Robert A Whittington

Title(s)Professor of Clinical , Anesthesiology
SchoolMedicine
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    Collapse Research 
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    Relationship between CNS Tau burden and perioperative neurocognitive disorder
    NIH R21AG067114Sep 1, 2020 - Aug 31, 2022
    Role: Co-Principal Investigator
    The Impact Of Surgery-Induced Neuroinflammation On Tau Pathology And Function
    NIH R01GM101698Sep 15, 2011 - Jul 31, 2020
    Role: Principal Investigator
    ANESTHESIA AND COCAINE INDUCED CNS EXCITOTOXICITY
    NIH K08GM000681Sep 1, 1999 - Aug 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Prospective Observational Cohort Study of Language Preference and Preoperative Cognitive Screening in Older Adults: Do Language Disparities Exist in Cognitive Screening and Does the Association Between Test Results and Postoperative Delirium Differ Based on Language Preference? Anesth Analg. 2024 Feb 07. Canales C, Ramirez CM, Yang SC, Feinberg SA, Grogan TR, Whittington RA, Sarkisian C, Cannesson M. PMID: 38324340.
      View in: PubMed   Mentions:    Fields:    
    2. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods Mol Biol. 2024; 2754:309-321. Fereydouni-Forouzandeh P, Canet G, Diego-Diàz S, Rocaboy E, Petry S, Whittington RA, Planel E. PMID: 38512673.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods Mol Biol. 2024; 2754:323-341. Canet G, Rocaboy E, Diego-Diàz S, Whittington RA, Julien C, Planel E. PMID: 38512674.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Temperature-induced Artifacts in Tau Phosphorylation: Implications for Reliable Alzheimer's Disease Research. Exp Neurobiol. 2023 Dec 31; 32(6):423-440. Canet G, Rocaboy E, Laliberté F, Boscher E, Guisle I, Diego-Diaz S, Fereydouni-Forouzandeh P, Whittington RA, Hébert SS, Pernet V, Planel E. PMID: 38196137; PMCID: PMC10789175.
      View in: PubMed   Mentions:
    5. Perspectives on Ethnic and Language Diversity in Perioperative Neurocognitive Disorders. Anesth Analg. 2023 10 01; 137(4):782-787. Canales C, Ibarra AJ, Burton BN, Cole DJ, Whittington R, Cannesson M. PMID: 37712470; PMCID: PMC10513730.
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    6. Pro-Con Debate: Judicious Benzodiazepine Administration for Preoperative Anxiolysis in Older Patients. Anesth Analg. 2023 08 01; 137(2):280-288. Mahanna-Gabrielli E, Schenning KJ, Deiner SG, Whittington RA. PMID: 37450906; PMCID: PMC10358369.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. A machine learning approach to identifying delirium from electronic health records. JAMIA Open. 2022 Jul; 5(2):ooac042. Kim JH, Hua M, Whittington RA, Lee J, Liu C, Ta CN, Marcantonio ER, Goldberg TE, Weng C. PMID: 35663114; PMCID: PMC9152701.
      View in: PubMed   Mentions: 3  
    8. Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia. Neurobiol Aging. 2022 05; 113:118-130. Guisle I, Canet G, Pétry S, Fereydouni-Forouzandeh P, Morin F, Kérauden R, Whittington RA, Calon F, Hébert SS, Planel E. PMID: 35334439.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. Prevalence of SARS-CoV-2 Positivity in Pediatric Surgical Patients Amid the First Wave of the COVID-19 Pandemic in New York City. J Neurosurg Anesthesiol. 2022 Jan 01; 34(1):132-135. Price JC, Lee JJ, Ing C, Li G, Narula J, Clark MK, Stylianos S, Whittington RA, Levy RJ, Sun LS. PMID: 34870636.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    10. The Anesthesiologist as Translational Scientist. J Neurosurg Anesthesiol. 2022 Jan 01; 34(1):113-115. Griffiths KK, Gerber A, Whittington RA. PMID: 34870632; PMCID: PMC8653981.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    11. COVID-19: A Catalyst for Transforming Randomized Trials. J Neurosurg Anesthesiol. 2022 Jan 01; 34(1):107-112. Lee JJ, Price JC, Jackson WM, Whittington RA, Ioannidis JPA. PMID: 34870631.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    12. Papper Event 2021: The COVID-19 Pandemic: Lessons Learned and the Way Forward. J Neurosurg Anesthesiol. 2022 01 01; 34(1):99-100. Sun LS, Brambrink A, Emala CW, Hua M, Lee HT, Levy RJ, Smiley RM, Whittington RA, Narula JH. PMID: 34870629.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    13. On the Importance of Language in Reports Discussing Racial Inequities. Anesth Analg. 2021 06 01; 132(6):e117-e118. Armstead V, Bucklin B, Bustillo M, Hastie MJ, Lane-Fall M, Lee A, Leffert L, Mackensen GB, Minhaj M, Sakai T, Straker T, Thenuwara K, Whitlock E, Whittington R, Wiener-Kronish J, Wong C. PMID: 34032683.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Relative potency of intravenous oxymorphone compared to other µ opioid agonists in humans - pilot study outcomes. Psychopharmacology (Berl). 2021 Sep; 238(9):2503-2514. Babalonis S, Comer SD, Jones JD, Nuzzo P, Lofwall MR, Manubay J, Hatton KW, Whittington RA, Walsh SL. PMID: 34106317; PMCID: PMC8514134.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Association of Delirium With Long-term Cognitive Decline: A Meta-analysis. JAMA Neurol. 2020 11 01; 77(11):1373-1381. Goldberg TE, Chen C, Wang Y, Jung E, Swanson A, Ing C, Garcia PS, Whittington RA, Moitra V. PMID: 32658246; PMCID: PMC7358977.
      View in: PubMed   Mentions: 112     Fields:    Translation:Humans
    16. The Frailty Syndrome: Anesthesiologists Must Understand More and Fear Less. Anesth Analg. 2020 06; 130(6):1445-1448. Whitlock EL, Whittington RA. PMID: 32384332; PMCID: PMC7678012.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Critical Illness and the Frailty Syndrome: Mechanisms and Potential Therapeutic Targets. Anesth Analg. 2020 06; 130(6):1545-1555. Paul JA, Whittington RA, Baldwin MR. PMID: 32384344; PMCID: PMC8415172.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    18. Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature. Sleep. 2020 04 15; 43(4). Guisle I, Gratuze M, Petry S, Morin F, Keraudren R, Whittington RA, Hébert SS, Mongrain V, Planel E. PMID: 31702011.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    19. Perioperative Neurocognitive Disorder: State of the Preclinical Science. Anesthesiology. 2020 01; 132(1):55-68. Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, Wei H, Whittington RA, Terrando N, Orser BA, Eckenhoff MF. PMID: 31834869; PMCID: PMC6913778.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    20. Corrigendum to 'State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018' (Br J Anaesth 2019; 123: 464-478). Br J Anaesth. 2019 12; 123(6):917. Mahanna-Gabrielli E, Schenning KJ, Eriksson LI, Browndyke JN, Wright CB, Culley DJ, Evered L, Scott DA, Wang NY, Brown CH, Oh E, Purdon P, Inouye S, Berger M, Whittington RA, Price CC, Deiner S. PMID: 31591017; PMCID: PMC6883482.
      View in: PubMed   Mentions:    Fields:    
    21. In Response. Anesth Analg. 2019 09; 129(3):e112-e113. Berger M, Angst MS, Culley DJ, Price CE, Scott DA, Whittington RA, Eckenhoff RG, Perioperative Neurotoxicity Working Group. PMID: 31425253; PMCID: PMC7153730.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018. Br J Anaesth. 2019 10; 123(4):464-478. Mahanna-Gabrielli E, Schenning KJ, Eriksson LI, Browndyke JN, Wright CB, Culley DJ, Evered L, Scott DA, Wang NY, Brown CH, Oh E, Purdon P, Inouye S, Berger M, Whittington RA, Price CC, Deiner S. PMID: 31439308; PMCID: PMC6871269.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    23. Aging Gracefully: The Evolution of Perioperative Care for Older Adults. Anesthesiol Clin. 2019 Sep; 37(3):xv-xvi. Whitlock EL, Whittington RA. PMID: 31337489.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Anesth Analg. 2018 12; 127(6):1406-1413. Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z, Perioperative Neurotoxicity Working Group. PMID: 30303868; PMCID: PMC6309612.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
    25. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiol Aging. 2019 03; 75:11-24. Whittington RA, Virág L, Gratuze M, Lewkowitz-Shpuntoff H, Cheheltanan M, Petry F, Poitras I, Morin F, Planel E. PMID: 30508732; PMCID: PMC6349516.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    26. The Pros of Publishing Standalone Clinical Trial Protocols in Anesthesiology Journals. Anesth Analg. 2018 05; 126(5):1441-1443. Whittington RA. PMID: 29672381.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Impaired Resolution of Inflammation in Alzheimer's Disease: A Review. Front Immunol. 2017; 8:1464. Whittington RA, Planel E, Terrando N. PMID: 29163531; PMCID: PMC5681480.
      View in: PubMed   Mentions: 34     Fields:    
    28. Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease. Neurobiol Dis. 2017 Feb; 98:1-8. Gratuze M, El Khoury NB, Turgeon A, Julien C, Marcouiller F, Morin F, Whittington RA, Marette A, Calon F, Planel E. PMID: 27793638.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    29. Physical Activity and Cognitive Development: A Meta-Analysis. J Neurosurg Anesthesiol. 2016 Oct; 28(4):373-380. Jackson WM, Davis N, Sands SA, Whittington RA, Sun LS. PMID: 27768674.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    30. Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors. J Neurosci. 2015 Sep 02; 35(35):12217-31. Hipólito L, Wilson-Poe A, Campos-Jurado Y, Zhong E, Gonzalez-Romero J, Virag L, Whittington R, Comer SD, Carlton SM, Walker BM, Bruchas MR, Morón JA. PMID: 26338332; PMCID: PMC4556787.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    31. Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro. Neurobiol Aging. 2015 Aug; 36(8):2414-28. Whittington RA, Virág L, Gratuze M, Petry FR, Noël A, Poitras I, Truchetti G, Marcouiller F, Papon MA, El Khoury N, Wong K, Bretteville A, Morin F, Planel E. PMID: 26058840; PMCID: PMC4465078.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    32. Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease. Hum Mol Genet. 2015 Jan 01; 24(1):86-99. Gratuze M, Noël A, Julien C, Cisbani G, Milot-Rousseau P, Morin F, Dickler M, Goupil C, Bezeau F, Poitras I, Bissonnette S, Whittington RA, Hébert SS, Cicchetti F, Parker JA, Samadi P, Planel E. PMID: 25205109.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    33. Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions. PLoS One. 2014; 9(5):e94251. Petry FR, Pelletier J, Bretteville A, Morin F, Calon F, Hébert SS, Whittington RA, Planel E. PMID: 24788298; PMCID: PMC4008431.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    34. Specifying the non-specific factors underlying opioid analgesia: expectancy, attention, and affect. Psychopharmacology (Berl). 2014 Mar; 231(5):813-23. Atlas LY, Wielgosz J, Whittington RA, Wager TD. PMID: 24096537; PMCID: PMC3945427.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    35. Oral choline supplementation for postoperative pain. Br J Anaesth. 2013 Aug; 111(2):249-55. Sidhu N, Davies S, Nadarajah A, Rivera J, Whittington R, Mercier RJ, Virag L, Wang S, Flood P. PMID: 23568851; PMCID: PMC3841409.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Anesthesia and tau pathology. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 02; 47:147-55. Whittington RA, Bretteville A, Dickler MF, Planel E. PMID: 23535147; PMCID: PMC3741335.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    37. Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation. Sci Rep. 2013; 3:1388. Whittington RA, Bretteville A, Virág L, Emala CW, Maurin TO, Marcouiller F, Julien C, Petry FR, El-Khoury NB, Morin F, Charron J, Planel E. PMID: 24045785; PMCID: PMC3965357.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    38. Dissociable influences of opiates and expectations on pain. J Neurosci. 2012 Jun 06; 32(23):8053-64. Atlas LY, Whittington RA, Lindquist MA, Wielgosz J, Sonty N, Wager TD. PMID: 22674280; PMCID: PMC3387557.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    39. Alzheimer's disease and anesthesia. Front Neurosci. 2011; 4:272. Papon MA, Whittington RA, El-Khoury NB, Planel E. PMID: 21344011; PMCID: PMC3034231.
      View in: PubMed   Mentions: 31  
    40. Propofol directly increases tau phosphorylation. PLoS One. 2011 Jan 31; 6(1):e16648. Whittington RA, Virág L, Marcouiller F, Papon MA, El Khoury NB, Julien C, Morin F, Emala CW, Planel E. PMID: 21304998; PMCID: PMC3031597.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    41. Hypothermia and Alzheimer's disease neuropathogenic pathways. Curr Alzheimer Res. 2010 Dec; 7(8):717-25. Whittington RA, Papon MA, Chouinard F, Planel E. PMID: 20678067.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    42. Psychiatric wards: places of safety? J Psychiatr Ment Health Nurs. 2010 Mar; 17(2):124-30. Jones J, Nolan P, Bowers L, Simpson A, Whittington R, Hackney D, Bhui K. PMID: 20465757.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    43. The differential effects of equipotent doses of isoflurane and desflurane on hippocampal acetylcholine levels in young and aged rats. Neurosci Lett. 2010 Mar 08; 471(3):166-70. Whittington RA, Virág L. PMID: 20097265.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    44. Comparison of the effects of sevoflurane and isoflurane anesthesia on the maternal-fetal unit in sheep. J Anesth. 2009; 23(3):392-8. Okutomi T, Whittington RA, Stein DJ, Morishima HO. PMID: 19685120.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    45. Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease. Anesth Analg. 2009 May; 108(5):1627-30. Baranov D, Bickler PE, Crosby GJ, Culley DJ, Eckenhoff MF, Eckenhoff RG, Hogan KJ, Jevtovic-Todorovic V, Palotás A, Perouansky M, Planel E, Silverstein JH, Wei H, Whittington RA, Xie Z, Zuo Z, First International Workshop on Anesthetics and Alzheimer's Disease. PMID: 19372347; PMCID: PMC2769511.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    46. Endogenous gamma-aminobutyric acid modulates tonic guinea pig airway tone and propofol-induced airway smooth muscle relaxation. Anesthesiology. 2009 Apr; 110(4):748-58. Gallos G, Gleason NR, Virag L, Zhang Y, Mizuta K, Whittington RA, Emala CW. PMID: 19322939; PMCID: PMC3608685.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    47. Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. FASEB J. 2009 Aug; 23(8):2595-604. Planel E, Bretteville A, Liu L, Virag L, Du AL, Yu WH, Dickson DW, Whittington RA, Duff KE. PMID: 19279139; PMCID: PMC2717763.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    48. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci. 2008 Nov 26; 28(48):12798-807. Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE. PMID: 19036972; PMCID: PMC2610528.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    49. Sudden amnesia resulting in pain relief: the relationship between memory and pain. Pain. 2007 Nov; 132(1-2):206-10. Choi DS, Choi DY, Whittington RA, Nedeljkovic SS. PMID: 17764843.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    50. Abuse liability of prescription opioids compared to heroin in morphine-maintained heroin abusers. Neuropsychopharmacology. 2008 Apr; 33(5):1179-91. Comer SD, Sullivan MA, Whittington RA, Vosburg SK, Kowalczyk WJ. PMID: 17581533; PMCID: PMC3787689.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCTClinical Trials
    51. Isoflurane decreases extracellular serotonin in the mouse hippocampus. Anesth Analg. 2006 Jul; 103(1):92-8, table of contents. Whittington RA, Virág L. PMID: 16790633.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    52. Dexmedetomidine-induced decreases in accumbal dopamine in the rat are partly mediated via the locus coeruleus. Anesth Analg. 2006 Feb; 102(2):448-55. Whittington RA, Virág L. PMID: 16428541.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    53. Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial. JAMA. 2005 Aug 24; 294(8):903-13. Collins ED, Kleber HD, Whittington RA, Heitler NE. PMID: 16118380.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCTClinical Trials
    54. Dexmedetomidine increases the cocaine seizure threshold in rats. Anesthesiology. 2002 Sep; 97(3):693-700. Whittington RA, Virag L, Vulliemoz Y, Cooper TB, Morishima HO. PMID: 12218537.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    55. Highly sensitive chromatographic assay for dopamine determination during in vivo cerebral microdialysis in the rat. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Jun 05; 772(2):267-72. Virag L, Whittington RA. PMID: 12007771.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    56. Predicting prostate specific antigen outcome preoperatively in the prostate specific antigen era. J Urol. 2001 Dec; 166(6):2185-8. D'Amico AV, Whittington R, Malkowicz SB, Weinstein M, Tomaszewski JE, Schultz D, Rhude M, Rocha S, Wein A, Richie JP. PMID: 11696732.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    57. Estimating the impact on prostate cancer mortality of incorporating prostate-specific antigen testing into screening. Urology. 2001 Sep; 58(3):406-10. D'Amico AV, Whittington R, Malkowicz SB, Renshaw AA, Tomaszewski JE, Bentley C, Schultz D, Rocha S, Wein A, Richie JP. PMID: 11549489.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    58. Dose-related differences in the distribution of cocaine in the maternal-fetoplacental compartments in rats. Neurotoxicol Teratol. 2000 Nov-Dec; 22(6):837-44. Morishima HO, Okutomi T, Whittington RA, Cooper TB. PMID: 11120389.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    59. Rapid opioid detoxification during general anesthesia: is death not a significant outcome? Anesthesiology. 2000 Nov; 93(5):1363-4. Whittington RA, Collins ED, Kleber HD. PMID: 11046233.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    60. Disposition of bupivacaine and its metabolites in the maternal, placental, and fetal compartments in rats. Anesthesiology. 2000 Oct; 93(4):1069-74. Morishima HO, Ishizaki A, Zhang Y, Whittington RA, Suckow RF, Cooper TB. PMID: 11020763.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    61. Utilizing predictions of early prostate-specific antigen failure to optimize patient selection for adjuvant systemic therapy trials. J Clin Oncol. 2000 Sep 15; 18(18):3240-6. D'Amico AV, Whittington R, Malkowicz SB, Wu YH, Chen MH, Hurwitz M, Kantoff PW, Tomaszewski JE, Renshaw AA, Wein A, Richie JP. PMID: 10986056.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    62. Endorectal magnetic resonance imaging as a predictor of biochemical outcome after radical prostatectomy in men with clinically localized prostate cancer. J Urol. 2000 Sep; 164(3 Pt 1):759-63. D'Amico AV, Whittington R, Malkowicz B, Schnall M, Schultz D, Cote K, Tomaszewski JE, Wein A. PMID: 10953141.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    63. Outcome of pancreaticoduodenectomy and impact of adjuvant therapy for ampullary carcinomas. Int J Radiat Oncol Biol Phys. 2000 Jul 01; 47(4):945-53. Lee JH, Whittington R, Williams NN, Berry MF, Vaughn DJ, Haller DG, Rosato EF. PMID: 10863064.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    64. Prostate specific antigen outcome based on the extent of extracapsular extension and margin status in patients with seminal vesicle negative prostate carcinoma of Gleason score < or = 7. Cancer. 2000 May 01; 88(9):2110-5. D'Amico AV, Whittington R, Malkowicz SB, Schultz D, Tomaszewski JE, Wein A. PMID: 10813723.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    65. Combination of the preoperative PSA level, biopsy gleason score, percentage of positive biopsies, and MRI T-stage to predict early PSA failure in men with clinically localized prostate cancer. Urology. 2000 Apr; 55(4):572-7. D'Amico AV, Whittington R, Malkowicz SB, Wu YH, Chen M, Art M, Tomaszewski JE, Wein A. PMID: 10736506.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    66. The nitric oxide-cGMP system of the locus coeruleus and the hypnotic action of alpha-2 adrenergic agonists. Brain Res. 1999 Dec 04; 849(1-2):169-74. Vulliemoz Y, Whittington RA, Virag L. PMID: 10592299.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    67. Role of gender in the toxicity of norcocaine. J Lab Clin Med. 1999 Jun; 133(6):590-6. Whittington RA, Iso A, Khan K, Cooper TB, Morishima HO. PMID: 10360634.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    68. The comparative toxicity of cocaine and its metabolites in conscious rats. Anesthesiology. 1999 Jun; 90(6):1684-90. Morishima HO, Whittington RA, Iso A, Cooper TB. PMID: 10360867.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    69. The disposition of cocaethylene in rat maternal, placental, and fetal compartments. Am J Obstet Gynecol. 1999 May; 180(5):1289-96. Morishima HO, Whittington RA, Zhang Y, Cooper TB. PMID: 10329892.
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    70. Pretreatment nomogram for prostate-specific antigen recurrence after radical prostatectomy or external-beam radiation therapy for clinically localized prostate cancer. J Clin Oncol. 1999 Jan; 17(1):168-72. D'Amico AV, Whittington R, Malkowicz SB, Fondurulia J, Chen MH, Kaplan I, Beard CJ, Tomaszewski JE, Renshaw AA, Wein A, Coleman CN. PMID: 10458230.
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    71. Interaction of the alpha-2 adrenergic- and opioid receptor with the cGMP system in the mouse cerebellum. Brain Res. 1998 Nov 30; 813(1):26-31. Vulliemoz Y, Virag L, Whittington RA. PMID: 9824660.
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    72. Pharmacokinetic considerations for the use of the ovine model in cocaine research. Anesthesiology. 1997 Mar; 86(3):746-7. Morishima HO, Whittington RA. PMID: 9066344.
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    73. Sodium nitroprusside metabolism in children. Anesth Analg. 1996 Jun; 82(6):1301-2. Kazim R, Whittington RA, Sun LS. PMID: 8638813.
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    74. Species-, gender-, and pregnancy-related differences in the pharmacokinetics and pharmacodynamics of cocaine. NIDA Res Monogr. 1995; 158:2-21. Morishima HO, Whittington RA. PMID: 8594485.
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    75. A comparison of preoperative radiotherapy regimens for bladder carcinoma. The University of Pennsylvania experience. Cancer. 1988 Jan 15; 61(2):255-62. Spera JA, Whittington R, Littman P, Solin LJ, Wein AJ. PMID: 3334959.
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