Yuan Zhai

Title(s)Professor-in-Residence, Surgery
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    Glycogen Synthase Kinase 3 beta in liver ischemia reperfusion injury
    NIH R01DK119338May 1, 2020 - Feb 29, 2024
    Role: Principal Investigator
    Kupffer Cell Necroptosis and Homeostatic Function in Liver Immune Responses against Ischemia Reperfusion Injury
    NIH R21AI126516Jun 15, 2016 - May 31, 2018
    Role: Principal Investigator
    CXCL10/CXCR3 Signaling Regulates TLR4-Mediated Liver Inflamation and Injury
    NIH R01DK083408Mar 25, 2010 - Feb 28, 2015
    Role: Principal Investigator
    HuR/HIF ? SIRT1 Signaling Axis in Liver Transplant Rejuvenation
    NIH R01DK062357Jul 1, 2002 - Mar 31, 2026
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ischemia-reperfusion Injury in Allogeneic Liver Transplantation: A Role of CD4 T Cells in Early Allograft Injury. Transplantation. 2021 Sep 01; 105(9):1989-1997. Kageyama S, Kadono K, Hirao H, Nakamura K, Ito T, Gjertson DW, Sosa RA, Reed EF, Kaldas FM, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. PMID: 33065722; PMCID: PMC8046839.
      View in: PubMed   Mentions: 1     Fields:    
    2. T-Cell Immunoglobulin and Mucin Domain-Containing Protein-4 Is Critical for Kupffer Cell Homeostatic Function in the Activation and Resolution of Liver Ischemia Reperfusion Injury. Hepatology. 2021 Oct; 74(4):2118-2132. Ni M, Zhang J, Sosa R, Zhang H, Wang H, Jin D, Crowley K, Naini B, Reed FE, Busuttil RW, Kupiec-Weglinski JW, Wang X, Zhai Y. PMID: 33999437.
      View in: PubMed   Mentions:    Fields:    
    3. Isoform- and Cell Type-Specific Roles of Glycogen Synthase Kinase 3 N-Terminal Serine Phosphorylation in Liver Ischemia Reperfusion Injury. J Immunol. 2020 08 15; 205(4):1147-1156. Ni M, Zhou H, Zhang J, Jin D, Lu T, Busuttil RW, Kupiec-Weglinski JW, Wang X, Zhai Y. PMID: 32680958.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Farnesoid X Receptor Activation Protects Liver From Ischemia/Reperfusion Injury by Up-Regulating Small Heterodimer Partner in Kupffer Cells. Hepatol Commun. 2020 Apr; 4(4):540-554. Jin D, Lu T, Ni M, Wang H, Zhang J, Zhong C, Shen C, Hao J, Busuttil RW, Kupiec-Weglinski JW, Zhang J, Xu N, Zhai Y. PMID: 32258949; PMCID: PMC7109340.
      View in: PubMed   Mentions: 4  
    5. Peacekeepers are cross-dressed in the liver land. Hepatology. 2018 04; 67(4):1221-1223. Zhai Y, Kupiec-Weglinski JW. PMID: 29194675.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Glycogen synthase kinase 3β promotes liver innate immune activation by restraining AMP-activated protein kinase activation. J Hepatol. 2018 07; 69(1):99-109. Zhou H, Wang H, Ni M, Yue S, Xia Y, Busuttil RW, Kupiec-Weglinski JW, Lu L, Wang X, Zhai Y. PMID: 29452207; PMCID: PMC6291010.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    7. Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury. J Immunol. 2017 05 01; 198(9):3588-3595. Yue S, Zhou H, Wang X, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. PMID: 28289160; PMCID: PMC5419828.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    8. Innate Immune Regulations and Liver Ischemia-Reperfusion Injury. Transplantation. 2016 Dec; 100(12):2601-2610. Lu L, Zhou H, Ni M, Wang X, Busuttil R, Kupiec-Weglinski J, Zhai Y. PMID: 27861288; PMCID: PMC5141614.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    9. The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury. Transplantation. 2016 Feb; 100(2):365-72. Zhou H, Zhu J, Yue S, Lu L, Busuttil RW, Kupiec-Weglinski JW, Wang X, Zhai Y. PMID: 26683513; PMCID: PMC4731254.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    10. Rapamycin protection of livers from ischemia and reperfusion injury is dependent on both autophagy induction and mammalian target of rapamycin complex 2-Akt activation. Transplantation. 2015 Jan; 99(1):48-55. Zhu J, Lu T, Yue S, Shen X, Gao F, Busuttil RW, Kupiec-Weglinski JW, Xia Q, Zhai Y. PMID: 25340604; PMCID: PMC4272660.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    11. Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network. Transplantation. 2014 Oct 15; 98(7):721-8. Huang J, Yue S, Ke B, Zhu J, Shen XD, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. PMID: 25171655; PMCID: PMC4188703.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    12. Adoptive transfer of heme oxygenase-1 (HO-1)-modified macrophages rescues the nuclear factor erythroid 2-related factor (Nrf2) antiinflammatory phenotype in liver ischemia/reperfusion injury. Mol Med. 2014 Oct 14; 20:448-55. Huang J, Shen XD, Yue S, Zhu J, Gao F, Zhai Y, Busuttil RW, Ke B, Kupiec-Weglinski JW. PMID: 25014792; PMCID: PMC4212016.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    13. Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation. J Immunol. 2014 Jun 01; 192(11):5343-5353. Yue S, Rao J, Zhu J, Busuttil RW, Kupiec-Weglinski JW, Lu L, Wang X, Zhai Y. PMID: 24771857; PMCID: PMC4033523.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    14. T cells in organ ischemia reperfusion injury. Curr Opin Organ Transplant. 2014 Apr; 19(2):115-20. Rao J, Lu L, Zhai Y. PMID: 24576906; PMCID: PMC4108449.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    15. KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. J Hepatol. 2013 Dec; 59(6):1200-7. Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. PMID: 23867319; PMCID: PMC4524560.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    16. Ischaemia-reperfusion injury in liver transplantation--from bench to bedside. Nat Rev Gastroenterol Hepatol. 2013 Feb; 10(2):79-89. Zhai Y, Petrowsky H, Hong JC, Busuttil RW, Kupiec-Weglinski JW. PMID: 23229329; PMCID: PMC3577927.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansAnimalsCells
    17. Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury. Transplantation. 2012 Aug 15; 94(3):211-7. Liu J, Ren F, Cheng Q, Bai L, Shen X, Gao F, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. PMID: 22790388; PMCID: PMC3414672.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    18. Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism. Hepatology. 2011 Aug; 54(2):687-96. Ren F, Duan Z, Cheng Q, Shen X, Gao F, Bai L, Liu J, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. PMID: 21567437; PMCID: PMC3145016.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    19. Alloreactive CD8 T-cell primed/memory responses and accelerated graft rejection in B-cell-deficient sensitized mice. Transplantation. 2011 May 27; 91(10):1075-81. Ji H, Shen XD, Gao F, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. PMID: 21427633; PMCID: PMC3593653.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    20. Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury. Liver Transpl. 2011 Feb; 17(2):201-10. Shen XD, Ke B, Uchida Y, Ji H, Gao F, Zhai Y, Busuttil RW, Kupiec-Weglinski JW. PMID: 21280193; PMCID: PMC3058297.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    21. Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury. Hepatology. 2010 Oct; 52(4):1380-9. Ji H, Shen X, Gao F, Ke B, Freitas MC, Uchida Y, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. PMID: 20815020; PMCID: PMC2947605.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    22. Adoptive transfer of ex vivo HO-1 modified bone marrow-derived macrophages prevents liver ischemia and reperfusion injury. Mol Ther. 2010 May; 18(5):1019-25. Ke B, Shen XD, Gao F, Ji H, Qiao B, Zhai Y, Farmer DG, Busuttil RW, Kupiec-Weglinski JW. PMID: 20029397; PMCID: PMC2890105.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    23. CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury. Hepatology. 2009 Nov; 50(5):1537-46. Shen X, Wang Y, Gao F, Ren F, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. PMID: 19670423; PMCID: PMC2805281.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    24. Intragraft selection of the T cell receptor repertoire by class I MHC sequences in tolerant recipients. PLoS One. 2009 Jun 29; 4(6):e6076. Liu D, Shen XD, Zhai Y, Lam W, Liao J, Busuttil RW, Ghobrial RM. PMID: 19562081; PMCID: PMC2700265.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    25. Critical role of CD4 help in CD154 blockade-resistant memory CD8 T cell activation and allograft rejection in sensitized recipients. J Immunol. 2008 Jul 15; 181(2):1096-102. Wu Z, Wang Y, Gao F, Shen X, Zhai Y, Kupiec-Weglinski JW. PMID: 18606661; PMCID: PMC2975478.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. Differential impact of CD154 costimulation blockade on alloreactive effector and regulatory T cells in murine renal transplant recipients. Transplantation. 2008 May 15; 85(9):1332-8. Meng L, Wu Z, Wang Y, Lassman C, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. PMID: 18475192.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    27. Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury. Transplantation. 2008 Apr 15; 85(7):1016-22. Zhai Y, Qiao B, Shen XD, Gao F, Busuttil RW, Cheng G, Platt JL, Volk HD, Kupiec-Weglinski JW. PMID: 18408583.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    28. Type I, but not type II, interferon is critical in liver injury induced after ischemia and reperfusion. Hepatology. 2008 Jan; 47(1):199-206. Zhai Y, Qiao B, Gao F, Shen X, Vardanian A, Busuttil RW, Kupiec-Weglinski JW. PMID: 17935177.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    29. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Hepatology. 2008 Jan; 47(1):207-14. Zhai Y, Shen XD, Gao F, Zhao A, Freitas MC, Lassman C, Luster AD, Busuttil RW, Kupiec-Weglinski JW. PMID: 18041715.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    30. Defective alloreactive CD8 T cell function and memory response in allograft recipients in the absence of CD4 help. J Immunol. 2007 Oct 01; 179(7):4529-34. Zhai Y, Wang Y, Wu Z, Kupiec-Weglinski JW. PMID: 17878349.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    31. Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model. Liver Transpl. 2007 Oct; 13(10):1435-43. Shen XD, Ke B, Zhai Y, Gao F, Tsuchihashi S, Lassman CR, Busuttil RW, Kupiec-Weglinski JW. PMID: 17902130.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    32. Heme oxygenase-1 mediated cytoprotection against liver ischemia and reperfusion injury: inhibition of type-1 interferon signaling. Transplantation. 2007 Jun 27; 83(12):1628-34. Tsuchihashi S, Zhai Y, Bo Q, Busuttil RW, Kupiec-Weglinski JW. PMID: 17589347.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    33. Basal rather than induced heme oxygenase-1 levels are crucial in the antioxidant cytoprotection. J Immunol. 2006 Oct 01; 177(7):4749-57. Tsuchihashi S, Livhits M, Zhai Y, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. PMID: 16982915.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    34. CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent. J Immunol. 2006 May 15; 176(10):5988-94. Zhai Y, Meng L, Gao F, Wang Y, Busuttil RW, Kupiec-Weglinski JW. PMID: 16670307.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    35. CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury. J Immunol. 2006 May 15; 176(10):6313-22. Zhai Y, Shen XD, Hancock WW, Gao F, Qiao B, Lassman C, Belperio JA, Strieter RM, Busuttil RW, Kupiec-Weglinski JW. PMID: 16670343.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    36. Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation. Liver Transpl. 2005 Oct; 11(10):1273-81. Shen XD, Gao F, Ke B, Zhai Y, Lassman CR, Tsuchihashi S, Farmer DG, Busuttil RW, Kupiec-Weglinski JW. PMID: 16184555.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    37. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant. 2005 Aug; 5(8):1793-800. Shen XD, Ke B, Zhai Y, Gao F, Busuttil RW, Cheng G, Kupiec-Weglinski JW. PMID: 15996225.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    38. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol. 2004 Dec 15; 173(12):7115-9. Zhai Y, Shen XD, O'Connell R, Gao F, Lassman C, Busuttil RW, Cheng G, Kupiec-Weglinski JW. PMID: 15585830.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    39. Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol. 2003 Aug 01; 171(3):1572-80. Araujo JA, Meng L, Tward AD, Hancock WW, Zhai Y, Lee A, Ishikawa K, Iyer S, Buelow R, Busuttil RW, Shih DM, Lusis AJ, Kupiec-Weglinski JW. PMID: 12874251.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    40. Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive. J Immunol. 2003 Mar 15; 170(6):3024-8. Zhai Y, Meng L, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. PMID: 12626556.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    41. T-cell receptor beta-chain usage in directly activated alloreactive CD4+ T cells: unrestricted Vbeta gene usage with CDR3 size limitations. Transplantation. 2003 Feb 27; 75(4):514-21. Zhai Y, Kupiec-Weglinski JW. PMID: 12605120.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    42. Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection. Hepatology. 2003 Feb; 37(2):296-303. Shen XD, Ke B, Zhai Y, Gao F, Anselmo D, Lassman CR, Busuttil RW, Kupiec-Weglinski JW. PMID: 12540779.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    43. Allograft rejection by primed/memory CD8+ T cells is CD154 blockade resistant: therapeutic implications for sensitized transplant recipients. J Immunol. 2002 Oct 15; 169(8):4667-73. Zhai Y, Meng L, Gao F, Busuttil RW, Kupiec-Weglinski JW. PMID: 12370407.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCellsPHPublic Health
    44. Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Hum Gene Ther. 2002 Oct 10; 13(15):1845-57. Ke B, Shen XD, Zhai Y, Gao F, Busuttil RW, Volk HD, Kupiec-Weglinski JW. PMID: 12396617.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    45. The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation. J Immunol. 2002 Aug 01; 169(3):1270-6. Zhai Y, Shen XD, Gao F, Coito AJ, Wasowska BA, Salama A, Schmitt I, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. PMID: 12133948.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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