Debora Rodrigues Sobreira

Title(s)Department Vice Chair, Biological Chemistry
SchoolMedicine
ORCID ORCID Icon0000-0002-2232-3922 Additional info
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    Other Positions
    Title(s)Assistant Professor, Biological Chemistry

    Title(s)Assistant Professor, Human Genetics


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    Debora Sobreira is committed to advancing our understanding of gene regulation within human tissues and cells, particularly in the context of complex diseases. To achieve this, her employ a wide range of cutting-edge technologies and systems, with a primary focus on transforming GWAS-identified genetic risk locations associated with metabolic diseases and traits into their functional roles, a process referred to as "Variants-to-Function" (V2F).
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes. Nat Metab. 2023 05; 5(5):861-879. Glunk V, Laber S, Sinnott-Armstrong N, Sobreira DR, Strobel SM, Batista TM, Kubitz P, Moud BN, Ebert H, Huang Y, Brandl B, Garbo G, Honecker J, Stirling DR, Abdennur N, Calabuig-Navarro V, Skurk T, Ocvirk S, Stemmer K, Cimini BA, Carpenter AE, Dankel SN, Lindgren CM, Hauner H, Nobrega MA, Claussnitzer M. PMID: 37253881; PMCID: PMC11533588.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    2. Genetics of sexually dimorphic adipose distribution in humans. Nat Genet. 2023 03; 55(3):461-470. Hansen GT, Sobreira DR, Weber ZT, Thornburg AG, Aneas I, Zhang L, Sakabe NJ, Joslin AC, Haddad GA, Strobel SM, Laber S, Sultana F, Sahebdel F, Khan K, Li YI, Claussnitzer M, Ye L, Battaglino RA, Nóbrega MA. PMID: 36797366; PMCID: PMC10375400.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    3. A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans. Sci Adv. 2022 Nov 25; 8(47):eade1942. Gray OA, Yoo J, Sobreira DR, Jousma J, Witonsky D, Sakabe NJ, Peng YJ, Prabhakar NR, Fang Y, Nobréga MA, Di Rienzo A. PMID: 36417539; PMCID: PMC9683707.
      View in: PubMed   Mentions: 10     Fields:    
    4. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women. Alzheimers Dement. 2023 03; 19(3):896-908. Chung J, Das A, Sun X, Sobreira DR, Leung YY, Igartua C, Mozaffari S, Chou YF, Thiagalingam S, Mez J, Zhang X, Jun GR, Stein TD, Kunkle BW, Martin ER, Pericak-Vance MA, Mayeux R, Haines JL, Schellenberg GD, Nobrega MA, Lunetta KL, Pinto JM, Wang LS, Ober C, Farrer LA. PMID: 35770850; PMCID: PMC9800643.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    5. Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region. Nat Commun. 2021 10 21; 12(1):6115. Aneas I, Decker DC, Howard CL, Sobreira DR, Sakabe NJ, Blaine KM, Stein MM, Hrusch CL, Montefiori LE, Tena J, Magnaye KM, Clay SM, Gern JE, Jackson DJ, Altman MC, Naureckas ET, Hogarth DK, White SR, Gomez-Skarmeta JL, Schoetler N, Ober C, Sperling AI, Nóbrega MA. PMID: 34675193; PMCID: PMC8531453.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    6. A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci. Nat Commun. 2021 09 06; 12(1):5253. Joslin AC, Sobreira DR, Hansen GT, Sakabe NJ, Aneas I, Montefiori LE, Farris KM, Gu J, Lehman DM, Ober C, He X, Nóbrega MA. PMID: 34489471; PMCID: PMC8421397.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    7. Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5. Science. 2021 06 04; 372(6546):1085-1091. Sobreira DR, Joslin AC, Zhang Q, Williamson I, Hansen GT, Farris KM, Sakabe NJ, Sinnott-Armstrong N, Bozek G, Jensen-Cody SO, Flippo KH, Ober C, Bickmore WA, Potthoff M, Chen M, Claussnitzer M, Aneas I, Nóbrega MA. PMID: 34083488; PMCID: PMC8386003.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    8. Regulatory Landscapes of Nppa and Nppb. Circ Res. 2021 01 08; 128(1):130-132. Sobreira DR, Nóbrega MA. PMID: 33411631; PMCID: PMC8717258.
      View in: PubMed   Mentions:    Fields:    
    9. Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth. Sci Adv. 2020 12; 6(49). Sakabe NJ, Aneas I, Knoblauch N, Sobreira DR, Clark N, Paz C, Horth C, Ziffra R, Kaur H, Liu X, Anderson R, Morrison J, Cheung VC, Grotegut C, Reddy TE, Jacobsson B, Hallman M, Teramo K, Murtha A, Kessler J, Grobman W, Zhang G, Muglia LJ, Rana S, Lynch VJ, Crawford GE, Ober C, He X, Nóbrega MA. PMID: 33268355; PMCID: PMC7710387.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    10. Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma. Commun Biol. 2020 11 13; 3(1):678. Helling BA, Sobreira DR, Hansen GT, Sakabe NJ, Luo K, Billstrand C, Laxman B, Nicolae RI, Nicolae DL, Bochkov YA, Gern JE, Nobrega MA, White SR, Ober C. PMID: 33188283; PMCID: PMC7666152.
      View in: PubMed   Mentions: 13  Translation:HumansCells
    11. A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. Cell. 2019 08 22; 178(5):1145-1158.e20. El Khattabi L, Zhao H, Kalchschmidt J, Young N, Jung S, Van Blerkom P, Kieffer-Kwon P, Kieffer-Kwon KR, Park S, Wang X, Krebs J, Tripathi S, Sakabe N, Sobreira DR, Huang SC, Rao SSP, Pruett N, Chauss D, Sadler E, Lopez A, Nóbrega MA, Aiden EL, Asturias FJ, Casellas R. PMID: 31402173; PMCID: PMC7533040.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    12. Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. Circ Res. 2018 08 03; 123(4):428-442. Boogerd CJ, Zhu X, Aneas I, Sakabe N, Zhang L, Sobreira DR, Montefiori L, Bogomolovas J, Joslin AC, Zhou B, Chen J, Nobrega MA, Evans SM. PMID: 29903739; PMCID: PMC6092109.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    13. A promoter interaction map for cardiovascular disease genetics. Elife. 2018 07 10; 7. Montefiori LE, Sobreira DR, Sakabe NJ, Aneas I, Joslin AC, Hansen GT, Bozek G, Moskowitz IP, McNally EM, Nóbrega MA. PMID: 29988018; PMCID: PMC6053306.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    14. DNA methylation in lung cells is associated with asthma endotypes and genetic risk. JCI Insight. 2016 12 08; 1(20):e90151. Nicodemus-Johnson J, Myers RA, Sakabe NJ, Sobreira DR, Hogarth DK, Naureckas ET, Sperling AI, Solway J, White SR, Nobrega MA, Nicolae DL, Gilad Y, Ober C. PMID: 27942592; PMCID: PMC5139904.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    15. Time course and side-by-side analysis of mesodermal, pre-myogenic, myogenic and differentiated cell markers in the chicken model for skeletal muscle formation. J Anat. 2015 Sep; 227(3):361-82. Berti F, Nogueira JM, Wöhrle S, Sobreira DR, Hawrot K, Dietrich S. PMID: 26278933; PMCID: PMC4560570.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    16. Dact genes are chordate specific regulators at the intersection of Wnt and Tgf-β signaling pathways. BMC Evol Biol. 2014 Aug 06; 14:157. Schubert FR, Sobreira DR, Janousek RG, Alvares LE, Dietrich S. PMID: 25099342; PMCID: PMC4236578.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    17. Evolutionarily conserved morphogenetic movements at the vertebrate head-trunk interface coordinate the transport and assembly of hypopharyngeal structures. Dev Biol. 2014 Jun 15; 390(2):231-46. Lours-Calet C, Alvares LE, El-Hanfy AS, Gandesha S, Walters EH, Sobreira DR, Wotton KR, Jorge EC, Lawson JA, Kelsey Lewis A, Tada M, Sharpe C, Kardon G, Dietrich S. PMID: 24662046; PMCID: PMC4010675.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    18. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014 Mar 20; 507(7492):371-5. Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA. PMID: 24646999; PMCID: PMC4113484.
      View in: PubMed   Mentions: 640     Fields:    Translation:HumansAnimalsCells
    19. Dact gene expression profiles suggest a role for this gene family in integrating Wnt and TGF-β signaling pathways during chicken limb development. Dev Dyn. 2014 Mar; 243(3):428-39. Sensiate LA, Sobreira DR, Da Veiga FC, Peterlini DJ, Pedrosa AV, Rirsch T, Joazeiro PP, Schubert FR, Collares-Buzato CB, Xavier-Neto J, Dietrich S, Alvares LE. PMID: 23417991.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Elastic fiber assembly in the adult mouse pubic symphysis during pregnancy and postpartum. Biol Reprod. 2012 May; 86(5):151, 1-10. Consonni SR, Werneck CC, Sobreira DR, Kühne F, Moraes SG, Alvares LE, Joazeiro PP. PMID: 22238283.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
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