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Zhenfeng Duan

Title(s)Professor-in-Residence, Orthopaedic Surgery
SchoolMedicine
Address760 Westwood Plaza 76-143
Los Angeles CA 90024
Phone3103191234
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The role of extracelluar matrix in osteosarcoma progression and metastasis. J Exp Clin Cancer Res. 2020 Sep 04; 39(1):178. Cui J, Dean D, Hornicek FJ, Chen Z, Duan Z. PMID: 32887645.
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    2. PTEN in osteosarcoma: Recent advances and the therapeutic potential. Biochim Biophys Acta Rev Cancer. 2020 Aug 19; 1874(2):188405. Zheng C, Tang F, Min L, Hornicek F, Duan Z, Tu C. PMID: 32827577.
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    3. Cyclin-dependent kinase 12 (CDK12) in chordoma: prognostic and therapeutic value. Eur Spine J. 2020 Jul 20. Thanindratarn P, Dean DC, Feng W, Wei R, Nelson SD, Hornicek FJ, Duan Z. PMID: 32691223.
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    4. Myc is a prognostic biomarker and potential therapeutic target in osteosarcoma. Ther Adv Med Oncol. 2020; 12:1758835920922055. Feng W, Dean DC, Hornicek FJ, Spentzos D, Hoffman RM, Shi H, Duan Z. PMID: 32426053.
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    5. Cyclin E1 is a prognostic biomarker and potential therapeutic target in osteosarcoma. J Orthop Res. 2020 Sep; 38(9):1952-1964. Wei R, Thanindratarn P, Dean DC, Hornicek FJ, Guo W, Duan Z. PMID: 32162720.
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    6. Corrigendum to "HER4 promotes cell survival and chemoresistance in osteosarcoma via interaction with NDRG1" [Biochim. Biophys. Acta Mol. Basis Dis. 1864 (2018) 1839-1849]. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 01; 1866(6):165755. Wang H, Sun W, Sun M, Fu Z, Zhou C, Wang C, Zuo D, Zhou Z, Wang G, Zhang T, Xu J, Chen J, Wang Z, Yin F, Duan Z, Hornicek FJ, Cai Z, Hua Y. PMID: 32173158.
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    7. MicroRNA-mRNA networks define translatable molecular outcome phenotypes in osteosarcoma. Sci Rep. 2020 03 10; 10(1):4409. Lietz CE, Garbutt C, Barry WT, Deshpande V, Chen YL, Lozano-Calderon SA, Wang Y, Lawney B, Ebb D, Cote GM, Duan Z, Hornicek FJ, Choy E, Petur Nielsen G, Haibe-Kains B, Quackenbush J, Spentzos D. PMID: 32157112.
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    8. Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute-On-Chronic Liver Failure. Adv Sci (Weinh). 2020 Apr; 7(7):1902996. Yu Z, Li J, Ren Z, Sun R, Zhou Y, Zhang Q, Wang Q, Cui G, Li J, Li A, Duan Z, Xu Y, Wang Z, Yin P, Piao H, Lv J, Liu X, Wang Y, Fang M, Zhuang Z, Xu G, Kan Q. PMID: 32274306.
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    9. Diagnosis, Therapy, and Prognosis for Hepatocellular Carcinoma. Anal Cell Pathol (Amst). 2020; 2020:8157406. Ren Z, Ma X, Duan Z, Chen X. PMID: 32089989.
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    10. Emerging next-generation sequencing-based discoveries for targeted osteosarcoma therapy. Cancer Lett. 2020 Apr 01; 474:158-167. Zhao J, Dean DC, Hornicek FJ, Yu X, Duan Z. PMID: 31987920.
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    11. Aberrant CDK9 expression within chordoma tissues and the therapeutic potential of a selective CDK9 inhibitor LDC000067. J Cancer. 2020; 11(1):132-141. Shen S, Dean DC, Yu Z, Hornicek F, Kan Q, Duan Z. PMID: 31892980.
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    12. Establishment and Characterization of a Recurrent Osteosarcoma Cell Line: OSA 1777. J Orthop Res. 2020 04; 38(4):902-910. Thanindratarn P, Li X, Dean DC, Nelson SD, Hornicek FJ, Duan Z. PMID: 31736134.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Chimeric antigen receptor T (CAR-T) cell immunotherapy for sarcomas: From mechanisms to potential clinical applications. Cancer Treat Rev. 2020 Jan; 82:101934. Thanindratarn P, Dean DC, Nelson SD, Hornicek FJ, Duan Z. PMID: 31794912.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Correction to: Transcriptional activation of CBFß by CDK11p110 is necessary to promote osteosarcoma cell proliferation. Cell Commun Signal. 2019 Oct 29; 17(1):138. Feng Y, Liao Y, Zhang J, Shen J, Shao Z, Hornicek F, Duan Z. PMID: 31665012.
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    15. Cancer testis antigens in sarcoma: Expression, function and immunotherapeutic application. Cancer Lett. 2020 Jun 01; 479:54-60. Wei R, Dean DC, Thanindratarn P, Hornicek FJ, Guo W, Duan Z. PMID: 31634526.
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    16. Transcriptional activation of CBFß by CDK11p110 is necessary to promote osteosarcoma cell proliferation. Cell Commun Signal. 2019 10 14; 17(1):125. Feng Y, Liao Y, Zhang J, Shen J, Shao Z, Hornicek F, Duan Z. PMID: 31610798.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Exosomes promote pre-metastatic niche formation in ovarian cancer. Mol Cancer. 2019 08 13; 18(1):124. Feng W, Dean DC, Hornicek FJ, Shi H, Duan Z. PMID: 31409361.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. Role of cyclin-dependent kinases (CDKs) in hepatocellular carcinoma: Therapeutic potential of targeting the CDK signaling pathway. Hepatol Res. 2019 Oct; 49(10):1097-1108. Shen S, Dean DC, Yu Z, Duan Z. PMID: 31009153.
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    19. miR3609 sensitizes breast cancer cells to adriamycin by blocking the programmed death-ligand 1 immune checkpoint. Exp Cell Res. 2019 07 01; 380(1):20-28. Li D, Wang X, Yang M, Kan Q, Duan Z. PMID: 30904483.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer. Mol Cancer. 2019 03 02; 18(1):33. Chen J, Yu Y, Li H, Hu Q, Chen X, He Y, Xue C, Ren F, Ren Z, Li J, Liu L, Duan Z, Cui G, Sun R. PMID: 30825877.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    21. Anlotinib, a novel small molecular tyrosine kinase inhibitor, suppresses growth and metastasis via dual blockade of VEGFR2 and MET in osteosarcoma. Int J Cancer. 2019 08 15; 145(4):979-993. Wang G, Sun M, Jiang Y, Zhang T, Sun W, Wang H, Yin F, Wang Z, Sang W, Xu J, Mao M, Zuo D, Zhou Z, Wang C, Fu Z, Wang Z, Duan Z, Hua Y, Cai Z. PMID: 30719715.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. Targeting mutant TP53 as a potential therapeutic strategy for the treatment of osteosarcoma. J Orthop Res. 2019 03; 37(3):789-798. Tang F, Min L, Seebacher NA, Li X, Zhou Y, Hornicek FJ, Wei Y, Tu C, Duan Z. PMID: 30667081.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in ovarian cancer. FASEB J. 2019 05; 33(5):5990-6000. Wang J, Dean DC, Hornicek FJ, Shi H, Duan Z. PMID: 30726104.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    24. Advances in immune checkpoint inhibitors for bone sarcoma therapy. J Bone Oncol. 2019 Apr; 15:100221. Thanindratarn P, Dean DC, Nelson SD, Hornicek FJ, Duan Z. PMID: 30775238.
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    25. Targeting regulation of cyclin dependent kinase 9 as a novel therapeutic strategy in synovial sarcoma. J Orthop Res. 2019 02; 37(2):510-521. Li X, Seebacher NA, Xiao T, Hornicek FJ, Duan Z. PMID: 30488489.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma. EBioMedicine. 2019 Jan; 39:182-193. Ma H, Seebacher NA, Hornicek FJ, Duan Z. PMID: 30579871.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. From genomics to metabolomics: emerging metastatic biomarkers in osteosarcoma. Cancer Metastasis Rev. 2018 12; 37(4):719-731. Dean DC, Shen S, Hornicek FJ, Duan Z. PMID: 30167827.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    28. RNA sequencing (RNA-Seq) and its application in ovarian cancer. Gynecol Oncol. 2019 01; 152(1):194-201. Wang J, Dean DC, Hornicek FJ, Shi H, Duan Z. PMID: 30297273.
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    29. Application of liquid biopsy in bone and soft tissue sarcomas: Present and future. Cancer Lett. 2018 12 28; 439:66-77. Li X, Seebacher NA, Hornicek FJ, Xiao T, Duan Z. PMID: 30223067.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma. Cell Prolif. 2018 Dec; 51(6):e12510. Chen J, Yu Y, Chen X, He Y, Hu Q, Li H, Han Q, Ren F, Li J, Li C, Bao J, Ren Z, Duan Z, Cui G, Sun R. PMID: 30105813.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    31. Author Correction: Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11. Sci Rep. 2018 Aug 09; 8(1):12107. Liao Y, Sassi S, Halvorsen S, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. PMID: 30093700.
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    32. Inhibition of cyclin-dependent kinase 4 as a potential therapeutic strategy for treatment of synovial sarcoma. Cell Death Dis. 2018 05 01; 9(5):446. Li X, Seebacher NA, Garbutt C, Ma H, Gao P, Xiao T, Hornicek FJ, Duan Z. PMID: 29670090.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    33. Expression and role of autophagy-associated p62 (SQSTM1) in multidrug resistant ovarian cancer. Gynecol Oncol. 2018 07; 150(1):143-150. Wang J, Garbutt C, Ma H, Gao P, Hornicek FJ, Kan Q, Shi H, Duan Z. PMID: 29699801.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    34. CRISPR-Cas9-Mediated Silencing of CD44 in Human Highly Metastatic Osteosarcoma Cells. Cell Physiol Biochem. 2018; 46(3):1218-1230. Liu T, Yan Z, Liu Y, Choy E, Hornicek FJ, Mankin H, Duan Z. PMID: 29672299.
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    35. Expression and Clinical Implication of Autophagy-Associated Protein p62 in Osteosarcoma. Oncology. 2018; 95(1):52-60. Ma H, Li X, Wang J, Hornicek FJ, Garbutt CC, Chang X, Duan Z. PMID: 29617702.
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    36. HER4 promotes cell survival and chemoresistance in osteosarcoma via interaction with NDRG1. Biochim Biophys Acta Mol Basis Dis. 2018 May; 1864(5 Pt A):1839-1849. Wang H, Sun W, Sun M, Fu Z, Zhou C, Wang C, Zuo D, Zhou Z, Wang G, Zhang T, Xu J, Chen J, Wang Z, Yin F, Duan Z, Hornicek FJ, Cai Z, Hua Y. PMID: 29524631.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    37. Expression and therapeutic implications of cyclin-dependent kinase 4 (CDK4) in osteosarcoma. Biochim Biophys Acta Mol Basis Dis. 2018 May; 1864(5 Pt A):1573-1582. Zhou Y, Shen JK, Yu Z, Hornicek FJ, Kan Q, Duan Z. PMID: 29452249.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    38. CDK4 expression in chordoma: A potential therapeutic target. J Orthop Res. 2018 06; 36(6):1581-1589. Liu T, Shen JK, Choy E, Zhang Y, Mankin HJ, Hornicek FJ, Duan Z. PMID: 29194728.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    39. Advances in chromosomal translocations and fusion genes in sarcomas and potential therapeutic applications. Cancer Treat Rev. 2018 Feb; 63:61-70. Xiao X, Garbutt CC, Hornicek F, Guo Z, Duan Z. PMID: 29247978.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    40. Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells. Oncotarget. 2018 Mar 02; 9(17):13154-13166. Chen H, Shen J, Choy E, Hornicek FJ, Shan A, Duan Z. PMID: 29568347.
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    41. Advances in sarcoma gene mutations and therapeutic targets. Cancer Treat Rev. 2018 Jan; 62:98-109. Gao P, Seebacher NA, Hornicek F, Guo Z, Duan Z. PMID: 29190505.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    42. Regulation of microRNAs function by circular RNAs in human cancer. Oncotarget. 2017 Sep 08; 8(38):64622-64637. Han C, Seebacher NA, Hornicek FJ, Kan Q, Duan Z. PMID: 28969099.
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    43. Three-dimensional (3D) culture in sarcoma research and the clinical significance. Biofabrication. 2017 Aug 03; 9(3):032003. Gao S, Shen J, Hornicek F, Duan Z. PMID: 28707624.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    44. Novel strategies to prevent the development of multidrug resistance (MDR) in cancer. Oncotarget. 2017 Oct 13; 8(48):84559-84571. Wang J, Seebacher N, Shi H, Kan Q, Duan Z. PMID: 29137448.
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    45. Noncoding RNA in drug resistant sarcoma. Oncotarget. 2017 Sep 15; 8(40):69086-69104. Li X, Shen JK, Hornicek FJ, Xiao T, Duan Z. PMID: 28978183.
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    46. Therapeutic applications of histone deacetylase inhibitors in sarcoma. Cancer Treat Rev. 2017 Sep; 59:33-45. Tang F, Choy E, Tu C, Hornicek F, Duan Z. PMID: 28732326.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    47. Expression and Therapeutic Potential of SOX9 in Chordoma. Clin Cancer Res. 2017 Sep 01; 23(17):5176-5186. Chen H, Garbutt CC, Spentzos D, Choy E, Hornicek FJ, Duan Z. PMID: 28606919.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    48. Aberration of p73 Promoter Methylation in Chondrosarcoma. Anticancer Res. 2017 06; 37(6):2939-2945. Liu P, Garbutt C, Hornicek FJ, Liu F, Duan Z. PMID: 28551631.
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    49. An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets. J Hematol Oncol. 2017 05 15; 10(1):107. Hill KE, Kelly AD, Kuijjer ML, Barry W, Rattani A, Garbutt CC, Kissick H, Janeway K, Perez-Atayde A, Goldsmith J, Gebhardt MC, Arredouani MS, Cote G, Hornicek F, Choy E, Duan Z, Quackenbush J, Haibe-Kains B, Spentzos D. PMID: 28506242.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    50. Application of metabolomics in sarcoma: From biomarkers to therapeutic targets. Crit Rev Oncol Hematol. 2017 08; 116:1-10. Min L, Choy E, Tu C, Hornicek F, Duan Z. PMID: 28693790.
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    51. Wnt inhibitory factor 1 (WIF1) methylation and its association with clinical prognosis in patients with chondrosarcoma. Sci Rep. 2017 05 08; 7(1):1580. Liu P, Shen JK, Hornicek FJ, Liu F, Duan Z. PMID: 28484252.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    52. Targeting programmed cell death ligand 1 by CRISPR/Cas9 in osteosarcoma cells. Oncotarget. 2017 May 02; 8(18):30276-30287. Liao Y, Chen L, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. PMID: 28415820.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    53. Potentials of Long Noncoding RNAs (LncRNAs) in Sarcoma: From Biomarkers to Therapeutic Targets. Int J Mol Sci. 2017 Mar 29; 18(4). Min L, Garbutt C, Tu C, Hornicek F, Duan Z. PMID: 28353666.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    54. Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11. Sci Rep. 2017 03 06; 7:43941. Liao Y, Sassi S, Halvorsen S, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. PMID: 28262798.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    55. Inhibition of CDK4 sensitizes multidrug resistant ovarian cancer cells to paclitaxel by increasing apoptosiss. Cell Oncol (Dordr). 2017 Jun; 40(3):209-218. Gao Y, Shen J, Choy E, Mankin H, Hornicek F, Duan Z. PMID: 28243976.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    56. Autophagy as a potential target for sarcoma treatment. Biochim Biophys Acta Rev Cancer. 2017 Aug; 1868(1):40-50. Min L, Choy E, Pollock RE, Tu C, Hornicek F, Duan Z. PMID: 28242349.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    57. Facial Layer-by-Layer Engineering of Upconversion Nanoparticles for Gene Delivery: Near-Infrared-Initiated Fluorescence Resonance Energy Transfer Tracking and Overcoming Drug Resistance in Ovarian Cancer. ACS Appl Mater Interfaces. 2017 Mar 08; 9(9):7941-7949. Lin M, Gao Y, Diefenbach TJ, Shen JK, Hornicek FJ, Park YI, Xu F, Lu TJ, Amiji M, Duan Z. PMID: 28177223.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    58. Targeting ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the CRISPR-Cas9 system to reverse drug resistance. Oncotarget. 2016 Dec 13; 7(50):83502-83513. Liu T, Li Z, Zhang Q, De Amorim Bernstein K, Lozano-Calderon S, Choy E, Hornicek FJ, Duan Z. PMID: 27835872.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    59. Regulation of microRNA-1 (miR-1) expression in human cancer. Biochim Biophys Acta Gene Regul Mech. 2017 Feb; 1860(2):227-232. Han C, Shen JK, Hornicek FJ, Kan Q, Duan Z. PMID: 27923712.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    60. miR-15b modulates multidrug resistance in human osteosarcoma in vitro and in vivo. Mol Oncol. 2017 02; 11(2):151-166. Duan Z, Gao Y, Shen J, Choy E, Cote G, Harmon D, Bernstein K, Lozano-Calderon S, Mankin H, Hornicek FJ. PMID: 28145098.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    61. Novel mechanisms and approaches to overcome multidrug resistance in the treatment of ovarian cancer. Biochim Biophys Acta. 2016 12; 1866(2):266-275. Ren F, Shen J, Shi H, Hornicek FJ, Kan Q, Duan Z. PMID: 27717733.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    62. Aberrant DNA methylations in chondrosarcoma. Epigenomics. 2016 11; 8(11):1519-1525. Liu P, Shen JK, Xu J, Trahan CA, Hornicek FJ, Duan Z. PMID: 27686001.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    63. Matrine induces cell cycle arrest and apoptosis with recovery of the expression of miR-126 in the A549 non-small cell lung cancer cell line. Mol Med Rep. 2016 Nov; 14(5):4042-4048. An Q, Han C, Zhou Y, Li F, Li D, Zhang X, Yu Z, Duan Z, Kan Q. PMID: 27665734.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    64. CD151-mediated adhesion is crucial to osteosarcoma pulmonary metastasis. Oncotarget. 2016 Sep 13; 7(37):60623-60638. Wang Z, Wang C, Zhou Z, Sun M, Zhou C, Chen J, Yin F, Wang H, Lin B, Zuo D, Li S, Feng L, Duan Z, Cai Z, Hua Y. PMID: 27556355.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    65. The roles and implications of exosomes in sarcoma. Cancer Metastasis Rev. 2016 09; 35(3):377-90. Min L, Shen J, Tu C, Hornicek F, Duan Z. PMID: 27342745.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    66. The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. Oncotarget. 2016 Jun 28; 7(26):40846-40859. Zhou Y, Shen JK, Hornicek FJ, Kan Q, Duan Z. PMID: 27049727.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    67. Overexpression of EZH2 is associated with the poor prognosis in osteosarcoma and function analysis indicates a therapeutic potential. Oncotarget. 2016 Jun 21; 7(25):38333-38346. Sun R, Shen J, Gao Y, Zhou Y, Yu Z, Hornicek F, Kan Q, Duan Z. PMID: 27223261.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    68. The roles and therapeutic potential of cyclin-dependent kinases (CDKs) in sarcoma. Cancer Metastasis Rev. 2016 06; 35(2):151-63. Liao Y, Feng Y, Shen J, Hornicek FJ, Duan Z. PMID: 26669603.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    69. Cyclin-Dependent Kinase 11 (CDK11) Is Required for Ovarian Cancer Cell Growth In Vitro and In Vivo, and Its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel. Mol Cancer Ther. 2016 07; 15(7):1691-701. Liu X, Gao Y, Shen J, Yang W, Choy E, Mankin H, Hornicek FJ, Duan Z. PMID: 27207777.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    70. Pharmacokinetics and tolerability of NSC23925b, a novel P-glycoprotein inhibitor: preclinical study in mice and rats. Sci Rep. 2016 05 09; 6:25659. Gao Y, Shen JK, Choy E, Zhang Z, Mankin HJ, Hornicek FJ, Duan Z. PMID: 27157103.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    71. Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro. Sci Rep. 2016 04 29; 6:25239. Shen JK, Cote GM, Gao Y, Choy E, Mankin HJ, Hornicek FJ, Duan Z. PMID: 27125524.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    72. Evaluation of P-glycoprotein (Pgp) expression in human osteosarcoma by high-throughput tissue microarray. J Orthop Res. 2016 09; 34(9):1606-12. Gao Y, Liao Y, Shen JK, Feng Y, Choy E, Cote G, Harmon D, Mankin HJ, Hornicek FJ, Duan Z. PMID: 26790551.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    73. Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma. Cancer Lett. 2016 Apr 01; 373(1):109-118. Liu T, Shen JK, Li Z, Choy E, Hornicek FJ, Duan Z. PMID: 26806808.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    74. NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function. Br J Pharmacol. 2016 Feb; 173(3):613-26. Ye S, Zhang J, Shen J, Gao Y, Li Y, Choy E, Cote G, Harmon D, Mankin H, Gray NS, Hornicek FJ, Duan Z. PMID: 26603906.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    75. The Roles of Sox Family Genes in Sarcoma. Curr Drug Targets. 2016; 17(15):1761-1772. Li J, Shen J, Wang K, Hornicek F, Duan Z. PMID: 27138764.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    76. Clinical and biological significance of PIM1 kinase in osteosarcoma. J Orthop Res. 2016 07; 34(7):1185-94. Liao Y, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. PMID: 26687194.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    77. p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines. Cancer Chemother Pharmacol. 2016 Feb; 77(2):349-56. Ye S, Shen J, Choy E, Yang C, Mankin H, Hornicek F, Duan Z. PMID: 26698867.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
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    79. Targeting protein kinases to reverse multidrug resistance in sarcoma. Cancer Treat Rev. 2016 Feb; 43:8-18. Chen H, Shen J, Choy E, Hornicek FJ, Duan Z. PMID: 26827688.
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    80. In vitro effects of mitomycin C on the proliferation of the non-small-cell lung cancer line A549. Int J Clin Exp Med. 2015; 8(11):20516-23. An Q, Han C, Zhou Y, Li F, Li D, Zhang X, Yu Z, Duan Z, Kan Q. PMID: 26884968.
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    82. Near-infrared light activated delivery platform for cancer therapy. Adv Colloid Interface Sci. 2015 Dec; 226(Pt B):123-37. Lin M, Gao Y, Hornicek F, Xu F, Lu TJ, Amiji M, Duan Z. PMID: 26520243.
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    83. Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. Sarcoma. 2015; 2015:232010. Sun X, Guo W, Shen JK, Mankin HJ, Hornicek FJ, Duan Z. PMID: 26420980.
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    86. Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma. Oncotarget. 2015 May 10; 6(13):11139-49. Feng Y, Shen J, Gao Y, Liao Y, Cote G, Choy E, Chebib I, Mankin H, Hornicek F, Duan Z. PMID: 25871477.
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    87. Nsc23925 prevents the development of paclitaxel resistance by inhibiting the introduction of P-glycoprotein and enhancing apoptosis. Int J Cancer. 2015 Oct 15; 137(8):2029-39. Yang X, Shen J, Gao Y, Feng Y, Guan Y, Zhang Z, Mankin H, Hornicek FJ, Duan Z. PMID: 25904021.
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    89. Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer. Oncotarget. 2015 Apr 20; 6(11):9313-26. Gao Y, Foster R, Yang X, Feng Y, Shen JK, Mankin HJ, Hornicek FJ, Amiji MM, Duan Z. PMID: 25823654.
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    90. Polymeric nanoparticle-based delivery of microRNA-199a-3p inhibits proliferation and growth of osteosarcoma cells. Int J Nanomedicine. 2015; 10:2913-24. Zhang L, Lyer AK, Yang X, Kobayashi E, Guo Y, Mankin H, Hornicek FJ, Amiji MM, Duan Z. PMID: 25931818.
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    91. MicroRNA-1 (miR-1) inhibits gastric cancer cell proliferation and migration by targeting MET. Tumour Biol. 2015 Sep; 36(9):6715-23. Han C, Zhou Y, An Q, Li F, Li D, Zhang X, Yu Z, Zheng L, Duan Z, Kan Q. PMID: 25874496.
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    92. Decreased expression and activation of Stat3 in severe preeclampsia. J Mol Histol. 2015 Apr; 46(2):205-19. Zhang Z, Yang X, Zhang L, Duan Z, Jia L, Wang P, Shi Y, Li Y, Gao J. PMID: 25752465.
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    93. MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer. Sci Rep. 2015 Feb 17; 5:8509. Yang X, Iyer AK, Singh A, Choy E, Hornicek FJ, Amiji MM, Duan Z. PMID: 25687880.
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    95. Targeted cancer therapy; nanotechnology approaches for overcoming drug resistance. Curr Med Chem. 2015; 22(11):1335-47. Gao Y, Shen JK, Milane L, Hornicek FJ, Amiji MM, Duan Z. PMID: 25666804.
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    96. Phase 1 study of oral abexinostat, a histone deacetylase inhibitor, in combination with doxorubicin in patients with metastatic sarcoma. Cancer. 2015 Apr 15; 121(8):1223-30. Choy E, Flamand Y, Balasubramanian S, Butrynski JE, Harmon DC, George S, Cote GM, Wagner AJ, Morgan JA, Sirisawad M, Mani C, Hornicek FJ, Duan Z, Demetri GD. PMID: 25536954.
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    98. Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system. J Orthop Res. 2015 Feb; 33(2):199-207. Feng Y, Sassi S, Shen JK, Yang X, Gao Y, Osaka E, Zhang J, Yang S, Yang C, Mankin HJ, Hornicek FJ, Duan Z. PMID: 25348612.
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    99. A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells. BMC Cancer. 2014 Sep 19; 14:681. Duan Z, Zhang J, Ye S, Shen J, Choy E, Cote G, Harmon D, Mankin H, Hua Y, Zhang Y, Gray NS, Hornicek FJ. PMID: 25236161.
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    100. Targeting programmed cell death ligand 1 in osteosarcoma: an auto-commentary on therapeutic potential. Oncoimmunology. 2014; 3(8):e954467. Shen JK, Cote GM, Choy E, Hornicek FJ, Duan Z. PMID: 25610746.
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    102. Role of microRNA-1 in human cancer and its therapeutic potentials. Biomed Res Int. 2014; 2014:428371. Han C, Yu Z, Duan Z, Kan Q. PMID: 24949449.
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    103. MicroRNA-1 (miR-1) inhibits chordoma cell migration and invasion by targeting slug. J Orthop Res. 2014 Aug; 32(8):1075-82. Osaka E, Yang X, Shen JK, Yang P, Feng Y, Mankin HJ, Hornicek FJ, Duan Z. PMID: 24760686.
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    104. Programmed cell death ligand 1 expression in osteosarcoma. Cancer Immunol Res. 2014 Jul; 2(7):690-698. Shen JK, Cote GM, Choy E, Yang P, Harmon D, Schwab J, Nielsen GP, Chebib I, Ferrone S, Wang X, Wang Y, Mankin H, Hornicek FJ, Duan Z. PMID: 24866169.
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    105. Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma. PLoS One. 2014; 9(4):e93996. Guo S, Lopez-Marquez H, Fan KC, Choy E, Cote G, Harmon D, Nielsen GP, Yang C, Zhang C, Mankin H, Hornicek FJ, Borger DR, Duan Z. PMID: 24695632.
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    106. Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma. J Orthop Res. 2014 May; 32(5):695-701. Duan Z, Shen J, Yang X, Yang P, Osaka E, Choy E, Cote G, Harmon D, Zhang Y, Nielsen GP, Spentzos D, Mankin H, Hornicek F. PMID: 24501096.
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    107. BRAF mutation in 'sarcomas': a possible method to detect de-differentiated melanomas. Histopathology. 2014 Apr; 64(5):639-46. Cipriani NA, Letovanec I, Hornicek FJ, Mullen JT, Duan Z, Borger DR, Nielsen GP. PMID: 24117833.
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    108. Development of a new pre-vascularized tissue-engineered construct using pre-differentiated rADSCs, arteriovenous vascular bundle and porous nano-hydroxyapatide-polyamide 66 scaffold. BMC Musculoskelet Disord. 2013 Nov 08; 14:318. Yang P, Huang X, Shen J, Wang C, Dang X, Mankin H, Duan Z, Wang K. PMID: 24209783.
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    110. Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells. Cancer Lett. 2014 Jan 01; 342(1):104-12. Jia B, Choy E, Cote G, Harmon D, Ye S, Kan Q, Mankin H, Hornicek F, Duan Z. PMID: 24007862.
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    111. Molecular distinction of chondrosarcoma from chondroblastic osteosarcoma through IDH1/2 mutations. Am J Surg Pathol. 2013 Jun; 37(6):787-95. Kerr DA, Lopez HU, Deshpande V, Hornicek FJ, Duan Z, Zhang Y, Rosenberg AE, Borger DR, Nielsen GP. PMID: 23598960.
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    112. Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: a pilot study. Clin Orthop Relat Res. 2013 Mar; 471(3):915-25. Kobayashi E, Iyer AK, Hornicek FJ, Amiji MM, Duan Z. PMID: 23011844.
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    114. Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation. Clin Cancer Res. 2012 Sep 01; 18(17):4580-8. Duan Z, Zhang J, Choy E, Harmon D, Liu X, Nielsen P, Mankin H, Gray NS, Hornicek FJ. PMID: 22791884.
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    115. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev. 2012 Nov; 38(7):904-10. Guo Y, Xu F, Lu T, Duan Z, Zhang Z. PMID: 22651903.
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    120. Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer. PLoS One. 2011; 6(9):e24075. Milane L, Duan Z, Amiji M. PMID: 21931642.
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    121. MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. Mol Cancer Ther. 2011 Aug; 10(8):1337-45. Duan Z, Choy E, Harmon D, Liu X, Susa M, Mankin H, Hornicek F. PMID: 21666078.
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    122. Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo. Anticancer Drugs. 2011 Jun; 22(5):444-53. Liu X, Choy E, Harmon D, Yang S, Yang C, Mankin H, Hornicek FJ, Duan Z. PMID: 21399492.
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    123. Recurrent chromosomal copy number alterations in sporadic chordomas. PLoS One. 2011; 6(5):e18846. Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ, Iafrate AJ. PMID: 21602918.
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    124. Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines. Anticancer Res. 2011 Apr; 31(4):1115-23. Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z. PMID: 21508354.
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    125. ROCK1 as a potential therapeutic target in osteosarcoma. J Orthop Res. 2011 Aug; 29(8):1259-66. Liu X, Choy E, Hornicek FJ, Yang S, Yang C, Harmon D, Mankin H, Duan Z. PMID: 21387396.
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    127. Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. Mol Cancer Ther. 2010 Dec; 9(12):3342-50. Susa M, Choy E, Liu X, Schwab J, Hornicek FJ, Mankin H, Duan Z. PMID: 20881269.
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    128. Blockage of Stat3 with CDDO-Me inhibits tumor cell growth in chordoma. Spine (Phila Pa 1976). 2010 Aug 15; 35(18):1668-75. Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Mankin H, Duan Z. PMID: 20386502.
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    129. Effects of siltuximab on the IL-6-induced signaling pathway in ovarian cancer. Clin Cancer Res. 2010 Dec 01; 16(23):5759-69. Guo Y, Nemeth J, O'Brien C, Susa M, Liu X, Zhang Z, Choy E, Mankin H, Hornicek F, Duan Z. PMID: 20699329.
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    133. Nanoparticles: a promising modality in the treatment of sarcomas. Pharm Res. 2011 Feb; 28(2):260-72. Susa M, Milane L, Amiji MM, Hornicek FJ, Duan Z. PMID: 20505985.
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    136. Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. BMC Cancer. 2010 May 10; 10:187. Ryu K, Susa M, Choy E, Yang C, Hornicek FJ, Mankin HJ, Duan Z. PMID: 20459702.
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    137. Multidrug resistance reversal agent, NSC77037, identified with a cell-based screening assay. J Biomol Screen. 2010 Mar; 15(3):287-96. Susa M, Choy E, Yang C, Schwab J, Mankin H, Hornicek F, Duan Z. PMID: 20150589.
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    138. Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. Cancer Lett. 2010 Jul 28; 293(2):220-9. Duan Z, Ji D, Weinstein EJ, Liu X, Susa M, Choy E, Yang C, Mankin H, Hornicek FJ. PMID: 20144850.
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    139. Augmentation of therapeutic efficacy in drug-resistant tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems. AAPS J. 2010 Jun; 12(2):171-80. van Vlerken LE, Duan Z, Little SR, Seiden MV, Amiji MM. PMID: 20143195.
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    150. Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer. Mol Cancer Ther. 2008 Aug; 7(8):2377-85. Duan Z, Weinstein EJ, Ji D, Ames RY, Choy E, Mankin H, Hornicek FJ. PMID: 18687998.
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    151. CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. Cancer Chemother Pharmacol. 2009 Mar; 63(4):681-9. Duan Z, Ames RY, Ryan M, Hornicek FJ, Mankin H, Seiden MV. PMID: 18587580.
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    152. Modulation of drug resistance in ovarian adenocarcinoma by enhancing intracellular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticles. Clin Cancer Res. 2008 May 15; 14(10):3193-203. Devalapally H, Duan Z, Seiden MV, Amiji MM. PMID: 18483388.
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    153. Paclitaxel and ceramide co-administration in biodegradable polymeric nanoparticulate delivery system to overcome drug resistance in ovarian cancer. Int J Cancer. 2007 Oct 15; 121(8):1830-8. Devalapally H, Duan Z, Seiden MV, Amiji MM. PMID: 17557285.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    154. 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells. Mol Pharmacol. 2007 Nov; 72(5):1137-45. Duan Z, Bradner J, Greenberg E, Mazitschek R, Foster R, Mahoney J, Seiden MV. PMID: 17675586.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    155. Modulation of intracellular ceramide using polymeric nanoparticles to overcome multidrug resistance in cancer. Cancer Res. 2007 May 15; 67(10):4843-50. van Vlerken LE, Duan Z, Seiden MV, Amiji MM. PMID: 17510414.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    156. Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer. Clin Cancer Res. 2006 Sep 01; 12(17):5055-63. Duan Z, Foster R, Bell DA, Mahoney J, Wolak K, Vaidya A, Hampel C, Lee H, Seiden MV. PMID: 16951221.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    157. Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal of paclitaxel resistance in human ovarian cancer cells. Mol Cancer Ther. 2004 Jul; 3(7):833-8. Duan Z, Brakora KA, Seiden MV. PMID: 15252144.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
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