Bruce Kagan

Title(s)	Professor of Clinical , Psychiatry and Biobehavioral Sciences
School	Medicine
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Research

Research Activities and Funding

BEHAVIORAL DISORDERS AND TNF CHANNELS IN AIDS
NIH K02MH001174Jan 1, 1994 - Dec 31, 1999
Role: Principal Investigator

GATING AND TRANSLOCATION IN THE DIPHTHERIA TOXIN CHANNEL
NIH R29MH043433May 1, 1988 - Apr 30, 1993
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Bipolar spectrum disorder masquerading as treatment resistant unipolar depression. CNS Spectr. 2022 02; 27(1):4-6. Fogelson DL, Kagan BL. PMID: 33267921.

View in: PubMed Mentions: Fields:
Neu Neurology Psy Psychiatry
Translation:Humans
Effect of screening, brief intervention and referral to treatment for unhealthy alcohol and other drug use in mental health treatment settings: a randomized controlled trial. Addiction. 2021 01; 116(1):159-169. Karno MP, Rawson R, Rogers B, Spear S, Grella C, Mooney LJ, Saitz R, Kagan B, Glasner S. PMID: 32415721; PMCID: PMC7666646.

View in: PubMed Mentions: 4 Fields:
Sub Substance-Related Disorders
Translation:Humans PHPublic Health
Ion channel formation by N-terminally truncated Aβ (4-42): relevance for the pathogenesis of Alzheimer's disease. Nanomedicine. 2020 10; 29:102235. Karkisaval AG, Rostagno A, Azimov R, Ban DK, Ghiso J, Kagan BL, Lal R. PMID: 32531337; PMCID: PMC8132454.

View in: PubMed Mentions: 6 Fields:
Bio Biotechnology Nan Nanotechnology
Translation:Humans Cells
Preliminary Outcomes of a Computerized CBT/MET Intervention for Depressed Cannabis Users in Psychiatry Care. Cannabis. 2018; 1(2):36-47. Glasner S, Kay-Lambkin F, Budney AJ, Gitlin M, Kagan B, Chokron-Garneau H, Ang A, Venegas A. PMID: 31840135; PMCID: PMC6910653.

View in: PubMed Mentions: 1
Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts. ACS Chem Neurosci. 2017 06 21; 8(6):1348-1357. Lee J, Kim YH, T Arce F, Gillman AL, Jang H, Kagan BL, Nussinov R, Yang J, Lal R. PMID: 28135799; PMCID: PMC6197823.

View in: PubMed Mentions: 30 Fields:
Neu Neurology
Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels. Methods Mol Biol. 2016; 1345:251-68. Jang H, Arce FT, Lee J, Gillman AL, Ramachandran S, Kagan BL, Lal R, Nussinov R. PMID: 26453217; PMCID: PMC7511997.

View in: PubMed Mentions: 4 Fields:
Mol Molecular Biology
Translation:Humans Cells
Ion Channel Formation by Tau Protein: Implications for Alzheimer's Disease and Tauopathies. Biochemistry. 2015 Dec 22; 54(50):7320-5. Patel N, Ramachandran S, Azimov R, Kagan BL, Lal R. PMID: 26575330; PMCID: PMC4690196.

View in: PubMed Mentions: 22 Fields:
Bio Biochemistry
Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs. Chem Soc Rev. 2014 Oct 07; 43(19):6750-64. Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. PMID: 24566672; PMCID: PMC4143503.

View in: PubMed Mentions: 39 Fields:
Che Chemistry
Translation:Humans Cells
Role of the fast kinetics of pyroglutamate-modified amyloid-β oligomers in membrane binding and membrane permeability. Biochemistry. 2014 Jul 22; 53(28):4704-14. Lee J, Gillman AL, Jang H, Ramachandran S, Kagan BL, Nussinov R, Teran Arce F. PMID: 24950761; PMCID: PMC4215883.

View in: PubMed Mentions: 25 Fields:
Bio Biochemistry
Translation:Humans Cells
Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores. J Phys Chem B. 2014 Jul 03; 118(26):7335-44. Gillman AL, Jang H, Lee J, Ramachandran S, Kagan BL, Nussinov R, Teran Arce F. PMID: 24922585; PMCID: PMC4096221.

View in: PubMed Mentions: 22 Fields:
Che Chemistry
Translation:Cells
Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment. J Phys Chem B. 2013 Oct 03; 117(39):11518-29. Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. PMID: 24000923; PMCID: PMC3946471.

View in: PubMed Mentions: 20 Fields:
Che Chemistry
Translation:Humans Cells
Alzheimer's disease: which type of amyloid-preventing drug agents to employ? Phys Chem Chem Phys. 2013 Jun 21; 15(23):8868-77. Jang H, Connelly L, Arce FT, Ramachandran S, Lal R, Kagan BL, Nussinov R. PMID: 23450150; PMCID: PMC3663909.

View in: PubMed Mentions: 21 Fields:
Bio Biophysics Che Chemistry Phy Physics
Translation:Humans Animals
Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane. J Chem Theory Comput. 2013 Jan 08; 9(1):822-833. Jang H, Connelly L, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. PMID: 23316126; PMCID: PMC3539805.

View in: PubMed Mentions: 59 Fields:
Bio Biochemistry Che Chemistry
Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations. Biochemistry. 2012 Apr 10; 51(14):3031-8. Connelly L, Jang H, Arce FT, Ramachandran S, Kagan BL, Nussinov R, Lal R. PMID: 22413858; PMCID: PMC7512688.

View in: PubMed Mentions: 29 Fields:
Bio Biochemistry
Translation:Cells
All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers. J Chem Theory Comput. 2012 Mar 13; 8(3):1143-1152. Capone R, Jang H, Kotler SA, Connelly L, Teran Arce F, Ramachandran S, Kagan BL, Nussinov R, Lal R. PMID: 22423218; PMCID: PMC3302213.

View in: PubMed Mentions: 22 Fields:
Bio Biochemistry Che Chemistry
Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology. J Phys Chem B. 2012 Feb 09; 116(5):1728-35. Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R. PMID: 22217000; PMCID: PMC4342054.

View in: PubMed Mentions: 48 Fields:
Che Chemistry
Translation:Humans Cells
Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions. Biochemistry. 2012 Jan 24; 51(3):776-85. Capone R, Jang H, Kotler SA, Kagan BL, Nussinov R, Lal R. PMID: 22242635; PMCID: PMC3265145.

View in: PubMed Mentions: 33 Fields:
Bio Biochemistry
Translation:Humans Cells
Membrane pores in the pathogenesis of neurodegenerative disease. Prog Mol Biol Transl Sci. 2012; 107:295-325. Kagan BL. PMID: 22482454.

View in: PubMed Mentions: 19 Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
Antimicrobial properties of amyloid peptides. Mol Pharm. 2012 Apr 02; 9(4):708-17. Kagan BL, Jang H, Capone R, Teran Arce F, Ramachandran S, Lal R, Nussinov R. PMID: 22081976; PMCID: PMC3297685.

View in: PubMed Mentions: 92 Fields:
Mol Molecular Biology Pha Pharmacology
Translation:Humans Animals
Antimicrobial amyloids? Biophys J. 2011 Apr 06; 100(7):1597-8. Kagan BL. PMID: 21463571; PMCID: PMC3072652.

View in: PubMed Mentions: 7 Fields:
Bio Biophysics
Translation:Humans Animals Cells
Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6538-43. Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R. PMID: 20308552; PMCID: PMC2851998.

View in: PubMed Mentions: 106 Fields:
Sci Science
Translation:Humans Cells
Amyloid peptide pores and the beta sheet conformation. Adv Exp Med Biol. 2010; 677:150-67. Kagan BL, Thundimadathil J. PMID: 20687488.

View in: PubMed Mentions: 25 Fields:
Bio Biology Med Medicine (General)
Translation:Humans Animals Cells
Membrane activity of an amphiphilic alpha-helical membrane-proximal cytoplasmic domain of the MoMuLV envelope glycoprotein. Exp Mol Pathol. 2008 Feb; 84(1):9-17. Epand RF, Zhang YL, Mirzabekov T, Kagan B, Silberstein A, Hubbell WL, Epand RM, Chakraborti S, Dimitrov DS, Anderson WF, Rozenberg-Adler Y. PMID: 18206141.

View in: PubMed Mentions: 5 Fields:
Mol Molecular Biology Pat Pathology
Translation:Cells
Alzheimer Research Forum Live Discussion: Now you see them, now you don't: The amyloid channel hypothesis. J Alzheimers Dis. 2006 Jul; 9(2):219-24. Fagan T, Kagan B, Corbin D, Hwang W, Glabe C, Nault L, Lal R, Teplow D, Albensi B, Sokolov Y. PMID: 16873968.

View in: PubMed Mentions: 2 Fields:
Ger Geriatrics Neu Neurology
Translation:Humans Cells
Amyloid ion channels: a common structural link for protein-misfolding disease. Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10427-32. Quist A, Doudevski I, Lin H, Azimova R, Ng D, Frangione B, Kagan B, Ghiso J, Lal R. PMID: 16020533; PMCID: PMC1180768.

View in: PubMed Mentions: 364 Fields:
Sci Science
Translation:Cells
Amyloidosis and protein folding. Science. 2005 Jan 07; 307(5706):42-3; author reply 42-3. Kagan BL. PMID: 15641174.

View in: PubMed Mentions: 10 Fields:
Sci Science
Translation:Humans Cells
Amyloid peptide channels. J Membr Biol. 2004 Nov; 202(1):1-10. Kagan BL, Azimov R, Azimova R. PMID: 15702375.

View in: PubMed Mentions: 56 Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
Electrophysiologic properties of channels induced by Abeta25-35 in planar lipid bilayers. Peptides. 2002 Jul; 23(7):1215-28. Lin MC, Kagan BL. PMID: 12128079.

View in: PubMed Mentions: 32 Fields:
Bio Biochemistry
Translation:Humans
The channel hypothesis of Alzheimer's disease: current status. Peptides. 2002 Jul; 23(7):1311-5. Kagan BL, Hirakura Y, Azimov R, Azimova R, Lin MC. PMID: 12128087.

View in: PubMed Mentions: 79 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense. Amyloid. 2002 Mar; 9(1):13-23. Hirakura Y, Carreras I, Sipe JD, Kagan BL. PMID: 12000193.

View in: PubMed Mentions: 42 Fields:
Bio Biochemistry
Translation:Humans Cells
The channel hypothesis of Huntington's disease. Brain Res Bull. 2001 Oct-Nov 1; 56(3-4):281-4. Kagan BL, Hirakura Y, Azimov R, Azimova R. PMID: 11719262.

View in: PubMed Mentions: 7 Fields:
Bra Brain
Translation:Humans Cells