Andrea J Rapkin

Title(s)Professor, Obstetrics and Gynecology
Address760 Westwood Plaza 27-126
Los Angeles CA 90024
PhoneApt 47274, Adm 56963
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    Deriving Novel Biomarkers of Localized Provoked Vulvodynia through Metabolomics: A Biological System Based Approach
    NIH/NICHD R21HD086737Aug 1, 2016 - Jul 31, 2018
    Role: Co-Principal Investigator
    NIH/NICHD R01HD076756Sep 1, 2013 - May 31, 2018
    Role: Co-Principal Investigator
    Neural Substrates of Emotion Regulation in Premenstrual Dysphoric Disorder
    NIH/NIMH R21MH098668May 1, 2013 - Apr 30, 2015
    Role: Co-Principal Investigator

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    1. Predictors of Mucosal and Muscle Pain in Vulvodynia: A Cross-Sectional Analysis From the National Vulvodynia Registry. J Pain. 2020 Jul 14. Lo L, Lamvu G, Alappattu M, Witzeman K, Markovic D, Rapkin A. PMID: 32679255.
      View in: PubMed   Mentions:    Fields:    
    2. Effectiveness of transdermal nicotine patch in premenopausal female smokers is moderated by within-subject severity of negative affect and physical symptoms. Psychopharmacology (Berl). 2020 Jun; 237(6):1737-1744. Chai SH, Leventhal AM, Kirkpatrick MG, Eisenlohr-Moul TA, Rapkin AJ, D'Orazio L, Pang RD. PMID: 32157328.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Resting-state functional connectivity in women with PMDD. Transl Psychiatry. 2019 12 11; 9(1):339. Petersen N, Ghahremani DG, Rapkin AJ, Berman SM, Wijker N, Liang L, London ED. PMID: 31827073.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. Contraception counseling for women with premenstrual dysphoric disorder (PMDD): current perspectives. Open Access J Contracept. 2019; 10:27-39. Rapkin AJ, Korotkaya Y, Taylor KC. PMID: 31572029.
      View in: PubMed   Mentions:
    5. Altered gray matter volume in sensorimotor and thalamic regions associated with pain in localized provoked vulvodynia: a voxel-based morphometry study. Pain. 2019 07; 160(7):1529-1540. Bhatt RR, Gupta A, Rapkin A, Kilpatrick LA, Hamadani K, Pazmany E, Van Oudenhove L, Stains J, Aerts L, Enzlin P, Tillisch K, Mayer EA, Labus JS. PMID: 30817440.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Experimental evaluation of central pain processes in young women with primary dysmenorrhea. Pain. 2019 06; 160(6):1421-1430. Payne LA, Seidman LC, Sim MS, Rapkin AJ, Naliboff BD, Zeltzer LK. PMID: 30720583.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Disease-Related Microstructural Differences in the Brain in Women With Provoked Vestibulodynia. J Pain. 2018 05; 19(5):528.e1-528.e15. Gupta A, Woodworth DC, Ellingson BM, Rapkin AJ, Naliboff B, Kilpatrick LA, Stains J, Masghati S, Tillisch K, Mayer EA, Labus JS. PMID: 29391213.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Brain activation during emotion regulation in women with premenstrual dysphoric disorder. Psychol Med. 2018 08; 48(11):1795-1802. Petersen N, Ghahremani DG, Rapkin AJ, Berman SM, Liang L, London ED. PMID: 29145910.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Rates of Anovulation in Adolescents and Young Adults with Moderate to Severe Primary Dysmenorrhea and Those without Primary Dysmenorrhea. J Pediatr Adolesc Gynecol. 2018 Apr; 31(2):94-101. Seidman LC, Brennan KM, Rapkin AJ, Payne LA. PMID: 29017868.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Experimental and procedural pain responses in primary dysmenorrhea: a systematic review. J Pain Res. 2017; 10:2233-2246. Payne LA, Rapkin AJ, Seidman LC, Zeltzer LK, Tsao JC. PMID: 29066929.
      View in: PubMed   Mentions:
    11. Catechol-O-methyltransferase gene polymorphism and vulvar pain in women with vulvodynia. Am J Obstet Gynecol. 2017 Apr; 216(4):395.e1-395.e6. Patanwala IY, Lamvu G, Ledger WJ, Witzeman K, Marvel R, Rapkin A, Bongiovanni AM, Feranec J, Witkin SS. PMID: 27780702.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Fourth consensus of the International Society for Premenstrual Disorders (ISPMD): auditable standards for diagnosis and management of premenstrual disorder. Arch Womens Ment Health. 2016 12; 19(6):953-958. Ismaili E, Walsh S, O'Brien PMS, Bäckström T, Brown C, Dennerstein L, Eriksson E, Freeman EW, Ismail KMK, Panay N, Pearlstein T, Rapkin A, Steiner M, Studd J, Sundström-Paromma I, Endicott J, Epperson CN, Halbreich U, Reid R, Rubinow D, Schmidt P, Yonkers K. PMID: 27378473.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    13. Emotion regulation in women with premenstrual dysphoric disorder. Arch Womens Ment Health. 2016 10; 19(5):891-8. Petersen N, London ED, Liang L, Ghahremani DG, Gerards R, Goldman L, Rapkin AJ. PMID: 27155663.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Pain Catastrophizing Predicts Menstrual Pain Ratings in Adolescent Girls with Chronic Pain. Pain Med. 2016 Jan; 17(1):16-24. Payne LA, Rapkin AJ, Lung KC, Seidman LC, Zeltzer LK, Tsao JC. PMID: 26218344.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Vulvodynia: The Role of Inflammation in the Etiology of Localized Provoked Pain of the Vulvar Vestibule (Vestibulodynia). Semin Reprod Med. 2015 Jul; 33(4):239-45. Akopians AL, Rapkin AJ. PMID: 26132928.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. The Evidence-based Vulvodynia Assessment Project. A National Registry for the Study of Vulvodynia. J Reprod Med. 2015 May-Jun; 60(5-6):223-35. Lamvu G, Nguyen RH, Burrows LJ, Rapkin A, Witzeman K, Marvel RP, Hutchins D, Witkin SS, Veasley C, Fillingim R, Zolnoun D. PMID: 26126308.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Disease-related differences in resting-state networks: a comparison between localized provoked vulvodynia, irritable bowel syndrome, and healthy control subjects. Pain. 2015 May; 156(5):809-19. Gupta A, Rapkin AJ, Gill Z, Kilpatrick L, Fling C, Stains J, Masghati S, Tillisch K, Mayer EA, Labus JS. PMID: 25735001.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    18. The Cerebellum and Premenstrual Dysphoric Disorder. AIMS Neurosci. 2014; 1(2):120-141. Rapkin AJ, Berman SM, London ED. PMID: 28275721.
      View in: PubMed   Mentions:
    19. Treatment of premenstrual dysphoric disorder. Womens Health (Lond). 2013 Nov; 9(6):537-56. Rapkin AJ, Lewis EI. PMID: 24161307.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    20. Premenstrual dysphoric disorder and severe premenstrual syndrome in adolescents. Paediatr Drugs. 2013 Jun; 15(3):191-202. Rapkin AJ, Mikacich JA. PMID: 23529867.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    21. Clinical subtypes of core premenstrual disorders: a Delphi survey. Arch Womens Ment Health. 2013 Jun; 16(3):197-201. Ismail KM, Nevatte T, O'Brien S, Paschetta E, Bäckström T, Dennerstein L, Eriksson E, Freeman EW, Panay N, Pearlstein T, Rapkin A, Steiner M, Studd J, Sundström-Poromaa I. PMID: 23292120.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Multilevel local anesthetic nerve blockade for the treatment of generalized vulvodynia: a pilot study. J Sex Med. 2012 Nov; 9(11):2919-26. McDonald JS, Rapkin AJ. PMID: 22925528.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Elevated gray matter volume of the emotional cerebellum in women with premenstrual dysphoric disorder. J Affect Disord. 2013 Apr 05; 146(2):266-71. Berman SM, London ED, Morgan M, Rapkin AJ. PMID: 22868063.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Pathophysiology of premenstrual syndrome and premenstrual dysphoric disorder. Menopause Int. 2012 Jun; 18(2):52-9. Rapkin AJ, Akopians AL. PMID: 22611222.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    25. An overview of four studies of a continuous oral contraceptive (levonorgestrel 90 mcg/ethinyl estradiol 20 mcg) on premenstrual dysphoric disorder and premenstrual syndrome. Contraception. 2012 May; 85(5):437-45. Freeman EW, Halbreich U, Grubb GS, Rapkin AJ, Skouby SO, Smith L, Mirkin S, Constantine GD. PMID: 22152588.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    26. Estradiol attenuates the adenosine triphosphate-induced increase of intracellular calcium through group II metabotropic glutamate receptors in rat dorsal root ganglion neurons. J Neurosci Res. 2011 Nov; 89(11):1707-10. Chaban V, Li J, McDonald JS, Rapkin A, Micevych P. PMID: 21793040.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    27. Continuous oral levonorgestrel/ethinyl estradiol for treating premenstrual dysphoric disorder. Contraception. 2012 Jan; 85(1):19-27. Halbreich U, Freeman EW, Rapkin AJ, Cohen LS, Grubb GS, Bergeron R, Smith L, Mirkin S, Constantine GD. PMID: 22067793.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    28. Diagnosis and management of premenstrual disorders. BMJ. 2011 Jun 03; 342:d2994. O'Brien S, Rapkin A, Dennerstein L, Nevatte T. PMID: 21642323.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. Ethinyl estradiol 20µg/drospirenone 3mg 24/4 oral contraceptive for the treatment of functional impairment in women with premenstrual dysphoric disorder. Int J Gynaecol Obstet. 2011 May; 113(2):103-7. Marr J, Heinemann K, Kunz M, Rapkin A. PMID: 21338987.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Neuroimaging evidence of cerebellar involvement in premenstrual dysphoric disorder. Biol Psychiatry. 2011 Feb 15; 69(4):374-80. Rapkin AJ, Berman SM, Mandelkern MA, Silverman DH, Morgan M, London ED. PMID: 21092938.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    31. Clitoral and vulvar vestibular sensation in women taking 20 mcg ethinyl estradiol combined oral contraceptives: a preliminary study. J Sex Med. 2011 Jan; 8(1):213-8. Lee M, Morgan M, Rapkin A. PMID: 20955310.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Treatment of metronidazole-resistant Trichomonas vaginalis. Sex Health. 2009 Dec; 6(4):345-7. Goldman LM, Upcroft JA, Workowski K, Rapkin A. PMID: 19917205.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    33. Neuroactive steroids after estrogen exposure in depressed postmenopausal women treated with sertraline and asymptomatic postmenopausal women. Arch Womens Ment Health. 2010 Feb; 13(1):91-8. Morgan ML, Rapkin AJ, Biggio G, Serra M, Pisu MG, Rasgon N. PMID: 19728035.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Premenstrual syndrome and premenstrual dysphoric disorder: quality of life and burden of illness. Expert Rev Pharmacoecon Outcomes Res. 2009 Apr; 9(2):157-70. Rapkin AJ, Winer SA. PMID: 19402804.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansPHPublic Health
    35. Premenstrual syndrome and premenstrual dysphoric disorder in adolescents. Curr Opin Obstet Gynecol. 2008 Oct; 20(5):455-63. Rapkin AJ, Mikacich JA. PMID: 18797268.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. YAZ in the treatment of premenstrual dysphoric disorder. J Reprod Med. 2008 Sep; 53(9 Suppl):729-41. Rapkin AJ. PMID: 18980045.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. Inflammation in the uterus induces phosphorylated extracellular signal-regulated kinase and substance P immunoreactivity in dorsal root ganglia neurons innervating both uterus and colon in rats. J Neurosci Res. 2008 Sep; 86(12):2746-52. Li J, Micevych P, McDonald J, Rapkin A, Chaban V. PMID: 18478547.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    38. Drospirenone/ethinyl estradiol. Drugs Today (Barc). 2008 Feb; 44(2):133-45. Rapkin AJ, Sorger SN, Winer SA. PMID: 18389090.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. The pharmacologic management of premenstrual dysphoric disorder. Expert Opin Pharmacother. 2008 Feb; 9(3):429-45. Rapkin AJ, Winer SA. PMID: 18220493.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    40. Multilevel local anesthetic nerve blockade for the treatment of vulvar vestibulitis syndrome. Am J Obstet Gynecol. 2008 Jan; 198(1):41.e1-5. Rapkin AJ, McDonald JS, Morgan M. PMID: 17936236.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Ethinyl estradiol/drospirenone for the treatment of the emotional and physical symptoms of premenstrual dysphoric disorder. Womens Health (Lond). 2007 Jul; 3(4):395-408. Rapkin AJ, McDonald M, Winer SA. PMID: 19804014.
      View in: PubMed   Mentions: 1     Fields:    
    42. Drospirenone: a novel progestin. Expert Opin Pharmacother. 2007 May; 8(7):989-99. Rapkin AJ, Winer SA. PMID: 17472544.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    43. Clinical diagnostic criteria for premenstrual syndrome and guidelines for their quantification for research studies. Gynecol Endocrinol. 2007 Mar; 23(3):123-30. Halbreich U, Backstrom T, Eriksson E, O'brien S, Calil H, Ceskova E, Dennerstein L, Douki S, Freeman E, Genazzani A, Heuser I, Kadri N, Rapkin A, Steiner M, Wittchen HU, Yonkers K. PMID: 17454164.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    44. The same dorsal root ganglion neurons innervate uterus and colon in the rat. Neuroreport. 2007 Feb 12; 18(3):209-12. Chaban V, Christensen A, Wakamatsu M, McDonald M, Rapkin A, McDonald J, Micevych P. PMID: 17314658.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    45. Vasomotor symptoms in menopause: physiologic condition and central nervous system approaches to treatment. Am J Obstet Gynecol. 2007 Feb; 196(2):97-106. Rapkin AJ. PMID: 17306645.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    46. Oral contraceptives and neuroactive steroids. Pharmacol Biochem Behav. 2006 Aug; 84(4):628-34. Rapkin AJ, Biggio G, Concas A. PMID: 16854457.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    47. Neurophysiologic changes during estrogen augmentation in perimenopausal depression. Maturitas. 2007 Jan 20; 56(1):54-60. Morgan ML, Cook IA, Rapkin AJ, Leuchter AF. PMID: 16835012.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    48. Relationships among self-rated tanner staging, hormones, and psychosocial factors in healthy female adolescents. J Pediatr Adolesc Gynecol. 2006 Jun; 19(3):181-7. Rapkin AJ, Tsao JC, Turk N, Anderson M, Zeltzer LK. PMID: 16731411.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    49. Estrogen and response to sertraline in postmenopausal women with major depressive disorder: a pilot study. J Psychiatr Res. 2007 Apr-Jun; 41(3-4):338-43. Rasgon NL, Dunkin J, Fairbanks L, Altshuler LL, Troung C, Elman S, Wroolie TE, Brunhuber MV, Rapkin A. PMID: 16697413.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    50. Decreased neuroactive steroids induced by combined oral contraceptive pills are not associated with mood changes. Fertil Steril. 2006 May; 85(5):1371-8. Rapkin AJ, Morgan M, Sogliano C, Biggio G, Concas A. PMID: 16580672.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    51. Diagnosis of premenstrual disorders. J Reprod Med. 2006 Apr; 51(4 Suppl):349-58. Futterman LA, Rapkin AJ. PMID: 16734318.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    52. Premenstrual disorders: prevalence, etiology and impact. J Reprod Med. 2006 Apr; 51(4 Suppl):339-47. Winer SA, Rapkin AJ. PMID: 16734317.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    53. Treatment of premenstrual disorders. J Reprod Med. 2006 Apr; 51(4 Suppl):359-70. Kroll R, Rapkin AJ. PMID: 16734319.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    54. Premenstrual syndrome in adolescents: diagnosis and treatment. Pediatr Endocrinol Rev. 2006 Jan; 3 Suppl 1:132-7. Rapkin AJ, Mikacich JA. PMID: 16641847.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    55. New treatment approaches for premenstrual disorders. Am J Manag Care. 2005 Dec; 11(16 Suppl):S480-91. Rapkin AJ. PMID: 16336057.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    56. Efficacy of a new low-dose oral contraceptive with drospirenone in premenstrual dysphoric disorder. Obstet Gynecol. 2005 Sep; 106(3):492-501. Yonkers KA, Brown C, Pearlstein TB, Foegh M, Sampson-Landers C, Rapkin A. PMID: 16135578.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCTClinical Trials
    57. Estrogen augmentation of antidepressants in perimenopausal depression: a pilot study. J Clin Psychiatry. 2005 Jun; 66(6):774-80. Morgan ML, Cook IA, Rapkin AJ, Leuchter AF. PMID: 15960574.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    58. Reproductive events modify the effects of estrogen replacement therapy on cognition in healthy postmenopausal women. Psychoneuroendocrinology. 2005 Apr; 30(3):284-96. Dunkin J, Rasgon N, Wagner-Steh K, David S, Altshuler L, Rapkin A. PMID: 15511602.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    59. Gynecological health of females with congenital heart disease. Int J Cardiol. 2005 Feb 28; 98(3):379-87. Canobbio MM, Perloff JK, Rapkin AJ. PMID: 15708168.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    60. A review of treatment of premenstrual syndrome and premenstrual dysphoric disorder. Psychoneuroendocrinology. 2003 Aug; 28 Suppl 3:39-53. Rapkin A. PMID: 12892989.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    61. Effect of an oral contraceptive containing ethinyl estradiol and drospirenone on premenstrual symptomatology and health-related quality of life. J Reprod Med. 2003 Feb; 48(2):79-85. Borenstein J, Yu HT, Wade S, Chiou CF, Rapkin A. PMID: 12621790.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    62. The clinical nature and formal diagnosis of premenstrual, postpartum, and perimenopausal affective disorders. Curr Psychiatry Rep. 2002 Dec; 4(6):419-28. Rapkin AJ, Mikacich JA, Moatakef-Imani B, Rasgon N. PMID: 12441021.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    63. Cognitive flexibility, reaction time, and attention in women with premenstrual dysphoric disorder. J Gend Specif Med. 2002 May-Jun; 5(3):28-36. Morgan M, Rapkin A. PMID: 12078060.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    64. Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal women. J Clin Psychiatry. 2002; 63 Suppl 7:45-8. Rasgon NL, Altshuler LL, Fairbanks LA, Dunkin JJ, Davtyan C, Elman S, Rapkin AJ. PMID: 11995778.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCTClinical Trials
    65. Peritoneal fluid interleukin-6 in women with chronic pelvic pain. Fertil Steril. 2000 Aug; 74(2):325-8. Rapkin A, Morgan M, Bonpane C, Martinez-Maza O. PMID: 10927052.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
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