Jonathan David Herman

Title(s)Assistant Professor-in-residence, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0001-7188-4243 Additional info
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    Collapse Biography 
    Collapse education and training
    Brown University, Providence, RISc.B.2007
    Harvard Medical School, Boston, MAM.D.2016
    Harvard Medical School, Boston, MAPh.D.2016
    NewYork Presbyterian | Weill Cornell Medical Center, New York, NYResidency2018Internal Medicine
    Massachusetts General Hospital | Brigham and Women's Hospital, Boston, MAFellowship2022Infectious Disease
    Collapse awards and honors
    U.S. Department of State2007Fulbright Fellowship
    Harvard Medical School2016Henry Asbury Christian Award
    Doris Duke Charitable Foundation2021Physician Scientist Fellowship Award
    The American Society for Clinical Investigation2025Young Physician-Scientist Award

    Collapse Overview 
    Collapse overview
    Jonathan D. Herman, M.D., Ph.D., is a physician-scientist who investigates how the human immune system protects itself against infectious diseases. His research focuses on understanding vaccine-induced and natural immunity to pathogens like malaria, with the goal of developing new vaccines and therapies to prevent and treat infections.
    Herman employs advanced systems biology techniques to study how the human humoral immune system — specifically antibodies and B cells — responds to infections. His research program centers around analyzing these immune responses to develop effective vaccines and treatments for infectious diseases such as malaria, COVID-19 and HIV.

    He utilizes and develops systems-level tools to understand the human humoral immune system and then engineer it to protect patients from infectious disease. His current methodologies include systems serology to study Fc- and Fab-driven antibody responses; phage-display immunoprecipitation sequencing (PhIP-Seq) to measure whole-proteome anti-pathogen antibody responses; and the development of new antibody and B-cell technologies to interrogate antigen-specific responses at a massive scale.

    By integrating these findings, Herman aims to inform the design of next-generation vaccines and immunotherapies that can provide robust protection against malaria and other infectious diseases, ultimately improving global health outcomes.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. FcγR binding differentially contributes to protection by two human monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein. Science Translational Medicine. 2025; 17(795):eadk6745. Kisalu, N.K., Pereira, L.D.S., Herman, J.D., Asokan, M., Ernste, K., Merriam, J., Liu, C., Demouth, M.E., Pegu, A., Lofgren, M., Dillon, M., Bonilla, B., Macvicar, R., Zur, Y., Kiyuka, P., Flores-Garcia, Y., Chakraborty, S., Nikolaeva, D., Ogwang, R., Flynn, B., Francica, J., Pierson, T.C., Koup, R.A., Zavala, F., Wang, T.T., Alter, G., Idris, A.H., Seder, R.A. View Publication.
    2. Safety and protective efficacy of PfSPZ Vaccine administered to HIV-negative and -positive Tanzanian adults. J Clin Invest. 2024 Jan 09; 134(6). Jongo S, Church LWP, Milando F, Qassim M, Schindler T, Rashid M, Tumbo A, Nyaulingo G, Bakari BM, Athuman Mbaga T, Mohamed L, Kassimu K, Simon BS, Mpina M, Zaidi I, Duffy PE, Swanson PA, Seder R, Herman JD, Mendu M, Zur Y, Alter G, Kc N, Riyahi P, Abebe Y, Murshedkar T, James ER, Billingsley PF, Sim BKL, Richie TL, Daubenberger C, Abdulla S, Hoffman SL. PMID: 38194272; PMCID: PMC10940097.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    3. Treatments for COVID-19. Annu Rev Med. 2024 Jan 29; 75:145-157. Andrews HS, Herman JD, Gandhi RT. PMID: 37722709.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    4. Accumulation of Neutrophil Phagocytic Antibody Features Tracks With Naturally Acquired Immunity Against Malaria in Children. J Infect Dis. 2023 Sep 15; 228(6):759-768. Nziza N, Tran TM, DeRiso EA, Dolatshahi S, Herman JD, de Lacerda L, Junqueira C, Lieberman J, Ongoiba A, Doumbo S, Kayentao K, Traore B, Crompton PD, Alter G. PMID: 37150885; PMCID: PMC10503956.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    5. Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases. Sci Transl Med. 2023 Sep 06; 15(712):eadf6598. Herman JD, Atyeo C, Zur Y, Cook CE, Patel NJ, Vanni KM, Kowalski EN, Qian G, Srivatsan S, Shadick NA, Rao DA, Kellman B, Mann CJ, Lauffenburger D, Wallace ZS, Sparks JA, Alter G. PMID: 37672567; PMCID: PMC10764151.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsPHPublic Health
    6. Nucleocapsid-specific antibody function is associated with therapeutic benefits from COVID-19 convalescent plasma therapy. Cell Rep Med. 2022 Nov 15; 3(11):100811. Herman JD, Wang C, Burke JS, Zur Y, Compere H, Kang J, Macvicar R, Taylor S, Shin S, Frank I, Siegel D, Tebas P, Choi GH, Shaw PA, Yoon H, Pirofski LA, Julg BD, Bar KJ, Lauffenburger D, Alter G. PMID: 36351430; PMCID: PMC9595358.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    7. Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response. Nat Commun. 2021 Nov 25; 12(1):6853. Herman JD, Wang C, Loos C, Yoon H, Rivera J, Eugenia Dieterle M, Haslwanter D, Jangra RK, Bortz RH, Bar KJ, Julg B, Chandran K, Lauffenburger D, Pirofski LA, Alter G. PMID: 34824251; PMCID: PMC8617042.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    8. The Time is Now: A Call for Renewed Support of Infectious Diseases Physician-Scientist Trainees in the Era of Coronavirus Disease 2019. J Infect Dis. 2021 11 16; 224(9):1452-1454. Queen J, Karaba S, Albin J, Karaba A, Howard-Anderson J, Skinner N, Herman JD, Paras ML, Melia MT. PMID: 33770174; PMCID: PMC8083640.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling. ACS Infect Dis. 2019; 5(4):515-520. Fagbami, L., Deik, A. A., Singh, K., Santos, S. A., Herman, J. D., Bopp, S. E., Lukens, A. K., Clish, C. B., Wirth, D. F., and Mazitschek, R. View Publication.
    10. Genome Wide Association Studies of Drug-Resistance Determinants. Trends in Parasitology. 2017; 33(3):214-230. Volkman, S. K., Herman, J. D., Lukens, A. K., Hartl, D. L. View Publication.
    11. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20; 7(288):288ra77. Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R. PMID: 25995223; PMCID: PMC4675670.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    12. A genomic and evolutionary approach reveals non-genetic drug resistance in malaria. Genome Biol. 2014; 15(11):511. Herman JD, Rice DP, Ribacke U, Silterra J, Deik AA, Moss EL, Broadbent KM, Neafsey DE, Desai MM, Clish CB, Mazitschek R, Wirth DF. PMID: 25395010; PMCID: PMC4272547.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    13. Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proc Natl Acad Sci USA. 2013; 110(30):E2838-E2847. Hanson, K. K., Ressurreição, A. S., Buchholz, K., Prudêncio, M., Herman-Ornelas, J. D., Rebelo, M., Rebelo, M., Beatty, W. L., Wirth, D. F., Hänscheid, T., Moreira, R., Marti, M., Mota, M. M. View Publication.
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