Antonio La Cava

Title(s)Professor-in-Residence, Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Autoantibody blockade in neonatal lupus
    NIH R21AI154935May 22, 2020 - Apr 30, 2022
    Role: Principal Investigator
    Antibody-mediated suppression of autoimmunity in humanized mice
    NIH R21HD097531Mar 17, 2019 - Feb 28, 2021
    Role: Principal Investigator
    Leptin and mTOR: metabolic partners in autoimmunity
    NIH R21AI109677Jul 1, 2015 - Jun 30, 2018
    Role: Principal Investigator
    Sexual Dimorphism and Dysregulated Immune Responses in SLE: The Role of Leptin
    NIH R21AI095921Aug 18, 2011 - Jul 31, 2013
    Role: Principal Investigator
    Role of Leptin in Systemic Lupus Erythematosus
    NIH R01AR053239Aug 1, 2006 - Jun 30, 2012
    Role: Principal Investigator
    Leptin-based intervention in systemic autoimmunity
    NIH R21AI063515Apr 1, 2005 - Mar 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Strategies to Use Nanoparticles to Generate CD4 and CD8 Regulatory T Cells for the Treatment of SLE and Other Autoimmune Diseases. Front Immunol. 2021; 12:681062. Horwitz DA, Bickerton S, La Cava A. PMID: 34211471.
      View in: PubMed   Mentions:    Fields:    
    2. Nanoparticles Engineered as Artificial Antigen-Presenting Cells Induce Human CD4+ and CD8+ Tregs That Are Functional in Humanized Mice. Front Immunol. 2021; 12:628059. Giang S, Horwitz DA, Bickerton S, La Cava A. PMID: 34122401.
      View in: PubMed   Mentions: 1     Fields:    
    3. The pleiotropic roles of leptin in metabolism, immunity, and cancer. J Exp Med. 2021 May 03; 218(5). de Candia P, Prattichizzo F, Garavelli S, Alviggi C, La Cava A, Matarese G. PMID: 33857282.
      View in: PubMed   Mentions:    Fields:    
    4. Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-ß-Dependent Mechanism. Front Immunol. 2020; 11:583338. Horwitz DA, Liu A, Bickerton S, Castaldo G, Matarese G, Fahmy TM, La Cava A. PMID: 33391260.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Editorial overview: Research progress in autoimmunity: an overview and update. Curr Opin Immunol. 2020 12; 67:iii-v. La Cava A. PMID: 33323175.
      View in: PubMed   Mentions:    Fields:    
    6. DNA vaccine encoding heat shock protein 90 protects from murine lupus. Arthritis Res Ther. 2020 06 22; 22(1):152. Liu A, Shi FD, Cohen IR, Castaldo G, Matarese G, Quintana FJ, La Cava A. PMID: 32571400.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. DNA Vaccination With Hsp70 Protects Against Systemic Lupus Erythematosus in (NZB × NZW)F1 Mice. Arthritis Rheumatol. 2020 06; 72(6):997-1002. Liu A, Ferretti C, Shi FD, Cohen IR, Quintana FJ, La Cava A. PMID: 31943822.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    8. Serafino Zappacosta: An Enlightened Mentor and Educator. Front Immunol. 2020; 11:217. Carbone E, De Felice M, Di Rosa F, D'Oro U, Fontana S, La Cava A, Maio M, Matarese G, Racioppi L, Ruggiero G, Terrazzano G. PMID: 32117323.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Rebalancing Immune Homeostasis to Treat Autoimmune Diseases. Trends Immunol. 2019 10; 40(10):888-908. Horwitz DA, Fahmy TM, Piccirillo CA, La Cava A. PMID: 31601519.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    10. The Influence of Diet and Obesity on Gene Expression in SLE. Genes (Basel). 2019 05 27; 10(5). La Cava A. PMID: 31137916.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Suppression of Murine Lupus by CD4+ and CD8+ Treg Cells Induced by T Cell-Targeted Nanoparticles Loaded With Interleukin-2 and Transforming Growth Factor ß. Arthritis Rheumatol. 2019 04; 71(4):632-640. Horwitz DA, Bickerton S, Koss M, Fahmy TM, La Cava A. PMID: 30407752.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    12. Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury. Stroke. 2018 Jun; 49(6):1471-1478. Jin WN, Gonzales R, Feng Y, Wood K, Chai Z, Dong JF, La Cava A, Shi FD, Liu Q. PMID: 29695462.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    13. Tregs in SLE: an Update. Curr Rheumatol Rep. 2018 02 21; 20(2):6. La Cava A. PMID: 29464438.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. Metabolic pressure and the breach of immunological self-tolerance. Nat Immunol. 2017 Oct 18; 18(11):1190-1196. De Rosa V, La Cava A, Matarese G. PMID: 29044230.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    15. Leptin in inflammation and autoimmunity. Cytokine. 2017 10; 98:51-58. La Cava A. PMID: 27916613.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    16. Organ- and cell-specific immune responses are associated with the outcomes of intracerebral hemorrhage. FASEB J. 2018 01; 32(1):220-229. Zhang J, Shi K, Li Z, Li M, Han Y, Wang L, Zhang Z, Yu C, Zhang F, Song L, Dong JF, La Cava A, Sheth KN, Shi FD. PMID: 28877956.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. IRF1 and BATF: key drivers of type 1 regulatory T-cell differentiation. Cell Mol Immunol. 2017 Aug; 14(8):652-654. Giang S, La Cava A. PMID: 28626238.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    18. Brain Ischemia Suppresses Immunity in the Periphery and Brain via Different Neurogenic Innervations. Immunity. 2017 03 21; 46(3):474-487. Liu Q, Jin WN, Liu Y, Shi K, Sun H, Zhang F, Zhang C, Gonzales RJ, Sheth KN, La Cava A, Shi FD. PMID: 28314594.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    19. Regulatory T Cells in SLE: Biology and Use in Treatment. Curr Rheumatol Rep. 2016 11; 18(11):67. Giang S, La Cava A. PMID: 27704250.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    20. Role of Metabolism in the Immunobiology of Regulatory T Cells. J Immunol. 2016 10 01; 197(7):2567-75. Galgani M, De Rosa V, La Cava A, Matarese G. PMID: 27638939.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    21. Leptin promotes systemic lupus erythematosus by increasing autoantibody production and inhibiting immune regulation. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):10637-42. Lourenço EV, Liu A, Matarese G, La Cava A. PMID: 27588900.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    22. Editorial: Survive to Fight: Effector Treg Cells in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2016 06; 68(6):1327-9. La Cava A. PMID: 26866416.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements. Immunity. 2016 03 15; 44(3):712. Procaccini C, Carbone F, Di Silvestre D, Brambilla F, De Rosa V, Galgani M, Faicchia D, Marone G, Tramontano D, Corona M, Alviggi C, Porcellini A, La Cava A, Mauri P, Matarese G. PMID: 28843073.
      View in: PubMed   Mentions: 17     Fields:    
    24. The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements. Immunity. 2016 Feb 16; 44(2):406-21. Procaccini C, Carbone F, Di Silvestre D, Brambilla F, De Rosa V, Galgani M, Faicchia D, Marone G, Tramontano D, Corona M, Alviggi C, Porcellini A, La Cava A, Mauri P, Matarese G. PMID: 26885861; PMCID: PMC4760097.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    25. Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Nat Neurosci. 2016 Feb; 19(2):243-52. Liu Q, Sanai N, Jin WN, La Cava A, Van Kaer L, Shi FD. PMID: 26752157.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    26. Adaptive immune regulation in autoimmune diabetes. Autoimmun Rev. 2016 Mar; 15(3):236-41. Ferretti C, La Cava A. PMID: 26631820.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    27. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants. Nat Immunol. 2015 Nov; 16(11):1174-84. De Rosa V, Galgani M, Porcellini A, Colamatteo A, Santopaolo M, Zuchegna C, Romano A, De Simone S, Procaccini C, La Rocca C, Carrieri PB, Maniscalco GT, Salvetti M, Buscarinu MC, Franzese A, Mozzillo E, La Cava A, Matarese G. PMID: 26414764; PMCID: PMC4868085.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    28. Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. Clin Immunol. 2015 Dec; 161(2):157-62. Zhao J, Wu H, Langefeld CD, Kaufman KM, Kelly JA, Bae SC, Marta E. Alarcón-Riquelme for the BIOLUPUS and GENLES networks , Alarcón GS, Anaya JM, Criswell LA, Freedman BI, Kamen DL, Gilkeson GS, Jacob CO, James JA, Merrill JT, Gaffney PM, Sivils KM, Niewold TB, Petri MA, Song ST, Jeong HJ, Ramsey-Goldman R, Reveille JD, Scofield RH, Stevens AM, Boackle SA, Vilá LM, Chang DM, Song YW, Vyse TJ, Harley JB, Brown EE, Edberg JC, Kimberly RP, Hahn BH, Grossman JM, Tsao BP, La Cava A. PMID: 26385092.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Leptin enhances availability of apoptotic cell-derived self-antigen in systemic lupus erythematosus. PLoS One. 2014; 9(11):e112826. Amarilyo G, Iikuni N, Liu A, Matarese G, La Cava A. PMID: 25401752; PMCID: PMC4234630.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    30. IL-17 promotes murine lupus. J Immunol. 2014 Jul 15; 193(2):540-3. Amarilyo G, Lourenço EV, Shi FD, La Cava A. PMID: 24920843.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    31. Regulatory CD4+ T cells promote B cell anergy in murine lupus. J Immunol. 2014 May 01; 192(9):4069-73. Liu Y, Liu A, Iikuni N, Xu H, Shi FD, La Cava A. PMID: 24670801.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    32. Ischemic neurons recruit natural killer cells that accelerate brain infarction. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2704-9. Gan Y, Liu Q, Wu W, Yin JX, Bai XF, Shen R, Wang Y, Chen J, La Cava A, Poursine-Laurent J, Yokoyama W, Shi FD. PMID: 24550298; PMCID: PMC3932858.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    33. Regulatory T cell proliferative potential is impaired in human autoimmune disease. Nat Med. 2014 Jan; 20(1):69-74. Carbone F, De Rosa V, Carrieri PB, Montella S, Bruzzese D, Porcellini A, Procaccini C, La Cava A, Matarese G. PMID: 24317118.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    34. Epigenetic dysregulation in systemic lupus erythematosus. Autoimmunity. 2014 Jun; 47(4):215-9. Liu A, La Cava A. PMID: 24128164.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    35. Leptin promotes lupus T-cell autoimmunity. Clin Immunol. 2013 Dec; 149(3):530-3. Amarilyo G, Iikuni N, Shi FD, Liu A, Matarese G, La Cava A. PMID: 24263282.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    36. Blockade of programmed death-1 in young (New Zealand Black x New Zealand White)F1 mice promotes the suppressive capacity of CD4+ regulatory T cells protecting from lupus-like disease. J Immunol. 2013 Jun 01; 190(11):5402-10. Wong M, La Cava A, Hahn BH. PMID: 23636058.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    37. Cutting edge: Leptin-induced ROR?t expression in CD4+ T cells promotes Th17 responses in systemic lupus erythematosus. J Immunol. 2013 Apr 01; 190(7):3054-8. Yu Y, Liu Y, Shi FD, Zou H, Matarese G, La Cava A. PMID: 23447682; PMCID: PMC3608794.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    38. Meta-immunological profiling of children with type 1 diabetes identifies new biomarkers to monitor disease progression. Diabetes. 2013 Jul; 62(7):2481-91. Galgani M, Nugnes R, Bruzzese D, Perna F, De Rosa V, Procaccini C, Mozzillo E, Cilio CM, Elding Larsson H, Lernmark A, La Cava A, Franzese A, Matarese G. PMID: 23396400.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    39. Targeting the BLyS-APRIL signaling pathway in SLE. Clin Immunol. 2013 Sep; 148(3):322-7. La Cava A. PMID: 23269199.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    40. Tocilizumab attenuates inflammation in ALS patients through inhibition of IL6 receptor signaling. Am J Neurodegener Dis. 2012; 1(3):305-15. Mizwicki MT, Fiala M, Magpantay L, Aziz N, Sayre J, Liu G, Siani A, Chan D, Martinez-Maza O, Chattopadhyay M, La Cava A. PMID: 23383400.
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    41. Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses. J Immunol. 2012 Sep 15; 189(6):2941-53. Procaccini C, De Rosa V, Galgani M, Carbone F, Cassano S, Greco D, Qian K, Auvinen P, Calì G, Stallone G, Formisano L, La Cava A, Matarese G. PMID: 22904304.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    42. Proinflammatory activities of leptin in non-autoimmune conditions. Inflamm Allergy Drug Targets. 2012 Aug 01; 11(4):298-302. La Cava A. PMID: 22458591.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    43. Adiponectin: a relevant player in obesity-related colorectal cancer? Gut. 2013 Apr; 62(4):483-4. La Cava A. PMID: 22851665.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    44. In vivo veritas, in vitro artificia. Trends Mol Med. 2012 Aug; 18(8):439-42. Matarese G, La Cava A, Horvath TL. PMID: 22682514; PMCID: PMC3477516.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    45. miRNA in systemic lupus erythematosus. Clin Immunol. 2012 Jul; 144(1):26-31. Amarilyo G, La Cava A. PMID: 22659032.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    46. Targeting BLyS in systemic lupus erythematosus. Recent Pat Inflamm Allergy Drug Discov. 2012 May; 6(2):91-6. Liu Y, La Cava A. PMID: 22216778.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    47. Cutting edge: fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus. J Immunol. 2012 Mar 01; 188(5):2070-3. Liu Y, Yu Y, Matarese G, La Cava A. PMID: 22291185; PMCID: PMC3288569.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    48. Preclinical studies with synthetic peptides in systemic lupus erythematosus. Front Biosci (Landmark Ed). 2012 Jan 01; 17:1940-7. Amarilyo G, Hahn B, La Cava A. PMID: 22201847.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    49. Neuronal phagocytosis by inflammatory macrophages in ALS spinal cord: inhibition of inflammation by resolvin D1. Am J Neurodegener Dis. 2012; 1(1):60-74. Liu G, Fiala M, Mizwicki MT, Sayre J, Magpantay L, Siani A, Mahanian M, Chattopadhyay M, La Cava A, Wiedau-Pazos M. PMID: 22787561.
      View in: PubMed   Mentions:
    50. Tolerance induced by anti-DNA Ig peptide in (NZB×NZW)F1 lupus mice impinges on the resistance of effector T cells to suppression by regulatory T cells. Clin Immunol. 2012 Mar; 142(3):291-5. Yu Y, Liu Y, Shi FD, Zou H, Hahn BH, La Cava A. PMID: 22137928.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    51. Organ-specific features of natural killer cells. Nat Rev Immunol. 2011 Sep 23; 11(10):658-71. Shi FD, Ljunggren HG, La Cava A, Van Kaer L. PMID: 21941294; PMCID: PMC3620656.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    52. High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Ann Rheum Dis. 2011 Sep; 70(9):1619-24. McMahon M, Skaggs BJ, Sahakian L, Grossman J, FitzGerald J, Ragavendra N, Charles-Schoeman C, Chernishof M, Gorn A, Witztum JL, Wong WK, Weisman M, Wallace DJ, La Cava A, Hahn BH. PMID: 21670088.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    53. Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation. Ann Neurol. 2011 Apr; 69(4):721-34. Hao J, Campagnolo D, Liu R, Piao W, Shi S, Hu B, Xiang R, Zhou Q, Vollmer T, Van Kaer L, La Cava A, Shi FD. PMID: 21425186; PMCID: PMC3082615.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    54. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity. 2010 Dec 14; 33(6):929-41. Procaccini C, De Rosa V, Galgani M, Abanni L, Calì G, Porcellini A, Carbone F, Fontana S, Horvath TL, La Cava A, Matarese G. PMID: 21145759; PMCID: PMC3133602.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    55. Natural regulatory T cells in autoimmunity. Autoimmunity. 2011 Feb; 44(1):33-42. Lourenço EV, La Cava A. PMID: 21091291; PMCID: PMC3057884.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    56. Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway. J Immunol. 2010 Dec 15; 185(12):7474-9. Galgani M, Procaccini C, De Rosa V, Carbone F, Chieffi P, La Cava A, Matarese G. PMID: 21078910.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    57. IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients. J Neuroinflammation. 2010 Nov 09; 7:76. Fiala M, Chattopadhay M, La Cava A, Tse E, Liu G, Lourenco E, Eskin A, Liu PT, Magpantay L, Tse S, Mahanian M, Weitzman R, Tong J, Nguyen C, Cho T, Koo P, Sayre J, Martinez-Maza O, Rosenthal MJ, Wiedau-Pazos M. PMID: 21062492.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    58. Blockade of programmed death-1 in young (New Zealand black x New Zealand white)F1 mice promotes the activity of suppressive CD8+ T cells that protect from lupus-like disease. J Immunol. 2010 Dec 01; 185(11):6563-71. Wong M, La Cava A, Singh RP, Hahn BH. PMID: 21041733.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    59. Targeting B cells with biologics in systemic lupus erythematosus. Expert Opin Biol Ther. 2010 Nov; 10(11):1555-61. La Cava A. PMID: 20919800.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    60. Modulation of autoimmunity with artificial peptides. Autoimmun Rev. 2010 Nov; 10(1):18-21. La Cava A. PMID: 20807590.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    61. Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology. J Exp Med. 2010 Aug 30; 207(9):1907-21. Hao J, Liu R, Piao W, Zhou Q, Vollmer TL, Campagnolo DI, Xiang R, La Cava A, Van Kaer L, Shi FD. PMID: 20696699; PMCID: PMC2931174.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    62. Regulatory immune cell subsets in autoimmunity. Autoimmunity. 2011 Feb; 44(1):1-2. La Cava A. PMID: 20670121.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    63. Leptin as a metabolic link to multiple sclerosis. Nat Rev Neurol. 2010 Aug; 6(8):455-61. Matarese G, Carrieri PB, Montella S, De Rosa V, La Cava A. PMID: 20606678.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    64. Anticytokine therapies in systemic lupus erythematosus. Immunotherapy. 2010 Jul; 2(4):575-82. La Cava A. PMID: 20636010.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    65. Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia. Eur J Immunol. 2010 Jun; 40(6):1577-89. Liu R, Zhou Q, La Cava A, Campagnolo DI, Van Kaer L, Shi FD. PMID: 20352624; PMCID: PMC3600978.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    66. Regulatory T cells in obesity: the leptin connection. Trends Mol Med. 2010 Jun; 16(6):247-56. Matarese G, Procaccini C, De Rosa V, Horvath TL, La Cava A. PMID: 20493774.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    67. Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis. Arthritis Res Ther. 2010; 12(3):R93. Woo JM, Lin Z, Navab M, Van Dyck C, Trejo-Lopez Y, Woo KM, Li H, Castellani LW, Wang X, Iikuni N, Rullo OJ, Wu H, La Cava A, Fogelman AM, Lusis AJ, Tsao BP. PMID: 20482780.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    68. CD8+ Tregs in lupus, autoimmunity, and beyond. Autoimmun Rev. 2010 Jun; 9(8):560-8. Dinesh RK, Skaggs BJ, La Cava A, Hahn BH, Singh RP. PMID: 20385256.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    69. Leptin in non-autoimmune inflammation. Inflamm Allergy Drug Targets. 2009 Sep; 8(4):285-91. Cai C, Hahn BH, Matarese G, La Cava A. PMID: 19754412.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    70. Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosus. J Immunol. 2009 Aug 01; 183(3):1518-22. Iikuni N, Lourenço EV, Hahn BH, La Cava A. PMID: 19570829.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    71. Modulation of p38 MAPK activity in regulatory T cells after tolerance with anti-DNA Ig peptide in (NZB x NZW)F1 lupus mice. J Immunol. 2009 Jun 15; 182(12):7415-21. Lourenço EV, Procaccini C, Ferrera F, Iikuni N, Singh RP, Filaci G, Matarese G, Shi FD, Brahn E, Hahn BH, La Cava A. PMID: 19494264.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    72. Antibody-based therapies in systemic lupus erythematosus. Mini Rev Med Chem. 2009 Jun; 9(7):829-46. Iikuni N, La Cava A. PMID: 19519508.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    73. The busy life of regulatory T cells in systemic lupus erythematosus. Discov Med. 2009 Jun; 8(40):13-7. La Cava A. PMID: 19772836.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    74. Mimicking self-antigens with synthetic peptides in systemic autoimmune rheumatic diseases. Curr Clin Pharmacol. 2009 May; 4(2):142-7. Cai C, La Cava A. PMID: 19442079.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    75. Cytokines in systemic lupus erythematosus. Curr Mol Med. 2009 Apr; 9(3):242-54. Lourenço EV, La Cava A. PMID: 19355907; PMCID: PMC3589140.
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    76. Lupus and T cells. Lupus. 2009 Mar; 18(3):196-201. La Cava A. PMID: 19213856.
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    77. Potential for anti-DNA immunoglobulin peptide therapy in systemic lupus erythematosus. Expert Opin Biol Ther. 2009 Feb; 9(2):201-6. Iikuni N, Hahn BH, La Cava A. PMID: 19236250.
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    78. Leptin signaling: A key pathway in immune responses. Curr Signal Transduct Ther. 2009 Jan 01; 4(1):22-30. Procaccini C, Lourenco EV, Matarese G, La Cava A. PMID: 19774101.
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    79. Natural Tregs and autoimmunity. Front Biosci (Landmark Ed). 2009 Jan 01; 14:333-43. La Cava A. PMID: 19273070.
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    80. Immunotherapy with peptides in systemic lupus erythematosus. Curr Med Chem. 2009; 16(12):1482-8. La Cava A. PMID: 19355901.
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    81. Tuning immune suppression in systemic autoimmunity with self-derived peptides. Inflamm Allergy Drug Targets. 2008 Dec; 7(4):253-9. Singh RP, Hahn BH, La Cava A. PMID: 19075790.
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    82. Tregs are regulated by cytokines: implications for autoimmunity. Autoimmun Rev. 2008 Oct; 8(1):83-7. La Cava A. PMID: 18771756.
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    83. Anti-DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients. Arthritis Rheum. 2008 Aug; 58(8):2488-97. Hahn BH, Anderson M, Le E, La Cava A. PMID: 18668553.
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    84. Cutaneous vasculitis in breast cancer treated with chemotherapy. Clin Immunol. 2008 Oct; 129(1):3-9. Wong M, Grossman J, Hahn BH, La Cava A. PMID: 18640073.
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    85. CCL2 recruitment of IL-6-producing CD11b+ monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity. Eur J Immunol. 2008 Jul; 38(7):1877-88. Bai Y, Liu R, Huang D, La Cava A, Tang YY, Iwakura Y, Campagnolo DI, Vollmer TL, Ransohoff RM, Shi FD. PMID: 18581322.
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    86. Leptin and Inflammation. Curr Immunol Rev. 2008 May 01; 4(2):70-79. Iikuni N, Lam QL, Lu L, Matarese G, La Cava A. PMID: 20198122.
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    87. T-regulatory cells in systemic lupus erythematosus. Lupus. 2008 May; 17(5):421-5. La Cava A. PMID: 18490420.
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    88. pConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating Foxp3 and PD1 molecules. J Immunol. 2008 Feb 15; 180(4):2069-80. Singh RP, La Cava A, Hahn BH. PMID: 18250412.
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    89. New therapies in SLE. Recent Pat Inflamm Allergy Drug Discov. 2008 Jan; 2(1):11-23. Ferrera F, Filaci G, Rizzi M, Singh RP, Indiveri F, Hahn BH, La Cava A. PMID: 19075989.
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    90. Regulatory CD4 T cells: sensing the environment. Trends Immunol. 2008 Jan; 29(1):12-7. Matarese G, De Rosa V, La Cava A. PMID: 18289503.
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    91. IL-21 receptor expression determines the temporal phases of experimental autoimmune encephalomyelitis. Exp Neurol. 2008 May; 211(1):14-24. Liu R, Bai Y, Vollmer TL, Bai XF, Jee Y, Tang YY, Campagnolo DI, Collins M, Young DA, La Cava A, Shi FD. PMID: 18353312.
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    92. Gene vaccination for the induction of immune tolerance. Ann N Y Acad Sci. 2007 Sep; 1110:99-111. Ferrera F, La Cava A, Rizzi M, Hahn BH, Indiveri F, Filaci G. PMID: 17911425.
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    93. CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression. J Immunol. 2007 Jun 15; 178(12):7649-57. Singh RP, La Cava A, Wong M, Ebling F, Hahn BH. PMID: 17548601.
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    94. Protection against renal disease in (NZB x NZW)F(1) lupus-prone mice after somatic B cell gene vaccination with anti-DNA immunoglobulin consensus peptide. Arthritis Rheum. 2007 Jun; 56(6):1945-53. Ferrera F, Hahn BH, Rizzi M, Anderson M, Fitzgerald J, Millo E, Indiveri F, Shi FD, Filaci G, La Cava A. PMID: 17530718.
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    95. A key role of leptin in the control of regulatory T cell proliferation. Immunity. 2007 Feb; 26(2):241-55. De Rosa V, Procaccini C, Calì G, Pirozzi G, Fontana S, Zappacosta S, La Cava A, Matarese G. PMID: 17307705.
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    96. ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia. J Lipid Res. 2007 Apr; 48(4):794-805. Feng X, Li H, Rumbin AA, Wang X, La Cava A, Brechtelsbauer K, Castellani LW, Witztum JL, Lusis AJ, Tsao BP. PMID: 17259598.
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    97. Leptin and adipocytokines: bridging the gap between immunity and atherosclerosis. Curr Pharm Des. 2007; 13(36):3676-80. Matarese G, Mantzoros C, La Cava A. PMID: 18220805.
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    98. CD4+CD25+ Tregs and NKT cells: regulators regulating regulators. Trends Immunol. 2006 Jul; 27(7):322-7. La Cava A, Van Kaer L, Fu-Dong-Shi . PMID: 16735139.
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    99. Autoreactive T cells mediate NK cell degeneration in autoimmune disease. J Immunol. 2006 May 01; 176(9):5247-54. Liu R, Van Kaer L, La Cava A, Price M, Campagnolo DI, Collins M, Young DA, Vollmer TL, Shi FD. PMID: 16621990.
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    100. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J Clin Invest. 2006 Feb; 116(2):447-55. De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti GF, Fontana S, Zappacosta S, Matarese G. PMID: 16410832; PMCID: PMC1326145.
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    101. Natural and adaptive immune cell-based therapies in autoimmunity. Curr Med Chem. 2006; 13(13):1557-66. La Cava A, Shi FD. PMID: 16787203.
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    102. Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia. J Immunol. 2005 Dec 15; 175(12):7898-904. Liu R, La Cava A, Bai XF, Jee Y, Price M, Campagnolo DI, Christadoss P, Vollmer TL, Van Kaer L, Shi FD. PMID: 16339525.
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    103. Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFbeta-secreting CD8+ T cell suppressors. J Immunol. 2005 Dec 01; 175(11):7728-37. Hahn BH, Singh RP, La Cava A, Ebling FM. PMID: 16301683.
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    104. Manipulation of immune regulation in systemic lupus erythematosus. Autoimmun Rev. 2005 Nov; 4(8):515-9. La Cava A, Fang CJ, Singh RP, Ebling F, Hahn BH. PMID: 16214088.
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    105. Cellular and molecular mechanisms of regulation of autoantibody production in lupus. Ann N Y Acad Sci. 2005 Jun; 1051:433-41. Hahn BH, Ebling F, Singh RR, Singh RP, Karpouzas G, La Cava A. PMID: 16126985.
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    106. Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5150-5. Matarese G, Carrieri PB, La Cava A, Perna F, Sanna V, De Rosa V, Aufiero D, Fontana S, Zappacosta S. PMID: 15788534.
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    107. Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J Immunol. 2005 Mar 01; 174(5):2696-701. Vollmer TL, Liu R, Price M, Rhodes S, La Cava A, Shi FD. PMID: 15728477.
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    108. Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model. Eur J Immunol. 2004 Sep; 34(9):2489-99. Karpouzas GA, La Cava A, Ebling FM, Singh RR, Hahn BH. PMID: 15307181.
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    109. Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA. J Immunol. 2004 Sep 01; 173(5):3542-8. La Cava A, Ebling FM, Hahn BH. PMID: 15322219.
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    110. The weight of leptin in immunity. Nat Rev Immunol. 2004 May; 4(5):371-9. La Cava A, Matarese G. PMID: 15122202.
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    111. The intricate interface between immune system and metabolism. Trends Immunol. 2004 Apr; 25(4):193-200. Matarese G, La Cava A. PMID: 15039046.
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    112. Leptin-based immune intervention: current status and future directions. Curr Opin Investig Drugs. 2003 Nov; 4(11):1327-32. La Cava A, Matarese G, Ebling FM, Hahn BH. PMID: 14758772.
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    113. Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med (Berl). 2004 Jan; 82(1):4-11. La Cava A, Alviggi C, Matarese G. PMID: 14556053.
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    114. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest. 2003 Jan; 111(2):241-50. Sanna V, Di Giacomo A, La Cava A, Lechler RI, Fontana S, Zappacosta S, Matarese G. PMID: 12531880; PMCID: PMC151876.
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    115. Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes. 2002 May; 51(5):1356-61. Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A. PMID: 11978630.
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    116. Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol. 2002 Apr; 23(4):182-7. Matarese G, La Cava A, Sanna V, Lord GM, Lechler RI, Fontana S, Zappacosta S. PMID: 11923112.
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    117. Genetic immunization maps T cell (auto)immune responses to self antigens homologous to exogenous proteins. Autoimmunity. 2002 Mar; 35(2):105-10. La Cava A, Massa M, Mendivil A, Martini A, Albani S. PMID: 12071433.
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