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Brigitte N Gomperts

Title(s)Professor, Pediatrics
SchoolMedicine
Address760 Westwood Plaza 12-311
Los Angeles CA 90024
Phone56708
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    Other Positions
    Title(s)Professor, Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    Validation of an in vitro model of progressive fibrosis that mimics Idiopathic Pulmonary Fibrosis
    NIH U01HL153000Feb 15, 2021 - Jan 31, 2025
    Role: Principal Investigator
    Developing a targeted chemoprevention strategy for Non-Small Cell Lung Cancer
    NIH R01CA208303Aug 15, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Development of a High-Throughput Screen for Pre-therapeutic Discovery in Idiopathic Pulmonary Fibrosis
    NIH R01GM114259Mar 1, 2015 - Feb 28, 2019
    Role: Principal Investigator
    Progenitor Cells in Airway Repair
    NIH R01HL094561Sep 1, 2009 - Aug 31, 2014
    Role: Principal Investigator
    Cytokine Regulation of the Pulmonary Epithelium
    NIH K08HL074229Dec 15, 2004 - Nov 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition. Nat Commun. 2021 03 25; 12(1):1876. Mullen PJ, Garcia G, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. PMID: 33767183.
      View in: PubMed   Mentions:    Fields:    
    2. Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response. Cell Stem Cell. 2020 12 03; 27(6):869-875.e4. Purkayastha A, Sen C, Garcia G, Langerman J, Shia DW, Meneses LK, Vijayaraj P, Durra A, Koloff CR, Freund DR, Chi J, Rickabaugh TM, Mulay A, Konda B, Sim MS, Stripp BR, Plath K, Arumugaswami V, Gomperts BN. PMID: 33259798.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    3. Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging. Cell Stem Cell. 2020 Sep 03; 27(3):413-429.e4. Aros CJ, Vijayaraj P, Pantoja CJ, Bisht B, Meneses LK, Sandlin JM, Tse JA, Chen MW, Purkayastha A, Shia DW, Sucre JMS, Rickabaugh TM, Vladar EK, Paul MK, Gomperts BN. PMID: 32721381.
      View in: PubMed   Mentions:    Fields:    
    4. High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis. Cell Rep. 2020 02 18; 30(7):2055-2064.e5. Aros CJ, Paul MK, Pantoja CJ, Bisht B, Meneses LK, Vijayaraj P, Sandlin JM, France B, Tse JA, Chen MW, Shia DW, Rickabaugh TM, Damoiseaux R, Gomperts BN. PMID: 32075752.
      View in: PubMed   Mentions:    Fields:    
    5. Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Cell Rep. 2019 12 10; 29(11):3488-3505.e9. Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros CJ, Ahadome SD, Shia DW, Chung K, Sandlin JM, Darmawan KF, Bhatt KV, Manze CC, Paul MK, Wilkinson DC, Yan W, Clark AT, Rickabaugh TM, Wallace WD, Graeber TG, Damoiseaux R, Gomperts BN. PMID: 31825831.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies. Cancer Cell. 2019 07 08; 36(1):17-34.e7. Balanis NG, Sheu KM, Esedebe FN, Patel SJ, Smith BA, Park JW, Alhani S, Gomperts BN, Huang J, Witte ON, Graeber TG. PMID: 31287989.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    7. Correction to: Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2019 Feb 12; 10(1):52. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. PMID: 30755264.
      View in: PubMed   Mentions:    Fields:    
    8. Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling. Curr Protoc Stem Cell Biol. 2018 08; 46(1):e56. Wilkinson DC, Mellody M, Meneses LK, Hope AC, Dunn B, Gomperts BN. PMID: 29927098.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells. Cancer Res. 2018 04 15; 78(8):1986-1999. Walser TC, Jing Z, Tran LM, Lin YQ, Yakobian N, Wang G, Krysan K, Zhu LX, Sharma S, Lee MH, Belperio JA, Ooi AT, Gomperts BN, Shay JW, Larsen JE, Minna JD, Hong LS, Fishbein MC, Dubinett SM. PMID: 29431637.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2017 10 02; 8(1):217. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. PMID: 28969679.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. The aCCR(2)ual of M2 Macrophages Provides Some Breathing Room. Cell Stem Cell. 2017 07 06; 21(1):1-3. Vijayaraj P, Gomperts BN. PMID: 28686859.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling. Stem Cells Transl Med. 2017 02; 6(2):622-633. Wilkinson DC, Alva-Ornelas JA, Sucre JM, Vijayaraj P, Durra A, Richardson W, Jonas SJ, Paul MK, Karumbayaram S, Dunn B, Gomperts BN. PMID: 28191779.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    13. A three-dimensional human model of the fibroblast activation that accompanies bronchopulmonary dysplasia identifies Notch-mediated pathophysiology. . 2016 05 15; 310(10):L889-98. Sucre JM, Wilkinson D, Vijayaraj P, Paul M, Dunn B, Alva-Ornelas JA, Gomperts BN. PMID: 26968771.
      View in: PubMed   Mentions:
    14. Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA. Clin Cancer Res. 2015 Jun 01; 21(11):2440-4. Ooi AT, Gomperts BN. PMID: 25838393.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    15. Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling. Cell Stem Cell. 2014 Aug 07; 15(2):199-214. Paul MK, Bisht B, Darmawan DO, Chiou R, Ha VL, Wallace WD, Chon AT, Hegab AE, Grogan T, Elashoff DA, Alva-Ornelas JA, Gomperts BN. PMID: 24953182.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    16. Induction of multiciliated cells from induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):6120-1. Gomperts BN. PMID: 24740182.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. Cancer Prev Res (Phila). 2014 May; 7(5):487-95. Ooi AT, Gower AC, Zhang KX, Vick JL, Hong L, Nagao B, Wallace WD, Elashoff DA, Walser TC, Dubinett SM, Pellegrini M, Lenburg ME, Spira A, Gomperts BN. PMID: 24618292.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    18. Aldehyde dehydrogenase activity enriches for proximal airway basal stem cells and promotes their proliferation. Stem Cells Dev. 2014 Mar 15; 23(6):664-75. Hegab AE, Ha VL, Bisht B, Darmawan DO, Ooi AT, Zhang KX, Paul MK, Kim YS, Gilbert JL, Attiga YS, Alva-Ornelas JA, Nickerson DW, Gomperts BN. PMID: 24171691.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    19. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18946-51. Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A. PMID: 24158479.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    20. Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer. Cancer Prev Res (Phila). 2013 Jan; 6(1):4-7. Gomperts BN, Walser TC, Spira A, Dubinett SM. PMID: 23233734.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    21. Repair and regeneration of tracheal surface epithelium and submucosal glands in a mouse model of hypoxic-ischemic injury. Respirology. 2012 Oct; 17(7):1101-13. Hegab AE, Nickerson DW, Ha VL, Darmawan DO, Gomperts BN. PMID: 22617027.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    22. Isolation and in vitro characterization of basal and submucosal gland duct stem/progenitor cells from human proximal airways. Stem Cells Transl Med. 2012 Oct; 1(10):719-24. Hegab AE, Ha VL, Darmawan DO, Gilbert JL, Ooi AT, Attiga YS, Bisht B, Nickerson DW, Gomperts BN. PMID: 23197663.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    23. Isolation of basal cells and submucosal gland duct cells from mouse trachea. J Vis Exp. 2012 Sep 14; (67):e3731. Hegab AE, Ha VL, Attiga YS, Nickerson DW, Gomperts BN. PMID: 23007468.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    24. Identification of an interleukin 13-induced epigenetic signature in allergic airway inflammation. Am J Transl Res. 2012; 4(2):219-28. Ooi AT, Ram S, Kuo A, Gilbert JL, Yan W, Pellegrini M, Nickerson DW, Chatila TA, Gomperts BN. PMID: 22611474.
      View in: PubMed   Mentions:
    25. Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential. Stem Cells. 2011 Aug; 29(8):1283-93. Hegab AE, Ha VL, Gilbert JL, Zhang KX, Malkoski SP, Chon AT, Darmawan DO, Bisht B, Ooi AT, Pellegrini M, Nickerson DW, Gomperts BN. PMID: 21710468.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    26. Evolving concepts in lung carcinogenesis. Semin Respir Crit Care Med. 2011 Feb; 32(1):32-43. Gomperts BN, Spira A, Massion PP, Walser TC, Wistuba II, Minna JD, Dubinett SM. PMID: 21500122.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    27. B-acute lymphoblastic leukemia and cystinuria in a patient with duplication 22q11.21 detected by chromosomal microarray analysis. Pediatr Blood Cancer. 2011 Mar; 56(3):470-3. Chang VY, Quintero-Rivera F, Baldwin EE, Woo K, Martinez-Agosto JA, Fu C, Gomperts BN. PMID: 21225931.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    28. Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer. Cancer Res. 2010 Aug 15; 70(16):6639-48. Ooi AT, Mah V, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh EL, Chia D, Gower AC, Lenburg ME, Spira A, Solis LM, Wistuba II, Walser TC, Wallace WD, Dubinett SM, Goodglick L, Gomperts BN. PMID: 20710044.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    29. Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection. Cancer Prev Res (Phila). 2010 Apr; 3(4):420-3. Gomperts BN, Spira A, Elashoff DE, Dubinett SM. PMID: 20332300.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Quantification of cytokeratin 5 mRNA expression in the circulation of healthy human subjects and after lung transplantation. PLoS One. 2009 Jun 16; 4(6):e5925. Nickerson DW, Presson AP, Weigt SS, Gregson AL, Belperio JA, Gomperts BN. PMID: 19529775.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    31. Index of suspicion. Pediatr Rev. 2009 Jan; 30(1):15-21. Bekmezian A, Gomperts B, Weisleder P, Patraitis C, Thibodeau P, Parker-Mello K. PMID: 19118138.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Case 1: A limping child...with abdominal pain. Paediatr Child Health. 2008 Nov; 13(9):775-7. Bekmezian A, Gomperts B. PMID: 19436540.
      View in: PubMed   Mentions:
    33. Circulating progenitor cells in chronic lung disease. Expert Rev Respir Med. 2007 Aug; 1(1):157-65. Mehrad B, Keane MP, Gomperts BN, Strieter RM. PMID: 20477275.
      View in: PubMed   Mentions: 2     Fields:    
    34. Fibrocytes in lung disease. J Leukoc Biol. 2007 Sep; 82(3):449-56. Gomperts BN, Strieter RM. PMID: 17550974.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    35. IL-13 regulates cilia loss and foxj1 expression in human airway epithelium. Am J Respir Cell Mol Biol. 2007 Sep; 37(3):339-46. Gomperts BN, Kim LJ, Flaherty SA, Hackett BP. PMID: 17541011.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    36. Keratinocyte growth factor improves repair in the injured tracheal epithelium. Am J Respir Cell Mol Biol. 2007 Jul; 37(1):48-56. Gomperts BN, Belperio JA, Fishbein MC, Keane MP, Burdick MD, Strieter RM. PMID: 17332441.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    37. The role of CXC chemokines in pulmonary fibrosis. J Clin Invest. 2007 Mar; 117(3):549-56. Strieter RM, Gomperts BN, Keane MP. PMID: 17332882.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    38. Stem cells and chronic lung disease. Annu Rev Med. 2007; 58:285-98. Gomperts BN, Strieter RM. PMID: 16886904.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    39. IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. J Immunol. 2007 Jan 01; 178(1):511-9. Keane MP, Gomperts BN, Weigt S, Xue YY, Burdick MD, Nakamura H, Zisman DA, Ardehali A, Saggar R, Lynch JP, Hogaboam C, Kunkel SL, Lukacs NW, Ross DJ, Grusby MJ, Strieter RM, Belperio JA. PMID: 17182591.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    40. Cancer CXC chemokine networks and tumour angiogenesis. Eur J Cancer. 2006 Apr; 42(6):768-78. Strieter RM, Burdick MD, Mestas J, Gomperts B, Keane MP, Belperio JA. PMID: 16510280.
      View in: PubMed   Mentions: 135     Fields:    Translation:Humans
    41. Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury. J Immunol. 2006 Feb 01; 176(3):1916-27. Gomperts BN, Belperio JA, Rao PN, Randell SH, Fishbein MC, Burdick MD, Strieter RM. PMID: 16424223.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    42. Chemokine-directed metastasis. Contrib Microbiol. 2006; 13:170-190. Gomperts BN, Strieter RM. PMID: 16627965.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    43. CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury. J Immunol. 2005 Nov 15; 175(10):6931-9. Belperio JA, Keane MP, Burdick MD, Gomperts BN, Xue YY, Hong K, Mestas J, Zisman D, Ardehali A, Saggar R, Lynch JP, Ross DJ, Strieter RM. PMID: 16272353.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    44. CXC chemokines in angiogenesis. Cytokine Growth Factor Rev. 2005 Dec; 16(6):593-609. Strieter RM, Burdick MD, Gomperts BN, Belperio JA, Keane MP. PMID: 16046180.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    45. Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome. J Clin Invest. 2005 May; 115(5):1150-62. Belperio JA, Keane MP, Burdick MD, Gomperts B, Xue YY, Hong K, Mestas J, Ardehali A, Mehrad B, Saggar R, Lynch JP, Ross DJ, Strieter RM. PMID: 15864347.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    46. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J Cell Sci. 2004 Mar 15; 117(Pt 8):1329-37. Gomperts BN, Gong-Cooper X, Hackett BP. PMID: 14996907.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
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