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Gomperts, Brigitte N

Title(s)Professor, Pediatrics
SchoolPed - Hematology And Oncology
Phone56708
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    Other Positions
    Title(s)Professor, Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    Developing a targeted chemoprevention strategy for Non-Small Cell Lung Cancer
    NIH/NCI R01CA208303Aug 15, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Development of a High-Throughput Screen for Pre-therapeutic Discovery in Idiopathic Pulmonary Fibrosis
    NIH/NIGMS R01GM114259Mar 1, 2015 - Feb 28, 2018
    Role: Principal Investigator
    Progenitor Cells in Airway Repair
    NIH/NHLBI R01HL094561Sep 1, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Cytokine Regulation of the Pulmonary Epithelium
    NIH/NHLBI K08HL074229Dec 15, 2004 - Nov 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Aros CJ, Paul MK, Pantoja CJ, Bisht B, Meneses LK, Vijayaraj P, Sandlin JM, France B, Tse JA, Chen MW, Shia DW, Rickabaugh TM, Damoiseaux R, Gomperts BN. High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis. Cell Rep. 2020 Feb 18; 30(7):2055-2064.e5. PMID: 32075752.
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    2. Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros CJ, Ahadome SD, Shia DW, Chung K, Sandlin JM, Darmawan KF, Bhatt KV, Manze CC, Paul MK, Wilkinson DC, Yan W, Clark AT, Rickabaugh TM, Wallace WD, Graeber TG, Damoiseaux R, Gomperts BN. Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Cell Rep. 2019 Dec 10; 29(11):3488-3505.e9. PMID: 31825831.
      View in: PubMed
    3. Balanis NG, Sheu KM, Esedebe FN, Patel SJ, Smith BA, Park JW, Alhani S, Gomperts BN, Huang J, Witte ON, Graeber TG. Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies. Cancer Cell. 2019 Jul 08; 36(1):17-34.e7. PMID: 31287989.
      View in: PubMed
    4. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. Correction to: Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2019 Feb 12; 10(1):52. PMID: 30755264.
      View in: PubMed
    5. Wilkinson DC, Mellody M, Meneses LK, Hope AC, Dunn B, Gomperts BN. Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling. Curr Protoc Stem Cell Biol. 2018 08; 46(1):e56. PMID: 29927098.
      View in: PubMed
    6. Walser TC, Jing Z, Tran LM, Lin YQ, Yakobian N, Wang G, Krysan K, Zhu LX, Sharma S, Lee MH, Belperio JA, Ooi AT, Gomperts BN, Shay JW, Larsen JE, Minna JD, Hong LS, Fishbein MC, Dubinett SM. Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells. Cancer Res. 2018 04 15; 78(8):1986-1999. PMID: 29431637.
      View in: PubMed
    7. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2017 10 02; 8(1):217. PMID: 28969679.
      View in: PubMed
    8. Vijayaraj P, Gomperts BN. The aCCR(2)ual of M2 Macrophages Provides Some Breathing Room. Cell Stem Cell. 2017 07 06; 21(1):1-3. PMID: 28686859.
      View in: PubMed
    9. Wilkinson DC, Alva-Ornelas JA, Sucre JM, Vijayaraj P, Durra A, Richardson W, Jonas SJ, Paul MK, Karumbayaram S, Dunn B, Gomperts BN. Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling. Stem Cells Transl Med. 2017 02; 6(2):622-633. PMID: 28191779.
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    10. Sucre JM, Wilkinson D, Vijayaraj P, Paul M, Dunn B, Alva-Ornelas JA, Gomperts BN. A three-dimensional human model of the fibroblast activation that accompanies bronchopulmonary dysplasia identifies Notch-mediated pathophysiology. Am J Physiol Lung Cell Mol Physiol. 2016 05 15; 310(10):L889-98. PMID: 26968771.
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    11. Ooi AT, Gomperts BN. Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA. Clin Cancer Res. 2015 Jun 01; 21(11):2440-4. PMID: 25838393.
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    12. Paul MK, Bisht B, Darmawan DO, Chiou R, Ha VL, Wallace WD, Chon AT, Hegab AE, Grogan T, Elashoff DA, Alva-Ornelas JA, Gomperts BN. Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling. Cell Stem Cell. 2014 Aug 07; 15(2):199-214. PMID: 24953182.
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    13. Gomperts BN. Induction of multiciliated cells from induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):6120-1. PMID: 24740182.
      View in: PubMed
    14. Ooi AT, Gower AC, Zhang KX, Vick JL, Hong L, Nagao B, Wallace WD, Elashoff DA, Walser TC, Dubinett SM, Pellegrini M, Lenburg ME, Spira A, Gomperts BN. Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. Cancer Prev Res (Phila). 2014 May; 7(5):487-95. PMID: 24618292.
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    15. Hegab AE, Ha VL, Bisht B, Darmawan DO, Ooi AT, Zhang KX, Paul MK, Kim YS, Gilbert JL, Attiga YS, Alva-Ornelas JA, Nickerson DW, Gomperts BN. Aldehyde dehydrogenase activity enriches for proximal airway basal stem cells and promotes their proliferation. Stem Cells Dev. 2014 Mar 15; 23(6):664-75. PMID: 24171691.
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    16. Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18946-51. PMID: 24158479.
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    17. Gomperts BN, Walser TC, Spira A, Dubinett SM. Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer. Cancer Prev Res (Phila). 2013 Jan; 6(1):4-7. PMID: 23233734.
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    18. Hegab AE, Nickerson DW, Ha VL, Darmawan DO, Gomperts BN. Repair and regeneration of tracheal surface epithelium and submucosal glands in a mouse model of hypoxic-ischemic injury. Respirology. 2012 Oct; 17(7):1101-13. PMID: 22617027.
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    19. Hegab AE, Ha VL, Darmawan DO, Gilbert JL, Ooi AT, Attiga YS, Bisht B, Nickerson DW, Gomperts BN. Isolation and in vitro characterization of basal and submucosal gland duct stem/progenitor cells from human proximal airways. Stem Cells Transl Med. 2012 Oct; 1(10):719-24. PMID: 23197663.
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    20. Hegab AE, Ha VL, Attiga YS, Nickerson DW, Gomperts BN. Isolation of basal cells and submucosal gland duct cells from mouse trachea. J Vis Exp. 2012 Sep 14; (67):e3731. PMID: 23007468.
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    21. Ooi AT, Ram S, Kuo A, Gilbert JL, Yan W, Pellegrini M, Nickerson DW, Chatila TA, Gomperts BN. Identification of an interleukin 13-induced epigenetic signature in allergic airway inflammation. Am J Transl Res. 2012; 4(2):219-28. PMID: 22611474.
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    22. Hegab AE, Ha VL, Gilbert JL, Zhang KX, Malkoski SP, Chon AT, Darmawan DO, Bisht B, Ooi AT, Pellegrini M, Nickerson DW, Gomperts BN. Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential. Stem Cells. 2011 Aug; 29(8):1283-93. PMID: 21710468.
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    23. Gomperts BN, Spira A, Massion PP, Walser TC, Wistuba II, Minna JD, Dubinett SM. Evolving concepts in lung carcinogenesis. Semin Respir Crit Care Med. 2011 Feb; 32(1):32-43. PMID: 21500122.
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    24. Chang VY, Quintero-Rivera F, Baldwin EE, Woo K, Martinez-Agosto JA, Fu C, Gomperts BN. B-acute lymphoblastic leukemia and cystinuria in a patient with duplication 22q11.21 detected by chromosomal microarray analysis. Pediatr Blood Cancer. 2011 Mar; 56(3):470-3. PMID: 21225931.
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    25. Ooi AT, Mah V, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh EL, Chia D, Gower AC, Lenburg ME, Spira A, Solis LM, Wistuba II, Walser TC, Wallace WD, Dubinett SM, Goodglick L, Gomperts BN. Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer. Cancer Res. 2010 Aug 15; 70(16):6639-48. PMID: 20710044.
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    26. Gomperts BN, Spira A, Elashoff DE, Dubinett SM. Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection. Cancer Prev Res (Phila). 2010 Apr; 3(4):420-3. PMID: 20332300.
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    27. Nickerson DW, Presson AP, Weigt SS, Gregson AL, Belperio JA, Gomperts BN. Quantification of cytokeratin 5 mRNA expression in the circulation of healthy human subjects and after lung transplantation. PLoS One. 2009 Jun 16; 4(6):e5925. PMID: 19529775.
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    28. Bekmezian A, Gomperts B, Weisleder P, Patraitis C, Thibodeau P, Parker-Mello K. Index of suspicion. Pediatr Rev. 2009 Jan; 30(1):15-21. PMID: 19118138.
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    29. Bekmezian A, Gomperts B. Case 1: A limping child...with abdominal pain. Paediatr Child Health. 2008 Nov; 13(9):775-7. PMID: 19436540.
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    30. Mehrad B, Keane MP, Gomperts BN, Strieter RM. Circulating progenitor cells in chronic lung disease. Expert Rev Respir Med. 2007 Aug; 1(1):157-65. PMID: 20477275.
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    31. Gomperts BN, Strieter RM. Fibrocytes in lung disease. J Leukoc Biol. 2007 Sep; 82(3):449-56. PMID: 17550974.
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    32. Gomperts BN, Kim LJ, Flaherty SA, Hackett BP. IL-13 regulates cilia loss and foxj1 expression in human airway epithelium. Am J Respir Cell Mol Biol. 2007 Sep; 37(3):339-46. PMID: 17541011.
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    33. Gomperts BN, Belperio JA, Fishbein MC, Keane MP, Burdick MD, Strieter RM. Keratinocyte growth factor improves repair in the injured tracheal epithelium. Am J Respir Cell Mol Biol. 2007 Jul; 37(1):48-56. PMID: 17332441.
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    34. Strieter RM, Gomperts BN, Keane MP. The role of CXC chemokines in pulmonary fibrosis. J Clin Invest. 2007 Mar; 117(3):549-56. PMID: 17332882.
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    35. Gomperts BN, Strieter RM. Stem cells and chronic lung disease. Annu Rev Med. 2007; 58:285-98. PMID: 16886904.
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    36. Keane MP, Gomperts BN, Weigt S, Xue YY, Burdick MD, Nakamura H, Zisman DA, Ardehali A, Saggar R, Lynch JP, Hogaboam C, Kunkel SL, Lukacs NW, Ross DJ, Grusby MJ, Strieter RM, Belperio JA. IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. J Immunol. 2007 Jan 01; 178(1):511-9. PMID: 17182591.
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    37. Strieter RM, Burdick MD, Mestas J, Gomperts B, Keane MP, Belperio JA. Cancer CXC chemokine networks and tumour angiogenesis. Eur J Cancer. 2006 Apr; 42(6):768-78. PMID: 16510280.
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    38. Gomperts BN, Belperio JA, Rao PN, Randell SH, Fishbein MC, Burdick MD, Strieter RM. Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury. J Immunol. 2006 Feb 01; 176(3):1916-27. PMID: 16424223.
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    39. Gomperts BN, Strieter RM. Chemokine-directed metastasis. Contrib Microbiol. 2006; 13:170-190. PMID: 16627965.
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    40. Belperio JA, Keane MP, Burdick MD, Gomperts BN, Xue YY, Hong K, Mestas J, Zisman D, Ardehali A, Saggar R, Lynch JP, Ross DJ, Strieter RM. CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury. J Immunol. 2005 Nov 15; 175(10):6931-9. PMID: 16272353.
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    41. Strieter RM, Burdick MD, Gomperts BN, Belperio JA, Keane MP. CXC chemokines in angiogenesis. Cytokine Growth Factor Rev. 2005 Dec; 16(6):593-609. PMID: 16046180.
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    42. Belperio JA, Keane MP, Burdick MD, Gomperts B, Xue YY, Hong K, Mestas J, Ardehali A, Mehrad B, Saggar R, Lynch JP, Ross DJ, Strieter RM. Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome. J Clin Invest. 2005 May; 115(5):1150-62. PMID: 15864347.
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    43. Gomperts BN, Gong-Cooper X, Hackett BP. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J Cell Sci. 2004 Mar 15; 117(Pt 8):1329-37. PMID: 14996907.
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