Loading...

Zhai, Yuan

Title(s)Professor-in-Residence, Surgery
SchoolLiver and Pancreas
Phone59426
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Glycogen Synthase Kinase 3 beta in liver ischemia reperfusion injury
    NIH/NIDDK R01DK119338May 1, 2020 - Feb 29, 2024
    Role: Principal Investigator
    Kupffer Cell Necroptosis and Homeostatic Function in Liver Immune Responses against Ischemia Reperfusion Injury
    NIH/NIAID R21AI126516Jun 15, 2016 - May 31, 2018
    Role: Principal Investigator
    CXCL10/CXCR3 Signaling Regulates TLR4-Mediated Liver Inflamation and Injury
    NIH/NIDDK R01DK083408Mar 25, 2010 - Feb 28, 2015
    Role: Principal Investigator
    NRF2 - SIRT1 SIGNALING AXIS IN LIVER TRANSPLANT REJUVENATION
    NIH/NIDDK R01DK062357Jul 1, 2002 - Jan 31, 2014
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Jin D, Lu T, Ni M, Wang H, Zhang J, Zhong C, Shen C, Hao J, Busuttil RW, Kupiec-Weglinski JW, Zhang J, Xu N, Zhai Y. Farnesoid X Receptor Activation Protects Liver From Ischemia/Reperfusion Injury by Up-Regulating Small Heterodimer Partner in Kupffer Cells. Hepatol Commun. 2020 Apr; 4(4):540-554. PMID: 32258949.
      View in: PubMed
    2. Zhai Y, Kupiec-Weglinski JW. Peacekeepers are cross-dressed in the liver land. Hepatology. 2018 04; 67(4):1221-1223. PMID: 29194675.
      View in: PubMed
    3. Zhou H, Wang H, Ni M, Yue S, Xia Y, Busuttil RW, Kupiec-Weglinski JW, Lu L, Wang X, Zhai Y. Glycogen synthase kinase 3ß promotes liver innate immune activation by restraining AMP-activated protein kinase activation. J Hepatol. 2018 07; 69(1):99-109. PMID: 29452207.
      View in: PubMed
    4. Yue S, Zhou H, Wang X, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury. J Immunol. 2017 05 01; 198(9):3588-3595. PMID: 28289160.
      View in: PubMed
    5. Lu L, Zhou H, Ni M, Wang X, Busuttil R, Kupiec-Weglinski J, Zhai Y. Innate Immune Regulations and Liver Ischemia-Reperfusion Injury. Transplantation. 2016 Dec; 100(12):2601-2610. PMID: 27861288.
      View in: PubMed
    6. Zhou H, Zhu J, Yue S, Lu L, Busuttil RW, Kupiec-Weglinski JW, Wang X, Zhai Y. The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury. Transplantation. 2016 Feb; 100(2):365-72. PMID: 26683513.
      View in: PubMed
    7. Yue S, Zhou HM, Zhu JJ, Rao JH, Busuttil RW, Kupiec-Weglinski JW, Lu L, Zhai Y. Hyperglycemia and liver ischemia reperfusion injury: a role for the advanced glycation endproduct and its receptor pathway. Am J Transplant. 2015 Nov; 15(11):2877-87. PMID: 26112980.
      View in: PubMed
    8. Zhu J, Lu T, Yue S, Shen X, Gao F, Busuttil RW, Kupiec-Weglinski JW, Xia Q, Zhai Y. Rapamycin protection of livers from ischemia and reperfusion injury is dependent on both autophagy induction and mammalian target of rapamycin complex 2-Akt activation. Transplantation. 2015 Jan; 99(1):48-55. PMID: 25340604.
      View in: PubMed
    9. Rao J, Qian X, Li G, Pan X, Zhang C, Zhang F, Zhai Y, Wang X, Lu L. ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injury. Am J Transplant. 2015 Jan; 15(1):76-87. PMID: 25359217.
      View in: PubMed
    10. Huang J, Yue S, Ke B, Zhu J, Shen XD, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network. Transplantation. 2014 Oct 15; 98(7):721-8. PMID: 25171655.
      View in: PubMed
    11. Huang J, Shen XD, Yue S, Zhu J, Gao F, Zhai Y, Busuttil RW, Ke B, Kupiec-Weglinski JW. Adoptive transfer of heme oxygenase-1 (HO-1)-modified macrophages rescues the nuclear factor erythroid 2-related factor (Nrf2) antiinflammatory phenotype in liver ischemia/reperfusion injury. Mol Med. 2014 Oct 14; 20:448-55. PMID: 25014792.
      View in: PubMed
    12. Rao J, Yue S, Fu Y, Zhu J, Wang X, Busuttil RW, Kupiec-Weglinski JW, Lu L, Zhai Y. ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury. Am J Transplant. 2014 Jul; 14(7):1552-61. PMID: 24903305.
      View in: PubMed
    13. Yue S, Rao J, Zhu J, Busuttil RW, Kupiec-Weglinski JW, Lu L, Wang X, Zhai Y. Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation. J Immunol. 2014 Jun 01; 192(11):5343-5353. PMID: 24771857.
      View in: PubMed
    14. Rao J, Lu L, Zhai Y. T cells in organ ischemia reperfusion injury. Curr Opin Organ Transplant. 2014 Apr; 19(2):115-20. PMID: 24576906.
      View in: PubMed
    15. Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. J Hepatol. 2013 Dec; 59(6):1200-7. PMID: 23867319.
      View in: PubMed
    16. Zhai Y, Petrowsky H, Hong JC, Busuttil RW, Kupiec-Weglinski JW. Ischaemia-reperfusion injury in liver transplantation--from bench to bedside. Nat Rev Gastroenterol Hepatol. 2013 Feb; 10(2):79-89. PMID: 23229329.
      View in: PubMed
    17. Liu J, Ren F, Cheng Q, Bai L, Shen X, Gao F, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury. Transplantation. 2012 Aug 15; 94(3):211-7. PMID: 22790388.
      View in: PubMed
    18. Shen XD, Ke B, Ji H, Gao F, Freitas MC, Chang WW, Lee C, Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Disruption of Type-I IFN pathway ameliorates preservation damage in mouse orthotopic liver transplantation via HO-1 dependent mechanism. Am J Transplant. 2012 Jul; 12(7):1730-9. PMID: 22429450.
      View in: PubMed
    19. Ren F, Duan Z, Cheng Q, Shen X, Gao F, Bai L, Liu J, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism. Hepatology. 2011 Aug; 54(2):687-96. PMID: 21567437.
      View in: PubMed
    20. Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation. Am J Transplant. 2011 Aug; 11(8):1563-9. PMID: 21668640.
      View in: PubMed
    21. Ji H, Shen XD, Gao F, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. Alloreactive CD8 T-cell primed/memory responses and accelerated graft rejection in B-cell-deficient sensitized mice. Transplantation. 2011 May 27; 91(10):1075-81. PMID: 21427633.
      View in: PubMed
    22. Shen XD, Ke B, Uchida Y, Ji H, Gao F, Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury. Liver Transpl. 2011 Feb; 17(2):201-10. PMID: 21280193.
      View in: PubMed
    23. Ji H, Shen X, Gao F, Ke B, Freitas MC, Uchida Y, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury. Hepatology. 2010 Oct; 52(4):1380-9. PMID: 20815020.
      View in: PubMed
    24. Shen X, Reng F, Gao F, Uchida Y, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. Alloimmune activation enhances innate tissue inflammation/injury in a mouse model of liver ischemia/reperfusion injury. Am J Transplant. 2010 Aug; 10(8):1729-37. PMID: 20659085.
      View in: PubMed
    25. Ke B, Shen XD, Gao F, Ji H, Qiao B, Zhai Y, Farmer DG, Busuttil RW, Kupiec-Weglinski JW. Adoptive transfer of ex vivo HO-1 modified bone marrow-derived macrophages prevents liver ischemia and reperfusion injury. Mol Ther. 2010 May; 18(5):1019-25. PMID: 20029397.
      View in: PubMed
    26. Shen X, Wang Y, Gao F, Ren F, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury. Hepatology. 2009 Nov; 50(5):1537-46. PMID: 19670423.
      View in: PubMed
    27. Liu D, Shen XD, Zhai Y, Lam W, Liao J, Busuttil RW, Ghobrial RM. Intragraft selection of the T cell receptor repertoire by class I MHC sequences in tolerant recipients. PLoS One. 2009 Jun 29; 4(6):e6076. PMID: 19562081.
      View in: PubMed
    28. Wu Z, Wang Y, Gao F, Shen X, Zhai Y, Kupiec-Weglinski JW. Critical role of CD4 help in CD154 blockade-resistant memory CD8 T cell activation and allograft rejection in sensitized recipients. J Immunol. 2008 Jul 15; 181(2):1096-102. PMID: 18606661.
      View in: PubMed
    29. Meng L, Wu Z, Wang Y, Lassman C, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. Differential impact of CD154 costimulation blockade on alloreactive effector and regulatory T cells in murine renal transplant recipients. Transplantation. 2008 May 15; 85(9):1332-8. PMID: 18475192.
      View in: PubMed
    30. Zhai Y, Qiao B, Shen XD, Gao F, Busuttil RW, Cheng G, Platt JL, Volk HD, Kupiec-Weglinski JW. Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury. Transplantation. 2008 Apr 15; 85(7):1016-22. PMID: 18408583.
      View in: PubMed
    31. Zhai Y, Qiao B, Gao F, Shen X, Vardanian A, Busuttil RW, Kupiec-Weglinski JW. Type I, but not type II, interferon is critical in liver injury induced after ischemia and reperfusion. Hepatology. 2008 Jan; 47(1):199-206. PMID: 17935177.
      View in: PubMed
    32. Zhai Y, Shen XD, Gao F, Zhao A, Freitas MC, Lassman C, Luster AD, Busuttil RW, Kupiec-Weglinski JW. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Hepatology. 2008 Jan; 47(1):207-14. PMID: 18041715.
      View in: PubMed
    33. Zhai Y, Wang Y, Wu Z, Kupiec-Weglinski JW. Defective alloreactive CD8 T cell function and memory response in allograft recipients in the absence of CD4 help. J Immunol. 2007 Oct 01; 179(7):4529-34. PMID: 17878349.
      View in: PubMed
    34. Shen XD, Ke B, Zhai Y, Gao F, Tsuchihashi S, Lassman CR, Busuttil RW, Kupiec-Weglinski JW. Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model. Liver Transpl. 2007 Oct; 13(10):1435-43. PMID: 17902130.
      View in: PubMed
    35. Shen XD, Ke B, Zhai Y, Tsuchihashi SI, Gao F, Duarte S, Coito A, Busuttil RW, Allison AC, Kupiec-Weglinski JW. Diannexin, a novel annexin V homodimer, protects rat liver transplants against cold ischemia-reperfusion injury. Am J Transplant. 2007 Nov; 7(11):2463-71. PMID: 17868064.
      View in: PubMed
    36. Tsuchihashi S, Zhai Y, Bo Q, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 mediated cytoprotection against liver ischemia and reperfusion injury: inhibition of type-1 interferon signaling. Transplantation. 2007 Jun 27; 83(12):1628-34. PMID: 17589347.
      View in: PubMed
    37. Tsuchihashi S, Livhits M, Zhai Y, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. Basal rather than induced heme oxygenase-1 levels are crucial in the antioxidant cytoprotection. J Immunol. 2006 Oct 01; 177(7):4749-57. PMID: 16982915.
      View in: PubMed
    38. Tsuchihashi S, Kaldas F, Chida N, Sudo Y, Tamura K, Zhai Y, Qiao B, Busuttil RW, Kupiec-Weglinski JW. FK330, a novel inducible nitric oxide synthase inhibitor, prevents ischemia and reperfusion injury in rat liver transplantation. Am J Transplant. 2006 Sep; 6(9):2013-22. PMID: 16796718.
      View in: PubMed
    39. Zhai Y, Meng L, Gao F, Wang Y, Busuttil RW, Kupiec-Weglinski JW. CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent. J Immunol. 2006 May 15; 176(10):5988-94. PMID: 16670307.
      View in: PubMed
    40. Zhai Y, Shen XD, Hancock WW, Gao F, Qiao B, Lassman C, Belperio JA, Strieter RM, Busuttil RW, Kupiec-Weglinski JW. CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury. J Immunol. 2006 May 15; 176(10):6313-22. PMID: 16670343.
      View in: PubMed
    41. Shen XD, Gao F, Ke B, Zhai Y, Lassman CR, Tsuchihashi S, Farmer DG, Busuttil RW, Kupiec-Weglinski JW. Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation. Liver Transpl. 2005 Oct; 11(10):1273-81. PMID: 16184555.
      View in: PubMed
    42. Shen XD, Ke B, Zhai Y, Gao F, Busuttil RW, Cheng G, Kupiec-Weglinski JW. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant. 2005 Aug; 5(8):1793-800. PMID: 15996225.
      View in: PubMed
    43. Tsuchihashi S, Zhai Y, Fondevila C, Busuttil RW, Kupiec-Weglinski JW. HO-1 upregulation suppresses type 1 IFN pathway in hepatic ischemia/reperfusion injury. Transplant Proc. 2005 May; 37(4):1677-8. PMID: 15919427.
      View in: PubMed
    44. Zhai Y, Shen XD, O'Connell R, Gao F, Lassman C, Busuttil RW, Cheng G, Kupiec-Weglinski JW. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol. 2004 Dec 15; 173(12):7115-9. PMID: 15585830.
      View in: PubMed
    45. Araujo JA, Meng L, Tward AD, Hancock WW, Zhai Y, Lee A, Ishikawa K, Iyer S, Buelow R, Busuttil RW, Shih DM, Lusis AJ, Kupiec-Weglinski JW. Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol. 2003 Aug 01; 171(3):1572-80. PMID: 12874251.
      View in: PubMed
    46. Zhai Y, Meng L, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive. J Immunol. 2003 Mar 15; 170(6):3024-8. PMID: 12626556.
      View in: PubMed
    47. Zhai Y, Kupiec-Weglinski JW. T-cell receptor beta-chain usage in directly activated alloreactive CD4+ T cells: unrestricted Vbeta gene usage with CDR3 size limitations. Transplantation. 2003 Feb 27; 75(4):514-21. PMID: 12605120.
      View in: PubMed
    48. Shen XD, Ke B, Zhai Y, Gao F, Anselmo D, Lassman CR, Busuttil RW, Kupiec-Weglinski JW. Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection. Hepatology. 2003 Feb; 37(2):296-303. PMID: 12540779.
      View in: PubMed
    49. Zhai Y, Meng L, Gao F, Busuttil RW, Kupiec-Weglinski JW. Allograft rejection by primed/memory CD8+ T cells is CD154 blockade resistant: therapeutic implications for sensitized transplant recipients. J Immunol. 2002 Oct 15; 169(8):4667-73. PMID: 12370407.
      View in: PubMed
    50. Ke B, Shen XD, Zhai Y, Gao F, Busuttil RW, Volk HD, Kupiec-Weglinski JW. Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Hum Gene Ther. 2002 Oct 10; 13(15):1845-57. PMID: 12396617.
      View in: PubMed
    51. Zhai Y, Shen XD, Gao F, Coito AJ, Wasowska BA, Salama A, Schmitt I, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation. J Immunol. 2002 Aug 01; 169(3):1270-6. PMID: 12133948.
      View in: PubMed
    52. Zhai Y, Shen XD, Lehmann M, Busuttil R, Volk HD, Kupiec-Weglinski JW. T cell subsets and in vitro immune regulation in "infectious" transplantation tolerance. J Immunol. 2001 Nov 01; 167(9):4814-20. PMID: 11673484.
      View in: PubMed
    53. Zhai Y, Li J, Hammer M, Busuttil RW, Volk HD, Kupiec-Weglinski JW. Evidence of T cell clonality in the infectious tolerance pathway: implications toward identification of regulatory T cells. Transplantation. 2001 Jun 27; 71(12):1701-8. PMID: 11455246.
      View in: PubMed
    54. Kupiec-Weglinski JW, Shen XD, Gao F, Zhai Y, Coito AJ, Sayegh MH. CD40 ligand-CD40 T cell costimulation pathway is required for host sensitization in the immune cascade leading to accelerated allograft rejection. Transplant Proc. 2001 Feb-Mar; 33(1-2):304-5. PMID: 11266829.
      View in: PubMed
    55. Hammer MH, Zhai Y, Katori M, Ritter T, Volk HD, Coito AJ, Kupiec-Weglinski JW. Homing of in vitro-generated donor antigen-reactive CD4+ T lymphocytes to renal allografts is alpha 4 beta 1 but not alpha L beta 2 integrin dependent. J Immunol. 2001 Jan 01; 166(1):596-601. PMID: 11123342.
      View in: PubMed
    56. Ke B, Ritter T, Kato H, Zhai Y, Li J, Lehmann M, Busuttil RW, Volk HD, Kupiec-Weglinski JW. Regulatory cells potentiate the efficacy of IL-4 gene transfer by up-regulating Th2-dependent expression of protective molecules in the infectious tolerance pathway in transplant recipients. J Immunol. 2000 Jun 01; 164(11):5739-45. PMID: 10820251.
      View in: PubMed
    57. Ke B, Coito AJ, Kato H, Zhai Y, Wang T, Sawitzki B, Seu P, Busuttil RW, Kupiec-Weglinski JW. Fas ligand gene transfer prolongs rat renal allograft survival and down-regulates anti-apoptotic Bag-1 in parallel with enhanced Th2-type cytokine expression. Transplantation. 2000 Apr 27; 69(8):1690-4. PMID: 10836382.
      View in: PubMed
    58. Zhai Y, Kupiec-Weglinski JW. What is the role of regulatory T cells in transplantation tolerance? Curr Opin Immunol. 1999 Oct; 11(5):497-503. PMID: 10508706.
      View in: PubMed
    59. Zhai Y, Ghobrial RM, Busuttil RW, Kupiec-Weglinski JW. Th1 and Th2 cytokines in organ transplantation: paradigm lost? Crit Rev Immunol. 1999; 19(2):155-72. PMID: 10352902.
      View in: PubMed