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Owen N Witte

Title(s)Professor, MIMG
SchoolMedicine
Address609 Charles E. Young Drive, Ea 1602A
Los Angeles CA 90024
Phone66411,60386
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    Other Positions
    Title(s)Professor, Molecular and Medical Pharmacology


    Collapse Research 
    Collapse Research Activities and Funding
    Targeting alternative splicing for TCR discovery in small cell carcinomas
    NIH/NCI U01CA233074Sep 21, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Targeting Genomic Instability in Lethal Neuroendocrine Prostate Cancer
    NIH/NCI R01CA222877Jun 6, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Multi-omic analysis of Myc-driven splicing for prostate cancer therapeutic development
    NIH/NCI R01CA220238Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Influences of the Microenvironment on Cancer Stem Cells
    NIH/NCI U01CA164188Sep 15, 2011 - Aug 31, 2016
    Role: Principal Investigator
    ABL ONCOGENE AND MURINE AND HUMAN LEUKEMIAS
    NIH/NCI R01CA076204Mar 1, 1998 - Feb 28, 2004
    Role: Principal Investigator
    ROLE OF THE ABL ONCOGENE IN MURINE &HUMAN LEUKEMIAS
    NIH/NCI R35CA053867May 15, 1991 - Feb 28, 1998
    Role: Principal Investigator
    MOLECULAR DIAGNOSIS OF CHRONIC MYELOGENOUS LEUKEMIA
    NIH/NCI R01CA040957Sep 1, 1985 - Feb 28, 1989
    Role: Principal Investigator
    UCLA-Caltech Medical Scientist Training Program
    NIH/NIGMS T32GM008042Jul 1, 1983 - Jun 30, 2024
    Role: Co-Principal Investigator
    Tumor Cell Biology Training Program
    NIH/NCI T32CA009056Jul 1, 1980 - Mar 31, 2001
    Role: Co-Principal Investigator
    TRANSFORMATION BY ABELSON MURINE LEUKEMIA VIRUS
    NIH/NCI R01CA027507May 1, 1980 - Apr 30, 1991
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting RET Kinase in Neuroendocrine Prostate Cancer. Mol Cancer Res. 2020 Aug; 18(8):1176-1188. VanDeusen HR, Ramroop JR, Morel KL, Bae SY, Sheahan AV, Sychev Z, Lau NA, Cheng LC, Tan VM, Li Z, Petersen A, Lee JK, Park JW, Yang R, Hwang JH, Coleman I, Witte ON, Morrissey C, Corey E, Nelson PS, Ellis L, Drake JM. PMID: 32461304.
      View in: PubMed   Mentions:    Fields:    
    2. Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance. Proc Natl Acad Sci U S A. 2020 Jun 02; 117(22):12315-12323. Alumkal JJ, Sun D, Lu E, Beer TM, Thomas GV, Latour E, Aggarwal R, Cetnar J, Ryan CJ, Tabatabaei S, Bailey S, Turina CB, Quigley DA, Guan X, Foye A, Youngren JF, Urrutia J, Huang J, Weinstein AS, Friedl V, Rettig M, Reiter RE, Spratt DE, Gleave M, Evans CP, Stuart JM, Chen Y, Feng FY, Small EJ, Witte ON, Xia Z. PMID: 32424106.
      View in: PubMed   Mentions: 1     Fields:    
    3. Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5269-5279. Phillips JW, Pan Y, Tsai BL, Xie Z, Demirdjian L, Xiao W, Yang HT, Zhang Y, Lin CH, Cheng D, Hu Q, Liu S, Black DL, Witte ON, Xing Y. PMID: 32086391.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):563-572. Wang L, Smith BA, Balanis NG, Tsai BL, Nguyen K, Cheng MW, Obusan MB, Esedebe FN, Patel SJ, Zhang H, Clark PM, Sisk AE, Said JW, Huang J, Graeber TG, Witte ON, Chin AI, Park JW. PMID: 31871155.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. Sci Transl Med. 2019 12 04; 11(521). Li Y, He Y, Butler W, Xu L, Chang Y, Lei K, Zhang H, Zhou Y, Gao AC, Zhang Q, Taylor DG, Cheng D, Farber-Katz S, Karam R, Landrith T, Li B, Wu S, Hsuan V, Yang Q, Hu H, Chen X, Flowers M, McCall SJ, Lee JK, Smith BA, Park JW, Goldstein AS, Witte ON, Wang Q, Rettig MB, Armstrong AJ, Cheng Q, Huang J. PMID: 31801883.
      View in: PubMed   Mentions: 1     Fields:    
    6. 18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis. J Nucl Med. 2020 May; 61(5):757-763. Chen BY, Ghezzi C, Villegas B, Quon A, Radu CG, Witte ON, Clark PM. PMID: 31653711.
      View in: PubMed   Mentions:    Fields:    
    7. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. 2019 10 03; 25(4):542-557.e9. Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, McLaughlin J, Cheng D, Hollis RP, Campo-Fernandez B, Urbinati F, Wei L, Pang L, Rezek V, Berent-Maoz B, Macabali MH, Gjertson D, Wang X, Galic Z, Kitchen SG, An DS, Hu-Lieskovan S, Kaplan-Lefko PJ, De Oliveira SN, Seet CS, Larson SM, Forman SJ, Heath JR, Zack JA, Crooks GM, Radu CG, Ribas A, Kohn DB, Witte ON, Yang L. PMID: 31495780.
      View in: PubMed   Mentions: 1     Fields:    
    8. Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood. Cell Rep. 2019 09 03; 28(10):2728-2738.e7. Peng S, Zaretsky JM, Ng AHC, Chour W, Bethune MT, Choi J, Hsu A, Holman E, Ding X, Guo K, Kim J, Xu AM, Heath JE, Noh WJ, Zhou J, Su Y, Lu Y, McLaughlin J, Cheng D, Witte ON, Baltimore D, Ribas A, Heath JR. PMID: 31484081.
      View in: PubMed   Mentions: 5     Fields:    
    9. Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies. Cancer Cell. 2019 07 08; 36(1):17-34.e7. Balanis NG, Sheu KM, Esedebe FN, Patel SJ, Smith BA, Park JW, Alhani S, Gomperts BN, Huang J, Witte ON, Graeber TG. PMID: 31287989.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer. Prostate Cancer Prostatic Dis. 2019 12; 22(4):531-538. Nickols NG, Nazarian R, Zhao SG, Tan V, Uzunangelov V, Xia Z, Baertsch R, Neeman E, Gao AC, Thomas GV, Howard L, De Hoedt AM, Stuart J, Goldstein T, Chi K, Gleave ME, Graff JN, Beer TM, Drake JM, Evans CP, Aggarwal R, Foye A, Feng FY, Small EJ, Aronson WJ, Freedland SJ, Witte ON, Huang J, Alumkal JJ, Reiter RE, Rettig MB. PMID: 30804427.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. T cell antigen discovery via trogocytosis. Nat Methods. 2019 02; 16(2):183-190. Li G, Bethune MT, Wong S, Joglekar AV, Leonard MT, Wang JK, Kim JT, Cheng D, Peng S, Zaretsky JM, Su Y, Luo Y, Heath JR, Ribas A, Witte ON, Baltimore D. PMID: 30700903.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System. Clin Cancer Res. 2019 02 01; 25(3):1000-1011. Puig-Saus C, Parisi G, Garcia-Diaz A, Krystofinski PE, Sandoval S, Zhang R, Champhekar AS, McCabe J, Cheung-Lau GC, Truong NA, Vega-Crespo A, Komenan MDS, Pang J, Macabali MH, Saco JD, Goodwin JL, Bolon B, Seet CS, Montel-Hagen A, Crooks GM, Hollis RP, Campo-Fernandez B, Bischof D, Cornetta K, Gschweng EH, Adelson C, Nguyen A, Yang L, Witte ON, Baltimore D, Comin-Anduix B, Kohn DB, Wang X, Cabrera P, Kaplan-Lefko PJ, Berent-Maoz B, Ribas A. PMID: 30409823.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    13. Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10702-E10711. Bethune MT, Li XH, Yu J, McLaughlin J, Cheng D, Mathis C, Moreno BH, Woods K, Knights AJ, Garcia-Diaz A, Wong S, Hu-Lieskovan S, Puig-Saus C, Cebon J, Ribas A, Yang L, Witte ON, Baltimore D. PMID: 30348802.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    14. Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Science. 2018 10 05; 362(6410):91-95. Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON. PMID: 30287662.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    15. A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers. Cell Rep. 2018 09 18; 24(12):3353-3366.e5. Smith BA, Balanis NG, Nanjundiah A, Sheu KM, Tsai BL, Zhang Q, Park JW, Thompson M, Huang J, Witte ON, Graeber TG. PMID: 30232014.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 2018 07 26; 174(3):758-769.e9. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY. PMID: 30033370.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    17. Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study. J Clin Oncol. 2018 08 20; 36(24):2492-2503. Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, Rettig M, Wong CK, True L, Foye A, Playdle D, Ryan CJ, Lara P, Chi KN, Uzunangelov V, Sokolov A, Newton Y, Beltran H, Demichelis F, Rubin MA, Stuart JM, Small EJ. PMID: 29985747.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCellsCTClinical Trials
    18. 18F-FAC PET Selectively Images Liver-Infiltrating CD4 and CD8 T Cells in a Mouse Model of Autoimmune Hepatitis. J Nucl Med. 2018 10; 59(10):1616-1623. Salas JR, Chen BY, Wong A, Cheng D, Van Arnam JS, Witte ON, Clark PM. PMID: 29700125.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    19. Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Proc Natl Acad Sci U S A. 2018 05 08; 115(19):E4473-E4482. Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON. PMID: 29686080.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Noninvasive Imaging of Drug-Induced Liver Injury with 18F-DFA PET. J Nucl Med. 2018 08; 59(8):1308-1315. Salas JR, Chen BY, Wong A, Duarte S, Angarita SAK, Lipshutz GS, Witte ON, Clark PM. PMID: 29496991.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate. Mod Pathol. 2017 09; 30(9):1262-1272. Park JW, Lee JK, Witte ON, Huang J. PMID: 28621319.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    22. Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL. J Exp Med. 2017 03 06; 214(3):793-814. Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M. PMID: 28190001.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    23. Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome. Cell Rep. 2016 12 06; 17(10):2596-2606. Liu X, Grogan TR, Hieronymus H, Hashimoto T, Mottahedeh J, Cheng D, Zhang L, Huang K, Stoyanova T, Park JW, Shkhyan RO, Nowroozizadeh B, Rettig MB, Sawyers CL, Elashoff D, Horvath S, Huang J, Witte ON, Goldstein AS. PMID: 27926864.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    24. Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer: Update on the Stand Up 2 Cancer/Prostate Cancer Foundation-Supported West Coast Prostate Cancer Dream Team. Eur Urol Focus. 2016 Dec; 2(5):469-471. Aggarwal R, Beer TM, Gleave M, Stuart JM, Rettig M, Evans CP, Youngren J, Alumkal JJ, Huang J, Thomas G, Witte O, Small EJ. PMID: 28723508.
      View in: PubMed   Mentions: 4     Fields:    
    25. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6457-E6466. Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter RE, Pitteri SJ, Huang J, Witte ON. PMID: 27694579.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    26. Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell. 2016 Aug 11; 166(4):1041-1054. Drake JM, Paull EO, Graham NA, Lee JK, Smith BA, Titz B, Stoyanova T, Faltermeier CM, Uzunangelov V, Carlin DE, Fleming DT, Wong CK, Newton Y, Sudha S, Vashisht AA, Huang J, Wohlschlegel JA, Graeber TG, Witte ON, Stuart JM. PMID: 27499020.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    27. Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4482-7. Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON. PMID: 27044116.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    28. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 2016 Apr 11; 29(4):536-547. Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON. PMID: 27050099.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    29. [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4027-32. Kim W, Le TM, Wei L, Poddar S, Bazzy J, Wang X, Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D, Gipson RM, Slavik R, Cabebe AE, Taechariyakul T, Yaghoubi SS, Lee JT, Sadeghi S, Lavie A, Faull KF, Witte ON, Donahue TR, Phelps ME, Herschman HR, Herrmann K, Czernin J, Radu CG. PMID: 27035974.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Tissue Recombination Models for the Study of Epithelial Cancer. Cold Spring Harb Protoc. 2015 Dec 02; 2015(12):pdb.top069880. Zong Y, Goldstein AS, Witte ON. PMID: 26631129.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):E172-81. Faltermeier CM, Drake JM, Clark PM, Smith BA, Zong Y, Volpe C, Mathis C, Morrissey C, Castor B, Huang J, Witte ON. PMID: 26621741.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    32. An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy. Cancer Res. 2016 Jan 01; 76(1):73-82. Tavaré R, Escuin-Ordinas H, Mok S, McCracken MN, Zettlitz KA, Salazar FB, Witte ON, Ribas A, Wu AM. PMID: 26573799.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    33. Lift NIH restrictions on chimera research. Science. 2015 Nov 06; 350(6261):640. Sharma A, Sebastiano V, Scott CT, Magnus D, Koyano-Nakagawa N, Garry DJ, Witte ON, Nakauchi H, Wu JC, Weissman IL, Wu SM. PMID: 26542560.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    34. Preparation of Urogenital Sinus Mesenchymal Cells for Prostate Tissue Recombination Models. Cold Spring Harb Protoc. 2015 Nov 02; 2015(11):988-90. Zong Y, Goldstein AS, Witte ON. PMID: 26527759.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    35. Dissociated Prostate Regeneration under the Renal Capsule. Cold Spring Harb Protoc. 2015 Nov 02; 2015(11):991-4. Zong Y, Goldstein AS, Witte ON. PMID: 26527760.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    36. A basal stem cell signature identifies aggressive prostate cancer phenotypes. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6544-52. Smith BA, Sokolov A, Uzunangelov V, Baertsch R, Newton Y, Graim K, Mathis C, Cheng D, Stuart JM, Witte ON. PMID: 26460041.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    37. DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis. Cancer Cell. 2015 Jul 13; 28(1):97-113. Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes RJ, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE. PMID: 26175416.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    38. Development of 2-Deoxy-2-[(18)F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo. J Med Chem. 2015 Jul 23; 58(14):5538-47. Evdokimov NM, Clark PM, Flores G, Chai T, Faull KF, Phelps ME, Witte ON, Jung ME. PMID: 26102222.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    39. Immuno-PET of Murine T Cell Reconstitution Postadoptive Stem Cell Transplantation Using Anti-CD4 and Anti-CD8 Cys-Diabodies. J Nucl Med. 2015 Aug; 56(8):1258-64. Tavaré R, McCracken MN, Zettlitz KA, Salazar FB, Olafsen T, Witte ON, Wu AM. PMID: 25952734.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    40. Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging. J Clin Invest. 2015 May; 125(5):1815-26. McCracken MN, Vatakis DN, Dixit D, McLaughlin J, Zack JA, Witte ON. PMID: 25822024.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    41. Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1523-8. Smith DJ, Liu S, Ji S, Li B, McLaughlin J, Cheng D, Witte ON, Yang L. PMID: 25605948.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    42. Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. PLoS One. 2014; 9(8):e104125. Bunimovich YL, Nair-Gill E, Riedinger M, McCracken MN, Cheng D, McLaughlin J, Radu CG, Witte ON. PMID: 25101980.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    43. HSV-sr39TK positron emission tomography and suicide gene elimination of human hematopoietic stem cells and their progeny in humanized mice. Cancer Res. 2014 Sep 15; 74(18):5173-83. Gschweng EH, McCracken MN, Kaufman ML, Ho M, Hollis RP, Wang X, Saini N, Koya RC, Chodon T, Ribas A, Witte ON, Kohn DB. PMID: 25038231.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    44. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):E2866-74. Clark PM, Flores G, Evdokimov NM, McCracken MN, Chai T, Nair-Gill E, O'Mahony F, Beaven SW, Faull KF, Phelps ME, Jung ME, Witte ON. PMID: 24982199.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    45. Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clin Cancer Res. 2014 May 01; 20(9):2457-65. Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, Gjertson DW, Cochran AJ, Cornetta K, Wong DJ, Kaplan-Lefko P, Hamid O, Samlowski W, Cohen PA, Daniels GA, Mukherji B, Yang L, Zack JA, Kohn DB, Heath JR, Glaspy JA, Witte ON, Baltimore D, Economou JS, Ribas A. PMID: 24634374.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    46. Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer. Mol Cell Biol. 2014 May; 34(10):1722-32. Drake JM, Lee JK, Witte ON. PMID: 24567371.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    47. Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1108-13. Tavaré R, McCracken MN, Zettlitz KA, Knowles SM, Salazar FB, Olafsen T, Witte ON, Wu AM. PMID: 24390540.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    48. Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20111-6. Stoyanova T, Cooper AR, Drake JM, Liu X, Armstrong AJ, Pienta KJ, Zhang H, Kohn DB, Huang J, Witte ON, Goldstein AS. PMID: 24282295.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    49. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):E4762-9. Drake JM, Graham NA, Lee JK, Stoyanova T, Faltermeier CM, Sud S, Titz B, Huang J, Pienta KJ, Graeber TG, Witte ON. PMID: 24248375.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    50. Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo. Mol Cancer Ther. 2013 Dec; 12(12):2917-28. Janzen DM, Paik DY, Rosales MA, Yep B, Cheng D, Witte ON, Kayadibi H, Ryan CM, Jung ME, Faull K, Memarzadeh S. PMID: 24222661.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
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    127. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1632-7. Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON. PMID: 15665078.
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    129. A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14180-5. Guo S, Ferl GZ, Deora R, Riedinger M, Yin S, Kerwin JL, Loo JA, Witte ON. PMID: 15375214.
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    135. IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11630-5. Wong S, McLaughlin J, Cheng D, Shannon K, Robb L, Witte ON. PMID: 14500898.
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    136. Extending the utility of gene profiling data by bridging microarray platforms. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10585-7. Ferl GZ, Timmerman JM, Witte ON. PMID: 12963810.
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    137. In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11896-903. Xin L, Ide H, Kim Y, Dubey P, Witte ON. PMID: 12909713.
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    138. Quantitative imaging of the T cell antitumor response by positron-emission tomography. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1232-7. Dubey P, Su H, Adonai N, Du S, Rosato A, Braun J, Gambhir SS, Witte ON. PMID: 12547911.
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    139. Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors. Blood. 2003 May 15; 101(10):4088-97. Wong S, McLaughlin J, Cheng D, Witte ON. PMID: 12521991.
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    140. Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14404-9. Ide H, Seligson DB, Memarzadeh S, Xin L, Horvath S, Dubey P, Flick MB, Kacinski BM, Palotie A, Witte ON. PMID: 12381783.
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    141. Lysophosphatidylcholine as a ligand for immunoregulation. Biochem Pharmacol. 2002 Jul 15; 64(2):161-7. Kabarowski JH, Xu Y, Witte ON. PMID: 12123735.
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    142. Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene. Cancer Cell. 2002 May; 1(4):381-91. Le LQ, Kabarowski JH, Wong S, Nguyen K, Gambhir SS, Witte ON. PMID: 12086852.
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    143. Recognition of multiple substrate motifs by the c-ABL protein tyrosine kinase. Comb Chem High Throughput Screen. 2002 Feb; 5(1):83-91. Wu JJ, Afar DE, Phan H, Witte ON, Lam KS. PMID: 11860343.
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    144. Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):401-6. Watabe T, Lin M, Ide H, Donjacour AA, Cunha GR, Witte ON, Reiter RE. PMID: 11752398.
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