Beth Ann Lazazzera

Title(s)Associate Professor, MIMG
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    Collapse Biography 
    Collapse Education and Training
    University of Massachusetts, AmherstB.S.1989Microbiology
    University of Wisconsin, MadisonPh.D.1995Bacteriology
    Massachusetts Institute of TechnologyPost-Doc1999Microbiology
    Collapse Awards and Honors
    National Institutes of Health1990  - 1993Predoctoral Fellowship
    University of Wisconsin, Madison1994Herman Smythe Award
    Damon Runyon-Walter Winchell Foundation1996  - 1999Postdoctoral Fellowship
    Damon Runyon-Walter Winchell Foundation2000Alternate for Scholar Award

    Collapse Overview 
    Collapse Overview
    Beth Lazazzera received her Ph.D. in Bacteriology from the University of Wisconsin, Madison and was a postdoctoral fellow at MIT. She arrived at UCLA in 1999 and joined the Department of Microbiology, Immunology, and Molecular Genetics (MIMG). She has participated in numerous instructional activities at UCLA and has taught the course “Introduction to Microbiology”, MIMG101, from 2001-2018. Since 2019, she has taught the introductory biology course, LS7A, “Cell and Molecular Biology”. She has been participating in workshops offered by the Center for Education Innovation and Learning in the Sciences (CEILS) since its inception and was a Scientific Teaching Fellow at the Mobile Summer Institute at UCLA. Beyond her teaching at UCLA, she concurrently spent 5 years as one of the lead instructors for the Cold Spring Harbor Laboratory Advanced Bacterial Genetics Course. Dr. Lazazzera is a past Vice Chair of Undergraduate Education in MIMG, past-Chair of the Academic Senate Undergraduate Council, and is current the Chair of the Life Science Education Department.

    Dr. Lazazzera’s laboratory studies bacterial social behavior and evolution. They have identified mechanisms by which Gram-positive bacteria are able to communication using peptide signals and mechanisms by which these bacteria can form biofilms. They are currently collaborating to determine a mechanism to disrupt biofilms that form on orthopedic devices. They are also studying how disruption of translational quality control pathways can disrupt the social behavior of bacteria. This led to the finding that problems in translation will lead to a higher mutation rate, which contributes to increased frequency of antibiotic resistance development. Future work is aimed at understanding the molecular mechanisms that underlie these bacterial behaviors.

    Collapse Research 
    Collapse Research Activities and Funding
    Electro Magnetic Acoustic Transducer Network in the Enhancement of Anti-infective Strategies
    DA-ARMY W81XWH-18-1-0123Jun 1, 2018 - Nov 30, 2019
    6th ASM Conference on Cell-Cell Communication in Bacteria
    NIH R13AI134039Aug 10, 2017 - Jul 31, 2018
    Role: Principal Investigator
    Collaborative Research: The Role of Quality Control in Microbial Translation Role: Co-PI
    NSF MCB- 1716475Jun 1, 2017 - May 31, 2021
    Microbiology – Increased Translation Error Rates and Long-term Survival
    Army Research Office W911NF-15-1-0105Mar 30, 2015 - Mar 29, 2018
    Collaborative Research: The Role of Quality Control in Microbial Translation
    NSF MCB- 1412773Sep 1, 2014 - Aug 31, 2017
    Role: Co-PI
    Collaborative Research: The Role of Quality Control in Microbial Translation
    NSF MCB-1052493Apr 1, 2011 - Mar 31, 2014
    Role: Co-PI
    Mechanism of Peptide Signaling in Bacillus Subtilis
    NIH R01AI048616Mar 1, 2002 - Feb 28, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pulsed Electromagnetic Fields Disrupt Staphylococcus epidermidis Biofilms and Enhance the Antibiofilm Efficacy of Antibiotics. Microbiol Spectr. 2022 Oct 31; e0194922. Juncker RB, Lazazzera BA, Billi F. PMID: 36314923.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. The use of functionalized nanoparticles to treat Staphylococcus aureus-based surgical-site infections: a systematic review. J Appl Microbiol. 2021 Dec; 131(6):2659-2668. Juncker RB, Lazazzera BA, Billi F. PMID: 33735514.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli. J Mol Biol. 2020 12 04; 432(24):166716. Howitz N, Su T, Lazazzera BA. PMID: 33220263.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. Bactericidal activity of gallium-doped chitosan coatings against staphylococcal infection. J Appl Microbiol. 2019 Jan; 126(1):87-101. Ghalayani Esfahani A, Lazazzera B, Draghi L, Farè S, Chiesa R, De Nardo L, Billi F. PMID: 30329212.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Retraction for Anderson et al., "Assembly of Minicellulosomes on the Surface of Bacillus subtilis". Appl Environ Microbiol. 2018 02 15; 84(4). Anderson TD, Robson SA, Jiang XW, Malmirchegini GR, Fierobe HP, Lazazzera BA, Clubb RT. PMID: 29386191; PMCID: PMC5795080.
      View in: PubMed   Mentions:    Fields:    
    6. Quality Control by Isoleucyl-tRNA Synthetase of Bacillus subtilis Is Required for Efficient Sporulation. Sci Rep. 2017 01 31; 7:41763. Kermgard E, Yang Z, Michel AM, Simari R, Wong J, Ibba M, Lazazzera BA. PMID: 28139725; PMCID: PMC5282499.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    7. Genetics: Location affects sporulation. Nature. 2015 Sep 03; 525(7567):42-3. Lazazzera BA, Hughes D. PMID: 26287460.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    8. A new quorum-sensing system (TprA/PhrA) for Streptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster. Mol Microbiol. 2015 Jul; 97(2):229-43. Hoover SE, Perez AJ, Tsui HC, Sinha D, Smiley DL, DiMarchi RD, Winkler ME, Lazazzera BA. PMID: 25869931; PMCID: PMC4676566.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    9. Quality control and infiltration of translation by amino acids outside of the genetic code. Annu Rev Genet. 2014; 48:149-66. Bullwinkle T, Lazazzera B, Ibba M. PMID: 25195507.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    10. Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code. Elife. 2014 Jun 02; 3. Bullwinkle TJ, Reynolds NM, Raina M, Moghal A, Matsa E, Rajkovic A, Kayadibi H, Fazlollahi F, Ryan C, Howitz N, Faull KF, Lazazzera BA, Ibba M. PMID: 24891238; PMCID: PMC4066437.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    11. Identification of Bacillus subtilis SipW as a bifunctional signal peptidase that controls surface-adhered biofilm formation. J Bacteriol. 2012 Jun; 194(11):2781-90. Terra R, Stanley-Wall NR, Cao G, Lazazzera BA. PMID: 22328672; PMCID: PMC3370629.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    12. Assembly of minicellulosomes on the surface of Bacillus subtilis. Appl Environ Microbiol. 2011 Jul; 77(14):4849-58. Anderson TD, Robson SA, Jiang XW, Malmirchegini GR, Fierobe HP, Lazazzera BA, Clubb RT. PMID: 21622797; PMCID: PMC3147385.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    13. Cellular mechanisms that control mistranslation. Nat Rev Microbiol. 2010 Dec; 8(12):849-56. Reynolds NM, Lazazzera BA, Ibba M. PMID: 21079633.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    14. The phosphoenolpyruvate phosphotransferase system: as important for biofilm formation by Vibrio cholerae as it is for metabolism in Escherichia coli. J Bacteriol. 2010 Aug; 192(16):4083-5. Lazazzera BA. PMID: 20562301; PMCID: PMC2916425.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    15. Identification of residues important for cleavage of the extracellular signaling peptide CSF of Bacillus subtilis from its precursor protein. J Bacteriol. 2008 Oct; 190(20):6668-75. Lanigan-Gerdes S, Briceno G, Dooley AN, Faull KF, Lazazzera BA. PMID: 18689487; PMCID: PMC2566178.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    16. CSF, a species-specific extracellular signaling peptide for communication among strains of Bacillus subtilis and Bacillus mojavensis. J Bacteriol. 2008 Jun; 190(11):4095-9. Pottathil M, Jung A, Lazazzera BA. PMID: 18375560; PMCID: PMC2395031.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    17. Identification of subtilisin, Epr and Vpr as enzymes that produce CSF, an extracellular signalling peptide of Bacillus subtilis. Mol Microbiol. 2007 Sep; 65(5):1321-33. Lanigan-Gerdes S, Dooley AN, Faull KF, Lazazzera BA. PMID: 17666034.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    18. Defining the genetic differences between wild and domestic strains of Bacillus subtilis that affect poly-gamma-dl-glutamic acid production and biofilm formation. Mol Microbiol. 2005 Aug; 57(4):1143-58. Stanley NR, Lazazzera BA. PMID: 16091050.
      View in: PubMed   Mentions: 98     Fields:    Translation:Cells
    19. Lessons from DNA microarray analysis: the gene expression profile of biofilms. Curr Opin Microbiol. 2005 Apr; 8(2):222-7. Lazazzera BA. PMID: 15802256.
      View in: PubMed   Mentions: 54     Fields:    
    20. Environmental signals and regulatory pathways that influence biofilm formation. Mol Microbiol. 2004 May; 52(4):917-24. Stanley NR, Lazazzera BA. PMID: 15130114.
      View in: PubMed   Mentions: 105     Fields:    Translation:Cells
    21. Identification of AbrB-regulated genes involved in biofilm formation by Bacillus subtilis. Mol Microbiol. 2004 May; 52(3):847-60. Hamon MA, Stanley NR, Britton RA, Grossman AD, Lazazzera BA. PMID: 15101989; PMCID: PMC1409746.
      View in: PubMed   Mentions: 93     Fields:    Translation:Cells
    22. Identification of catabolite repression as a physiological regulator of biofilm formation by Bacillus subtilis by use of DNA microarrays. J Bacteriol. 2003 Mar; 185(6):1951-7. Stanley NR, Britton RA, Grossman AD, Lazazzera BA. PMID: 12618459; PMCID: PMC150146.
      View in: PubMed   Mentions: 82     Fields:    Translation:Cells
    23. The extracellular Phr peptide-Rap phosphatase signaling circuit of Bacillus subtilis. Front Biosci. 2003 Jan 01; 8:d32-45. Pottathil M, Lazazzera BA. PMID: 12456319.
      View in: PubMed   Mentions: 78     Fields:    Translation:Cells
    24. The sporulation transcription factor Spo0A is required for biofilm development in Bacillus subtilis. Mol Microbiol. 2001 Dec; 42(5):1199-209. Hamon MA, Lazazzera BA. PMID: 11886552.
      View in: PubMed   Mentions: 179     Fields:    Translation:Cells
    25. The intracellular function of extracellular signaling peptides. Peptides. 2001 Oct; 22(10):1519-27. Lazazzera BA. PMID: 11587781.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    26. Quorum sensing and starvation: signals for entry into stationary phase. Curr Opin Microbiol. 2000 Apr; 3(2):177-82. Lazazzera BA. PMID: 10744996.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
    27. An autoregulatory circuit affecting peptide signaling in Bacillus subtilis. J Bacteriol. 1999 Sep; 181(17):5193-200. Lazazzera BA, Kurtser IG, McQuade RS, Grossman AD. PMID: 10464187; PMCID: PMC94022.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    28. The ins and outs of peptide signaling. Trends Microbiol. 1998 Jul; 6(7):288-94. Lazazzera BA, Grossman AD. PMID: 9717218.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    29. An exported peptide functions intracellularly to contribute to cell density signaling in B. subtilis. Cell. 1997 Jun 13; 89(6):917-25. Lazazzera BA, Solomon JM, Grossman AD. PMID: 9200610.
      View in: PubMed   Mentions: 113     Fields:    Translation:Cells
    30. A regulatory switch involving a Clp ATPase. Bioessays. 1997 Jun; 19(6):455-8. Lazazzera BA, Grossman AD. PMID: 9204762.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Purification and characterization of an extracellular peptide factor that affects two different developmental pathways in Bacillus subtilis. Genes Dev. 1996 Aug 15; 10(16):2014-24. Solomon JM, Lazazzera BA, Grossman AD. PMID: 8769645.
      View in: PubMed   Mentions: 95     Fields:    Translation:Cells
    32. Characterization of FNR* mutant proteins indicates two distinct mechanisms for altering oxygen regulation of the Escherichia coli transcription factor FNR. J Bacteriol. 1995 Jul; 177(14):3972-8. Bates DM, Lazazzera BA, Kiley PJ. PMID: 7608069; PMCID: PMC177126.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    33. The activity of the Escherichia coli transcription factor FNR is regulated by a change in oligomeric state. Genes Dev. 1993 Oct; 7(10):1993-2005. Lazazzera BA, Bates DM, Kiley PJ. PMID: 8406003.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
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