Jonathan Lebowitz

Title(s)HS Assistant Clinical Professor, Pediatrics
SchoolMedicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Intracerebroventricular dosing of N-sulfoglucosamine sulfohydrolase in mucopolysaccharidosis IIIA mice reduces markers of brain lysosomal dysfunction. J Biol Chem. 2022 12; 298(12):102625. Magat J, Jones S, Baridon B, Agrawal V, Wong H, Giaramita A, Mangini L, Handyside B, Vitelli C, Parker M, Yeung N, Zhou Y, Pungor E, Slabodkin I, Gorostiza O, Aguilera A, Lo MJ, Alcozie S, Christianson TM, Tiger PMN, Vincelette J, Fong S, Gil G, Hague C, Lawrence R, Wendt DJ, Lebowitz JH, Bunting S, Bullens S, Crawford BE, Roy SM, Woloszynek JC. PMID: 36306823; PMCID: PMC9694393.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Identifying therapeutic drug targets using bidirectional effect genes. Nat Commun. 2021 04 13; 12(1):2224. Estrada K, Froelich S, Wuster A, Bauer CR, Sterling T, Clark WT, Ru Y, Trinidad M, Nguyen HP, Luu AR, Wendt DJ, Yogalingam G, Yu GK, LeBowitz JH, Cardon LR. PMID: 33850126; PMCID: PMC8044152.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    3. Correction: Intermittent enzyme replacement therapy prevents Neu1 deficiency. J Biol Chem. 2020 Nov 13; 295(46):15794. Luu AR, Wong C, Agrawal V, Wise N, Handyside B, Lo MJ, Pacheco G, Felix JB, Giaramita A, d'Azzo A, Vincelette J, Bullens S, Bunting S, Christianson TM, Hague CM, LeBowitz JH, Yogalingam G. PMID: 33188082; PMCID: PMC7667986.
      View in: PubMed   Mentions:    Fields:    
    4. Intermittent enzyme replacement therapy with recombinant human β-galactosidase prevents neuraminidase 1 deficiency J Biol Chem. 2020 09 25; 295(39):13556-13569. Luu AR, Wong C, Agrawal V, Wise N, Handyside B, Lo MJ, Pacheco G, Felix JB, Giaramita A, d'Azzo A, Vincelette J, Bullens S, Bunting S, Christianson TM, Hague CM, LeBowitz JH, Yogalingam G. PMID: 32727849; PMCID: PMC7521647.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    5. Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B. Drug Deliv Transl Res. 2020 04; 10(2):425-439. Grover A, Crippen-Harmon D, Nave L, Vincelette J, Wait JCM, Melton AC, Lawrence R, Brown JR, Webster KA, Yip BK, Baridon B, Vitelli C, Rigney S, Christianson TM, Tiger PMN, Lo MJ, Holtzinger J, Shaywitz AJ, Crawford BE, Fitzpatrick PA, LeBowitz JH, Bullens S, Aoyagi-Scharber M, Bunting S, O'Neill CA, Pinkstaff J, Bagri A. PMID: 31942701; PMCID: PMC7066106.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    6. Inhibition of endogenous miR-23a/miR-377 in CHO cells enhances difficult-to-express recombinant lysosomal sulfatase activity. Biotechnol Prog. 2020 05; 36(3):e2974. Amadi IM, Agrawal V, Christianson T, Bardliving C, Shamlou P, LeBowitz JH. PMID: 31990124.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. Characterization of glycan substrates accumulating in GM1 Gangliosidosis. Mol Genet Metab Rep. 2019 Dec; 21:100524. Lawrence R, Van Vleet JL, Mangini L, Harris A, Martin N, Clark W, Chandriani S, LeBowitz JH, Giugliani R, d'Azzo A, Yogalingam G, Crawford BE. PMID: 31720227; PMCID: PMC6838976.
      View in: PubMed   Mentions: 13  
    8. BMN 250, a fusion of lysosomal alpha-N-acetylglucosaminidase with IGF2, exhibits different patterns of cellular uptake into critical cell types of Sanfilippo syndrome B disease pathogenesis. PLoS One. 2019; 14(1):e0207836. Yogalingam G, Luu AR, Prill H, Lo MJ, Yip B, Holtzinger J, Christianson T, Aoyagi-Scharber M, Lawrence R, Crawford BE, LeBowitz JH. PMID: 30657762; PMCID: PMC6338363.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    9. Utilizing ExAC to assess the hidden contribution of variants of unknown significance to Sanfilippo Type B incidence. PLoS One. 2018; 13(7):e0200008. Clark WT, Yu GK, Aoyagi-Scharber M, LeBowitz JH. PMID: 29979746; PMCID: PMC6034809.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. Cellular Uptake and Delivery of Myeloperoxidase to Lysosomes Promote Lipofuscin Degradation and Lysosomal Stress in Retinal Cells. J Biol Chem. 2017 03 10; 292(10):4255-4265. Yogalingam G, Lee AR, Mackenzie DS, Maures TJ, Rafalko A, Prill H, Berguig GY, Hague C, Christianson T, Bell SM, LeBowitz JH. PMID: 28115520; PMCID: PMC5354499.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    11. Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14870-5. Kan SH, Aoyagi-Scharber M, Le SQ, Vincelette J, Ohmi K, Bullens S, Wendt DJ, Christianson TM, Tiger PM, Brown JR, Lawrence R, Yip BK, Holtzinger J, Bagri A, Crippen-Harmon D, Vondrak KN, Chen Z, Hague CM, Woloszynek JC, Cheung DS, Webster KA, Adintori EG, Lo MJ, Wong W, Fitzpatrick PA, LeBowitz JH, Crawford BE, Bunting S, Dickson PI, Neufeld EF. PMID: 25267636; PMCID: PMC4205671.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    12. Glycosylation-independent lysosomal targeting of acid α-glucosidase enhances muscle glycogen clearance in pompe mice. J Biol Chem. 2013 Jan 18; 288(3):1428-38. Maga JA, Zhou J, Kambampati R, Peng S, Wang X, Bohnsack RN, Thomm A, Golata S, Tom P, Dahms NM, Byrne BJ, LeBowitz JH. PMID: 23188827; PMCID: PMC3548456.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    13. Glycosylation-independent targeting enhances enzyme delivery to lysosomes and decreases storage in mucopolysaccharidosis type VII mice. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3083-8. LeBowitz JH, Grubb JH, Maga JA, Schmiel DH, Vogler C, Sly WS. PMID: 14976248; PMCID: PMC365748.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
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