Bishuang Cai

Title(s)Associate Professor-in-residence, Medicine
SchoolMedicine
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    Disturbed Crosstalk between Cholesterol Homeostasis and Inflammation Resolution in NASH
    NIH R01DK134610May 1, 2023 - Apr 30, 2027
    Role: Principal Investigator
    EHD1-mediated Inflammation and Resolution in Atherosclerosis
    NIH R01HL167107May 1, 2023 - Apr 30, 2027
    Role: Principal Investigator
    Efferocytosis meets endocytosis
    NIH R35GM147269Aug 1, 2022 - Jun 30, 2027
    Role: Principal Investigator
    MerTK in NASH-related liver fibrosis
    NIH R00DK115778Jul 16, 2020 - Apr 30, 2023
    Role: Principal Investigator
    MerTK in NASH-related liver fibrosis
    NIH K99DK115778Jul 16, 2018 - Jul 15, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting lipidated amino acid deficiency mitigates fibrosis via a PPARα/CCL2 axis in metabolic dysfunction-associated steatohepatitis models. J Clin Invest. 2026 Sep 24. Anand SK, Das S, Arias F, Richard KS, Rohilla S, Ghrayeb A, McKinney MP, Wang L, Tan L, Ding J, Kumar D, Pandey N, Lee J, Zhao Y, Mohajan S, Male G, Nunez K, Finney AC, Pearson-Gallion BH, Gade R, Maxie J, Liu Y, Kaur H, Pandit R, Ben Dhaou C, Eniafe J, Zhang X, Liu Z, Yurochko AD, Garcia-Barrio MT, Razani B, Chang F, Schopfer FJ, Huang X, Cai B, Gottlieb E, Wen B, Sun D, Liu W, Thevenot PT, Cohen AJ, Zhang J, Chen YE, Orr AW, Dhanesha N, Yurdagul A, Rom O. PMID: 42784330.
      View in: PubMed   Mentions:
    2. Hepatic stellate cell subpopulations in human MASLD-related hepatocellular carcinoma upregulate YAP via geranylgeranyl pyrophosphate. Hepatol Commun. 2026 Sep 01; 10(9). Labrecque CL, Ko A, Qiao B, Pan C, Nandakumar R, Chowdhury K, Venkatesan N, Du X, Cai B, Pellegrini M, Pisegna JR, French SW, Agopian V, Rozengurt E, Singh R, Benhammou JN. PMID: 42612117; PMCID: PMC13480919.
      View in: PubMed   Mentions:
    3. Sexual dimorphism in the association of circulating TAM receptors-ligands with MASLD-related fibrosis. JHEP Rep. 2026 Sep; 8(9):101937. Zhu Y, Gupta N, Cogliati B, He Y, Leviton A, Benhammou JN, Han SB, Zhou Z, Nguyen A, Zhang X, Singh R, Friedman SL, Bansal MB, Cai B. PMID: 42379304; PMCID: PMC13521018.
      View in: PubMed   Mentions:
    4. Macrophage EHD1 Promotes Inflammation and Stabilizes Sortilin to Accelerate Atherosclerosis. Circ Res. 2026 Jun 19; 139(1):e327751. Ma F, Liu Y, Xu Y, Liu W, Gupta N, Zhu Y, Xiao L, Swee S, Adam I, Zheng E, Ping P, Traylor JG, Rom O, Kovacic JC, Fidler TP, Yurdagul A, Singh R, Orr AW, Huang X, Cai B. PMID: 42165151; PMCID: PMC13196443.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. From lipoprotein metabolism to blood clotting: Highlights of the 2025 Fredrickson lipid research conference. J Lipid Res. 2026 05; 67(5):101041. Smith AN, Beg MA, Hur WS, Ginsburg D, Kullo IJ, Davies SS, Tabas I, Williams JW, Mineo C, Cai B, Gupta RK, Amengual J, Schwendeman A, Graf GA, Sorci Thomas M, Zheng Z. PMID: 41999980; PMCID: PMC13196529.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. Macrophage efferocytosis in cardiovascular disease: mechanisms and therapeutic implications. Immunohorizons. 2026 Feb 17; 10(SI). Gupta N, Liu Y, Cai B. PMID: 41774843; PMCID: PMC12955849.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Sex-based multiomics analysis uncovers metabolic and molecular mediators linking MASH and atherosclerosis. JHEP Rep. 2026 Mar; 8(3):101703. Das S, Anand SK, McKinney MP, Richard KSE, Mahmud I, Rohilla S, Arias F, Ghrayeb A, Wei B, Tan L, Liu Z, Kumar D, Finney AC, Pandey N, Kaur H, Pandit R, Zhang X, Ben Dhaou C, Thayer SP, Razani B, Cai B, Chang F, Schopfer FJ, Liu W, Fisher EA, Radhakrishnan S, Gottlieb E, Orr AW, Dhanesha N, Yurdagul A, Lorenzi PL, Rom O. PMID: 41777553; PMCID: PMC12950431.
      View in: PubMed   Mentions:
    8. Macrophage EHD1 promotes inflammation and stabilizes sortilin to accelerate atherosclerosis. bioRxiv. 2025 Oct 28. Ma F, Liu Y, Xu Y, Liu W, Gupta N, Zhu Y, Xiao L, Traylor JG, Rom O, Kovacic JC, Fidler TP, Yurdagul A, Orr AW, Huang X, Cai B. PMID: 41279772; PMCID: PMC12636584.
      View in: PubMed   Mentions:
    9. Mechanisms and therapeutic insights into MASH-associated fibrosis. Trends Endocrinol Metab. 2026 May; 37(5):402-417. Zhu Y, Cai B. PMID: 41015698; PMCID: PMC12958455.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    10. Protocol for detecting LDLR on the cell surface of primary mouse hepatocytes using cell-surface biotinylation. STAR Protoc. 2025 Sep 19; 6(3):103977. Ma F, Cai B. PMID: 40705595; PMCID: PMC12305577.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Resolvin D1-mediated cellular crosstalk protects against MASH. JHEP Rep. 2025 Aug; 7(8):101454. Navarro-Corcuera A, Zhu Y, Ma F, Gupta N, Asplund H, Cogliati B, Chipuk JE, Rom O, Friedman SL, Sansbury BE, Huang X, Cai B. PMID: 40671835; PMCID: PMC12260426.
      View in: PubMed   Mentions: 1  
    12. EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis. Cell Metab. 2025 May 06; 37(5):1152-1170.e7. Ma F, Longo M, Meroni M, Bhattacharya D, Paolini E, Mughal S, Hussain S, Anand SK, Gupta N, Zhu Y, Navarro-Corcuera A, Li K, Prakash S, Cogliati B, Wang S, Huang X, Wang X, Yurdagul A, Rom O, Wang L, Fried SK, Dongiovanni P, Friedman SL, Cai B. PMID: 40015280; PMCID: PMC12058419.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    13. Serum albumin: a potential biomarker for liver involvement in SARS-CoV-2 infection. EBioMedicine. 2025 Feb; 112:105565. Gupta N, Cai B. PMID: 39864129; PMCID: PMC11873546.
      View in: PubMed   Mentions:    Fields:    
    14. Therapeutic Activity of Resolvin D1 (RvD1) in Murine MASH. bioRxiv. 2024 Apr 26. Navarro-Corcuera A, Zhu Y, Ma F, Gupta N, Asplund H, Yuan F, Friedman S, Sansbury BE, Huang X, Cai B. PMID: 38712196; PMCID: PMC11071427.
      View in: PubMed   Mentions:
    15. Retinal atrophy, inflammation, phagocytic and metabolic disruptions develop in the MerTK-cleavage-resistant mouse model. Front Neurosci. 2024; 18:1256522. Enderlin J, Rieu Q, Réty S, Vanoni EM, Roux S, Dégardin J, César Q, Augustin S, Nous C, Cai B, Fontaine V, Sennlaub F, Nandrot EF. PMID: 38680449; PMCID: PMC11047123.
      View in: PubMed   Mentions: 1  
    16. Linking MASLD to ACVD through Kupffer cells. Nat Cardiovasc Res. 2024 03; 3(3):258-259. Ma F, Huang X, Cai B. PMID: 39196120.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Roles of Activin A and Gpnmb in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Diabetes. 2024 Feb 01; 73(2):260-279. Liu H, Yerevanian A, Westerhoff M, Hastings MH, Guerra JRB, Zhao M, Svensson KJ, Cai B, Soukas AA, Rosenzweig A. PMID: 37934943; PMCID: PMC10796305.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    18. ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1. Dev Cell. 2024 02 26; 59(4):465-481.e6. Huang X, Balmer S, Lyu C, Xiang Y, Malik V, Wang H, Zhang Y, Cai B, Xie W, Hadjantonakis AK, Zhou H, Wang J. PMID: 38237590; PMCID: PMC10923053.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    19. The interplay between nonalcoholic fatty liver disease and atherosclerotic cardiovascular disease. Front Cardiovasc Med. 2023; 10:1116861. Finney AC, Das S, Kumar D, McKinney MP, Cai B, Yurdagul A, Rom O. PMID: 37200978; PMCID: PMC10185914.
      View in: PubMed   Mentions: 22  
    20. Hepatocyte SREBP signaling mediates clock communication within the liver. J Clin Invest. 2023 04 17; 133(8). Guan D, Bae H, Zhou D, Chen Y, Jiang C, La CM, Xiao Y, Zhu K, Hu W, Trinh TM, Liu P, Xiong Y, Cai B, Jang C, Lazar MA. PMID: 37066875; PMCID: PMC10104893.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    21. PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2023 01; 43(1):30-44. Zahr T, Liu L, Chan M, Zhou Q, Cai B, He Y, Aaron N, Accili D, Sun L, Qiang L. PMID: 36453279; PMCID: PMC9917767.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    22. CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis. Sci Transl Med. 2022 11 23; 14(672):eabp8309. Shi H, Wang X, Li F, Gerlach BD, Yurdagul A, Moore MP, Zeldin S, Zhang H, Cai B, Zheng Z, Valenti L, Tabas I. PMID: 36417485; PMCID: PMC10199725.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    23. Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution. Nat Metab. 2022 04; 4(4):444-457. Ampomah PB, Cai B, Sukka SR, Gerlach BD, Yurdagul A, Wang X, Kuriakose G, Darville LNF, Sun Y, Sidoli S, Koomen JM, Tall AR, Tabas I. PMID: 35361955; PMCID: PMC9050866.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    24. MerTK, a risk factor for NASH fibrosis. Aging (Albany NY). 2020 10 27; 12(20):19832-19833. Wang X, Cai B. PMID: 33125345; PMCID: PMC7655196.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Liver cholesterol matters. Aging (Albany NY). 2020 10 26; 12(20):19828-19829. Cai B, Wang X. PMID: 33125343; PMCID: PMC7655184.
      View in: PubMed   Mentions:    Fields:    
    26. TAM receptors and their ligand-mediated activation: Role in atherosclerosis. Int Rev Cell Mol Biol. 2020; 357:21-33. Cai B, Kasikara C. PMID: 33234243; PMCID: PMC7971185.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    27. Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. Cell Metab. 2020 02 04; 31(2):406-421.e7. Cai B, Dongiovanni P, Corey KE, Wang X, Shmarakov IO, Zheng Z, Kasikara C, Davra V, Meroni M, Chung RT, Rothlin CV, Schwabe RF, Blaner WS, Birge RB, Valenti L, Tabas I. PMID: 31839486; PMCID: PMC7004886.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    28. A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice. Hepatol Commun. 2019 Sep; 3(9):1221-1234. Wang X, Sommerfeld MR, Jahn-Hofmann K, Cai B, Filliol A, Remotti HE, Schwabe RF, Kannt A, Tabas I. PMID: 31497743; PMCID: PMC6719739.
      View in: PubMed   Mentions: 37     Fields:    
    29. An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1. Blood. 2019 02 14; 133(7):743-753. Zheng Z, Nayak L, Wang W, Yurdagul A, Wang X, Cai B, Lapping S, Ozcan L, Ramakrishnan R, Pestell RG, Jain MK, Tabas I. PMID: 30504459; PMCID: PMC6376283.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    30. Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice. Circ Res. 2018 11 09; 123(11):e35-e47. Wang W, Liu W, Fidler T, Wang Y, Tang Y, Woods B, Welch C, Cai B, Silvestre-Roig C, Ai D, Yang YG, Hidalgo A, Soehnlein O, Tabas I, Levine RL, Tall AR, Wang N. PMID: 30571460; PMCID: PMC6309796.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    31. MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity. Sci Signal. 2018 09 25; 11(549). Cai B, Kasikara C, Doran AC, Ramakrishnan R, Birge RB, Tabas I. PMID: 30254055; PMCID: PMC6171110.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    32. The role of non-resolving inflammation in atherosclerosis. J Clin Invest. 2018 07 02; 128(7):2713-2723. Kasikara C, Doran AC, Cai B, Tabas I. PMID: 30108191; PMCID: PMC6025992.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    33. Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis. Front Cardiovasc Med. 2017; 4:86. Yurdagul A, Doran AC, Cai B, Fredman G, Tabas IA. PMID: 29379788; PMCID: PMC5770804.
      View in: PubMed   Mentions: 167  
    34. CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis. J Clin Invest. 2017 Nov 01; 127(11):4075-4089. Doran AC, Ozcan L, Cai B, Zheng Z, Fredman G, Rymond CC, Dorweiler B, Sluimer JC, Hsieh J, Kuriakose G, Tall AR, Tabas I. PMID: 28972541; PMCID: PMC5663361.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    35. Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages. Cell. 2017 Oct 05; 171(2):331-345.e22. Wang Y, Subramanian M, Yurdagul A, Barbosa-Lorenzi VC, Cai B, de Juan-Sanz J, Ryan TA, Nomura M, Maxfield FR, Tabas I. PMID: 28942921; PMCID: PMC5679712.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansAnimalsCells
    36. Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis. Cell Metab. 2016 12 13; 24(6):848-862. Wang X, Zheng Z, Caviglia JM, Corey KE, Herfel TM, Cai B, Masia R, Chung RT, Lefkowitch JH, Schwabe RF, Tabas I. PMID: 28068223; PMCID: PMC5226184.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansAnimalsCells
    37. MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):6526-31. Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin CS, Spite M, Fredman G, Tabas I. PMID: 27199481; PMCID: PMC4988577.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
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