Gene D Block

Title(s)Professor, Psychiatry and Biobehavioral Sciences
SchoolMedicine
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    Sleeping sickness/cytokine effects on biological clock
    NIH R01HL071510Sep 21, 2002 - Jul 31, 2006
    Role: Principal Investigator
    Temporal Biology Training Program
    NIH T32NS044851Aug 15, 2002 - Jun 30, 2008
    Role: Co-Principal Investigator
    Neural Basis of Mammalian Circadian Organization
    NIH R01NS055361Dec 22, 2000 - Mar 31, 2010
    Role: Principal Investigator
    NEURAL BASIS OF MAMMALIAN CIRCADIAN ORGANIZATION
    NIH R01MH062517Dec 22, 2000 - Nov 30, 2004
    Role: Principal Investigator
    GORDON CONFERENCE ON CHRONOBIOLOGY
    NIH R13NS036771Aug 10, 1997 - Aug 15, 1997
    Role: Principal Investigator
    NEUROPHYSIOLOGICAL BASIS OF CIRCADIAN ORGANIZATION
    NIH K04NS000714Jul 1, 1983 - Jun 30, 1988
    Role: Principal Investigator
    NEURAL BASIS OF CIRCADIAN ORGANIZATION
    NIH R01NS015264Mar 1, 1979 - Feb 28, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dim Light at Night Disrupts the Sleep-Wake Cycle and Exacerbates Seizure Activity in Cntnap2 Knockout Mice: Implications for Autism Spectrum Disorders. bioRxiv. 2025 Mar 24. Wang Y, Paul KN, Block GD, Deboer T, Colwell CS. PMID: 40196643; PMCID: PMC11974761.
      View in: PubMed   Mentions:
    2. Long wavelength light reduces the negative consequences of dim light at night. Neurobiol Dis. 2023 01; 176:105944. Wang HB, Zhou D, Luk SHC, In Cha H, Mac A, Chae R, Matynia A, Harrison B, Afshari S, Block GD, Ghiani CA, Colwell CS. PMID: 36493974; PMCID: PMC10594349.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    3. Dietary ketosis improves circadian dysfunction as well as motor symptoms in the BACHD mouse model of Huntington's disease. Front Nutr. 2022; 9:1034743. Whittaker DS, Tamai TK, Bains RS, Villanueva SAM, Luk SHC, Dell'Angelica D, Block GD, Ghiani CA, Colwell CS. PMID: 36407529; PMCID: PMC9669764.
      View in: PubMed   Mentions: 9  
    4. Chronic methamphetamine uncovers a circadian rhythm in multiple-unit neural activity in the dorsal striatum which is independent of the suprachiasmatic nucleus. Neurobiol Sleep Circadian Rhythms. 2021 Nov; 11:100070. Miyazaki S, Tahara Y, Colwell CS, Block GD, Nakamura W, Nakamura TJ. PMID: 34307964; PMCID: PMC8258683.
      View in: PubMed   Mentions: 4  
    5. Support U.S. research during COVID-19. Science. 2020 Oct 30; 370(6516):539-540. Crow MM, Alger J, Amiridis M, Assanis D, Barron E, Becker MP, Blank RM, Block GD, Bollinger LC, Brown RA, Burwell SM, Cassidy CM, Clements JP, Currall S, DeGioia JJ, Frenk J, Fuchs WK, Gabel JTA, Gallagher PD, Gee EG, Isaacs E, Jacobs LA, Jahanian F, Jenkins J, Johnson KM, Kanter M, Kearns PK, Kennedy M, Khosla PK, Leshin L, Lovell M, May GS, Morehead J, Myers RB, Proenza LM, Rose C, Rudd MD, Sands TD, Schlissel MS, Stephens E, Stroble E, Subbaswamy K, Tripathi S, Watkins R, Weinberg A, Wilcox K, Wince-Smith D, Wintersteen W, Woodson WR, Zimmer RJ. PMID: 33122376.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    6. Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder. Neurobiol Dis. 2020 11; 145:105064. Wang HB, Tahara Y, Luk SHC, Kim YS, Hitchcock ON, MacDowell Kaswan ZA, In Kim Y, Block GD, Ghiani CA, Loh DH, Colwell CS. PMID: 32889171; PMCID: PMC7597927.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    7. Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease. J Biol Rhythms. 2018 10; 33(5):535-554. Whittaker DS, Loh DH, Wang HB, Tahara Y, Kuljis D, Cutler T, Ghiani CA, Shibata S, Block GD, Colwell CS. PMID: 30084274.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    8. Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats. Diabetes. 2018 03; 67(3):486-495. Kim YB, Kim WB, Jung WW, Jin X, Kim YS, Kim B, Han HC, Block GD, Colwell CS, Kim YI. PMID: 29212780.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    9. The Circadian Clock Gene Period1 Connects the Molecular Clock to Neural Activity in the Suprachiasmatic Nucleus. ASN Neuro. 2015 Nov-Dec; 7(6). Kudo T, Block GD, Colwell CS. PMID: 26553726; PMCID: PMC4710129.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    10. Age-Related Changes in the Circadian System Unmasked by Constant Conditions eNeuro. 2015 Jul-Aug; 2(4). Nakamura TJ, Nakamura W, Tokuda IT, Ishikawa T, Kudo T, Colwell CS, Block GD. PMID: 26464996; PMCID: PMC4596014.
      View in: PubMed   Mentions: 43     Fields:    
    11. Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period. Cell Rep. 2015 Sep 01; 12(9):1407-13. Takasu NN, Nakamura TJ, Tokuda IT, Todo T, Block GD, Nakamura W. PMID: 26299967.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    12. Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats. Diabetes. 2013 Oct; 62(10):3469-78. Qian J, Block GD, Colwell CS, Matveyenko AV. PMID: 23775768; PMCID: PMC3781472.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    13. Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleus. J Neurophysiol. 2013 Sep; 110(5):1097-106. Kudo T, Tahara Y, Gamble KL, McMahon DG, Block GD, Colwell CS. PMID: 23741043; PMCID: PMC4073931.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    14. Aging differentially affects the re-entrainment response of central and peripheral circadian oscillators. J Neurosci. 2012 Nov 14; 32(46):16193-202. Sellix MT, Evans JA, Leise TL, Castanon-Cervantes O, Hill DD, DeLisser P, Block GD, Menaker M, Davidson AJ. PMID: 23152603; PMCID: PMC3507430.
      View in: PubMed   Mentions: 77     Fields:    Translation:Animals
    15. Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction. J Biol Rhythms. 2011 Oct; 26(5):423-33. Gale JE, Cox HI, Qian J, Block GD, Colwell CS, Matveyenko AV. PMID: 21921296; PMCID: PMC3359760.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    16. Age-related decline in circadian output. J Neurosci. 2011 Jul 13; 31(28):10201-5. Nakamura TJ, Nakamura W, Yamazaki S, Kudo T, Cutler T, Colwell CS, Block GD. PMID: 21752996; PMCID: PMC3155746.
      View in: PubMed   Mentions: 164     Fields:    
    17. Effects of vasoactive intestinal peptide genotype on circadian gene expression in the suprachiasmatic nucleus and peripheral organs. J Biol Rhythms. 2011 Jun; 26(3):200-9. Loh DH, Dragich JM, Kudo T, Schroeder AM, Nakamura TJ, Waschek JA, Block GD, Colwell CS. PMID: 21628547; PMCID: PMC3942163.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    18. Clock gene expression during chronic inflammation induced by infection with Trypanosoma brucei brucei in rats. J Biol Rhythms. 2010 Apr; 25(2):92-102. Lundkvist GB, Sellix MT, Nygård M, Davis E, Straume M, Kristensson K, Block GD. PMID: 20348460; PMCID: PMC2897063.
      View in: PubMed   Mentions: 17     Fields:    
    19. Influence of the estrous cycle on clock gene expression in reproductive tissues: effects of fluctuating ovarian steroid hormone levels. Steroids. 2010 Mar; 75(3):203-12. Nakamura TJ, Sellix MT, Kudo T, Nakao N, Yoshimura T, Ebihara S, Colwell CS, Block GD. PMID: 20096720; PMCID: PMC2835461.
      View in: PubMed   Mentions: 33     Fields:    
    20. Ontogeny of circadian organization in the rat. J Biol Rhythms. 2009 Feb; 24(1):55-63. Yamazaki S, Yoshikawa T, Biscoe EW, Numano R, Gallaspy LM, Soulsby S, Papadimas E, Pezuk P, Doyle SE, Tei H, Sakaki Y, Block GD, Menaker M. PMID: 19150929; PMCID: PMC2665126.
      View in: PubMed   Mentions: 23     Fields:    
    21. Estrogen directly modulates circadian rhythms of PER2 expression in the uterus. Am J Physiol Endocrinol Metab. 2008 Nov; 295(5):E1025-31. Nakamura TJ, Sellix MT, Menaker M, Block GD. PMID: 18728223; PMCID: PMC2584820.
      View in: PubMed   Mentions: 54     Fields:    
    22. Interferon-gamma alters electrical activity and clock gene expression in suprachiasmatic nucleus neurons. J Biol Rhythms. 2008 Apr; 23(2):150-9. Kwak Y, Lundkvist GB, Brask J, Davidson A, Menaker M, Kristensson K, Block GD. PMID: 18375864.
      View in: PubMed   Mentions: 30     Fields:    
    23. In vivo monitoring of circadian timing in freely moving mice. Curr Biol. 2008 Mar 11; 18(5):381-5. Nakamura W, Yamazaki S, Nakamura TJ, Shirakawa T, Block GD, Takumi T. PMID: 18334203.
      View in: PubMed   Mentions: 41     Fields:    
    24. Seasonal encoding by the circadian pacemaker of the SCN. Curr Biol. 2007 Mar 06; 17(5):468-73. VanderLeest HT, Houben T, Michel S, Deboer T, Albus H, Vansteensel MJ, Block GD, Meijer JH. PMID: 17320387.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    25. Resetting of central and peripheral circadian oscillators in aged rats. Neurobiol Aging. 2008 Mar; 29(3):471-7. Davidson AJ, Yamazaki S, Arble DM, Menaker M, Block GD. PMID: 17129640; PMCID: PMC1635489.
      View in: PubMed   Mentions: 51     Fields:    
    26. Daily timed meals dissociate circadian rhythms in hepatoma and healthy host liver. Int J Cancer. 2006 Apr 01; 118(7):1623-7. Davidson AJ, Straume M, Block GD, Menaker M. PMID: 16231323; PMCID: PMC1464797.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    27. A calcium flux is required for circadian rhythm generation in mammalian pacemaker neurons. J Neurosci. 2005 Aug 17; 25(33):7682-6. Lundkvist GB, Kwak Y, Davis EK, Tei H, Block GD. PMID: 16107654; PMCID: PMC6725395.
      View in: PubMed   Mentions: 81     Fields:    
    28. Differential response of Period 1 expression within the suprachiasmatic nucleus. J Neurosci. 2005 Jun 08; 25(23):5481-7. Nakamura W, Yamazaki S, Takasu NN, Mishima K, Block GD. PMID: 15944376; PMCID: PMC6724974.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    29. A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock. Curr Biol. 2005 May 24; 15(10):886-93. Albus H, Vansteensel MJ, Michel S, Block GD, Meijer JH. PMID: 15916945.
      View in: PubMed   Mentions: 117     Fields:    Translation:Animals
    30. Keep time, stay healthy. Sci Aging Knowledge Environ. 2005 May 11; 2005(19):pe13. Block G. PMID: 15890664.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    31. Role of neuronal membrane events in circadian rhythm generation. Methods Enzymol. 2005; 393:623-42. Lundkvist GB, Block GD. PMID: 15817316.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    32. Plasticity of circadian behavior and the suprachiasmatic nucleus following exposure to non-24-hour light cycles. J Biol Rhythms. 2004 Jun; 19(3):198-207. Aton SJ, Block GD, Tei H, Yamazaki S, Herzog ED. PMID: 15155006.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    33. Thermochron ibuttons: an inexpensive method for long-term recording of core body temperature in untethered animals. J Biol Rhythms. 2003 Oct; 18(5):430-2. Davidson AJ, Aujard F, London B, Menaker M, Block GD. PMID: 14582859.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    34. Dissociation between circadian Per1 and neuronal and behavioral rhythms following a shifted environmental cycle. Curr Biol. 2003 Sep 02; 13(17):1538-42. Vansteensel MJ, Yamazaki S, Albus H, Deboer T, Block GD, Meijer JH. PMID: 12956957.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    35. Bulla gouldiana period exhibits unique regulation at the mRNA and protein levels. J Biol Rhythms. 2002 Oct; 17(5):413-27. Constance CM, Green CB, Tei H, Block GD. PMID: 12375618.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    36. Effects of aging on central and peripheral mammalian clocks. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10801-6. Yamazaki S, Straume M, Tei H, Sakaki Y, Menaker M, Block GD. PMID: 12149444; PMCID: PMC125050.
      View in: PubMed   Mentions: 113     Fields:    Translation:Animals
    37. Circadian rhythms in isolated brain regions. J Neurosci. 2002 Jan 01; 22(1):350-6. Abe M, Herzog ED, Yamazaki S, Straume M, Tei H, Sakaki Y, Menaker M, Block GD. PMID: 11756518; PMCID: PMC6757616.
      View in: PubMed   Mentions: 200     Fields:    Translation:AnimalsCells
    38. Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice invivo. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):489-94. Wilsbacher LD, Yamazaki S, Herzog ED, Song EJ, Radcliffe LA, Abe M, Block G, Spitznagel E, Menaker M, Takahashi JS. PMID: 11752392; PMCID: PMC117587.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
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