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Discovering mechanisms of macrophage tissue infiltration with Drosophila. Curr Opin Immunol. 2024 Dec; 91:102502.
Siekhaus DE, Stanley-Ahmed JA. PMID: 39536472.
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HumansAnimalsCells
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Epithelial-immune interactions govern type 2 immunity at barrier surfaces. Curr Opin Immunol. 2024 Dec; 91:102501.
Lopez Espinoza A, Christopher T, Tait Wojno ED. PMID: 39522453; PMCID: PMC11734749.
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HumansAnimalsCells
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Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport. Proc Natl Acad Sci U S A. 2024 Mar 26; 121(13):e2319686121.
Boytsov D, Madej GM, Horn G, Blaha N, Köcher T, Sitte HH, Siekhaus D, Ziegler C, Sandtner W, Roblek M. PMID: 38507452; PMCID: PMC10990142.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Distinct role of TGN-resident clathrin adaptors for Vps21p activation in the TGN-endosome trafficking pathway. J Cell Sci. 2023 09 01; 136(17).
Nagano M, Aoshima K, Shimamura H, Siekhaus DE, Toshima JY, Toshima J. PMID: 37539494.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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The yeast endocytic early/sorting compartment exists as an independent sub-compartment within the trans-Golgi network. Elife. 2023 07 21; 12.
Toshima JY, Tsukahara A, Nagano M, Tojima T, Siekhaus DE, Nakano A, Toshima J. PMID: 37477116; PMCID: PMC10361720.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Eps15/Pan1p is a master regulator of the late stages of the endocytic pathway. J Cell Biol. 2022 10 03; 221(10).
Enshoji M, Miyano Y, Yoshida N, Nagano M, Watanabe M, Kunihiro M, Siekhaus DE, Toshima JY, Toshima J. PMID: 35984332; PMCID: PMC9396825.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Cell division in tissues enables macrophage infiltration. Science. 2022 04 22; 376(6591):394-396.
Akhmanova M, Emtenani S, Krueger D, Gyoergy A, Guarda M, Vlasov M, Vlasov F, Akopian A, Ratheesh A, De Renzis S, Siekhaus DE. PMID: 35446632.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. Dev Cell. 2022 04 11; 57(7):883-900.e10.
Martin ET, Blatt P, Nguyen E, Lahr R, Selvam S, Yoon HAM, Pocchiari T, Emtenani S, Siekhaus DE, Berman A, Fuchs G, Rangan P. PMID: 35413237; PMCID: PMC9011129.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila. EMBO J. 2022 06 14; 41(12):e109049.
Emtenani S, Martin ET, Gyoergy A, Bicher J, Genger JW, Köcher T, Akhmanova M, Guarda M, Roblek M, Bergthaler A, Hurd TR, Rangan P, Siekhaus DE. PMID: 35319107; PMCID: PMC9194793.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis. Front Oncol. 2022; 12:777634.
Roblek M, Bicher J, van Gogh M, György A, Seeböck R, Szulc B, Damme M, Olczak M, Borsig L, Siekhaus DE. PMID: 35211397; PMCID: PMC8861502.
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PubMed Mentions:
3
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Fos regulates macrophage infiltration against surrounding tissue resistance by a cortical actin-based mechanism in Drosophila. PLoS Biol. 2022 01; 20(1):e3001494.
Belyaeva V, Wachner S, Gyoergy A, Emtenani S, Gridchyn I, Akhmanova M, Linder M, Roblek M, Sibilia M, Siekhaus D. PMID: 34990456; PMCID: PMC8735623.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease. PLoS Genet. 2021 04; 17(4):e1009479.
Ingles-Prieto A, Furthmann N, Crossman SH, Tichy AM, Hoyer N, Petersen M, Zheden V, Biebl J, Reichhart E, Gyoergy A, Siekhaus DE, Soba P, Winklhofer KF, Janovjak H. PMID: 33857132; PMCID: PMC8049241.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila. Elife. 2020 01 20; 9.
Kierdorf K, Hersperger F, Sharrock J, Vincent CM, Ustaoglu P, Dou J, Gyoergy A, Groß O, Siekhaus DE, Dionne MS. PMID: 31944178; PMCID: PMC6996930.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Rab5-mediated endosome formation is regulated at the trans-Golgi network. Commun Biol. 2019; 2:419.
Nagano M, Toshima JY, Siekhaus DE, Toshima J. PMID: 31754649; PMCID: PMC6858330.
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PubMed Mentions:
34 Translation:
AnimalsCells
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A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. Elife. 2019 03 26; 8.
Valoskova K, Biebl J, Roblek M, Emtenani S, Gyoergy A, Misova M, Ratheesh A, Reis-Rodrigues P, Shkarina K, Larsen ISB, Vakhrushev SY, Clausen H, Siekhaus DE. PMID: 30910009; PMCID: PMC6435326.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis in Drosophila and Preserves the Glial Fate. J Neurosci. 2019 01 09; 39(2):238-255.
Trébuchet G, Cattenoz PB, Zsámboki J, Mazaud D, Siekhaus DE, Fanto M, Giangrande A. PMID: 30504274; PMCID: PMC6360283.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Drosophila TNF Modulates Tissue Tension in the Embryo to Facilitate Macrophage Invasive Migration. Dev Cell. 2018 05 07; 45(3):331-346.e7.
Ratheesh A, Biebl J, Vesela J, Smutny M, Papusheva E, Krens SFG, Kaufmann W, Gyoergy A, Casano AM, Siekhaus DE. PMID: 29738712.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Tools Allowing Independent Visualization and Genetic Manipulation of Drosophila melanogaster Macrophages and Surrounding Tissues. G3 (Bethesda). 2018 03 02; 8(3):845-857.
Gyoergy A, Roblek M, Ratheesh A, Valoskova K, Belyaeva V, Wachner S, Matsubayashi Y, Sánchez-Sánchez BJ, Stramer B, Siekhaus DE. PMID: 29321168; PMCID: PMC5844306.
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PubMed Mentions:
36 Fields:
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Distinct roles for plasma membrane PtdIns(4)P and PtdIns(4,5)P2 during receptor-mediated endocytosis in yeast. J Cell Sci. 2018 01 04; 131(1).
Yamamoto W, Wada S, Nagano M, Aoshima K, Siekhaus DE, Toshima JY, Toshima J. PMID: 29192062.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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A Moving Source of Matrix Components Is Essential for De Novo Basement Membrane Formation. Curr Biol. 2017 Nov 20; 27(22):3526-3534.e4.
Matsubayashi Y, Louani A, Dragu A, Sánchez-Sánchez BJ, Serna-Morales E, Yolland L, Gyoergy A, Vizcay G, Fleck RA, Heddleston JM, Chew TL, Siekhaus DE, Stramer BM. PMID: 29129537; PMCID: PMC5714436.
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PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
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Yeast Eps15-like endocytic protein Pan1p regulates the interaction between endocytic vesicles, endosomes and the actin cytoskeleton. Elife. 2016 Feb 25; 5.
Toshima JY, Furuya E, Nagano M, Kanno C, Sakamoto Y, Ebihara M, Siekhaus DE, Toshima J. PMID: 26914139; PMCID: PMC4775215.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Srv2/CAP is required for polarized actin cable assembly and patch internalization during clathrin-mediated endocytosis. J Cell Sci. 2016 Jan 15; 129(2):367-79.
Toshima JY, Horikomi C, Okada A, Hatori MN, Nagano M, Masuda A, Yamamoto W, Siekhaus DE, Toshima J. PMID: 26604224.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Drosophila immune cell migration and adhesion during embryonic development and larval immune responses. Curr Opin Cell Biol. 2015 Oct; 36:71-9.
Ratheesh A, Belyaeva V, Siekhaus DE. PMID: 26210104.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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The yeast Arf-GAP Glo3p is required for the endocytic recycling of cell surface proteins. Biochim Biophys Acta. 2015 Jan; 1853(1):144-56.
Kawada D, Kobayashi H, Tomita T, Nakata E, Nagano M, Siekhaus DE, Toshima JY, Toshima J. PMID: 25409928.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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Bifurcation of the endocytic pathway into Rab5-dependent and -independent transport to the vacuole. Nat Commun. 2014 Mar 25; 5:3498.
Toshima JY, Nishinoaki S, Sato Y, Yamamoto W, Furukawa D, Siekhaus DE, Sawaguchi A, Toshima J. PMID: 24667230.
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PubMed Mentions:
19 Fields:
Translation:
Cells
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Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. Dev Cell. 2011 Feb 15; 20(2):233-43.
DeGennaro M, Hurd TR, Siekhaus DE, Biteau B, Jasper H, Lehmann R. PMID: 21316590; PMCID: PMC3712085.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila. Nat Cell Biol. 2010 Jun; 12(6):605-10.
Siekhaus D, Haesemeyer M, Moffitt O, Lehmann R. PMID: 20495554; PMCID: PMC3006444.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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In vivo migration: a germ cell perspective. Annu Rev Cell Dev Biol. 2006; 22:237-65.
Kunwar PS, Siekhaus DE, Lehmann R. PMID: 16774460.
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PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
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Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant. Nat Cell Biol. 2003 Mar; 5(3):231-5.
Siekhaus DE, Drubin DG. PMID: 12598904.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development. Genetics. 2003 Jan; 163(1):227-37.
Rayburn LY, Gooding HC, Choksi SP, Maloney D, Kidd AR, Siekhaus DE, Bender M. PMID: 12586710; PMCID: PMC1462398.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion. J Biol Chem. 2000 Jun 09; 275(23):17886-93.
Hwang JR, Siekhaus DE, Fuller RS, Taghert PH, Lindberg I. PMID: 10749852.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior. J Neurosci. 1999 Aug 15; 19(16):6942-54.
Siekhaus DE, Fuller RS. PMID: 10436051; PMCID: PMC6782853.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells