Hanna K A Mikkola

Title(s)Professor, Molecular, Cell and Developmental Biology
SchoolCollege of Letters and Science
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells. Nat Biotechnol. 2024 Sep 02. Ng ES, Sarila G, Li JY, Edirisinghe HS, Saxena R, Sun S, Bruveris FF, Labonne T, Sleebs N, Maytum A, Yow RY, Inguanti C, Motazedian A, Calvanese V, Capellera-Garcia S, Ma F, Nim HT, Ramialison M, Bonifer C, Mikkola HKA, Stanley EG, Elefanty AG. PMID: 39223325.
      View in: PubMed   Mentions: 4     Fields:    
    2. MYCT1 controls environmental sensing in human haematopoietic stem cells. Nature. 2024 Jun; 630(8016):412-420. Aguadé-Gorgorió J, Jami-Alahmadi Y, Calvanese V, Kardouh M, Fares I, Johnson H, Rezek V, Ma F, Magnusson M, Wang Y, Shin JE, Nance KJ, Goodridge HS, Liebscher S, Schenke-Layland K, Crooks GM, Wohlschlegel JA, Mikkola HKA. PMID: 38839950; PMCID: PMC11168926.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    3. The genesis of human hematopoietic stem cells. Blood. 2023 08 10; 142(6):519-532. Calvanese V, Mikkola HKA. PMID: 37339578; PMCID: PMC10447622.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    4. Mapping human haematopoietic stem cells from haemogenic endothelium to birth. Nature. 2022 04; 604(7906):534-540. Calvanese V, Capellera-Garcia S, Ma F, Fares I, Liebscher S, Ng ES, Ekstrand S, Aguadé-Gorgorió J, Vavilina A, Lefaudeux D, Nadel B, Li JY, Wang Y, Lee LK, Ardehali R, Iruela-Arispe ML, Pellegrini M, Stanley EG, Elefanty AG, Schenke-Layland K, Mikkola HKA. PMID: 35418685; PMCID: PMC9645817.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    5. Yolk sac steps up to the plate. J Exp Med. 2022 03 07; 219(3). Mikkola HKA. PMID: 35201267; PMCID: PMC8932537.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration. Adv Sci (Weinh). 2021 Feb; 8(4):2002500. Zbinden A, Layland SL, Urbanczyk M, Carvajal Berrio DA, Marzi J, Zauner M, Hammerschmidt A, Brauchle EM, Sudrow K, Fink S, Templin M, Liebscher S, Klein G, Deb A, Duffy GP, Crooks GM, Eble JA, Mikkola HKA, Nsair A, Seifert M, Schenke-Layland K. PMID: 33643791; PMCID: PMC7887579.
      View in: PubMed   Mentions: 13     Fields:    
    7. VEGF-C protects the integrity of the bone marrow perivascular niche in mice. Blood. 2020 10 15; 136(16):1871-1883. Fang S, Chen S, Nurmi H, Leppänen VM, Jeltsch M, Scadden D, Silberstein L, Mikkola H, Alitalo K. PMID: 32842144; PMCID: PMC7568034.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    8. MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment. Nature. 2019 12; 576(7786):281-286. Calvanese V, Nguyen AT, Bolan TJ, Vavilina A, Su T, Lee LK, Wang Y, Lay FD, Magnusson M, Crooks GM, Kurdistani SK, Mikkola HKA. PMID: 31776511; PMCID: PMC7278275.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    9. Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis. Circulation. 2018 09 18; 138(12):1224-1235. Park S, Ranjbarvaziri S, Lay FD, Zhao P, Miller MJ, Dhaliwal JS, Huertas-Vazquez A, Wu X, Qiao R, Soffer JM, Rau C, Wang Y, Mikkola HKA, Lusis AJ, Ardehali R. PMID: 29950403; PMCID: PMC6202226.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    10. Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes. Nat Commun. 2018 09 07; 9(1):3634. Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D. PMID: 30194383; PMCID: PMC6128860.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    11. Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells. Exp Hematol. 2018 09; 65:1-16. Grace CS, Mikkola HKA, Dou DR, Calvanese V, Ronn RE, Purton LE. PMID: 29981365.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    12. Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. Nat Commun. 2018 02 21; 9(1):754. Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R. PMID: 29467410; PMCID: PMC5821855.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    13. Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration. Cell Rep. 2017 Dec 19; 21(12):3514-3523. Komorowska K, Doyle A, Wahlestedt M, Subramaniam A, Debnath S, Chen J, Soneji S, Van Handel B, Mikkola HKA, Miharada K, Bryder D, Larsson J, Magnusson M. PMID: 29262330.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    14. LYVE1 Marks the Divergence of Yolk Sac Definitive Hemogenic Endothelium from the Primitive Erythroid Lineage. Cell Rep. 2016 11 22; 17(9):2286-2298. Lee LK, Ghorbanian Y, Wang W, Wang Y, Kim YJ, Weissman IL, Inlay MA, Mikkola HKA. PMID: 27880904; PMCID: PMC6940422.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    15. Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros. Nat Biotechnol. 2016 Nov; 34(11):1168-1179. Ng ES, Azzola L, Bruveris FF, Calvanese V, Phipson B, Vlahos K, Hirst C, Jokubaitis VJ, Yu QC, Maksimovic J, Liebscher S, Januar V, Zhang Z, Williams B, Conscience A, Durnall J, Jackson S, Costa M, Elliott D, Haylock DN, Nilsson SK, Saffery R, Schenke-Layland K, Oshlack A, Mikkola HK, Stanley EG, Elefanty AG. PMID: 27748754.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    16. MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis. Nat Commun. 2016 08 10; 7:12376. Wang W, Org T, Montel-Hagen A, Pioli PD, Duan D, Israely E, Malkin D, Su T, Flach J, Kurdistani SK, Schiestl RH, Mikkola HK. PMID: 27507714; PMCID: PMC4987520.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    17. Critical requirement of VEGF-C in transition to fetal erythropoiesis. Blood. 2016 08 04; 128(5):710-20. Fang S, Nurmi H, Heinolainen K, Chen S, Salminen E, Saharinen P, Mikkola HK, Alitalo K. PMID: 27343251.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    18. Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol. 2016 06; 18(6):595-606. Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, Sasidharan R, Ramirez CM, Zack JA, Crooks GM, Galic Z, Mikkola HK. PMID: 27183470; PMCID: PMC4981340.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    19. Tracking HSC Origin: From Bench to Placenta. Dev Cell. 2016 Mar 07; 36(5):479-80. Calvanese V, Mikkola HK. PMID: 26954540.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    20. GLI2 inhibition abrogates human leukemia stem cell dormancy. J Transl Med. 2015 Mar 21; 13:98. Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson CH. PMID: 25889765; PMCID: PMC4414375.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    21. Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. EMBO J. 2015 Mar 12; 34(6):759-77. Org T, Duan D, Ferrari R, Montel-Hagen A, Van Handel B, Kerényi MA, Sasidharan R, Rubbi L, Fujiwara Y, Pellegrini M, Orkin SH, Kurdistani SK, Mikkola HK. PMID: 25564442; PMCID: PMC4369313.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    22. GPI-80 defines self-renewal ability in hematopoietic stem cells during human development. Cell Stem Cell. 2015 Jan 08; 16(1):80-7. Prashad SL, Calvanese V, Yao CY, Kaiser J, Wang Y, Sasidharan R, Crooks G, Magnusson M, Mikkola HK. PMID: 25465114; PMCID: PMC4520393.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    23. The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis. Cell Rep. 2014 May 22; 7(4):1239-47. Mishra BP, Zaffuto KM, Artinger EL, Org T, Mikkola HK, Cheng C, Djabali M, Ernst P. PMID: 24813891; PMCID: PMC4120120.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    24. Sex hormone drives blood stem cell reproduction. EMBO J. 2014 Mar 18; 33(6):534-5. Calvanese V, Lee LK, Mikkola HK. PMID: 24562387; PMCID: PMC3989647.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    25. Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell. 2014 Jan 30; 156(3):549-62. Goddard LM, Murphy TJ, Org T, Enciso JM, Hashimoto-Partyka MK, Warren CM, Domigan CK, McDonald AI, He H, Sanchez LA, Allen NC, Orsenigo F, Chao LC, Dejana E, Tontonoz P, Mikkola HK, Iruela-Arispe ML. PMID: 24485460; PMCID: PMC3985399.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    26. c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface. Dev Cell. 2013 Nov 25; 27(4):373-86. Ueno M, Lee LK, Chhabra A, Kim YJ, Sasidharan R, Van Handel B, Wang Y, Kamata M, Kamran P, Sereti KI, Ardehali R, Jiang M, Mikkola HK. PMID: 24286824; PMCID: PMC3950757.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    27. In vivo mapping of notch pathway activity in normal and stress hematopoiesis. Cell Stem Cell. 2013 Aug 01; 13(2):190-204. Oh P, Lobry C, Gao J, Tikhonova A, Loizou E, Manet J, van Handel B, Ibrahim S, Greve J, Mikkola H, Artavanis-Tsakonas S, Aifantis I. PMID: 23791481; PMCID: PMC3902172.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    28. Selective suppression of endothelial cytokine production by progesterone receptor. Vascul Pharmacol. 2013 Jul-Aug; 59(1-2):36-43. Goddard LM, Ton AN, Org T, Mikkola HK, Iruela-Arispe ML. PMID: 23747964; PMCID: PMC3819224.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    29. [An unexpected repressive role for Scl in the embryonic endothelium]. Med Sci (Paris). 2013 Mar; 29(3):257-9. Montel-Hagen A, Van Handel B, Mikkola H. PMID: 23544378.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    30. Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability. PLoS One. 2013; 8(1):e53912. Magnusson M, Sierra MI, Sasidharan R, Prashad SL, Romero M, Saarikoski P, Van Handel B, Huang A, Li X, Mikkola HK. PMID: 23342037; PMCID: PMC3547050.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    31. Haemogenic endocardium contributes to transient definitive haematopoiesis. Nat Commun. 2013; 4:1564. Nakano H, Liu X, Arshi A, Nakashima Y, van Handel B, Sasidharan R, Harmon AW, Shin JH, Schwartz RJ, Conway SJ, Harvey RP, Pashmforoush M, Mikkola HK, Nakano A. PMID: 23463007; PMCID: PMC3612528.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    32. Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo. J Virol. 2013 Feb; 87(4):2094-108. Palomares K, Vigant F, Van Handel B, Pernet O, Chikere K, Hong P, Sherman SP, Patterson M, An DS, Lowry WE, Mikkola HK, Morizono K, Pyle AD, Lee B. PMID: 23192877; PMCID: PMC3571488.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    33. Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLoS One. 2012; 7(10):e45603. Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR. PMID: 23056209; PMCID: PMC3467279.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    34. Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Dev Cell. 2012 Oct 16; 23(4):796-811. Xu J, Shao Z, Glass K, Bauer DE, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos JA, Mikkola HK, Yuan GC, Orkin SH. PMID: 23041383; PMCID: PMC3477283.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansCells
    35. Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. Nat Immunol. 2012 Oct; 13(10):963-71. Kohn LA, Hao QL, Sasidharan R, Parekh C, Ge S, Zhu Y, Mikkola HK, Crooks GM. PMID: 22941246; PMCID: PMC3448017.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    36. Dynamic distribution of linker histone H1.5 in cellular differentiation. PLoS Genet. 2012; 8(8):e1002879. Li JY, Patterson M, Mikkola HK, Lowry WE, Kurdistani SK. PMID: 22956909; PMCID: PMC3431313.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    37. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012 Aug 03; 150(3):590-605. Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK. PMID: 22863011; PMCID: PMC3624753.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    38. Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev Cell. 2012 Mar 13; 22(3):651-9. Chhabra A, Lechner AJ, Ueno M, Acharya A, Van Handel B, Wang Y, Iruela-Arispe ML, Tallquist MD, Mikkola HK. PMID: 22387002; PMCID: PMC3395466.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    39. CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One. 2012; 7(2):e30562. Hall-Glenn F, De Young RA, Huang BL, van Handel B, Hofmann JJ, Chen TT, Choi A, Ong JR, Benya PD, Mikkola H, Iruela-Arispe ML, Lyons KM. PMID: 22363445; PMCID: PMC3282727.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    40. The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo. Cell Death Differ. 2012 Jul; 19(7):1117-26. Hyde BB, Liesa M, Elorza AA, Qiu W, Haigh SE, Richey L, Mikkola HK, Schlaeger TM, Shirihai OS. PMID: 22240895; PMCID: PMC3374075.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    41. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest. 2012 Jan; 122(1):337-47. Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. PMID: 22156197; PMCID: PMC3248291.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    42. Defining the nature of human pluripotent stem cell progeny. Cell Res. 2012 Jan; 22(1):178-93. Patterson M, Chan DN, Ha I, Case D, Cui Y, Van Handel B, Mikkola HK, Lowry WE. PMID: 21844894; PMCID: PMC3351932.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    43. Return to youth with Sox17. Genes Dev. 2011 Aug 01; 25(15):1557-62. Chhabra A, Mikkola HK. PMID: 21828265; PMCID: PMC3182022.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    44. Recapitulation of the embryonic cardiovascular progenitor cell niche. Biomaterials. 2011 Apr; 32(11):2748-56. Schenke-Layland K, Nsair A, Van Handel B, Angelis E, Gluck JM, Votteler M, Goldhaber JI, Mikkola HK, Kahn M, Maclellan WR. PMID: 21257198; PMCID: PMC3414535.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    45. Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells. Blood. 2011 Feb 17; 117(7):2157-65. Huang X, Gschweng E, Van Handel B, Cheng D, Mikkola HK, Witte ON. PMID: 21163928; PMCID: PMC3062325.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    46. The first trimester human placenta is a site for terminal maturation of primitive erythroid cells. Blood. 2010 Oct 28; 116(17):3321-30. Van Handel B, Prashad SL, Hassanzadeh-Kiabi N, Huang A, Magnusson M, Atanassova B, Chen A, Hamalainen EI, Mikkola HK. PMID: 20628147; PMCID: PMC2995359.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    47. Placenta as a newly identified source of hematopoietic stem cells. Curr Opin Hematol. 2010 Jul; 17(4):313-8. Lee LK, Ueno M, Van Handel B, Mikkola HK. PMID: 20571394; PMCID: PMC2929561.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    48. Targeting leukemia stem cells. Nat Biotechnol. 2010 Mar; 28(3):237-8. Mikkola HK, Radu CG, Witte ON. PMID: 20212485.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    49. Hematopoietic stem cell development in the placenta. Int J Dev Biol. 2010; 54(6-7):1089-98. Gekas C, Rhodes KE, Van Handel B, Chhabra A, Ueno M, Mikkola HK. PMID: 20711986; PMCID: PMC4285582.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    50. DNA methylation is a guardian of stem cell self-renewal and multipotency. Nat Genet. 2009 Nov; 41(11):1164-6. Gereige LM, Mikkola HK. PMID: 19862008.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    51. Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells. Stem Cells. 2009 Apr; 27(4):783-95. Park TS, Galic Z, Conway AE, Lindgren A, van Handel BJ, Magnusson M, Richter L, Teitell MA, Mikkola HK, Lowry WE, Plath K, Clark AT. PMID: 19350678; PMCID: PMC4357362.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    52. ESAM: adding to the hematopoietic toolbox. Blood. 2009 Mar 26; 113(13):2871-2. Mikkola H. PMID: 19324907.
      View in: PubMed   Mentions: 1     Fields:    
    53. Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood. 2009 Apr 09; 113(15):3461-71. Gekas C, Rhodes KE, Gereige LM, Helgadottir H, Ferrari R, Kurdistani SK, Montecino-Rodriguez E, Bassel-Duby R, Olson E, Krivtsov AV, Armstrong S, Orkin SH, Pellegrini M, Mikkola HK. PMID: 19211936; PMCID: PMC2945827.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    54. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science. 2008 Dec 19; 322(5909):1839-42. Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH. PMID: 19056937.
      View in: PubMed   Mentions: 462     Fields:    Translation:HumansAnimalsCells
    55. UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008 Nov 07; 283(45):30461-70. Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS. PMID: 18687678; PMCID: PMC2576537.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    56. Isolation and visualization of mouse placental hematopoietic stem cells. Curr Protoc Stem Cell Biol. 2008 Aug; Chapter 2:Unit 2A.8.1-2A.8.14. Gekas C, Rhodes KE, Mikkola HK. PMID: 18729047.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    57. Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. Stem Cells. 2008 Jun; 26(6):1537-46. Schenke-Layland K, Rhodes KE, Angelis E, Butylkova Y, Heydarkhan-Hagvall S, Gekas C, Zhang R, Goldhaber JI, Mikkola HK, Plath K, MacLellan WR. PMID: 18450826; PMCID: PMC2873147.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    58. Hematopoietic stem cells in transit--where's the niche? Cell Stem Cell. 2008 Apr 10; 2(4):302-4. Magnusson M, Mikkola HK. PMID: 18397748.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    59. The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell. 2008 Mar 06; 2(3):252-63. Rhodes KE, Gekas C, Wang Y, Lux CT, Francis CS, Chan DN, Conway S, Orkin SH, Yoder MC, Mikkola HK. PMID: 18371450; PMCID: PMC2888040.
      View in: PubMed   Mentions: 134     Fields:    Translation:AnimalsCells
    60. The hematopoietic stem cell and its niche: a comparative view. Genes Dev. 2007 Dec 01; 21(23):3044-60. Martinez-Agosto JA, Mikkola HK, Hartenstein V, Banerjee U. PMID: 18056420.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    61. Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells. Stem Cells. 2007 Jun; 25(6):1529-38. Schenke-Layland K, Angelis E, Rhodes KE, Heydarkhan-Hagvall S, Mikkola HK, Maclellan WR. PMID: 17363553.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    62. The journey of developing hematopoietic stem cells. Development. 2006 Oct; 133(19):3733-44. Mikkola HK, Orkin SH. PMID: 16968814.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansAnimalsCells
    63. Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development. Pediatr Res. 2006 Apr; 59(4 Pt 2):33R-9R. Teitell MA, Mikkola HK. PMID: 16549546.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    64. Placenta as a site for hematopoietic stem cell development. Exp Hematol. 2005 Sep; 33(9):1048-54. Mikkola HK, Gekas C, Orkin SH, Dieterlen-Lievre F. PMID: 16140153.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    65. The placenta is a niche for hematopoietic stem cells. Dev Cell. 2005 Mar; 8(3):365-75. Gekas C, Dieterlen-Lièvre F, Orkin SH, Mikkola HK. PMID: 15737932.
      View in: PubMed   Mentions: 236     Fields:    Translation:AnimalsCells
    66. Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. Blood. 2005 May 15; 105(10):3871-4. Schlaeger TM, Mikkola HK, Gekas C, Helgadottir HB, Orkin SH. PMID: 15677556.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    67. Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods Mol Med. 2005; 105:3-22. Mikkola HK, Orkin SH. PMID: 15492385.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    68. Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Mol Cell Biol. 2004 Sep; 24(17):7491-502. Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P, Porcher C. PMID: 15314159; PMCID: PMC506978.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    69. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003 Jan 30; 421(6922):547-51. Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH. PMID: 12540851.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    70. Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood. 2003 Jan 15; 101(2):508-16. Mikkola HK, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH. PMID: 12393529.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    71. The search for the hemangioblast. J Hematother Stem Cell Res. 2002 Feb; 11(1):9-17. Mikkola HK, Orkin SH. PMID: 11847000.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    72. Lentiviral-mediated gene transfer into haematopoietic stem cells. J Intern Med. 2001 Apr; 249(4):339-43. Woods NB, Mikkola H, Nilsson E, Olsson K, Trono D, Karlsson S. PMID: 11298854.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    73. Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells. Blood. 2000 Dec 01; 96(12):3725-33. Woods NB, Fahlman C, Mikkola H, Hamaguchi I, Olsson K, Zufferey R, Jacobsen SE, Trono D, Karlsson S. PMID: 11090053.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    74. Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells. J Virol. 2000 Dec; 74(24):11911-8. Mikkola H, Woods NB, Sjögren M, Helgadottir H, Hamaguchi I, Jacobsen SE, Trono D, Karlsson S. PMID: 11090191; PMCID: PMC112474.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    75. Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro. J Virol. 2000 Nov; 74(22):10778-84. Hamaguchi I, Woods NB, Panagopoulos I, Andersson E, Mikkola H, Fahlman C, Zufferey R, Carlsson L, Trono D, Karlsson S. PMID: 11044122; PMCID: PMC110952.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    76. Val34Leu polymorphism of plasma factor XIII: biochemistry and epidemiology in familial thrombophilia. Blood. 2000 Oct 01; 96(7):2479-86. Balogh I, Szôke G, Kárpáti L, Wartiovaara U, Katona E, Komáromi I, Haramura G, Pfliegler G, Mikkola H, Muszbek L. PMID: 11001900.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    77. Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation. Thromb Haemost. 1998 Jul; 80(1):171-5. Wartiovaara U, Salven P, Mikkola H, Lassila R, Kaukonen J, Joukov V, Orpana A, Ristimäki A, Heikinheimo M, Joensuu H, Alitalo K, Palotie A. PMID: 9684805.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    78. Molecular mechanism of a mild phenotype in coagulation factor XIII (FXIII) deficiency: a splicing mutation permitting partial correct splicing of FXIII A-subunit mRNA. Blood. 1997 Feb 15; 89(4):1279-87. Mikkola H, Muszbek L, Laiho E, Syrjälä M, Hämäläinen E, Haramura G, Salmi T, Peltonen L, Palotie A. PMID: 9028951.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    79. Four novel mutations in deficiency of coagulation factor XIII: consequences to expression and structure of the A-subunit. Blood. 1996 Jan 01; 87(1):141-51. Mikkola H, Yee VC, Syrjälä M, Seitz R, Egbring R, Petrini P, Ljung R, Ingerslev J, Teller DC, Peltonen L, Palotie A. PMID: 8547636.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    80. Deficiency in the A-subunit of coagulation factor XIII: two novel point mutations demonstrate different effects on transcript levels. Blood. 1994 Jul 15; 84(2):517-25. Mikkola H, Syrjälä M, Rasi V, Vahtera E, Hämäläinen E, Peltonen L, Palotie A. PMID: 8025280.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
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