganz T, Nemeth E. PMID: 32584957; PMCID: PMC7645983.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    24. The role of hepcidin in fetal iron homeostasis. Blood. 2020 09 24; 136(13):1474-1475. Ganz T. PMID: 32970808.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Prognostic associations of plasma hepcidin in women with early breast cancer. Breast Cancer Res Treat. 2020 Dec; 184(3):927-935. Jerzak KJ, Lohmann AE, Ennis M, Nemeth E, Ganz T, Goodwin PJ. PMID: 32960376; PMCID: PMC7883934.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial. Blood Adv. 2020 09 22; 4(18):4282-4291. Oh ST, Talpaz M, Gerds AT, Gupta V, Verstovsek S, Mesa R, Miller CB, Rivera CE, Fleischman AG, Goel S, Heaney ML, O'Connell C, Arcasoy MO, Zhang Y, Kawashima J, Ganz T, Kowalski M, Brachmann CB. PMID: 32915978; PMCID: PMC7509854.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    27. Clinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors. J Appl Lab Med. 2020 09 01; 5(5):943-953. Gutschow P, Han H, Olbina G, Westerman K, Nemeth E, Ganz T, Copeland K, Westerman M, Ostland V. PMID: 32674118; PMCID: PMC7497288.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Expression of Iron-Regulatory Hormone Hepcidin and Iron Transporters Ferroportin and ZIP8 in Patients With and Without Chronic Rhinosinusitis. Otolaryngol Head Neck Surg. 2020 Dec; 163(6):1270-1273. Hsu D, Kim A, Ganz T, Suh JD, Wang M, Wu TJ, Lee JT. PMID: 32746765.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. Erythropoiesis stimulating agents are associated with serum fibroblast growth factor 23 metabolism in patients on hemodialysis. Clin Kidney J. 2021 Mar; 14(3):943-949. Honda H, Tanaka K, Michihata T, Shibagaki K, Yuza T, Hirao K, Tomosugi N, Ganz T, Higashimoto Y. PMID: 33777378; PMCID: PMC7986323.
      View in: PubMed   Mentions:
    30. Iron overload causes a mild and transient increase in acute lung injury. Physiol Rep. 2020 06; 8(12):e14470. Zhang V, Ganz T, Nemeth E, Kim A. PMID: 32596989; PMCID: PMC7322498.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    31. The Authors Reply. Kidney Int Rep. 2020 Jul; 5(7):1119-1120. Sharma S, Hanudel MR, Ix JH, Salusky IB, Ganz T, Nguyen KL. PMID: 32647775; PMCID: PMC7335947.
      View in: PubMed   Mentions:
    32. Author Correction: Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2020 Apr; 52(4):463. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. PMID: 32107478.
      View in: PubMed   Mentions: 1     Fields:    
    33. Iron Administration, Infection, and Anemia Management in CKD: Untangling the Effects of Intravenous Iron Therapy on Immunity and Infection Risk. Kidney Med. 2020 May-Jun; 2(3):341-353. Ganz T, Aronoff GR, Gaillard CAJM, Goodnough LT, Macdougall IC, Mayer G, Porto G, Winkelmayer WC, Wish JB. PMID: 32734254; PMCID: PMC7380433.
      View in: PubMed   Mentions: 3  
    34. Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy. JCI Insight. 2020 02 27; 5(4). Fisher AL, Sangkhae V, Presicce P, Chougnet CA, Jobe AH, Kallapur SG, Tabbah S, Buhimschi CS, Buhimschi IA, Ganz T, Nemeth E. PMID: 31990688; PMCID: PMC7101151.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    35. Drugging erythroferrone to treat anemias. Blood. 2020 02 20; 135(8):516-518. Ganz T. PMID: 32078688.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    36. Effects of maternal iron status on placental and fetal iron homeostasis. J Clin Invest. 2020 02 03; 130(2):625-640. Sangkhae V, Fisher AL, Wong S, Koenig MD, Tussing-Humphreys L, Chu A, Lelic M, Ganz T, Nemeth E. PMID: 31661462; PMCID: PMC6994143.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    37. Effects of erythropoietin on fibroblast growth factor 23 in mice and humans. Nephrol Dial Transplant. 2019 12 01; 34(12):2057-2065. Hanudel MR, Eisenga MF, Rappaport M, Chua K, Qiao B, Jung G, Gabayan V, Gales B, Ramos G, de Jong MA, van Zanden JJ, de Borst MH, Bakker SJL, Nemeth E, Salusky IB, Gaillard CAJM, Ganz T. PMID: 30007314; PMCID: PMC6888066.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    38. Anemia of Inflammation. N Engl J Med. 2019 Sep 19; 381(12):1148-1157. Ganz T. PMID: 31532961.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    39. Elevated Fibroblast Growth Factor 23 Levels Are Associated With Greater Diastolic Dysfunction in ESRD. Kidney Int Rep. 2019 Dec; 4(12):1748-1751. Sharma S, Hanudel MR, Ix JH, Salusky IB, Ganz T, Nguyen KL. PMID: 31844812; PMCID: PMC6895593.
      View in: PubMed   Mentions: 2  
    40. A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome. Sci Transl Med. 2019 07 10; 11(500). Bondu S, Alary AS, Lefèvre C, Houy A, Jung G, Lefebvre T, Rombaut D, Boussaid I, Bousta A, Guillonneau F, Perrier P, Alsafadi S, Wassef M, Margueron R, Rousseau A, Droin N, Cagnard N, Kaltenbach S, Winter S, Kubasch AS, Bouscary D, Santini V, Toma A, Hunault M, Stamatoullas A, Gyan E, Cluzeau T, Platzbecker U, Adès L, Puy H, Stern MH, Karim Z, Mayeux P, Nemeth E, Park S, Ganz T, Kautz L, Kosmider O, Fontenay M. PMID: 31292266; PMCID: PMC8005358.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    41. Novel Oral Iron Therapies for Iron Deficiency Anemia in Chronic Kidney Disease. Adv Chronic Kidney Dis. 2019 07; 26(4):272-291. Pergola PE, Fishbane S, Ganz T. PMID: 31477258.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    42. Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis. Haematologica. 2020 04; 105(4):937-950. Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, Okreglicka K, Hültner L, Schneider M, Ladinig C, Kuklik-Roos C, Mysliwietz J, Janik D, Neff F, Rathkolb B, de Angelis MTH, Buske C, Silva ARD, Muedder K, Conrad M, Ganz T, Kopf M, Muckenthaler MU, Bornkamm GW. PMID: 31248967; PMCID: PMC7109755.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    43. The Discovery of the Iron-Regulatory Hormone Hepcidin. Clin Chem. 2019 10; 65(10):1330-1331. Ganz T. PMID: 31235538.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    44. Mechanism of Action and Clinical Attributes of Auryxia® (Ferric Citrate). Drugs. 2019 Jun; 79(9):957-968. Ganz T, Bino A, Salusky IB. PMID: 31134521; PMCID: PMC6562046.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    45. William Ganz and His Legacy. Ann Intern Med. 2019 05 21; 170(10):734-735. Ganz T, Ganz P. PMID: 31108522.
      View in: PubMed   Mentions:    Fields:    
    46. Iron Metabolism in Chronic Kidney Disease Patients. Contrib Nephrol. 2019; 198:103-111. Honda H, Hosaka N, Ganz T, Shibata T. PMID: 30991401.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    47. New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia. Haematologica. 2019 09; 104(9):1768-1781. Liu J, Liu W, Liu Y, Miao Y, Guo Y, Song H, Wang F, Zhou H, Ganz T, Yan B, Liu S. PMID: 30792208; PMCID: PMC6717595.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    48. The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation. Radiat Res. 2019 04; 191(4):323-334. Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. PMID: 30730284; PMCID: PMC6482953.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsPHPublic Health
    49. Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3161-3170. Chen Q, Yang Y, Hou J, Shu Q, Yin Y, Fu W, Han F, Hou T, Zeng C, Nemeth E, Linzmeier R, Ganz T, Fang X. PMID: 30718392; PMCID: PMC6386704.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    50. Iron homeostasis in pregnancy and spontaneous abortion. Am J Hematol. 2019 02; 94(2):184-188. Guo Y, Zhang N, Zhang D, Ren Q, Ganz T, Liu S, Nemeth E. PMID: 30394565; PMCID: PMC6687303.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    51. Erythrocytes and erythroblasts give up iron. Blood. 2018 11 08; 132(19):2004-2005. Ganz T. PMID: 30409893.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    52. Anemia of inflammation. Blood. 2019 01 03; 133(1):40-50. Weiss G, Ganz T, Goodnough LT. PMID: 30401705; PMCID: PMC6536698.
      View in: PubMed   Mentions: 118     Fields:    Translation:Humans
    53. Erythropoietin and iron-a conflicted alliance? Kidney Int. 2018 11; 94(5):851-853. Ganz T. PMID: 30348300.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    54. Mechanisms responsible for reduced erythropoiesis during androgen deprivation therapy in men with prostate cancer. Am J Physiol Endocrinol Metab. 2018 12 01; 315(6):E1185-E1193. Gagliano-Jucá T, Pencina KM, Ganz T, Travison TG, Kantoff PW, Nguyen PL, Taplin ME, Kibel AS, Li Z, Huang G, Edwards RR, Nemeth E, Basaria S. PMID: 30325657; PMCID: PMC6336960.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    55. Erythroferrone is not required for the glucoregulatory and hematologic effects of chronic erythropoietin treatment in mice. Physiol Rep. 2018 09; 6(19):e13890. Coffey R, Sardo U, Kautz L, Gabayan V, Nemeth E, Ganz T. PMID: 30315639; PMCID: PMC6185995.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    56. Calcium is an essential cofactor for metal efflux by the ferroportin transporter family. Nat Commun. 2018 08 06; 9(1):3075. Deshpande CN, Ruwe TA, Shawki A, Xin V, Vieth KR, Valore EV, Qiao B, Ganz T, Nemeth E, Mackenzie B, Jormakka M. PMID: 30082682; PMCID: PMC6079014.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    57. Dysregulated iron metabolism in polycythemia vera: etiology and consequences. Leukemia. 2018 10; 32(10):2105-2116. Ginzburg YZ, Feola M, Zimran E, Varkonyi J, Ganz T, Hoffman R. PMID: 30042411; PMCID: PMC6170398.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    58. Erythropoietic regulators of iron metabolism. Free Radic Biol Med. 2019 03; 133:69-74. Ganz T. PMID: 29981834; PMCID: PMC6320727.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    59. Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients. Infect Immun. 2018 07; 86(7). Stefanova D, Raychev A, Deville J, Humphries R, Campeau S, Ruchala P, Nemeth E, Ganz T, Bulut Y. PMID: 29735522; PMCID: PMC6013672.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    60. Evaluation of serum markers for improved detection of autologous blood transfusions. Haematologica. 2018 10; 103(10):e443-e445. Cox HD, Miller GD, Lai A, Cushman D, Ganz T, Eichner D. PMID: 29674501; PMCID: PMC6165801.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    61. Iron storage disease (hemochromatosis) and hepcidin response to iron load in two species of pteropodid fruit bats relative to the common vampire bat. J Comp Physiol B. 2018 07; 188(4):683-694. Stasiak IM, Smith DA, Ganz T, Crawshaw GJ, Hammermueller JD, Bienzle D, Lillie BN. PMID: 29594459.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    62. Erythroferrone: An Erythroid Regulator of Hepcidin and Iron Metabolism. Hemasphere. 2018 Mar-Apr; 2(2):e35. Coffey R, Ganz T. PMID: 31723763; PMCID: PMC6745900.
      View in: PubMed   Mentions: 16  
    63. Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype. Hepatol Int. 2018 Mar; 12(2):83-86. Adams P, Altes A, Brissot P, Butzeck B, Cabantchik I, Cançado R, Distante S, Evans P, Evans R, Ganz T, Girelli D, Hultcrantz R, McLaren G, Marris B, Milman N, Nemeth E, Nielsen P, Pineau B, Piperno A, Porto G, Prince D, Ryan J, Sanchez M, Santos P, Swinkels D, Teixeira E, Toska K, Vanclooster A, White D, Contributors and Hemochromatosis International Taskforce. PMID: 29589198; PMCID: PMC5904234.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    64. Fetal presentation of congenital dyserythropoietic anemia type 1 with novel compound heterozygous CDAN1 mutations. Blood Cells Mol Dis. 2018 07; 71:63-66. Meznarich JA, Draper L, Christensen RD, Yaish HM, Luem ND, Pysher TJ, Jung G, Nemeth E, Ganz T, Ward DM. PMID: 29599085; PMCID: PMC5947870.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    65. Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell? Am J Nephrol. 2018; 47(2):72-83. Wish JB, Aronoff GR, Bacon BR, Brugnara C, Eckardt KU, Ganz T, Macdougall IC, Núñez J, Perahia AJ, Wood JC. PMID: 29439253.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    66. Levels of the erythropoietin-responsive hormone erythroferrone in mice and humans with chronic kidney disease. Haematologica. 2018 04; 103(4):e141-e142. Hanudel MR, Rappaport M, Chua K, Gabayan V, Qiao B, Jung G, Salusky IB, Ganz T, Nemeth E. PMID: 29419424; PMCID: PMC5865435.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    67. Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet". Biol Trace Elem Res. 2018 09; 185(1):252-254. Rzymski P, Ganz T. PMID: 29322429; PMCID: PMC6097060.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    68. Correction to: Iron and infection. Int J Hematol. 2018 01; 107(1):122. Ganz T. PMID: 29197980.
      View in: PubMed   Mentions: 1     Fields:    
    69. Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin. Blood. 2018 02 22; 131(8):899-910. Aschemeyer S, Qiao B, Stefanova D, Valore EV, Sek AC, Ruwe TA, Vieth KR, Jung G, Casu C, Rivella S, Jormakka M, Mackenzie B, Ganz T, Nemeth E. PMID: 29237594; PMCID: PMC5824336.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    70. Iron-related markers are associated with infection after liver transplantation. Liver Transpl. 2017 12; 23(12):1541-1552. Chow JKL, Ganz T, Ruthazer R, Simpson MA, Pomfret EA, Gordon FD, Westerman ME, Snydman DR. PMID: 28703464; PMCID: PMC5696081.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    71. Iron and infection. Int J Hematol. 2018 Jan; 107(1):7-15. Ganz T. PMID: 29147843.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    72. In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively than Iron and Erythropoietin Treatment. Shock. 2017 10; 48(4):490-497. Khorramian E, Fung E, Chua K, Gabayan V, Ganz T, Nemeth E, Kim A. PMID: 28452907; PMCID: PMC5603371.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    73. Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis. Antioxid Redox Signal. 2018 Jan 01; 28(1):1-14. Matte A, De Falco L, Federti E, Cozzi A, Iolascon A, Levi S, Mohandas N, Zamo A, Bruno M, Lebouef C, Janin A, Siciliano A, Ganz T, Federico G, Carlomagno F, Mueller S, Silva I, Carbone C, Melisi D, Kim DW, Choi SY, De Franceschi L. PMID: 28793778.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    74. Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow. Haematologica. 2017 11; 102(11):e427-e430. Clinkenbeard EL, Hanudel MR, Stayrook KR, Appaiah HN, Farrow EG, Cass TA, Summers LJ, Ip CS, Hum JM, Thomas JC, Ivan M, Richine BM, Chan RJ, Clemens TL, Schipani E, Sabbagh Y, Xu L, Srour EF, Alvarez MB, Kacena MA, Salusky IB, Ganz T, Nemeth E, White KE. PMID: 28818868; PMCID: PMC5664401.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    75. Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 01; 313(5):G511-G523. McLachlan S, Page KE, Lee SM, Loguinov A, Valore E, Hui ST, Jung G, Zhou J, Lusis AJ, Fuqua B, Ganz T, Nemeth E, Vulpe CD. PMID: 28798083; PMCID: PMC5792216.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    76. CXCL13 levels are elevated in patients with Waldenström macroglobulinemia, and are predictive of major response to ibrutinib. Haematologica. 2017 11; 102(11):e452-e455. Vos JM, Tsakmaklis N, Patterson CJ, Meid K, Castillo JJ, Brodsky P, Ganz T, Pals ST, Kersten MJ, Xu L, Yang G, Treon SP, Hunter ZR. PMID: 28798070; PMCID: PMC5664407.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    77. NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges. Nat Rev Drug Discov. 2017 10; 16(10):663-664. Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, Vince DG, Watts L, NIH Centers for Accelerated Innovations. PMID: 28775338; PMCID: PMC5963257.
      View in: PubMed   Mentions: 1     Fields:    
    78. Immunoassay for human serum erythroferrone. Blood. 2017 09 07; 130(10):1243-1246. Ganz T, Jung G, Naeim A, Ginzburg Y, Pakbaz Z, Walter PB, Kautz L, Nemeth E. PMID: 28739636; PMCID: PMC5606005.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    79. Iron homeostasis: An anthropocentric perspective. J Biol Chem. 2017 08 04; 292(31):12727-12734. Coffey R, Ganz T. PMID: 28615456; PMCID: PMC5546013.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    80. Does Pathological Iron Overload Impair the Function of Human Lungs? EBioMedicine. 2017 06; 20:13-14. Ganz T. PMID: 28545989; PMCID: PMC5478249.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    81. Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood. 2017 07 20; 130(3):245-257. Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E. PMID: 28465342; PMCID: PMC5520472.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    82. Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia. JCI Insight. 2017 03 23; 2(6):e92002. Michels KR, Zhang Z, Bettina AM, Cagnina RE, Stefanova D, Burdick MD, Vaulont S, Nemeth E, Ganz T, Mehrad B. PMID: 28352667; PMCID: PMC5358492.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    83. Mice lacking liver-specific β-catenin develop steatohepatitis and fibrosis after iron overload. J Hepatol. 2017 08; 67(2):360-369. Preziosi ME, Singh S, Valore EV, Jung G, Popovic B, Poddar M, Nagarajan S, Ganz T, Monga SP. PMID: 28341391; PMCID: PMC5515705.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    84. Erythroferrone and matriptase-2 independently regulate hepcidin expression. Am J Hematol. 2017 05; 92(5):E61-E63. Aschemeyer S, Gabayan V, Ganz T, Nemeth E, Kautz L. PMID: 28187515; PMCID: PMC5389904.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    85. Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model. Haematologica. 2017 03; 102(3):e85-e88. Hanudel MR, Rappaport M, Gabayan V, Jung G, Salusky IB, Nemeth E, Ganz T, Zaritsky J. PMID: 27884972; PMCID: PMC5394962.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    86. Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild-type and hepcidin knockout mice. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1369-F1377. Hanudel MR, Chua K, Rappaport M, Gabayan V, Valore E, Goltzman D, Ganz T, Nemeth E, Salusky IB. PMID: 27733366; PMCID: PMC5210202.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    87. Macrophages and Iron Metabolism. Microbiol Spectr. 2016 10; 4(5). Ganz T. PMID: 27763254.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    88. Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia. Haematologica. 2017 01; 102(1):60-68. Latour C, Wlodarczyk MF, Jung G, Gineste A, Blanchard N, Ganz T, Roth MP, Coppin H, Kautz L. PMID: 27658439; PMCID: PMC5210233.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    89. Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera. Blood. 2016 07 14; 128(2):265-76. Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S. PMID: 27154187; PMCID: PMC4946204.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    90. Iron Balance and the Role of Hepcidin in Chronic Kidney Disease. Semin Nephrol. 2016 03; 36(2):87-93. Ganz T, Nemeth E. PMID: 27236128; PMCID: PMC4884601.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    91. Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochim Biophys Acta. 2016 Apr; 1863(4):727-48. Kalinowski DS, Stefani C, Toyokuni S, Ganz T, Anderson GJ, Subramaniam NV, Trinder D, Olynyk JK, Chua A, Jansson PJ, Sahni S, Lane DJ, Merlot AM, Kovacevic Z, Huang ML, Lee CS, Richardson DR. PMID: 26844773.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    92. Hepcidin. Rinsho Ketsueki. 2016; 57(10):1913-1917. Ganz T. PMID: 27725588.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    93. Ironing out Ferroportin. Cell Metab. 2015 Nov 03; 22(5):777-87. Drakesmith H, Nemeth E, Ganz T. PMID: 26437604; PMCID: PMC4635047.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    94. Isocitrate treatment of acute anemia of inflammation in a mouse model. Blood Cells Mol Dis. 2016 Jan; 56(1):31-6. Kim A, Fung E, Parikh SG, Gabayan V, Nemeth E, Ganz T. PMID: 26603720; PMCID: PMC4660302.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    95. Hepcidin and Host Defense against Infectious Diseases. PLoS Pathog. 2015 Aug; 11(8):e1004998. Michels K, Nemeth E, Ganz T, Mehrad B. PMID: 26291319; PMCID: PMC4546197.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    96. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia. Blood. 2015 Oct 22; 126(17):2031-7. Kautz L, Jung G, Du X, Gabayan V, Chapman J, Nasoff M, Nemeth E, Ganz T. PMID: 26276665; PMCID: PMC4616236.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    97. Iron homeostasis in host defence and inflammation. Nat Rev Immunol. 2015 Aug; 15(8):500-10. Ganz T, Nemeth E. PMID: 26160612; PMCID: PMC4801113.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    98. Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver. Exp Hematol. 2015 Jun; 43(6):469-78.e6. Keel SB, Doty R, Liu L, Nemeth E, Cherian S, Ganz T, Abkowitz JL. PMID: 25782630; PMCID: PMC4771411.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    99. Small cyclic agonists of iron regulatory hormone hepcidin. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4961-4969. Chua K, Fung E, Micewicz ED, Ganz T, Nemeth E, Ruchala P. PMID: 25813158; PMCID: PMC4567957.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    100. Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus. Cell Host Microbe. 2015 Jan 14; 17(1):47-57. Arezes J, Jung G, Gabayan V, Valore E, Ruchala P, Gulig PA, Ganz T, Nemeth E, Bulut Y. PMID: 25590758; PMCID: PMC4296238.
      View in: PubMed   Mentions: 92  Translation:AnimalsCells
    101. Thiol-derivatized minihepcidins retain biological activity. Bioorg Med Chem Lett. 2015 Feb 15; 25(4):763-6. Fung E, Chua K, Ganz T, Nemeth E, Ruchala P. PMID: 25599838; PMCID: PMC4318710.
      View in: PubMed   Mentions: 9     Fields:    
    102. Hepcidin and the global burden of iron deficiency. Clin Chem. 2015 Apr; 61(4):577-8. Ganz T. PMID: 25492087.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    103. A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis. Haematologica. 2015 Feb; 100(2):167-77. Gutschow P, Schmidt PJ, Han H, Ostland V, Bartnikas TB, Pettiglio MA, Herrera C, Butler JS, Nemeth E, Ganz T, Fleming MD, Westerman M. PMID: 25425686; PMCID: PMC4803145.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    104. The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study. Haematologica. 2015 Jan; 100(1):124-32. Macciò A, Madeddu C, Gramignano G, Mulas C, Tanca L, Cherchi MC, Floris C, Omoto I, Barracca A, Ganz T. PMID: 25239265; PMCID: PMC4281325.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    105. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014 Oct 16; 124(16):2569-74. Kautz L, Jung G, Nemeth E, Ganz T. PMID: 25193872; PMCID: PMC4199959.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    106. Disordered hepcidin-ferroportin signaling promotes breast cancer growth. Cell Signal. 2014 Nov; 26(11):2539-50. Zhang S, Chen Y, Guo W, Yuan L, Zhang D, Xu Y, Nemeth E, Ganz T, Liu S. PMID: 25093806.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    107. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014 Jul; 46(7):678-84. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. PMID: 24880340; PMCID: PMC4104984.
      View in: PubMed   Mentions: 315     Fields:    Translation:Animals
    108. Anemia of inflammation. Hematol Oncol Clin North Am. 2014 Aug; 28(4):671-81, vi. Nemeth E, Ganz T. PMID: 25064707; PMCID: PMC4115203.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    109. Mouse models of anemia of cancer. PLoS One. 2014; 9(3):e93283. Kim A, Rivera S, Shprung D, Limbrick D, Gabayan V, Nemeth E, Ganz T. PMID: 24681760; PMCID: PMC3969362.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    110. A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood. 2014 Feb 20; 123(8):1129-36. Kim A, Fung E, Parikh SG, Valore EV, Gabayan V, Nemeth E, Ganz T. PMID: 24357728.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    111. Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology. 2014 Feb; 59(2):683-94. Latour C, Kautz L, Besson-Fournier C, Island ML, Canonne-Hergaux F, Loréal O, Ganz T, Coppin H, Roth MP. PMID: 23907767.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    112. Testing the iron hypothesis in a mouse model of atherosclerosis. Cell Rep. 2013 Dec 12; 5(5):1436-42. Kautz L, Gabayan V, Wang X, Wu J, Onwuzurike J, Jung G, Qiao B, Lusis AJ, Ganz T, Nemeth E. PMID: 24316081; PMCID: PMC3880128.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    113. Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc. Am J Physiol Cell Physiol. 2014 Mar 01; 306(5):C450-9. Mitchell CJ, Shawki A, Ganz T, Nemeth E, Mackenzie B. PMID: 24304836; PMCID: PMC4042619.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    114. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infect Immun. 2014 Feb; 82(2):745-52. Rodriguez R, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y. PMID: 24478088; PMCID: PMC3911381.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    115. Systemic iron homeostasis. Physiol Rev. 2013 Oct; 93(4):1721-41. Ganz T. PMID: 24137020.
      View in: PubMed   Mentions: 266     Fields:    Translation:HumansCells
    116. Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers. 2013 Sep; 100(5):519-26. Clark RJ, Preza GC, Tan CC, van Dijk JW, Fung E, Nemeth E, Ganz T, Craik DJ. PMID: 23897622.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    117. Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age. Haematologica. 2013 Oct; 98(10):1633-40. McCranor BJ, Langdon JM, Prince OD, Femnou LK, Berger AE, Cheadle C, Civin CI, Kim A, Rivera S, Ganz T, Vaulont S, Xue QL, Walston JD, Roy CN. PMID: 23996485; PMCID: PMC3789470.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    118. Cellular catabolism of the iron-regulatory peptide hormone hepcidin. PLoS One. 2013; 8(3):e58934. Preza GC, Pinon R, Ganz T, Nemeth E. PMID: 23536837; PMCID: PMC3594189.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    119. Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy. Haematologica. 2013 Aug; 98(8):1324-30. Mast AE, Schlumpf KS, Wright DJ, Johnson B, Glynn SA, Busch MP, Olbina G, Westerman M, Nemeth E, Ganz T, NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II). PMID: 23445875; PMCID: PMC3729915.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    120. High-throughput screening of small molecules identifies hepcidin antagonists. Mol Pharmacol. 2013 Mar; 83(3):681-90. Fung E, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E. PMID: 23292796; PMCID: PMC3583499.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    121. Preface: iron and cancer. Crit Rev Oncog. 2013; 18(5):preceding 391. Ganz T. PMID: 23879592.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    122. Hepcidin is a key mediator of anemia of inflammation in Crohn's disease. J Crohns Colitis. 2013 Sep; 7(8):e286-91. Basseri RJ, Nemeth E, Vassilaki ME, Basseri B, Enayati P, Shaye O, Bourikas LA, Ganz T, Papadakis KA. PMID: 23219355.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    123. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood. 2012 Nov 01; 120(18):3829-36. Ramos E, Ruchala P, Goodnough JB, Kautz L, Preza GC, Nemeth E, Ganz T. PMID: 22990014; PMCID: PMC3488893.
      View in: PubMed   Mentions: 77     Fields:    Translation:Animals
    124. Iron homeostasis and its disorders in mice and men: potential lessons for rhinos. J Zoo Wildl Med. 2012 Sep; 43(3 Suppl):S19-26. Ganz T, Nemeth E. PMID: 23156702.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    125. IOD in rhinos--immunity group report: report from the Immunity, Genetics and Toxicology Working Group of the International Workshop on Iron Overload Disorder in Browsing Rhinoceros (February 2011). J Zoo Wildl Med. 2012 Sep; 43(3 Suppl):S117-9. Ganz T, Goff J, Klasing K, Nemeth E, Roth T. PMID: 23156715.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    126. Inhibition of hepcidin transcription by growth factors. Hepatology. 2012 Jul; 56(1):291-9. Goodnough JB, Ramos E, Nemeth E, Ganz T. PMID: 22278715; PMCID: PMC3362690.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    127. Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT. Cell Metab. 2012 Jun 06; 15(6):905-17. Ross SL, Tran L, Winters A, Lee KJ, Plewa C, Foltz I, King C, Miranda LP, Allen J, Beckman H, Cooke KS, Moody G, Sasu BJ, Nemeth E, Ganz T, Molineux G, Arvedson TL. PMID: 22682226.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    128. Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab. 2012 Jun 06; 15(6):918-24. Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E. PMID: 22682227; PMCID: PMC3372862.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    129. Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood. 2012 Jul 12; 120(2):431-9. Besson-Fournier C, Latour C, Kautz L, Bertrand J, Ganz T, Roth MP, Coppin H. PMID: 22611157.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    130. Hepcidin expression in iron overload diseases is variably modulated by circulating factors. PLoS One. 2012; 7(5):e36425. Ravasi G, Pelucchi S, Trombini P, Mariani R, Tomosugi N, Modignani GL, Pozzi M, Nemeth E, Ganz T, Hayashi H, Barisani D, Piperno A. PMID: 22586470; PMCID: PMC3346721.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    131. Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harb Perspect Med. 2012 May; 2(5):a011668. Ganz T, Nemeth E. PMID: 22553501; PMCID: PMC3331689.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    132. Macrophages and systemic iron homeostasis. J Innate Immun. 2012; 4(5-6):446-53. Ganz T. PMID: 22441209; PMCID: PMC6741611.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    133. Hepcidin and iron homeostasis. Biochim Biophys Acta. 2012 Sep; 1823(9):1434-43. Ganz T, Nemeth E. PMID: 22306005; PMCID: PMC4048856.
      View in: PubMed   Mentions: 349     Fields:    Translation:HumansAnimalsCells
    134. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest. 2011 Dec; 121(12):4880-8. Preza GC, Ruchala P, Pinon R, Ramos E, Qiao B, Peralta MA, Sharma S, Waring A, Ganz T, Nemeth E. PMID: 22045566; PMCID: PMC3225996.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    135. Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. Blood. 2011 Nov 10; 118(19):5278-82. Gordeuk VR, Miasnikova GY, Sergueeva AI, Niu X, Nouraie M, Okhotin DJ, Polyakova LA, Ammosova T, Nekhai S, Ganz T, Prchal JT. PMID: 21876117; PMCID: PMC3217409.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    136. The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia. Haematologica. 2011 Sep; 96(9):1371-4. Miasnikova GY, Sergueeva AI, Nouraie M, Niu X, Okhotin DJ, Polyakova LA, Ganz T, Prchal JT, Gordeuk VR. PMID: 21606165; PMCID: PMC3166109.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    137. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica. 2011 Aug; 96(8):1099-105. Pasricha SR, McQuilten Z, Westerman M, Keller A, Nemeth E, Ganz T, Wood E. PMID: 21508121; PMCID: PMC3148902.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    138. Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome. Liver Int. 2011 Aug; 31(7):994-1000. Trombini P, Paolini V, Pelucchi S, Mariani R, Nemeth E, Ganz T, Piperno A. PMID: 21733088; PMCID: PMC4048852.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    139. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology. 2011 Apr; 53(4):1333-41. Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, Roth MP, Nemeth E, Ganz T. PMID: 21480335; PMCID: PMC3074982.
      View in: PubMed   Mentions: 92     Fields:    Translation:Animals
    140. Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chem Biol. 2011 Mar 25; 18(3):336-43. Clark RJ, Tan CC, Preza GC, Nemeth E, Ganz T, Craik DJ. PMID: 21439478; PMCID: PMC3073735.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    141. Hepcidin and iron regulation, 10 years later. Blood. 2011 Apr 28; 117(17):4425-33. Ganz T. PMID: 21346250; PMCID: PMC3099567.
      View in: PubMed   Mentions: 262     Fields:    Translation:Humans
    142. Increased serum hepcidin levels during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndrome. Br J Haematol. 2011 Apr; 153(1):118-20. Ghoti H, Fibach E, Westerman M, Gordana O, Ganz T, Rachmilewitz EA. PMID: 21332711.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    143. Hepcidin and disorders of iron metabolism. Annu Rev Med. 2011; 62:347-60. Ganz T, Nemeth E. PMID: 20887198.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansAnimalsCells
    144. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematology Am Soc Hematol Educ Program. 2011; 2011:538-42. Ganz T, Nemeth E. PMID: 22160086; PMCID: PMC4034574.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    145. A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis. Haematologica. 2011 Apr; 96(4):500-6. Girelli D, Trombini P, Busti F, Campostrini N, Sandri M, Pelucchi S, Westerman M, Ganz T, Nemeth E, Piperno A, Camaschella C. PMID: 21173098; PMCID: PMC3069225.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    146. Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood. 2011 Mar 10; 117(10):2953-9. Piperno A, Galimberti S, Mariani R, Pelucchi S, Ravasi G, Lombardi C, Bilo G, Revera M, Giuliano A, Faini A, Mainini V, Westerman M, Ganz T, Valsecchi MG, Mancia G, Parati G, HIGHCARE investigators. PMID: 21149632.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    147. Detection, evaluation, and management of iron-restricted erythropoiesis. Blood. 2010 Dec 02; 116(23):4754-61. Goodnough LT, Nemeth E, Ganz T. PMID: 20826717.
      View in: PubMed   Mentions: 114     Fields:    Translation:Humans
    148. In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. Blood. 2010 Nov 04; 116(18):3635-44. Maes K, Nemeth E, Roodman GD, Huston A, Esteve F, Freytes C, Callander N, Katodritou E, Tussing-Humphreys L, Rivera S, Vanderkerken K, Lichtenstein A, Ganz T. PMID: 20679527; PMCID: PMC2981483.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    149. Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. J Clin Endocrinol Metab. 2010 Oct; 95(10):4743-7. Bachman E, Feng R, Travison T, Li M, Olbina G, Ostland V, Ulloor J, Zhang A, Basaria S, Ganz T, Westerman M, Bhasin S. PMID: 20660052; PMCID: PMC3050108.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    150. Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population. Anesthesiology. 2010 Jun; 112(6):1428-34. Chen Q, Hakimi M, Wu S, Jin Y, Cheng B, Wang H, Xie G, Ganz T, Linzmeier RM, Fang X. PMID: 20502117.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    151. Alpha 1-acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium. Am J Clin Nutr. 2010 Jun; 91(6):1784-90. Ayoya MA, Spiekermann-Brouwer GM, Stoltzfus RJ, Nemeth E, Habicht JP, Ganz T, Rawat R, Traoré AK, Garza C. PMID: 20410090.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    152. Reduction of serum hepcidin by hemodialysis in pediatric and adult patients. Clin J Am Soc Nephrol. 2010 Jun; 5(6):1010-4. Zaritsky J, Young B, Gales B, Wang HJ, Rastogi A, Westerman M, Nemeth E, Ganz T, Salusky IB. PMID: 20299375; PMCID: PMC2879302.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    153. Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier. Am J Respir Crit Care Med. 2010 May 01; 181(9):935-46. Bdeir K, Higazi AA, Kulikovskaya I, Christofidou-Solomidou M, Vinogradov SA, Allen TC, Idell S, Linzmeier R, Ganz T, Cines DB. PMID: 20093642; PMCID: PMC2862305.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    154. Proinflammatory state, hepcidin, and anemia in older persons. Blood. 2010 May 06; 115(18):3810-6. Ferrucci L, Semba RD, Guralnik JM, Ershler WB, Bandinelli S, Patel KV, Sun K, Woodman RC, Andrews NC, Cotter RJ, Ganz T, Nemeth E, Longo DL. PMID: 20081092; PMCID: PMC2865871.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    155. Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica. 2009 Dec; 94(12):1748-52. Kroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, Swinkels DW. PMID: 19996119; PMCID: PMC2791950.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    156. The role of hepcidin in iron metabolism. Acta Haematol. 2009; 122(2-3):78-86. Nemeth E, Ganz T. PMID: 19907144; PMCID: PMC2855274.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    157. Animal models of anemia of inflammation. Semin Hematol. 2009 Oct; 46(4):351-7. Rivera S, Ganz T. PMID: 19786203; PMCID: PMC2755601.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    158. Iron sequestration and anemia of inflammation. Semin Hematol. 2009 Oct; 46(4):387-93. Ganz T, Nemeth E. PMID: 19786207; PMCID: PMC2755591.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    159. [Hepcidin and Plasmodium falciparum malaria in anemic school children in Mali]. Bull Soc Pathol Exot. 2009 Oct; 102(4):219-20. Ayoya MA, Stoltzfus RJ, Spiekermann-Brouwer GM, Nemeth E, Traoré AK, Ganz T, Garza C. PMID: 19950537.
      View in: PubMed   Mentions:
    160. Reduced serum hepcidin levels in patients with chronic hepatitis C. J Hepatol. 2009 Nov; 51(5):845-52. Girelli D, Pasino M, Goodnough JB, Nemeth E, Guido M, Castagna A, Busti F, Campostrini N, Martinelli N, Vantini I, Corrocher R, Ganz T, Fattovich G. PMID: 19729219; PMCID: PMC2761995.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    161. Sequential evaluation of serum hepcidin in anemic myeloma patients: study of correlations with myeloma treatment, disease variables, and anemia response. Am J Hematol. 2009 Aug; 84(8):524-6. Katodritou E, Ganz T, Terpos E, Verrou E, Olbina G, Gastari V, Hadjiaggelidou C, Varthaliti M, Georgiadou S, Westerman M, Zervas K. PMID: 19536845.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    162. Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation. Blood. 2009 Jul 09; 114(2):493-4. Sham RL, Phatak PD, Nemeth E, Ganz T. PMID: 19589941; PMCID: PMC2714220.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    163. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 2009 Jul 02; 114(1):181-6. Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL. PMID: 19414861; PMCID: PMC2710947.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    164. Hepcidin--a potential novel biomarker for iron status in chronic kidney disease. Clin J Am Soc Nephrol. 2009 Jun; 4(6):1051-6. Zaritsky J, Young B, Wang HJ, Westerman M, Olbina G, Nemeth E, Ganz T, Rivera S, Nissenson AR, Salusky IB. PMID: 19406957; PMCID: PMC2689881.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCTClinical Trials
    165. The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood. 2009 Jul 09; 114(2):437-43. Fernandes A, Preza GC, Phung Y, De Domenico I, Kaplan J, Ganz T, Nemeth E. PMID: 19383972; PMCID: PMC2714214.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    166. Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. J Hepatol. 2009 Jun; 50(6):1219-25. Ruivard M, Lainé F, Ganz T, Olbina G, Westerman M, Nemeth E, Rambeau M, Mazur A, Gerbaud L, Tournilhac V, Abergel A, Philippe P, Deugnier Y, Coudray C. PMID: 19398238.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    167. Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism. Eur J Appl Physiol. 2009 Jun; 106(3):435-43. Troadec MB, Lainé F, Daniel V, Rochcongar P, Ropert M, Cabillic F, Perrin M, Morcet J, Loréal O, Olbina G, Westerman M, Nemeth E, Ganz T, Brissot P. PMID: 19306018.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    168. Iron in innate immunity: starve the invaders. Curr Opin Immunol. 2009 Feb; 21(1):63-7. Ganz T. PMID: 19231148; PMCID: PMC2668730.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimals
    169. Differential Processing of {alpha}- and {beta}-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7). J Biol Chem. 2009 Mar 27; 284(13):8301-11. Wilson CL, Schmidt AP, Pirilä E, Valore EV, Ferri N, Sorsa T, Ganz T, Parks WC. PMID: 19181662; PMCID: PMC2659188.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    170. Immunoassay for human serum hepcidin. Blood. 2008 Nov 15; 112(10):4292-7. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. PMID: 18689548.
      View in: PubMed   Mentions: 228     Fields:    Translation:Humans
    171. The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab. 2008 Aug; 8(2):146-56. De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J. PMID: 18680715; PMCID: PMC2660598.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    172. Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res. 2008 Jun 01; 14(11):3262-7. Sharma S, Nemeth E, Chen YH, Goodnough J, Huston A, Roodman GD, Ganz T, Lichtenstein A. PMID: 18519751.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    173. Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis. Br J Haematol. 2008 Aug; 142(4):669-71. Winder A, Lefkowitz R, Ghoti H, Leiba M, Ganz T, Nemeth E, Rachmilewitz EA. PMID: 18498424.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    174. Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload. J Hepatol. 2008 Jul; 49(1):123-33. Barisani D, Pelucchi S, Mariani R, Galimberti S, Trombini P, Fumagalli D, Meneveri R, Nemeth E, Ganz T, Piperno A. PMID: 18462824.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    175. Iron homeostasis: fitting the puzzle pieces together. Cell Metab. 2008 Apr; 7(4):288-90. Ganz T. PMID: 18396134.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    176. Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. Blood Cells Mol Dis. 2008 May-Jun; 40(3):347-52. Bozzini C, Campostrini N, Trombini P, Nemeth E, Castagna A, Tenuti I, Corrocher R, Camaschella C, Ganz T, Olivieri O, Piperno A, Girelli D. PMID: 18164223.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    177. Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest. 2007 Nov; 117(11):3339-49. Aberg KM, Radek KA, Choi EH, Kim DK, Demerjian M, Hupe M, Kerbleski J, Gallo RL, Ganz T, Mauro T, Feingold KR, Elias PM. PMID: 17975669; PMCID: PMC2045593.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    178. Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol. 2008 Apr; 128(4):917-25. Aberg KM, Man MQ, Gallo RL, Ganz T, Crumrine D, Brown BE, Choi EH, Kim DK, Schröder JM, Feingold KR, Elias PM. PMID: 17943185; PMCID: PMC2671223.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    179. Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia. Haematologica. 2007 Oct; 92(10):1407-10. Trombini P, Coliva T, Nemeth E, Mariani R, Ganz T, Biondi A, Piperno A. PMID: 17768112.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    180. Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol Dis. 2008 Jan-Feb; 40(1):132-8. Valore EV, Ganz T. PMID: 17905609; PMCID: PMC2211381.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    181. Functional analysis of the host defense peptide Human Beta Defensin-1: new insight into its potential role in cancer. Mol Immunol. 2008 Feb; 45(3):839-48. Bullard RS, Gibson W, Bose SK, Belgrave JK, Eaddy AC, Wright CJ, Hazen-Martin DJ, Lage JM, Keane TE, Ganz TA, Donald CD. PMID: 17868871; PMCID: PMC2131727.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    182. Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis. 2008 Jan-Feb; 40(1):122-31. Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T. PMID: 17869549; PMCID: PMC2211380.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    183. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood. 2007 Dec 01; 110(12):4096-100. Piperno A, Girelli D, Nemeth E, Trombini P, Bozzini C, Poggiali E, Phung Y, Ganz T, Camaschella C. PMID: 17724144.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    184. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007 Sep; 13(9):1096-101. Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, Moroney JW, Reed CH, Luban NL, Wang RH, Eling TE, Childs R, Ganz T, Leitman SF, Fucharoen S, Miller JL. PMID: 17721544.
      View in: PubMed   Mentions: 273     Fields:    Translation:HumansCells
    185. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007 Sep 15; 110(6):2182-9. Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. PMID: 17540841; PMCID: PMC1976373.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    186. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell. 2007 Jul; 18(7):2569-78. De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J. PMID: 17475779; PMCID: PMC1924807.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    187. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica. 2007 May; 92(5):583-8. Origa R, Galanello R, Ganz T, Giagu N, Maccioni L, Faa G, Nemeth E. PMID: 17488680.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    188. Molecular control of iron transport. J Am Soc Nephrol. 2007 Feb; 18(2):394-400. Ganz T. PMID: 17229910.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    189. Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer. 2007 Jan; 48(1):57-63. Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein DA, Cunningham MJ. PMID: 16220548.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCTClinical Trials
    190. Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect Immun. 2006 Oct; 74(10):5693-702. Valore EV, Wiley DJ, Ganz T. PMID: 16988245; PMCID: PMC1594936.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    191. Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. J Immunol. 2006 Aug 01; 177(3):1864-71. Tan BH, Meinken C, Bastian M, Bruns H, Legaspi A, Ochoa MT, Krutzik SR, Bloom BR, Ganz T, Modlin RL, Stenger S. PMID: 16849498.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    192. Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica. 2006 Aug; 91(8):1092-5. De Domenico I, McVey Ward D, Nemeth E, Ganz T, Corradini E, Ferrara F, Musci G, Pietrangelo A, Kaplan J. PMID: 16885049; PMCID: PMC3718284.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    193. Suppression of hepcidin during anemia requires erythropoietic activity. Blood. 2006 Dec 01; 108(12):3730-5. Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. PMID: 16882706; PMCID: PMC1895477.
      View in: PubMed   Mentions: 181     Fields:    Translation:Animals
    194. DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis. Blood. 2006 Jul 01; 108(1):404-5. Pospisilova D, Mims MP, Nemeth E, Ganz T, Prchal JT. PMID: 16790587; PMCID: PMC1895846.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    195. Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. J Clin Invest. 2006 Jul; 116(7):1878-85. Sørensen OE, Thapa DR, Roupé KM, Valore EV, Sjöbring U, Roberts AA, Schmidtchen A, Ganz T. PMID: 16778986; PMCID: PMC1479426.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    196. Hepcidin and iron-loading anemias. Haematologica. 2006 Jun; 91(6):727-32. Nemeth E, Ganz T. PMID: 16769573.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    197. Regulation of iron acquisition and iron distribution in mammals. Biochim Biophys Acta. 2006 Jul; 1763(7):690-9. Ganz T, Nemeth E. PMID: 16790283.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    198. Molecular pathogenesis of anemia of chronic disease. Pediatr Blood Cancer. 2006 May 01; 46(5):554-7. Ganz T. PMID: 16261603.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    199. Copy number polymorphisms are not a common feature of innate immune genes. Genomics. 2006 Jul; 88(1):122-6. Linzmeier RM, Ganz T. PMID: 16617005.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    200. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol. 2006 Feb; 290(2):G199-203. Ganz T, Nemeth E. PMID: 16407589.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    201. Hepcidin--a peptide hormone at the interface of innate immunity and iron metabolism. Curr Top Microbiol Immunol. 2006; 306:183-98. Ganz T. PMID: 16909922.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    202. Hepcidin and its role in regulating systemic iron metabolism. Hematology Am Soc Hematol Educ Program. 2006; 29-35, 507. Ganz T. PMID: 17124036.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    203. Regulation of iron metabolism by hepcidin. Annu Rev Nutr. 2006; 26:323-42. Nemeth E, Ganz T. PMID: 16848710.
      View in: PubMed   Mentions: 205     Fields:    Translation:Humans
    204. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18129-34. Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, Stange EF, Bevins CL. PMID: 16330776; PMCID: PMC1306791.
      View in: PubMed   Mentions: 311     Fields:    Translation:HumansAnimalsCells
    205. Iron-regulatory protein hepcidin is increased in female athletes after a marathon. Eur J Appl Physiol. 2005 Dec; 95(5-6):569-71. Roecker L, Meier-Buttermilch R, Brechtel L, Nemeth E, Ganz T. PMID: 16249921.
      View in: PubMed   Mentions:
    206. A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron. Blood. 2005 Oct 15; 106(8):2922-3. Porto G, Roetto A, Daraio F, Pinto JP, Almeida S, Bacelar C, Nemeth E, Ganz T, Camaschella C. PMID: 16204153.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    207. Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M. J Leukoc Biol. 2005 Nov; 78(5):1081-5. Cole AM, Thapa DR, Gabayan V, Liao HI, Liu L, Ganz T. PMID: 16204648.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    208. Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. Genomics. 2005 Oct; 86(4):423-30. Linzmeier RM, Ganz T. PMID: 16039093.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    209. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood. 2006 Jan 01; 107(1):328-33. Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T. PMID: 16141345; PMCID: PMC1895343.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    210. Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infect Immun. 2005 Aug; 73(8):4823-33. Porter E, Yang H, Yavagal S, Preza GC, Murillo O, Lima H, Greene S, Mahoozi L, Klein-Patel M, Diamond G, Gulati S, Ganz T, Rice PA, Quayle AJ. PMID: 16040996; PMCID: PMC1201278.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    211. Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease. Hepatology. 2005 Aug; 42(2):466-72. Zoller H, McFarlane I, Theurl I, Stadlmann S, Nemeth E, Oxley D, Ganz T, Halsall DJ, Cox TM, Vogel W. PMID: 15986403.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    212. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood. 2005 Oct 15; 106(8):2884-9. Lin L, Goldberg YP, Ganz T. PMID: 15998830.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    213. Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract. J Clin Pathol. 2005 Jul; 58(7):687-94. Shen B, Porter EM, Reynoso E, Shen C, Ghosh D, Connor JT, Drazba J, Rho HK, Gramlich TL, Li R, Ormsby AH, Sy MS, Ganz T, Bevins CL. PMID: 15976333; PMCID: PMC1770712.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    214. The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):8955-60. De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J. PMID: 15956209; PMCID: PMC1157058.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    215. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood. 2005 Sep 15; 106(6):2196-9. Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. PMID: 15933050; PMCID: PMC1895137.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    216. Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol. 2005 Jun; 18(2):171-82. Ganz T. PMID: 15737883.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    217. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol. 2005 May 15; 174(10):6137-43. Miller LS, Sørensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, Chung W, Starner TD, Kim J, Sieling PA, Ganz T, Modlin RL. PMID: 15879109.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    218. Defensins and other antimicrobial peptides: a historical perspective and an update. Comb Chem High Throughput Screen. 2005 May; 8(3):209-17. Ganz T. PMID: 15892623.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    219. Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6843-8. Liuzzi JP, Lichten LA, Rivera S, Blanchard RK, Aydemir TB, Knutson MD, Ganz T, Cousins RJ. PMID: 15863613; PMCID: PMC1100791.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCells
    220. Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol. 2005 Apr 15; 174(8):4870-9. Sørensen OE, Thapa DR, Rosenthal A, Liu L, Roberts AA, Ganz T. PMID: 15814714.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    221. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood. 2005 Jul 15; 106(2):746-8. Détivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, Ropert M, Jacquelinet S, Courselaud B, Ganz T, Brissot P, Loréal O. PMID: 15797999.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    222. Cellular iron: ferroportin is the only way out. Cell Metab. 2005 Mar; 1(3):155-7. Ganz T. PMID: 16054057.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    223. Hepcidin in iron overload disorders. Blood. 2005 May 15; 105(10):4103-5. Papanikolaou G, Tzilianos M, Christakis JI, Bogdanos D, Tsimirika K, MacFarlane J, Goldberg YP, Sakellaropoulos N, Ganz T, Nemeth E. PMID: 15671438; PMCID: PMC1895089.
      View in: PubMed   Mentions: 122     Fields:    Translation:Humans
    224. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004 Dec 17; 306(5704):2090-3. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. PMID: 15514116.
      View in: PubMed   Mentions: 1426     Fields:    Translation:HumansAnimalsCells
    225. Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation. Transplantation. 2004 Oct 27; 78(8):1222-4. Ross DJ, Cole AM, Yoshioka D, Park AK, Belperio JA, Laks H, Strieter RM, Lynch JP, Kubak B, Ardehali A, Ganz T. PMID: 15502724.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    226. Hepcidin is decreased in TFR2 hemochromatosis. Blood. 2005 Feb 15; 105(4):1803-6. Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. PMID: 15486069.
      View in: PubMed   Mentions: 138     Fields:    Translation:Humans
    227. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood. 2005 Feb 15; 105(4):1797-802. Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T. PMID: 15479721.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    228. Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis. Ann Allergy Asthma Immunol. 2004 Sep; 93(3):288-92. Kalfa VC, Spector SL, Ganz T, Cole AM. PMID: 15478391.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    229. Hepcidin in iron metabolism. Curr Opin Hematol. 2004 Jul; 11(4):251-4. Ganz T. PMID: 15314524.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    230. Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP gene. Blood. 2004 Oct 01; 104(7):2181-3. Matthes T, Aguilar-Martinez P, Pizzi-Bosman L, Darbellay R, Rubbia-Brandt L, Giostra E, Michel M, Ganz T, Beris P. PMID: 15198949.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    231. Defensins: antimicrobial peptides of vertebrates. C R Biol. 2004 Jun; 327(6):539-49. Ganz T. PMID: 15330253.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    232. Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae. BMC Infect Dis. 2004 May 05; 4:12. Lee HY, Andalibi A, Webster P, Moon SK, Teufert K, Kang SH, Li JD, Nagura M, Ganz T, Lim DJ. PMID: 15125783; PMCID: PMC428576.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    233. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004 May; 113(9):1271-6. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. PMID: 15124018; PMCID: PMC398432.
      View in: PubMed   Mentions: 721     Fields:    Translation:HumansAnimalsCells
    234. Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol. 2003 Dec 15; 171(12):6820-6. Hertz CJ, Wu Q, Porter EM, Zhang YJ, Weismüller KH, Godowski PJ, Ganz T, Randell SH, Modlin RL. PMID: 14662888.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    235. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004 Jan; 36(1):77-82. Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dubé MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, Radomski CC, Pape TD, Davidas O, Christakis J, Brissot P, Lockitch G, Ganz T, Hayden MR, Goldberg YP. PMID: 14647275.
      View in: PubMed   Mentions: 271     Fields:    Translation:HumansCells
    236. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol. 2003 Sep; 3(9):710-20. Ganz T. PMID: 12949495.
      View in: PubMed   Mentions: 857     Fields:    Translation:HumansAnimalsCells
    237. Inducibility of HBD-2 in acute burns and chronic conditions of the lung. Burns. 2003 Sep; 29(6):553-5. Milner SM, Cole A, Ortega MR, Bakir MH, Gulati S, Bhat S, Ganz T. PMID: 12927979.
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    238. Antimicrobial polypeptides. J Leukoc Biol. 2004 Jan; 75(1):34-8. Ganz T. PMID: 12960278.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    239. Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J Immunol. 2003 Jun 01; 170(11):5583-9. Sørensen OE, Cowland JB, Theilgaard-Mönch K, Liu L, Ganz T, Borregaard N. PMID: 12759437.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    240. Microbiology: Gut defence. Nature. 2003 Apr 03; 422(6931):478-9. Ganz T. PMID: 12673233.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    241. Cancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas. Lab Invest. 2003 Apr; 83(4):501-5. Donald CD, Sun CQ, Lim SD, Macoska J, Cohen C, Amin MB, Young AN, Ganz TA, Marshall FF, Petros JA. PMID: 12695553.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    242. The role of antimicrobial peptides in innate immunity. Integr Comp Biol. 2003 Apr; 43(2):300-4. Ganz T. PMID: 21680437.
      View in: PubMed   Mentions: 68  
    243. In human epidermis, beta-defensin 2 is packaged in lamellar bodies. Exp Mol Pathol. 2003 Apr; 74(2):180-2. Oren A, Ganz T, Liu L, Meerloo T. PMID: 12710950.
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    244. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 2003 Aug 01; 102(3):783-8. Ganz T. PMID: 12663437.
      View in: PubMed   Mentions: 327     Fields:    Translation:Humans
    245. Angiogenin: an antimicrobial ribonuclease. Nat Immunol. 2003 Mar; 4(3):213-4. Ganz T. PMID: 12605229.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    246. Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1. FEBS Lett. 2003 Jan 30; 535(1-3):195-9. Cole AM, Liao HI, Ganz T, Yang OO. PMID: 12560103.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    247. Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans. Biol Reprod. 2003 Jan; 68(1):95-104. Com E, Bourgeon F, Evrard B, Ganz T, Colleu D, Jégou B, Pineau C. PMID: 12493700.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    248. By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J Immunol. 2003 Jan 01; 170(1):575-80. Liu L, Roberts AA, Ganz T. PMID: 12496445.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    249. Cationic polypeptides are required for antibacterial activity of human airway fluid. J Immunol. 2002 Dec 15; 169(12):6985-91. Cole AM, Liao HI, Stuchlik O, Tilan J, Pohl J, Ganz T. PMID: 12471133.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    250. A model for antimicrobial gene therapy: demonstration of human beta-defensin 2 antimicrobial activities in vivo. Hum Gene Ther. 2002 Nov 20; 13(17):2017-25. Huang GT, Zhang HB, Kim D, Liu L, Ganz T. PMID: 12489997; PMCID: PMC1790959.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    251. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003 Apr 01; 101(7):2461-3. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. PMID: 12433676.
      View in: PubMed   Mentions: 386     Fields:    Translation:HumansCells
    252. Immunology. Versatile defensins. Science. 2002 Nov 01; 298(5595):977-9. Ganz T. PMID: 12411693.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    253. The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic disease. Isr Med Assoc J. 2002 Nov; 4(11):1043-5. Ganz T. PMID: 12489503.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    254. Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan. Blood. 2003 Mar 15; 101(6):2388-92. Ganz T, Gabayan V, Liao HI, Liu L, Oren A, Graf T, Cole AM. PMID: 12411294.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    255. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med. 2002 Oct 10; 347(15):1151-60. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, Gallo RL, Leung DY. PMID: 12374875.
      View in: PubMed   Mentions: 483     Fields:    Translation:HumansCells
    256. Antimicrobial components of vaginal fluid. Am J Obstet Gynecol. 2002 Sep; 187(3):561-8. Valore EV, Park CH, Igreti SL, Ganz T. PMID: 12237628.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    257. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem. 2002 Oct 04; 277(40):37597-603. Hunter HN, Fulton DB, Ganz T, Vogel HJ. PMID: 12138110.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    258. Antimicrobial factors in the cervical mucus plug. Am J Obstet Gynecol. 2002 Jul; 187(1):137-44. Hein M, Valore EV, Helmig RB, Uldbjerg N, Ganz T. PMID: 12114901.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    259. Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells. Biochim Biophys Acta. 2002 Jun 12; 1590(1-3):41-51. Moon SK, Lee HY, Li JD, Nagura M, Kang SH, Chun YM, Linthicum FH, Ganz T, Andalibi A, Lim DJ. PMID: 12063167.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    260. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol. 2002 Jun; 3(6):583-90. Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL. PMID: 12021776.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    261. Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils. Transplantation. 2002 May 15; 73(9):1522-6. Levy O, Sisson RB, Fryer HE, Goldmann D, Valore E, Ganz T, White ML, Carroll SF, Lehmann L, Guinan EC. PMID: 12023636.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    262. Epithelia: not just physical barriers. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3357-8. Ganz T. PMID: 11904396; PMCID: PMC122525.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    263. Using a collaborative weaning plan to decrease duration of mechanical ventilation and length of stay in the intensive care unit for patients receiving long-term ventilation. Am J Crit Care. 2002 Mar; 11(2):132-40. Henneman E, Dracup K, Ganz T, Molayeme O, Cooper CB. PMID: 11888125.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    264. Antimicrobial polypeptides in host defense of the respiratory tract. J Clin Invest. 2002 Mar; 109(6):693-7. Ganz T. PMID: 11901174; PMCID: PMC150915.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    265. Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol. 2002 Feb; 118(2):275-81. Liu AY, Destoumieux D, Wong AV, Park CH, Valore EV, Liu L, Ganz T. PMID: 11841544.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    266. Defensins of vertebrate animals. Curr Opin Immunol. 2002 Feb; 14(1):96-102. Lehrer RI, Ganz T. PMID: 11790538.
      View in: PubMed   Mentions: 171     Fields:    Translation:Animals
    267. Overexpression and structural study of the cathelicidin motif of the protegrin-3 precursor. Biochemistry. 2002 Jan 08; 41(1):21-30. Sanchez JF, Wojcik F, Yang YS, Strub MP, Strub JM, Van Dorsselaer A, Martin M, Lehrer R, Ganz T, Chavanieu A, Calas B, Aumelas A. PMID: 11771999.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    268. Cathelicidins: a family of endogenous antimicrobial peptides. Curr Opin Hematol. 2002 Jan; 9(1):18-22. Lehrer RI, Ganz T. PMID: 11753073.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    269. Antimicrobial peptides and proteins in the CF airway. Methods Mol Med. 2002; 70:447-64. Cole AM, Ganz T. PMID: 11917542.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    270. The multifaceted Paneth cell. Cell Mol Life Sci. 2002 Jan; 59(1):156-70. Porter EM, Bevins CL, Ghosh D, Ganz T. PMID: 11846026.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    271. Determinants of Staphylococcus aureus nasal carriage. Clin Diagn Lab Immunol. 2001 Nov; 8(6):1064-9. Cole AM, Tahk S, Oren A, Yoshioka D, Kim YH, Park A, Ganz T. PMID: 11687441; PMCID: PMC96227.
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    272. Direct and indirect bacterial killing functions of neutrophil defensins in lung explants. Am J Physiol Lung Cell Mol Physiol. 2001 Nov; 281(5):L1240-7. Porro GA, Lee JH, de Azavedo J, Crandall I, Whitehead T, Tullis E, Ganz T, Liu M, Slutsky AS, Zhang H. PMID: 11597916.
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    273. Expression, purification, crystallization and preliminary X-ray analysis of the cathelicidin motif of the protegrin-3 precursor. Acta Crystallogr D Biol Crystallogr. 2001 Nov; 57(Pt 11):1677-9. Sanchez JF, Hoh F, Strub MP, Strub JM, Van Dorsselaer A, Lehrer R, Ganz T, Chavanieu A, Calas B, Dumas C, Aumelas A. PMID: 11679742.
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    274. Localized antimicrobial peptide expression in human gingiva. J Periodontal Res. 2001 Oct; 36(5):285-94. Dale BA, Kimball JR, Krisanaprakornkit S, Roberts F, Robinovitch M, O'Neal R, Valore EV, Ganz T, Anderson GM, Weinberg A. PMID: 11585115.
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    275. Detection of beta-defensins secreted by human oral epithelial cells. J Immunol Methods. 2001 Oct 01; 256(1-2):65-76. Diamond DL, Kimball JR, Krisanaprakornkit S, Ganz T, Dale BA. PMID: 11516756.
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    276. An in vitro study of antibacterial properties of the cervical mucus plug in pregnancy. Am J Obstet Gynecol. 2001 Sep; 185(3):586-92. Hein M, Helmig RB, Schønheyder HC, Ganz T, Uldbjerg N. PMID: 11568782.
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    277. Calcitermin, a novel antimicrobial peptide isolated from human airway secretions. FEBS Lett. 2001 Aug 24; 504(1-2):5-10. Cole AM, Kim YH, Tahk S, Hong T, Weis P, Waring AJ, Ganz T. PMID: 11522286.
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    278. Chemistry. Rings of destruction. Nature. 2001 Jul 26; 412(6845):392-3. Ganz T. PMID: 11473296.
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    279. Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J Immunol. 2001 Jul 15; 167(2):623-7. Cole AM, Ganz T, Liese AM, Burdick MD, Liu L, Strieter RM. PMID: 11441062.
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    280. Fatal attraction evaded. How pathogenic bacteria resist cationic polypeptides. J Exp Med. 2001 May 07; 193(9):F31-4. Ganz T. PMID: 11342596; PMCID: PMC2193427.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    281. The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment. Biochemistry. 2001 Apr 03; 40(13):3810-6. Sawai MV, Jia HP, Liu L, Aseyev V, Wiencek JM, McCray PB, Ganz T, Kearney WR, Tack BF. PMID: 11300761.
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    282. Antimicrobial proteins and peptides in host defense. Semin Respir Infect. 2001 Mar; 16(1):4-10. Ganz T. PMID: 11309707.
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    283. Defensins in the urinary tract and other tissues. J Infect Dis. 2001 Mar 01; 183 Suppl 1:S41-2. Ganz T. PMID: 11171012.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    284. Therapeutic effect of a pig-derived peptide antibiotic on porcine wound infections. Comp Med. 2001 Feb; 51(1):75-9. Ceccarelli AV, Cole AM, Park AK, Tahk S, Yoshioka D, Ganz T. PMID: 11926306.
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    285. Effect of a collaborative weaning plan on patient outcome in the critical care setting. Crit Care Med. 2001 Feb; 29(2):297-303. Henneman E, Dracup K, Ganz T, Molayeme O, Cooper C. PMID: 11246309.
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    286. Discovery of new human beta-defensins using a genomics-based approach. Gene. 2001 Jan 24; 263(1-2):211-8. Jia HP, Schutte BC, Schudy A, Linzmeier R, Guthmiller JM, Johnson GK, Tack BF, Mitros JP, Rosenthal A, Ganz T, McCray PB. PMID: 11223260.
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    287. Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds. Blood. 2001 Jan 01; 97(1):297-304. Cole AM, Shi J, Ceccarelli A, Kim YH, Park A, Ganz T. PMID: 11133774.
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    288. Granulysin, a T cell product, kills bacteria by altering membrane permeability. J Immunol. 2000 Dec 15; 165(12):7102-8. Ernst WA, Thoma-Uszynski S, Teitelbaum R, Ko C, Hanson DA, Clayberger C, Krensky AM, Leippe M, Bloom BR, Ganz T, Modlin RL. PMID: 11120840.
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    289. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001 Mar 16; 276(11):7806-10. Park CH, Valore EV, Waring AJ, Ganz T. PMID: 11113131.
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    290. Human beta defensin is absent in burn blister fluid. Burns. 2000 Dec; 26(8):724-6. Ortega MR, Ganz T, Milner SM. PMID: 11024605.
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    291. Human antimicrobial peptides: analysis and application. Biotechniques. 2000 Oct; 29(4):822-6, 828, 830-1. Cole AM, Ganz T. PMID: 11056814.
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    292. Regulation of human beta-defensins by gastric epithelial cells in response to infection with Helicobacter pylori or stimulation with interleukin-1. Infect Immun. 2000 Sep; 68(9):5412-5. O'Neil DA, Cole SP, Martin-Porter E, Housley MP, Liu L, Ganz T, Kagnoff MF. PMID: 10948173; PMCID: PMC101807.
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    293. The alpha-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis. Blood. 2000 Aug 15; 96(4):1393-8. Higazi AA, Nassar T, Ganz T, Rader DJ, Udassin R, Bdeir K, Hiss E, Sachais BS, Williams KJ, Leitersdorf E, Cines DB. PMID: 10942383.
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    294. Protegrins: new antibiotics of mammalian origin. Expert Opin Investig Drugs. 2000 Aug; 9(8):1731-42. Bellm L, Lehrer RI, Ganz T. PMID: 11060772.
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    295. Paneth cells--guardians of the gut cell hatchery. Nat Immunol. 2000 Aug; 1(2):99-100. Ganz T. PMID: 11248797.
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    296. Microanalysis of antimicrobial properties of human fluids. J Microbiol Methods. 2000 Jul; 41(2):135-43. Cole AM, Wu M, Kim YH, Ganz T. PMID: 10889310.
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    297. Beta-defensin expression in human mammary gland epithelia. Pediatr Res. 2000 Jul; 48(1):30-5. Tunzi CR, Harper PA, Bar-Oz B, Valore EV, Semple JL, Watson-MacDonell J, Ganz T, Ito S. PMID: 10879797.
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    298. Authors' corrections Immunol Today. 2000 Apr; 21(4):191. Borregaard N, Elsbach P, Ganz T, Garred P, Svejgaard A. PMID: 10740242.
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    299. Innate immunity: from plants to humans. Immunol Today. 2000 Feb; 21(2):68-70. Borregaard N, Elsbach P, Ganz T, Garred P, Svejgaard A. PMID: 10652463.
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    300. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol. 1999 Dec 15; 163(12):6718-24. O'Neil DA, Porter EM, Elewaut D, Anderson GM, Eckmann L, Ganz T, Kagnoff MF. PMID: 10586069.
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    301. Defensins and innate host defence of the gastrointestinal tract. Gut. 1999 Dec; 45(6):911-5. Bevins CL, Martin-Porter E, Ganz T. PMID: 10562592; PMCID: PMC1727760.
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    302. Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein. Pediatrics. 1999 Dec; 104(6):1327-33. Levy O, Martin S, Eichenwald E, Ganz T, Valore E, Carroll SF, Lee K, Goldmann D, Thorne GM. PMID: 10585984.
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    303. Defensins and host defense. Science. 1999 Oct 15; 286(5439):420-1. Ganz T. PMID: 10577203.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    304. Defensin promotes the binding of lipoprotein(a) to vascular matrix. Blood. 1999 Sep 15; 94(6):2007-19. Bdeir K, Cane W, Canziani G, Chaiken I, Weisel J, Koschinsky ML, Lawn RM, Bannerman PG, Sachais BS, Kuo A, Hancock MA, Tomaszewski J, Raghunath PN, Ganz T, Higazi AA, Cines DB. PMID: 10477730.
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    305. Oxygen-independent microbicidal mechanisms of phagocytes. Proc Assoc Am Physicians. 1999 Sep-Oct; 111(5):390-5. Ganz T. PMID: 10519158.
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    306. Antibiotic peptides from higher eukaryotes: biology and applications. Mol Med Today. 1999 Jul; 5(7):292-7. Ganz T, Lehrer RI. PMID: 10377520.
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    307. Innate antimicrobial activity of nasal secretions. Infect Immun. 1999 Jul; 67(7):3267-75. Cole AM, Dewan P, Ganz T. PMID: 10377100; PMCID: PMC116505.
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    308. A 450-kb contig of defensin genes on human chromosome 8p23. Gene. 1999 Jun 11; 233(1-2):205-11. Linzmeier R, Ho CH, Hoang BV, Ganz T. PMID: 10375637.
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    309. Eukaryotic antibiotic peptides: not only a membrane business. Drug Discov Today. 1999 Jun; 4(6):254-256. Rivas L, Ganz T. PMID: 10354539.
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    310. Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations. Infect Immun. 1999 Jun; 67(6):3121-7. Shi J, Zhang G, Wu H, Ross C, Blecha F, Ganz T. PMID: 10338529; PMCID: PMC96630.
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    311. Immunomagnetic recovery of human neutrophil defensins from the human gingival crevice. Oral Microbiol Immunol. 1999 Jun; 14(3):190-3. McKay MS, Olson E, Hesla MA, Panyutich A, Ganz T, Perkins S, Rossomando EF. PMID: 10495714.
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    312. Antimicrobial peptides in mammalian and insect host defence. Curr Opin Immunol. 1999 Feb; 11(1):23-7. Lehrer RI, Ganz T. PMID: 10047545.
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    313. Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14961-6. Singh PK, Jia HP, Wiles K, Hesselberth J, Liu L, Conway BA, Greenberg EP, Valore EV, Welsh MJ, Ganz T, Tack BF, McCray PB. PMID: 9843998; PMCID: PMC24558.
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    314. Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene. 1998 Nov 19; 222(2):237-44. Liu L, Wang L, Jia HP, Zhao C, Heng HH, Schutte BC, McCray PB, Ganz T. PMID: 9831658.
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    315. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 1998 Oct 02; 282(5386):121-5. Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melián A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL. PMID: 9756476.
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    316. Isolation of human intestinal defensins from ileal neobladder urine. FEBS Lett. 1998 Sep 04; 434(3):272-6. Porter EM, Poles MA, Lee JS, Naitoh J, Bevins CL, Ganz T. PMID: 9742937.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    317. The role of protegrins and other elastase-activated polypeptides in the bactericidal properties of porcine inflammatory fluids. Infect Immun. 1998 Aug; 66(8):3611-7. Shi J, Ganz T. PMID: 9673240; PMCID: PMC108393.
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    318. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest. 1998 Apr 15; 101(8):1633-42. Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB, Ganz T. PMID: 9541493; PMCID: PMC508744.
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    319. Molecular cloning and tissue expression of porcine beta-defensin-1. FEBS Lett. 1998 Mar 06; 424(1-2):37-40. Zhang G, Wu H, Shi J, Ganz T, Ross CR, Blecha F. PMID: 9537511.
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    320. Antimicrobial peptides of vertebrates. Curr Opin Immunol. 1998 Feb; 10(1):41-4. Ganz T, Lehrer RI. PMID: 9523109.
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    321. Antimicrobial peptides of phagocytes and epithelia. Semin Hematol. 1997 Oct; 34(4):343-54. Ganz T, Weiss J. PMID: 9347585.
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    322. The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. Genomics. 1997 Aug 01; 43(3):316-20. Liu L, Zhao C, Heng HH, Ganz T. PMID: 9268634.
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    323. Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells. Blood. 1997 Jun 15; 89(12):4290-8. Higazi AA, Lavi E, Bdeir K, Ulrich AM, Jamieson DG, Rader DJ, Usher DC, Kane W, Ganz T, Cines DB. PMID: 9192751.
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    324. Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect Immun. 1997 Jun; 65(6):2396-401. Porter EM, van Dam E, Valore EV, Ganz T. PMID: 9169780; PMCID: PMC175332.
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    325. Localization of human intestinal defensin 5 in Paneth cell granules. Infect Immun. 1997 Jun; 65(6):2389-95. Porter EM, Liu L, Oren A, Anton PA, Ganz T. PMID: 9169779; PMCID: PMC175331.
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    326. Immunohistochemical localization of defensin in human coronary vessels. Am J Pathol. 1997 Mar; 150(3):1009-20. Barnathan ES, Raghunath PN, Tomaszewski JE, Ganz T, Cines DB. PMID: 9060838; PMCID: PMC1857878.
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    327. Porcine polymorphonuclear leukocytes generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrins. Infect Immun. 1997 Mar; 65(3):978-85. Panyutich A, Shi J, Boutz PL, Zhao C, Ganz T. PMID: 9038306; PMCID: PMC175078.
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    328. Purification and characterization of defensins from cystic fibrosis sputum. Inflamm Res. 1997 Mar; 46(3):98-102. Soong LB, Ganz T, Ellison A, Caughey GH. PMID: 9098722.
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    329. Differential scanning microcalorimetry indicates that human defensin, HNP-2, interacts specifically with biomembrane mimetic systems. Biochemistry. 1997 Feb 11; 36(6):1525-31. Lohner K, Latal A, Lehrer RI, Ganz T. PMID: 9063901.
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    330. Laboratory production of antimicrobial peptides in native conformation. Methods Mol Biol. 1997; 78:115-31. Valore EV, Ganz T. PMID: 9276301.
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    331. Antimicrobial peptides of leukocytes. Curr Opin Hematol. 1997 Jan; 4(1):53-8. Ganz T, Lehrer RI. PMID: 9050380.
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    332. Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides. Ann N Y Acad Sci. 1996 Oct 25; 797:228-39. Lehrer RI, Ganz T. PMID: 8993365.
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    333. Defensin modulates tissue-type plasminogen activator and plasminogen binding to fibrin and endothelial cells. J Biol Chem. 1996 Jul 26; 271(30):17650-5. Higazi AA, Ganz T, Kariko K, Cines DB. PMID: 8663495.
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    334. Intramolecular inhibition of human defensin HNP-1 by its propiece. J Clin Invest. 1996 Apr 01; 97(7):1624-9. Valore EV, Martin E, Harwig SS, Ganz T. PMID: 8601627; PMCID: PMC507226.
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    335. Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39. FEBS Lett. 1995 Dec 04; 376(3):130-4. Zhao C, Ganz T, Lehrer RI. PMID: 7498526.
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    336. Defensins and other endogenous peptide antibiotics of vertebrates. J Leukoc Biol. 1995 Aug; 58(2):128-36. Martin E, Ganz T, Lehrer RI. PMID: 7643008.
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    337. The structure of porcine protegrin genes. FEBS Lett. 1995 Jul 17; 368(2):197-202. Zhao C, Ganz T, Lehrer RI. PMID: 7628604.
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    338. Defensins. Pharmacol Ther. 1995 May; 66(2):191-205. Ganz T, Lehrer RI. PMID: 7667395.
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    339. Murine 32D c13 cells--a transfectable model of phagocyte granule formation. J Immunol Methods. 1995 Apr 26; 181(2):253-8. Liu L, Oren A, Ganz T. PMID: 7745254.
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    340. Human neutrophil defensin and serpins form complexes and inactivate each other. Am J Respir Cell Mol Biol. 1995 Mar; 12(3):351-7. Panyutich AV, Hiemstra PS, van Wetering S, Ganz T. PMID: 7873202.
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    341. The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting. Blood. 1995 Feb 15; 85(4):1095-103. Liu L, Ganz T. PMID: 7849297.
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    342. Identification of defensin binding to C1 complement. FEBS Lett. 1994 Dec 19; 356(2-3):169-73. Panyutich AV, Szold O, Poon PH, Tseng Y, Ganz T. PMID: 7805831.
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    343. Defensins. Curr Opin Immunol. 1994 Aug; 6(4):584-9. Ganz T, Lehrer RI. PMID: 7946046.
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    344. Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin. Infect Immun. 1994 Jun; 62(6):2375-8. Couto MA, Liu L, Lehrer RI, Ganz T. PMID: 8188361; PMCID: PMC186521.
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    345. Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology. 1994 Feb 28; 87(1-3):131-49. Kagan BL, Ganz T, Lehrer RI. PMID: 7512758.
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    346. Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol. 1994; 236:160-72. Harwig SS, Ganz T, Lehrer RI. PMID: 7968608.
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    347. Biosynthesis of defensins and other antimicrobial peptides. Ciba Found Symp. 1994; 186:62-71; discussion 71-6. Ganz T. PMID: 7768158.
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    348. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. J Lab Clin Med. 1993 Aug; 122(2):202-7. Panyutich AV, Panyutich EA, Krapivin VA, Baturevich EA, Ganz T. PMID: 8340706.
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    349. Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines. Blood. 1993 Jul 15; 82(2):641-50. Ganz T, Liu L, Valore EV, Oren A. PMID: 8329717.
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    350. The structure of neutrophil defensin genes. FEBS Lett. 1993 Jul 12; 326(1-3):299-300. Linzmeier R, Michaelson D, Liu L, Ganz T. PMID: 8325384.
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    351. The structure of neutrophil defensin genes. FEBS Lett. 1993 Apr 26; 321(2-3):267-73. Linzmeier R, Michaelson D, Liu L, Ganz T. PMID: 8477861.
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    352. The effect of biotinylation on the antigenic specificity of anti-defensin monoclonal antibodies. J Immunol Methods. 1993 Feb 03; 158(2):237-42. Panyutich AV, Baturevich EA, Kolesnikova TS, Ganz T. PMID: 7679133.
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    353. Macrophage function. New Horiz. 1993 Feb; 1(1):23-7. Ganz T. PMID: 7922389.
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    354. Defensins reduce the barrier integrity of a cultured epithelial monolayer without cytotoxicity. Am J Respir Cell Mol Biol. 1993 Feb; 8(2):193-200. Nygaard SD, Ganz T, Peterson MW. PMID: 8427710.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    355. Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu Rev Immunol. 1993; 11:105-28. Lehrer RI, Lichtenstein AK, Ganz T. PMID: 8476558.
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    356. Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare. Infect Immun. 1992 Nov; 60(11):4720-5. Ogata K, Linzer BA, Zuberi RI, Ganz T, Lehrer RI, Catanzaro A. PMID: 1398982; PMCID: PMC258223.
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    357. Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity? J Leukoc Biol. 1992 Jun; 51(6):634-9. Michaelson D, Rayner J, Couto M, Ganz T. PMID: 1613398.
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    358. Posttranslational processing of defensins in immature human myeloid cells. Blood. 1992 Mar 15; 79(6):1538-44. Valore EV, Ganz T. PMID: 1339298.
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    359. Host defense in pulmonary alveoli. Annu Rev Physiol. 1992; 54:331-50. Sherman MP, Ganz T. PMID: 1562178.
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    360. Defensins: microbicidal and cytotoxic peptides of mammalian host defense cells. Med Microbiol Immunol. 1992; 181(2):99-105. Ganz T, Oren A, Lehrer RI. PMID: 1406461.
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    361. Defensins: endogenous antibiotic peptides from human leukocytes. Ciba Found Symp. 1992; 171:276-90; discussion 290-3. Lehrer RI, Ganz T. PMID: 1302183.
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    362. An enzyme immunoassay for human defensins. J Immunol Methods. 1991 Aug 09; 141(2):149-55. Panyutich AV, Voitenok NN, Lehrer RI, Ganz T. PMID: 1880422.
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    363. Activated alpha 2-macroglobulin is a principal defensin-binding protein. Am J Respir Cell Mol Biol. 1991 Aug; 5(2):101-6. Panyutich A, Ganz T. PMID: 1716445.
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    364. Contribution of rabbit leukocyte defensins to the host response in experimental syphilis. Infect Immun. 1991 Apr; 59(4):1368-77. Borenstein LA, Ganz T, Sell S, Lehrer RI, Miller JN. PMID: 2004817; PMCID: PMC257852.
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    365. Defensins: endogenous antibiotic peptides of animal cells. Cell. 1991 Jan 25; 64(2):229-30. Lehrer RI, Ganz T, Selsted ME. PMID: 1988144.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    366. Antimicrobial polypeptides of human neutrophils. Blood. 1990 Dec 01; 76(11):2169-81. Lehrer RI, Ganz T. PMID: 2257291.
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    367. Polymorphic expression of defensins in neutrophils from outbred rats. Infect Immun. 1990 Dec; 58(12):3899-902. Eisenhauer P, Harwig SS, Szklarek D, Ganz T, Lehrer RI. PMID: 2254017; PMCID: PMC313752.
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    368. Killing of oral, gram-negative, facultative bacteria by the rabbit defensin, NP-1. Oral Microbiol Immunol. 1990 Dec; 5(6):315-9. Miyasaki KT, Bodeau AL, Selsted ME, Ganz T, Lehrer RI. PMID: 2098709.
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    369. In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins. Infect Immun. 1990 Dec; 58(12):3934-40. Miyasaki KT, Bodeau AL, Ganz T, Selsted ME, Lehrer RI. PMID: 2254020; PMCID: PMC313758.
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    370. Purification and characterization of a major phosphatidylserine-binding phosphoprotein from human platelets. Biochem J. 1990 Aug 01; 269(3):729-34. Burgener R, Wolf M, Ganz T, Baggiolini M. PMID: 2390065; PMCID: PMC1131648.
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    371. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol. 1990 Aug; 86(2):202-10. Saxon A, Shanahan F, Landers C, Ganz T, Targan S. PMID: 2200820.
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    372. Direct cytotoxicity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells. Am Rev Respir Dis. 1990 Jan; 141(1):179-85. Okrent DG, Lichtenstein AK, Ganz T. PMID: 2297176.
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    373. Defensins. Eur J Haematol. 1990 Jan; 44(1):1-8. Ganz T, Selsted ME, Lehrer RI. PMID: 2407547.
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    374. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):210-4. Kagan BL, Selsted ME, Ganz T, Lehrer RI. PMID: 1688654; PMCID: PMC53231.
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    375. Monocyte-chemotactic activity of defensins from human neutrophils. J Clin Invest. 1989 Dec; 84(6):2017-20. Territo MC, Ganz T, Selsted ME, Lehrer R. PMID: 2592571; PMCID: PMC304087.
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    376. The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes. J Cell Biol. 1989 Dec; 109(6 Pt 1):2771-82. Joiner KA, Ganz T, Albert J, Rotrosen D. PMID: 2480351; PMCID: PMC2115971.
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    377. The utility of detecting of autoantibodies against neutrophil cytoplasmic components in Wegener's granulomatosis. Ann Allergy. 1989 Nov; 63(5):411-6. Chng HH, Ganz T, Saxon A. PMID: 2817531.
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    378. The structure of the rabbit macrophage defensin genes and their organ-specific expression. J Immunol. 1989 Aug 15; 143(4):1358-65. Ganz T, Rayner JR, Valore EV, Tumolo A, Talmadge K, Fuller F. PMID: 2745983.
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    379. Assignment of defensin gene(s) to human chromosome 8p23. Genomics. 1989 Aug; 5(2):240-4. Sparkes RS, Kronenberg M, Heinzmann C, Daher KA, Klisak I, Ganz T, Mohandas T. PMID: 2793180.
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    380. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest. 1989 Aug; 84(2):553-61. Lehrer RI, Barton A, Daher KA, Harwig SS, Ganz T, Selsted ME. PMID: 2668334; PMCID: PMC548915.
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    381. Purification and antimicrobial properties of three defensins from rat neutrophils. Infect Immun. 1989 Jul; 57(7):2021-7. Eisenhauer PB, Harwig SS, Szklarek D, Ganz T, Selsted ME, Lehrer RI. PMID: 2543629; PMCID: PMC313836.
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    382. Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein. J Immunol. 1989 Jun 15; 142(12):4428-34. Lehrer RI, Szklarek D, Barton A, Ganz T, Hamann KJ, Gleich GJ. PMID: 2656865.
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    383. Isolation and characterization of human defensin cDNA clones. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7327-31. Daher KA, Lehrer RI, Ganz T, Kronenberg M. PMID: 3174637; PMCID: PMC282179.
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    384. Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency. J Clin Invest. 1988 Aug; 82(2):552-6. Ganz T, Metcalf JA, Gallin JI, Boxer LA, Lehrer RI. PMID: 2841356; PMCID: PMC303547.
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    385. Neutrophils and host defense. Ann Intern Med. 1988 Jul 15; 109(2):127-42. Lehrer RI, Ganz T, Selsted ME, Babior BM, Curnutte JT. PMID: 3289431.
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    386. Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. J Clin Invest. 1988 Jun; 81(6):1829-35. Lehrer RI, Ganz T, Szklarek D, Selsted ME. PMID: 3290255; PMCID: PMC442632.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    387. Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins. Cell Immunol. 1988 Jun; 114(1):104-16. Lichtenstein AK, Ganz T, Selsted ME, Lehrer RI. PMID: 2836069.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    388. Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity. J Immunol. 1988 Apr 15; 140(8):2686-94. Lichtenstein AK, Ganz T, Nguyen TM, Selsted ME, Lehrer RI. PMID: 3162745.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    389. Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry. J Immunol Methods. 1988 Apr 06; 108(1-2):153-8. Lehrer RI, Barton A, Ganz T. PMID: 3127470.
      View in: PubMed   Mentions:
    390. Oxygen-independent bactericidal systems. Mechanisms and disorders. Hematol Oncol Clin North Am. 1988 Mar; 2(1):159-69. Lehrer RI, Ganz T, Selsted ME. PMID: 3279018.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    391. Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils. Biochem Pharmacol. 1988 Mar 01; 37(5):951-6. Charp PA, Rice WG, Raynor RL, Reimund E, Kinkade JM, Ganz T, Selsted ME, Lehrer RI, Kuo JF. PMID: 3345204.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    392. Defensin-rich dense granules of human neutrophils. Blood. 1987 Sep; 70(3):757-65. Rice WG, Ganz T, Kinkade JM, Selsted ME, Lehrer RI, Parmley RT. PMID: 3040155.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    393. Defensins mediate the microbicidal activity of human neutrophil granule extract against Acinetobacter calcoaceticus. Infect Immun. 1987 Jun; 55(6):1365-8. Greenwald GI, Ganz T. PMID: 3570467; PMCID: PMC260521.
      View in: PubMed   Mentions:
    394. Preventive therapy of emphysema: lessons from the elastase model. Am Rev Respir Dis. 1987 Apr; 135(4):984. Ganz T. PMID: 3565949.
      View in: PubMed   Mentions:
    395. Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes. Infect Immun. 1987 Mar; 55(3):568-71. Ganz T. PMID: 3643886; PMCID: PMC260375.
      View in: PubMed   Mentions:
    396. In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood. 1986 Dec; 68(6):1407-10. Lichtenstein A, Ganz T, Selsted ME, Lehrer RI. PMID: 3779104.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    397. In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages. J Infect Dis. 1986 Sep; 154(3):483-9. Levitz SM, Selsted ME, Ganz T, Lehrer RI, Diamond RD. PMID: 3525696.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    398. Antimicrobial activity of phagocyte granule proteins. Semin Respir Infect. 1986 Jun; 1(2):107-17. Ganz T, Selsted ME, Lehrer RI. PMID: 3317602.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    399. Synergistic activity of rabbit granulocyte peptides against Candida albicans. Infect Immun. 1986 Jun; 52(3):902-4. Lehrer RI, Szklarek D, Ganz T, Selsted ME. PMID: 3519465; PMCID: PMC260946.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    400. Primary structures of three human neutrophil defensins. J Clin Invest. 1985 Oct; 76(4):1436-9. Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI. PMID: 4056036; PMCID: PMC424095.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimalsCells
    401. Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest. 1985 Oct; 76(4):1427-35. Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI. PMID: 2997278; PMCID: PMC424093.
      View in: PubMed   Mentions: 353     Fields:    Translation:HumansAnimalsCells
    402. Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2. Am Rev Respir Dis. 1985 Oct; 132(4):901-4. Ganz T, Sherman MP, Selsted ME, Lehrer RI. PMID: 4051325.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    403. Activity of rabbit leukocyte peptides against Candida albicans. Infect Immun. 1985 Jul; 49(1):202-6. Selsted ME, Szklarek D, Ganz T, Lehrer RI. PMID: 3891624; PMCID: PMC262079.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    404. Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity. Infect Immun. 1985 Jul; 49(1):207-11. Lehrer RI, Szklarek D, Ganz T, Selsted ME. PMID: 3891625; PMCID: PMC262080.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    405. Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes. J Virol. 1985 May; 54(2):467-72. Lehrer RI, Daher K, Ganz T, Selsted ME. PMID: 2985808; PMCID: PMC254818.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    406. Molecular cloning of the rat metallothionein 1 (MT-1) mRNA sequence. DNA. 1983; 2(1):15-22. Andersen RD, Birren BW, Ganz T, Piletz JE, Herschman HR. PMID: 6687866.
      View in: PubMed   Mentions:
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