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NSC95397 Is a Novel HIV-1 Latency-Reversing Agent. Viruses. 2024 Nov 16; 16(11).
Nichols Doyle R, Yang V, Kayode YI, Damoiseaux R, Taylor HE, Fregoso OI. PMID: 39599897; PMCID: PMC11599149.
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HumansCells
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NSC95397 is a Novel HIV-1 Latency Reversing Agent. bioRxiv. 2024 Aug 26.
Doyle RN, Yang V, Kayode YI, Damoiseaux R, Taylor HE, Fregoso OI. PMID: 37293110; PMCID: PMC10245985.
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N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma. Cancer Res Commun. 2024 Jul 01; 4(7):1815-1833.
Geroyska S, Mejia I, Chan AA, Navarrete M, Pandey V, Kharpatin S, Noguti J, Wang F, Srole D, Chou TF, Wohlschlegel J, Nemeth E, Damoiseaux R, Shackelford DB, Lee DJ, Díaz B. PMID: 38949950; PMCID: PMC11270646.
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1 Fields:
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HumansAnimalsCells
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Expression of Concern: Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma. Cancer Discov. 2024 07 01; 14(7):1356.
Hong A, Moriceau G, Sun L, Lomeli S, Piva M, Damoiseaux R, Holmen SL, Sharpless NE, Hugo W, Lo RS. PMID: 38946327.
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Chemoproteomics Identifies State-Dependent and Proteoform-Selective Caspase-2 Inhibitors. J Am Chem Soc. 2024 Jun 05; 146(22):14972-14988.
Castellón JO, Ofori S, Burton NR, Julio AR, Turmon AC, Armenta E, Sandoval C, Boatner LM, Takayoshi EE, Faragalla M, Taylor C, Zhou AL, Tran K, Shek J, Yan T, Desai HS, Fregoso OI, Damoiseaux R, Backus KM. PMID: 38787738.
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2 Fields:
Translation:
HumansCells
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FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery. SLAS Discov. 2024 Apr; 29(3):100138.
Wang Y, Cortes E, Huang R, Wan J, Zhao J, Hinz B, Damoiseaux R, Pushkarsky I. PMID: 38158044.
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HumansCells
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Adaptation of the Tumor Antigen Presentation Machinery to Ionizing Radiation. J Immunol. 2023 08 15; 211(4):693-705.
Lee MH, Ratanachan D, Wang Z, Hack J, Adbulrahman L, Shamlin NP, Kalayjian M, Nesseler JP, Ganapathy E, Nguyen C, Ratikan JA, Cacalano NA, Austin D, Damoiseaux R, DiPardo BJ, Graham DS, Kalbasi A, Sayre JW, McBride WH, Schaue D. PMID: 37395687; PMCID: PMC10435044.
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PubMed Mentions:
1 Fields:
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HumansAnimalsCells
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MEK Inhibition Sensitizes Pancreatic Cancer to STING Agonism by Tumor Cell-intrinsic Amplification of Type I IFN Signaling. Clin Cancer Res. 2023 08 15; 29(16):3130-3141.
Ghukasyan R, Liang K, Chau K, Li L, Chan C, Abt ER, Le T, Park JY, Wu N, Premji A, Damoiseaux R, Luu T, Labora A, Rashid K, Link JM, Radu CG, Donahue TR. PMID: 37195712; PMCID: PMC10865884.
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2 Fields:
Translation:
HumansCells
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Comparative Analysis of Molecular Pathogenic Mechanisms and Antiviral Development Targeting Old and New World Hantaviruses. bioRxiv. 2023 Aug 05.
Jeyachandran AV, Irudayam JI, Dubey S, Chakravarty N, Konda B, Shah A, Su B, Wang C, Cui Q, Williams KJ, Srikanth S, Shi Y, Deb A, Damoiseaux R, Stripp BR, Ramaiah A, Arumugaswami V. PMID: 37577539; PMCID: PMC10418258.
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Osteopontin as a Biomarker in Chronic Kidney Disease. Biomedicines. 2023 May 04; 11(5).
Sinha SK, Mellody M, Carpio MB, Damoiseaux R, Nicholas SB. PMID: 37239027; PMCID: PMC10216241.
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PubMed Mentions:
10
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Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nat Commun. 2023 04 25; 14(1):2379.
Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS. PMID: 37185252; PMCID: PMC10127185.
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4 Fields:
Translation:
HumansCells
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Quantitative In Vivo Imaging of the Androgen Receptor Axis Reveals Degree of Prostate Cancer Radiotherapy Response. Mol Cancer Res. 2023 04 01; 21(4):307-315.
Storey CM, Altai M, Bicak M, Veach DR, Lückerath K, Adrian G, McDevitt MR, Kalidindi T, Park JE, Herrmann K, Abou D, Zedan W, Peekhaus N, Klein RJ, Damoiseaux R, Larson SM, Lilja H, Thorek D, Ulmert D. PMID: 36608299; PMCID: PMC10355285.
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HumansAnimalsCells
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Pacritinib inhibits glucose consumption in squamous cell lung cancer cells by targeting FLT3. Sci Rep. 2023 01 25; 13(1):1442.
Ghezzi C, Chen BY, Damoiseaux R, Clark PM. PMID: 36697489; PMCID: PMC9876922.
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1 Fields:
Translation:
HumansCells
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Early Reduction of Glucose Consumption Is a Biomarker of Kinase Inhibitor Efficacy Which Can Be Reversed with GLUT1 Overexpression in Lung Cancer Cells. Mol Imaging Biol. 2023 06; 25(3):541-553.
Ghezzi C, Perez S, Ryan K, Wong A, Chen BY, Damoiseaux R, Clark PM. PMID: 36284040; PMCID: PMC10732700.
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PubMed Mentions:
1 Fields:
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HumansCells
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A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2. J Biol Chem. 2022 08; 298(8):102228.
Scoles DR, Gandelman M, Paul S, Dexheimer T, Dansithong W, Figueroa KP, Pflieger LT, Redlin S, Kales SC, Sun H, Maloney D, Damoiseaux R, Henderson MJ, Simeonov A, Jadhav A, Pulst SM. PMID: 35787375; PMCID: PMC9356275.
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HumansCells
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Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models. J Vis Exp. 2022 06 16; (184).
Liang J, Sohrabi A, Epperson M, Rad LM, Tamura K, Sathialingam M, Skandakumar T, Lue P, Huang J, Popoli J, Yackly A, Bick M, Wang ZZ, Chen CC, Varuzhanyan G, Damoiseaux R, Seidlits SK. PMID: 35781280; PMCID: PMC9969841.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Best practices for reporting throughput in biomedical research. Nat Methods. 2022 06; 19(6):633-634.
Herbig M, Isozaki A, Di Carlo D, Guck J, Nitta N, Damoiseaux R, Kamikawaji S, Suyama E, Shintaku H, Wu AR, Nikaido I, Goda K. PMID: 35508736.
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3 Fields:
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Simplified, High-throughput Analysis of Single-cell Contractility using Micropatterned Elastomers. J Vis Exp. 2022 04 08; (182).
Hairapetian L, Cortes E, Zhao J, Wang Y, Huang R, Damoiseaux R, Pushkarsky I. PMID: 35467653.
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HumansCells
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Suspendable Hydrogel Nanovials for Massively Parallel Single-Cell Functional Analysis and Sorting. ACS Nano. 2022 05 24; 16(5):7242-7257.
de Rutte J, Dimatteo R, Archang MM, van Zee M, Koo D, Lee S, Sharrow AC, Krohl PJ, Mellody M, Zhu S, Eichenbaum JV, Kizerwetter M, Udani S, Ha K, Willson RC, Bertozzi AL, Spangler JB, Damoiseaux R, Di Carlo D. PMID: 35324146; PMCID: PMC9869715.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair. J Clin Invest. 2022 01 18; 132(2).
Li S, Yokota T, Wang P, Ten Hoeve J, Ma F, Le TM, Abt ER, Zhou Y, Wu R, Nanthavongdouangsy M, Rodriguez A, Wang Y, Lin YJ, Muranaka H, Sharpley M, Braddock DT, MacRae VE, Banerjee U, Chiou PY, Seldin M, Huang D, Teitell M, Gertsman I, Jung M, Bensinger SJ, Damoiseaux R, Faull K, Pellegrini M, Lusis AJ, Graeber TG, Radu CG, Deb A. PMID: 34813507; PMCID: PMC8759793.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells. Cell Rep. 2022 01 11; 38(2):110236.
Abt ER, Le TM, Dann AM, Capri JR, Poddar S, Lok V, Li L, Liang K, Creech AL, Rashid K, Kim W, Wu N, Cui J, Cho A, Lee HR, Rosser EW, Link JM, Czernin J, Wu TT, Damoiseaux R, Dawson DW, Donahue TR, Radu CG. PMID: 35021095; PMCID: PMC8893345.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry. Viruses. 2021 10 20; 13(11).
Luu AP, Yao Z, Ramachandran S, Azzopardi SA, Miles LA, Schneider WM, Hoffmann HH, Bozzacco L, Garcia G, Gong D, Damoiseaux R, Tang H, Morizono K, Rudin CM, Sun R, Arumugaswami V, Poirier JT, MacDonald MR, Rice CM, Li MMH. PMID: 34834920; PMCID: PMC8623001.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. Proc Natl Acad Sci U S A. 2021 10 19; 118(42).
Liu X, Verma A, Garcia G, Ramage H, Lucas A, Myers RL, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. PMID: 34593624; PMCID: PMC8594528.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition. medRxiv. 2021 Jul 21.
Liu X, Verma A, Garcia G, Ramage H, Myers RL, Lucas A, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. PMID: 33655282; PMCID: PMC7924307.
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Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples. Nat Biomed Eng. 2021 07; 5(7):657-665.
Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Sina Booeshaghi A, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. PMID: 34211145; PMCID: PMC10810734.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Classes of Drugs that Mitigate Radiation Syndromes. Front Pharmacol. 2021; 12:666776.
Micewicz ED, Damoiseaux RD, Deng G, Gomez A, Iwamoto KS, Jung ME, Nguyen C, Norris AJ, Ratikan JA, Ruchala P, Sayre JW, Schaue D, Whitelegge JP, McBride WH. PMID: 34084139; PMCID: PMC8167044.
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PubMed Mentions:
4
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DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division. J Biol Chem. 2021 Jan-Jun; 296:100676.
Guo X, Ramirez I, Garcia YA, Velasquez EF, Gholkar AA, Cohn W, Whitelegge JP, Tofig B, Damoiseaux R, Torres JZ. PMID: 33865857; PMCID: PMC8131738.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition. Nat Commun. 2021 03 25; 12(1):1876.
Mullen PJ, Garcia G, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. PMID: 33767183; PMCID: PMC7994801.
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PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
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Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication. Cell Rep. 2021 04 06; 35(1):108940.
Garcia G, Sharma A, Ramaiah A, Sen C, Purkayastha A, Kohn DB, Parcells MS, Beck S, Kim H, Bakowski MA, Kirkpatrick MG, Riva L, Wolff KC, Han B, Yuen C, Ulmert D, Purbey PK, Scumpia P, Beutler N, Rogers TF, Chatterjee AK, Gabriel G, Bartenschlager R, Gomperts B, Svendsen CN, Betz UAK, Damoiseaux RD, Arumugaswami V. PMID: 33784499; PMCID: PMC7969873.
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PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
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Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. bioRxiv. 2021 Mar 18.
Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS. PMID: 33688654; PMCID: PMC7941625.
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PubMed Mentions:
2
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Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing. medRxiv. 2021 Mar 09.
Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Booeshaghi AS, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. PMID: 32909008; PMCID: PMC7480060.
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PubMed Mentions:
2
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The myosin regulatory light chain Myl5 localizes to mitotic spindle poles and is required for proper cell division. Cytoskeleton (Hoboken). 2021 02; 78(2):23-35.
Ramirez I, Gholkar AA, Velasquez EF, Guo X, Tofig B, Damoiseaux R, Torres JZ. PMID: 33641240; PMCID: PMC8722072.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates. Clin Cancer Res. 2021 04 01; 27(7):2050-2060.
Veach DR, Storey CM, Lückerath K, Braun K, von Bodman C, Lamminmäki U, Kalidindi T, Strand SE, Strand J, Altai M, Damoiseaux R, Zanzonico P, Benabdallah N, Pankov D, Scher HI, Scardino P, Larson SM, Lilja H, McDevitt MR, Thorek DLJ, Ulmert D. PMID: 33441295; PMCID: PMC8278668.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Commercial immunoglobulin products contain cross-reactive but not neutralizing antibodies against SARS-CoV-2. J Allergy Clin Immunol. 2021 03; 147(3):876-877.
Ahn TS, Han B, Krogstad P, Bun C, Kohn LA, Garcia-Lloret MI, Damoiseaux R, Butte MJ. PMID: 33358557; PMCID: PMC7833834.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington's disease patients. Sci Rep. 2020 11 20; 10(1):20295.
Lee CYD, Wang N, Shen K, Stricos M, Langfelder P, Cheon KH, Cortés EP, Vinters HV, Vonsattel JP, Wexler NS, Damoiseaux R, Frydman J, Yang XW. PMID: 33219289; PMCID: PMC7679413.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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A High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier. Cancer Res. 2021 02 01; 81(3):619-633.
Hilfenhaus G, Mompeón A, Freshman J, Prajapati DP, Hernandez G, Freitas VM, Ma F, Langenbacher AD, Mirkov S, Song D, Cho BK, Goo YA, Pellegrini M, Chen JN, Damoiseaux R, Iruela-Arispe ML. PMID: 33218969; PMCID: PMC7916904.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy. Cell Rep Med. 2020 10 20; 1(7):100122.
Liu J, Campagna J, John V, Damoiseaux R, Mokhonova E, Becerra D, Meng H, McNally EM, Pyle AD, Kramerova I, Spencer MJ. PMID: 33205074; PMCID: PMC7659555.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma. Sci Transl Med. 2020 10 14; 12(565).
Kalbasi A, Tariveranmoshabad M, Hakimi K, Kremer S, Campbell KM, Funes JM, Vega-Crespo A, Parisi G, Champekar A, Nguyen C, Torrejon D, Shin D, Zaretsky JM, Damoiseaux RD, Speiser DE, Lopez-Casas PP, Quintero M, Ribas A. PMID: 33055240; PMCID: PMC8053376.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy. Skelet Muscle. 2020 09 18; 10(1):26.
Shu C, Parfenova L, Mokhonova E, Collado JR, Damoiseaux R, Campagna J, John V, Crosbie RH. PMID: 32948250; PMCID: PMC7499884.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma. Cancer Lett. 2020 10 28; 491:97-107.
Liu SH, Yu J, Creeden JF, Sutton JM, Markowiak S, Sanchez R, Nemunaitis J, Kalinoski A, Zhang JT, Damoiseaux R, Erhardt P, Brunicardi FC. PMID: 32829010; PMCID: PMC8766172.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy. Proc Natl Acad Sci U S A. 2020 06 30; 117(26):15172-15181.
Bicak M, Lückerath K, Kalidindi T, Phelps ME, Strand SE, Morris MJ, Radu CG, Damoiseaux R, Peltola MT, Peekhaus N, Ho A, Veach D, Malmborg Hager AC, Larson SM, Lilja H, McDevitt MR, Klein RJ, Ulmert D. PMID: 32532924; PMCID: PMC7334567.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
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Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nat Immunol. 2020 07; 21(7):746-755.
Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. PMID: 32514064; PMCID: PMC7778040.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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A Cell-based Screen in Actinomyces oris to Identify Sortase Inhibitors. Sci Rep. 2020 05 22; 10(1):8520.
Gosschalk JE, Chang C, Sue CK, Siegel SD, Wu C, Kattke MD, Yi SW, Damoiseaux R, Jung ME, Ton-That H, Clubb RT. PMID: 32444661; PMCID: PMC7244523.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):11085-11096.
Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 32358191; PMCID: PMC7245100.
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PubMed Mentions:
22 Fields:
Translation:
Animals
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Mitigation of aflatoxin B1- and sodium arsenite-induced cytotoxicities in HUC-PC urinary bladder cells by curcumin and Khaya senegalensis. J Basic Clin Physiol Pharmacol. 2020 Apr 22; 31(4).
Olugbami JO, Damoiseaux R, Odunola OA, Gimzewski JK. PMID: 32324162.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias. RSC Med Chem. 2020 Mar 01; 11(3):392-410.
Sun DL, Poddar S, Pan RD, Rosser EW, Abt ER, Van Valkenburgh J, Le TM, Lok V, Hernandez SP, Song J, Li J, Turlik A, Chen X, Cheng CA, Chen W, Mona CE, Stuparu AD, Vergnes L, Reue K, Damoiseaux R, Zink JI, Czernin J, Donahue TR, Houk KN, Jung ME, Radu CG. PMID: 33479645; PMCID: PMC7593890.
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PubMed Mentions:
3
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High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis. Cell Rep. 2020 02 18; 30(7):2055-2064.e5.
Aros CJ, Paul MK, Pantoja CJ, Bisht B, Meneses LK, Vijayaraj P, Sandlin JM, France B, Tse JA, Chen MW, Shia DW, Rickabaugh TM, Damoiseaux R, Gomperts BN. PMID: 32075752; PMCID: PMC7050206.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Development of a high-throughput screen to identify small molecule enhancers of sarcospan for the treatment of Duchenne muscular dystrophy. Skelet Muscle. 2019 12 12; 9(1):32.
Shu C, Kaxon-Rupp AN, Collado JR, Damoiseaux R, Crosbie RH. PMID: 31831063; PMCID: PMC6907331.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Cell Rep. 2019 12 10; 29(11):3488-3505.e9.
Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros CJ, Ahadome SD, Shia DW, Chung K, Sandlin JM, Darmawan KF, Bhatt KV, Manze CC, Paul MK, Wilkinson DC, Yan W, Clark AT, Rickabaugh TM, Wallace WD, Graeber TG, Damoiseaux R, Gomperts BN. PMID: 31825831; PMCID: PMC6927560.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression. Cell Rep. 2019 Dec 10; 29(11):3766.
Garcia-Diaz A, Shin DS, Moreno BH, Saco J, Escuin-Ordinas H, Rodriguez GA, Zaretsky JM, Sun L, Hugo W, Wang X, Parisi G, Saus CP, Torrejon DY, Graeber TG, Comin-Anduix B, Hu-Lieskovan S, Damoiseaux R, Lo RS, Ribas A. PMID: 31825850.
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PubMed Mentions:
58 Fields:
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A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells. Nat Commun. 2019 11 29; 10(1):5444.
Ghezzi C, Wong A, Chen BY, Ribalet B, Damoiseaux R, Clark PM. PMID: 31784510; PMCID: PMC6884612.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism. Cell Chem Biol. 2020 02 20; 27(2):197-205.e6.
Abt ER, Rosser EW, Durst MA, Lok V, Poddar S, Le TM, Cho A, Kim W, Wei L, Song J, Capri JR, Xu S, Wu N, Slavik R, Jung ME, Damoiseaux R, Czernin J, Donahue TR, Lavie A, Radu CG. PMID: 31734178; PMCID: PMC7035983.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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An in situ high-throughput screen identifies inhibitors of intracellular Burkholderia pseudomallei with therapeutic efficacy. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18597-18606.
Bulterys PL, Toesca IJ, Norris MH, Maloy JP, Fitz-Gibbon ST, France B, Toffig B, Morselli M, Somprasong N, Pellegrini M, Schweizer HP, Tuanyok A, Damoiseaux R, French CT, Miller JF. PMID: 31439817; PMCID: PMC6744847.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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PTPσ inhibitors promote hematopoietic stem cell regeneration. Nat Commun. 2019 08 14; 10(1):3667.
Zhang Y, Roos M, Himburg H, Termini CM, Quarmyne M, Li M, Zhao L, Kan J, Fang T, Yan X, Pohl K, Diers E, Jin Gim H, Damoiseaux R, Whitelegge J, McBride W, Jung ME, Chute JP. PMID: 31413255; PMCID: PMC6694155.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Leukemia Cell Cycle Chemical Profiling Identifies the G2-Phase Leukemia Specific Inhibitor Leusin-1. ACS Chem Biol. 2019 05 17; 14(5):994-1001.
Xia X, Lo YC, Gholkar AA, Senese S, Ong JY, Velasquez EF, Damoiseaux R, Torres JZ. PMID: 31046221; PMCID: PMC6884739.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):9959-9968.
Mognol GP, González-Avalos E, Ghosh S, Spreafico R, Gudlur A, Rao A, Damoiseaux R, Hogan PG. PMID: 31019078; PMCID: PMC6525529.
View in:
PubMed Mentions:
18 Fields:
Translation:
Cells
-
A simple high-throughput approach identifies actionable drug sensitivities in patient-derived tumor organoids. Commun Biol. 2019; 2:78.
Phan N, Hong JJ, Tofig B, Mapua M, Elashoff D, Moatamed NA, Huang J, Memarzadeh S, Damoiseaux R, Soragni A. PMID: 30820473; PMCID: PMC6389967.
View in:
PubMed Mentions:
120 Translation:
Humans
-
The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation. Radiat Res. 2019 04; 191(4):323-334.
Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. PMID: 30730284; PMCID: PMC6482953.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsPHPublic Health
-
A scalable filtration method for high throughput screening based on cell deformability. Lab Chip. 2019 01 15; 19(2):343-357.
Gill NK, Ly C, Nyberg KD, Lee L, Qi D, Tofig B, Reis-Sobreiro M, Dorigo O, Rao J, Wiedemeyer R, Karlan B, Lawrenson K, Freeman MR, Damoiseaux R, Rowat AC. PMID: 30566156.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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1-(4-nitrobenzenesulfonyl)-4-penylpiperazine increases the number of Peyer's patch-associated regenerating crypts in the small intestines after radiation injury. Radiother Oncol. 2019 03; 132:8-15.
Bhat K, Duhachek-Muggy S, Ramanathan R, Saki M, Alli C, Medina P, Damoiseaux R, Whitelegge J, McBride WH, Schaue D, Vlashi E, Pajonk F. PMID: 30825974; PMCID: PMC6400303.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsPHPublic Health
-
A Gelatin Microdroplet Platform for High-Throughput Sorting of Hyperproducing Single-Cell-Derived Microalgal Clones. Small. 2018 11; 14(44):e1803315.
Li M, van Zee M, Riche CT, Tofig B, Gallaher SD, Merchant SS, Damoiseaux R, Goda K, Di Carlo D. PMID: 30369052.
View in:
PubMed Mentions:
15 Fields:
-
Prevalence and patterns of higher-order drug interactions in Escherichia coli. NPJ Syst Biol Appl. 2018; 4:31.
Tekin E, White C, Kang TM, Singh N, Cruz-Loya M, Damoiseaux R, Savage VM, Yeh PJ. PMID: 30181902; PMCID: PMC6119685.
View in:
PubMed Mentions:
39 Fields:
-
Stressor interaction networks suggest antibiotic resistance co-opted from stress responses to temperature. ISME J. 2019 01; 13(1):12-23.
Cruz-Loya M, Kang TM, Lozano NA, Watanabe R, Tekin E, Damoiseaux R, Savage VM, Yeh PJ. PMID: 30171253; PMCID: PMC6298959.
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PubMed Mentions:
28 Fields:
Translation:
Cells
-
Obesity increases airway smooth muscle responses to contractile agonists. Am J Physiol Lung Cell Mol Physiol. 2018 11 01; 315(5):L673-L681.
Orfanos S, Jude J, Deeney BT, Cao G, Rastogi D, van Zee M, Pushkarsky I, Munoz HE, Damoiseaux R, Di Carlo D, Panettieri RA. PMID: 30160518; PMCID: PMC6295505.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansCells
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A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer Metab. 2018; 6:7.
Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. PMID: 29988332; PMCID: PMC6022704.
View in:
PubMed Mentions:
15
-
A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma. Neuro Oncol. 2018 05 18; 20(6):764-775.
Laks DR, Oses-Prieto JA, Alvarado AG, Nakashima J, Chand S, Azzam DB, Gholkar AA, Sperry J, Ludwig K, Condro MC, Nazarian S, Cardenas A, Shih MYS, Damoiseaux R, France B, Orozco N, Visnyei K, Crisman TJ, Gao F, Torres JZ, Coppola G, Burlingame AL, Kornblum HI. PMID: 29136244; PMCID: PMC5961175.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Publisher Correction: Elastomeric sensor surfaces for high-throughput single-cell force cytometry. Nat Biomed Eng. 2018 Apr; 2(4):265.
Pushkarsky I, Tseng P, Black D, France B, Warfe L, Koziol-White CJ, Jester WF, Trinh RK, Lin J, Scumpia PO, Morrison SL, Panettieri RA, Damoiseaux R, Di Carlo D. PMID: 31015734.
View in:
PubMed Mentions:
1 Fields:
-
Elastomeric sensor surfaces for high-throughput single-cell force cytometry. Nat Biomed Eng. 2018 02; 2(2):124-137.
Pushkarsky I, Tseng P, Black D, France B, Warfe L, Koziol-White CJ, Jester WF, Trinh RK, Lin J, Scumpia PO, Morrison SL, Panettieri RA, Damoiseaux R, Di Carlo D. PMID: 31015629; PMCID: PMC6619436.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Making It All Work: Functional Genomics and Reporter Gene Assays. Methods Mol Biol. 2018; 1755:89-105.
Welch G, Damoiseaux R, Miraglia L. PMID: 29671265.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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The Use of Somatic Hypermutation for the Affinity Maturation of Therapeutic Antibodies. Methods Mol Biol. 2018; 1827:479-489.
Bowers PM, Boyle WJ, Damoiseaux R. PMID: 30196512; PMCID: PMC6497467.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Reporter Gene Assays Using Transfectable Functional Genomics Libraries. Methods Mol Biol. 2018; 1755:107-120.
Welch G, Damoiseaux R, Miraglia L. PMID: 29671266.
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PubMed Mentions: Fields:
Translation:
HumansCells
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High-Throughput Screening of a Luciferase Reporter of Gene Silencing on the Inactive X Chromosome. Methods Mol Biol. 2018; 1755:75-87.
Keegan A, Plath K, Damoiseaux R. PMID: 29671264.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Gα12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner. Br J Pharmacol. 2017 Dec; 174(23):4383-4395.
Yoo EJ, Cao G, Koziol-White CJ, Ojiaku CA, Sunder K, Jude JA, Michael JV, Lam H, Pushkarsky I, Damoiseaux R, Di Carlo D, Ahn K, An SS, Penn RB, Panettieri RA. PMID: 28921504; PMCID: PMC5715591.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
-
Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation. Oncotarget. 2017 Nov 28; 8(61):104007-104021.
Senese S, Lo YC, Gholkar AA, Li CM, Huang Y, Mottahedeh J, Kornblum HI, Damoiseaux R, Torres JZ. PMID: 29262617; PMCID: PMC5732783.
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PubMed Mentions:
3 Fields:
-
Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 2017 Oct 10; 21(2):517-532.
Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. PMID: 29020636; PMCID: PMC5637483.
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PubMed Mentions:
194 Fields:
Translation:
HumansCells
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Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma. Cancer Discov. 2018 01; 8(1):74-93.
Hong A, Moriceau G, Sun L, Lomeli S, Piva M, Damoiseaux R, Holmen SL, Sharpless NE, Hugo W, Lo RS. PMID: 28923912; PMCID: PMC6456057.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimals
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Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential. Sci Rep. 2017 09 12; 7(1):11261.
Lo YC, Senese S, France B, Gholkar AA, Damoiseaux R, Torres JZ. PMID: 28900159; PMCID: PMC5595967.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Recurrent Tumor Cell-Intrinsic and -Extrinsic Alterations during MAPKi-Induced Melanoma Regression and Early Adaptation. Cancer Discov. 2017 11; 7(11):1248-1265.
Song C, Piva M, Sun L, Hong A, Moriceau G, Kong X, Zhang H, Lomeli S, Qian J, Yu CC, Damoiseaux R, Kelley MC, Dahlman KB, Scumpia PO, Sosman JA, Johnson DB, Ribas A, Hugo W, Lo RS. PMID: 28864476; PMCID: PMC6668729.
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PubMed Mentions:
83 Fields:
Translation:
HumansAnimalsCells
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A comparative assessment of antiproliferative properties of resveratrol and ethanol leaf extract of Anogeissus leiocarpus (DC) Guill and Perr against HepG2 hepatocarcinoma cells. BMC Complement Altern Med. 2017 Aug 02; 17(1):381.
Olugbami JO, Damoiseaux R, France B, Onibiyo EM, Gbadegesin MA, Sharma S, Gimzewski JK, Odunola OA. PMID: 28768515; PMCID: PMC5541659.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues. PLoS One. 2017; 12(7):e0181577.
Micewicz ED, Kim K, Iwamoto KS, Ratikan JA, Cheng G, Boxx GM, Damoiseaux RD, Whitelegge JP, Ruchala P, Nguyen C, Purbey P, Loo J, Deng G, Jung ME, Sayre JW, Norris AJ, Schaue D, McBride WH. PMID: 28732024; PMCID: PMC5521796.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCellsPHPublic Health
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Direct quantification of gamma H2AX by cell-based high throughput screening for evaluation of genotoxicity of pesticides in a human thyroid cell lines. Environ Mol Mutagen. 2017 08; 58(7):522-528.
Hershman JM, France B, Hon K, Damoiseaux R. PMID: 28640454; PMCID: PMC6550478.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression. Cell Rep. 2017 05 09; 19(6):1189-1201.
Garcia-Diaz A, Shin DS, Moreno BH, Saco J, Escuin-Ordinas H, Rodriguez GA, Zaretsky JM, Sun L, Hugo W, Wang X, Parisi G, Saus CP, Torrejon DY, Graeber TG, Comin-Anduix B, Hu-Lieskovan S, Damoiseaux R, Lo RS, Ribas A. PMID: 28494868; PMCID: PMC6420824.
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PubMed Mentions:
892 Fields:
Translation:
HumansCells
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When more is less: Emergent suppressive interactions in three-drug combinations. BMC Microbiol. 2017 05 06; 17(1):107.
Beppler C, Tekin E, White C, Mao Z, Miller JH, Damoiseaux R, Savage VM, Yeh PJ. PMID: 28477626; PMCID: PMC5420147.
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PubMed Mentions:
13 Fields:
Translation:
Cells
-
Atomic force microscopy correlates antimetastatic potentials of HepG2 cell line with its redox/energy status: effects of curcumin and Khaya senegalensis. J Integr Med. 2017 05; 15(3):214-230.
Olugbami JO, Damoiseaux R, France B, Gbadegesin MA, Stieg AZ, Sharma S, Odunola OA, Gimzewski JK. PMID: 28494852; PMCID: PMC6497468.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31; 292(13):5429-5442.
Miyata N, Tang Z, Conti MA, Johnson ME, Douglas CJ, Hasson SA, Damoiseaux R, Chang CA, Koehler CM. PMID: 28167535; PMCID: PMC5392686.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Engineering a Thermostable Keto Acid Decarboxylase Using Directed Evolution and Computationally Directed Protein Design. ACS Synth Biol. 2017 04 21; 6(4):610-618.
Soh LMJ, Mak WS, Lin PP, Mi L, Chen FY, Damoiseaux R, Siegel JB, Liao JC. PMID: 28052191.
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PubMed Mentions:
7 Fields:
Translation:
Cells
-
Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner. Br J Pharmacol. 2016 09; 173(18):2726-38.
Koziol-White CJ, Yoo EJ, Cao G, Zhang J, Papanikolaou E, Pushkarsky I, Andrews A, Himes BE, Damoiseaux RD, Liggett SB, Di Carlo D, Kurten RC, Panettieri RA. PMID: 27352269; PMCID: PMC4995285.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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3D Chemical Similarity Networks for Structure-Based Target Prediction and Scaffold Hopping. ACS Chem Biol. 2016 08 19; 11(8):2244-53.
Lo YC, Senese S, Damoiseaux R, Torres JZ. PMID: 27285961; PMCID: PMC5511031.
View in:
PubMed Mentions:
18 Fields:
Translation:
Cells
-
Copper status of exposed microorganisms influences susceptibility to metallic nanoparticles. Environ Toxicol Chem. 2016 May; 35(5):1148-58.
Reyes VC, Spitzmiller MR, Hong-Hermesdorf A, Kropat J, Damoiseaux RD, Merchant SS, Mahendra S. PMID: 26387648; PMCID: PMC5439594.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Characterization and evolution of an activator-independent methanol dehydrogenase from Cupriavidus necator N-1. Appl Microbiol Biotechnol. 2016 Jun; 100(11):4969-83.
Wu TY, Chen CT, Liu JT, Bogorad IW, Damoiseaux R, Liao JC. PMID: 26846745.
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PubMed Mentions:
30 Fields:
Translation:
Cells
-
Discovery of Structurally Diverse Small-Molecule Compounds with Broad Antiviral Activity against Enteroviruses. Antimicrob Agents Chemother. 2015 Dec 28; 60(3):1615-26.
Zuo J, Kye S, Quinn KK, Cooper P, Damoiseaux R, Krogstad P. PMID: 26711750; PMCID: PMC4775951.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2'-dC upon inhibition of ribonucleotide reductase. Epigenetics Chromatin. 2015; 8:42.
Minkovsky A, Sahakyan A, Bonora G, Damoiseaux R, Dimitrova E, Rubbi L, Pellegrini M, Radu CG, Plath K. PMID: 26468331; PMCID: PMC4604769.
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PubMed Mentions:
24 Fields:
-
Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening. J Virol. 2015 Aug; 89(16):8428-43.
Rathbun JY, Droniou ME, Damoiseaux R, Haworth KG, Henley JE, Exline CM, Choe H, Cannon PM. PMID: 26041296; PMCID: PMC4524252.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression. PLoS One. 2015; 10(4):e0122442.
Huynh TP, Barwe SP, Lee SJ, McSpadden R, Franco OE, Hayward SW, Damoiseaux R, Grubbs SS, Petrelli NJ, Rajasekaran AK. PMID: 25836370; PMCID: PMC4383530.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Large-scale chemical similarity networks for target profiling of compounds identified in cell-based chemical screens. PLoS Comput Biol. 2015 Mar; 11(3):e1004153.
Lo YC, Senese S, Li CM, Hu Q, Huang Y, Damoiseaux R, Torres JZ. PMID: 25826798; PMCID: PMC4380459.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1. PLoS One. 2015; 10(3):e0121833.
Ting PY, Damoiseaux R, Titz B, Bradley KA, Graeber TG, Fernández-Vega V, Bannister TD, Chase P, Nair R, Scampavia L, Hodder P, Spicer TP, Colicelli J. PMID: 25811598; PMCID: PMC4374917.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Comprehensive assessment of germline chemical toxicity using the nematode Caenorhabditis elegans. J Vis Exp. 2015 Feb 22; (96).
Parodi DA, Damoiseaux R, Allard P. PMID: 25741987; PMCID: PMC4354655.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Cytolethal distending toxins require components of the ER-associated degradation pathway for host cell entry. PLoS Pathog. 2014 Jul; 10(7):e1004295.
Eshraghi A, Dixon SD, Tamilselvam B, Kim EJ, Gargi A, Kulik JC, Damoiseaux R, Blanke SR, Bradley KA. PMID: 25078082; PMCID: PMC4117610.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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UCLA's Molecular Screening Shared Resource: enhancing small molecule discovery with functional genomics and new technology. Comb Chem High Throughput Screen. 2014 May; 17(4):356-68.
Damoiseaux R. PMID: 24661210.
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PubMed Mentions:
4 Fields:
-
Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 01; 192(1):110-22.
Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y. PMID: 24307733; PMCID: PMC3874217.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):E4904-12.
Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA. PMID: 24191014; PMCID: PMC3864319.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2013 Nov; 136(1):107-19.
Solaimani P, Damoiseaux R, Hankinson O. PMID: 23997114; PMCID: PMC3829574.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem. 2013 Sep 12; 56(17):6696-708.
Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. PMID: 23947754; PMCID: PMC3789385.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep; 21(9):1653-60.
Du L, Jung ME, Damoiseaux R, Completo G, Fike F, Ku JM, Nahas S, Piao C, Hu H, Gatti RA. PMID: 23774824; PMCID: PMC3776636.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Genome Res. 2013 Jun; 23(6):998-1007.
Zheng S, Damoiseaux R, Chen L, Black DL. PMID: 23636947; PMCID: PMC3668367.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15; 25(1):81-92.
Dabir DV, Hasson SA, Setoguchi K, Johnson ME, Wongkongkathep P, Douglas CJ, Zimmerman J, Damoiseaux R, Teitell MA, Koehler CM. PMID: 23597483; PMCID: PMC3726224.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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High-throughput screening of small molecules identifies hepcidin antagonists. Mol Pharmacol. 2013 Mar; 83(3):681-90.
Fung E, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E. PMID: 23292796; PMCID: PMC3583499.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Dantrolene enhances antisense-mediated exon skipping in human and mouse models of Duchenne muscular dystrophy. Sci Transl Med. 2012 Dec 12; 4(164):164ra160.
Kendall GC, Mokhonova EI, Moran M, Sejbuk NE, Wang DW, Silva O, Wang RT, Martinez L, Lu QL, Damoiseaux R, Spencer MJ, Nelson SF, Miceli MC. PMID: 23241744.
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PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
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Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1. Small. 2013 May 27; 9(9-10):1776-85.
Lin S, Zhao Y, Ji Z, Ear J, Chang CH, Zhang H, Low-Kam C, Yamada K, Meng H, Wang X, Liu R, Pokhrel S, Mädler L, Damoiseaux R, Xia T, Godwin HA, Lin S, Nel AE. PMID: 23180726; PMCID: PMC4034474.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Genome-wide assessment in Escherichia coli reveals time-dependent nanotoxicity paradigms. ACS Nano. 2012 Nov 27; 6(11):9402-15.
Reyes VC, Li M, Hoek EM, Mahendra S, Damoiseaux R. PMID: 23039911.
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PubMed Mentions:
9 Fields:
Translation:
Cells
-
Size influences the cytotoxicity of poly (lactic-co-glycolic acid) (PLGA) and titanium dioxide (TiO(2)) nanoparticles. Arch Toxicol. 2013 Jun; 87(6):1075-86.
Xiong S, George S, Yu H, Damoiseaux R, France B, Ng KW, Loo JS. PMID: 22983807; PMCID: PMC5657381.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Size of TiO(2) nanoparticles influences their phototoxicity: an in vitro investigation. Arch Toxicol. 2013 Jan; 87(1):99-109.
Xiong S, George S, Ji Z, Lin S, Yu H, Damoiseaux R, France B, Ng KW, Loo SC. PMID: 22885792; PMCID: PMC5889301.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal. Toxicol Appl Pharmacol. 2012 Sep 15; 263(3):303-14.
Tsirulnikov K, Abuladze N, Bragin A, Faull K, Cascio D, Damoiseaux R, Schibler MJ, Pushkin A. PMID: 22819785; PMCID: PMC5575769.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Fluoxetine is a potent inhibitor of coxsackievirus replication. Antimicrob Agents Chemother. 2012 Sep; 56(9):4838-44.
Zuo J, Quinn KK, Kye S, Cooper P, Damoiseaux R, Krogstad P. PMID: 22751539; PMCID: PMC3421851.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Quantitative detection of PfHRP2 in saliva of malaria patients in the Philippines. Malar J. 2012 May 25; 11:175.
Fung AO, Damoiseaux R, Grundeen S, Panes JL, Horton DH, Judy JW, Moore TB. PMID: 22631858; PMCID: PMC3422183.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano. 2012 May 22; 6(5):4349-68.
Zhang H, Ji Z, Xia T, Meng H, Low-Kam C, Liu R, Pokhrel S, Lin S, Wang X, Liao YP, Wang M, Li L, Rallo R, Damoiseaux R, Telesca D, Mädler L, Cohen Y, Zink JI, Nel AE. PMID: 22502734; PMCID: PMC4139054.
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PubMed Mentions:
208 Fields:
Translation:
Animals
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Automated phenotype recognition for zebrafish embryo based in vivo high throughput toxicity screening of engineered nano-materials. PLoS One. 2012; 7(4):e35014.
Liu R, Lin S, Rallo R, Zhao Y, Damoiseaux R, Xia T, Lin S, Nel A, Cohen Y. PMID: 22506062; PMCID: PMC3323610.
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PubMed Mentions:
17 Fields:
Translation:
Animals
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Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. Mol Cancer Ther. 2012 Jun; 11(6):1320-31.
Tai S, Sun Y, Liu N, Ding B, Hsia E, Bhuta S, Thor RK, Damoiseaux R, Liang C, Huang J. PMID: 22491797; PMCID: PMC3374015.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Genome-wide bacterial toxicity screening uncovers the mechanisms of toxicity of a cationic polystyrene nanomaterial. Environ Sci Technol. 2012 Feb 21; 46(4):2398-405.
Ivask A, Suarez E, Patel T, Boren D, Ji Z, Holden P, Telesca D, Damoiseaux R, Bradley KA, Godwin H. PMID: 22148163.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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Synergistic bactericidal activity of Ag-TiO₂ nanoparticles in both light and dark conditions. Environ Sci Technol. 2011 Oct 15; 45(20):8989-95.
Li M, Noriega-Trevino ME, Nino-Martinez N, Marambio-Jones C, Wang J, Damoiseaux R, Ruiz F, Hoek EM. PMID: 21866941.
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PubMed Mentions:
28 Fields:
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Seeing the light: luminescent reporter gene assays. Comb Chem High Throughput Screen. 2011 Sep; 14(8):648-57.
Miraglia LJ, King FJ, Damoiseaux R. PMID: 21564017.
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PubMed Mentions:
13 Fields:
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High content screening in zebrafish speeds up hazard ranking of transition metal oxide nanoparticles. ACS Nano. 2011 Sep 27; 5(9):7284-95.
Lin S, Zhao Y, Xia T, Meng H, Ji Z, Liu R, George S, Xiong S, Wang X, Zhang H, Pokhrel S, Mädler L, Damoiseaux R, Lin S, Nel AE. PMID: 21851096; PMCID: PMC4136441.
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PubMed Mentions:
48 Fields:
Translation:
Animals
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A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. Mol Cancer Ther. 2011 Oct; 10(10):1818-28.
Visnyei K, Onodera H, Damoiseaux R, Saigusa K, Petrosyan S, De Vries D, Ferrari D, Saxe J, Panosyan EH, Masterman-Smith M, Mottahedeh J, Bradley KA, Huang J, Sabatti C, Nakano I, Kornblum HI. PMID: 21859839; PMCID: PMC3191241.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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High throughput screening of small molecule libraries for modifiers of radiation responses. Int J Radiat Biol. 2011 Aug; 87(8):839-45.
Kim K, Damoiseaux R, Norris AJ, Rivina L, Bradley K, Jung ME, Gatti RA, Schiestl RH, McBride WH. PMID: 21401317; PMCID: PMC3203687.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Differential expression of syndecan-1 mediates cationic nanoparticle toxicity in undifferentiated versus differentiated normal human bronchial epithelial cells. ACS Nano. 2011 Apr 26; 5(4):2756-2769.
Zhang H, Xia T, Meng H, Xue M, George S, Ji Z, Wang X, Liu R, Wang M, France B, Rallo R, Damoiseaux R, Cohen Y, Bradley KA, Zink JI, Nel AE. PMID: 21366263; PMCID: PMC3896548.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials. ACS Nano. 2011 Mar 22; 5(3):1805-17.
George S, Xia T, Rallo R, Zhao Y, Ji Z, Lin S, Wang X, Zhang H, France B, Schoenfeld D, Damoiseaux R, Liu R, Lin S, Bradley KA, Cohen Y, Nel AE. PMID: 21323332; PMCID: PMC3896549.
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PubMed Mentions:
81 Fields:
Translation:
Animals
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No time to lose--high throughput screening to assess nanomaterial safety. Nanoscale. 2011 Apr; 3(4):1345-60.
Damoiseaux R, George S, Li M, Pokhrel S, Ji Z, France B, Xia T, Suarez E, Rallo R, Mädler L, Cohen Y, Hoek EM, Nel A. PMID: 21301704; PMCID: PMC3980675.
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PubMed Mentions:
42 Fields:
Translation:
Humans
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Self-organizing map analysis of toxicity-related cell signaling pathways for metal and metal oxide nanoparticles. Environ Sci Technol. 2011 Feb 15; 45(4):1695-702.
Rallo R, France B, Liu R, Nair S, George S, Damoiseaux R, Giralt F, Nel A, Bradley K, Cohen Y. PMID: 21250674; PMCID: PMC4418424.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Metabolic imaging allows early prediction of response to vandetanib. J Nucl Med. 2011 Feb; 52(2):231-40.
Walter MA, Benz MR, Hildebrandt IJ, Laing RE, Hartung V, Damoiseaux RD, Bockisch A, Phelps ME, Czernin J, Weber WA. PMID: 21233183.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Microfluidic image cytometry. Methods Mol Biol. 2011; 706:191-206.
Kamei K, Sun J, Tseng HR, Damoiseaux R. PMID: 21104065.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Stability, bioavailability, and bacterial toxicity of ZnO and iron-doped ZnO nanoparticles in aquatic media. Environ Sci Technol. 2011 Jan 15; 45(2):755-61.
Li M, Pokhrel S, Jin X, Mädler L, Damoiseaux R, Hoek EM. PMID: 21133426.
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PubMed Mentions:
33 Fields:
Translation:
Cells
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High-throughput screening of silver nanoparticle stability and bacterial inactivation in aquatic media: influence of specific ions. Environ Sci Technol. 2010 Oct 01; 44(19):7321-8.
Jin X, Li M, Wang J, Marambio-Jones C, Peng F, Huang X, Damoiseaux R, Hoek EM. PMID: 20873875.
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PubMed Mentions:
30 Fields:
Translation:
Cells
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High-content screening for biofilm assays. J Biomol Screen. 2010 Aug; 15(7):748-54.
Peng F, Hoek EM, Damoiseaux R. PMID: 20639506.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol. 2010 Jul; 28(7):738-42.
Aghajan M, Jonai N, Flick K, Fu F, Luo M, Cai X, Ouni I, Pierce N, Tang X, Lomenick B, Damoiseaux R, Hao R, Del Moral PM, Verma R, Li Y, Li C, Houk KN, Jung ME, Zheng N, Huang L, Deshaies RJ, Kaiser P, Huang J. PMID: 20581845; PMCID: PMC2902569.
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PubMed Mentions:
85 Fields:
Translation:
HumansCells
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Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9578-83.
Hasson SA, Damoiseaux R, Glavin JD, Dabir DV, Walker SS, Koehler CM. PMID: 20457929; PMCID: PMC2906835.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Integrated pathways for neutrophil recruitment and inflammation in leprosy. J Infect Dis. 2010 Feb 15; 201(4):558-69.
Lee DJ, Li H, Ochoa MT, Tanaka M, Carbone RJ, Damoiseaux R, Burdick A, Sarno EN, Rea TH, Modlin RL. PMID: 20070238; PMCID: PMC2811231.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3157-62.
Wolf MC, Freiberg AN, Zhang T, Akyol-Ataman Z, Grock A, Hong PW, Li J, Watson NF, Fang AQ, Aguilar HC, Porotto M, Honko AN, Damoiseaux R, Miller JP, Woodson SE, Chantasirivisal S, Fontanes V, Negrete OA, Krogstad P, Dasgupta A, Moscona A, Hensley LE, Whelan SP, Faull KF, Holbrook MR, Jung ME, Lee B. PMID: 20133606; PMCID: PMC2840368.
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PubMed Mentions:
134 Fields:
Translation:
Animals
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Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping. ACS Nano. 2010 Jan 26; 4(1):15-29.
George S, Pokhrel S, Xia T, Gilbert B, Ji Z, Schowalter M, Rosenauer A, Damoiseaux R, Bradley KA, Mädler L, Nel AE. PMID: 20043640; PMCID: PMC3900637.
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PubMed Mentions:
129 Fields:
Translation:
AnimalsCells
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High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones. Clin Cancer Res. 2009 Dec 01; 15(23):7238-45.
Kim K, Pollard JM, Norris AJ, McDonald JT, Sun Y, Micewicz E, Pettijohn K, Damoiseaux R, Iwamoto KS, Sayre JW, Price BD, Gatti RA, McBride WH. PMID: 19920105; PMCID: PMC2787903.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Nonaminoglycoside compounds induce readthrough of nonsense mutations. J Exp Med. 2009 Sep 28; 206(10):2285-97.
Du L, Damoiseaux R, Nahas S, Gao K, Hu H, Pollard JM, Goldstine J, Jung ME, Henning SM, Bertoni C, Gatti RA. PMID: 19770270; PMCID: PMC2757881.
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PubMed Mentions:
70 Fields:
Translation:
AnimalsCells
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Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. Am J Physiol Gastrointest Liver Physiol. 2010 Jan; 298(1):G63-73.
Ohno I, Eibl G, Odinokova I, Edderkaoui M, Damoiseaux RD, Yazbec M, Abrol R, Goddard WA, Yokosuka O, Pandol SJ, Gukovskaya AS. PMID: 19762431; PMCID: PMC2806098.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. Bioorg Med Chem. 2009 Oct 15; 17(20):7174-85.
Suree N, Yi SW, Thieu W, Marohn M, Damoiseaux R, Chan A, Jung ME, Clubb RT. PMID: 19781950; PMCID: PMC2888031.
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PubMed Mentions:
38 Fields:
Translation:
Cells
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Integrated chemical genomics reveals modifiers of survival in human embryonic stem cells. Stem Cells. 2009 Mar; 27(3):533-542.
Damoiseaux R, Sherman SP, Alva JA, Peterson C, Pyle AD. PMID: 19074420; PMCID: PMC3962308.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Ion channel and toxin measurement using a high throughput lipid membrane platform. Biosens Bioelectron. 2009 Feb 15; 24(6):1806-10.
Poulos JL, Jeon TJ, Damoiseaux R, Gillespie EJ, Bradley KA, Schmidt JJ. PMID: 18849158.
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PubMed Mentions:
12 Fields:
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Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways. J Acquir Immune Defic Syndr. 2008 Aug 15; 48(5):531-40.
Lee S, Deng H, Yu F, Melega WP, Damoiseaux R, Bradley KA, Sun R. PMID: 18645521.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11218-23.
Stoilov P, Lin CH, Damoiseaux R, Nikolic J, Black DL. PMID: 18678901; PMCID: PMC2516208.
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PubMed Mentions:
77 Fields:
Translation:
HumansCells
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Amiodarone and bepridil inhibit anthrax toxin entry into host cells. Antimicrob Agents Chemother. 2007 Jul; 51(7):2403-11.
Sanchez AM, Thomas D, Gillespie EJ, Damoiseaux R, Rogers J, Saxe JP, Huang J, Manchester M, Bradley KA. PMID: 17485504; PMCID: PMC1913235.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab. 2007 May; 5(5):357-70.
Waki H, Park KW, Mitro N, Pei L, Damoiseaux R, Wilpitz DC, Reue K, Saez E, Tontonoz P. PMID: 17488638.
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PubMed Mentions:
87 Fields:
Translation:
HumansAnimalsCells
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Mycophenolic acid is a potent inhibitor of angiogenesis. Arterioscler Thromb Vasc Biol. 2006 Oct; 26(10):2414-6.
Wu X, Zhong H, Song J, Damoiseaux R, Yang Z, Lin S. PMID: 16990565.
View in:
PubMed Mentions:
8 Fields:
Translation:
Animals
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Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death. Biochem Biophys Res Commun. 2006 Sep 29; 348(3):1101-6.
Kamata M, Wu RP, An DS, Saxe JP, Damoiseaux R, Phelps ME, Huang J, Chen IS. PMID: 16904642; PMCID: PMC1761125.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansCells