Owen N Witte

Title(s)Professor, MIMG
SchoolMedicine
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    Other Positions
    Title(s)Professor, Molecular and Medical Pharmacology


    Collapse Research 
    Collapse Research Activities and Funding
    Targeting alternative splicing for TCR discovery in small cell carcinomas
    NIH U01CA233074Sep 21, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Targeting Genomic Instability in Lethal Neuroendocrine Prostate Cancer
    NIH R01CA222877Jun 6, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Multi-omic analysis of Myc-driven splicing for prostate cancer therapeutic development
    NIH R01CA220238Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Influences of the Microenvironment on Cancer Stem Cells
    NIH U01CA164188Sep 15, 2011 - Aug 31, 2017
    Role: Principal Investigator
    ABL ONCOGENE AND MURINE AND HUMAN LEUKEMIAS
    NIH R01CA076204Mar 1, 1998 - Feb 28, 2004
    Role: Principal Investigator
    ROLE OF THE ABL ONCOGENE IN MURINE &HUMAN LEUKEMIAS
    NIH R35CA053867May 15, 1991 - Apr 30, 1998
    Role: Principal Investigator
    MOLECULAR DIAGNOSIS OF CHRONIC MYELOGENOUS LEUKEMIA
    NIH R01CA040957Sep 1, 1985 - Feb 28, 1989
    Role: Principal Investigator
    UCLA-Caltech Medical Scientist Training Program
    NIH T32GM008042Jul 1, 1983 - Jun 30, 2024
    Role: Co-Principal Investigator
    Tumor Cell Biology Training Program
    NIH T32CA009056Jul 1, 1980 - Jul 31, 2022
    Role: Co-Principal Investigator
    TRANSFORMATION BY ABELSON MURINE LEUKEMIA VIRUS
    NIH R01CA027507May 1, 1980 - Apr 30, 1991
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Defining T cell receptor repertoires using nanovial-based binding and functional screening. Proc Natl Acad Sci U S A. 2024 Apr 02; 121(14):e2320442121. Koo D, Mao Z, Dimatteo R, Noguchi M, Tsubamoto N, McLaughlin J, Tran W, Lee S, Cheng D, de Rutte J, Burton Sojo G, Witte ON, Di Carlo D. PMID: 38536748.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation. Cancer Cell. 2023 12 11; 41(12):2066-2082.e9. Chen CC, Tran W, Song K, Sugimoto T, Obusan MB, Wang L, Sheu KM, Cheng D, Ta L, Varuzhanyan G, Huang A, Xu R, Zeng Y, Borujerdpur A, Bayley NA, Noguchi M, Mao Z, Morrissey C, Corey E, Nelson PS, Zhao Y, Huang J, Park JW, Witte ON, Graeber TG. PMID: 37995683; PMCID: PMC10878415.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis. iScience. 2023 Dec 15; 26(12):108480. Ta L, Tsai BL, Deng W, Sha J, Varuzhanyan G, Tran W, Wohlschlegel JA, Carr-Ascher JR, Witte ON. PMID: 38089570; PMCID: PMC10711388.
      View in: PubMed   Mentions:
    4. Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy. Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47):e2312374120. Bangayan NJ, Wang L, Burton Sojo G, Noguchi M, Cheng D, Ta L, Gunn D, Mao Z, Liu S, Yin Q, Riedinger M, Li K, Wu AM, Stoyanova T, Witte ON. PMID: 37963244; PMCID: PMC10666036.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer. Cancer Res. 2023 08 15; 83(16):2763-2774. Lundberg A, Zhang M, Aggarwal R, Li H, Zhang L, Foye A, Sjöström M, Chou J, Chang K, Moreno-Rodriguez T, Shrestha R, Baskin A, Zhu X, Weinstein AS, Younger N, Alumkal JJ, Beer TM, Chi KN, Evans CP, Gleave M, Lara PN, Reiter RE, Rettig MB, Witte ON, Wyatt AW, Feng FY, Small EJ, Quigley DA. PMID: 37289025; PMCID: PMC10425725.
      View in: PubMed   Mentions: 6     Fields:    
    6. The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells. Proc Natl Acad Sci U S A. 2023 07 11; 120(28):e2220190120. Chen X, Yang HT, Zhang B, Phillips JW, Cheng D, Rigo F, Witte ON, Xing Y, Black DL. PMID: 37399401; PMCID: PMC10334793.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing. Proc Natl Acad Sci U S A. 2023 05 23; 120(21):e2221116120. Pan Y, Phillips JW, Zhang BD, Noguchi M, Kutschera E, McLaughlin J, Nesterenko PA, Mao Z, Bangayan NJ, Wang R, Tran W, Yang HT, Wang Y, Xu Y, Obusan MB, Cheng D, Lee AH, Kadash-Edmondson KE, Champhekar A, Puig-Saus C, Ribas A, Prins RM, Seet CS, Crooks GM, Witte ON, Xing Y. PMID: 37192158; PMCID: PMC10214192.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Defining T cell receptor repertoires using nanovial-based affinity and functional screening. bioRxiv. 2023 Jan 20. Koo D, Mao Z, Dimatteo R, Tsubamoto N, Noguchi M, McLaughlin J, Tran W, Lee S, Cheng D, de Rutte J, Sojo GB, Witte ON, Di Carlo D. PMID: 36711524; PMCID: PMC9882161.
      View in: PubMed   Mentions:
    9. The 5-Hydroxymethylcytosine Landscape of Prostate Cancer. Cancer Res. 2022 11 02; 82(21):3888-3902. Sjöström M, Zhao SG, Levy S, Zhang M, Ning Y, Shrestha R, Lundberg A, Herberts C, Foye A, Aggarwal R, Hua JT, Li H, Bergamaschi A, Maurice-Dror C, Maheshwari A, Chen S, Ng SWS, Ye W, Petricca J, Fraser M, Chesner L, Perry MD, Moreno-Rodriguez T, Chen WS, Alumkal JJ, Chou J, Morgans AK, Beer TM, Thomas GV, Gleave M, Lloyd P, Phillips T, McCarthy E, Haffner MC, Zoubeidi A, Annala M, Reiter RE, Rettig MB, Witte ON, Fong L, Bose R, Huang FW, Luo J, Bjartell A, Lang JM, Mahajan NP, Lara PN, Evans CP, Tran PT, Posadas EM, He C, Cui XL, Huang J, Zwart W, Gilbert LA, Maher CA, Boutros PC, Chi KN, Ashworth A, Small EJ, He HH, Wyatt AW, Quigley DA, Feng FY. PMID: 36251389; PMCID: PMC9627125.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    10. Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity. Nat Commun. 2022 09 15; 13(1):5345. Westbrook TC, Guan X, Rodansky E, Flores D, Liu CJ, Udager AM, Patel RA, Haffner MC, Hu YM, Sun D, Beer TM, Foye A, Aggarwal R, Quigley DA, Youngren JF, Ryan CJ, Gleave M, Wang Y, Huang J, Coleman I, Morrissey C, Nelson PS, Evans CP, Lara P, Reiter RE, Witte O, Rettig M, Wong CK, Weinstein AS, Uzunangelov V, Stuart JM, Thomas GV, Feng FY, Small EJ, Yates JA, Xia Z, Alumkal JJ. PMID: 36109521; PMCID: PMC9477876.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis. Immunology. 2023 01; 168(1):152-169. Chen BY, Salas JR, Trias AO, Perez Rodriguez A, Tsang JE, Guemes M, Le TM, Galic Z, Shepard HM, Steinman L, Nathanson DA, Czernin J, Witte ON, Radu CG, Schultz KA, Clark PM. PMID: 35986643; PMCID: PMC9844239.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation. Proc Natl Acad Sci U S A. 2022 08 02; 119(31):e2203410119. Mao Z, Nesterenko PA, McLaughlin J, Deng W, Burton Sojo G, Cheng D, Noguchi M, Chour W, DeLucia DC, Finton KA, Qin Y, Obusan MB, Tran W, Wang L, Bangayan NJ, Ta L, Chen CC, Seet CS, Crooks GM, Phillips JW, Heath JR, Strong RK, Lee JK, Wohlschlegel JA, Witte ON. PMID: 35878026; PMCID: PMC9351518.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. HLA-A∗02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses. Cell Rep. 2021 12 28; 37(13):110167. Nesterenko PA, McLaughlin J, Tsai BL, Burton Sojo G, Cheng D, Zhao D, Mao Z, Bangayan NJ, Obusan MB, Su Y, Ng RH, Chour W, Xie J, Li YR, Lee D, Noguchi M, Carmona C, Phillips JW, Kim JT, Yang L, Heath JR, Boutros PC, Witte ON. PMID: 34919800; PMCID: PMC8660260.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    14. Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy. Cell Rep Med. 2021 11 16; 2(11):100449. Li YR, Zhou Y, Kim YJ, Zhu Y, Ma F, Yu J, Wang YC, Chen X, Li Z, Zeng S, Wang X, Lee D, Ku J, Tsao T, Hardoy C, Huang J, Cheng D, Montel-Hagen A, Seet CS, Crooks GM, Larson SM, Sasine JP, Wang X, Pellegrini M, Ribas A, Kohn DB, Witte O, Wang P, Yang L. PMID: 34841295; PMCID: PMC8607011.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    15. RNA Dysregulation: An Expanding Source of Cancer Immunotherapy Targets. Trends Pharmacol Sci. 2021 04; 42(4):268-282. Pan Y, Kadash-Edmondson KE, Wang R, Phillips J, Liu S, Ribas A, Aplenc R, Witte ON, Xing Y. PMID: 33711255; PMCID: PMC8761020.
      View in: PubMed   Mentions: 23     Fields:    
    16. Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning. Proc Natl Acad Sci U S A. 2021 01 19; 118(3). Nesterenko PA, McLaughlin J, Cheng D, Bangayan NJ, Burton Sojo G, Seet CS, Qin Y, Mao Z, Obusan MB, Phillips JW, Witte ON. PMID: 33431692; PMCID: PMC7826406.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    17. The DNA methylation landscape of advanced prostate cancer. Nat Genet. 2020 08; 52(8):778-789. Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY. PMID: 32661416; PMCID: PMC7454228.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    18. Targeting RET Kinase in Neuroendocrine Prostate Cancer. Mol Cancer Res. 2020 08; 18(8):1176-1188. VanDeusen HR, Ramroop JR, Morel KL, Bae SY, Sheahan AV, Sychev Z, Lau NA, Cheng LC, Tan VM, Li Z, Petersen A, Lee JK, Park JW, Yang R, Hwang JH, Coleman I, Witte ON, Morrissey C, Corey E, Nelson PS, Ellis L, Drake JM. PMID: 32461304; PMCID: PMC7415621.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    19. Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance. Proc Natl Acad Sci U S A. 2020 06 02; 117(22):12315-12323. Alumkal JJ, Sun D, Lu E, Beer TM, Thomas GV, Latour E, Aggarwal R, Cetnar J, Ryan CJ, Tabatabaei S, Bailey S, Turina CB, Quigley DA, Guan X, Foye A, Youngren JF, Urrutia J, Huang J, Weinstein AS, Friedl V, Rettig M, Reiter RE, Spratt DE, Gleave M, Evans CP, Stuart JM, Chen Y, Feng FY, Small EJ, Witte ON, Xia Z. PMID: 32424106; PMCID: PMC7275746.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCTClinical Trials
    20. Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5269-5279. Phillips JW, Pan Y, Tsai BL, Xie Z, Demirdjian L, Xiao W, Yang HT, Zhang Y, Lin CH, Cheng D, Hu Q, Liu S, Black DL, Witte ON, Xing Y. PMID: 32086391; PMCID: PMC7071906.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    21. A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):563-572. Wang L, Smith BA, Balanis NG, Tsai BL, Nguyen K, Cheng MW, Obusan MB, Esedebe FN, Patel SJ, Zhang H, Clark PM, Sisk AE, Said JW, Huang J, Graeber TG, Witte ON, Chin AI, Park JW. PMID: 31871155; PMCID: PMC6955337.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. Sci Transl Med. 2019 12 04; 11(521). Li Y, He Y, Butler W, Xu L, Chang Y, Lei K, Zhang H, Zhou Y, Gao AC, Zhang Q, Taylor DG, Cheng D, Farber-Katz S, Karam R, Landrith T, Li B, Wu S, Hsuan V, Yang Q, Hu H, Chen X, Flowers M, McCall SJ, Lee JK, Smith BA, Park JW, Goldstein AS, Witte ON, Wang Q, Rettig MB, Armstrong AJ, Cheng Q, Huang J. PMID: 31801883; PMCID: PMC7238624.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    23. 18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis. J Nucl Med. 2020 05; 61(5):757-763. Chen BY, Ghezzi C, Villegas B, Quon A, Radu CG, Witte ON, Clark PM. PMID: 31653711; PMCID: PMC7198381.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    24. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. 2019 10 03; 25(4):542-557.e9. Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, McLaughlin J, Cheng D, Hollis RP, Campo-Fernandez B, Urbinati F, Wei L, Pang L, Rezek V, Berent-Maoz B, Macabali MH, Gjertson D, Wang X, Galic Z, Kitchen SG, An DS, Hu-Lieskovan S, Kaplan-Lefko PJ, De Oliveira SN, Seet CS, Larson SM, Forman SJ, Heath JR, Zack JA, Crooks GM, Radu CG, Ribas A, Kohn DB, Witte ON, Yang L. PMID: 31495780; PMCID: PMC7018522.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    25. Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood. Cell Rep. 2019 09 03; 28(10):2728-2738.e7. Peng S, Zaretsky JM, Ng AHC, Chour W, Bethune MT, Choi J, Hsu A, Holman E, Ding X, Guo K, Kim J, Xu AM, Heath JE, Noh WJ, Zhou J, Su Y, Lu Y, McLaughlin J, Cheng D, Witte ON, Baltimore D, Ribas A, Heath JR. PMID: 31484081; PMCID: PMC6774618.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    26. Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies. Cancer Cell. 2019 07 08; 36(1):17-34.e7. Balanis NG, Sheu KM, Esedebe FN, Patel SJ, Smith BA, Park JW, Alhani S, Gomperts BN, Huang J, Witte ON, Graeber TG. PMID: 31287989; PMCID: PMC6703903.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    27. MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer. Prostate Cancer Prostatic Dis. 2019 12; 22(4):531-538. Nickols NG, Nazarian R, Zhao SG, Tan V, Uzunangelov V, Xia Z, Baertsch R, Neeman E, Gao AC, Thomas GV, Howard L, De Hoedt AM, Stuart J, Goldstein T, Chi K, Gleave ME, Graff JN, Beer TM, Drake JM, Evans CP, Aggarwal R, Foye A, Feng FY, Small EJ, Aronson WJ, Freedland SJ, Witte ON, Huang J, Alumkal JJ, Reiter RE, Rettig MB. PMID: 30804427; PMCID: PMC6853839.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    28. T cell antigen discovery via trogocytosis. Nat Methods. 2019 02; 16(2):183-190. Li G, Bethune MT, Wong S, Joglekar AV, Leonard MT, Wang JK, Kim JT, Cheng D, Peng S, Zaretsky JM, Su Y, Luo Y, Heath JR, Ribas A, Witte ON, Baltimore D. PMID: 30700903; PMCID: PMC6719556.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    29. IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System. Clin Cancer Res. 2019 02 01; 25(3):1000-1011. Puig-Saus C, Parisi G, Garcia-Diaz A, Krystofinski PE, Sandoval S, Zhang R, Champhekar AS, McCabe J, Cheung-Lau GC, Truong NA, Vega-Crespo A, Komenan MDS, Pang J, Macabali MH, Saco JD, Goodwin JL, Bolon B, Seet CS, Montel-Hagen A, Crooks GM, Hollis RP, Campo-Fernandez B, Bischof D, Cornetta K, Gschweng EH, Adelson C, Nguyen A, Yang L, Witte ON, Baltimore D, Comin-Anduix B, Kohn DB, Wang X, Cabrera P, Kaplan-Lefko PJ, Berent-Maoz B, Ribas A. PMID: 30409823; PMCID: PMC6359988.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    30. Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10702-E10711. Bethune MT, Li XH, Yu J, McLaughlin J, Cheng D, Mathis C, Moreno BH, Woods K, Knights AJ, Garcia-Diaz A, Wong S, Hu-Lieskovan S, Puig-Saus C, Cebon J, Ribas A, Yang L, Witte ON, Baltimore D. PMID: 30348802; PMCID: PMC6233129.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    31. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 2018 10 18; 175(3):889. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY. PMID: 30340047.
      View in: PubMed   Mentions: 64     Fields:    
    32. Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Science. 2018 10 05; 362(6410):91-95. Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON. PMID: 30287662; PMCID: PMC6414229.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansCells
    33. A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers. Cell Rep. 2018 09 18; 24(12):3353-3366.e5. Smith BA, Balanis NG, Nanjundiah A, Sheu KM, Tsai BL, Zhang Q, Park JW, Thompson M, Huang J, Witte ON, Graeber TG. PMID: 30232014; PMCID: PMC6382070.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    34. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 2018 07 26; 174(3):758-769.e9. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY. PMID: 30033370; PMCID: PMC6425931.
      View in: PubMed   Mentions: 263     Fields:    Translation:HumansCells
    35. Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study. J Clin Oncol. 2018 08 20; 36(24):2492-2503. Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, Rettig M, Wong CK, True L, Foye A, Playdle D, Ryan CJ, Lara P, Chi KN, Uzunangelov V, Sokolov A, Newton Y, Beltran H, Demichelis F, Rubin MA, Stuart JM, Small EJ. PMID: 29985747; PMCID: PMC6366813.
      View in: PubMed   Mentions: 303     Fields:    Translation:HumansCellsCTClinical Trials
    36. 18F-FAC PET Selectively Images Liver-Infiltrating CD4 and CD8 T Cells in a Mouse Model of Autoimmune Hepatitis. J Nucl Med. 2018 10; 59(10):1616-1623. Salas JR, Chen BY, Wong A, Cheng D, Van Arnam JS, Witte ON, Clark PM. PMID: 29700125; PMCID: PMC6167535.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    37. Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Proc Natl Acad Sci U S A. 2018 05 08; 115(19):E4473-E4482. Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON. PMID: 29686080; PMCID: PMC5949005.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    38. Noninvasive Imaging of Drug-Induced Liver Injury with 18F-DFA PET. J Nucl Med. 2018 08; 59(8):1308-1315. Salas JR, Chen BY, Wong A, Duarte S, Angarita SAK, Lipshutz GS, Witte ON, Clark PM. PMID: 29496991; PMCID: PMC6071498.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    39. FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate. Mod Pathol. 2017 09; 30(9):1262-1272. Park JW, Lee JK, Witte ON, Huang J. PMID: 28621319; PMCID: PMC6330177.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    40. Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL. J Exp Med. 2017 03 06; 214(3):793-814. Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M. PMID: 28190001; PMCID: PMC5339667.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    41. Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome. Cell Rep. 2016 12 06; 17(10):2596-2606. Liu X, Grogan TR, Hieronymus H, Hashimoto T, Mottahedeh J, Cheng D, Zhang L, Huang K, Stoyanova T, Park JW, Shkhyan RO, Nowroozizadeh B, Rettig MB, Sawyers CL, Elashoff D, Horvath S, Huang J, Witte ON, Goldstein AS. PMID: 27926864; PMCID: PMC5367888.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    42. Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer: Update on the Stand Up 2 Cancer/Prostate Cancer Foundation-Supported West Coast Prostate Cancer Dream Team. Eur Urol Focus. 2016 Dec; 2(5):469-471. Aggarwal R, Beer TM, Gleave M, Stuart JM, Rettig M, Evans CP, Youngren J, Alumkal JJ, Huang J, Thomas G, Witte O, Small EJ. PMID: 28723508.
      View in: PubMed   Mentions: 9     Fields:    
    43. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6457-E6466. Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter RE, Pitteri SJ, Huang J, Witte ON. PMID: 27694579; PMCID: PMC5081658.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    44. Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell. 2016 Aug 11; 166(4):1041-1054. Drake JM, Paull EO, Graham NA, Lee JK, Smith BA, Titz B, Stoyanova T, Faltermeier CM, Uzunangelov V, Carlin DE, Fleming DT, Wong CK, Newton Y, Sudha S, Vashisht AA, Huang J, Wohlschlegel JA, Graeber TG, Witte ON, Stuart JM. PMID: 27499020; PMCID: PMC4985183.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    45. Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4482-7. Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON. PMID: 27044116; PMCID: PMC4843433.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    46. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 2016 Apr 11; 29(4):536-547. Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON. PMID: 27050099; PMCID: PMC4829466.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansAnimalsCells
    47. [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4027-32. Kim W, Le TM, Wei L, Poddar S, Bazzy J, Wang X, Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D, Gipson RM, Slavik R, Cabebe AE, Taechariyakul T, Yaghoubi SS, Lee JT, Sadeghi S, Lavie A, Faull KF, Witte ON, Donahue TR, Phelps ME, Herschman HR, Herrmann K, Czernin J, Radu CG. PMID: 27035974; PMCID: PMC4839461.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    48. Tissue Recombination Models for the Study of Epithelial Cancer. Cold Spring Harb Protoc. 2015 Dec 02; 2015(12):pdb.top069880. Zong Y, Goldstein AS, Witte ON. PMID: 26631129.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    49. Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):E172-81. Faltermeier CM, Drake JM, Clark PM, Smith BA, Zong Y, Volpe C, Mathis C, Morrissey C, Castor B, Huang J, Witte ON. PMID: 26621741; PMCID: PMC4720329.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    50. An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy. Cancer Res. 2016 Jan 01; 76(1):73-82. Tavaré R, Escuin-Ordinas H, Mok S, McCracken MN, Zettlitz KA, Salazar FB, Witte ON, Ribas A, Wu AM. PMID: 26573799; PMCID: PMC4703530.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimalsCells
    51. Lift NIH restrictions on chimera research. Science. 2015 Nov 06; 350(6261):640. Sharma A, Sebastiano V, Scott CT, Magnus D, Koyano-Nakagawa N, Garry DJ, Witte ON, Nakauchi H, Wu JC, Weissman IL, Wu SM. PMID: 26542560.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    52. Dissociated Prostate Regeneration under the Renal Capsule. Cold Spring Harb Protoc. 2015 Nov 02; 2015(11):991-4. Zong Y, Goldstein AS, Witte ON. PMID: 26527760.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    53. Preparation of Urogenital Sinus Mesenchymal Cells for Prostate Tissue Recombination Models. Cold Spring Harb Protoc. 2015 Nov 02; 2015(11):988-90. Zong Y, Goldstein AS, Witte ON. PMID: 26527759.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    54. A basal stem cell signature identifies aggressive prostate cancer phenotypes. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6544-52. Smith BA, Sokolov A, Uzunangelov V, Baertsch R, Newton Y, Graim K, Mathis C, Cheng D, Stuart JM, Witte ON. PMID: 26460041; PMCID: PMC4664352.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    55. DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis. Cancer Cell. 2015 Jul 13; 28(1):97-113. Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes RJ, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE. PMID: 26175416; PMCID: PMC4531387.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    56. Development of 2-Deoxy-2-[(18)F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo. J Med Chem. 2015 Jul 23; 58(14):5538-47. Evdokimov NM, Clark PM, Flores G, Chai T, Faull KF, Phelps ME, Witte ON, Jung ME. PMID: 26102222.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    57. Immuno-PET of Murine T Cell Reconstitution Postadoptive Stem Cell Transplantation Using Anti-CD4 and Anti-CD8 Cys-Diabodies. J Nucl Med. 2015 Aug; 56(8):1258-64. Tavaré R, McCracken MN, Zettlitz KA, Salazar FB, Olafsen T, Witte ON, Wu AM. PMID: 25952734; PMCID: PMC4859343.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    58. Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging. J Clin Invest. 2015 May; 125(5):1815-26. McCracken MN, Vatakis DN, Dixit D, McLaughlin J, Zack JA, Witte ON. PMID: 25822024; PMCID: PMC4463193.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    59. Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1523-8. Smith DJ, Liu S, Ji S, Li B, McLaughlin J, Cheng D, Witte ON, Yang L. PMID: 25605948; PMCID: PMC4321292.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    60. Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. PLoS One. 2014; 9(8):e104125. Bunimovich YL, Nair-Gill E, Riedinger M, McCracken MN, Cheng D, McLaughlin J, Radu CG, Witte ON. PMID: 25101980; PMCID: PMC4125169.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    61. HSV-sr39TK positron emission tomography and suicide gene elimination of human hematopoietic stem cells and their progeny in humanized mice. Cancer Res. 2014 Sep 15; 74(18):5173-83. Gschweng EH, McCracken MN, Kaufman ML, Ho M, Hollis RP, Wang X, Saini N, Koya RC, Chodon T, Ribas A, Witte ON, Kohn DB. PMID: 25038231; PMCID: PMC4167467.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    62. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):E2866-74. Clark PM, Flores G, Evdokimov NM, McCracken MN, Chai T, Nair-Gill E, O'Mahony F, Beaven SW, Faull KF, Phelps ME, Jung ME, Witte ON. PMID: 24982199; PMCID: PMC4104878.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    63. Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clin Cancer Res. 2014 May 01; 20(9):2457-65. Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, Gjertson DW, Cochran AJ, Cornetta K, Wong DJ, Kaplan-Lefko P, Hamid O, Samlowski W, Cohen PA, Daniels GA, Mukherji B, Yang L, Zack JA, Kohn DB, Heath JR, Glaspy JA, Witte ON, Baltimore D, Economou JS, Ribas A. PMID: 24634374; PMCID: PMC4070853.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    64. Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer. Mol Cell Biol. 2014 May; 34(10):1722-32. Drake JM, Lee JK, Witte ON. PMID: 24567371; PMCID: PMC4019040.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    65. Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1108-13. Tavaré R, McCracken MN, Zettlitz KA, Knowles SM, Salazar FB, Olafsen T, Witte ON, Wu AM. PMID: 24390540; PMCID: PMC3903195.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    66. Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20111-6. Stoyanova T, Cooper AR, Drake JM, Liu X, Armstrong AJ, Pienta KJ, Zhang H, Kohn DB, Huang J, Witte ON, Goldstein AS. PMID: 24282295; PMCID: PMC3864278.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    67. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):E4762-9. Drake JM, Graham NA, Lee JK, Stoyanova T, Faltermeier CM, Sud S, Titz B, Huang J, Pienta KJ, Graeber TG, Witte ON. PMID: 24248375; PMCID: PMC3856845.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    68. Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo. Mol Cancer Ther. 2013 Dec; 12(12):2917-28. Janzen DM, Paik DY, Rosales MA, Yep B, Cheng D, Witte ON, Kayadibi H, Ryan CM, Jung ME, Faull K, Memarzadeh S. PMID: 24222661; PMCID: PMC3904550.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    69. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct; 14(10):1073-83. Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. PMID: 24013668; PMCID: PMC3800053.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    70. Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity. PLoS One. 2013; 8(7):e68916. Zangle TA, Burnes D, Mathis C, Witte ON, Teitell MA. PMID: 23935904; PMCID: PMC3720853.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    71. Interleukin-6 and oncostatin-M synergize with the PI3K/AKT pathway to promote aggressive prostate malignancy in mouse and human tissues. Mol Cancer Res. 2013 Oct; 11(10):1159-65. Smith DA, Kiba A, Zong Y, Witte ON. PMID: 23867565; PMCID: PMC3800471.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    72. Does the microenvironment influence the cell types of origin for prostate cancer? Genes Dev. 2013 Jul 15; 27(14):1539-44. Goldstein AS, Witte ON. PMID: 23873937; PMCID: PMC3731542.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    73. Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy. Cancer Res. 2013 Aug 01; 73(15):4697-710. Janzen DM, Rosales MA, Paik DY, Lee DS, Smith DA, Witte ON, Iruela-Arispe ML, Memarzadeh S. PMID: 23744837; PMCID: PMC3752407.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    74. Application of a rapid, simple, and accurate adenovirus-based method to compare PET reporter gene/PET reporter probe systems. Mol Imaging Biol. 2013 Jun; 15(3):273-81. Gil JS, Machado HB, Campbell DO, McCracken M, Radu C, Witte ON, Herschman HR. PMID: 23054556; PMCID: PMC3833443.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    75. Estrogen and progesterone together expand murine endometrial epithelial progenitor cells. Stem Cells. 2013 Apr; 31(4):808-22. Janzen DM, Cheng D, Schafenacker AM, Paik DY, Goldstein AS, Witte ON, Jaroszewicz A, Pellegrini M, Memarzadeh S. PMID: 23341289; PMCID: PMC3774116.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    76. Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy. Cancer Discov. 2013 Apr; 3(4):418-29. Ma C, Cheung AF, Chodon T, Koya RC, Wu Z, Ng C, Avramis E, Cochran AJ, Witte ON, Baltimore D, Chmielowski B, Economou JS, Comin-Anduix B, Ribas A, Heath JR. PMID: 23519018; PMCID: PMC3716460.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCellsCTClinical Trials
    77. Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells. Mol Ther. 2013 May; 21(5):1044-54. Giannoni F, Hardee CL, Wherley J, Gschweng E, Senadheera S, Kaufman ML, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte ON, Economou JS, Ribas A, Kohn DB. PMID: 23380815; PMCID: PMC3666644.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    78. Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1857-62. McCracken MN, Gschweng EH, Nair-Gill E, McLaughlin J, Cooper AR, Riedinger M, Cheng D, Nosala C, Kohn DB, Witte ON. PMID: 23319634; PMCID: PMC3562822.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    79. Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Cancer Discov. 2012 Dec; 2(12):1109-17. Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR. PMID: 23230188; PMCID: PMC3531869.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    80. Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):E3395-404. Zong Y, Huang J, Sankarasharma D, Morikawa T, Fukayama M, Epstein JI, Chada KK, Witte ON. PMID: 23184966; PMCID: PMC3528570.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    81. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med. 2012 Nov 19; 209(12):2215-28. Austin WR, Armijo AL, Campbell DO, Singh AS, Hsieh T, Nathanson D, Herschman HR, Phelps ME, Witte ON, Czernin J, Radu CG. PMID: 23148236; PMCID: PMC3501349.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    82. A plethora of progenitors in the post-natal prostate. EMBO Rep. 2012 Dec; 13(12):1036-7. Goldstein AS, Witte ON. PMID: 23138032; PMCID: PMC3512412.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    83. Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation. Stem Cells. 2012 Nov; 30(11):2487-97. Paik DY, Janzen DM, Schafenacker AM, Velasco VS, Shung MS, Cheng D, Huang J, Witte ON, Memarzadeh S. PMID: 22911892; PMCID: PMC4442093.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    84. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. Genes Dev. 2012 Oct 15; 26(20):2271-85. Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON. PMID: 23070813; PMCID: PMC3475800.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    85. Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PLoS One. 2012; 7(8):e42564. Jiao J, Hindoyan A, Wang S, Tran LM, Goldstein AS, Lawson D, Chen D, Li Y, Guo C, Zhang B, Fazli L, Gleave M, Witte ON, Garraway IP, Wu H. PMID: 22880034; PMCID: PMC3411798.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    86. Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer. Cancer Res. 2012 Sep 15; 72(18):4672-81. Cai H, Memarzadeh S, Stoyanova T, Beharry Z, Kraft AS, Witte ON. PMID: 22805308; PMCID: PMC3445707.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    87. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. 1993. J Immunol. 2012 Apr 01; 188(7):2936-47. Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T, Quan S, Belmont JW, Cooper MD, Conley ME, Witte ON. PMID: 22442491.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    88. Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1643-8. Drake JM, Graham NA, Stoyanova T, Sedghi A, Goldstein AS, Cai H, Smith DA, Zhang H, Komisopoulou E, Huang J, Graeber TG, Witte ON. PMID: 22307624; PMCID: PMC3277127.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    89. Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway. PLoS One. 2011; 6(11):e27586. Chen A, Dong L, Leffler NR, Asch AS, Witte ON, Yang LV. PMID: 22110680; PMCID: PMC3217975.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    90. Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7962-7. Memarzadeh S, Cai H, Janzen DM, Xin L, Lukacs R, Riedinger M, Zong Y, DeGendt K, Verhoeven G, Huang J, Witte ON. PMID: 21518863; PMCID: PMC3093518.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    91. Purification and direct transformation of epithelial progenitor cells from primary human prostate. Nat Protoc. 2011 May; 6(5):656-67. Goldstein AS, Drake JM, Burnes DL, Finley DS, Zhang H, Reiter RE, Huang J, Witte ON. PMID: 21527922; PMCID: PMC3092477.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    92. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6579-84. Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON. PMID: 21464326; PMCID: PMC3080985.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    93. A two-step toward personalized therapies for prostate cancer. Sci Transl Med. 2011 Mar 02; 3(72):72ps7. Goldstein AS, Zong Y, Witte ON. PMID: 21368221; PMCID: PMC3089975.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    94. An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells. Nat Commun. 2011 Jan 25; 2:167. Tsutsui H, Valamehr B, Hindoyan A, Qiao R, Ding X, Guo S, Witte ON, Liu X, Ho CM, Wu H. PMID: 21266967; PMCID: PMC3161511.
      View in: PubMed   Mentions: 84     Fields:    
    95. Photothermal nanoblade for large cargo delivery into mammalian cells. Anal Chem. 2011 Feb 15; 83(4):1321-7. Wu TH, Teslaa T, Kalim S, French CT, Moghadam S, Wall R, Miller JF, Witte ON, Teitell MA, Chiou PY. PMID: 21247066; PMCID: PMC3166650.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    96. Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells. Blood. 2011 Feb 17; 117(7):2157-65. Huang X, Gschweng E, Van Handel B, Cheng D, Mikkola HK, Witte ON. PMID: 21163928; PMCID: PMC3062325.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    97. Invasive prostate carcinoma driven by c-Src and androgen receptor synergy. Cancer Res. 2011 Feb 01; 71(3):862-72. Cai H, Babic I, Wei X, Huang J, Witte ON. PMID: 21135112; PMCID: PMC3032821.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    98. Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway. Eur J Nucl Med Mol Imaging. 2011 Apr; 38(4):711-21. Schwarzenberg J, Radu CG, Benz M, Fueger B, Tran AQ, Phelps ME, Witte ON, Satyamurthy N, Czernin J, Schiepers C. PMID: 21127859; PMCID: PMC3053458.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCTClinical Trials
    99. Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell. 2010 Dec 03; 7(6):682-93. Lukacs RU, Memarzadeh S, Wu H, Witte ON. PMID: 21112563; PMCID: PMC3019762.
      View in: PubMed   Mentions: 154     Fields:    Translation:AnimalsCells
    100. Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17298-303. Memarzadeh S, Zong Y, Janzen DM, Goldstein AS, Cheng D, Kurita T, Schafenacker AM, Huang J, Witte ON. PMID: 20855612; PMCID: PMC2951427.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    101. Identification of a cell of origin for human prostate cancer. Science. 2010 Jul 30; 329(5991):568-71. Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON. PMID: 20671189; PMCID: PMC2917982.
      View in: PubMed   Mentions: 325     Fields:    Translation:HumansAnimalsCells
    102. Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells. Mol Oncol. 2010 Oct; 4(5):385-96. Goldstein AS, Stoyanova T, Witte ON. PMID: 20688584; PMCID: PMC2939195.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    103. Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14286-91. Koya RC, Mok S, Comin-Anduix B, Chodon T, Radu CG, Nishimura MI, Witte ON, Ribas A. PMID: 20624956; PMCID: PMC2922609.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    104. Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia. Blood. 2010 Oct 07; 116(14):2522-30. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. PMID: 20562326; PMCID: PMC2953887.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    105. Novel PET probes specific for deoxycytidine kinase. J Nucl Med. 2010 Jul; 51(7):1092-8. Shu CJ, Campbell DO, Lee JT, Tran AQ, Wengrod JC, Witte ON, Phelps ME, Satyamurthy N, Czernin J, Radu CG. PMID: 20554721; PMCID: PMC3119947.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    106. PET probes for distinct metabolic pathways have different cell specificities during immune responses in mice. J Clin Invest. 2010 Jun; 120(6):2005-15. Nair-Gill E, Wiltzius SM, Wei XX, Cheng D, Riedinger M, Radu CG, Witte ON. PMID: 20484820; PMCID: PMC2877561.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    107. Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. Prostate. 2010 Apr 01; 70(5):491-501. Garraway IP, Sun W, Tran CP, Perner S, Zhang B, Goldstein AS, Hahm SA, Haider M, Head CS, Reiter RE, Rubin MA, Witte ON. PMID: 19938015; PMCID: PMC2885946.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    108. Isolation, cultivation and characterization of adult murine prostate stem cells. Nat Protoc. 2010 Apr; 5(4):702-13. Lukacs RU, Goldstein AS, Lawson DA, Cheng D, Witte ON. PMID: 20360765; PMCID: PMC2943378.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    109. Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions. Lab Chip. 2010 May 07; 10(9):1113-9. Kamei K, Ohashi M, Gschweng E, Ho Q, Suh J, Tang J, For Yu ZT, Clark AT, Pyle AD, Teitell MA, Lee KB, Witte ON, Tseng HR. PMID: 20390128; PMCID: PMC2970622.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    110. Targeting leukemia stem cells. Nat Biotechnol. 2010 Mar; 28(3):237-8. Mikkola HK, Radu CG, Witte ON. PMID: 20212485.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    111. Visualizing cancer and immune cell function with metabolic positron emission tomography. Curr Opin Genet Dev. 2010 Feb; 20(1):100-5. Laing RE, Nair-Gill E, Witte ON, Radu CG. PMID: 19931447; PMCID: PMC3799818.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    112. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2610-5. Lawson DA, Zong Y, Memarzadeh S, Xin L, Huang J, Witte ON. PMID: 20133806; PMCID: PMC2823887.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    113. Epithelial uptake of [18F]1-(2'-deoxy-2'-arabinofuranosyl) cytosine indicates intestinal inflammation in mice. Gastroenterology. 2010 Apr; 138(4):1266-75. Brewer S, Nair-Gill E, Wei B, Chen L, Li X, Riedinger M, Campbell DO, Wiltzius S, Satyamurthy N, Phelps ME, Radu C, Witte ON, Braun J. PMID: 20080095; PMCID: PMC2846967.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    114. A seminal finding for prostate cancer? N Engl J Med. 2010 Jan 14; 362(2):175-6. Huang J, Witte ON. PMID: 20071710.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    115. Overcoming barriers to programming a therapeutic cellular immune response to fight melanoma. Pigment Cell Melanoma Res. 2010 Apr; 23(2):288-9. Baltimore D, Witte ON, Yang L, Economou J, Ribas A. PMID: 20067554.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    116. Requirement for deoxycytidine kinase in T and B lymphocyte development. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5551-6. Toy G, Austin WR, Liao HI, Cheng D, Singh A, Campbell DO, Ishikawa TO, Lehmann LW, Satyamurthy N, Phelps ME, Herschman HR, Czernin J, Witte ON, Radu CG. PMID: 20080663; PMCID: PMC2851816.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    117. Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res. 2009 Nov 15; 69(22):8555-62. Mulholland DJ, Xin L, Morim A, Lawson D, Witte O, Wu H. PMID: 19887604; PMCID: PMC2783355.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    118. Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood. 2009 Sep 24; 114(13):2774-82. Kottyan LC, Collier AR, Cao KH, Niese KA, Hedgebeth M, Radu CG, Witte ON, Khurana Hershey GK, Rothenberg ME, Zimmermann N. PMID: 19641187; PMCID: PMC2756132.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    119. Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells. J Am Chem Soc. 2009 Jul 22; 131(28):9695-703. Kwong GA, Radu CG, Hwang K, Shu CJ, Ma C, Koya RC, Comin-Anduix B, Hadrup SR, Bailey RC, Witte ON, Schumacher TN, Ribas A, Heath JR. PMID: 19552409; PMCID: PMC2720314.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    120. ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12465-70. Zong Y, Xin L, Goldstein AS, Lawson DA, Teitell MA, Witte ON. PMID: 19592505; PMCID: PMC2708977.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    121. Integrated microfluidic devices for combinatorial cell-based assays. Biomed Microdevices. 2009 Jun; 11(3):547-55. Yu ZT, Kamei K, Takahashi H, Shu CJ, Wang X, He GW, Silverman R, Radu CG, Witte ON, Lee KB, Tseng HR. PMID: 19130244; PMCID: PMC2893875.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    122. Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2847-52. Laing RE, Walter MA, Campbell DO, Herschman HR, Satyamurthy N, Phelps ME, Czernin J, Witte ON, Radu CG. PMID: 19196993; PMCID: PMC2636738.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    123. Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen. Int Immunol. 2009 Feb; 21(2):155-65. Shu CJ, Radu CG, Shelly SM, Vo DD, Prins R, Ribas A, Phelps ME, Witte ON. PMID: 19106231; PMCID: PMC2638874.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    124. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20882-7. Goldstein AS, Lawson DA, Cheng D, Sun W, Garraway IP, Witte ON. PMID: 19088204; PMCID: PMC2603432.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCells
    125. An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells. Lab Chip. 2009 Feb 21; 9(4):555-63. Kamei K, Guo S, Yu ZT, Takahashi H, Gschweng E, Suh C, Wang X, Tang J, McLaughlin J, Witte ON, Lee KB, Tseng HR. PMID: 19190791.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    126. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev. 2008 Nov 15; 22(22):3115-20. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. PMID: 19056891; PMCID: PMC2593609.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    127. Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14459-64. Valamehr B, Jonas SJ, Polleux J, Qiao R, Guo S, Gschweng EH, Stiles B, Kam K, Luo TJ, Witte ON, Liu X, Dunn B, Wu H. PMID: 18791068; PMCID: PMC2567159.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    128. Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog. Nat Med. 2008 Jul; 14(7):783-8. Radu CG, Shu CJ, Nair-Gill E, Shelly SM, Barrio JR, Satyamurthy N, Phelps ME, Witte ON. PMID: 18542051; PMCID: PMC2720060.
      View in: PubMed   Mentions: 113     Fields:    Translation:Animals
    129. Transforming growth factor-beta activation promotes genetic context-dependent invasion of immortalized melanocytes. Cancer Res. 2008 Jun 01; 68(11):4248-57. Lo RS, Witte ON. PMID: 18519684.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    130. Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain. Cancer Immunol Immunother. 2008 Sep; 57(9):1279-89. Prins RM, Shu CJ, Radu CG, Vo DD, Khan-Farooqi H, Soto H, Yang MY, Lin MS, Shelly S, Witte ON, Ribas A, Liau LM. PMID: 18253732; PMCID: PMC2614264.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    131. Non-invasive imaging of adaptive immunity using positron emission tomography. Immunol Rev. 2008 Feb; 221:214-28. Nair-Gill ED, Shu CJ, Radu CG, Witte ON. PMID: 18275485.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    132. Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation. Prostate. 2008 Feb 01; 68(2):139-51. Moore ML, Teitell MA, Kim Y, Watabe T, Reiter RE, Witte ON, Dubey P. PMID: 18044730.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    133. Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. J Biol Chem. 2008 Feb 29; 283(9):5296-305. Peter C, Waibel M, Radu CG, Yang LV, Witte ON, Schulze-Osthoff K, Wesselborg S, Lauber K. PMID: 18089568.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    134. Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20501-6. McLaughlin J, Cheng D, Singer O, Lukacs RU, Radu CG, Verma IM, Witte ON. PMID: 18079287; PMCID: PMC2154460.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    135. Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell. 2007 Dec; 12(6):572-85. Memarzadeh S, Xin L, Mulholland DJ, Mansukhani A, Wu H, Teitell MA, Witte ON. PMID: 18068633; PMCID: PMC2931420.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    136. Linking the hematopoietic microenvironment to imatinib-resistant Ph+ B-ALL. Genes Dev. 2007 Sep 15; 21(18):2249-52. Dorshkind K, Witte ON. PMID: 17875661.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    137. Stem cells in prostate cancer initiation and progression. J Clin Invest. 2007 Aug; 117(8):2044-50. Lawson DA, Witte ON. PMID: 17671638; PMCID: PMC1934594.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    138. Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells. 2007 Nov; 25(11):2760-9. Xin L, Lukacs RU, Lawson DA, Cheng D, Witte ON. PMID: 17641240.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    139. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood. 2007 Sep 15; 110(6):1831-9. Signer RA, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K. PMID: 17554060; PMCID: PMC1976345.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    140. DNA-encoded antibody libraries: a unified platform for multiplexed cell sorting and detection of genes and proteins. J Am Chem Soc. 2007 Feb 21; 129(7):1959-67. Bailey RC, Kwong GA, Radu CG, Witte ON, Heath JR. PMID: 17260987; PMCID: PMC3677962.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    141. Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1937-42. Radu CG, Shu CJ, Shelly SM, Phelps ME, Witte ON. PMID: 17261805; PMCID: PMC1783904.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    142. Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):181-6. Lawson DA, Xin L, Lukacs RU, Cheng D, Witte ON. PMID: 17185413; PMCID: PMC1716155.
      View in: PubMed   Mentions: 214     Fields:    Translation:AnimalsCells
    143. Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Mol Cell Biol. 2007 Feb; 27(4):1334-47. Yang LV, Radu CG, Roy M, Lee S, McLaughlin J, Teitell MA, Iruela-Arispe ML, Witte ON. PMID: 17145776; PMCID: PMC1800706.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    144. Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7789-94. Xin L, Teitell MA, Lawson DA, Kwon A, Mellinghoff IK, Witte ON. PMID: 16682621; PMCID: PMC1458510.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    145. NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell. 2006 May; 9(5):367-78. Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Gleave ME, Witte ON, Liu X, Wu H. PMID: 16697957.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    146. Induction of in vivo antipolysaccharide immunoglobulin responses to intact Streptococcus pneumoniae is more heavily dependent on Btk-mediated B-cell receptor signaling than antiprotein responses. Infect Immun. 2006 Feb; 74(2):1419-24. Khan AQ, Sen G, Guo S, Witte ON, Snapper CM. PMID: 16428797; PMCID: PMC1360338.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    147. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1480-5. Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H. PMID: 16432235; PMCID: PMC1345717.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    148. Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor. Mol Cell Biol. 2006 Jan; 26(2):668-77. Radu CG, Cheng D, Nijagal A, Riedinger M, McLaughlin J, Yang LV, Johnson J, Witte ON. PMID: 16382156; PMCID: PMC1346912.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    149. Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science. 2005 Dec 16; 310(5755):1793-6. Lee CC, Sui G, Elizarov A, Shu CJ, Shin YS, Dooley AN, Huang J, Daridon A, Wyatt P, Stout D, Kolb HC, Witte ON, Satyamurthy N, Heath JR, Phelps ME, Quake SR, Tseng HR. PMID: 16357255.
      View in: PubMed   Mentions: 90     Fields:    Translation:Animals
    150. Visualization of a primary anti-tumor immune response by positron emission tomography. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17412-7. Shu CJ, Guo S, Kim YJ, Shelly SM, Nijagal A, Ray P, Gambhir SS, Radu CG, Witte ON. PMID: 16293690; PMCID: PMC1283986.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    151. Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families. Int Immunol. 2006 Jan; 18(1):79-87. Guo S, Wahl MI, Witte ON. PMID: 16291652.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    152. UCLA director gets the goods as California makes good on its stem cell initiative. Interview by Stacie Bloom. J Clin Invest. 2005 Nov; 115(11):2958. Witte O. PMID: 16276406; PMCID: PMC1265884.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    153. The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6942-7. Xin L, Lawson DA, Witte ON. PMID: 15860580; PMCID: PMC1087514.
      View in: PubMed   Mentions: 199     Fields:    Translation:AnimalsCells
    154. Unraveling kinase signaling pathways with chemical genetic and chemical proteomic approaches. Cell Cycle. 2005 Mar; 4(3):434-7. Beillard E, Witte ON. PMID: 15711120.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    155. Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A. Mol Biol Cell. 2005 May; 16(5):2234-47. Wang L, Radu CG, Yang LV, Bentolila LA, Riedinger M, Witte ON. PMID: 15728718; PMCID: PMC1087231.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    156. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1632-7. Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON. PMID: 15665078; PMCID: PMC545089.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    157. Retraction. Science. 2005 Jan 14; 307(5707):206. Witte ON, Kabarowski JH, Xu Y, Le LQ, Zhu K. PMID: 15653487.
      View in: PubMed   Mentions: 25     Fields:    
    158. Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. Blood. 2005 Feb 01; 105(3):1127-34. Yang LV, Radu CG, Wang L, Riedinger M, Witte ON. PMID: 15383458.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    159. A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14180-5. Guo S, Ferl GZ, Deora R, Riedinger M, Yin S, Kerwin JL, Loo JA, Witte ON. PMID: 15375214; PMCID: PMC521099.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    160. Multimodality imaging of lymphocytic migration using lentiviral-based transduction of a tri-fusion reporter gene. Mol Imaging Biol. 2004 Sep-Oct; 6(5):331-40. Kim YJ, Dubey P, Ray P, Gambhir SS, Witte ON. PMID: 15380743.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    161. Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Blood. 2004 Sep 01; 104(5):1281-90. Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ. PMID: 15142874.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    162. Got MLL? Definitive hematopoiesis requires MLL gene expression. Mol Cell. 2004 Mar 26; 13(6):765-6. Dorshkind K, Witte O. PMID: 15053868.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    163. Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. Blood. 2004 Jun 01; 103(11):4268-75. Kharas MG, Deane JA, Wong S, O'Bosky KR, Rosenberg N, Witte ON, Fruman DA. PMID: 14976048.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    164. The BCR-ABL story: bench to bedside and back. Annu Rev Immunol. 2004; 22:247-306. Wong S, Witte ON. PMID: 15032571.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimals
    165. T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):245-50. Radu CG, Yang LV, Riedinger M, Au M, Witte ON. PMID: 14681556; PMCID: PMC314170.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    166. IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11630-5. Wong S, McLaughlin J, Cheng D, Shannon K, Robb L, Witte ON. PMID: 14500898; PMCID: PMC208809.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    167. Extending the utility of gene profiling data by bridging microarray platforms. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10585-7. Ferl GZ, Timmerman JM, Witte ON. PMID: 12963810; PMCID: PMC196845.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    168. Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice. J Immunol. 2003 Aug 15; 171(4):1850-8. Whyburn LR, Halcomb KE, Contreras CM, Lowell CA, Witte ON, Satterthwaite AB. PMID: 12902486.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    169. In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11896-903. Xin L, Ide H, Kim Y, Dubey P, Witte ON. PMID: 12909713; PMCID: PMC304104.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    170. Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton's tyrosine kinase. Int Immunol. 2003 Mar; 15(3):383-92. Whyburn LR, Halcomb KE, Contreras CM, Pappu R, Witte ON, Chan AC, Satterthwaite AB. PMID: 12618482.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    171. Quantitative imaging of the T cell antitumor response by positron-emission tomography. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1232-7. Dubey P, Su H, Adonai N, Du S, Rosato A, Braun J, Gambhir SS, Witte ON. PMID: 12547911; PMCID: PMC298756.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    172. Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors. Blood. 2003 May 15; 101(10):4088-97. Wong S, McLaughlin J, Cheng D, Witte ON. PMID: 12521991.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    173. Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14404-9. Ide H, Seligson DB, Memarzadeh S, Xin L, Horvath S, Dubey P, Flick MB, Kacinski BM, Palotie A, Witte ON. PMID: 12381783; PMCID: PMC137896.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    174. Lysophosphatidylcholine as a ligand for immunoregulation. Biochem Pharmacol. 2002 Jul 15; 64(2):161-7. Kabarowski JH, Xu Y, Witte ON. PMID: 12123735.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    175. Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction. J Immunol. 2002 Jun 01; 168(11):5465-76. Fujimoto M, Poe JC, Satterthwaite AB, Wahl MI, Witte ON, Tedder TF. PMID: 12023340.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    176. Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene. Cancer Cell. 2002 May; 1(4):381-91. Le LQ, Kabarowski JH, Wong S, Nguyen K, Gambhir SS, Witte ON. PMID: 12086852.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    177. Recognition of multiple substrate motifs by the c-ABL protein tyrosine kinase. Comb Chem High Throughput Screen. 2002 Feb; 5(1):83-91. Wu JJ, Afar DE, Phan H, Witte ON, Lam KS. PMID: 11860343.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    178. Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):359-64. Fruman DA, Ferl GZ, An SS, Donahue AC, Satterthwaite AB, Witte ON. PMID: 11756681; PMCID: PMC117565.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    179. Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):401-6. Watabe T, Lin M, Ide H, Donjacour AA, Cunha GR, Witte ON, Reiter RE. PMID: 11752398; PMCID: PMC117572.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
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