Caius Gabriel Radu

Title(s)Professor, Molecular and Medical Pharmacology
SchoolMedicine
ORCID ORCID Icon0000-0002-9338-5397 Additional info
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    Title(s)Professor, Surgery


    Collapse Biography 
    Collapse Education and Training
    National College, Craiova, RomâniaBS07/1987Mathematics and Physics
    University of Medicine, Craiova, RomâniaMD07/1993
    UT Southwestern Medical Center, Dallas, TX07/2001Postdoctoral training in Immunology
    University of California, Los Angeles07/2006Postdoctoral training in cancer biology
    Collapse Awards and Honors
    Prostate Cancer Foundation 2017  - 2019Challenge Award
    Prostate Cancer Foundation2019  - 2021Challenge Award

    Collapse Overview 
    Collapse Overview
    My group aims to advance the understanding of fundamental biological processes at the interface between metabolic and signal transduction networks in cancer, immune cells, and stromal cells and leverage this knowledge to develop new diagnostic and therapeutic approaches. We have established a highly integrated research program, including state-of-the-art instrumentation for both Positron Emission Tomography (PET) and Mass Spectrometry platforms (for metabolomics, proteomics, and phosphoproteomics), as well as an interdisciplinary team of investigators at UCLA and other institutions, with expertise in molecular imaging, cancer metabolism, immunobiology, signal transduction, structural biology, radiochemistry, medicinal chemistry, and virology. The potential of the program is demonstrated by recent work which uncovered a new role for the nucleoside salvage pathway in hematopoiesis, developed new PET probes for nucleotide metabolism, several of which have been successfully translated to the clinic, and discovered novel small molecule inhibitors of a metabolic kinase, from which a clinical candidate compound with low nanomolar affinity and oral bioavailability has emerged with indications in selected solid tumors and autoimmune disorders, and has entered Phase I clinical trials in Fall 2021 (NCT05055609). An additional area of research for my group concerns the immunobiology of pancreatic and prostate cancers. In this area, we seek to identify novel immunometabolic checkpoints that a) are governed by nucleosides and nucleotides, b) are interconnected with pattern recognition receptor and MAPK signaling pathways, and c) are amenable to pharmacological modulation alone or in combination with mutation-targeted therapies and immunotherapies. In collaboration with Dr. Norbert Pardi (UPenn), we have established a platform for developing and evaluating a novel mRNA lipid nanoparticle platform for cancer immunotherapy.

    Collapse Research 
    Collapse Research Activities and Funding
    Innovative mRNA vaccines to enhance the efficacy of T-cell transfer therapies against solid tumors
    NIH R01CA283736Aug 1, 2024 - Jul 31, 2029
    Role: Principal Investigator
    Causes and Consequences of Adenosine Signaling in Pancreatic Cancer
    NIH R01CA290888Jun 26, 2024 - May 31, 2029
    Role: MPI
    Multidimensional analyses to improve PSMA-RPT efficacy in mCRPC
    NIH R01CA279094Jul 12, 2023 - Mar 31, 2028
    Role: MPI
    Targeting KRAS and adenosine mediated immunosuppression in pancreatic cancer
    NIH R01CA260678Mar 1, 2021 - Feb 28, 2026
    Role: Principal Investigator
    Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
    NIH R01CA250529Feb 15, 2021 - Jan 31, 2026
    Role: MPI
    PET Imaging-guided Personalized Therapy in Pancreatic Cancer
    NIH R01CA187678Aug 18, 2014 - Jul 31, 2020
    Role: Principal Investigator
    Novel molecular imaging approaches to monitor gene and cell-based therapies
    NIH R01CA160770Sep 1, 2011 - Aug 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Staggered immunization with mRNA vaccines encoding SARS-CoV-2 polymerase or spike antigens broadens the T cell epitope repertoire. Proc Natl Acad Sci U S A. 2024 Dec 03; 121(49):e2406332121. Abt ER, Lam AK, Noguchi M, Rashid K, McLaughlin J, Teng PL, Tran W, Cheng D, Nesterenko PA, Mao Z, Creech AL, Burton Sojo G, Jeyachandran AV, Tam YK, Henley JE, Comai L, Pardi N, Arumugaswami V, Witte ON, Radu CG, Wu TT. PMID: 39589869.
      View in: PubMed   Mentions:
    2. Evaluating [225Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice. Eur J Nucl Med Mol Imaging. 2024 Nov; 51(13):4026-4037. Taddio MF, Doshi S, Masri M, Jeanjean P, Hikmat F, Gerlach A, Nyiranshuti L, Rosser EW, Schaue D, Besserer-Offroy E, Carlucci G, Radu CG, Czernin J, Lückerath K, Mona CE. PMID: 39008063; PMCID: PMC11527918.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Targeting host deoxycytidine kinase mitigates Staphylococcus aureus abscess formation. Elife. 2024 Mar 21; 12. Winstel V, Abt ER, Le TM, Radu CG. PMID: 38512723; PMCID: PMC10957174.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Targeting host deoxycytidine kinase mitigates Staphylococcus aureus abscess formation. bioRxiv. 2023 Dec 08. Winstel V, Abt ER, Le TM, Radu CG. PMID: 37645972; PMCID: PMC10462150.
      View in: PubMed   Mentions:
    5. Establishing a mouse model of lung metastases using ultrasound-guided right heart ventricle injection. STAR Protoc. 2023 Dec 15; 4(4):102698. Labora A, Creech A, Lee H, Tabornal E, Radu C, Donahue T. PMID: 37925631; PMCID: PMC10652205.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. MEK Inhibition Sensitizes Pancreatic Cancer to STING Agonism by Tumor Cell-intrinsic Amplification of Type I IFN Signaling. Clin Cancer Res. 2023 08 15; 29(16):3130-3141. Ghukasyan R, Liang K, Chau K, Li L, Chan C, Abt ER, Le T, Park JY, Wu N, Premji A, Damoiseaux R, Luu T, Labora A, Rashid K, Link JM, Radu CG, Donahue TR. PMID: 37195712; PMCID: PMC10865884.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Generation of liver metastases in a mouse model using ultrasound-guided intravenous injection. STAR Protoc. 2023 Mar 15; 4(2):102163. Labora A, Lee H, Chan C, Tabornal E, Le T, Rashid K, Abt E, Yamao T, Mandl H, Creech A, Premji A, Li L, Link J, Wu N, Radu C, Donahue T. PMID: 36930646; PMCID: PMC10036864.
      View in: PubMed   Mentions:    Fields:    
    8. Immunization of Mice with Virus-Like Vesicles of Kaposi Sarcoma-Associated Herpesvirus Reveals a Role for Antibodies Targeting ORF4 in Activating Complement-Mediated Neutralization. J Virol. 2023 02 28; 97(2):e0160022. Lam AK, Roshan R, Miley W, Labo N, Zhen J, Kurland AP, Cheng C, Huang H, Teng PL, Harelson C, Gong D, Tam YK, Radu CG, Epeldegui M, Johnson JR, Zhou ZH, Whitby D, Wu TT. PMID: 36757205; PMCID: PMC9972917.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    9. Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer. Cancer Discov. 2023 02 06; 13(2):298-311. Kemp SB, Cheng N, Markosyan N, Sor R, Kim IK, Hallin J, Shoush J, Quinones L, Brown NV, Bassett JB, Joshi N, Yuan S, Smith M, Vostrejs WP, Perez-Vale KZ, Kahn B, Mo F, Donahue TR, Radu CG, Clendenin C, Christensen JG, Vonderheide RH, Stanger BZ. PMID: 36472553; PMCID: PMC9900321.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    10. Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency. Drug Resist Updat. 2023 03; 67:100932. Guantay L, Garro C, Siri S, Pansa MF, Ghidelli-Disse S, Paviolo N, Racca A, Nicotra V, Radu C, Bocco JL, Felice R, Jansson KH, Remlinger K, Amador A, Stronach E, Coleman K, Muelbaier M, Drewes G, Gloger I, Madauss K, García M, Gottifredi V, Soria G. PMID: 36706533.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis. Immunology. 2023 01; 168(1):152-169. Chen BY, Salas JR, Trias AO, Perez Rodriguez A, Tsang JE, Guemes M, Le TM, Galic Z, Shepard HM, Steinman L, Nathanson DA, Czernin J, Witte ON, Radu CG, Schultz KA, Clark PM. PMID: 35986643; PMCID: PMC9844239.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity. J Clin Invest. 2022 08 15; 132(16). Abt ER, Rashid K, Le TM, Li S, Lee HR, Lok V, Li L, Creech AL, Labora AN, Mandl HK, Lam AK, Cho A, Rezek V, Wu N, Abril-Rodriguez G, Rosser EW, Mittelman SD, Hugo W, Mehrling T, Bantia S, Ribas A, Donahue TR, Crooks GM, Wu TT, Radu CG. PMID: 35653193; PMCID: PMC9374381.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    13. 18F-FDG PET Visualizes Systemic STING Agonist-Induced Lymphocyte Activation in Preclinical Models. J Nucl Med. 2023 01; 64(1):117-123. Le TM, Lee HR, Abt ER, Rashid K, Creech AL, Liang K, Cui J, Cho A, Wei L, Labora A, Chan C, Sanchez E, Kriti K, Karin D, Li L, Wu N, Mona C, Carlucci G, Hugo W, Wu TT, Donahue TR, Czernin J, Radu CG. PMID: 35738905; PMCID: PMC9841248.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    14. Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand-Addicted Pancreatic Cancer. Mol Cancer Ther. 2022 06 01; 21(6):936-947. Aguilera KY, Le T, Riahi R, Lay AR, Hinz S, Saadat EA, Vashisht AA, Wohlschlegel J, Donahue TR, Radu CG, Dawson DW. PMID: 35313331; PMCID: PMC9167706.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair. J Clin Invest. 2022 01 18; 132(2). Li S, Yokota T, Wang P, Ten Hoeve J, Ma F, Le TM, Abt ER, Zhou Y, Wu R, Nanthavongdouangsy M, Rodriguez A, Wang Y, Lin YJ, Muranaka H, Sharpley M, Braddock DT, MacRae VE, Banerjee U, Chiou PY, Seldin M, Huang D, Teitell M, Gertsman I, Jung M, Bensinger SJ, Damoiseaux R, Faull K, Pellegrini M, Lusis AJ, Graeber TG, Radu CG, Deb A. PMID: 34813507; PMCID: PMC8759793.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    16. Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells. Cell Rep. 2022 01 11; 38(2):110236. Abt ER, Le TM, Dann AM, Capri JR, Poddar S, Lok V, Li L, Liang K, Creech AL, Rashid K, Kim W, Wu N, Cui J, Cho A, Lee HR, Rosser EW, Link JM, Czernin J, Wu TT, Damoiseaux R, Dawson DW, Donahue TR, Radu CG. PMID: 35021095; PMCID: PMC8893345.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [18F]FLT PET imaging. Proc Natl Acad Sci U S A. 2021 09 07; 118(36). Liang K, Abt ER, Le TM, Cho A, Dann AM, Cui J, Li L, Rashid K, Creech AL, Wei L, Ghukasyan R, Rosser EW, Wu N, Carlucci G, Czernin J, Donahue TR, Radu CG. PMID: 34480004; PMCID: PMC8433573.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. Leadership Focus on Advancing Cancer Research and Treatment: A Conversation Between Johannes Czernin, Caius Radu, and Antoni Ribas. J Nucl Med. 2021 Sep 01; 62(9):1178-1180. Czernin J, Radu C, Ribas A. PMID: 34475241.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition. Proc Natl Acad Sci U S A. 2021 02 23; 118(8). Moore AM, Zhou L, Cui J, Li L, Wu N, Yu A, Poddar S, Liang K, Abt ER, Kim S, Ghukasyan R, Khachatourian N, Pagano K, Elliott I, Dann AM, Riahi R, Le T, Dawson DW, Radu CG, Donahue TR. PMID: 33597293; PMCID: PMC7923374.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    20. The Solutions Come from Science and Knowledge. J Nucl Med. 2021 02; 62(2):145. Czernin J, Radu C. PMID: 33310739.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    21. Mechanisms of Resistance to Prostate-Specific Membrane Antigen-Targeted Radioligand Therapy in a Mouse Model of Prostate Cancer. J Nucl Med. 2021 Jul 01; 62(7):989-995. Stuparu AD, Capri JR, Meyer CAL, Le TM, Evans-Axelsson SL, Current K, Lennox M, Mona CE, Fendler WP, Calais J, Eiber M, Dahlbom M, Czernin J, Radu CG, Lückerath K, Slavik R. PMID: 33277393; PMCID: PMC8882874.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    22. Immune-Checkpoint Blockade Enhances 225Ac-PSMA617 Efficacy in a Mouse Model of Prostate Cancer. J Nucl Med. 2021 02; 62(2):228-231. Czernin J, Current K, Mona CE, Nyiranshuti L, Hikmat F, Radu CG, Lückerath K. PMID: 32646877.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    23. Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy. Proc Natl Acad Sci U S A. 2020 06 30; 117(26):15172-15181. Bicak M, Lückerath K, Kalidindi T, Phelps ME, Strand SE, Morris MJ, Radu CG, Damoiseaux R, Peltola MT, Peekhaus N, Ho A, Veach D, Malmborg Hager AC, Larson SM, Lilja H, McDevitt MR, Klein RJ, Ulmert D. PMID: 32532924; PMCID: PMC7334567.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    24. Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias. RSC Med Chem. 2020 Mar 01; 11(3):392-410. Sun DL, Poddar S, Pan RD, Rosser EW, Abt ER, Van Valkenburgh J, Le TM, Lok V, Hernandez SP, Song J, Li J, Turlik A, Chen X, Cheng CA, Chen W, Mona CE, Stuparu AD, Vergnes L, Reue K, Damoiseaux R, Zink JI, Czernin J, Donahue TR, Houk KN, Jung ME, Radu CG. PMID: 33479645; PMCID: PMC7593890.
      View in: PubMed   Mentions: 3  
    25. Targeted alpha therapy in a systemic mouse model of prostate cancer - a feasibility study. Theranostics. 2020; 10(6):2612-2620. Stuparu AD, Meyer CAL, Evans-Axelsson SL, Lückerath K, Wei LH, Kim W, Poddar S, Mona CE, Dahlbom M, Girgis MD, Radu CG, Czernin J, Slavik R. PMID: 32194823; PMCID: PMC7052903.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    26. Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity. Clin Cancer Res. 2020 06 15; 26(12):2946-2955. Current K, Meyer C, Magyar CE, Mona CE, Almajano J, Slavik R, Stuparu AD, Cheng C, Dawson DW, Radu CG, Czernin J, Lueckerath K. PMID: 31932492; PMCID: PMC7299755.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    27. Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression. Theranostics. 2020; 10(2):829-840. Kim SS, Xu S, Cui J, Poddar S, Le TM, Hayrapetyan H, Li L, Wu N, Moore AM, Zhou L, Yu AC, Dann AM, Elliott IA, Abt ER, Kim W, Dawson DW, Radu CG, Donahue TR. PMID: 31903153; PMCID: PMC6929997.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. Development and preclinical pharmacology of a novel dCK inhibitor, DI-87. Biochem Pharmacol. 2020 02; 172:113742. Poddar S, Capparelli EV, Rosser EW, Gipson RM, Wei L, Le T, Jung ME, Radu C, Nikanjam M. PMID: 31812677; PMCID: PMC6981055.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    29. Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism. Cell Chem Biol. 2020 02 20; 27(2):197-205.e6. Abt ER, Rosser EW, Durst MA, Lok V, Poddar S, Le TM, Cho A, Kim W, Wei L, Song J, Capri JR, Xu S, Wu N, Slavik R, Jung ME, Damoiseaux R, Czernin J, Donahue TR, Lavie A, Radu CG. PMID: 31734178; PMCID: PMC7035983.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    30. 18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis. J Nucl Med. 2020 05; 61(5):757-763. Chen BY, Ghezzi C, Villegas B, Quon A, Radu CG, Witte ON, Clark PM. PMID: 31653711; PMCID: PMC7198381.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. 2019 10 03; 25(4):542-557.e9. Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, McLaughlin J, Cheng D, Hollis RP, Campo-Fernandez B, Urbinati F, Wei L, Pang L, Rezek V, Berent-Maoz B, Macabali MH, Gjertson D, Wang X, Galic Z, Kitchen SG, An DS, Hu-Lieskovan S, Kaplan-Lefko PJ, De Oliveira SN, Seet CS, Larson SM, Forman SJ, Heath JR, Zack JA, Crooks GM, Radu CG, Ribas A, Kohn DB, Witte ON, Yang L. PMID: 31495780; PMCID: PMC7018522.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    32. Activity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs. J Biol Inorg Chem. 2019 08; 24(5):621-632. Plamthottam S, Sun D, Van Valkenburgh J, Valenzuela J, Ruehle B, Steele D, Poddar S, Marshalik M, Hernandez S, Radu CG, Zink JI. PMID: 31250199; PMCID: PMC7849610.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    33. Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):6842-6847. Elliott IA, Dann AM, Xu S, Kim SS, Abt ER, Kim W, Poddar S, Moore A, Zhou L, Williams JL, Capri JR, Ghukasyan R, Matsumura C, Tucker DA, Armstrong WR, Cabebe AE, Wu N, Li L, Le TM, Radu CG, Donahue TR. PMID: 30894490; PMCID: PMC6452719.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    34. Preclinical evaluation of PSMA expression in response to androgen receptor blockade for theranostics in prostate cancer. EJNMMI Res. 2018 Oct 29; 8(1):96. Lückerath K, Wei L, Fendler WP, Evans-Axelsson S, Stuparu AD, Slavik R, Mona CE, Calais J, Rettig M, Reiter RE, Herrmann K, Radu CG, Czernin J, Eiber M. PMID: 30374743; PMCID: PMC6206308.
      View in: PubMed   Mentions: 41  
    35. Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities. Cancer Metab. 2018; 6:4. Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. PMID: 29692895; PMCID: PMC5905129.
      View in: PubMed   Mentions: 35  
    36. Detection Threshold and Reproducibility of 68Ga-PSMA11 PET/CT in a Mouse Model of Prostate Cancer. J Nucl Med. 2018 09; 59(9):1392-1397. Lückerath K, Stuparu AD, Wei L, Kim W, Radu CG, Mona CE, Calais J, Rettig M, Reiter RE, Czernin J, Slavik R, Herrmann K, Eiber M, Fendler WP. PMID: 29602819; PMCID: PMC6910618.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    37. Detection of immune responses after immunotherapy in glioblastoma using PET and MRI. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):10220-10225. Antonios JP, Soto H, Everson RG, Moughon DL, Wang AC, Orpilla J, Radu C, Ellingson BM, Lee JT, Cloughesy T, Phelps ME, Czernin J, Liau LM, Prins RM. PMID: 28874539; PMCID: PMC5617282.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    38. ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. Nat Commun. 2017 08 14; 8(1):241. Le TM, Poddar S, Capri JR, Abt ER, Kim W, Wei L, Uong NT, Cheng CM, Braas D, Nikanjam M, Rix P, Merkurjev D, Zaretsky J, Kornblum HI, Ribas A, Herschman HR, Whitelegge J, Faull KF, Donahue TR, Czernin J, Radu CG. PMID: 28808226; PMCID: PMC5556071.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    39. Establishing 177Lu-PSMA-617 Radioligand Therapy in a Syngeneic Model of Murine Prostate Cancer. J Nucl Med. 2017 11; 58(11):1786-1792. Fendler WP, Stuparu AD, Evans-Axelsson S, Lückerath K, Wei L, Kim W, Poddar S, Said J, Radu CG, Eiber M, Czernin J, Slavik R, Herrmann K. PMID: 28546332; PMCID: PMC6944167.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    40. Histone deacetylase inhibitors provoke a tumor supportive phenotype in pancreatic cancer associated fibroblasts. Oncotarget. 2017 Mar 21; 8(12):19074-19088. Nguyen AH, Elliott IA, Wu N, Matsumura C, Vogelauer M, Attar N, Dann A, Ghukasyan R, Toste PA, Patel SG, Williams JL, Li L, Dawson DW, Radu C, Kurdistani SK, Donahue TR. PMID: 27894105; PMCID: PMC5386671.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    41. Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets. Cell Chem Biol. 2016 Dec 22; 23(12):1490-1503. Knezevic CE, Wright G, Rix LLR, Kim W, Kuenzi BM, Luo Y, Watters JM, Koomen JM, Haura EB, Monteiro AN, Radu C, Lawrence HR, Rix U. PMID: 27866910; PMCID: PMC5182133.
      View in: PubMed   Mentions: 55     Fields:    
    42. Human Biodistribution and Radiation Dosimetry of 18F-Clofarabine, a PET Probe Targeting the Deoxyribonucleoside Salvage Pathway. J Nucl Med. 2017 03; 58(3):374-378. Barrio MJ, Spick C, Radu CG, Lassmann M, Eberlein U, Allen-Auerbach M, Schiepers C, Slavik R, Czernin J, Herrmann K. PMID: 27811125; PMCID: PMC6945110.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    43. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628; PMCID: PMC4934679.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    44. Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma. Mol Cancer Ther. 2016 06; 15(6):1271-8. Laks DR, Ta L, Crisman TJ, Gao F, Coppola G, Radu CG, Nathanson DA, Kornblum HI. PMID: 27196770; PMCID: PMC4893966.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    45. [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4027-32. Kim W, Le TM, Wei L, Poddar S, Bazzy J, Wang X, Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D, Gipson RM, Slavik R, Cabebe AE, Taechariyakul T, Yaghoubi SS, Lee JT, Sadeghi S, Lavie A, Faull KF, Witte ON, Donahue TR, Phelps ME, Herschman HR, Herrmann K, Czernin J, Radu CG. PMID: 27035974; PMCID: PMC4839461.
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    46. A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2'-dC upon inhibition of ribonucleotide reductase. Epigenetics Chromatin. 2015; 8:42. Minkovsky A, Sahakyan A, Bonora G, Damoiseaux R, Dimitrova E, Rubbi L, Pellegrini M, Radu CG, Plath K. PMID: 26468331; PMCID: PMC4604769.
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    47. Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities. Nat Commun. 2015 Jun 12; 6:7389. Kollareddy M, Dimitrova E, Vallabhaneni KC, Chan A, Le T, Chauhan KM, Carrero ZI, Ramakrishnan G, Watabe K, Haupt Y, Haupt S, Pochampally R, Boss GR, Romero DG, Radu CG, Martinez LA. PMID: 26067754; PMCID: PMC4467467.
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    48. Targeted noninvasive imaging of the innate immune response. Proc Natl Acad Sci U S A. 2015 May 12; 112(19):5868-9. McCracken MN, Radu CG. PMID: 25934920; PMCID: PMC4434762.
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    49. Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. J Med Chem. 2014 Nov 26; 57(22):9480-94. Nomme J, Li Z, Gipson RM, Wang J, Armijo AL, Le T, Poddar S, Smith T, Santarsiero BD, Nguyen HA, Czernin J, Alexandrova AN, Jung ME, Radu CG, Lavie A. PMID: 25341194; PMCID: PMC4255734.
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    50. Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. PLoS One. 2014; 9(8):e104125. Bunimovich YL, Nair-Gill E, Riedinger M, McCracken MN, Cheng D, McLaughlin J, Radu CG, Witte ON. PMID: 25101980; PMCID: PMC4125169.
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    51. INDs for PET molecular imaging probes-approach by an academic institution. Mol Imaging Biol. 2014 Aug; 16(4):441-8. Mosessian S, Duarte-Vogel SM, Stout DB, Roos KP, Lawson GW, Jordan MC, Ogden A, Matter C, Sadeghi S, Mills GQ, Schelbert HR, Radu CG, Czernin J, Couto M, Phelps ME. PMID: 24733693; PMCID: PMC4097325.
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    52. The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia. Dis Model Mech. 2014 Jul; 7(7):895-905. Danilova N, Bibikova E, Covey TM, Nathanson D, Dimitrova E, Konto Y, Lindgren A, Glader B, Radu CG, Sakamoto KM, Lin S. PMID: 24812435; PMCID: PMC4073278.
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    53. Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clin Cancer Res. 2014 May 01; 20(9):2457-65. Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, Gjertson DW, Cochran AJ, Cornetta K, Wong DJ, Kaplan-Lefko P, Hamid O, Samlowski W, Cohen PA, Daniels GA, Mukherji B, Yang L, Zack JA, Kohn DB, Heath JR, Glaspy JA, Witte ON, Baltimore D, Economou JS, Ribas A. PMID: 24634374; PMCID: PMC4070853.
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    54. Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J Exp Med. 2014 Mar 10; 211(3):473-86. Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. PMID: 24567448; PMCID: PMC3949575.
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    55. Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules. Acta Crystallogr D Biol Crystallogr. 2014 Jan; 70(Pt 1):68-78. Nomme J, Murphy JM, Su Y, Sansone ND, Armijo AL, Olson ST, Radu C, Lavie A. PMID: 24419380; PMCID: PMC3919262.
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    56. PET imaging to non-invasively study immune activation leading to antitumor responses with a 4-1BB agonistic antibody. J Immunother Cancer. 2013; 1:14. Escuin-Ordinas H, Elliott MW, Atefi M, Lee M, Ng C, Wei L, Comin-Anduix B, Montecino-Rodriguez E, Avramis E, Radu C, Sharp LL, Ribas A. PMID: 24829750; PMCID: PMC4019904.
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    57. Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system. J Nucl Med. 2013 Oct; 54(10):1820-4. Wang J, Hwang K, Braas D, Dooraghi A, Nathanson D, Campbell DO, Gu Y, Sandberg T, Mischel P, Radu C, Chatziioannou AF, Phelps ME, Christofk H, Heath JR. PMID: 23978446; PMCID: PMC4106462.
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    58. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem. 2013 Sep 12; 56(17):6696-708. Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. PMID: 23947754; PMCID: PMC3789385.
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    59. Application of a rapid, simple, and accurate adenovirus-based method to compare PET reporter gene/PET reporter probe systems. Mol Imaging Biol. 2013 Jun; 15(3):273-81. Gil JS, Machado HB, Campbell DO, McCracken M, Radu C, Witte ON, Herschman HR. PMID: 23054556; PMCID: PMC3833443.
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    60. Evaluation of the Genisys4, a bench-top preclinical PET scanner. J Nucl Med. 2013 Jul; 54(7):1162-7. Herrmann K, Dahlbom M, Nathanson D, Wei L, Radu C, Chatziioannou A, Czernin J. PMID: 23628700; PMCID: PMC3790646.
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    61. High-pressure, compact, modular radiosynthesizer for production of positron emitting biomarkers. Appl Radiat Isot. 2013 Aug; 78:88-101. Amaraesekera B, Marchis PD, Bobinski KP, Radu CG, Czernin J, Barrio JR, Michael van Dam R. PMID: 23702794.
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    62. Using the BLT humanized mouse as a stem cell based gene therapy tumor model. J Vis Exp. 2012 Dec 18; (70):e4181. Vatakis DN, Bristol GC, Kim SG, Levin B, Liu W, Radu CG, Kitchen SG, Zack JA. PMID: 23271478; PMCID: PMC3576416.
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    63. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med. 2012 Nov 19; 209(12):2215-28. Austin WR, Armijo AL, Campbell DO, Singh AS, Hsieh T, Nathanson D, Herschman HR, Phelps ME, Witte ON, Czernin J, Radu CG. PMID: 23148236; PMCID: PMC3501349.
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    64. In vivo imaging of therapy-induced anti-cancer immune responses in humans. Cell Mol Life Sci. 2013 Jul; 70(13):2237-57. Aarntzen EH, Srinivas M, Radu CG, Punt CJ, Boerman OC, Figdor CG, Oyen WJ, de Vries IJ. PMID: 23052208; PMCID: PMC3676735.
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    65. Positron emission tomography reporter genes and reporter probes: gene and cell therapy applications. Theranostics. 2012; 2(4):374-91. Yaghoubi SS, Campbell DO, Radu CG, Czernin J. PMID: 22509201; PMCID: PMC3326723.
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    66. Stratification of nucleoside analog chemotherapy using 1-(2'-deoxy-2'-18F-fluoro-β-D-arabinofuranosyl)cytosine and 1-(2'-deoxy-2'-18F-fluoro-β-L-arabinofuranosyl)-5-methylcytosine PET. J Nucl Med. 2012 Feb; 53(2):275-80. Lee JT, Campbell DO, Satyamurthy N, Czernin J, Radu CG. PMID: 22302964; PMCID: PMC3431619.
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    67. Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):E1408-16. Vatakis DN, Koya RC, Nixon CC, Wei L, Kim SG, Avancena P, Bristol G, Baltimore D, Kohn DB, Ribas A, Radu CG, Galic Z, Zack JA. PMID: 22123951; PMCID: PMC3251070.
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    68. Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe. J Biol Chem. 2012 Jan 02; 287(1):446-454. Campbell DO, Yaghoubi SS, Su Y, Lee JT, Auerbach MS, Herschman H, Satyamurthy N, Czernin J, Lavie A, Radu CG. PMID: 22074768; PMCID: PMC3249097.
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    69. 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: a pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response. Cancer. 2012 Jun 15; 118(12):3135-44. Benz MR, Czernin J, Allen-Auerbach MS, Dry SM, Sutthiruangwong P, Spick C, Radu C, Weber WA, Tap WD, Eilber FC. PMID: 22020872; PMCID: PMC3436595.
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    70. A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells. Nat Med. 2011 Jun; 17(6):738-43. Ma C, Fan R, Ahmad H, Shi Q, Comin-Anduix B, Chodon T, Koya RC, Liu CC, Kwong GA, Radu CG, Ribas A, Heath JR. PMID: 21602800; PMCID: PMC3681612.
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    71. Clustered Arg-Gly-Asp peptides enhances tumor targeting of nonviral vectors. ChemMedChem. 2011 Apr 04; 6(4):623-7. Ng QK, Su H, Armijo AL, Czernin J, Radu CG, Segura T. PMID: 21442757; PMCID: PMC3079200.
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    72. Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway. Eur J Nucl Med Mol Imaging. 2011 Apr; 38(4):711-21. Schwarzenberg J, Radu CG, Benz M, Fueger B, Tran AQ, Phelps ME, Witte ON, Satyamurthy N, Czernin J, Schiepers C. PMID: 21127859; PMCID: PMC3053458.
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    73. Study of an image-derived SUV and a modified SUV using mouse FDG-PET. Nucl Med Biol. 2011 Apr; 38(3):353-62. Zheng X, Yu CL, Sha W, Radu C, Huang SC, Feng D. PMID: 21492784; PMCID: PMC3078337.
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    74. Imaging adoptive cell transfer based cancer immunotherapy. Curr Pharm Biotechnol. 2010 Sep 01; 11(6):672-84. Rabinovich BA, Radu CG. PMID: 20497110.
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    75. Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14286-91. Koya RC, Mok S, Comin-Anduix B, Chodon T, Radu CG, Nishimura MI, Witte ON, Ribas A. PMID: 20624956; PMCID: PMC2922609.
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    76. Novel PET probes specific for deoxycytidine kinase. J Nucl Med. 2010 Jul; 51(7):1092-8. Shu CJ, Campbell DO, Lee JT, Tran AQ, Wengrod JC, Witte ON, Phelps ME, Satyamurthy N, Czernin J, Radu CG. PMID: 20554721; PMCID: PMC3119947.
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    77. PET probes for distinct metabolic pathways have different cell specificities during immune responses in mice. J Clin Invest. 2010 Jun; 120(6):2005-15. Nair-Gill E, Wiltzius SM, Wei XX, Cheng D, Riedinger M, Radu CG, Witte ON. PMID: 20484820; PMCID: PMC2877561.
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    78. Targeting leukemia stem cells. Nat Biotechnol. 2010 Mar; 28(3):237-8. Mikkola HK, Radu CG, Witte ON. PMID: 20212485.
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    79. Imaging of CTLA4 blockade-induced cell replication with (18)F-FLT PET in patients with advanced melanoma treated with tremelimumab. J Nucl Med. 2010 Mar; 51(3):340-6. Ribas A, Benz MR, Allen-Auerbach MS, Radu C, Chmielowski B, Seja E, Williams JL, Gomez-Navarro J, McCarthy T, Czernin J. PMID: 20150263.
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    80. Visualizing cancer and immune cell function with metabolic positron emission tomography. Curr Opin Genet Dev. 2010 Feb; 20(1):100-5. Laing RE, Nair-Gill E, Witte ON, Radu CG. PMID: 19931447; PMCID: PMC3799818.
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    81. Epithelial uptake of [18F]1-(2'-deoxy-2'-arabinofuranosyl) cytosine indicates intestinal inflammation in mice. Gastroenterology. 2010 Apr; 138(4):1266-75. Brewer S, Nair-Gill E, Wei B, Chen L, Li X, Riedinger M, Campbell DO, Wiltzius S, Satyamurthy N, Phelps ME, Radu C, Witte ON, Braun J. PMID: 20080095; PMCID: PMC2846967.
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    82. AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas. Cell Cycle. 2010 Jan 15; 9(2):211-2. Guo D, Cloughesy TF, Radu CG, Mischel PS. PMID: 20023392; PMCID: PMC3180897.
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    83. Requirement for deoxycytidine kinase in T and B lymphocyte development. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5551-6. Toy G, Austin WR, Liao HI, Cheng D, Singh A, Campbell DO, Ishikawa TO, Lehmann LW, Satyamurthy N, Phelps ME, Herschman HR, Czernin J, Witte ON, Radu CG. PMID: 20080663; PMCID: PMC2851816.
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    84. Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood. 2009 Sep 24; 114(13):2774-82. Kottyan LC, Collier AR, Cao KH, Niese KA, Hedgebeth M, Radu CG, Witte ON, Khurana Hershey GK, Rothenberg ME, Zimmermann N. PMID: 19641187; PMCID: PMC2756132.
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    85. Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells. J Am Chem Soc. 2009 Jul 22; 131(28):9695-703. Kwong GA, Radu CG, Hwang K, Shu CJ, Ma C, Koya RC, Comin-Anduix B, Hadrup SR, Bailey RC, Witte ON, Schumacher TN, Ribas A, Heath JR. PMID: 19552409; PMCID: PMC2720314.
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    86. The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12932-7. Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, Czernin J, Shyy JY, Watson AD, Phelps M, Radu CG, Cloughesy TF, Mischel PS. PMID: 19625624; PMCID: PMC2714280.
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    87. Integrated microfluidic devices for combinatorial cell-based assays. Biomed Microdevices. 2009 Jun; 11(3):547-55. Yu ZT, Kamei K, Takahashi H, Shu CJ, Wang X, He GW, Silverman R, Radu CG, Witte ON, Lee KB, Tseng HR. PMID: 19130244; PMCID: PMC2893875.
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    88. Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2847-52. Laing RE, Walter MA, Campbell DO, Herschman HR, Satyamurthy N, Phelps ME, Czernin J, Witte ON, Radu CG. PMID: 19196993; PMCID: PMC2636738.
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    89. A supramolecular approach for preparation of size-controlled nanoparticles. Angew Chem Int Ed Engl. 2009; 48(24):4344-8. Wang H, Wang S, Su H, Chen KJ, Armijo AL, Lin WY, Wang Y, Sun J, Kamei K, Czernin J, Radu CG, Tseng HR. PMID: 19425037; PMCID: PMC2995451.
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    90. Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen. Int Immunol. 2009 Feb; 21(2):155-65. Shu CJ, Radu CG, Shelly SM, Vo DD, Prins R, Ribas A, Phelps ME, Witte ON. PMID: 19106231; PMCID: PMC2638874.
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    91. Engineered antibody fragments with infinite affinity as reporter genes for PET imaging. J Nucl Med. 2008 Nov; 49(11):1828-35. Wei LH, Olafsen T, Radu C, Hildebrandt IJ, McCoy MR, Phelps ME, Meares C, Wu AM, Czernin J, Weber WA. PMID: 18927335.
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    92. Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog. Nat Med. 2008 Jul; 14(7):783-8. Radu CG, Shu CJ, Nair-Gill E, Shelly SM, Barrio JR, Satyamurthy N, Phelps ME, Witte ON. PMID: 18542051; PMCID: PMC2720060.
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    93. PET imaging of cancer immunotherapy. J Nucl Med. 2008 Jun; 49(6):865-8. Tumeh PC, Radu CG, Ribas A. PMID: 18511842.
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    94. Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain. Cancer Immunol Immunother. 2008 Sep; 57(9):1279-89. Prins RM, Shu CJ, Radu CG, Vo DD, Khan-Farooqi H, Soto H, Yang MY, Lin MS, Shelly S, Witte ON, Ribas A, Liau LM. PMID: 18253732; PMCID: PMC2614264.
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    95. Non-invasive imaging of adaptive immunity using positron emission tomography. Immunol Rev. 2008 Feb; 221:214-28. Nair-Gill ED, Shu CJ, Radu CG, Witte ON. PMID: 18275485.
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    96. Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. J Biol Chem. 2008 Feb 29; 283(9):5296-305. Peter C, Waibel M, Radu CG, Yang LV, Witte ON, Schulze-Osthoff K, Wesselborg S, Lauber K. PMID: 18089568.
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    97. Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20501-6. McLaughlin J, Cheng D, Singer O, Lukacs RU, Radu CG, Verma IM, Witte ON. PMID: 18079287; PMCID: PMC2154460.
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    98. Requirements for T lymphocyte migration in explanted lymph nodes. J Immunol. 2007 Jun 15; 178(12):7747-55. Huang JH, Cárdenas-Navia LI, Caldwell CC, Plumb TJ, Radu CG, Rocha PN, Wilder T, Bromberg JS, Cronstein BN, Sitkovsky M, Dewhirst MW, Dustin ML. PMID: 17548612.
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    99. DNA-encoded antibody libraries: a unified platform for multiplexed cell sorting and detection of genes and proteins. J Am Chem Soc. 2007 Feb 21; 129(7):1959-67. Bailey RC, Kwong GA, Radu CG, Witte ON, Heath JR. PMID: 17260987; PMCID: PMC3677962.
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    100. Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1937-42. Radu CG, Shu CJ, Shelly SM, Phelps ME, Witte ON. PMID: 17261805; PMCID: PMC1783904.
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    101. Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Mol Cell Biol. 2007 Feb; 27(4):1334-47. Yang LV, Radu CG, Roy M, Lee S, McLaughlin J, Teitell MA, Iruela-Arispe ML, Witte ON. PMID: 17145776; PMCID: PMC1800706.
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    102. Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor. Mol Cell Biol. 2006 Jan; 26(2):668-77. Radu CG, Cheng D, Nijagal A, Riedinger M, McLaughlin J, Yang LV, Johnson J, Witte ON. PMID: 16382156; PMCID: PMC1346912.
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    103. Visualization of a primary anti-tumor immune response by positron emission tomography. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17412-7. Shu CJ, Guo S, Kim YJ, Shelly SM, Nijagal A, Ray P, Gambhir SS, Radu CG, Witte ON. PMID: 16293690; PMCID: PMC1283986.
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    104. Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A. Mol Biol Cell. 2005 May; 16(5):2234-47. Wang L, Radu CG, Yang LV, Bentolila LA, Riedinger M, Witte ON. PMID: 15728718; PMCID: PMC1087231.
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    105. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1632-7. Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON. PMID: 15665078; PMCID: PMC545089.
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    106. Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. Blood. 2005 Feb 01; 105(3):1127-34. Yang LV, Radu CG, Wang L, Riedinger M, Witte ON. PMID: 15383458.
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    107. T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):245-50. Radu CG, Yang LV, Riedinger M, Au M, Witte ON. PMID: 14681556; PMCID: PMC314170.
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    108. IL-1 receptor-associated kinase 1 regulates susceptibility to organ-specific autoimmunity. J Immunol. 2003 Mar 15; 170(6):2833-42. Deng C, Radu C, Diab A, Tsen MF, Hussain R, Cowdery JS, Racke MK, Thomas JA. PMID: 12626533.
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    109. Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au. Immunity. 2002 Jul; 17(1):83-94. He XL, Radu C, Sidney J, Sette A, Ward ES, Garcia KC. PMID: 12150894.
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