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Deborah Ann Ferrington

Title(s)Professor-in-residence, Ophthalmology
SchoolMedicine
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    Mitochondrial defects in the retinal pigment epithelium and the CFH risk allele for age-related macular degeneration
    NIH R01EY028554Apr 1, 2018 - Mar 31, 2022
    Role: Principal Investigator
    Age-related macular degeneration,mitochondria and the CFH genotype
    NIH R01EY026012Aug 1, 2016 - Jul 31, 2020
    Role: Principal Investigator
    2015 Oxidative Stress and Disease Gordon Research Conference & Seminar
    NIH R13AG049527Feb 27, 2015 - Jul 31, 2015
    Role: Principal Investigator
    Immunoproteasome: A key component of the cellular stress response
    NIH R21AG032391Sep 15, 2008 - Aug 31, 2011
    Role: Principal Investigator
    Functional Proteomics of Aging
    NIH T32AG029796Apr 1, 2007 - Apr 30, 2023
    Role: Co-Principal Investigator
    Proteomics of altered protein in macular degeneration
    NIH R03EY014176Jan 1, 2004 - Nov 30, 2006
    Role: Principal Investigator
    PROTEIN MODIFICATION IN AGE-RELATED RETINAL DEGENERATION
    NIH R03AG019024Aug 15, 2001 - Jul 31, 2002
    Role: Principal Investigator
    Proteasome Function in the Aging Retina
    NIH R01EY013623Jul 1, 2001 - Jul 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Chaperone-mediated autophagy: the Achilles heel of the retinal pigment epithelium during age-related macular degeneration. Autophagy. 2026 Mar 04; 1-3. Jiménez-Loygorri JI, Cuervo AM, Ferrington DA, Boya P. PMID: 41778671.
      View in: PubMed   Mentions:
    2. Adaptive Optics Fluorescence Lifetime Imaging Ophthalmoscopy for Single-Cell-Resolved In Vivo Metabolic and Structural Imaging of the Human Retinal Pigment Epithelium. medRxiv. 2026 Feb 09. Liu R, Wang X, Corradetti G, Soylu C, Ferrington DA, Sadda SR, Zhang Y. PMID: 41728315; PMCID: PMC12919113.
      View in: PubMed   Mentions:
    3. Complement Factor H (Y402H) polymorphism for age-related macular degeneration alters retinal lipids. bioRxiv. 2026 Jan 07. Shang P, Hoang J, Hong E, Geng Z, Ambrosino H, Abnoosian E, Zhu X, Ma M, Wei-Navarro NA, Webber B, Qu J, Montezuma SR, Agbaga MP, Dutton JR, Ferrington DA. PMID: 41542493; PMCID: PMC12803267.
      View in: PubMed   Mentions:
    4. Defective chaperone-mediated autophagy in the retinal pigment epithelium of age-related macular degeneration patients. EMBO Mol Med. 2025 Dec; 17(12):3472-3495. Jiménez-Loygorri JI, Shang P, Bayramoglu I, Gómez-Sintes R, Martín-Segura A, Ambrosino H, Hoang J, Díaz A, Geng Z, Gavathiotis E, Dutton JR, Dengjel J, Cuervo AM, Ferrington DA, Boya P. PMID: 41168502; PMCID: PMC12686442.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Degradation of IL-4Ralpha by Immunoproteasome: implication in airway type 2 inflammation and hyperresponsiveness. Front Immunol. 2025; 16:1501898. Schaunaman N, Cervantes D, Ferrington DA, Chu HW. PMID: 40170850; PMCID: PMC11958175.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. How crosstalk between mitochondria, lysosomes, and other organelles can prevent or promote dry age-related macular degeneration. Exp Eye Res. 2025 Feb; 251:110219. Lakkaraju A, Boya P, Csete M, Ferrington DA, Hurley JB, Sadun AA, Shang P, Sharma R, Sinha D, Ueffing M, Brockerhoff SE. PMID: 39716681; PMCID: PMC12097137.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. The Complement Factor H (Y402H) risk polymorphism for age-related macular degeneration affects metabolism and response to oxidative stress in the retinal pigment epithelium. Free Radic Biol Med. 2024 Nov 20; 225:833-845. Shang P, Ambrosino H, Hoang J, Geng Z, Zhu X, Shen S, Eminhizer M, Hong E, Zhang M, Qu J, Du J, Montezuma SR, Dutton JR, Ferrington DA. PMID: 39491736; PMCID: PMC11662989.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. The Effect of a TLR3 Agonist on Airway Allergic Inflammation and Viral Infection in Immunoproteasome-Deficient Mice. Viruses. 2024 08 29; 16(9). Schaunaman N, Nichols T, Cervantes D, Hartsoe P, Ferrington DA, Chu HW. PMID: 39339860; PMCID: PMC11437510.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    9. The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD. Nat Commun. 2024 Jul 21; 15(1):6150. Ghosh S, Sharma R, Bammidi S, Koontz V, Nemani M, Yazdankhah M, Kedziora KM, Stolz DB, Wallace CT, Yu-Wei C, Franks J, Bose D, Shang P, Ambrosino HM, Dutton JR, Geng Z, Montford J, Ryu J, Rajasundaram D, Hose S, Sahel JA, Puertollano R, Finkel T, Zigler JS, Sergeev Y, Watkins SC, Goetzman ES, Ferrington DA, Flores-Bellver M, Kaarniranta K, Sodhi A, Bharti K, Handa JT, Sinha D. PMID: 39034314; PMCID: PMC11271488.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    10. QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration. Nat Commun. 2024 Mar 04; 15(1):1972. Advani J, Mehta PA, Hamel AR, Mehrotra S, Kiel C, Strunz T, Corso-Díaz X, Kwicklis M, van Asten F, Ratnapriya R, Chew EY, Hernandez DG, Montezuma SR, Ferrington DA, Weber BHF, Segrè AV, Swaroop A. PMID: 38438351; PMCID: PMC10912779.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    11. QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration. Res Sq. 2023 Jun 16. Advani J, Corso-Diaz X, Kwicklis M, van Asten F, Ratnapriya R, Mehta P, Hamel A, Mahrotra S, Segrè A, Kiel C, Strunz T, Weber B, Chew E, Hernandez D, Montezuma S, Ferrington D, Swaroop A. PMID: 37398472; PMCID: PMC10312909.
      View in: PubMed   Mentions:
    12. Quantitative Proteomics of Human Retinal Pigment Epithelium Reveals Key Regulators for the Pathogenesis of Age-Related Macular Degeneration. Int J Mol Sci. 2023 Feb 07; 24(4). Shen S, Kapphahn RJ, Zhang M, Qian S, Montezuma SR, Shang P, Ferrington DA, Qu J. PMID: 36834668; PMCID: PMC9959910.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. Investigating mitochondrial fission, fusion, and autophagy in retinal pigment epithelium from donors with age-related macular degeneration. Sci Rep. 2022 12 16; 12(1):21725. Fisher CR, Shaaeli AA, Ebeling MC, Montezuma SR, Ferrington DA. PMID: 36526679; PMCID: PMC9758189.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    14. Dissecting Regulators of Aging and Age-Related Macular Degeneration in the Retinal Pigment Epithelium. Oxid Med Cell Longev. 2022; 2022:6009787. Karunadharma PP, Kapphahn RJ, Stahl MR, Olsen TW, Ferrington DA. PMID: 36439688; PMCID: PMC9683958.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection. Sci Rep. 2022 08 25; 12(1):14507. Dimasuay KG, Schaunaman N, Berg B, Cervantes D, Kruger E, Heppner FL, Ferrington DA, Chu HW. PMID: 36008456; PMCID: PMC9403975.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration. Autophagy. 2023 03; 19(3):784-804. Ramírez-Pardo I, Villarejo-Zori B, Jiménez-Loygorri JI, Sierra-Filardi E, Alonso-Gil S, Mariño G, de la Villa P, Fitze PS, Fuentes JM, García-Escudero R, Ferrington DA, Gomez-Sintes R, Boya P. PMID: 35875981; PMCID: PMC9980615.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    17. Inflammasome Activation in Retinal Pigment Epithelium from Human Donors with Age-Related Macular Degeneration. Cells. 2022 06 30; 11(13). Ebeling MC, Fisher CR, Kapphahn RJ, Stahl MR, Shen S, Qu J, Montezuma SR, Ferrington DA. PMID: 35805159; PMCID: PMC9265516.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    18. Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction. Cell Rep. 2022 06 14; 39(11):110942. Sterling JK, Baumann B, Foshe S, Voigt A, Guttha S, Alnemri A, McCright SJ, Li M, Zauhar RJ, Montezuma SR, Kapphahn RJ, Chavali VRM, Hill DA, Ferrington DA, Stambolian D, Mullins RF, Merrick D, Dunaief JL. PMID: 35705048; PMCID: PMC9248858.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    19. Human iPSC- and Primary-Retinal Pigment Epithelial Cells for Modeling Age-Related Macular Degeneration. Antioxidants (Basel). 2022 Mar 22; 11(4). Fisher CR, Ebeling MC, Geng Z, Kapphahn RJ, Roehrich H, Montezuma SR, Dutton JR, Ferrington DA. PMID: 35453289; PMCID: PMC9025527.
      View in: PubMed   Mentions: 7  
    20. Quantification of mitophagy using mKeima-mito in cultured human primary retinal pigment epithelial cells. Exp Eye Res. 2022 04; 217:108981. Fisher CR, Ebeling MC, Ferrington DA. PMID: 35167864; PMCID: PMC8957530.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Testing Mitochondrial-Targeted Drugs in iPSC-RPE from Patients with Age-Related Macular Degeneration. Pharmaceuticals (Basel). 2022 Jan 04; 15(1). Ebeling MC, Geng Z, Stahl MR, Kapphahn RJ, Roehrich H, Montezuma SR, Ferrington DA, Dutton JR. PMID: 35056119; PMCID: PMC8781759.
      View in: PubMed   Mentions: 10  
    22. No association between cataract surgery and mitochondrial DNA damage with age-related macular degeneration in human donor eyes. PLoS One. 2021; 16(10):e0258803. Armbrust KR, Karunadharma PP, Terluk MR, Kapphahn RJ, Olsen TW, Ferrington DA, Montezuma SR. PMID: 34665838; PMCID: PMC8525771.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. OGT Regulates Mitochondrial Biogenesis and Function via Diabetes Susceptibility Gene Pdx1. Diabetes. 2021 11; 70(11):2608-2625. Mohan R, Jo S, Lockridge A, Ferrington DA, Murray K, Eschenlauer A, Bernal-Mizrachi E, Fujitani Y, Alejandro EU. PMID: 34462257; PMCID: PMC8564412.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    24. Glutathione Metabolism and the Novel Role of Mitochondrial GSH in Retinal Degeneration. Antioxidants (Basel). 2021 Apr 24; 10(5). Sreekumar PG, Ferrington DA, Kannan R. PMID: 33923192; PMCID: PMC8146950.
      View in: PubMed   Mentions: 57  
    25. Impaired Mitochondrial Function in iPSC-Retinal Pigment Epithelium with the Complement Factor H Polymorphism for Age-Related Macular Degeneration. Cells. 2021 04 02; 10(4). Ebeling MC, Geng Z, Kapphahn RJ, Roehrich H, Montezuma SR, Dutton JR, Ferrington DA. PMID: 33918210; PMCID: PMC8066149.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    26. Mitochondria: The Retina's Achilles' Heel in AMD. Adv Exp Med Biol. 2021; 1256:237-264. Ferrington DA, Kenney MC, Atilano SR, Hurley JB, Brown EE, Ash JD. PMID: 33848005.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    27. Automating Human Induced Pluripotent Stem Cell Culture and Differentiation of iPSC-Derived Retinal Pigment Epithelium for Personalized Drug Testing. SLAS Technol. 2021 06; 26(3):287-299. Truong V, Viken K, Geng Z, Barkan S, Johnson B, Ebeling MC, Montezuma SR, Ferrington DA, Dutton JR. PMID: 33292045; PMCID: PMC8140989.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    28. Family-based exome sequencing identifies rare coding variants in age-related macular degeneration. Hum Mol Genet. 2020 07 29; 29(12):2022-2034. Ratnapriya R, Acar IE, Geerlings MJ, Branham K, Kwong A, Saksens NTM, Pauper M, Corominas J, Kwicklis M, Zipprer D, Starostik MR, Othman M, Yashar B, Abecasis GR, Chew EY, Ferrington DA, Hoyng CB, Swaroop A, den Hollander AI. PMID: 32246154; PMCID: PMC7390936.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    29. Improving retinal mitochondrial function as a treatment for age-related macular degeneration. Redox Biol. 2020 07; 34:101552. Ebeling MC, Polanco JR, Qu J, Tu C, Montezuma SR, Ferrington DA. PMID: 32446621; PMCID: PMC7327959.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    30. Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. Prog Retin Eye Res. 2020 11; 79:100858. Kaarniranta K, Uusitalo H, Blasiak J, Felszeghy S, Kannan R, Kauppinen A, Salminen A, Sinha D, Ferrington D. PMID: 32298788; PMCID: PMC7650008.
      View in: PubMed   Mentions: 265     Fields:    Translation:HumansCells
    31. Investigating AKT activation and autophagy in immunoproteasome-deficient retinal cells. PLoS One. 2020; 15(4):e0231212. Karim MR, Fisher CR, Kapphahn RJ, Polanco JR, Ferrington DA. PMID: 32275682; PMCID: PMC7147741.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    32. Mitochondrial Defects Drive Degenerative Retinal Diseases. Trends Mol Med. 2020 01; 26(1):105-118. Ferrington DA, Fisher CR, Kowluru RA. PMID: 31771932; PMCID: PMC6938541.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    33. N-Acetyl-L-cysteine Protects Human Retinal Pigment Epithelial Cells from Oxidative Damage: Implications for Age-Related Macular Degeneration. Oxid Med Cell Longev. 2019; 2019:5174957. Terluk MR, Ebeling MC, Fisher CR, Kapphahn RJ, Yuan C, Kartha RV, Montezuma SR, Ferrington DA. PMID: 31485293; PMCID: PMC6710748.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    34. Author Correction: Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration. Nat Genet. 2019 Jun; 51(6):1067. Ratnapriya R, Sosina OA, Starostik MR, Kwicklis M, Kapphahn RJ, Fritsche LG, Walton A, Arvanitis M, Gieser L, Pietraszkiewicz A, Montezuma SR, Chew EY, Battle A, Abecasis GR, Ferrington DA, Chatterjee N, Swaroop A. PMID: 31068672.
      View in: PubMed   Mentions: 4     Fields:    
    35. Increased serum proteins in non-exudative AMD retinas. Exp Eye Res. 2019 09; 186:107686. Schultz H, Song Y, Baumann BH, Kapphahn RJ, Montezuma SR, Ferrington DA, Dunaief JL. PMID: 31158383; PMCID: PMC6703940.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    36. EDITORIAL: Special issue on the role of lipid and protein oxidation in retinal degenerations. Exp Eye Res. 2019 04; 181:313-315. Fliesler SJ, Ferrington DA. PMID: 30929716.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    37. Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy. Oxid Med Cell Longev. 2019; 2019:1583656. Hytti M, Korhonen E, Hyttinen JMT, Roehrich H, Kaarniranta K, Ferrington DA, Kauppinen A. PMID: 31007832; PMCID: PMC6441541.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    38. Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration. Nat Genet. 2019 04; 51(4):606-610. Ratnapriya R, Sosina OA, Starostik MR, Kwicklis M, Kapphahn RJ, Fritsche LG, Walton A, Arvanitis M, Gieser L, Pietraszkiewicz A, Montezuma SR, Chew EY, Battle A, Abecasis GR, Ferrington DA, Chatterjee N, Swaroop A. PMID: 30742112; PMCID: PMC6441365.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansCells
    39. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. Redox Biol. 2019 01; 20:1-12. Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. PMID: 30253279; PMCID: PMC6156745.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    40. Immunoproteasomes as a novel antiviral mechanism in rhinovirus-infected airways. Clin Sci (Lond). 2018 08 16; 132(15):1711-1723. Dimasuay KG, Sanchez A, Schaefer N, Polanco J, Ferrington DA, Chu HW. PMID: 29980604; PMCID: PMC7105891.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    41. Lipid-derived and other oxidative modifications of retinal proteins in a rat model of Smith-Lemli-Opitz syndrome. Exp Eye Res. 2019 01; 178:247-254. Kapphahn RJ, Richards MJ, Ferrington DA, Fliesler SJ. PMID: 30114413; PMCID: PMC6361703.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    42. Molecular Mechanisms Underlying Age-Related Ocular Diseases. Oxid Med Cell Longev. 2018; 2018:8476164. Amadio M, Kaarniranta K, Xu H, Smedowski A, Ferrington DA. PMID: 29951167; PMCID: PMC5987342.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Perspective on AMD Pathobiology: A Bioenergetic Crisis in the RPE. Invest Ophthalmol Vis Sci. 2018 03 20; 59(4):AMD41-AMD47. Fisher CR, Ferrington DA. PMID: 30025108; PMCID: PMC5989860.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    44. Downhill exercise alters immunoproteasome content in mouse skeletal muscle. Cell Stress Chaperones. 2018 07; 23(4):507-517. Baumann CW, Kwak D, Ferrington DA, Thompson LV. PMID: 29124664; PMCID: PMC6045542.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    45. Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration. Redox Biol. 2017 10; 13:255-265. Ferrington DA, Ebeling MC, Kapphahn RJ, Terluk MR, Fisher CR, Polanco JR, Roehrich H, Leary MM, Geng Z, Dutton JR, Montezuma SR. PMID: 28600982; PMCID: PMC5466586.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    46. Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration. PLoS One. 2017; 12(3):e0173575. Geng Z, Walsh PJ, Truong V, Hill C, Ebeling M, Kapphahn RJ, Montezuma SR, Yuan C, Roehrich H, Ferrington DA, Dutton JR. PMID: 28282420; PMCID: PMC5345835.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCellsCTClinical Trials
    47. Activating the AKT2-nuclear factor-κB-lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration. J Pathol. 2017 04; 241(5):583-588. Ghosh S, Shang P, Yazdankhah M, Bhutto I, Hose S, Montezuma SR, Luo T, Chattopadhyay S, Qian J, Lutty GA, Ferrington DA, Zigler JS, Sinha D. PMID: 28026019; PMCID: PMC5357190.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    48. Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. PLoS One. 2016; 11(11):e0166831. Liu HM, Ferrington DA, Baumann CW, Thompson LV. PMID: 27875560; PMCID: PMC5119786.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    49. Simultaneous determination of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in human retinal DNA by liquid chromatography nanoelectrospray-tandem mass spectrometry. Sci Rep. 2016 Mar 16; 6:22375. Ma B, Jing M, Villalta PW, Kapphahn RJ, Montezuma SR, Ferrington DA, Stepanov I. PMID: 26979577; PMCID: PMC4793187.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    50. Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration. Exp Eye Res. 2016 04; 145:269-277. Ferrington DA, Kapphahn RJ, Leary MM, Atilano SR, Terluk MR, Karunadharma P, Chen GK, Ratnapriya R, Swaroop A, Montezuma SR, Kenney MC. PMID: 26854823; PMCID: PMC4842097.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    51. Lactoferrin Expression in Human and Murine Ocular Tissue. Curr Eye Res. 2016 07; 41(7):883-9. Rageh AA, Ferrington DA, Roehrich H, Yuan C, Terluk MR, Nelson EF, Montezuma SR. PMID: 26431065; PMCID: PMC4818730.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    52. Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration. Prog Retin Eye Res. 2016 Mar; 51:69-89. Ferrington DA, Sinha D, Kaarniranta K. PMID: 26344735; PMCID: PMC4769684.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    53. Immunoproteasome deficiency protects in the retina after optic nerve crush. PLoS One. 2015; 10(5):e0126768. Schuld NJ, Hussong SA, Kapphahn RJ, Lehmann U, Roehrich H, Rageh AA, Heuss ND, Bratten W, Gregerson DS, Ferrington DA. PMID: 25978061; PMCID: PMC4433222.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    54. Investigating mitochondria as a target for treating age-related macular degeneration. J Neurosci. 2015 May 06; 35(18):7304-11. Terluk MR, Kapphahn RJ, Soukup LM, Gong H, Gallardo C, Montezuma SR, Ferrington DA. PMID: 25948278; PMCID: PMC4420790.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansCells
    55. Lactoferrin Reduces Chorioretinal Damage in the Murine Laser Model of Choroidal Neovascularization. Curr Eye Res. 2015 Sep; 40(9):946-53. Montezuma SR, Dolezal LD, Rageh AA, Mar K, Jordan M, Ferrington DA. PMID: 25835346.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    56. Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice. J Neuroinflammation. 2014 Aug 13; 11:143. Heuss ND, Pierson MJ, Montaniel KR, McPherson SW, Lehmann U, Hussong SA, Ferrington DA, Low WC, Gregerson DS. PMID: 25116321; PMCID: PMC4149240.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    57. Immunoproteasome in animal models of Duchenne muscular dystrophy. J Muscle Res Cell Motil. 2014 Apr; 35(2):191-201. Chen CN, Graber TG, Bratten WM, Ferrington DA, Thompson LV. PMID: 24934129; PMCID: PMC4130177.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    58. Immunoproteasome deficiency modifies the alternative pathway of NFκB signaling. PLoS One. 2013; 8(2):e56187. Maldonado M, Kapphahn RJ, Terluk MR, Heuss ND, Yuan C, Gregerson DS, Ferrington DA. PMID: 23457524; PMCID: PMC3572990.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    59. Corneal wound healing is compromised by immunoproteasome deficiency. PLoS One. 2013; 8(1):e54347. Ferrington DA, Roehrich H, Chang AA, Huang CW, Maldonado M, Bratten W, Rageh AA, Heuss ND, Gregerson DS, Nelson EF, Yuan C. PMID: 23365662; PMCID: PMC3554767.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    60. Immunoproteasomes: structure, function, and antigen presentation. Prog Mol Biol Transl Sci. 2012; 109:75-112. Ferrington DA, Gregerson DS. PMID: 22727420; PMCID: PMC4405001.
      View in: PubMed   Mentions: 228     Fields:    Translation:HumansAnimalsCells
    61. A novel role for the immunoproteasome in retinal function. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):714-23. Hussong SA, Roehrich H, Kapphahn RJ, Maldonado M, Pardue MT, Ferrington DA. PMID: 20881299; PMCID: PMC3053103.
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    62. Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5470-9. Karunadharma PP, Nordgaard CL, Olsen TW, Ferrington DA. PMID: 20505194; PMCID: PMC3061495.
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    63. Immunoproteasome deficiency alters retinal proteasome's response to stress. J Neurochem. 2010 Jun; 113(6):1481-90. Hussong SA, Kapphahn RJ, Phillips SL, Maldonado M, Ferrington DA. PMID: 20345760; PMCID: PMC2909641.
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    64. Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress. J Gerontol A Biol Sci Med Sci. 2010 Feb; 65(2):129-37. Chen CN, Brown-Borg HM, Rakoczy SG, Ferrington DA, Thompson LV. PMID: 20018823; PMCID: PMC2806238.
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    65. Site-specific methionine oxidation initiates calmodulin degradation by the 20S proteasome. Biochemistry. 2009 Apr 07; 48(13):3005-16. Balog EM, Lockamy EL, Thomas DD, Ferrington DA. PMID: 19231837; PMCID: PMC3664458.
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    66. Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading. J Appl Physiol (1985). 2008 Nov; 105(5):1554-61. Chen CN, Ferrington DA, Thompson LV. PMID: 18756007; PMCID: PMC2584842.
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    67. Immunoproteasome responds to injury in the retina and brain. J Neurochem. 2008 Jul; 106(1):158-69. Ferrington DA, Hussong SA, Roehrich H, Kapphahn RJ, Kavanaugh SM, Heuss ND, Gregerson DS. PMID: 18346202; PMCID: PMC4401486.
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    68. Human retinal pigment epithelium proteome changes in early diabetes. Diabetologia. 2008 Jun; 51(6):1051-61. Decanini A, Karunadharma PR, Nordgaard CL, Feng X, Olsen TW, Ferrington DA. PMID: 18414830; PMCID: PMC4397501.
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    69. Age-dependent effects of treadmill exercise during a period of inactivity. Exp Gerontol. 2008 Jul; 43(7):668-673. Arora P, Husom AD, Ferrington DA, Thompson LV. PMID: 18445515; PMCID: PMC2571116.
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    70. Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):2848-55. Nordgaard CL, Karunadharma PP, Feng X, Olsen TW, Ferrington DA. PMID: 18344451; PMCID: PMC4397576.
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    71. Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C613-26. Prochniewicz E, Lowe DA, Spakowicz DJ, Higgins L, O'Conor K, Thompson LV, Ferrington DA, Thomas DD. PMID: 18003749; PMCID: PMC4397896.
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    72. Interaction of retinal pigmented epithelial cells and CD4 T cells leads to T-cell anergy. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4654-63. Gregerson DS, Heuss ND, Lew KL, McPherson SW, Ferrington DA. PMID: 17898289.
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    73. Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal. Invest Ophthalmol Vis Sci. 2007 Aug; 48(8):3469-79. Ethen CM, Reilly C, Feng X, Olsen TW, Ferrington DA. PMID: 17652714.
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    74. Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration. Am J Ophthalmol. 2007 Apr; 143(4):607-15. Decanini A, Nordgaard CL, Feng X, Ferrington DA, Olsen TW. PMID: 17280640; PMCID: PMC2365890.
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    75. Transformation of the proteasome with age-related macular degeneration. FEBS Lett. 2007 Mar 06; 581(5):885-90. Ethen CM, Hussong SA, Reilly C, Feng X, Olsen TW, Ferrington DA. PMID: 17289037; PMCID: PMC1850528.
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    76. Age-dependent inhibition of proteasome chymotrypsin-like activity in the retina. Exp Eye Res. 2007 Apr; 84(4):646-54. Kapphahn RJ, Bigelow EJ, Ferrington DA. PMID: 17258201; PMCID: PMC1900430.
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    77. RPE cells resist bystander killing by CTLs, but are highly susceptible to antigen-dependent CTL killing. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5385-94. Gregerson DS, Lew KL, McPherson SW, Heuss ND, Ferrington DA. PMID: 17122128.
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    78. Protein nitration with aging in the rat semimembranosus and soleus muscles. J Gerontol A Biol Sci Med Sci. 2006 Aug; 61(8):806-12. Fugere NA, Ferrington DA, Thompson LV. PMID: 16912096; PMCID: PMC2692712.
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    79. Myosin and actin expression and oxidation in aging muscle. J Appl Physiol (1985). 2006 Dec; 101(6):1581-7. Thompson LV, Durand D, Fugere NA, Ferrington DA. PMID: 16840579; PMCID: PMC4394392.
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    80. The proteome of central and peripheral retina with progression of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2280-90. Ethen CM, Reilly C, Feng X, Olsen TW, Ferrington DA. PMID: 16723435.
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    81. Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells. Exp Eye Res. 2006 Sep; 83(3):638-50. Ferrington DA, Tran TN, Lew KL, Van Remmen H, Gregerson DS. PMID: 16682026.
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    82. Retinal proteins modified by 4-hydroxynonenal: identification of molecular targets. Exp Eye Res. 2006 Jul; 83(1):165-75. Kapphahn RJ, Giwa BM, Berg KM, Roehrich H, Feng X, Olsen TW, Ferrington DA. PMID: 16530755.
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    83. Proteomics of the retinal pigment epithelium reveals altered protein expression at progressive stages of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):815-22. Nordgaard CL, Berg KM, Kapphahn RJ, Reilly C, Feng X, Olsen TW, Ferrington DA. PMID: 16505012.
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    84. Declines in arrestin and rhodopsin in the macula with progression of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):769-75. Ethen CM, Feng X, Olsen TW, Ferrington DA. PMID: 15728529.
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    85. Altered proteasome structure, function, and oxidation in aged muscle. FASEB J. 2005 Apr; 19(6):644-6. Ferrington DA, Husom AD, Thompson LV. PMID: 15677694.
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    86. Age-related differences in the adaptive potential of type I skeletal muscle fibers. Exp Gerontol. 2005 Mar; 40(3):227-35. Husom AD, Ferrington DA, Thompson LV. PMID: 15763400.
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    87. Catalytic site-specific inhibition of the 20S proteasome by 4-hydroxynonenal. FEBS Lett. 2004 Dec 17; 578(3):217-23. Ferrington DA, Kapphahn RJ. PMID: 15589823.
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    88. Identification of a novel phosphorylation site in ataxin-1. Biochim Biophys Acta. 2005 May 15; 1744(1):11-8. Vierra-Green CA, Orr HT, Zoghbi HY, Ferrington DA. PMID: 15878393.
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    89. Myofibrillar myosin ATPase activity in hindlimb muscles from young and aged rats. Mech Ageing Dev. 2004 Sep; 125(9):619-27. Lowe DA, Husom AD, Ferrington DA, Thompson LV. PMID: 15491680; PMCID: PMC4405002.
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    90. Continuous remodeling of adult extraocular muscles as an explanation for selective craniofacial vulnerability in oculopharyngeal muscular dystrophy. J Neuroophthalmol. 2004 Mar; 24(1):62-7. Wirtschafter JD, Ferrington DA, McLoon LK. PMID: 15206442.
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    91. Altered proteasome function and subunit composition in aged muscle. Arch Biochem Biophys. 2004 Jan 01; 421(1):67-76. Husom AD, Peters EA, Kolling EA, Fugere NA, Thompson LV, Ferrington DA. PMID: 14678786.
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    92. Modified alpha A crystallin in the retina: altered expression and truncation with aging. Biochemistry. 2003 Dec 30; 42(51):15310-25. Kapphahn RJ, Ethen CM, Peters EA, Higgins L, Ferrington DA. PMID: 14690441.
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    93. Comparable levels of Ca-ATPase inhibition by phospholamban in slow-twitch skeletal and cardiac sarcoplasmic reticulum. Biochemistry. 2002 Nov 05; 41(44):13289-96. Ferrington DA, Yao Q, Squier TC, Bigelow DJ. PMID: 12403631.
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    94. Covalent modification of epithelial fatty acid-binding protein by 4-hydroxynonenal in vitro and in vivo. Evidence for a role in antioxidant biology. J Biol Chem. 2002 Dec 27; 277(52):50693-702. Bennaars-Eiden A, Higgins L, Hertzel AV, Kapphahn RJ, Ferrington DA, Bernlohr DA. PMID: 12386159.
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    95. Proteasome function and protein oxidation in the aged retina. Exp Eye Res. 2002 Sep; 75(3):271-84. Louie JL, Kapphahn RJ, Ferrington DA. PMID: 12384090.
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    96. Selective degradation of oxidized calmodulin by the 20 S proteasome. J Biol Chem. 2001 Jan 12; 276(2):937-43. Ferrington DA, Sun H, Murray KK, Costa J, Williams TD, Bigelow DJ, Squier TC. PMID: 11010965.
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    97. Electron paramagnetic resonance: a high-resolution tool for muscle physiology. Exerc Sport Sci Rev. 2001; 29(1):3-6. Thompson LV, Lowe DA, Ferrington DA, Thomas DD. PMID: 11210444; PMCID: PMC4404760.
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    98. Closer proximity between opposing domains of vertebrate calmodulin following deletion of Met(145)-Lys(148). Biochemistry. 2000 Aug 22; 39(33):10255-68. Yin D, Sun H, Ferrington DA, Squier TC. PMID: 10956015.
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    99. Diastereoselective reduction of protein-bound methionine sulfoxide by methionine sulfoxide reductase. FEBS Lett. 1999 Jul 23; 455(3):247-50. Sharov VS, Ferrington DA, Squier TC, Schöneich C. PMID: 10437782.
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    100. Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle. Biochem J. 1999 Jun 15; 340 ( Pt 3):657-69. Viner RI, Ferrington DA, Williams TD, Bigelow DJ, Schöneich C. PMID: 10359649; PMCID: PMC1220296.
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    101. Age-related chemical modification of the skeletal muscle sarcoplasmic reticulum Ca-ATPase of the rat. Mech Ageing Dev. 1999 Mar 15; 107(3):221-31. Schöneich C, Viner RI, Ferrington DA, Bigelow DJ. PMID: 10360678.
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    102. Effects of dietary protein on enzyme activity following exercise-induced muscle injury. Med Sci Sports Exerc. 1999 Mar; 31(3):414-20. Hayward R, Ferrington DA, Kochanowski LA, Miller LM, Jaworsky GM, Schneider CM. PMID: 10188746.
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    103. Repair of oxidized calmodulin by methionine sulfoxide reductase restores ability to activate the plasma membrane Ca-ATPase. Biochemistry. 1999 Jan 05; 38(1):105-12. Sun H, Gao J, Ferrington DA, Biesiada H, Williams TD, Squier TC. PMID: 9890888.
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    104. Altered turnover of calcium regulatory proteins of the sarcoplasmic reticulum in aged skeletal muscle. J Biol Chem. 1998 Mar 06; 273(10):5885-91. Ferrington DA, Krainev AG, Bigelow DJ. PMID: 9488726.
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    105. Protein half-lives of two subunits of an NMDA receptor-like complex, the 71-kDa glutamate-binding and the 80-kDa CPP-binding protein. Biochem Biophys Res Commun. 1997 Dec 08; 241(1):132-5. Chen X, Ferrington DA, Bigelow DJ, Michaelis EK. PMID: 9405246.
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    106. Decreased conformational stability of the sarcoplasmic reticulum Ca-ATPase in aged skeletal muscle. Biochim Biophys Acta. 1997 Dec 04; 1330(2):233-47. Ferrington DA, Jones TE, Qin Z, Miller-Schlyer M, Squier TC, Bigelow DJ. PMID: 9408177.
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    107. In vivo aging of rat skeletal muscle sarcoplasmic reticulum Ca-ATPase. Chemical analysis and quantitative simulation by exposure to low levels of peroxyl radicals. Biochim Biophys Acta. 1997 Oct 23; 1329(2):321-35. Viner RI, Ferrington DA, Aced GI, Miller-Schlyer M, Bigelow DJ, Schöneich C. PMID: 9371424.
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    108. Protein half-lives of calmodulin and the plasma membrane Ca-ATPase in rat brain. Biochem Biophys Res Commun. 1997 Aug 08; 237(1):163-5. Ferrington DA, Chen X, Krainev AG, Michaelis EK, Bigelow DJ. PMID: 9266850.
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    109. Activation of the sarcoplasmic reticulum Ca2+-ATPase induced by exercise. Biochim Biophys Acta. 1996 Mar 13; 1279(2):203-13. Ferrington DA, Reijneveld JC, Bär PR, Bigelow DJ. PMID: 8603088.
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    110. Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: a peroxynitrite-mediated process? FEBS Lett. 1996 Feb 05; 379(3):286-90. Viner RI, Ferrington DA, Hühmer AF, Bigelow DJ, Schöneich C. PMID: 8603707.
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    111. Adaptive changes in lipid composition of skeletal sarcoplasmic reticulum membranes associated with aging. Biochim Biophys Acta. 1995 May 04; 1235(2):406-18. Krainev AG, Ferrington DA, Williams TD, Squier TC, Bigelow DJ. PMID: 7756351.
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