Orian Shirihai

Title(s)Professor, Medicine
SchoolMedicine
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    Other Positions
    Title(s)Professor, Molecular and Medical Pharmacology


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    MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES
    NIH R41ES031043May 20, 2020 - Apr 30, 2021
    Role: Co-Principal Investigator
    A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles
    NIH R21AG060456Apr 15, 2019 - Feb 28, 2021
    Role: Principal Investigator
    R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD
    NIH R21AG063373Apr 1, 2019 - Jan 31, 2021
    Role: Co-Principal Investigator
    OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA
    NIH R01CA232056Feb 1, 2019 - Jan 31, 2024
    Role: Co-Principal Investigator
    Mitochondrial regulation of energy efficiency
    NIH R01DK099618Apr 1, 2014 - Mar 31, 2020
    Role: Principal Investigator
    Mitochondrial dynamics in beta cell function and dysfunction
    NIH R01DK074778Apr 1, 2006 - Jul 31, 2017
    Role: Principal Investigator
    Metabolic Profiling of Pancreatic Beta Cells
    NIH R21DK070303Sep 30, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Erythroid transporter function in hemoglobin synthesis
    NIH R01HL071629Dec 3, 2002 - Nov 30, 2008
    Role: Principal Investigator
    Metabolic Signal Transduction in Adipocytes
    NIH R01DK056690Dec 1, 1999 - Jan 31, 2017
    Role: Co-Principal Investigator
    Metabolic Regulation of Insulin Secretion
    NIH R56DK035914Jan 1, 1987 - May 31, 2010
    Role: Co-Principal Investigator
    Metabolic Regulation of Insulin Secretion
    NIH R01DK035914Jul 1, 1985 - Dec 30, 2014
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mitoquinone mesylate targets SARS-CoV-2 and associated lung inflammation through host pathways. bioRxiv. 2022 Mar 09. Petcherski A, Sharma M, Daskou M, Satta S, Vasilopoulos H, Hugo C, Ritou E, Dillon BJ, Fung E, Garcia G, Scafoglio C, Purkayastha A, Gomperts BN, Fishbein GA, Arumugaswami V, Liesa M, Shirihai OS, Kelesidis T. PMID: 35233569; PMCID: PMC8887067.
      View in: PubMed   Mentions:
    2. The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells. Virulence. 2021 12; 12(1):2214-2227. Kelesidis T, Madhav S, Petcherski A, Cristelle H, O'Connor E, Hultgren NW, Ritou E, Williams DS, Shirihai OS, Reddy ST. PMID: 34494942; PMCID: PMC8437485.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance. Mol Metab. 2022 01; 55:101403. Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M. PMID: 34823065; PMCID: PMC8689243.
      View in: PubMed   Mentions:
    4. DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer. Commun Biol. 2021 11 16; 4(1):1289. Shen N, Korm S, Karantanos T, Li D, Zhang X, Ritou E, Xu H, Lam A, English J, Zong WX, Liu CT, Shirihai O, Feng H. PMID: 34785772; PMCID: PMC8595664.
      View in: PubMed   Mentions:
    5. ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity. Rev Endocr Metab Disord. 2022 02; 23(1):121-131. Brownstein AJ, Veliova M, Acin-Perez R, Liesa M, Shirihai OS. PMID: 34741717; PMCID: PMC8873062.
      View in: PubMed   Mentions:
    6. Mitochondrial Heterogeneity in Metabolic Diseases. Biology (Basel). 2021 Sep 17; 10(9). Ngo J, Osto C, Villalobos F, Shirihai OS. PMID: 34571805; PMCID: PMC8470264.
      View in: PubMed   Mentions:
    7. Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives. Life (Basel). 2021 Sep 10; 11(9). Acin-Perez R, Benincá C, Shabane B, Shirihai OS, Stiles L. PMID: 34575097; PMCID: PMC8467772.
      View in: PubMed   Mentions:
    8. Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Rep. 2021 08 31; 36(9):109636. Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. PMID: 34469722; PMCID: PMC8432578.
      View in: PubMed   Mentions:
    9. Recruitment and remodeling of peridroplet mitochondria in human adipose tissue. Redox Biol. 2021 10; 46:102087. Acín-Perez R, Petcherski A, Veliova M, Benador IY, Assali EA, Colleluori G, Cinti S, Brownstein AJ, Baghdasarian S, Livhits MJ, Yeh MW, Krishnan KC, Vergnes L, Winn NC, Padilla J, Liesa M, Sacks HS, Shirihai OS. PMID: 34411987; PMCID: PMC8377484.
      View in: PubMed   Mentions:    Fields:    
    10. IRGM1 links mitochondrial quality control to autoimmunity. Nat Immunol. 2021 03; 22(3):312-321. Rai P, Janardhan KS, Meacham J, Madenspacher JH, Lin WC, Karmaus PWF, Martinez J, Li QZ, Yan M, Zeng J, Grinstaff MW, Shirihai OS, Taylor GA, Fessler MB. PMID: 33510463; PMCID: PMC7906953.
      View in: PubMed   Mentions:
    11. High-Throughput Image Analysis of Lipid-Droplet-Bound Mitochondria. Methods Mol Biol. 2021; 2276:285-303. Miller N, Wolf D, Alsabeeh N, Mahdaviani K, Segawa M, Liesa M, Shirihai OS. PMID: 34060050.
      View in: PubMed   Mentions:
    12. Isolation and functional analysis of peridroplet mitochondria from murine brown adipose tissue. STAR Protoc. 2021 03 19; 2(1):100243. Ngo J, Benador IY, Brownstein AJ, Vergnes L, Veliova M, Shum M, Acín-Pérez R, Reue K, Shirihai OS, Liesa M. PMID: 33458705; PMCID: PMC7797917.
      View in: PubMed   Mentions: 1  
    13. Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling. EMBO Rep. 2020 12 03; 21(12):e49634. Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein AJ, Desousa BR, Acín-Pérez R, Petcherski A, Assali EA, Stiles L, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, Shirihai OS. PMID: 33275313; PMCID: PMC7726774.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    14. Measuring Mitochondrial Respiration in Previously Frozen Biological Samples. Curr Protoc Cell Biol. 2020 12; 89(1):e116. Osto C, Benador IY, Ngo J, Liesa M, Stiles L, Acin-Perez R, Shirihai OS. PMID: 33320426.
      View in: PubMed   Mentions:
    15. Modulating lysosomal pH: a molecular and nanoscale materials design perspective. J Life Sci (Westlake Village). 2020 Dec; 2(4):25-37. Zeng J, Shirihai OS, Grinstaff MW. PMID: 33403369; PMCID: PMC7781074.
      View in: PubMed   Mentions:
    16. Mitochondrial oxidative function in NAFLD: Friend or foe? Mol Metab. 2021 08; 50:101134. Shum M, Ngo J, Shirihai OS, Liesa M. PMID: 33276146; PMCID: PMC8324685.
      View in: PubMed   Mentions:
    17. Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics. Front Cell Dev Biol. 2020; 8:592035. Gonzalez-Ibanez AM, Ruiz LM, Jensen E, Echeverria CA, Romero V, Stiles L, Shirihai OS, Elorza AA. PMID: 33330472; PMCID: PMC7719720.
      View in: PubMed   Mentions:
    18. Forces, fluxes, and fuels: tracking mitochondrial metabolism by integrating measurements of membrane potential, respiration, and metabolites. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C80-C91. Jones AE, Sheng L, Acevedo A, Veliova M, Shirihai OS, Stiles L, Divakaruni AS. PMID: 33147057; PMCID: PMC7846976.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity. Nat Metab. 2020 09; 2(9):974-988. Acín-Pérez R, Iborra S, Martí-Mateos Y, Cook ECL, Conde-Garrosa R, Petcherski A, Muñoz MDM, Martínez de Mena R, Krishnan KC, Jiménez C, Bolaños JP, Laakso M, Lusis AJ, Shirihai OS, Sancho D, Enríquez JA. PMID: 32943786; PMCID: PMC8225238.
      View in: PubMed   Mentions: 9  Translation:AnimalsCells
    20. Ellagic Acid and Its Microbial Metabolite Urolithin A Alleviate Diet-Induced Insulin Resistance in Mice. Mol Nutr Food Res. 2020 10; 64(19):e2000091. Yang J, Guo Y, Henning SM, Chan B, Long J, Zhong J, Acin-Perez R, Petcherski A, Shirihai O, Heber D, Li Z. PMID: 32783299.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    21. A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake. Redox Biol. 2020 10; 37:101676. Cerqueira FM, von Stockum S, Giacomello M, Goliand I, Kakimoto P, Marchesan E, De Stefani D, Kowaltowski AJ, Ziviani E, Shirihai OS. PMID: 32956978; PMCID: PMC7509235.
      View in: PubMed   Mentions:
    22. Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Sci Transl Med. 2020 08 05; 12(555). Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. PMID: 32759275; PMCID: PMC8212422.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    23. NCLX prevents cell death during adrenergic activation of the brown adipose tissue. Nat Commun. 2020 07 03; 11(1):3347. Assali EA, Jones AE, Veliova M, Acín-Pérez R, Taha M, Miller N, Shum M, Oliveira MF, Las G, Liesa M, Sekler I, Shirihai OS. PMID: 32620768; PMCID: PMC7334226.
      View in: PubMed   Mentions:
    24. Reply to: In vivo quantification of mitochondrial membrane potential. Nature. 2020 07; 583(7815):E19-E20. Momcilovic M, Shirihai O, Murphy MP, Koehler CM, Sadeghi S, Shackelford DB. PMID: 32641810.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    25. Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria. Life Sci Alliance. 2020 07; 3(7). Segawa M, Wolf DM, Hultgren NW, Williams DS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. PMID: 32499316; PMCID: PMC7283135.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. The biology of lipid droplet-bound mitochondria. Semin Cell Dev Biol. 2020 12; 108:55-64. Veliova M, Petcherski A, Liesa M, Shirihai OS. PMID: 32446655; PMCID: PMC8019155.
      View in: PubMed   Mentions:
    27. A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO J. 2020 07 01; 39(13):e104073. Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. PMID: 32432379; PMCID: PMC7327496.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    28. COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10. J Biol Chem. 2020 05 01; 295(18):6023-6042. Bradley MC, Yang K, Fernández-Del-Río L, Ngo J, Ayer A, Tsui HS, Novales NA, Stocker R, Shirihai OS, Barros MH, Clarke CF. PMID: 32205446; PMCID: PMC7196636.
      View in: PubMed   Mentions:
    29. Method for live-cell super-resolution imaging of mitochondrial cristae and quantification of submitochondrial membrane potentials. Methods Cell Biol. 2020; 155:545-555. Wolf DM, Segawa M, Shirihai OS, Liesa M. PMID: 32183976; PMCID: PMC7216778.
      View in: PubMed   Mentions:
    30. Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner. EMBO Rep. 2020 03 04; 21(3):e49776. Kondadi AK, Anand R, Hänsch S, Urbach J, Zobel T, Wolf DM, Segawa M, Liesa M, Shirihai OS, Weidtkamp-Peters S, Reichert AS. PMID: 32067344; PMCID: PMC7054676.
      View in: PubMed   Mentions:
    31. MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy. Biochem J. 2020 01 31; 477(2):461-475. Cerqueira FM, Kozer N, Petcherski A, Baranovski BM, Wolf D, Assali EA, Roth Y, Gazit R, Barr H, Lewis EC, Las G, Shirihai OS. PMID: 32003437.
      View in: PubMed   Mentions:
    32. Emerging roles of β-cell mitochondria in type-2-diabetes. Mol Aspects Med. 2020 02; 71:100843. Las G, Oliveira MF, Shirihai OS. PMID: 31918997.
      View in: PubMed   Mentions:
    33. Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2020 01; 577(7791):E7. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31896820.
      View in: PubMed   Mentions:    Fields:    
    34. Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels. Diabetes. 2020 02; 69(2):131-145. Taddeo EP, Alsabeeh N, Baghdasarian S, Wikstrom JD, Ritou E, Sereda S, Erion K, Li J, Stiles L, Abdulla M, Swanson Z, Wilhelm JJ, Bellin MD, Kibbey RG, Liesa M, Shirihai OS. PMID: 31740442; PMCID: PMC6971491.
      View in: PubMed   Mentions:
    35. Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2019 Nov; 575(7783):E5. Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N. PMID: 31695192.
      View in: PubMed   Mentions:
    36. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019 11; 575(7782):380-384. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31666695; PMCID: PMC7328016.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    37. Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. EMBO J. 2019 11 15; 38(22):e101056. Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. PMID: 31609012; PMCID: PMC6856616.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    38. Mitochondrial morphology regulates organellar Ca2+ uptake and changes cellular Ca2+ homeostasis. FASEB J. 2019 12; 33(12):13176-13188. Kowaltowski AJ, Menezes-Filho SL, Assali EA, Gonçalves IG, Cabral-Costa JV, Abreu P, Miller N, Nolasco P, Laurindo FRM, Bruni-Cardoso A, Shirihai OS. PMID: 31480917.
      View in: PubMed   Mentions:
    39. Publisher Correction: IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function. Nat Commun. 2019 Jul 31; 10(1):3507. Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. PMID: 31366929; PMCID: PMC6668385.
      View in: PubMed   Mentions:    Fields:    
    40. Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos. Cell Rep. 2019 07 16; 28(3):759-772.e10. Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG. PMID: 31315053; PMCID: PMC6713209.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    41. IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function. Nat Commun. 2019 06 18; 10(1):2679. Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. PMID: 31213603; PMCID: PMC6581914.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    42. To Fis or not to Fuse? This is the question! EMBO J. 2019 04 15; 38(8). Liesa M, Van der Bliek A, Shirihai OS. PMID: 30936092; PMCID: PMC6463207.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    43. Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization. Cell Metab. 2019 04 02; 29(4):827-835. Benador IY, Veliova M, Liesa M, Shirihai OS. PMID: 30905670; PMCID: PMC6476311.
      View in: PubMed   Mentions:
    44. A Thermogenic-Like Brown Adipose Tissue Phenotype Is Dispensable for Enhanced Glucose Tolerance in Female Mice. Diabetes. 2019 09; 68(9):1717-1729. Winn NC, Acin-Perez R, Woodford ML, Hansen SA, Haney MM, Ayedun LA, Rector RS, Vieira-Potter VJ, Shirihai OS, Sacks HS, Kanaley JA, Padilla J. PMID: 30862679; PMCID: PMC6702635.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    45. The OXPHOS supercomplex assembly factor HIG2A responds to changes in energetic metabolism and cell cycle. J Cell Physiol. 2019 08; 234(10):17405-17419. Salazar C, Elorza AA, Cofre G, Ruiz-Hincapie P, Shirihai O, Ruiz LM. PMID: 30779122.
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    46. Degradable Nanoparticles Restore Lysosomal pH and Autophagic Flux in Lipotoxic Pancreatic Beta Cells. Adv Healthc Mater. 2019 06; 8(12):e1801511. Zeng J, Shirihai OS, Grinstaff MW. PMID: 30698920.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    47. Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in β cells under lipotoxicity. FASEB J. 2019 03; 33(3):4154-4165. Assali EA, Shlomo D, Zeng J, Taddeo EP, Trudeau KM, Erion KA, Colby AH, Grinstaff MW, Liesa M, Las G, Shirihai OS. PMID: 30550357; PMCID: PMC8793810.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    48. The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Mol Metab. 2019 03; 21:51-67. Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL. PMID: 30591411; PMCID: PMC6407367.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    49. Individual islet respirometry reveals functional diversity within the islet population of mice and human donors. Mol Metab. 2018 10; 16:150-159. Taddeo EP, Stiles L, Sereda S, Ritou E, Wolf DM, Abdullah M, Swanson Z, Wilhelm J, Bellin M, McDonald P, Caradonna K, Neilson A, Liesa M, Shirihai OS. PMID: 30098928; PMCID: PMC6157638.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    50. Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling. iScience. 2018 Jul 27; 5:99-109. Waters LR, Ahsan FM, Wolf DM, Shirihai O, Teitell MA. PMID: 30240649; PMCID: PMC6123864.
      View in: PubMed   Mentions: 49  
    51. A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer Metab. 2018; 6:7. Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. PMID: 29988332; PMCID: PMC6022704.
      View in: PubMed   Mentions: 4  
    52. Mitochondrial adaptation in obesity is a ClpPicated business. EMBO Rep. 2018 06; 19(6). Liesa M, Shirihai OS. PMID: 29789387; PMCID: PMC5989752.
      View in: PubMed   Mentions: Translation:HumansCells
    53. Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency. EMBO J. 2018 05 15; 37(10). Rodríguez-Nuevo A, Díaz-Ramos A, Noguera E, Díaz-Sáez F, Duran X, Muñoz JP, Romero M, Plana N, Sebastián D, Tezze C, Romanello V, Ribas F, Seco J, Planet E, Doctrow SR, González J, Borràs M, Liesa M, Palacín M, Vendrell J, Villarroya F, Sandri M, Shirihai O, Zorzano A. PMID: 29632021; PMCID: PMC5978453.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    54. Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion. Cell Metab. 2018 04 03; 27(4):869-885.e6. Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF, Cinti S, Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE, Liesa M, Shirihai OS. PMID: 29617645; PMCID: PMC5969538.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    55. Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. J Biol Chem. 2018 03 30; 293(13):4735-4751. Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. PMID: 29378845; PMCID: PMC5880140.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    56. Cell culture models of fatty acid overload: Problems and solutions. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Feb; 1863(2):143-151. Alsabeeh N, Chausse B, Kakimoto PA, Kowaltowski AJ, Shirihai O. PMID: 29155055; PMCID: PMC5969525.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    57. Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line. Cell Cycle. 2017; 16(21):2086-2099. Montemurro C, Vadrevu S, Gurlo T, Butler AE, Vongbunyong KE, Petcherski A, Shirihai OS, Satin LS, Braas D, Butler PC, Tudzarova S. PMID: 28820316; PMCID: PMC5731404.
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    66. Nanoparticle tumor localization, disruption of autophagosomal trafficking, and prolonged drug delivery improve survival in peritoneal mesothelioma. Biomaterials. 2016 09; 102:175-86. Liu R, Colby AH, Gilmore D, Schulz M, Zeng J, Padera RF, Shirihai O, Grinstaff MW, Colson YL. PMID: 27343465; PMCID: PMC4948582.
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    108. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 2012 Feb 17; 148(4):651-63. Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA. PMID: 22341440; PMCID: PMC3286017.
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    109. Role of mitofusin 2 in the renal stress response. PLoS One. 2012; 7(1):e31074. Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG. PMID: 22292091; PMCID: PMC3266928.
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    110. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. PLoS One. 2012; 7(1):e30200. Saadeh M, Ferrante TC, Kane A, Shirihai O, Corkey BE, Deeney JT. PMID: 22272304; PMCID: PMC3260220.
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    111. Mitochondrial dynamics: the intersection of form and function. Adv Exp Med Biol. 2012; 748:13-40. Ferree A, Shirihai O. PMID: 22729853; PMCID: PMC5967395.
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    112. Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Hum Mol Genet. 2012 Mar 01; 21(5):978-90. Gilkerson RW, De Vries RL, Lebot P, Wikstrom JD, Torgyekes E, Shirihai OS, Przedborski S, Schon EA. PMID: 22080835; PMCID: PMC3277306.
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    113. Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Diabetes. 2011 Nov; 60(11):2710-9. Robson-Doucette CA, Sultan S, Allister EM, Wikstrom JD, Koshkin V, Bhattacharjee A, Prentice KJ, Sereda SB, Shirihai OS, Wheeler MB. PMID: 21984579; PMCID: PMC3198081.
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    114. Fatty acids suppress autophagic turnover in β-cells. J Biol Chem. 2011 Dec 09; 286(49):42534-42544. Las G, Serada SB, Wikstrom JD, Twig G, Shirihai OS. PMID: 21859708; PMCID: PMC3234912.
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    115. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16; 124(7):806-13. Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS. PMID: 21788586; PMCID: PMC4491919.
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    116. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation. 2011 Jul 26; 124(4):444-53. Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE, Hamburg NM, Frame AA, Caiano TL, Kluge MA, Duess MA, Levit A, Kim B, Hartman ML, Joseph L, Shirihai OS, Vita JA. PMID: 21747057; PMCID: PMC3149100.
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    117. The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell. 2011 Jul 01; 22(13):2235-45. Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song WJ, Sereda S, Clerc P, Polster BM, Aja SM, Pletnikov MV, Kensler TW, Shirihai OS, Iijima M, Hussain MA, Sesaki H. PMID: 21551073; PMCID: PMC3128526.
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    118. The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal. 2011 May 15; 14(10):1939-51. Twig G, Shirihai OS. PMID: 21128700; PMCID: PMC3078508.
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    119. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011 Apr 01; 25(7):717-29. Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC. PMID: 21406549; PMCID: PMC3070934.
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    120. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011 Feb 17; 470(7334):359-65. Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. PMID: 21307849; PMCID: PMC3741661.
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    121. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature. 2010 Dec 02; 468(7324):659-63. Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N. PMID: 21124451; PMCID: PMC3037591.
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    122. Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C477-87. Twig G, Liu X, Liesa M, Wikstrom JD, Molina AJ, Las G, Yaniv G, Hajnóczky G, Shirihai OS. PMID: 20445168; PMCID: PMC2928626.
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    123. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 2010 Jan 22; 140(2):280-93. Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. PMID: 20141841; PMCID: PMC2821045.
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    124. Organellar vs cellular control of mitochondrial dynamics. Semin Cell Dev Biol. 2010 Aug; 21(6):575-81. Hyde BB, Twig G, Shirihai OS. PMID: 20079451; PMCID: PMC3808978.
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    125. Respiration in adipocytes is inhibited by reactive oxygen species. Obesity (Silver Spring). 2010 Aug; 18(8):1493-502. Wang T, Si Y, Shirihai OS, Si H, Schultz V, Corkey RF, Hu L, Deeney JT, Guo W, Corkey BE. PMID: 20035277; PMCID: PMC6154476.
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    126. Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One. 2009 Nov 24; 4(11):e7983. Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN. PMID: 19956695; PMCID: PMC2776992.
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    127. Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. J Immunol. 2009 Nov 15; 183(10):6313-9. Tagen M, Elorza A, Kempuraj D, Boucher W, Kepley CL, Shirihai OS, Theoharides TC. PMID: 19846869; PMCID: PMC2925218.
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    128. Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics. EMBO J. 2009 Oct 21; 28(20):3074-89. Liu X, Weaver D, Shirihai O, Hajnóczky G. PMID: 19745815; PMCID: PMC2771091.
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    129. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16263-8. Chen W, Paradkar PN, Li L, Pierce EL, Langer NB, Takahashi-Makise N, Hyde BB, Shirihai OS, Ward DM, Kaplan J, Paw BH. PMID: 19805291; PMCID: PMC2752562.
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    130. The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets. Obesity (Silver Spring). 2009 Oct; 17(10):1856-60. Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE. PMID: 19644453; PMCID: PMC3808997.
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    131. Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009 Oct; 58(10):2303-15. Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS. PMID: 19581419; PMCID: PMC2750232.
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    132. What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy? Int J Biochem Cell Biol. 2009 Oct; 41(10):1914-27. Wikstrom JD, Twig G, Shirihai OS. PMID: 19549572.
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    133. Frequency and selectivity of mitochondrial fusion are key to its quality maintenance function. Biophys J. 2009 May 06; 96(9):3509-18. Mouli PK, Twig G, Shirihai OS. PMID: 19413957; PMCID: PMC2711405.
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    134. Monitoring mitochondrial dynamics with photoactivatable [corrected] green fluorescent protein. Methods Enzymol. 2009; 457:289-304. Molina AJ, Shirihai OS. PMID: 19426874; PMCID: PMC5967387.
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    135. UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008 Nov 07; 283(45):30461-70. Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS. PMID: 18687678; PMCID: PMC2576537.
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    136. Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta. 2008 Sep; 1777(9):1092-7. Twig G, Hyde B, Shirihai OS. PMID: 18519024; PMCID: PMC3809017.
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    137. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. PMID: 18223655; PMCID: PMC3918232.
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    138. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 23; 27(2):433-46. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. PMID: 18200046; PMCID: PMC2234339.
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    139. beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 2007 Oct; 56(10):2569-78. Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS. PMID: 17686943.
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    140. Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 2007 Apr 01; 403(1):197-205. Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE. PMID: 17181533; PMCID: PMC1828901.
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    141. Direct interorganellar transfer of iron from endosome to mitochondrion. Blood. 2007 Jul 01; 110(1):125-32. Sheftel AD, Zhang AS, Brown C, Shirihai OS, Ponka P. PMID: 17376890.
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    142. PA-GFP: a window into the subcellular adventures of the individual mitochondrion. Novartis Found Symp. 2007; 287:21-36; discussion 36-46. Haigh SE, Twig G, Molina AA, Wikstrom JD, Deutsch M, Shirihai OS. PMID: 18074629.
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    143. A novel miniature cell retainer for correlative high-content analysis of individual untethered non-adherent cells. Lab Chip. 2006 Aug; 6(8):995-1000. Deutsch M, Deutsch A, Shirihai O, Hurevich I, Afrimzon E, Shafran Y, Zurgil N. PMID: 16874368.
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    144. Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP. Am J Physiol Cell Physiol. 2006 Jul; 291(1):C176-84. Twig G, Graf SA, Wikstrom JD, Mohamed H, Haigh SE, Elorza A, Deutsch M, Zurgil N, Reynolds N, Shirihai OS. PMID: 16481372.
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    145. Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells. Am J Physiol Endocrinol Metab. 2006 Jan; 290(1):E143-E148. Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE. PMID: 16144817.
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    146. Synergistic amplification of beta-amyloid- and interferon-gamma-induced microglial neurotoxic response by the senile plaque component chromogranin A. Am J Physiol Cell Physiol. 2005 Jan; 288(1):C169-75. Twig G, Graf SA, Messerli MA, Smith PJ, Yoo SH, Shirihai OS. PMID: 15342341.
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    147. Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). J Biol Chem. 2004 Oct 08; 279(41):42954-63. Graf SA, Haigh SE, Corson ED, Shirihai OS. PMID: 15215243.
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    148. SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell. 2002 Oct; 10(4):843-55. Best JL, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, Meluh PB, Pandolfi PP, Zon LI. PMID: 12419228.
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