Orian Shirihai

Title(s)Professor, Medicine
SchoolMedicine
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    Title(s)Professor, Molecular and Medical Pharmacology


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    MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES
    NIH R41ES031043May 20, 2020 - Apr 30, 2021
    Role: Co-Principal Investigator
    A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles
    NIH R21AG060456Apr 15, 2019 - Feb 28, 2021
    Role: Principal Investigator
    R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD
    NIH R21AG063373Apr 1, 2019 - Jan 31, 2021
    Role: Co-Principal Investigator
    OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA
    NIH R01CA232056Feb 1, 2019 - Jan 31, 2024
    Role: Co-Principal Investigator
    Mitochondrial regulation of energy efficiency
    NIH R01DK099618Apr 1, 2014 - Mar 31, 2020
    Role: Principal Investigator
    Mitochondrial dynamics in beta cell function and dysfunction
    NIH R01DK074778Apr 1, 2006 - Jul 31, 2017
    Role: Principal Investigator
    Metabolic Profiling of Pancreatic Beta Cells
    NIH R21DK070303Sep 30, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Erythroid transporter function in hemoglobin synthesis
    NIH R01HL071629Dec 3, 2002 - Nov 30, 2008
    Role: Principal Investigator
    Metabolic Signal Transduction in Adipocytes
    NIH R01DK056690Dec 1, 1999 - Jan 31, 2017
    Role: Co-Principal Investigator
    Metabolic Regulation of Insulin Secretion
    NIH R56DK035914Jan 1, 1987 - May 31, 2010
    Role: Co-Principal Investigator
    Metabolic Regulation of Insulin Secretion
    NIH R01DK035914Jul 1, 1985 - Dec 30, 2014
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: A human brain map of mitochondrial respiratory capacity and diversity. Nature. 2025 May 22. Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Junker A, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood MD, Boldrini M, Thiebaut de Schotten M, Picard M. PMID: 40404942.
      View in: PubMed   Mentions:    Fields:    
    2. A cold-inducible phospholipid-protein interaction in brown fat mitochondria optimizes thermogenic capacity. bioRxiv. 2025 May 18. Shimanaka Y, Tol MJ, Rocha-Roa C, Jellinek MJ, Cui L, Bender A, Bedard AH, Milner MG, Melillo B, Shoucri BM, Wong A, Williams KJ, Stiles L, Shum M, Weston TA, Cohn W, Whitelegge JP, Budin I, Bertholet AM, Cravatt BF, Young SG, Houten SM, Argmann C, Ford DA, Liesa M, Shirihai OS, Vanni S, Tontonoz P. PMID: 40463239; PMCID: PMC12132348.
      View in: PubMed   Mentions:
    3. Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males. Cell Rep Med. 2025 May 02; 102116. Zhou Z, Moore TM, Strumwasser AR, Ribas V, Iwasaki H, Morrow N, Ma A, Tran PH, Wanagat J, de Aguiar Vallim TQ, Clifford B, Zhang Z, Sallam T, Parks BW, Reue K, Shirihai O, Acin-Perez R, Morselli M, Pellegrini M, Mahata SK, Norheim F, Zhou M, Seldin MM, Lusis AJ, Lee CC, Goodarzi MO, Rotter JI, Hansen JR, Drucker B, Sagendorf TJ, Adkins JN, Sanford JA, DeMayo FJ, Hewitt SC, Korach KS, Hevener AL. PMID: 40328250.
      View in: PubMed   Mentions:    Fields:    
    4. A human brain map of mitochondrial respiratory capacity and diversity. Nature. 2025 May; 641(8063):749-758. Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Junker A, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood MD, Boldrini M, Thiebaut de Schotten M, Picard M. PMID: 40140564.
      View in: PubMed   Mentions: 2     Fields:    
    5. Mitochondrial reactive oxygen species regulate acetyl-CoA flux between cytokine production and fatty acid synthesis in effector T cells. Cell Rep. 2025 Mar 25; 44(3):115430. Wu B, Woo JS, Hasiakos S, Pan C, Cokus S, Benincá C, Stiles L, Sun Z, Pellegrini M, Shirihai OS, Lusis AJ, Srikanth S, Gwack Y. PMID: 40088449; PMCID: PMC12007815.
      View in: PubMed   Mentions:    Fields:    
    6. Endolysosome-targeted nanoparticle delivery of antiviral therapy for coronavirus infections. Life Sci Alliance. 2025 Apr; 8(4). Petcherski A, Tingley BM, Martin A, Adams S, Brownstein AJ, Steinberg RA, Shabane B, Ngo J, Osto C, Garcia G, Veliova M, Arumugaswami V, Colby AH, Shirihai OS, Grinstaff MW. PMID: 39900438; PMCID: PMC11790838.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy. bioRxiv. 2025 Feb 01. Levi-D'Ancona E, Walker EM, Zhu J, Deng Y, Sidarala V, Stendahl AM, Reck EC, Henry-Kanarek BA, Lietzke AC, Pasmooij MB, Hubers DL, Basrur V, Ghosh S, Stiles L, Nesvizhskii AI, Shirihai OS, Soleimanpour SA. PMID: 39974969; PMCID: PMC11838480.
      View in: PubMed   Mentions:
    8. Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation. EMBO Rep. 2025 Feb; 26(4):982-1002. Ball AB, Jones AE, Nguy?n KB, Rios A, Marx N, Hsieh WY, Yang K, Desousa BR, Kim KKO, Veliova M, Del Mundo ZM, Shirihai OS, Benincá C, Stiles L, Bensinger SJ, Divakaruni AS. PMID: 39753784; PMCID: PMC11850891.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Productive infection of the retinal pigment epithelium by SARS-CoV-2: Initial effects and consideration of long-term consequences. PNAS Nexus. 2024 Dec; 3(12):pgae500. Hultgren NW, Petcherski A, Torriano S, Komirisetty R, Sharma M, Zhou T, Burgess BL, Ngo J, Osto C, Shabane B, Shirihai OS, Kelesidis T, Williams DS. PMID: 39712068; PMCID: PMC11660945.
      View in: PubMed   Mentions:
    10. PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity. Proc Natl Acad Sci U S A. 2024 Dec 03; 121(49):e2416882121. Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Bhatia V, Han M, Abt ER, Park JW, Memarzadeh S, Shackelford DB, Lee JK, Graeber TG, Shirihai OS, Witte ON. PMID: 39589879; PMCID: PMC11626175.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction. Cell Rep Med. 2024 Nov 19; 5(11):101795. Li S, Tao B, Wan J, Montecino-Rodriguez E, Wang P, Ma F, Sun B, Gu Y, Ramadoss S, Su L, Sun Q, Hoeve JT, Stiles L, Collins J, van Dam RM, Tamboline M, Taschereau R, Shirihai O, Kitchen DB, Pellegrini M, Graeber T, Dorshkind K, Xu S, Deb A. PMID: 39454569; PMCID: PMC11604407.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Universal high-throughput image quantification of subcellular structure dynamics and spatial distributions within cells. bioRxiv. 2024 Oct 22. Martin A, Zhang S, Williamson A, Tingley B, Pickus M, Zurakowski D, Nia HT, Shirihai O, Han X, Grinstaff MW. PMID: 39229224; PMCID: PMC11370428.
      View in: PubMed   Mentions:
    13. Mfn2 induces NCLX-mediated calcium release from mitochondria. bioRxiv. 2024 Aug 13. Kolitsida P, Saha A, Caliri A, Assali E, Riera AM, Itskanov S, Magana CS, Stork B, Shirihai O, Sekler I, Koehler CM, van der Bliek AM. PMID: 39149365; PMCID: PMC11326197.
      View in: PubMed   Mentions:
    14. PGC-1α drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity. bioRxiv. 2024 Jul 25. Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Bhatia V, Han M, Abt ER, Park JW, Memarzadeh S, Shackelford D, Lee JK, Graeber T, Shirihai O, Witte O. PMID: 38645232; PMCID: PMC11030384.
      View in: PubMed   Mentions:
    15. NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis. Mol Metab. 2024 Sep; 87:101982. Taha M, Assali EA, Ben-Kasus Nissim T, Stutzmann GE, Shirihai OS, Hershfinkel M, Sekler I. PMID: 38960129; PMCID: PMC11325370.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Acidic Nanoparticles Restore Lysosomal Acidification and Rescue Metabolic Dysfunction in Pancreatic β-Cells under Lipotoxic Conditions. ACS Nano. 2024 06 18; 18(24):15452-15467. Lo CH, O'Connor LM, Loi GWZ, Saipuljumri EN, Indajang J, Lopes KM, Shirihai OS, Grinstaff MW, Zeng J. PMID: 38830624; PMCID: PMC11192035.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    17. Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respiration. bioRxiv. 2024 May 14. Ball AB, Jones AE, Nguy?n KB, Rios A, Marx N, Hsieh WY, Yang K, Desousa BR, Kim KKO, Veliova M, Del Mundo ZM, Shirihai OS, Benincá C, Stiles L, Bensinger SJ, Divakaruni AS. PMID: 38798678; PMCID: PMC11118427.
      View in: PubMed   Mentions:
    18. Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria. Sci Adv. 2024 Apr 05; 10(14):eadl0389. Zhou Z, Ma A, Moore TM, Wolf DM, Yang N, Tran P, Segawa M, Strumwasser AR, Ren W, Fu K, Wanagat J, van der Bliek AM, Crosbie-Watson R, Liesa M, Stiles L, Acin-Perez R, Mahata S, Shirihai O, Goodarzi MO, Handzlik M, Metallo CM, Walker DW, Hevener AL. PMID: 38569044; PMCID: PMC10990287.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    19. Role of the mitochondrial protein cyclophilin D in skin wound healing and collagen secretion. JCI Insight. 2024 Apr 02; 9(9). Bansal R, Torres M, Hunt M, Wang N, Chatzopoulou M, Manchanda M, Taddeo EP, Shu C, Shirihai OS, Bachar-Wikstrom E, Wikstrom JD. PMID: 38564292; PMCID: PMC11141914.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    20. Impaired AMPK Control of Alveolar Epithelial Cell Metabolism Promotes Pulmonary Fibrosis. bioRxiv. 2024 Mar 28. Rodriguez LR, Alysandratos KD, Katzen J, Murthy A, Barboza WR, Tomer Y, Acin-Perez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF. PMID: 38585863; PMCID: PMC10996612.
      View in: PubMed   Mentions:
    21. A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity. Res Sq. 2024 Mar 22. Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood M, Boldrini M, Thiebaut de Schotten M, Picard M. PMID: 38562777; PMCID: PMC10984021.
      View in: PubMed   Mentions:
    22. A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity. bioRxiv. 2024 Mar 07. Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood M, Boldrini M, de Schotten MT, Picard M. PMID: 38496679; PMCID: PMC10942385.
      View in: PubMed   Mentions: 1  
    23. Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2. bioRxiv. 2024 Feb 28. Wortham M, Ramms B, Zeng C, Benthuysen JR, Sai S, Pollow DP, Liu F, Schlichting M, Harrington AR, Liu B, Prakash TP, Pirie EC, Zhu H, Baghdasarian S, Auwerx J, Shirihai OS, Sander M. PMID: 38464227; PMCID: PMC10925077.
      View in: PubMed   Mentions:
    24. The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. J Biol Chem. 2024 03; 300(3):105702. Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. PMID: 38301896; PMCID: PMC10910128.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis. Redox Biol. 2024 04; 70:103052. Gutierrez V, Kim-Vasquez D, Shum M, Yang Q, Dikeman D, Louie SG, Shirihai OS, Tsukamoto H, Liesa M. PMID: 38290384; PMCID: PMC10844117.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    26. Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma. Cancer Res. 2024 01 16; 84(2):305-327. Saggese P, Pandey A, Alcaraz M, Fung E, Hall A, Yanagawa J, Rodriguez EF, Grogan TR, Giurato G, Nassa G, Salvati A, Shirihai OS, Weisz A, Dubinett SM, Scafoglio C. PMID: 37934116; PMCID: PMC10790128.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    27. Mitochondria isolated from lipid droplets of white adipose tissue reveal functional differences based on lipid droplet size. Life Sci Alliance. 2024 02; 7(2). Brownstein AJ, Veliova M, Acin-Perez R, Villalobos F, Petcherski A, Tombolato A, Liesa M, Shirihai OS. PMID: 38056907; PMCID: PMC10700548.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    28. A ketogenic diet can mitigate SARS-CoV-2 induced systemic reprogramming and inflammation. Commun Biol. 2023 11 03; 6(1):1115. Palermo A, Li S, Ten Hoeve J, Chellappa A, Morris A, Dillon B, Ma F, Wang Y, Cao E, Shabane B, Acín-Perez R, Petcherski A, Lusis AJ, Hazen S, Shirihai OS, Pellegrini M, Arumugaswami V, Graeber TG, Deb A. PMID: 37923961; PMCID: PMC10624922.
      View in: PubMed   Mentions: 4  Translation:AnimalsCells
    29. Regulation of Postnatal Cardiomyocyte Maturation by an RNA Splicing Regulator RBFox1. Circulation. 2023 10 17; 148(16):1263-1266. Huang J, Lee JZ, Rau CD, Pezhouman A, Yokota T, Miwa H, Feldman M, Kong TK, Yang Z, Tay WT, Pushkarsky I, Kim K, Parikh SS, Udani S, Soh BS, Gao C, Stiles L, Shirihai OS, Knollmann BC, Ardehali R, Di Carlo D, Wang Y. PMID: 37844148; PMCID: PMC10593507.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    30. MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer. Cell Rep. 2023 10 31; 42(10):113221. Crowell PD, Giafaglione JM, Jones AE, Nunley NM, Hashimoto T, Delcourt AML, Petcherski A, Agrawal R, Bernard MJ, Diaz JA, Heering KY, Huang RR, Low JY, Matulionis N, Navone NM, Ye H, Zoubeidi A, Christofk HR, Rettig MB, Reiter RE, Haffner MC, Boutros PC, Shirihai OS, Divakaruni AS, Goldstein AS. PMID: 37815914; PMCID: PMC11972006.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    31. The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. bioRxiv. 2023 Aug 16. Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. PMID: 37645724; PMCID: PMC10461965.
      View in: PubMed   Mentions:
    32. Calculation of ATP production rates using the Seahorse XF Analyzer. EMBO Rep. 2023 10 09; 24(10):e56380. Desousa BR, Kim KK, Jones AE, Ball AB, Hsieh WY, Swain P, Morrow DH, Brownstein AJ, Ferrick DA, Shirihai OS, Neilson A, Nathanson DA, Rogers GW, Dranka BP, Murphy AN, Affourtit C, Bensinger SJ, Stiles L, Romero N, Divakaruni AS. PMID: 37548091; PMCID: PMC10561364.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    33. Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. Nat Commun. 2023 05 04; 14(1):2573. Zeng J, Acin-Perez R, Assali EA, Martin A, Brownstein AJ, Petcherski A, Fernández-Del-Rio L, Xiao R, Lo CH, Shum M, Liesa M, Han X, Shirihai OS, Grinstaff MW. PMID: 37142604; PMCID: PMC10160018.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    34. Nutrient regulation of the islet epigenome controls adaptive insulin secretion. J Clin Invest. 2023 04 17; 133(8). Wortham M, Liu F, Harrington AR, Fleischman JY, Wallace M, Mulas F, Mallick M, Vinckier NK, Cross BR, Chiou J, Patel NA, Sui Y, McGrail C, Jun Y, Wang G, Jhala US, Schüle R, Shirihai OS, Huising MO, Gaulton KJ, Metallo CM, Sander M. PMID: 36821378; PMCID: PMC10104905.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    35. Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Nature. 2023 03; 615(7953):712-719. Han M, Bushong EA, Segawa M, Tiard A, Wong A, Brady MR, Momcilovic M, Wolf DM, Zhang R, Petcherski A, Madany M, Xu S, Lee JT, Poyurovsky MV, Olszewski K, Holloway T, Gomez A, John MS, Dubinett SM, Koehler CM, Shirihai OS, Stiles L, Lisberg A, Soatto S, Sadeghi S, Ellisman MH, Shackelford DB. PMID: 36922590; PMCID: PMC10033418.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    36. Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA. EMBO J. 2023 06 01; 42(11):e111901. Ngo J, Choi DW, Stanley IA, Stiles L, Molina AJA, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, Miller N, Baghdasarian S, Kim-Vasquez D, Jones AE, Roach B, Gutierrez V, Erion K, Divakaruni AS, Liesa M, Danial NN, Shirihai OS. PMID: 36917141; PMCID: PMC10233380.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    37. A novel approach to measure complex V ATP hydrolysis in frozen cell lysates and tissue homogenates. Life Sci Alliance. 2023 04; 6(4). Fernandez-Del-Rio L, Benincá C, Villalobos F, Shu C, Stiles L, Liesa M, Divakaruni AS, Acin-Perez R, Shirihai OS. PMID: 36918278; PMCID: PMC10019470.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    38. Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies. EMBO J. 2023 05 15; 42(10):e111699. Acin-Perez R, Benincá C, Fernandez Del Rio L, Shu C, Baghdasarian S, Zanette V, Gerle C, Jiko C, Khairallah R, Khan S, Rincon Fernandez Pacheco D, Shabane B, Erion K, Masand R, Dugar S, Ghenoiu C, Schreiner G, Stiles L, Liesa M, Shirihai OS. PMID: 36912136; PMCID: PMC10183817.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    39. Blood immune cells from people with HIV on antiviral regimens that contain tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) have differential metabolic signatures. Metabolism. 2023 04; 141:155395. Ritou E, Satta S, Petcherski A, Daskou M, Sharma M, Vasilopoulos H, Murakami E, Shirihai OS, Kelesidis T. PMID: 36842771; PMCID: PMC10932727.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsCTClinical Trials
    40. Measuring Mitochondrial Uncoupling in Mouse Primary Brown Adipocytes Differentiated Ex Vivo. Methods Mol Biol. 2023; 2662:53-65. Veliova M, Tol MJ, Tontonoz P, Shirihai OS, Liesa M. PMID: 37076670.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    41. Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas. Nat Commun. 2022 11 17; 13(1):7037. Do Rhee K, Wang Y, Ten Hoeve J, Stiles L, Nguyen TTT, Zhang X, Vergnes L, Reue K, Shirihai O, Bok D, Yang XJ. PMID: 36396639; PMCID: PMC9672129.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    42. Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes. Nat Commun. 2022 11 04; 13(1):6661. Moore TM, Cheng L, Wolf DM, Ngo J, Segawa M, Zhu X, Strumwasser AR, Cao Y, Clifford BL, Ma A, Scumpia P, Shirihai OS, Vallim TQA, Laakso M, Lusis AJ, Hevener AL, Zhou Z. PMID: 36333379; PMCID: PMC9636263.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    43. Mitochondrial signal transduction. Cell Metab. 2022 11 01; 34(11):1620-1653. Picard M, Shirihai OS. PMID: 36323233; PMCID: PMC9692202.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansCells
    44. The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR. Mol Metab. 2022 10; 64:101566. Steffen J, Ngo J, Wang SP, Williams K, Kramer HF, Ho G, Rodriguez C, Yekkala K, Amuzie C, Bialecki R, Norquay L, Nawrocki AR, Erion M, Pocai A, Shirihai OS, Liesa M. PMID: 35940556; PMCID: PMC9420962.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    45. TNFα-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice. Brain Sci. 2022 Jul 09; 12(7). Desai M, Stiles L, Torsoni AS, Torsoni MA, Shirihai OS, Ross MG. PMID: 35884707; PMCID: PMC9316209.
      View in: PubMed   Mentions: 2  
    46. Mitoquinone mesylate targets SARS-CoV-2 infection in preclinical models. bioRxiv. 2022 Jun 23. Petcherski A, Sharma M, Daskou M, Satta S, Vasilopoulos H, Hugo C, Ritou E, Dillon BJ, Fung E, Garcia G, Scafoglio C, Purkayastha A, Gomperts BN, Fishbein GA, Arumugaswami V, Liesa M, Shirihai OS, Kelesidis T. PMID: 35233569; PMCID: PMC8887067.
      View in: PubMed   Mentions: 1  
    47. The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells. Virulence. 2021 12; 12(1):2214-2227. Kelesidis T, Madhav S, Petcherski A, Cristelle H, O'Connor E, Hultgren NW, Ritou E, Williams DS, Shirihai OS, Reddy ST. PMID: 34494942; PMCID: PMC8437485.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    48. Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance. Mol Metab. 2022 01; 55:101403. Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M. PMID: 34823065; PMCID: PMC8689243.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    49. DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer. Commun Biol. 2021 11 16; 4(1):1289. Shen N, Korm S, Karantanos T, Li D, Zhang X, Ritou E, Xu H, Lam A, English J, Zong WX, Liu CT, Shirihai O, Feng H. PMID: 34785772; PMCID: PMC8595664.
      View in: PubMed   Mentions: 26  Translation:HumansCells
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    154. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 2012 Feb 17; 148(4):651-63. Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA. PMID: 22341440; PMCID: PMC3286017.
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    155. Role of mitofusin 2 in the renal stress response. PLoS One. 2012; 7(1):e31074. Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG. PMID: 22292091; PMCID: PMC3266928.
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    156. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. PLoS One. 2012; 7(1):e30200. Saadeh M, Ferrante TC, Kane A, Shirihai O, Corkey BE, Deeney JT. PMID: 22272304; PMCID: PMC3260220.
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    157. Mitochondrial dynamics: the intersection of form and function. Adv Exp Med Biol. 2012; 748:13-40. Ferree A, Shirihai O. PMID: 22729853; PMCID: PMC5967395.
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    158. Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Hum Mol Genet. 2012 Mar 01; 21(5):978-90. Gilkerson RW, De Vries RL, Lebot P, Wikstrom JD, Torgyekes E, Shirihai OS, Przedborski S, Schon EA. PMID: 22080835; PMCID: PMC3277306.
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    159. Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Diabetes. 2011 Nov; 60(11):2710-9. Robson-Doucette CA, Sultan S, Allister EM, Wikstrom JD, Koshkin V, Bhattacharjee A, Prentice KJ, Sereda SB, Shirihai OS, Wheeler MB. PMID: 21984579; PMCID: PMC3198081.
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    160. Fatty acids suppress autophagic turnover in β-cells. J Biol Chem. 2011 Dec 09; 286(49):42534-42544. Las G, Serada SB, Wikstrom JD, Twig G, Shirihai OS. PMID: 21859708; PMCID: PMC3234912.
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    161. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16; 124(7):806-13. Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS. PMID: 21788586; PMCID: PMC4491919.
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    162. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation. 2011 Jul 26; 124(4):444-53. Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE, Hamburg NM, Frame AA, Caiano TL, Kluge MA, Duess MA, Levit A, Kim B, Hartman ML, Joseph L, Shirihai OS, Vita JA. PMID: 21747057; PMCID: PMC3149100.
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    163. The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell. 2011 Jul 01; 22(13):2235-45. Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song WJ, Sereda S, Clerc P, Polster BM, Aja SM, Pletnikov MV, Kensler TW, Shirihai OS, Iijima M, Hussain MA, Sesaki H. PMID: 21551073; PMCID: PMC3128526.
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    164. The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal. 2011 May 15; 14(10):1939-51. Twig G, Shirihai OS. PMID: 21128700; PMCID: PMC3078508.
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    165. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011 Apr 01; 25(7):717-29. Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC. PMID: 21406549; PMCID: PMC3070934.
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    166. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011 Feb 17; 470(7334):359-65. Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. PMID: 21307849; PMCID: PMC3741661.
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    167. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature. 2010 Dec 02; 468(7324):659-63. Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N. PMID: 21124451; PMCID: PMC3037591.
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    168. Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C477-87. Twig G, Liu X, Liesa M, Wikstrom JD, Molina AJ, Las G, Yaniv G, Hajnóczky G, Shirihai OS. PMID: 20445168; PMCID: PMC2928626.
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    169. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 2010 Jan 22; 140(2):280-93. Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. PMID: 20141841; PMCID: PMC2821045.
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    170. Organellar vs cellular control of mitochondrial dynamics. Semin Cell Dev Biol. 2010 Aug; 21(6):575-81. Hyde BB, Twig G, Shirihai OS. PMID: 20079451; PMCID: PMC3808978.
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    171. Respiration in adipocytes is inhibited by reactive oxygen species. Obesity (Silver Spring). 2010 Aug; 18(8):1493-502. Wang T, Si Y, Shirihai OS, Si H, Schultz V, Corkey RF, Hu L, Deeney JT, Guo W, Corkey BE. PMID: 20035277; PMCID: PMC6154476.
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    172. Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One. 2009 Nov 24; 4(11):e7983. Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN. PMID: 19956695; PMCID: PMC2776992.
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    173. Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. J Immunol. 2009 Nov 15; 183(10):6313-9. Tagen M, Elorza A, Kempuraj D, Boucher W, Kepley CL, Shirihai OS, Theoharides TC. PMID: 19846869; PMCID: PMC2925218.
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    174. Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics. EMBO J. 2009 Oct 21; 28(20):3074-89. Liu X, Weaver D, Shirihai O, Hajnóczky G. PMID: 19745815; PMCID: PMC2771091.
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    175. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16263-8. Chen W, Paradkar PN, Li L, Pierce EL, Langer NB, Takahashi-Makise N, Hyde BB, Shirihai OS, Ward DM, Kaplan J, Paw BH. PMID: 19805291; PMCID: PMC2752562.
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    176. The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets. Obesity (Silver Spring). 2009 Oct; 17(10):1856-60. Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE. PMID: 19644453; PMCID: PMC3808997.
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    177. Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009 Oct; 58(10):2303-15. Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS. PMID: 19581419; PMCID: PMC2750232.
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    178. What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy? Int J Biochem Cell Biol. 2009 Oct; 41(10):1914-27. Wikstrom JD, Twig G, Shirihai OS. PMID: 19549572.
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    179. Frequency and selectivity of mitochondrial fusion are key to its quality maintenance function. Biophys J. 2009 May 06; 96(9):3509-18. Mouli PK, Twig G, Shirihai OS. PMID: 19413957; PMCID: PMC2711405.
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    180. Monitoring mitochondrial dynamics with photoactivatable [corrected] green fluorescent protein. Methods Enzymol. 2009; 457:289-304. Molina AJ, Shirihai OS. PMID: 19426874; PMCID: PMC5967387.
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    181. UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008 Nov 07; 283(45):30461-70. Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS. PMID: 18687678; PMCID: PMC2576537.
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    182. Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta. 2008 Sep; 1777(9):1092-7. Twig G, Hyde B, Shirihai OS. PMID: 18519024; PMCID: PMC3809017.
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    183. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. PMID: 18223655; PMCID: PMC3918232.
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    184. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 23; 27(2):433-46. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. PMID: 18200046; PMCID: PMC2234339.
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    185. beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 2007 Oct; 56(10):2569-78. Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS. PMID: 17686943.
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    186. Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 2007 Apr 01; 403(1):197-205. Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE. PMID: 17181533; PMCID: PMC1828901.
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    187. Direct interorganellar transfer of iron from endosome to mitochondrion. Blood. 2007 Jul 01; 110(1):125-32. Sheftel AD, Zhang AS, Brown C, Shirihai OS, Ponka P. PMID: 17376890.
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    188. PA-GFP: a window into the subcellular adventures of the individual mitochondrion. Novartis Found Symp. 2007; 287:21-36; discussion 36-46. Haigh SE, Twig G, Molina AA, Wikstrom JD, Deutsch M, Shirihai OS. PMID: 18074629.
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    189. A novel miniature cell retainer for correlative high-content analysis of individual untethered non-adherent cells. Lab Chip. 2006 Aug; 6(8):995-1000. Deutsch M, Deutsch A, Shirihai O, Hurevich I, Afrimzon E, Shafran Y, Zurgil N. PMID: 16874368.
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    190. Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP. Am J Physiol Cell Physiol. 2006 Jul; 291(1):C176-84. Twig G, Graf SA, Wikstrom JD, Mohamed H, Haigh SE, Elorza A, Deutsch M, Zurgil N, Reynolds N, Shirihai OS. PMID: 16481372.
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    191. Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells. Am J Physiol Endocrinol Metab. 2006 Jan; 290(1):E143-E148. Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE. PMID: 16144817.
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    192. Synergistic amplification of beta-amyloid- and interferon-gamma-induced microglial neurotoxic response by the senile plaque component chromogranin A. Am J Physiol Cell Physiol. 2005 Jan; 288(1):C169-75. Twig G, Graf SA, Messerli MA, Smith PJ, Yoo SH, Shirihai OS. PMID: 15342341.
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    193. Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). J Biol Chem. 2004 Oct 08; 279(41):42954-63. Graf SA, Haigh SE, Corson ED, Shirihai OS. PMID: 15215243.
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    194. SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell. 2002 Oct; 10(4):843-55. Best JL, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, Meluh PB, Pandolfi PP, Zon LI. PMID: 12419228.
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