Deborah Ann Ferrington

Title(s)Adjunct Instructor, Ophthalmology
SchoolMedicine
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    Mitochondrial defects in the retinal pigment epithelium and the CFH risk allele for age-related macular degeneration
    NIH R01EY028554Apr 1, 2018 - Mar 31, 2022
    Role: Principal Investigator
    Age-related macular degeneration,mitochondria and the CFH genotype
    NIH R01EY026012Aug 1, 2016 - Jul 31, 2020
    Role: Principal Investigator
    2015 Oxidative Stress and Disease Gordon Research Conference & Seminar
    NIH R13AG049527Feb 27, 2015 - Jul 31, 2015
    Role: Principal Investigator
    Immunoproteasome: A key component of the cellular stress response
    NIH R21AG032391Sep 15, 2008 - Aug 31, 2011
    Role: Principal Investigator
    Functional Proteomics of Aging
    NIH T32AG029796Apr 1, 2007 - Apr 30, 2023
    Role: Co-Principal Investigator
    Proteomics of altered protein in macular degeneration
    NIH R03EY014176Jan 1, 2004 - Nov 30, 2006
    Role: Principal Investigator
    PROTEIN MODIFICATION IN AGE-RELATED RETINAL DEGENERATION
    NIH R03AG019024Aug 15, 2001 - Jul 31, 2002
    Role: Principal Investigator
    Proteasome Function in the Aging Retina
    NIH R01EY013623Jul 1, 2001 - Jul 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration. Autophagy. 2022 Jul 24; 1-21. Ramírez-Pardo I, Villarejo-Zori B, Jiménez-Loygorri JI, Sierra-Filardi E, Alonso-Gil S, Mariño G, de la Villa P, Fitze PS, Fuentes JM, García-Escudero R, Ferrington DA, Gomez-Sintes R, Boya P. PMID: 35875981.
      View in: PubMed   Mentions:    Fields:    
    2. Inflammasome Activation in Retinal Pigment Epithelium from Human Donors with Age-Related Macular Degeneration. Cells. 2022 06 30; 11(13). Ebeling MC, Fisher CR, Kapphahn RJ, Stahl MR, Shen S, Qu J, Montezuma SR, Ferrington DA. PMID: 35805159; PMCID: PMC9265516.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction. Cell Rep. 2022 06 14; 39(11):110942. Sterling JK, Baumann B, Foshe S, Voigt A, Guttha S, Alnemri A, McCright SJ, Li M, Zauhar RJ, Montezuma SR, Kapphahn RJ, Chavali VRM, Hill DA, Ferrington DA, Stambolian D, Mullins RF, Merrick D, Dunaief JL. PMID: 35705048; PMCID: PMC9248858.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Human iPSC- and Primary-Retinal Pigment Epithelial Cells for Modeling Age-Related Macular Degeneration. Antioxidants (Basel). 2022 Mar 22; 11(4). Fisher CR, Ebeling MC, Geng Z, Kapphahn RJ, Roehrich H, Montezuma SR, Dutton JR, Ferrington DA. PMID: 35453289; PMCID: PMC9025527.
      View in: PubMed   Mentions: 1  
    5. Quantification of mitophagy using mKeima-mito in cultured human primary retinal pigment epithelial cells. Exp Eye Res. 2022 04; 217:108981. Fisher CR, Ebeling MC, Ferrington DA. PMID: 35167864; PMCID: PMC8957530.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Testing Mitochondrial-Targeted Drugs in iPSC-RPE from Patients with Age-Related Macular Degeneration. Pharmaceuticals (Basel). 2022 Jan 04; 15(1). Ebeling MC, Geng Z, Stahl MR, Kapphahn RJ, Roehrich H, Montezuma SR, Ferrington DA, Dutton JR. PMID: 35056119; PMCID: PMC8781759.
      View in: PubMed   Mentions: 1  
    7. No association between cataract surgery and mitochondrial DNA damage with age-related macular degeneration in human donor eyes. PLoS One. 2021; 16(10):e0258803. Armbrust KR, Karunadharma PP, Terluk MR, Kapphahn RJ, Olsen TW, Ferrington DA, Montezuma SR. PMID: 34665838; PMCID: PMC8525771.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. OGT Regulates Mitochondrial Biogenesis and Function via Diabetes Susceptibility Gene Pdx1. Diabetes. 2021 11; 70(11):2608-2625. Mohan R, Jo S, Lockridge A, Ferrington DA, Murray K, Eschenlauer A, Bernal-Mizrachi E, Fujitani Y, Alejandro EU. PMID: 34462257; PMCID: PMC8564412.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. Glutathione Metabolism and the Novel Role of Mitochondrial GSH in Retinal Degeneration. Antioxidants (Basel). 2021 Apr 24; 10(5). Sreekumar PG, Ferrington DA, Kannan R. PMID: 33923192; PMCID: PMC8146950.
      View in: PubMed   Mentions: 6  
    10. Impaired Mitochondrial Function in iPSC-Retinal Pigment Epithelium with the Complement Factor H Polymorphism for Age-Related Macular Degeneration. Cells. 2021 04 02; 10(4). Ebeling MC, Geng Z, Kapphahn RJ, Roehrich H, Montezuma SR, Dutton JR, Ferrington DA. PMID: 33918210; PMCID: PMC8066149.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    11. Mitochondria: The Retina's Achilles' Heel in AMD. Adv Exp Med Biol. 2021; 1256:237-264. Ferrington DA, Kenney MC, Atilano SR, Hurley JB, Brown EE, Ash JD. PMID: 33848005.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Automating Human Induced Pluripotent Stem Cell Culture and Differentiation of iPSC-Derived Retinal Pigment Epithelium for Personalized Drug Testing. SLAS Technol. 2021 06; 26(3):287-299. Truong V, Viken K, Geng Z, Barkan S, Johnson B, Ebeling MC, Montezuma SR, Ferrington DA, Dutton JR. PMID: 33292045; PMCID: PMC8140989.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Family-based exome sequencing identifies rare coding variants in age-related macular degeneration. Hum Mol Genet. 2020 07 29; 29(12):2022-2034. Ratnapriya R, Acar IE, Geerlings MJ, Branham K, Kwong A, Saksens NTM, Pauper M, Corominas J, Kwicklis M, Zipprer D, Starostik MR, Othman M, Yashar B, Abecasis GR, Chew EY, Ferrington DA, Hoyng CB, Swaroop A, den Hollander AI. PMID: 32246154; PMCID: PMC7390936.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Improving retinal mitochondrial function as a treatment for age-related macular degeneration. Redox Biol. 2020 07; 34:101552. Ebeling MC, Polanco JR, Qu J, Tu C, Montezuma SR, Ferrington DA. PMID: 32446621; PMCID: PMC7327959.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    15. Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. Prog Retin Eye Res. 2020 11; 79:100858. Kaarniranta K, Uusitalo H, Blasiak J, Felszeghy S, Kannan R, Kauppinen A, Salminen A, Sinha D, Ferrington D. PMID: 32298788; PMCID: PMC7650008.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    16. Investigating AKT activation and autophagy in immunoproteasome-deficient retinal cells. PLoS One. 2020; 15(4):e0231212. Karim MR, Fisher CR, Kapphahn RJ, Polanco JR, Ferrington DA. PMID: 32275682; PMCID: PMC7147741.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Mitochondrial Defects Drive Degenerative Retinal Diseases. Trends Mol Med. 2020 01; 26(1):105-118. Ferrington DA, Fisher CR, Kowluru RA. PMID: 31771932; PMCID: PMC6938541.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    18. N-Acetyl-L-cysteine Protects Human Retinal Pigment Epithelial Cells from Oxidative Damage: Implications for Age-Related Macular Degeneration. Oxid Med Cell Longev. 2019; 2019:5174957. Terluk MR, Ebeling MC, Fisher CR, Kapphahn RJ, Yuan C, Kartha RV, Montezuma SR, Ferrington DA. PMID: 31485293; PMCID: PMC6710748.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    19. Author Correction: Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration. Nat Genet. 2019 Jun; 51(6):1067. Ratnapriya R, Sosina OA, Starostik MR, Kwicklis M, Kapphahn RJ, Fritsche LG, Walton A, Arvanitis M, Gieser L, Pietraszkiewicz A, Montezuma SR, Chew EY, Battle A, Abecasis GR, Ferrington DA, Chatterjee N, Swaroop A. PMID: 31068672.
      View in: PubMed   Mentions: 3     Fields:    
    20. Increased serum proteins in non-exudative AMD retinas. Exp Eye Res. 2019 09; 186:107686. Schultz H, Song Y, Baumann BH, Kapphahn RJ, Montezuma SR, Ferrington DA, Dunaief JL. PMID: 31158383; PMCID: PMC6703940.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. EDITORIAL: Special issue on the role of lipid and protein oxidation in retinal degenerations. Exp Eye Res. 2019 04; 181:313-315. Fliesler SJ, Ferrington DA. PMID: 30929716.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    22. Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy. Oxid Med Cell Longev. 2019; 2019:1583656. Hytti M, Korhonen E, Hyttinen JMT, Roehrich H, Kaarniranta K, Ferrington DA, Kauppinen A. PMID: 31007832; PMCID: PMC6441541.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    23. Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration. Nat Genet. 2019 04; 51(4):606-610. Ratnapriya R, Sosina OA, Starostik MR, Kwicklis M, Kapphahn RJ, Fritsche LG, Walton A, Arvanitis M, Gieser L, Pietraszkiewicz A, Montezuma SR, Chew EY, Battle A, Abecasis GR, Ferrington DA, Chatterjee N, Swaroop A. PMID: 30742112; PMCID: PMC6441365.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    24. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. Redox Biol. 2019 01; 20:1-12. Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. PMID: 30253279; PMCID: PMC6156745.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    25. Immunoproteasomes as a novel antiviral mechanism in rhinovirus-infected airways. Clin Sci (Lond). 2018 08 16; 132(15):1711-1723. Dimasuay KG, Sanchez A, Schaefer N, Polanco J, Ferrington DA, Chu HW. PMID: 29980604; PMCID: PMC7105891.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    26. Lipid-derived and other oxidative modifications of retinal proteins in a rat model of Smith-Lemli-Opitz syndrome. Exp Eye Res. 2019 01; 178:247-254. Kapphahn RJ, Richards MJ, Ferrington DA, Fliesler SJ. PMID: 30114413; PMCID: PMC6361703.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    27. Molecular Mechanisms Underlying Age-Related Ocular Diseases. Oxid Med Cell Longev. 2018; 2018:8476164. Amadio M, Kaarniranta K, Xu H, Smedowski A, Ferrington DA. PMID: 29951167; PMCID: PMC5987342.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Perspective on AMD Pathobiology: A Bioenergetic Crisis in the RPE. Invest Ophthalmol Vis Sci. 2018 03 20; 59(4):AMD41-AMD47. Fisher CR, Ferrington DA. PMID: 30025108; PMCID: PMC5989860.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    29. Downhill exercise alters immunoproteasome content in mouse skeletal muscle. Cell Stress Chaperones. 2018 07; 23(4):507-517. Baumann CW, Kwak D, Ferrington DA, Thompson LV. PMID: 29124664; PMCID: PMC6045542.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    30. Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration. Redox Biol. 2017 10; 13:255-265. Ferrington DA, Ebeling MC, Kapphahn RJ, Terluk MR, Fisher CR, Polanco JR, Roehrich H, Leary MM, Geng Z, Dutton JR, Montezuma SR. PMID: 28600982; PMCID: PMC5466586.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    31. Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration. PLoS One. 2017; 12(3):e0173575. Geng Z, Walsh PJ, Truong V, Hill C, Ebeling M, Kapphahn RJ, Montezuma SR, Yuan C, Roehrich H, Ferrington DA, Dutton JR. PMID: 28282420; PMCID: PMC5345835.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsCTClinical Trials
    32. Activating the AKT2-nuclear factor-κB-lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration. J Pathol. 2017 04; 241(5):583-588. Ghosh S, Shang P, Yazdankhah M, Bhutto I, Hose S, Montezuma SR, Luo T, Chattopadhyay S, Qian J, Lutty GA, Ferrington DA, Zigler JS, Sinha D. PMID: 28026019; PMCID: PMC5357190.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    33. Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. PLoS One. 2016; 11(11):e0166831. Liu HM, Ferrington DA, Baumann CW, Thompson LV. PMID: 27875560; PMCID: PMC5119786.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    34. Simultaneous determination of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in human retinal DNA by liquid chromatography nanoelectrospray-tandem mass spectrometry. Sci Rep. 2016 Mar 16; 6:22375. Ma B, Jing M, Villalta PW, Kapphahn RJ, Montezuma SR, Ferrington DA, Stepanov I. PMID: 26979577; PMCID: PMC4793187.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    35. Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration. Exp Eye Res. 2016 04; 145:269-277. Ferrington DA, Kapphahn RJ, Leary MM, Atilano SR, Terluk MR, Karunadharma P, Chen GK, Ratnapriya R, Swaroop A, Montezuma SR, Kenney MC. PMID: 26854823; PMCID: PMC4842097.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    36. Lactoferrin Expression in Human and Murine Ocular Tissue. Curr Eye Res. 2016 07; 41(7):883-9. Rageh AA, Ferrington DA, Roehrich H, Yuan C, Terluk MR, Nelson EF, Montezuma SR. PMID: 26431065; PMCID: PMC4818730.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    37. Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration. Prog Retin Eye Res. 2016 Mar; 51:69-89. Ferrington DA, Sinha D, Kaarniranta K. PMID: 26344735; PMCID: PMC4769684.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    38. Immunoproteasome deficiency protects in the retina after optic nerve crush. PLoS One. 2015; 10(5):e0126768. Schuld NJ, Hussong SA, Kapphahn RJ, Lehmann U, Roehrich H, Rageh AA, Heuss ND, Bratten W, Gregerson DS, Ferrington DA. PMID: 25978061; PMCID: PMC4433222.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    39. Investigating mitochondria as a target for treating age-related macular degeneration. J Neurosci. 2015 May 06; 35(18):7304-11. Terluk MR, Kapphahn RJ, Soukup LM, Gong H, Gallardo C, Montezuma SR, Ferrington DA. PMID: 25948278; PMCID: PMC4420790.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    40. Lactoferrin Reduces Chorioretinal Damage in the Murine Laser Model of Choroidal Neovascularization. Curr Eye Res. 2015 Sep; 40(9):946-53. Montezuma SR, Dolezal LD, Rageh AA, Mar K, Jordan M, Ferrington DA. PMID: 25835346.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    41. Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice. J Neuroinflammation. 2014 Aug 13; 11:143. Heuss ND, Pierson MJ, Montaniel KR, McPherson SW, Lehmann U, Hussong SA, Ferrington DA, Low WC, Gregerson DS. PMID: 25116321; PMCID: PMC4149240.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    42. Immunoproteasome in animal models of Duchenne muscular dystrophy. J Muscle Res Cell Motil. 2014 Apr; 35(2):191-201. Chen CN, Graber TG, Bratten WM, Ferrington DA, Thompson LV. PMID: 24934129; PMCID: PMC4130177.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    43. Immunoproteasome deficiency modifies the alternative pathway of NFκB signaling. PLoS One. 2013; 8(2):e56187. Maldonado M, Kapphahn RJ, Terluk MR, Heuss ND, Yuan C, Gregerson DS, Ferrington DA. PMID: 23457524; PMCID: PMC3572990.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    44. Corneal wound healing is compromised by immunoproteasome deficiency. PLoS One. 2013; 8(1):e54347. Ferrington DA, Roehrich H, Chang AA, Huang CW, Maldonado M, Bratten W, Rageh AA, Heuss ND, Gregerson DS, Nelson EF, Yuan C. PMID: 23365662; PMCID: PMC3554767.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    45. Immunoproteasomes: structure, function, and antigen presentation. Prog Mol Biol Transl Sci. 2012; 109:75-112. Ferrington DA, Gregerson DS. PMID: 22727420; PMCID: PMC4405001.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansAnimalsCells
    46. A novel role for the immunoproteasome in retinal function. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):714-23. Hussong SA, Roehrich H, Kapphahn RJ, Maldonado M, Pardue MT, Ferrington DA. PMID: 20881299; PMCID: PMC3053103.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    47. Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5470-9. Karunadharma PP, Nordgaard CL, Olsen TW, Ferrington DA. PMID: 20505194; PMCID: PMC3061495.
      View in: PubMed   Mentions: 115     Fields:    Translation:Humans
    48. Immunoproteasome deficiency alters retinal proteasome's response to stress. J Neurochem. 2010 Jun; 113(6):1481-90. Hussong SA, Kapphahn RJ, Phillips SL, Maldonado M, Ferrington DA. PMID: 20345760; PMCID: PMC2909641.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    49. Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress. J Gerontol A Biol Sci Med Sci. 2010 Feb; 65(2):129-37. Chen CN, Brown-Borg HM, Rakoczy SG, Ferrington DA, Thompson LV. PMID: 20018823; PMCID: PMC2806238.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    50. Site-specific methionine oxidation initiates calmodulin degradation by the 20S proteasome. Biochemistry. 2009 Apr 07; 48(13):3005-16. Balog EM, Lockamy EL, Thomas DD, Ferrington DA. PMID: 19231837; PMCID: PMC3664458.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    51. Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading. J Appl Physiol (1985). 2008 Nov; 105(5):1554-61. Chen CN, Ferrington DA, Thompson LV. PMID: 18756007; PMCID: PMC2584842.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    52. Immunoproteasome responds to injury in the retina and brain. J Neurochem. 2008 Jul; 106(1):158-69. Ferrington DA, Hussong SA, Roehrich H, Kapphahn RJ, Kavanaugh SM, Heuss ND, Gregerson DS. PMID: 18346202; PMCID: PMC4401486.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    53. Human retinal pigment epithelium proteome changes in early diabetes. Diabetologia. 2008 Jun; 51(6):1051-61. Decanini A, Karunadharma PR, Nordgaard CL, Feng X, Olsen TW, Ferrington DA. PMID: 18414830; PMCID: PMC4397501.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    54. Age-dependent effects of treadmill exercise during a period of inactivity. Exp Gerontol. 2008 Jul; 43(7):668-673. Arora P, Husom AD, Ferrington DA, Thompson LV. PMID: 18445515; PMCID: PMC2571116.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    55. Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):2848-55. Nordgaard CL, Karunadharma PP, Feng X, Olsen TW, Ferrington DA. PMID: 18344451; PMCID: PMC4397576.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    56. Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C613-26. Prochniewicz E, Lowe DA, Spakowicz DJ, Higgins L, O'Conor K, Thompson LV, Ferrington DA, Thomas DD. PMID: 18003749; PMCID: PMC4397896.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    57. Interaction of retinal pigmented epithelial cells and CD4 T cells leads to T-cell anergy. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4654-63. Gregerson DS, Heuss ND, Lew KL, McPherson SW, Ferrington DA. PMID: 17898289.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    58. Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal. Invest Ophthalmol Vis Sci. 2007 Aug; 48(8):3469-79. Ethen CM, Reilly C, Feng X, Olsen TW, Ferrington DA. PMID: 17652714.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    59. Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration. Am J Ophthalmol. 2007 Apr; 143(4):607-15. Decanini A, Nordgaard CL, Feng X, Ferrington DA, Olsen TW. PMID: 17280640; PMCID: PMC2365890.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    60. Transformation of the proteasome with age-related macular degeneration. FEBS Lett. 2007 Mar 06; 581(5):885-90. Ethen CM, Hussong SA, Reilly C, Feng X, Olsen TW, Ferrington DA. PMID: 17289037; PMCID: PMC1850528.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    61. Age-dependent inhibition of proteasome chymotrypsin-like activity in the retina. Exp Eye Res. 2007 Apr; 84(4):646-54. Kapphahn RJ, Bigelow EJ, Ferrington DA. PMID: 17258201; PMCID: PMC1900430.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    62. RPE cells resist bystander killing by CTLs, but are highly susceptible to antigen-dependent CTL killing. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5385-94. Gregerson DS, Lew KL, McPherson SW, Heuss ND, Ferrington DA. PMID: 17122128.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    63. Protein nitration with aging in the rat semimembranosus and soleus muscles. J Gerontol A Biol Sci Med Sci. 2006 Aug; 61(8):806-12. Fugere NA, Ferrington DA, Thompson LV. PMID: 16912096; PMCID: PMC2692712.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    64. Myosin and actin expression and oxidation in aging muscle. J Appl Physiol (1985). 2006 Dec; 101(6):1581-7. Thompson LV, Durand D, Fugere NA, Ferrington DA. PMID: 16840579; PMCID: PMC4394392.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    65. The proteome of central and peripheral retina with progression of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2280-90. Ethen CM, Reilly C, Feng X, Olsen TW, Ferrington DA. PMID: 16723435.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    66. Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells. Exp Eye Res. 2006 Sep; 83(3):638-50. Ferrington DA, Tran TN, Lew KL, Van Remmen H, Gregerson DS. PMID: 16682026.
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    67. Retinal proteins modified by 4-hydroxynonenal: identification of molecular targets. Exp Eye Res. 2006 Jul; 83(1):165-75. Kapphahn RJ, Giwa BM, Berg KM, Roehrich H, Feng X, Olsen TW, Ferrington DA. PMID: 16530755.
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    68. Proteomics of the retinal pigment epithelium reveals altered protein expression at progressive stages of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):815-22. Nordgaard CL, Berg KM, Kapphahn RJ, Reilly C, Feng X, Olsen TW, Ferrington DA. PMID: 16505012.
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    69. Declines in arrestin and rhodopsin in the macula with progression of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):769-75. Ethen CM, Feng X, Olsen TW, Ferrington DA. PMID: 15728529.
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    70. Altered proteasome structure, function, and oxidation in aged muscle. FASEB J. 2005 Apr; 19(6):644-6. Ferrington DA, Husom AD, Thompson LV. PMID: 15677694.
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    71. Age-related differences in the adaptive potential of type I skeletal muscle fibers. Exp Gerontol. 2005 Mar; 40(3):227-35. Husom AD, Ferrington DA, Thompson LV. PMID: 15763400.
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    72. Catalytic site-specific inhibition of the 20S proteasome by 4-hydroxynonenal. FEBS Lett. 2004 Dec 17; 578(3):217-23. Ferrington DA, Kapphahn RJ. PMID: 15589823.
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    73. Identification of a novel phosphorylation site in ataxin-1. Biochim Biophys Acta. 2005 May 15; 1744(1):11-8. Vierra-Green CA, Orr HT, Zoghbi HY, Ferrington DA. PMID: 15878393.
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    74. Myofibrillar myosin ATPase activity in hindlimb muscles from young and aged rats. Mech Ageing Dev. 2004 Sep; 125(9):619-27. Lowe DA, Husom AD, Ferrington DA, Thompson LV. PMID: 15491680; PMCID: PMC4405002.
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    75. Continuous remodeling of adult extraocular muscles as an explanation for selective craniofacial vulnerability in oculopharyngeal muscular dystrophy. J Neuroophthalmol. 2004 Mar; 24(1):62-7. Wirtschafter JD, Ferrington DA, McLoon LK. PMID: 15206442.
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    76. Altered proteasome function and subunit composition in aged muscle. Arch Biochem Biophys. 2004 Jan 01; 421(1):67-76. Husom AD, Peters EA, Kolling EA, Fugere NA, Thompson LV, Ferrington DA. PMID: 14678786.
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    77. Modified alpha A crystallin in the retina: altered expression and truncation with aging. Biochemistry. 2003 Dec 30; 42(51):15310-25. Kapphahn RJ, Ethen CM, Peters EA, Higgins L, Ferrington DA. PMID: 14690441.
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    78. Comparable levels of Ca-ATPase inhibition by phospholamban in slow-twitch skeletal and cardiac sarcoplasmic reticulum. Biochemistry. 2002 Nov 05; 41(44):13289-96. Ferrington DA, Yao Q, Squier TC, Bigelow DJ. PMID: 12403631.
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    79. Covalent modification of epithelial fatty acid-binding protein by 4-hydroxynonenal in vitro and in vivo. Evidence for a role in antioxidant biology. J Biol Chem. 2002 Dec 27; 277(52):50693-702. Bennaars-Eiden A, Higgins L, Hertzel AV, Kapphahn RJ, Ferrington DA, Bernlohr DA. PMID: 12386159.
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    80. Proteasome function and protein oxidation in the aged retina. Exp Eye Res. 2002 Sep; 75(3):271-84. Louie JL, Kapphahn RJ, Ferrington DA. PMID: 12384090.
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    81. Selective degradation of oxidized calmodulin by the 20 S proteasome. J Biol Chem. 2001 Jan 12; 276(2):937-43. Ferrington DA, Sun H, Murray KK, Costa J, Williams TD, Bigelow DJ, Squier TC. PMID: 11010965.
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    82. Electron paramagnetic resonance: a high-resolution tool for muscle physiology. Exerc Sport Sci Rev. 2001; 29(1):3-6. Thompson LV, Lowe DA, Ferrington DA, Thomas DD. PMID: 11210444; PMCID: PMC4404760.
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    83. Closer proximity between opposing domains of vertebrate calmodulin following deletion of Met(145)-Lys(148). Biochemistry. 2000 Aug 22; 39(33):10255-68. Yin D, Sun H, Ferrington DA, Squier TC. PMID: 10956015.
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    84. Diastereoselective reduction of protein-bound methionine sulfoxide by methionine sulfoxide reductase. FEBS Lett. 1999 Jul 23; 455(3):247-50. Sharov VS, Ferrington DA, Squier TC, Schöneich C. PMID: 10437782.
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    85. Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle. Biochem J. 1999 Jun 15; 340 ( Pt 3):657-69. Viner RI, Ferrington DA, Williams TD, Bigelow DJ, Schöneich C. PMID: 10359649; PMCID: PMC1220296.
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    86. Age-related chemical modification of the skeletal muscle sarcoplasmic reticulum Ca-ATPase of the rat. Mech Ageing Dev. 1999 Mar 15; 107(3):221-31. Schöneich C, Viner RI, Ferrington DA, Bigelow DJ. PMID: 10360678.
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    87. Effects of dietary protein on enzyme activity following exercise-induced muscle injury. Med Sci Sports Exerc. 1999 Mar; 31(3):414-20. Hayward R, Ferrington DA, Kochanowski LA, Miller LM, Jaworsky GM, Schneider CM. PMID: 10188746.
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    88. Repair of oxidized calmodulin by methionine sulfoxide reductase restores ability to activate the plasma membrane Ca-ATPase. Biochemistry. 1999 Jan 05; 38(1):105-12. Sun H, Gao J, Ferrington DA, Biesiada H, Williams TD, Squier TC. PMID: 9890888.
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    89. Altered turnover of calcium regulatory proteins of the sarcoplasmic reticulum in aged skeletal muscle. J Biol Chem. 1998 Mar 06; 273(10):5885-91. Ferrington DA, Krainev AG, Bigelow DJ. PMID: 9488726.
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    90. Protein half-lives of two subunits of an NMDA receptor-like complex, the 71-kDa glutamate-binding and the 80-kDa CPP-binding protein. Biochem Biophys Res Commun. 1997 Dec 08; 241(1):132-5. Chen X, Ferrington DA, Bigelow DJ, Michaelis EK. PMID: 9405246.
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    91. Decreased conformational stability of the sarcoplasmic reticulum Ca-ATPase in aged skeletal muscle. Biochim Biophys Acta. 1997 Dec 04; 1330(2):233-47. Ferrington DA, Jones TE, Qin Z, Miller-Schlyer M, Squier TC, Bigelow DJ. PMID: 9408177.
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    92. In vivo aging of rat skeletal muscle sarcoplasmic reticulum Ca-ATPase. Chemical analysis and quantitative simulation by exposure to low levels of peroxyl radicals. Biochim Biophys Acta. 1997 Oct 23; 1329(2):321-35. Viner RI, Ferrington DA, Aced GI, Miller-Schlyer M, Bigelow DJ, Schöneich C. PMID: 9371424.
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    93. Protein half-lives of calmodulin and the plasma membrane Ca-ATPase in rat brain. Biochem Biophys Res Commun. 1997 Aug 08; 237(1):163-5. Ferrington DA, Chen X, Krainev AG, Michaelis EK, Bigelow DJ. PMID: 9266850.
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    94. Activation of the sarcoplasmic reticulum Ca2+-ATPase induced by exercise. Biochim Biophys Acta. 1996 Mar 13; 1279(2):203-13. Ferrington DA, Reijneveld JC, Bär PR, Bigelow DJ. PMID: 8603088.
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    95. Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: a peroxynitrite-mediated process? FEBS Lett. 1996 Feb 05; 379(3):286-90. Viner RI, Ferrington DA, Hühmer AF, Bigelow DJ, Schöneich C. PMID: 8603707.
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    96. Adaptive changes in lipid composition of skeletal sarcoplasmic reticulum membranes associated with aging. Biochim Biophys Acta. 1995 May 04; 1235(2):406-18. Krainev AG, Ferrington DA, Williams TD, Squier TC, Bigelow DJ. PMID: 7756351.
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