Yazhen Zhu

Title(s)	Assistant Professor-in-residence, Pathology and Laboratory Medicine
School	Medicine
ORCID	0000-0002-2130-8085
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Other Positions


Title(s)	Assistant Professor-in-residence, Molecular and Medical Pharmacology

Research

Research Activities and Funding

Click Chemistry-Mediated Surface Protein Assay for Quantifying Subpopulations of Hepatocellular Carcinoma-associated Extracellular Vesicles
NIH/NCI R01CA277530Jul 1, 2023 - Jun 30, 2028
Role: Principal Investigator

Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular Carcinoma
NIH R01CA255727Jan 18, 2021 - Dec 31, 2025
Role: Principal Investigator

Biomimetic NanoVilli Chips for Extracellular Vesicles in Hepatocellular Carcinoma
NIH R21CA240887Apr 1, 2020 - Mar 31, 2022
Role: Principal Investigator

Click Chemistry-Mediated Microfluidic Sorting for HCC CTCs
NIH R21CA235340Apr 2, 2019 - Mar 31, 2022
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Placenta accreta spectrum disorder at single-cell resolution: a loss of boundary limits in the decidua and endothelium. Am J Obstet Gynecol. 2024 Apr; 230(4):443.e1-443.e18. Afshar Y, Yin O, Jeong A, Martinez G, Kim J, Ma F, Jang C, Tabatabaei S, You S, Tseng HR, Zhu Y, Krakow D. PMID: 38296740.

View in: PubMed Mentions: Fields:
Gyn Gynecology Obs Obstetrics
Exosomes from Von Hippel-Lindau-Null Cancer Cells Promote Metastasis in Renal Cell Carcinoma. Int J Mol Sci. 2023 Dec 09; 24(24). Flora K, Ishihara M, Zhang Z, Bowen ES, Wu A, Ayoub T, Huang J, Cano-Ruiz C, Jackson M, Reghu K, Ayoub Y, Zhu Y, Tseng HR, Zhou ZH, Hu J, Wu L. PMID: 38139136; PMCID: PMC10743428.

View in: PubMed Mentions: Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Humans Cells
Hierarchical integration of DNA nanostructures and NanoGold onto a microchip facilitates covalent chemistry-mediated purification of circulating tumor cells in head and neck squamous cell carcinoma. Nano Today. 2023 Apr; 49. Sun N, Zhang C, Wang J, Yue X, Kim HY, Zhang RY, Liu H, Widjaja J, Tang H, Zhang TX, Ye J, Qian A, Liu C, Wu A, Wang K, Johanis M, Yang P, Liu H, Meng M, Liang L, Pei R, Chai-Ho W, Zhu Y, Tseng HR. PMID: 38037608; PMCID: PMC10688595.

View in: PubMed Mentions:
HCC EV ECG score: An extracellular vesicle-based protein assay for detection of early-stage hepatocellular carcinoma. Hepatology. 2023 03 01; 77(3):774-788. Sun N, Zhang C, Lee YT, Tran BV, Wang J, Kim H, Lee J, Zhang RY, Wang JJ, Hu J, Zhang Z, Alsudaney MS, Hou KC, Tang H, Zhang TX, Liang IY, Zhou Z, Chen M, Yeh AH, Li W, Zhou XJ, Chang HR, Han SB, Sadeghi S, Finn RS, Saab S, Busuttil RW, Noureddin M, Ayoub WS, Kuo A, Sundaram V, Al-Ghaieb B, Palomique J, Kosari K, Kim IK, Todo T, Nissen NN, Tomasi ML, You S, Posadas EM, Wu JX, Wadehra M, Sim MS, Li Y, Wang HL, French SW, Lu SC, Wu L, Pei R, Liang L, Yang JD, Agopian VG, Tseng HR, Zhu Y. PMID: 35908246; PMCID: PMC9887095.

View in: PubMed Mentions: 11 Fields:
Gas Gastroenterology
Translation:Humans Cells
Reply. Hepatology. 2023 Mar 01; 77(3):E53-E54. Lee YT, Zhu Y, Yang JD, Agopian VG, Tseng HR. PMID: 36056798.

View in: PubMed Mentions: Fields:
Gas Gastroenterology
Cost-effective methylome sequencing of cell-free DNA for accurately detecting and locating cancer. Nat Commun. 2022 09 29; 13(1):5566. Stackpole ML, Zeng W, Li S, Liu CC, Zhou Y, He S, Yeh A, Wang Z, Sun F, Li Q, Yuan Z, Yildirim A, Chen PJ, Winograd P, Tran B, Lee YT, Li PS, Noor Z, Yokomizo M, Ahuja P, Zhu Y, Tseng HR, Tomlinson JS, Garon E, French S, Magyar CE, Dry S, Lajonchere C, Geschwind D, Choi G, Saab S, Alber F, Wong WH, Dubinett SM, Aberle DR, Agopian V, Han SB, Ni X, Li W, Zhou XJ. PMID: 36175411; PMCID: PMC9522828.

View in: PubMed Mentions: 11 Fields:
Bio Biology Sci Science
Translation:Humans
Early detection of primary liver cancer using plasma cell-free DNA fragmentomics: Do all the pieces come together? Hepatology. 2022 08; 76(2):289-291. Agopian VG, Yang JD, Zhu Y, You S, Tseng HR. PMID: 35124841.

View in: PubMed Mentions: Fields:
Gas Gastroenterology
Translation:Humans
Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations. Adv Sci (Weinh). 2022 05; 9(14):e2105853. Sun N, Tran BV, Peng Z, Wang J, Zhang C, Yang P, Zhang TX, Widjaja J, Zhang RY, Xia W, Keir A, She JW, Yu HH, Shyue JJ, Zhu H, Agopian VG, Pei R, Tomlinson JS, Toretsky JA, Jonas SJ, Federman N, Lu S, Tseng HR, Zhu Y. PMID: 35486030; PMCID: PMC9108594.

View in: PubMed Mentions: 8 Fields:
Bio Biomedical Engineering
Translation:Humans Cells
Discovery and characterization of circulating tumor cell clusters in neuroendocrine tumor patients using nanosubstrate-embedded microchips. Biosens Bioelectron. 2022 Mar 01; 199:113854. Sun N, Yang Y, Miao H, Redublo P, Liu H, Liu W, Huang YW, Teng PC, Zhang C, Zhang RY, Smalley M, Yang P, Chou SJ, Huai K, Zhang Z, Lee YT, Wang JJ, Wang J, Liang IY, Zhang TX, Zhang D, Liang L, Weiss PS, Posadas EM, Donahue T, Hecht JR, Allen-Auerbach MS, Bergsland EK, Hope TA, Pei R, Zhu Y, Tseng HR, Heaney AP. PMID: 34896918; PMCID: PMC8900541.

View in: PubMed Mentions: 6 Fields:
Bio Biotechnology
Translation:Humans Cells
Circulating Tumor Cell-Based Messenger RNA Scoring System for Prognostication of Hepatocellular Carcinoma: Translating Tissue-Based Messenger RNA Profiling Into a Noninvasive Setting. Liver Transpl. 2022 02; 28(2):200-214. Lee YT, Sun N, Kim M, Wang JJ, Tran BV, Zhang RY, Qi D, Zhang C, Chen PJ, Sadeghi S, Finn RS, Saab S, Han SB, Busuttil RW, Pei R, Zhu Y, Tseng HR, You S, Yang JD, Agopian VG. PMID: 34664394; PMCID: PMC8820407.

View in: PubMed Mentions: 5 Fields:
Gas Gastroenterology Tra Transplantation
Translation:Humans Cells
Diagnostic Criteria and LI-RADS for Hepatocellular Carcinoma. Clin Liver Dis (Hoboken). 2021 Jun; 17(6):409-413. Lee YT, Wang JJ, Zhu Y, Agopian VG, Tseng HR, Yang JD. PMID: 34386205; PMCID: PMC8340355.

View in: PubMed Mentions: 13
Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders. Nat Commun. 2021 08 03; 12(1):4408. Afshar Y, Dong J, Zhao P, Li L, Wang S, Zhang RY, Zhang C, Yin O, Han CS, Einerson BD, Gonzalez TL, Zhang H, Zhou A, Yang Z, Chou SJ, Sun N, Cheng J, Zhu H, Wang J, Zhang TX, Lee YT, Wang JJ, Teng PC, Yang P, Qi D, Zhao M, Sim MS, Zhe R, Goldstein JD, Williams J, Wang X, Zhang Q, Platt LD, Zou C, Pisarska MD, Tseng HR, Zhu Y. PMID: 34344888; PMCID: PMC8333096.

View in: PubMed Mentions: 12 Fields:
Bio Biology Sci Science
Translation:Humans Cells
The Role of Extracellular Vesicles in Disease Progression and Detection of Hepatocellular Carcinoma. Cancers (Basel). 2021 Jun 20; 13(12). Lee YT, Tran BV, Wang JJ, Liang IY, You S, Zhu Y, Agopian VG, Tseng HR, Yang JD. PMID: 34203086; PMCID: PMC8233859.

View in: PubMed Mentions: 12
Covalent Chemistry-Mediated Multimarker Purification of Circulating Tumor Cells Enables Noninvasive Detection of Molecular Signatures of Hepatocellular Carcinoma. Adv Mater Technol. 2021 May; 6(5). Sun N, Lee YT, Kim M, Wang JJ, Zhang C, Teng PC, Qi D, Zhang RY, Tran BV, Lee YT, Ye J, Palomique J, Nissen NN, Han SB, Sadeghi S, Finn RS, Saab S, Busuttil RW, Posadas EM, Liang L, Pei R, Yang JD, You S, Agopian VG, Tseng HR, Zhu Y. PMID: 34212072; PMCID: PMC8240468.

View in: PubMed Mentions: 2
Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies. Adv Funct Mater. 2020 Dec 01; 30(49). Dong J, Zhang RY, Sun N, Hu J, Smalley MD, Zhou A, Yue H, Rothermich W, Chen M, Chen J, Ye J, Teng PC, Qi D, Toretsky JA, Tomlinson JS, Li M, Weiss PS, Jonas SJ, Federman N, Wu L, Zhao M, Tseng HR, Zhu Y. PMID: 34220409; PMCID: PMC8248519.

View in: PubMed Mentions: 12
Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring. Nat Commun. 2020 09 07; 11(1):4489. Sun N, Lee YT, Zhang RY, Kao R, Teng PC, Yang Y, Yang P, Wang JJ, Smalley M, Chen PJ, Kim M, Chou SJ, Bao L, Wang J, Zhang X, Qi D, Palomique J, Nissen N, Han SB, Sadeghi S, Finn RS, Saab S, Busuttil RW, Markovic D, Elashoff D, Yu HH, Li H, Heaney AP, Posadas E, You S, Yang JD, Pei R, Agopian VG, Tseng HR, Zhu Y. PMID: 32895384; PMCID: PMC7477161.

View in: PubMed Mentions: 68 Fields:
Bio Biology Sci Science
Translation:Humans Cells
Hepatocellular Carcinoma-Circulating Tumor Cells Expressing PD-L1 Are Prognostic and Potentially Associated With Response to Checkpoint Inhibitors. Hepatol Commun. 2020 Oct; 4(10):1527-1540. Winograd P, Hou S, Court CM, Lee YT, Chen PJ, Zhu Y, Sadeghi S, Finn RS, Teng PC, Wang JJ, Zhang Z, Liu H, Busuttil RW, Tomlinson JS, Tseng HR, Agopian VG. PMID: 33024921; PMCID: PMC7527695.

View in: PubMed Mentions: 46 Fields:
Gas Gastroenterology
A circulating tumor cell-based digital assay for the detection of EGFR T790M mutation in advanced non-small cell lung cancer. J Mater Chem B. 2020 07 08; 8(26):5636-5644. Wang J, Sun N, Lee YT, Ni Y, Koochekpour R, Zhu Y, Tseng HR, Wang S, Jiang L, Zhu H. PMID: 32525199; PMCID: PMC8136811.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry Bio Biotechnology Nan Nanotechnology
Translation:Humans Cells
Somatic copy number profiling from hepatocellular carcinoma circulating tumor cells. NPJ Precis Oncol. 2020; 4:16. Court CM, Hou S, Liu L, Winograd P, DiPardo BJ, Liu SX, Chen PJ, Zhu Y, Smalley M, Zhang R, Sadeghi S, Finn RS, Kaldas FM, Busuttil RW, Zhou XJ, Tseng HR, Tomlinson JS, Graeber TG, Agopian VG. PMID: 32637655; PMCID: PMC7331695.

View in: PubMed Mentions: 8
Nanostructured Substrates for Detection and Characterization of Circulating Rare Cells: From Materials Research to Clinical Applications. Adv Mater. 2020 Jan; 32(1):e1903663. Dong J, Chen JF, Smalley M, Zhao M, Ke Z, Zhu Y, Tseng HR. PMID: 31566837; PMCID: PMC6946854.

View in: PubMed Mentions: 26 Fields:
Bio Biophysics Che Chemistry
Translation:Humans Cells
Covalent chemistry on nanostructured substrates enables noninvasive quantification of gene rearrangements in circulating tumor cells. Sci Adv. 2019 07; 5(7):eaav9186. Dong J, Jan YJ, Cheng J, Zhang RY, Meng M, Smalley M, Chen PJ, Tang X, Tseng P, Bao L, Huang TY, Zhou D, Liu Y, Chai X, Zhang H, Zhou A, Agopian VG, Posadas EM, Shyue JJ, Jonas SJ, Weiss PS, Li M, Zheng G, Yu HH, Zhao M, Tseng HR, Zhu Y. PMID: 31392269; PMCID: PMC6669017.

View in: PubMed Mentions: 12 Fields:
Sci Science
Translation:Humans Cells
Noninvasive Prenatal Diagnostics: Recent Developments Using Circulating Fetal Nucleated Cells. Curr Obstet Gynecol Rep. 2019 Mar; 8(1):1-8. Pin-Jung C, Pai-Chi T, Zhu Y, Jen Jan Y, Smalley M, Afshar Y, Li-Ching C, Pisarska MD, Hsian-Rong T. PMID: 31565541; PMCID: PMC6764767.

View in: PubMed Mentions: 4
A novel multimarker assay for the phenotypic profiling of circulating tumor cells in hepatocellular carcinoma. Liver Transpl. 2018 07; 24(7):946-960. Court CM, Hou S, Winograd P, Segel NH, Li QW, Zhu Y, Sadeghi S, Finn RS, Ganapathy E, Song M, French SW, Naini BV, Sho S, Kaldas FM, Busuttil RW, Tomlinson JS, Tseng HR, Agopian VG. PMID: 29624843; PMCID: PMC6097911.

View in: PubMed Mentions: 43 Fields:
Gas Gastroenterology Tra Transplantation
Translation:Humans Cells
NanoVelcro rare-cell assays for detection and characterization of circulating tumor cells. Adv Drug Deliv Rev. 2018 02 01; 125:78-93. Jan YJ, Chen JF, Zhu Y, Lu YT, Chen SH, Chung H, Smalley M, Huang YW, Dong J, Chen LC, Yu HH, Tomlinson JS, Hou S, Agopian VG, Posadas EM, Tseng HR. PMID: 29551650; PMCID: PMC5993593.

View in: PubMed Mentions: 41 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans Cells
Imprinted NanoVelcro Microchips for Isolation and Characterization of Circulating Fetal Trophoblasts: Toward Noninvasive Prenatal Diagnostics. ACS Nano. 2017 08 22; 11(8):8167-8177. Hou S, Chen JF, Song M, Zhu Y, Jan YJ, Chen SH, Weng TH, Ling DA, Chen SF, Ro T, Liang AJ, Lee T, Jin H, Li M, Liu L, Hsiao YS, Chen P, Yu HH, Tsai MS, Pisarska MD, Chen A, Chen LC, Tseng HR. PMID: 28721719; PMCID: PMC5614709.

View in: PubMed Mentions: 29 Fields:
Nan Nanotechnology
Translation:Humans Cells
Cross-Linked Fluorescent Supramolecular Nanoparticles as Finite Tattoo Pigments with Controllable Intradermal Retention Times. ACS Nano. 2017 01 24; 11(1):153-162. Choi JS, Zhu Y, Li H, Peyda P, Nguyen TT, Shen MY, Yang YM, Zhu J, Liu M, Lee MM, Sun SS, Yang Y, Yu HH, Chen K, Chuang GS, Tseng HR. PMID: 27997116; PMCID: PMC5577983.

View in: PubMed Mentions: 4 Fields:
Nan Nanotechnology