David S Eisenberg

Title(s)Professor, Biological Chemistry
SchoolMedicine
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    Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer's Disease and Related Dementias
    NIH U24AG072458Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    Towards Treatment of Alzheimer?s Disease by Targeting Pathogenic Tau and Beta-Amyloid Structures
    NIH R56AG070895Apr 1, 2021 - Mar 31, 2023
    Role: Principal Investigator
    Identifying distinct tau polymorphs in Alzheimer?s disease and development of early diagnostics for aggregation of tau polymorphs
    NIH R56AG061847Sep 30, 2018 - Aug 31, 2020
    Role: Principal Investigator
    Structure and Inhibition of Amyloid in Alzheimer's Disease
    NIH RF1AG054022Sep 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Development of inhibitors and diagnostics for amyloid diseases
    NIH RF1AG048120Sep 1, 2014 - Mar 31, 2024
    Role: Principal Investigator
    Development of inhibitors for systemic amyloid diseases
    NIH R01AG048120Sep 1, 2014 - May 31, 2019
    Role: Principal Investigator
    Enhancing crystallization with binding partners, symmetry and diversity
    NIH P01GM098177Jun 1, 2012 - May 31, 2017
    Role: Co-Principal Investigator
    Engineering of Proteins for Crystallography
    NIH R01GM095847Sep 30, 2011 - Jul 31, 2016
    Role: Co-Principal Investigator
    Structural Biology of Amyloid Disease
    NIH R01AG029430Sep 1, 2007 - May 31, 2018
    Role: Principal Investigator
    A Core Database of Interacting Proteins
    NIH R01GM071909Jul 1, 2004 - Sep 30, 2014
    Role: Co-Principal Investigator
    SITE SPECIFIC TARGETING OF REGULATORY REGIONS OF HIV RNA
    NIH P01GM039558Sep 1, 1987 - Aug 31, 1997
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bioinformatic identification of TRK-fused gene protein (TFG) as a previously unrecognized amyloidogenic protein. J Biol Chem. 2022 Apr 08; 101920. Rosenberg GM, Murray KA, Salwinski L, Hughes MP, Abskharon R, Eisenberg DS. PMID: 35405097.
      View in: PubMed   Mentions:
    2. Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation. Proc Natl Acad Sci U S A. 2022 Apr 12; 119(15):e2119952119. Abskharon R, Sawaya MR, Boyer DR, Cao Q, Nguyen BA, Cascio D, Eisenberg DS. PMID: 35377792.
      View in: PubMed   Mentions:
    3. Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43. Nature. 2022 Mar 28. Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, Dickson DW, Fu JY, Ogorzalek Loo RR, Loo JA, Eisenberg DS. PMID: 35344984.
      View in: PubMed   Mentions:
    4. Extended β-Strands Contribute to Reversible Amyloid Formation. ACS Nano. 2022 02 22; 16(2):2154-2163. Murray KA, Evans D, Hughes MP, Sawaya MR, Hu CJ, Houk KN, Eisenberg D. PMID: 35132852.
      View in: PubMed   Mentions:
    5. Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices. Protein Sci. 2022 03; 31(3):716-727. Gray ALH, Sawaya MR, Acharyya D, Lou J, Edington EM, Best MD, Prosser RA, Eisenberg DS, Do TD. PMID: 34954854; PMCID: PMC8862425.
      View in: PubMed   Mentions:
    6. Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils. J Biol Chem. 2021 10; 297(4):101194. Hughes MP, Goldschmidt L, Eisenberg DS. PMID: 34537246; PMCID: PMC8551513.
      View in: PubMed   Mentions:
    7. The expanding amyloid family: Structure, stability, function, and pathogenesis. Cell. 2021 09 16; 184(19):4857-4873. Sawaya MR, Hughes MP, Rodriguez JA, Riek R, Eisenberg DS. PMID: 34534463; PMCID: PMC8772536.
      View in: PubMed   Mentions:    Fields:    
    8. Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores. Nat Struct Mol Biol. 2021 09; 28(9):724-730. Cao Q, Boyer DR, Sawaya MR, Abskharon R, Saelices L, Nguyen BA, Lu J, Murray KA, Kandeel F, Eisenberg DS. PMID: 34518699.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. bioRxiv. 2021 Mar 18. Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS. PMID: 33688654; PMCID: PMC7941625.
      View in: PubMed   Mentions: 1  
    10. Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines. Proc Natl Acad Sci U S A. 2021 01 12; 118(2). Shipps C, Kelly HR, Dahl PJ, Yi SM, Vu D, Boyer D, Glynn C, Sawaya MR, Eisenberg D, Batista VS, Malvankar NS. PMID: 33372136; PMCID: PMC7812754.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    11. Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid. 2020 Dec; 27(4):217-222. Benson MD, Buxbaum JN, Eisenberg DS, Merlini G, Saraiva MJM, Sekijima Y, Sipe JD, Westermark P. PMID: 33100054.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic Health
    12. CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun. 2020 08 14; 11(1):4090. Lu J, Cao Q, Hughes MP, Sawaya MR, Boyer DR, Cascio D, Eisenberg DS. PMID: 32796831; PMCID: PMC7427792.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    13. Half a century of amyloids: past, present and future. Chem Soc Rev. 2020 Aug 07; 49(15):5473-5509. Ke PC, Zhou R, Serpell LC, Riek R, Knowles TPJ, Lashuel HA, Gazit E, Hamley IW, Davis TP, Fändrich M, Otzen DE, Chapman MR, Dobson CM, Eisenberg DS, Mezzenga R. PMID: 32632432; PMCID: PMC7445747.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    14. Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils. Nat Struct Mol Biol. 2020 07; 27(7):653-659. Cao Q, Boyer DR, Sawaya MR, Ge P, Eisenberg DS. PMID: 32541896; PMCID: PMC8579859.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J Biol Chem. 2020 07 31; 295(31):10662-10676. Abskharon R, Seidler PM, Sawaya MR, Cascio D, Yang TP, Philipp S, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Felgner PL, Nakajima R, Glabe CG, Eisenberg DS. PMID: 32493775; PMCID: PMC7397112.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core. Nat Struct Mol Biol. 2020 05; 27(5):417-423. Glynn C, Sawaya MR, Ge P, Gallagher-Jones M, Short CW, Bowman R, Apostol M, Zhou ZH, Eisenberg DS, Rodriguez JA. PMID: 32284600; PMCID: PMC7338044.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    17. The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure. Proc Natl Acad Sci U S A. 2020 02 18; 117(7):3592-3602. Boyer DR, Li B, Sun C, Fan W, Zhou K, Hughes MP, Sawaya MR, Jiang L, Eisenberg DS. PMID: 32015135; PMCID: PMC7035510.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    18. Inhibition of synucleinopathic seeding by rationally designed inhibitors. Elife. 2020 01 02; 9. Sangwan S, Sahay S, Murray KA, Morgan S, Guenther EL, Jiang L, Williams CK, Vinters HV, Goedert M, Eisenberg DS. PMID: 31895037; PMCID: PMC6977966.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    19. Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid. Nat Commun. 2019 11 20; 10(1):5256. Basavalingappa V, Bera S, Xue B, Azuri I, Tang Y, Tao K, Shimon LJW, Sawaya MR, Kolusheva S, Eisenberg DS, Kronik L, Cao Y, Wei G, Gazit E. PMID: 31748568; PMCID: PMC6868146.
      View in: PubMed   Mentions: 3     Fields:    
    20. Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat Struct Mol Biol. 2019 11; 26(11):1044-1052. Boyer DR, Li B, Sun C, Fan W, Sawaya MR, Jiang L, Eisenberg DS. PMID: 31695184; PMCID: PMC6907165.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    21. Structure-based inhibitors of amyloid beta core suggest a common interface with tau. Elife. 2019 10 15; 8. Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. PMID: 31612856; PMCID: PMC6850776.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    22. Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat Struct Mol Biol. 2019 Oct; 26(10):988. Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. PMID: 31530939; PMCID: PMC7103477.
      View in: PubMed   Mentions:    Fields:    
    23. Non-proteinaceous hydrolase comprised of a phenylalanine metallo-supramolecular amyloid-like structure. Nat Catal. 2019 Nov; 2(11):977-985. Makam P, Yamijala SSRKC, Tao K, Shimon LJW, Eisenberg DS, Sawaya MR, Wong BM, Gazit E. PMID: 31742246; PMCID: PMC6861134.
      View in: PubMed   Mentions: 8  
    24. Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. J Biol Chem. 2019 11 01; 294(44):16451-16464. Seidler PM, Boyer DR, Murray KA, Yang TP, Bentzel M, Sawaya MR, Rosenberg G, Cascio D, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Eisenberg DS. PMID: 31537646; PMCID: PMC6827308.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    25. Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun. 2019 07 26; 10(1):3357. Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG. PMID: 31350392; PMCID: PMC6659688.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    26. Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat Struct Mol Biol. 2019 07; 26(7):619-627. Cao Q, Boyer DR, Sawaya MR, Ge P, Eisenberg DS. PMID: 31235914; PMCID: PMC7047951.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    27. Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation. Front Mol Neurosci. 2019; 12:54. Lu J, Cao Q, Wang C, Zheng J, Luo F, Xie J, Li Y, Ma X, He L, Eisenberg D, Nowick J, Jiang L, Li D. PMID: 30886570; PMCID: PMC6409328.
      View in: PubMed   Mentions: 14  
    28. A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils. J Biol Chem. 2019 04 12; 294(15):6130-6141. Saelices L, Nguyen BA, Chung K, Wang Y, Ortega A, Lee JH, Coelho T, Bijzet J, Benson MD, Eisenberg DS. PMID: 30733338; PMCID: PMC6463714.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    29. Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid. 2018 Dec; 25(4):215-219. Benson MD, Buxbaum JN, Eisenberg DS, Merlini G, Saraiva MJM, Sekijima Y, Sipe JD, Westermark P. PMID: 30614283.
      View in: PubMed   Mentions: 96     Fields:    Translation:Humans
    30. Author Correction: Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat Chem. 2018 12; 10(12):1267. Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L. PMID: 30420778; PMCID: PMC7124629.
      View in: PubMed   Mentions: 1     Fields:    
    31. Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems. J Mol Biol. 2019 01 18; 431(2):289-307. Tuukkanen AT, Freire D, Chan S, Arbing MA, Reed RW, Evans TJ, Zenkeviciute G, Kim J, Kahng S, Sawaya MR, Chaton CT, Wilmanns M, Eisenberg D, Parret AHA, Korotkov KV. PMID: 30419243; PMCID: PMC6331215.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    32. TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. Nature. 2018 11; 563(7732):508-513. Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB, Parker R. PMID: 30464263; PMCID: PMC6324568.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    33. Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis. J Biol Chem. 2018 12 21; 293(51):19659-19671. Brumshtein B, Esswein SR, Sawaya MR, Rosenberg G, Ly AT, Landau M, Eisenberg DS. PMID: 30355736; PMCID: PMC6314132.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    34. Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat Chem. 2018 12; 10(12):1213-1221. Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L. PMID: 30297750; PMCID: PMC6250578.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    35. Assessment of the effects of transthyretin peptide inhibitors in Drosophila models of neuropathic ATTR. Neurobiol Dis. 2018 12; 120:118-125. Saelices L, Pokrzywa M, Pawelek K, Eisenberg DS. PMID: 30213731; PMCID: PMC6186191.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    36. Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel. Nat Commun. 2018 09 06; 9(1):3609. Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L. PMID: 30190461; PMCID: PMC6127345.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    37. Atomic insights into the genesis of cellular filaments by globular proteins. Nat Struct Mol Biol. 2018 08; 25(8):705-714. McPartland L, Heller DM, Eisenberg DS, Hochschild A, Sawaya MR. PMID: 30076408; PMCID: PMC6185745.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    38. Paul D. Boyer (1918-2018). Science. 2018 Jul 27; 361(6400):334. Eisenberg DS. PMID: 30049866.
      View in: PubMed   Mentions:    Fields:    
    39. How Hard It Is Seeing What Is in Front of Your Eyes. Cell. 2018 06 28; 174(1):8-11. Eisenberg DS. PMID: 29958112.
      View in: PubMed   Mentions:    Fields:    
    40. Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6741-E6750. Saelices L, Chung K, Lee JH, Cohn W, Whitelegge JP, Benson MD, Eisenberg DS. PMID: 29954863; PMCID: PMC6055172.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    41. Crystal structures of amyloidogenic segments of human transthyretin. Protein Sci. 2018 07; 27(7):1295-1303. Saelices L, Sievers SA, Sawaya MR, Eisenberg DS. PMID: 29626847; PMCID: PMC6032358.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    42. Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat Struct Mol Biol. 2018 06; 25(6):463-471. Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. PMID: 29786080; PMCID: PMC5990464.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    43. Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2. Nat Struct Mol Biol. 2018 04; 25(4):311-319. Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS. PMID: 29531287; PMCID: PMC6056015.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    44. Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations. Protein Sci. 2018 07; 27(7):1231-1242. Sangwan S, Sawaya MR, Murray KA, Hughes MP, Eisenberg DS. PMID: 29453800; PMCID: PMC6032342.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    45. Distal amyloid β-protein fragments template amyloid assembly. Protein Sci. 2018 07; 27(7):1181-1190. Do TD, Sangwan S, de Almeida NEC, Ilitchev AI, Giammona M, Sawaya MR, Buratto SK, Eisenberg DS, Bowers MT. PMID: 29349888; PMCID: PMC6032360.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    46. Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks. Science. 2018 02 09; 359(6376):698-701. Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS. PMID: 29439243; PMCID: PMC6192703.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    47. Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp. Nat Struct Mol Biol. 2018 02; 25(2):131-134. Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA. PMID: 29335561; PMCID: PMC6170007.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    48. Ultrafast Time-Resolved Studies on Fluorescein for Recognition Strands Architecture in Amyloid Fibrils. J Phys Chem B. 2018 01 11; 122(1):8-18. Hanczyc P, Mikhailovsky A, Boyer DR, Sawaya MR, Heeger A, Eisenberg D. PMID: 29237120.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    49. Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. J Biol Chem. 2018 02 23; 293(8):2888-2902. Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. PMID: 29282295; PMCID: PMC5827424.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    50. Asparagine and glutamine ladders promote cross-species prion conversion. J Biol Chem. 2017 11 17; 292(46):19076-19086. Kurt TD, Aguilar-Calvo P, Jiang L, Rodriguez JA, Alderson N, Eisenberg DS, Sigurdson CJ. PMID: 28931606; PMCID: PMC5704488.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    51. Toward the Atomic Structure of PrPSc. Cold Spring Harb Perspect Biol. 2017 Sep 01; 9(9). Rodriguez JA, Jiang L, Eisenberg DS. PMID: 28096267; PMCID: PMC5585850.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    52. Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8770-8775. Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS. PMID: 28760994; PMCID: PMC5565441.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    53. Propagation of Tau Aggregates and Neurodegeneration. Annu Rev Neurosci. 2017 07 25; 40:189-210. Goedert M, Eisenberg DS, Crowther RA. PMID: 28772101.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    54. Neurodegeneration: Taming tangled tau. Nature. 2017 07 13; 547(7662):170-171. Eisenberg DS, Sawaya MR. PMID: 28678777; PMCID: PMC6400062.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    55. Taking the measure of MicroED. Curr Opin Struct Biol. 2017 10; 46:79-86. Rodriguez JA, Eisenberg DS, Gonen T. PMID: 28648726; PMCID: PMC5683914.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    56. Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser. Cytoskeleton (Hoboken). 2017 Dec; 74(12):472-481. Popp D, Loh ND, Zorgati H, Ghoshdastider U, Liow LT, Ivanova MI, Larsson M, DePonte DP, Bean R, Beyerlein KR, Gati C, Oberthuer D, Arnlund D, Brändén G, Berntsen P, Cascio D, Chavas LMG, Chen JPJ, Ding K, Fleckenstein H, Gumprecht L, Harimoorthy R, Mossou E, Sawaya MR, Brewster AS, Hattne J, Sauter NK, Seibert M, Seuring C, Stellato F, Tilp T, Eisenberg DS, Messerschmidt M, Williams GJ, Koglin JE, Makowski L, Millane RP, Forsyth T, Boutet S, White TA, Barty A, Chapman H, Chen SL, Liang M, Neutze R, Robinson RC. PMID: 28574190.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    57. Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat Methods. 2017 Feb 13; 14(4):399-402. de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T. PMID: 28192420; PMCID: PMC5376236.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    58. In memoriam-Rainer Jaenicke. Protein Sci. 2017 03; 26(3):394-395. Buchner J, Eisenberg D, Schmid F. PMID: 27977893; PMCID: PMC5326554.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    59. Structural Studies of Amyloid Proteins at the Molecular Level. Annu Rev Biochem. 2017 06 20; 86:69-95. Eisenberg DS, Sawaya MR. PMID: 28125289.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    60. Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity. Elife. 2017 01 03; 6. Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS. PMID: 28045370; PMCID: PMC5207774.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    61. The activities of amyloids from a structural perspective. Nature. 2016 11 10; 539(7628):227-235. Riek R, Eisenberg DS. PMID: 27830791.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    62. De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure. Nature. 2016 11 03; 539(7627):43-47. Colletier JP, Sawaya MR, Gingery M, Rodriguez JA, Cascio D, Brewster AS, Michels-Clark T, Hice RH, Coquelle N, Boutet S, Williams GJ, Messerschmidt M, DePonte DP, Sierra RG, Laksmono H, Koglin JE, Hunter MS, Park HW, Uervirojnangkoorn M, Bideshi DK, Brunger AT, Federici BA, Sauter NK, Eisenberg DS. PMID: 27680699; PMCID: PMC5161637.
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    63. Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED. Proc Natl Acad Sci U S A. 2016 10 04; 113(40):11232-11236. Sawaya MR, Rodriguez J, Cascio D, Collazo MJ, Shi D, Reyes FE, Hattne J, Gonen T, Eisenberg DS. PMID: 27647903; PMCID: PMC5056061.
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    64. Implications for Alzheimer's disease of an atomic resolution structure of amyloid-β(1-42) fibrils. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9398-400. Eisenberg DS, Sawaya MR. PMID: 27506787; PMCID: PMC5003263.
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    65. Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system. BMC Struct Biol. 2016 Feb 27; 16:5. Wagner JM, Chan S, Evans TJ, Kahng S, Kim J, Arbing MA, Eisenberg D, Korotkov KV. PMID: 26922638; PMCID: PMC4769845.
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    66. Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets. J Phys Chem B. 2016 07 07; 120(26):5810-6. Soriaga AB, Sangwan S, Macdonald R, Sawaya MR, Eisenberg D. PMID: 26629790; PMCID: PMC4936935.
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    67. Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels. J Am Chem Soc. 2016 Jan 20; 138(2):549-57. Do TD, LaPointe NE, Nelson R, Krotee P, Hayden EY, Ulrich B, Quan S, Feinstein SC, Teplow DB, Eisenberg D, Shea JE, Bowers MT. PMID: 26700445; PMCID: PMC4741107.
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    68. Perspective on SOD1 mediated toxicity in Amyotrophic Lateral Sclerosis. Postepy Biochem. 2016; 62(3):362-369. Sangwan S, Eisenberg DS. PMID: 28132491.
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    69. Preparation of Crystalline Samples of Amyloid Fibrils and Oligomers. Methods Mol Biol. 2016; 1345:201-10. Moshe A, Landau M, Eisenberg D. PMID: 26453214.
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    70. A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 2016 Jan 11; 29(1):90-103. Soragni A, Janzen DM, Johnson LM, Lindgren AG, Thai-Quynh Nguyen A, Tiourin E, Soriaga AB, Lu J, Jiang L, Faull KF, Pellegrini M, Memarzadeh S, Eisenberg DS. PMID: 26748848; PMCID: PMC4733364.
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    71. Ketones block amyloid entry and improve cognition in an Alzheimer's model. Neurobiol Aging. 2016 Mar; 39:25-37. Yin JX, Maalouf M, Han P, Zhao M, Gao M, Dharshaun T, Ryan C, Whitelegge J, Wu J, Eisenberg D, Reiman EM, Schweizer FE, Shi J. PMID: 26923399.
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    72. Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. Elife. 2015 Nov 18; 4:e10935. Brumshtein B, Esswein SR, Salwinski L, Phillips ML, Ly AT, Cascio D, Sawaya MR, Eisenberg DS. PMID: 26576950; PMCID: PMC4758944.
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    73. Uncovering the Mechanism of Aggregation of Human Transthyretin. J Biol Chem. 2015 Nov 27; 290(48):28932-43. Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS. PMID: 26459562; PMCID: PMC4661406.
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    74. Structure of the toxic core of α-synuclein from invisible crystals. Nature. 2015 Sep 24; 525(7570):486-90. Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. PMID: 26352473; PMCID: PMC4791177.
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    75. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Jun; 125(6):2548. Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. PMID: 25961458; PMCID: PMC4497774.
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    76. Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation. Mol Cell. 2015 Mar 19; 57(6):1011-1021. Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU. PMID: 25728769; PMCID: PMC4904734.
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    78. Indexing amyloid peptide diffraction from serial femtosecond crystallography: new algorithms for sparse patterns. Acta Crystallogr D Biol Crystallogr. 2015 Feb; 71(Pt 2):357-66. Brewster AS, Sawaya MR, Rodriguez J, Hattne J, Echols N, McFarlane HT, Cascio D, Adams PD, Eisenberg DS, Sauter NK. PMID: 25664747; PMCID: PMC4321489.
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    79. Structure-based design of functional amyloid materials. J Am Chem Soc. 2014 Dec 31; 136(52):18044-51. Li D, Jones EM, Sawaya MR, Furukawa H, Luo F, Ivanova M, Sievers SA, Wang W, Yaghi OM, Liu C, Eisenberg DS. PMID: 25474758.
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    80. Enhanced photoelectrochemical water oxidation on bismuth vanadate by electrodeposition of amorphous titanium dioxide. J Am Chem Soc. 2014 Oct 08; 136(40):14011-4. Eisenberg D, Ahn HS, Bard AJ. PMID: 25243345.
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    81. Formation of amyloid fibers by monomeric light chain variable domains. J Biol Chem. 2014 Oct 03; 289(40):27513-25. Brumshtein B, Esswein SR, Landau M, Ryan CM, Whitelegge JP, Phillips ML, Cascio D, Sawaya MR, Eisenberg DS. PMID: 25138218; PMCID: PMC4183792.
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    82. Protein crystal structure obtained at 2.9 Å resolution from injecting bacterial cells into an X-ray free-electron laser beam. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12769-74. Sawaya MR, Cascio D, Gingery M, Rodriguez J, Goldschmidt L, Colletier JP, Messerschmidt MM, Boutet S, Koglin JE, Williams GJ, Brewster AS, Nass K, Hattne J, Botha S, Doak RB, Shoeman RL, DePonte DP, Park HW, Federici BA, Sauter NK, Schlichting I, Eisenberg DS. PMID: 25136092; PMCID: PMC4156696.
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    83. Factors that drive peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants. J Phys Chem B. 2014 Jul 03; 118(26):7247-56. Do TD, LaPointe NE, Sangwan S, Teplow DB, Feinstein SC, Sawaya MR, Eisenberg DS, Bowers MT. PMID: 24915112; PMCID: PMC4084844.
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    84. The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):E1562-70. Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A. PMID: 24711386; PMCID: PMC4000792.
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    85. A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. Protein Sci. 2014 May; 23(5):576-85. Korman TP, Sahachartsiri B, Li D, Vinokur JM, Eisenberg D, Bowie JU. PMID: 24623472; PMCID: PMC4005709.
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    86. A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC. J Biol Chem. 2014 Apr 11; 289(15):10660-10667. Kurt TD, Jiang L, Bett C, Eisenberg D, Sigurdson CJ. PMID: 24596090; PMCID: PMC4036184.
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    87. Salvage or recovery of failed targets by mutagenesis to reduce surface entropy. Methods Mol Biol. 2014; 1140:201-9. Goldschmidt L, Eisenberg D, Derewenda ZS. PMID: 24590720.
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    88. Designed amyloid fibers as materials for selective carbon dioxide capture. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):191-6. Li D, Furukawa H, Deng H, Liu C, Yaghi OM, Eisenberg DS. PMID: 24367077; PMCID: PMC3890842.
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    89. Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):197-201. Ivanova MI, Sievers SA, Guenther EL, Johnson LM, Winkler DD, Galaleldeen A, Sawaya MR, Hart PJ, Eisenberg DS. PMID: 24344300; PMCID: PMC3890817.
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    90. Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions. PLoS One. 2013; 8(11):e81753. Arbing MA, Chan S, Harris L, Kuo E, Zhou TT, Ahn CJ, Nguyen L, He Q, Lu J, Menchavez PT, Shin A, Holton T, Sawaya MR, Cascio D, Eisenberg D. PMID: 24312350; PMCID: PMC3843698.
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    91. Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. Elife. 2013 Jul 16; 2:e00857. Jiang L, Liu C, Leibly D, Landau M, Zhao M, Hughes MP, Eisenberg DS. PMID: 23878726; PMCID: PMC3713518.
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    92. Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes. Structure. 2013 Apr 02; 21(4):627-37. Miallau L, Jain P, Arbing MA, Cascio D, Phan T, Ahn CJ, Chan S, Chernishof I, Maxson M, Chiang J, Jacobs WR, Eisenberg DS. PMID: 23523424; PMCID: PMC3791866.
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    93. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):20913-8. Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D. PMID: 23213214; PMCID: PMC3529048.
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    94. The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg²⁺ ion in the active site and a putative RNA-binding site. Protein Sci. 2012 Nov; 21(11):1754-67. Min AB, Miallau L, Sawaya MR, Habel J, Cascio D, Eisenberg D. PMID: 23011806; PMCID: PMC3527712.
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    95. Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity. Nat Chem. 2012 Nov; 4(11):927-33. Cheng PN, Liu C, Zhao M, Eisenberg D, Nowick JS. PMID: 23089868; PMCID: PMC3481199.
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    96. Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell. 2012 May 11; 149(4):753-67. Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, Grishin NV, Frantz DE, Schneider JW, Chen S, Li L, Sawaya MR, Eisenberg D, Tycko R, McKnight SL. PMID: 22579281; PMCID: PMC6347373.
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    98. The amyloid state of proteins in human diseases. Cell. 2012 Mar 16; 148(6):1188-203. Eisenberg D, Jucker M. PMID: 22424229; PMCID: PMC3353745.
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    100. Ribonuclease A suggests how proteins self-chaperone against amyloid fiber formation. Protein Sci. 2012 Jan; 21(1):26-37. Teng PK, Anderson NJ, Goldschmidt L, Sawaya MR, Sambashivan S, Eisenberg D. PMID: 22095666; PMCID: PMC3323778.
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    102. PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods. 2011 Jun 29; 8(7):528-9. Aranda B, Blankenburg H, Kerrien S, Brinkman FS, Ceol A, Chautard E, Dana JM, De Las Rivas J, Dumousseau M, Galeota E, Gaulton A, Goll J, Hancock RE, Isserlin R, Jimenez RC, Kerssemakers J, Khadake J, Lynn DJ, Michaut M, O'Kelly G, Ono K, Orchard S, Prieto C, Razick S, Rigina O, Salwinski L, Simonovic M, Velankar S, Winter A, Wu G, Bader GD, Cesareni G, Donaldson IM, Eisenberg D, Kleywegt GJ, Overington J, Ricard-Blum S, Tyers M, Albrecht M, Hermjakob H. PMID: 21716279; PMCID: PMC3246345.
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    103. Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature. 2011 Jun 15; 475(7354):96-100. Sievers SA, Karanicolas J, Chang HW, Zhao A, Jiang L, Zirafi O, Stevens JT, Münch J, Baker D, Eisenberg D. PMID: 21677644; PMCID: PMC4073670.
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    104. Towards a pharmacophore for amyloid. PLoS Biol. 2011 Jun; 9(6):e1001080. Landau M, Sawaya MR, Faull KF, Laganowsky A, Jiang L, Sievers SA, Liu J, Barrio JR, Eisenberg D. PMID: 21695112; PMCID: PMC3114762.
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    105. Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation. Protein Sci. 2011 Jun; 20(6):996-1004. Zhao M, Cascio D, Sawaya MR, Eisenberg D. PMID: 21462277; PMCID: PMC3104229.
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    108. Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide. J Am Chem Soc. 2011 Mar 09; 133(9):3144-57. Zheng J, Liu C, Sawaya MR, Vadla B, Khan S, Woods RJ, Eisenberg D, Goux WJ, Nowick JS. PMID: 21319744; PMCID: PMC3048834.
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    109. The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinb). 2011 Mar; 91(2):155-72. Chim N, Habel JE, Johnston JM, Krieger I, Miallau L, Sankaranarayanan R, Morse RP, Bruning J, Swanson S, Kim H, Kim CY, Li H, Bulloch EM, Payne RJ, Manos-Turvey A, Hung LW, Baker EN, Lott JS, James MN, Terwilliger TC, Eisenberg DS, Sacchettini JC, Goulding CW. PMID: 21247804; PMCID: PMC3310434.
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    110. β₂-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages. Nat Struct Mol Biol. 2011 Jan; 18(1):49-55. Liu C, Sawaya MR, Eisenberg D. PMID: 21131979; PMCID: PMC3058263.
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    111. The crystal structure of the Mycobacterium tuberculosis Rv3019c-Rv3020c ESX complex reveals a domain-swapped heterotetramer. Protein Sci. 2010 Sep; 19(9):1692-703. Arbing MA, Kaufmann M, Phan T, Chan S, Cascio D, Eisenberg D. PMID: 20629176; PMCID: PMC2975133.
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    113. Crystallographic studies of prion protein (PrP) segments suggest how structural changes encoded by polymorphism at residue 129 modulate susceptibility to human prion disease. J Biol Chem. 2010 Sep 24; 285(39):29671-5. Apostol MI, Sawaya MR, Cascio D, Eisenberg D. PMID: 20685658; PMCID: PMC2943325.
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    114. Synthetic approaches to aromatic belts: building up strain in macrocyclic polyarenes. Chem Soc Rev. 2010 Aug; 39(8):2879-90. Eisenberg D, Shenhar R, Rabinovitz M. PMID: 20532265.
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    116. Multidimensional structure-activity relationship of a protein in its aggregated states. Angew Chem Int Ed Engl. 2010 May 25; 49(23):3904-8. Wang L, Schubert D, Sawaya MR, Eisenberg D, Riek R. PMID: 20397175; PMCID: PMC3004770.
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    117. Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci. 2010 May; 19(5):1031-43. Laganowsky A, Benesch JL, Landau M, Ding L, Sawaya MR, Cascio D, Huang Q, Robinson CV, Horwitz J, Eisenberg D. PMID: 20440841; PMCID: PMC2868245.
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    119. Detecting coordinated regulation of multi-protein complexes using logic analysis of gene expression. BMC Syst Biol. 2009 Dec 14; 3:115. Sprinzak E, Cokus SJ, Yeates TO, Eisenberg D, Pellegrini M. PMID: 20003439; PMCID: PMC2804736.
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    120. Recurated protein interaction datasets. Nat Methods. 2009 Dec; 6(12):860-1. Salwinski L, Licata L, Winter A, Thorneycroft D, Khadake J, Ceol A, Aryamontri AC, Oughtred R, Livstone M, Boucher L, Botstein D, Dolinski K, Berardini T, Huala E, Tyers M, Eisenberg D, Cesareni G, Hermjakob H. PMID: 19935838.
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    121. Molecular basis for insulin fibril assembly. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):18990-5. Ivanova MI, Sievers SA, Sawaya MR, Wall JS, Eisenberg D. PMID: 19864624; PMCID: PMC2776439.
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    122. Molecular mechanisms for protein-encoded inheritance. Nat Struct Mol Biol. 2009 Sep; 16(9):973-8. Wiltzius JJ, Landau M, Nelson R, Sawaya MR, Apostol MI, Goldschmidt L, Soriaga AB, Cascio D, Rajashankar K, Eisenberg D. PMID: 19684598; PMCID: PMC3640378.
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    123. Short protein segments can drive a non-fibrillizing protein into the amyloid state. Protein Eng Des Sel. 2009 Aug; 22(8):531-6. Teng PK, Eisenberg D. PMID: 19602569; PMCID: PMC2719503.
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    124. Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process. Protein Sci. 2009 Jul; 18(7):1521-30. Wiltzius JJ, Sievers SA, Sawaya MR, Eisenberg D. PMID: 19475663; PMCID: PMC2775219.
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    125. Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science. 2009 Jul 17; 325(5938):328-32. Maji SK, Perrin MH, Sawaya MR, Jessberger S, Vadodaria K, Rissman RA, Singru PS, Nilsson KP, Simon R, Schubert D, Eisenberg D, Rivier J, Sawchenko P, Vale W, Riek R. PMID: 19541956; PMCID: PMC2865899.
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    126. Expanding metabolism for biosynthesis of nonnatural alcohols. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20653-8. Zhang K, Sawaya MR, Eisenberg DS, Liao JC. PMID: 19064911; PMCID: PMC2634914.
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    127. Annotating proteins with generalized functional linkages. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17700-5. Llewellyn R, Eisenberg DS. PMID: 19004787; PMCID: PMC2584710.
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    128. Inferring molecular function: contributions from functional linkages. Trends Genet. 2008 Dec; 24(12):587-90. Medrano-Soto A, Pal D, Eisenberg D. PMID: 18951645.
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    129. Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem. 2009 Jan 02; 284(1):276-283. Miallau L, Faller M, Chiang J, Arbing M, Guo F, Cascio D, Eisenberg D. PMID: 18952600; PMCID: PMC2610494.
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    130. A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell. 2008 Sep 19; 134(6):1007-18. Sawaya MR, Wojtowicz WM, Andre I, Qian B, Wu W, Baker D, Eisenberg D, Zipursky SL. PMID: 18805093; PMCID: PMC2701508.
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    131. Identifying cognate binding pairs among a large set of paralogs: the case of PE/PPE proteins of Mycobacterium tuberculosis. PLoS Comput Biol. 2008 Sep 12; 4(9):e1000174. Riley R, Pellegrini M, Eisenberg D. PMID: 18787688; PMCID: PMC2519833.
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    132. Bacterial inclusion bodies contain amyloid-like structure. PLoS Biol. 2008 Aug 05; 6(8):e195. Wang L, Maji SK, Sawaya MR, Eisenberg D, Riek R. PMID: 18684013; PMCID: PMC2494559.
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    133. Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest. 2008 Aug; 118(8):2917-28. Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. PMID: 18636118; PMCID: PMC2467381.
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    134. The structure of a fibril-forming sequence, NNQQNY, in the context of a globular fold. Protein Sci. 2008 Sep; 17(9):1617-23. Guo Z, Eisenberg D. PMID: 18552127; PMCID: PMC2525518.
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    135. Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci. 2008 Sep; 17(9):1467-74. Wiltzius JJ, Sievers SA, Sawaya MR, Cascio D, Popov D, Riekel C, Eisenberg D. PMID: 18556473; PMCID: PMC2525530.
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    136. Using inferred residue contacts to distinguish between correct and incorrect protein models. Bioinformatics. 2008 Jul 15; 24(14):1575-82. Miller CS, Eisenberg D. PMID: 18511466; PMCID: PMC2638260.
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    137. The origin of protein interactions and allostery in colocalization. Nature. 2007 Dec 13; 450(7172):983-90. Kuriyan J, Eisenberg D. PMID: 18075577.
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    138. Draft crystal structure of the vault shell at 9-A resolution. PLoS Biol. 2007 Nov; 5(11):e318. Anderson DH, Kickhoefer VA, Sievers SA, Rome LH, Eisenberg D. PMID: 18044992; PMCID: PMC2229873.
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    139. Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions. BMC Biol. 2007 Oct 09; 5:44. Kerrien S, Orchard S, Montecchi-Palazzi L, Aranda B, Quinn AF, Vinod N, Bader GD, Xenarios I, Wojcik J, Sherman D, Tyers M, Salama JJ, Moore S, Ceol A, Chatr-Aryamontri A, Oesterheld M, Stümpflen V, Salwinski L, Nerothin J, Cerami E, Cusick ME, Vidal M, Gilson M, Armstrong J, Woollard P, Hogue C, Eisenberg D, Cesareni G, Apweiler R, Hermjakob H. PMID: 17925023; PMCID: PMC2189715.
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    140. Functional linkages can reveal protein complexes for structure determination. Structure. 2007 Sep; 15(9):1079-89. Kim SM, Bowers PM, Pal D, Strong M, Terwilliger TC, Kaufmann M, Eisenberg D. PMID: 17850747.
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    141. Toward rational protein crystallization: A Web server for the design of crystallizable protein variants. Protein Sci. 2007 Aug; 16(8):1569-76. Goldschmidt L, Cooper DR, Derewenda ZS, Eisenberg D. PMID: 17656576; PMCID: PMC2203352.
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    142. The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol. 2007 Aug; 25(8):894-8. Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, Greenblatt J, Bader J, Uetz P, Tyers M, Legrain P, Fields S, Mulder N, Gilson M, Niepmann M, Burgoon L, De Las Rivas J, Prieto C, Perreau VM, Hogue C, Mewes HW, Apweiler R, Xenarios I, Eisenberg D, Cesareni G, Hermjakob H. PMID: 17687370.
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    143. The MiSink Plugin: Cytoscape as a graphical interface to the Database of Interacting Proteins. Bioinformatics. 2007 Aug 15; 23(16):2193-5. Salwinski L, Eisenberg D. PMID: 17553858.
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    144. Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature. 2007 May 24; 447(7143):453-7. Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AØ, Riekel C, Eisenberg D. PMID: 17468747.
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    145. The mechanism of the amyloidogenic conversion of T7 endonuclease I. J Biol Chem. 2007 May 18; 282(20):14968-74. Guo Z, Eisenberg D. PMID: 17360710.
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    146. The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol. 2007 Mar; 5(3):e16. Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, Joachimiak MP, van Belle C, Chandonia JM, Soergel DA, Zhai Y, Natarajan K, Lee S, Raphael BJ, Bafna V, Friedman R, Brenner SE, Godzik A, Eisenberg D, Dixon JE, Taylor SS, Strausberg RL, Frazier M, Venter JC. PMID: 17355171; PMCID: PMC1821046.
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    147. Cooperative hydrogen bonding in amyloid formation. Protein Sci. 2007 Apr; 16(4):761-4. Tsemekhman K, Goldschmidt L, Eisenberg D, Baker D. PMID: 17327394; PMCID: PMC2203343.
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    148. The protein network as a tool for finding novel drug targets. Prog Drug Res. 2007; 64:191, 193-215. Strong M, Eisenberg D. PMID: 17195476.
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    149. A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase. J Biomol Screen. 2007 Feb; 12(1):100-5. White EL, Southworth K, Ross L, Cooley S, Gill RB, Sosa MI, Manouvakhova A, Rasmussen L, Goulding C, Eisenberg D, Fletcher TM. PMID: 17175524.
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    150. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol Microbiol. 2006 Nov; 62(3):667-79. Abdallah AM, Verboom T, Hannes F, Safi M, Strong M, Eisenberg D, Musters RJ, Vandenbroucke-Grauls CM, Appelmelk BJ, Luirink J, Bitter W. PMID: 17076665.
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    151. The structure and computational analysis of Mycobacterium tuberculosis protein CitE suggest a novel enzymatic function. J Mol Biol. 2007 Jan 12; 365(2):275-83. Goulding CW, Bowers PM, Segelke B, Lekin T, Kim CY, Terwilliger TC, Eisenberg D. PMID: 17064730.
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    152. The structural biology of protein aggregation diseases: Fundamental questions and some answers. Acc Chem Res. 2006 Sep; 39(9):568-75. Eisenberg D, Nelson R, Sawaya MR, Balbirnie M, Sambashivan S, Ivanova MI, Madsen AØ, Riekel C. PMID: 16981672; PMCID: PMC3017558.
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    153. Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8042-7. Guo Z, Eisenberg D. PMID: 16698921; PMCID: PMC1472426.
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    154. Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8060-5. Strong M, Sawaya MR, Wang S, Phillips M, Cascio D, Eisenberg D. PMID: 16690741; PMCID: PMC1472429.
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    155. Deposition diseases and 3D domain swapping. Structure. 2006 May; 14(5):811-24. Bennett MJ, Sawaya MR, Eisenberg D. PMID: 16698543.
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    156. Bioinformatic challenges for the next decade(s). Philos Trans R Soc Lond B Biol Sci. 2006 Mar 29; 361(1467):525-7. Eisenberg D, Marcotte E, McLachlan AD, Pellegrini M. PMID: 16524841; PMCID: PMC1609334.
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    157. Recent atomic models of amyloid fibril structure. Curr Opin Struct Biol. 2006 Apr; 16(2):260-5. Nelson R, Eisenberg D. PMID: 16563741.
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    158. A systematic screen of beta(2)-microglobulin and insulin for amyloid-like segments. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4079-82. Ivanova MI, Thompson MJ, Eisenberg D. PMID: 16537488; PMCID: PMC1449649.
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    159. The 3D profile method for identifying fibril-forming segments of proteins. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4074-8. Thompson MJ, Sievers SA, Karanicolas J, Ivanova MI, Baker D, Eisenberg D. PMID: 16537487; PMCID: PMC1449648.
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    160. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006 Mar 24; 311(5768):1770-3. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. PMID: 16497887.
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    161. Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action. Biochemistry. 2006 Feb 14; 45(6):1554-61. Wang S, Eisenberg D. PMID: 16460002.
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    162. Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosis. Infect Immun. 2006 Feb; 74(2):1233-42. Rachman H, Strong M, Ulrichs T, Grode L, Schuchhardt J, Mollenkopf H, Kosmiadi GA, Eisenberg D, Kaufmann SH. PMID: 16428773; PMCID: PMC1360294.
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    163. Mycobacterium tuberculosis gene expression profiling within the context of protein networks. Microbes Infect. 2006 Mar; 8(3):747-57. Rachman H, Strong M, Schaible U, Schuchhardt J, Hagens K, Mollenkopf H, Eisenberg D, Kaufmann SH. PMID: 16513384.
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    164. Structural models of amyloid-like fibrils. Adv Protein Chem. 2006; 73:235-82. Nelson R, Eisenberg D. PMID: 17190616.
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    165. Sociodemographic determinants of the utilization of specific types of complementary and alternative medicine: an analysis based on a nationally representative survey sample. J Altern Complement Med. 2005 Dec; 11(6):977-94. Conboy L, Patel S, Kaptchuk TJ, Gottlieb B, Eisenberg D, Acevedo-Garcia D. PMID: 16398589.
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    166. Utilizing logical relationships in genomic data to decipher cellular processes. FEBS J. 2005 Oct; 272(20):5110-8. Bowers PM, O'Connor BD, Cokus SJ, Sprinzak E, Yeates TO, Eisenberg D. PMID: 16218945.
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    167. Inferring protein domain interactions from databases of interacting proteins. Genome Biol. 2005; 6(10):R89. Riley R, Lee C, Sabatti C, Eisenberg D. PMID: 16207360; PMCID: PMC1257472.
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    168. Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure. Nature. 2005 Sep 08; 437(7056):266-9. Sambashivan S, Liu Y, Sawaya MR, Gingery M, Eisenberg D. PMID: 16148936.
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    169. Structure of the cross-beta spine of amyloid-like fibrils. Nature. 2005 Jun 09; 435(7043):773-8. Nelson R, Sawaya MR, Balbirnie M, Madsen AØ, Riekel C, Grothe R, Eisenberg D. PMID: 15944695; PMCID: PMC1479801.
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    170. Crystal structure of a RuBisCO-like protein from the green sulfur bacterium Chlorobium tepidum. Structure. 2005 May; 13(5):779-89. Li H, Sawaya MR, Tabita FR, Eisenberg D. PMID: 15893668.
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    171. Regulation by oligomerization in a mycobacterial folate biosynthetic enzyme. J Mol Biol. 2005 May 27; 349(1):61-72. Goulding CW, Apostol MI, Sawaya MR, Phillips M, Parseghian A, Eisenberg D. PMID: 15876368.
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    172. The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase. Acta Crystallogr D Biol Crystallogr. 2005 Mar; 61(Pt 3):309-15. Müller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D. PMID: 15735341.
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    173. Detection of parallel functional modules by comparative analysis of genome sequences. Nat Biotechnol. 2005 Feb; 23(2):253-60. Li H, Pellegrini M, Eisenberg D. PMID: 15696156.
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    174. Inference of protein function from protein structure. Structure. 2005 Jan; 13(1):121-30. Pal D, Eisenberg D. PMID: 15642267.
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    175. Use of logic relationships to decipher protein network organization. Science. 2004 Dec 24; 306(5705):2246-9. Bowers PM, Cokus SJ, Eisenberg D, Yeates TO. PMID: 15618515.
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    176. DPANN: improved sequence to structure alignments following fold recognition. Proteins. 2004 Aug 15; 56(3):528-38. Reinhardt A, Eisenberg D. PMID: 15229885.
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    177. The evolving role of 3D domain swapping in proteins. Structure. 2004 Aug; 12(8):1339-41. Bennett MJ, Eisenberg D. PMID: 15296726.
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    178. An amyloid-forming segment of beta2-microglobulin suggests a molecular model for the fibril. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10584-9. Ivanova MI, Sawaya MR, Gingery M, Attinger A, Eisenberg D. PMID: 15249659; PMCID: PMC489978.
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    179. In silico simulation of biological network dynamics. Nat Biotechnol. 2004 Aug; 22(8):1017-9. Salwinski L, Eisenberg D. PMID: 15235611.
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    180. A web-based comparative genomics tutorial for investigating microbial genomes. Microbiol Educ. 2004 May; 5:30-5. Strong M, Cascio D, Eisenberg D. PMID: 23653555; PMCID: PMC3633132.
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    181. Prolinks: a database of protein functional linkages derived from coevolution. Genome Biol. 2004; 5(5):R35. Bowers PM, Pellegrini M, Thompson MJ, Fierro J, Yeates TO, Eisenberg D. PMID: 15128449; PMCID: PMC416471.
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    182. The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol. 2004 Feb; 22(2):177-83. Hermjakob H, Montecchi-Palazzi L, Bader G, Wojcik J, Salwinski L, Ceol A, Moore S, Orchard S, Sarkans U, von Mering C, Roechert B, Poux S, Jung E, Mersch H, Kersey P, Lappe M, Li Y, Zeng R, Rana D, Nikolski M, Husi H, Brun C, Shanker K, Grant SG, Sander C, Bork P, Zhu W, Pandey A, Brazma A, Jacq B, Vidal M, Sherman D, Legrain P, Cesareni G, Xenarios I, Eisenberg D, Steipe B, Hogue C, Apweiler R. PMID: 14755292.
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    183. PFIT and PFRIT: bioinformatic algorithms for detecting glycosidase function from structure and sequence. Protein Sci. 2004 Jan; 13(1):221-9. Kleiger G, Panina EM, Mallick P, Eisenberg D. PMID: 14691237; PMCID: PMC2286537.
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    184. The Database of Interacting Proteins: 2004 update. Nucleic Acids Res. 2004 Jan 01; 32(Database issue):D449-51. Salwinski L, Miller CS, Smith AJ, Pettit FK, Bowie JU, Eisenberg D. PMID: 14681454; PMCID: PMC308820.
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    185. Visualization and interpretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps. Nucleic Acids Res. 2003 Dec 15; 31(24):7099-109. Strong M, Graeber TG, Beeby M, Pellegrini M, Thompson MJ, Yeates TO, Eisenberg D. PMID: 14654685; PMCID: PMC291866.
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    186. Structure of superoxide dismutase from Pyrobaculum aerophilum presents a challenging case in molecular replacement with multiple molecules, pseudo-symmetry and twinning. Acta Crystallogr D Biol Crystallogr. 2003 Dec; 59(Pt 12):2191-9. Lee S, Sawaya MR, Eisenberg D. PMID: 14646077.
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    187. Role of the C-terminal 28 residues of beta2-microglobulin in amyloid fibril formation. Biochemistry. 2003 Nov 25; 42(46):13536-40. Ivanova MI, Gingery M, Whitson LJ, Eisenberg D. PMID: 14622000.
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    188. Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis. J Biol Chem. 2004 Jan 30; 279(5):3516-24. Goulding CW, Apostol MI, Gleiter S, Parseghian A, Bardwell J, Gennaro M, Eisenberg D. PMID: 14597624.
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    189. The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12420-5. Hsu T, Hingley-Wilson SM, Chen B, Chen M, Dai AZ, Morin PM, Marks CB, Padiyar J, Goulding C, Gingery M, Eisenberg D, Russell RG, Derrick SC, Collins FM, Morris SL, King CH, Jacobs WR. PMID: 14557547; PMCID: PMC218773.
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    190. Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science. 2003 Sep 12; 301(5639):1527-30. Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M, Burdick A, Sarno EN, Wagner M, Röllinghoff M, Rea TH, Colonna M, Stenger S, Bloom BR, Eisenberg D, Modlin RL. PMID: 12970564.
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    191. The discovery of the alpha-helix and beta-sheet, the principal structural features of proteins. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11207-10. Eisenberg D. PMID: 12966187; PMCID: PMC208735.
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    192. Structural genomics of Mycobacterium tuberculosis: a preliminary report of progress at UCLA. Biophys Chem. 2003 Sep; 105(2-3):361-70. Goulding CW, Perry LJ, Anderson D, Sawaya MR, Cascio D, Apostol MI, Chan S, Parseghian A, Wang SS, Wu Y, Cassano V, Gill HS, Eisenberg D. PMID: 14499904.
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    193. Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach. Genome Biol. 2003; 4(9):R59. Strong M, Mallick P, Pellegrini M, Thompson MJ, Eisenberg D. PMID: 12952538; PMCID: PMC193659.
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    194. Seeded conversion of recombinant prion protein to a disulfide-bonded oligomer by a reduction-oxidation process. Nat Struct Biol. 2003 Sep; 10(9):725-30. Lee S, Eisenberg D. PMID: 12897768.
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    195. Cross-beta order and diversity in nanocrystals of an amyloid-forming peptide. J Mol Biol. 2003 Jul 25; 330(5):1165-75. Diaz-Avalos R, Long C, Fontano E, Balbirnie M, Grothe R, Eisenberg D, Caspar DL. PMID: 12860136.
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    196. Heterogeneity of molecular targets on clonal cancer lines derived from a novel hormone-refractory prostate cancer tumor system. Prostate. 2003 Jun 01; 55(4):299-307. Freedland SJ, Pantuck AJ, Paik SH, Zisman A, Graeber TG, Eisenberg D, McBride WH, Nguyen D, Tso CL, Belldegrun AS. PMID: 12712409.
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    197. Computational methods of analysis of protein-protein interactions. Curr Opin Struct Biol. 2003 Jun; 13(3):377-82. Salwinski L, Eisenberg D. PMID: 12831890.
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    198. Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate. Protein Sci. 2003 May; 12(5):1097-108. Wang S, Eisenberg D. PMID: 12717031; PMCID: PMC2323879.
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    199. Sharing publication-related data and materials: responsibilities of authorship in the life sciences. Plant Physiol. 2003 May; 132(1):19-24. Cech TR, Eddy SR, Eisenberg D, Hersey K, Holtzman SH, Poste GH, Raikhel NV, Scheller RH, Singer DB, Waltham MC, National Academics Committee on Responsibilities of Authorship in the Biological Sciences. PMID: 12746507; PMCID: PMC1540310.
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    200. The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs). Protein Sci. 2003 Apr; 12(4):832-47. Mura C, Kozhukhovsky A, Gingery M, Phillips M, Eisenberg D. PMID: 12649441; PMCID: PMC2323858.
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    201. Structure and assembly of an augmented Sm-like archaeal protein 14-mer. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4539-44. Mura C, Phillips M, Kozhukhovsky A, Eisenberg D. PMID: 12668760; PMCID: PMC404694.
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    202. Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity. J Mol Biol. 2003 Mar 07; 326(5):1559-75. Mura C, Katz JE, Clarke SG, Eisenberg D. PMID: 12595266.
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    203. Selective dimerization of a C2H2 zinc finger subfamily. Mol Cell. 2003 Feb; 11(2):459-70. McCarty AS, Kleiger G, Eisenberg D, Smale ST. PMID: 12620233.
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    204. Granulysin crystal structure and a structure-derived lytic mechanism. J Mol Biol. 2003 Jan 10; 325(2):355-65. Anderson DH, Sawaya MR, Cascio D, Ernst W, Modlin R, Krensky A, Eisenberg D. PMID: 12488100.
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    205. John T. Edsall as tutor and teacher. Biophys Chem. 2003; 100(1-3):91-3. Eisenberg D. PMID: 12646352.
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    206. The directional atomic solvation energy: an atom-based potential for the assignment of protein sequences to known folds. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16041-6. Mallick P, Weiss R, Eisenberg D. PMID: 12461172; PMCID: PMC138561.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    207. Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-A resolution. Protein Sci. 2002 Dec; 11(12):2887-93. Goulding CW, Parseghian A, Sawaya MR, Cascio D, Apostol MI, Gennaro ML, Eisenberg D. PMID: 12441386; PMCID: PMC2373750.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    208. GXXXG and GXXXA motifs stabilize FAD and NAD(P)-binding Rossmann folds through C(alpha)-H... O hydrogen bonds and van der waals interactions. J Mol Biol. 2002 Oct 11; 323(1):69-76. Kleiger G, Eisenberg D. PMID: 12368099.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    209. Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation. Biochemistry. 2002 Aug 06; 41(31):9863-72. Gill HS, Pfluegl GM, Eisenberg D. PMID: 12146952.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    210. Genomic evidence that the intracellular proteins of archaeal microbes contain disulfide bonds. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9679-84. Mallick P, Boutz DR, Eisenberg D, Yeates TO. PMID: 12107280; PMCID: PMC124975.
      View in: PubMed   Mentions: 63     Fields:    Translation:Cells
    211. Thiol-disulfide exchange in an immunoglobulin-like fold: structure of the N-terminal domain of DsbD. Biochemistry. 2002 Jun 04; 41(22):6920-7. Goulding CW, Sawaya MR, Parseghian A, Lim V, Eisenberg D, Missiakas D. PMID: 12033924.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    212. The TB structural genomics consortium: providing a structural foundation for drug discovery. Curr Drug Targets Infect Disord. 2002 Jun; 2(2):121-41. Goulding CW, Apostol M, Anderson DH, Gill HS, Smith CV, Kuo MR, Yang JK, Waldo GS, Suh SW, Chauhan R, Kale A, Bachhawat N, Mande SC, Johnston JM, Lott JS, Baker EN, Arcus VL, Leys D, McLean KJ, Munro AW, Berendzen J, Sharma V, Park MS, Eisenberg D, Sacchettini J, Alber T, Rupp B, Jacobs W, Terwilliger TC. PMID: 12462144.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    213. 3D domain swapping: as domains continue to swap. Protein Sci. 2002 Jun; 11(6):1285-99. Liu Y, Eisenberg D. PMID: 12021428; PMCID: PMC2373619.
      View in: PubMed   Mentions: 236     Fields:    Translation:HumansAnimalsCells
    214. A hierarchic approach to the design of hexameric helical barrels. J Mol Biol. 2002 May 24; 319(1):243-53. Ghirlanda G, Lear JD, Ogihara NL, Eisenberg D, DeGrado WF. PMID: 12051949.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    215. GXXXG and AXXXA: common alpha-helical interaction motifs in proteins, particularly in extremophiles. Biochemistry. 2002 May 14; 41(19):5990-7. Kleiger G, Grothe R, Mallick P, Eisenberg D. PMID: 11993993.
      View in: PubMed   Mentions: 82     Fields:    Translation:Cells
    216. Protein interactions: two methods for assessment of the reliability of high throughput observations. Mol Cell Proteomics. 2002 May; 1(5):349-56. Deane CM, Salwinski L, Xenarios I, Eisenberg D. PMID: 12118076.
      View in: PubMed   Mentions: 211     Fields:    Translation:AnimalsCells
    217. Structure of a Nudix protein from Pyrobaculum aerophilum reveals a dimer with two intersubunit beta-sheets. Acta Crystallogr D Biol Crystallogr. 2002 Apr; 58(Pt 4):571-8. Wang S, Mura C, Sawaya MR, Cascio D, Eisenberg D. PMID: 11914479.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    218. Structures of the two 3D domain-swapped RNase A trimers. Protein Sci. 2002 Feb; 11(2):371-80. Liu Y, Gotte G, Libonati M, Eisenberg D. PMID: 11790847; PMCID: PMC2373430.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    219. Describing biological protein interactions in terms of protein states and state transitions: the LiveDIP database. Mol Cell Proteomics. 2002 Feb; 1(2):104-16. Duan XJ, Xenarios I, Eisenberg D. PMID: 12096128.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    220. John T. Edsall and Advances in Protein Chemistry. Adv Protein Chem. 2002; 62:xi-xiv. Eisenberg DS, Kuriyan J, Richards FM. PMID: 12418097.
      View in: PubMed   Mentions: 1     Fields:    
    221. DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions. Nucleic Acids Res. 2002 Jan 01; 30(1):303-5. Xenarios I, Salwínski L, Duan XJ, Higney P, Kim SM, Eisenberg D. PMID: 11752321; PMCID: PMC99070.
      View in: PubMed   Mentions: 483     Fields:    Translation:HumansAnimalsCells
    222. Protein function in the post-genomic era. Nature. 2000 Jun 15; 405(6788):823-6. Eisenberg D, Marcotte EM, Xenarios I, Yeates TO. PMID: 10866208.
      View in: PubMed   Mentions: 179     Fields:    Translation:Animals
    223. Structure-function relationships of glutamine synthetases. Biochim Biophys Acta. 2000 Mar 07; 1477(1-2):122-45. Eisenberg D, Gill HS, Pfluegl GM, Rotstein SH. PMID: 10708854.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    224. How chaperones protect virgin proteins. Science. 1999 Aug 13; 285(5430):1021-2. Eisenberg D. PMID: 10475844.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
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