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PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity. Proc Natl Acad Sci U S A. 2024 Dec 03; 121(49):e2416882121.
Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Bhatia V, Han M, Abt ER, Park JW, Memarzadeh S, Shackelford DB, Lee JK, Graeber TG, Shirihai OS, Witte ON. PMID: 39589879.
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PubMed Mentions:
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Universal high-throughput image quantification of subcellular structure dynamics and spatial distributions within cells. bioRxiv. 2024 Oct 22.
Martin A, Zhang S, Williamson A, Tingley B, Pickus M, Zurakowski D, Nia HT, Shirihai O, Han X, Grinstaff MW. PMID: 39229224; PMCID: PMC11370428.
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PubMed Mentions:
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A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction. Cell Rep Med. 2024 Oct 17; 101795.
Li S, Tao B, Wan J, Montecino-Rodriguez E, Wang P, Ma F, Sun B, Gu Y, Ramadoss S, Su L, Sun Q, Hoeve JT, Stiles L, Collins J, van Dam RM, Tamboline M, Taschereau R, Shirihai O, Kitchen DB, Pellegrini M, Graeber T, Dorshkind K, Xu S, Deb A. PMID: 39454569.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Mfn2 induces NCLX-mediated calcium release from mitochondria. bioRxiv. 2024 Aug 13.
Kolitsida P, Saha A, Caliri A, Assali E, Riera AM, Itskanov S, Magana CS, Stork B, Shirihai O, Sekler I, Koehler CM, van der Bliek AM. PMID: 39149365; PMCID: PMC11326197.
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PubMed Mentions:
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PGC-1α drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity. bioRxiv. 2024 Jul 25.
Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Bhatia V, Han M, Abt ER, Park JW, Memarzadeh S, Shackelford D, Lee JK, Graeber T, Shirihai O, Witte O. PMID: 38645232; PMCID: PMC11030384.
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NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis. Mol Metab. 2024 Sep; 87:101982.
Taha M, Assali EA, Ben-Kasus Nissim T, Stutzmann GE, Shirihai OS, Hershfinkel M, Sekler I. PMID: 38960129; PMCID: PMC11325370.
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Translation:
AnimalsCells
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Acidic Nanoparticles Restore Lysosomal Acidification and Rescue Metabolic Dysfunction in Pancreatic β-Cells under Lipotoxic Conditions. ACS Nano. 2024 Jun 18; 18(24):15452-15467.
Lo CH, O'Connor LM, Loi GWZ, Saipuljumri EN, Indajang J, Lopes KM, Shirihai OS, Grinstaff MW, Zeng J. PMID: 38830624; PMCID: PMC11192035.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respiration. bioRxiv. 2024 May 14.
Ball AB, Jones AE, Nguy?n KB, Rios A, Marx N, Hsieh WY, Yang K, Desousa BR, Kim KKO, Veliova M, Del Mundo ZM, Shirihai OS, Benincá C, Stiles L, Bensinger SJ, Divakaruni AS. PMID: 38798678; PMCID: PMC11118427.
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PubMed Mentions:
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Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria. Sci Adv. 2024 Apr 05; 10(14):eadl0389.
Zhou Z, Ma A, Moore TM, Wolf DM, Yang N, Tran P, Segawa M, Strumwasser AR, Ren W, Fu K, Wanagat J, van der Bliek AM, Crosbie-Watson R, Liesa M, Stiles L, Acin-Perez R, Mahata S, Shirihai O, Goodarzi MO, Handzlik M, Metallo CM, Walker DW, Hevener AL. PMID: 38569044; PMCID: PMC10990287.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Role of the mitochondrial protein cyclophilin D in skin wound healing and collagen secretion. JCI Insight. 2024 Apr 02; 9(9).
Bansal R, Torres M, Hunt M, Wang N, Chatzopoulou M, Manchanda M, Taddeo EP, Shu C, Shirihai OS, Bachar-Wikstrom E, Wikstrom JD. PMID: 38564292; PMCID: PMC11141914.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Impaired AMPK Control of Alveolar Epithelial Cell Metabolism Promotes Pulmonary Fibrosis. bioRxiv. 2024 Mar 28.
Rodriguez LR, Alysandratos KD, Katzen J, Murthy A, Barboza WR, Tomer Y, Acin-Perez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF. PMID: 38585863; PMCID: PMC10996612.
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PubMed Mentions:
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A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity. Res Sq. 2024 Mar 22.
Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood M, Boldrini M, Thiebaut de Schotten M, Picard M. PMID: 38562777; PMCID: PMC10984021.
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PubMed Mentions:
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A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity. bioRxiv. 2024 Mar 07.
Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood M, Boldrini M, de Schotten MT, Picard M. PMID: 38496679; PMCID: PMC10942385.
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PubMed Mentions:
1
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Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2. bioRxiv. 2024 Feb 28.
Wortham M, Ramms B, Zeng C, Benthuysen JR, Sai S, Pollow DP, Liu F, Schlichting M, Harrington AR, Liu B, Prakash TP, Pirie EC, Zhu H, Baghdasarian S, Auwerx J, Shirihai OS, Sander M. PMID: 38464227; PMCID: PMC10925077.
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PubMed Mentions:
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The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. J Biol Chem. 2024 Mar; 300(3):105702.
Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. PMID: 38301896; PMCID: PMC10910128.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis. Redox Biol. 2024 04; 70:103052.
Gutierrez V, Kim-Vasquez D, Shum M, Yang Q, Dikeman D, Louie SG, Shirihai OS, Tsukamoto H, Liesa M. PMID: 38290384; PMCID: PMC10844117.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma. Cancer Res. 2024 01 16; 84(2):305-327.
Saggese P, Pandey A, Alcaraz M, Fung E, Hall A, Yanagawa J, Rodriguez EF, Grogan TR, Giurato G, Nassa G, Salvati A, Shirihai OS, Weisz A, Dubinett SM, Scafoglio C. PMID: 37934116; PMCID: PMC10790128.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Mitochondria isolated from lipid droplets of white adipose tissue reveal functional differences based on lipid droplet size. Life Sci Alliance. 2024 02; 7(2).
Brownstein AJ, Veliova M, Acin-Perez R, Villalobos F, Petcherski A, Tombolato A, Liesa M, Shirihai OS. PMID: 38056907; PMCID: PMC10700548.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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A ketogenic diet can mitigate SARS-CoV-2 induced systemic reprogramming and inflammation. Commun Biol. 2023 11 03; 6(1):1115.
Palermo A, Li S, Ten Hoeve J, Chellappa A, Morris A, Dillon B, Ma F, Wang Y, Cao E, Shabane B, Acín-Perez R, Petcherski A, Lusis AJ, Hazen S, Shirihai OS, Pellegrini M, Arumugaswami V, Graeber TG, Deb A. PMID: 37923961; PMCID: PMC10624922.
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PubMed Mentions:
1 Translation:
AnimalsCells
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Regulation of Postnatal Cardiomyocyte Maturation by an RNA Splicing Regulator RBFox1. Circulation. 2023 10 17; 148(16):1263-1266.
Huang J, Lee JZ, Rau CD, Pezhouman A, Yokota T, Miwa H, Feldman M, Kong TK, Yang Z, Tay WT, Pushkarsky I, Kim K, Parikh SS, Udani S, Soh BS, Gao C, Stiles L, Shirihai OS, Knollmann BC, Ardehali R, Di Carlo D, Wang Y. PMID: 37844148; PMCID: PMC10593507.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer. Cell Rep. 2023 10 31; 42(10):113221.
Crowell PD, Giafaglione JM, Jones AE, Nunley NM, Hashimoto T, Delcourt AML, Petcherski A, Agrawal R, Bernard MJ, Diaz JA, Heering KY, Huang RR, Low JY, Matulionis N, Navone NM, Ye H, Zoubeidi A, Christofk HR, Rettig MB, Reiter RE, Haffner MC, Boutros PC, Shirihai OS, Divakaruni AS, Goldstein AS. PMID: 37815914.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. bioRxiv. 2023 Aug 16.
Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. PMID: 37645724; PMCID: PMC10461965.
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Calculation of ATP production rates using the Seahorse XF Analyzer. EMBO Rep. 2023 10 09; 24(10):e56380.
Desousa BR, Kim KK, Jones AE, Ball AB, Hsieh WY, Swain P, Morrow DH, Brownstein AJ, Ferrick DA, Shirihai OS, Neilson A, Nathanson DA, Rogers GW, Dranka BP, Murphy AN, Affourtit C, Bensinger SJ, Stiles L, Romero N, Divakaruni AS. PMID: 37548091; PMCID: PMC10561364.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. Nat Commun. 2023 05 04; 14(1):2573.
Zeng J, Acin-Perez R, Assali EA, Martin A, Brownstein AJ, Petcherski A, Fernández-Del-Rio L, Xiao R, Lo CH, Shum M, Liesa M, Han X, Shirihai OS, Grinstaff MW. PMID: 37142604; PMCID: PMC10160018.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Nutrient regulation of the islet epigenome controls adaptive insulin secretion. J Clin Invest. 2023 04 17; 133(8).
Wortham M, Liu F, Harrington AR, Fleischman JY, Wallace M, Mulas F, Mallick M, Vinckier NK, Cross BR, Chiou J, Patel NA, Sui Y, McGrail C, Jun Y, Wang G, Jhala US, Schüle R, Shirihai OS, Huising MO, Gaulton KJ, Metallo CM, Sander M. PMID: 36821378; PMCID: PMC10104905.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Nature. 2023 03; 615(7953):712-719.
Han M, Bushong EA, Segawa M, Tiard A, Wong A, Brady MR, Momcilovic M, Wolf DM, Zhang R, Petcherski A, Madany M, Xu S, Lee JT, Poyurovsky MV, Olszewski K, Holloway T, Gomez A, John MS, Dubinett SM, Koehler CM, Shirihai OS, Stiles L, Lisberg A, Soatto S, Sadeghi S, Ellisman MH, Shackelford DB. PMID: 36922590; PMCID: PMC10033418.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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A novel approach to measure complex V ATP hydrolysis in frozen cell lysates and tissue homogenates. Life Sci Alliance. 2023 04; 6(4).
Fernandez-Del-Rio L, Benincá C, Villalobos F, Shu C, Stiles L, Liesa M, Divakaruni AS, Acin-Perez R, Shirihai OS. PMID: 36918278; PMCID: PMC10019470.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA. EMBO J. 2023 06 01; 42(11):e111901.
Ngo J, Choi DW, Stanley IA, Stiles L, Molina AJA, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, Miller N, Baghdasarian S, Kim-Vasquez D, Jones AE, Roach B, Gutierrez V, Erion K, Divakaruni AS, Liesa M, Danial NN, Shirihai OS. PMID: 36917141; PMCID: PMC10233380.
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PubMed Mentions:
35 Fields:
Translation:
Cells
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Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies. EMBO J. 2023 05 15; 42(10):e111699.
Acin-Perez R, Benincá C, Fernandez Del Rio L, Shu C, Baghdasarian S, Zanette V, Gerle C, Jiko C, Khairallah R, Khan S, Rincon Fernandez Pacheco D, Shabane B, Erion K, Masand R, Dugar S, Ghenoiu C, Schreiner G, Stiles L, Liesa M, Shirihai OS. PMID: 36912136; PMCID: PMC10183817.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Blood immune cells from people with HIV on antiviral regimens that contain tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) have differential metabolic signatures. Metabolism. 2023 04; 141:155395.
Ritou E, Satta S, Petcherski A, Daskou M, Sharma M, Vasilopoulos H, Murakami E, Shirihai OS, Kelesidis T. PMID: 36842771; PMCID: PMC10932727.
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HumansCellsCTClinical Trials
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Measuring Mitochondrial Uncoupling in Mouse Primary Brown Adipocytes Differentiated Ex Vivo. Methods Mol Biol. 2023; 2662:53-65.
Veliova M, Tol MJ, Tontonoz P, Shirihai OS, Liesa M. PMID: 37076670.
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AnimalsCells
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Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas. Nat Commun. 2022 11 17; 13(1):7037.
Do Rhee K, Wang Y, Ten Hoeve J, Stiles L, Nguyen TTT, Zhang X, Vergnes L, Reue K, Shirihai O, Bok D, Yang XJ. PMID: 36396639; PMCID: PMC9672129.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes. Nat Commun. 2022 11 04; 13(1):6661.
Moore TM, Cheng L, Wolf DM, Ngo J, Segawa M, Zhu X, Strumwasser AR, Cao Y, Clifford BL, Ma A, Scumpia P, Shirihai OS, Vallim TQA, Laakso M, Lusis AJ, Hevener AL, Zhou Z. PMID: 36333379; PMCID: PMC9636263.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial signal transduction. Cell Metab. 2022 11 01; 34(11):1620-1653.
Picard M, Shirihai OS. PMID: 36323233; PMCID: PMC9692202.
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PubMed Mentions:
123 Fields:
Translation:
HumansCells
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The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR. Mol Metab. 2022 10; 64:101566.
Steffen J, Ngo J, Wang SP, Williams K, Kramer HF, Ho G, Rodriguez C, Yekkala K, Amuzie C, Bialecki R, Norquay L, Nawrocki AR, Erion M, Pocai A, Shirihai OS, Liesa M. PMID: 35940556; PMCID: PMC9420962.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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TNFα-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice. Brain Sci. 2022 Jul 09; 12(7).
Desai M, Stiles L, Torsoni AS, Torsoni MA, Shirihai OS, Ross MG. PMID: 35884707; PMCID: PMC9316209.
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PubMed Mentions:
2
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Mitoquinone mesylate targets SARS-CoV-2 infection in preclinical models. bioRxiv. 2022 Jun 23.
Petcherski A, Sharma M, Daskou M, Satta S, Vasilopoulos H, Hugo C, Ritou E, Dillon BJ, Fung E, Garcia G, Scafoglio C, Purkayastha A, Gomperts BN, Fishbein GA, Arumugaswami V, Liesa M, Shirihai OS, Kelesidis T. PMID: 35233569; PMCID: PMC8887067.
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PubMed Mentions:
1
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The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells. Virulence. 2021 12; 12(1):2214-2227.
Kelesidis T, Madhav S, Petcherski A, Cristelle H, O'Connor E, Hultgren NW, Ritou E, Williams DS, Shirihai OS, Reddy ST. PMID: 34494942; PMCID: PMC8437485.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance. Mol Metab. 2022 01; 55:101403.
Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M. PMID: 34823065; PMCID: PMC8689243.
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AnimalsCells
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DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer. Commun Biol. 2021 11 16; 4(1):1289.
Shen N, Korm S, Karantanos T, Li D, Zhang X, Ritou E, Xu H, Lam A, English J, Zong WX, Liu CT, Shirihai O, Feng H. PMID: 34785772; PMCID: PMC8595664.
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PubMed Mentions:
23 Translation:
HumansCells
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ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity. Rev Endocr Metab Disord. 2022 02; 23(1):121-131.
Brownstein AJ, Veliova M, Acin-Perez R, Liesa M, Shirihai OS. PMID: 34741717; PMCID: PMC8873062.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Mitochondrial Heterogeneity in Metabolic Diseases. Biology (Basel). 2021 Sep 17; 10(9).
Ngo J, Osto C, Villalobos F, Shirihai OS. PMID: 34571805; PMCID: PMC8470264.
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PubMed Mentions:
11
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Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives. Life (Basel). 2021 Sep 10; 11(9).
Acin-Perez R, Benincá C, Shabane B, Shirihai OS, Stiles L. PMID: 34575097; PMCID: PMC8467772.
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PubMed Mentions:
10
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Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Rep. 2021 08 31; 36(9):109636.
Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. PMID: 34469722; PMCID: PMC8432578.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Recruitment and remodeling of peridroplet mitochondria in human adipose tissue. Redox Biol. 2021 10; 46:102087.
Acín-Perez R, Petcherski A, Veliova M, Benador IY, Assali EA, Colleluori G, Cinti S, Brownstein AJ, Baghdasarian S, Livhits MJ, Yeh MW, Krishnan KC, Vergnes L, Winn NC, Padilla J, Liesa M, Sacks HS, Shirihai OS. PMID: 34411987; PMCID: PMC8377484.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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IRGM1 links mitochondrial quality control to autoimmunity. Nat Immunol. 2021 03; 22(3):312-321.
Rai P, Janardhan KS, Meacham J, Madenspacher JH, Lin WC, Karmaus PWF, Martinez J, Li QZ, Yan M, Zeng J, Grinstaff MW, Shirihai OS, Taylor GA, Fessler MB. PMID: 33510463; PMCID: PMC7906953.
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PubMed Mentions:
49 Fields:
Translation:
AnimalsCells
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High-Throughput Image Analysis of Lipid-Droplet-Bound Mitochondria. Methods Mol Biol. 2021; 2276:285-303.
Miller N, Wolf D, Alsabeeh N, Mahdaviani K, Segawa M, Liesa M, Shirihai OS. PMID: 34060050.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Isolation and functional analysis of peridroplet mitochondria from murine brown adipose tissue. STAR Protoc. 2021 03 19; 2(1):100243.
Ngo J, Benador IY, Brownstein AJ, Vergnes L, Veliova M, Shum M, Acín-Pérez R, Reue K, Shirihai OS, Liesa M. PMID: 33458705; PMCID: PMC7797917.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling. EMBO Rep. 2020 12 03; 21(12):e49634.
Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein AJ, Desousa BR, Acín-Pérez R, Petcherski A, Assali EA, Stiles L, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, Shirihai OS. PMID: 33275313; PMCID: PMC7726774.
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PubMed Mentions:
17 Fields:
Translation:
Cells
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Mitochondrial oxidative function in NAFLD: Friend or foe? Mol Metab. 2021 08; 50:101134.
Shum M, Ngo J, Shirihai OS, Liesa M. PMID: 33276146; PMCID: PMC8324685.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Measuring Mitochondrial Respiration in Previously Frozen Biological Samples. Curr Protoc Cell Biol. 2020 12; 89(1):e116.
Osto C, Benador IY, Ngo J, Liesa M, Stiles L, Acin-Perez R, Shirihai OS. PMID: 33320426.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Modulating lysosomal pH: a molecular and nanoscale materials design perspective. J Life Sci (Westlake Village). 2020 Dec; 2(4):25-37.
Zeng J, Shirihai OS, Grinstaff MW. PMID: 33403369; PMCID: PMC7781074.
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PubMed Mentions:
28
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Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics. Front Cell Dev Biol. 2020; 8:592035.
Gonzalez-Ibanez AM, Ruiz LM, Jensen E, Echeverria CA, Romero V, Stiles L, Shirihai OS, Elorza AA. PMID: 33330472; PMCID: PMC7719720.
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PubMed Mentions:
15
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Forces, fluxes, and fuels: tracking mitochondrial metabolism by integrating measurements of membrane potential, respiration, and metabolites. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C80-C91.
Jones AE, Sheng L, Acevedo A, Veliova M, Shirihai OS, Stiles L, Divakaruni AS. PMID: 33147057; PMCID: PMC7846976.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity. Nat Metab. 2020 09; 2(9):974-988.
Acín-Pérez R, Iborra S, Martí-Mateos Y, Cook ECL, Conde-Garrosa R, Petcherski A, Muñoz MDM, Martínez de Mena R, Krishnan KC, Jiménez C, Bolaños JP, Laakso M, Lusis AJ, Shirihai OS, Sancho D, Enríquez JA. PMID: 32943786; PMCID: PMC8225238.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Ellagic Acid and Its Microbial Metabolite Urolithin A Alleviate Diet-Induced Insulin Resistance in Mice. Mol Nutr Food Res. 2020 10; 64(19):e2000091.
Yang J, Guo Y, Henning SM, Chan B, Long J, Zhong J, Acin-Perez R, Petcherski A, Shirihai O, Heber D, Li Z. PMID: 32783299; PMCID: PMC9185853.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake. Redox Biol. 2020 10; 37:101676.
Cerqueira FM, von Stockum S, Giacomello M, Goliand I, Kakimoto P, Marchesan E, De Stefani D, Kowaltowski AJ, Ziviani E, Shirihai OS. PMID: 32956978; PMCID: PMC7509235.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Sci Transl Med. 2020 08 05; 12(555).
Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. PMID: 32759275; PMCID: PMC8212422.
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PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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NCLX prevents cell death during adrenergic activation of the brown adipose tissue. Nat Commun. 2020 07 03; 11(1):3347.
Assali EA, Jones AE, Veliova M, Acín-Pérez R, Taha M, Miller N, Shum M, Oliveira MF, Las G, Liesa M, Sekler I, Shirihai OS. PMID: 32620768; PMCID: PMC7334226.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Reply to: In vivo quantification of mitochondrial membrane potential. Nature. 2020 07; 583(7815):E19-E20.
Momcilovic M, Shirihai O, Murphy MP, Koehler CM, Sadeghi S, Shackelford DB. PMID: 32641810.
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PubMed Mentions: Fields:
Translation:
Cells
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Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria. Life Sci Alliance. 2020 07; 3(7).
Segawa M, Wolf DM, Hultgren NW, Williams DS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. PMID: 32499316; PMCID: PMC7283135.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO J. 2020 07 01; 39(13):e104073.
Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. PMID: 32432379; PMCID: PMC7327496.
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PubMed Mentions:
85 Fields:
Translation:
AnimalsCells
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The biology of lipid droplet-bound mitochondria. Semin Cell Dev Biol. 2020 12; 108:55-64.
Veliova M, Petcherski A, Liesa M, Shirihai OS. PMID: 32446655; PMCID: PMC8019155.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10. J Biol Chem. 2020 05 01; 295(18):6023-6042.
Bradley MC, Yang K, Fernández-Del-Río L, Ngo J, Ayer A, Tsui HS, Novales NA, Stocker R, Shirihai OS, Barros MH, Clarke CF. PMID: 32205446; PMCID: PMC7196636.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Method for live-cell super-resolution imaging of mitochondrial cristae and quantification of submitochondrial membrane potentials. Methods Cell Biol. 2020; 155:545-555.
Wolf DM, Segawa M, Shirihai OS, Liesa M. PMID: 32183976; PMCID: PMC7216778.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner. EMBO Rep. 2020 03 04; 21(3):e49776.
Kondadi AK, Anand R, Hänsch S, Urbach J, Zobel T, Wolf DM, Segawa M, Liesa M, Shirihai OS, Weidtkamp-Peters S, Reichert AS. PMID: 32067344; PMCID: PMC7054676.
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PubMed Mentions:
66 Fields:
Translation:
HumansCells
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MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy. Biochem J. 2020 01 31; 477(2):461-475.
Cerqueira FM, Kozer N, Petcherski A, Baranovski BM, Wolf D, Assali EA, Roth Y, Gazit R, Barr H, Lewis EC, Las G, Shirihai OS. PMID: 32003437.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Emerging roles of β-cell mitochondria in type-2-diabetes. Mol Aspects Med. 2020 02; 71:100843.
Las G, Oliveira MF, Shirihai OS. PMID: 31918997.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2020 01; 577(7791):E7.
Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31896820.
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PubMed Mentions: Fields:
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Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels. Diabetes. 2020 02; 69(2):131-145.
Taddeo EP, Alsabeeh N, Baghdasarian S, Wikstrom JD, Ritou E, Sereda S, Erion K, Li J, Stiles L, Abdulla M, Swanson Z, Wilhelm JJ, Bellin MD, Kibbey RG, Liesa M, Shirihai OS. PMID: 31740442; PMCID: PMC6971491.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2019 Nov; 575(7783):E5.
Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N. PMID: 31695192.
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PubMed Mentions:
1 Fields:
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In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019 11; 575(7782):380-384.
Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31666695; PMCID: PMC7328016.
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PubMed Mentions:
91 Fields:
Translation:
HumansAnimalsCells
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Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. EMBO J. 2019 11 15; 38(22):e101056.
Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. PMID: 31609012; PMCID: PMC6856616.
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PubMed Mentions:
135 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial morphology regulates organellar Ca2+ uptake and changes cellular Ca2+ homeostasis. FASEB J. 2019 12; 33(12):13176-13188.
Kowaltowski AJ, Menezes-Filho SL, Assali EA, Gonçalves IG, Cabral-Costa JV, Abreu P, Miller N, Nolasco P, Laurindo FRM, Bruni-Cardoso A, Shirihai OS. PMID: 31480917; PMCID: PMC9272750.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Publisher Correction: IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function. Nat Commun. 2019 Jul 31; 10(1):3507.
Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. PMID: 31366929; PMCID: PMC6668385.
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PubMed Mentions:
3 Fields:
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Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos. Cell Rep. 2019 07 16; 28(3):759-772.e10.
Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG. PMID: 31315053; PMCID: PMC6713209.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Biodegradable PLGA nanoparticles restore lysosomal acidity and protect neural PC-12 cells against mitochondrial toxicity. Ind Eng Chem Res. 2019 Aug 07; 58(31):13910-13917.
Zeng J, Martin A, Han X, Shirihai OS, Grinstaff MW. PMID: 38576774; PMCID: PMC10993316.
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PubMed Mentions:
26
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IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function. Nat Commun. 2019 06 18; 10(1):2679.
Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. PMID: 31213603; PMCID: PMC6581914.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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To Fis or not to Fuse? This is the question! EMBO J. 2019 04 15; 38(8).
Liesa M, Van der Bliek A, Shirihai OS. PMID: 30936092; PMCID: PMC6463207.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization. Cell Metab. 2019 04 02; 29(4):827-835.
Benador IY, Veliova M, Liesa M, Shirihai OS. PMID: 30905670; PMCID: PMC6476311.
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PubMed Mentions:
115 Fields:
Translation:
HumansAnimalsCells
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A Thermogenic-Like Brown Adipose Tissue Phenotype Is Dispensable for Enhanced Glucose Tolerance in Female Mice. Diabetes. 2019 09; 68(9):1717-1729.
Winn NC, Acin-Perez R, Woodford ML, Hansen SA, Haney MM, Ayedun LA, Rector RS, Vieira-Potter VJ, Shirihai OS, Sacks HS, Kanaley JA, Padilla J. PMID: 30862679; PMCID: PMC6702635.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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The OXPHOS supercomplex assembly factor HIG2A responds to changes in energetic metabolism and cell cycle. J Cell Physiol. 2019 08; 234(10):17405-17419.
Salazar C, Elorza AA, Cofre G, Ruiz-Hincapie P, Shirihai O, Ruiz LM. PMID: 30779122.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Degradable Nanoparticles Restore Lysosomal pH and Autophagic Flux in Lipotoxic Pancreatic Beta Cells. Adv Healthc Mater. 2019 06; 8(12):e1801511.
Zeng J, Shirihai OS, Grinstaff MW. PMID: 30698920.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in β cells under lipotoxicity. FASEB J. 2019 03; 33(3):4154-4165.
Assali EA, Shlomo D, Zeng J, Taddeo EP, Trudeau KM, Erion KA, Colby AH, Grinstaff MW, Liesa M, Las G, Shirihai OS. PMID: 30550357; PMCID: PMC8793810.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Mol Metab. 2019 03; 21:51-67.
Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL. PMID: 30591411; PMCID: PMC6407367.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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Individual islet respirometry reveals functional diversity within the islet population of mice and human donors. Mol Metab. 2018 10; 16:150-159.
Taddeo EP, Stiles L, Sereda S, Ritou E, Wolf DM, Abdullah M, Swanson Z, Wilhelm J, Bellin M, McDonald P, Caradonna K, Neilson A, Liesa M, Shirihai OS. PMID: 30098928; PMCID: PMC6157638.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling. iScience. 2018 Jul 27; 5:99-109.
Waters LR, Ahsan FM, Wolf DM, Shirihai O, Teitell MA. PMID: 30240649; PMCID: PMC6123864.
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PubMed Mentions:
133
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A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer Metab. 2018; 6:7.
Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. PMID: 29988332; PMCID: PMC6022704.
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PubMed Mentions:
15
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Mitochondrial adaptation in obesity is a ClpPicated business. EMBO Rep. 2018 06; 19(6).
Liesa M, Shirihai OS. PMID: 29789387; PMCID: PMC5989752.
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HumansCells
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Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency. EMBO J. 2018 05 15; 37(10).
Rodríguez-Nuevo A, Díaz-Ramos A, Noguera E, Díaz-Sáez F, Duran X, Muñoz JP, Romero M, Plana N, Sebastián D, Tezze C, Romanello V, Ribas F, Seco J, Planet E, Doctrow SR, González J, Borràs M, Liesa M, Palacín M, Vendrell J, Villarroya F, Sandri M, Shirihai O, Zorzano A. PMID: 29632021; PMCID: PMC5978453.
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PubMed Mentions:
101 Fields:
Translation:
AnimalsCells
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Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion. Cell Metab. 2018 04 03; 27(4):869-885.e6.
Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF, Cinti S, Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE, Liesa M, Shirihai OS. PMID: 29617645; PMCID: PMC5969538.
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PubMed Mentions:
234 Fields:
Translation:
AnimalsCells
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Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. J Biol Chem. 2018 03 30; 293(13):4735-4751.
Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. PMID: 29378845; PMCID: PMC5880140.
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PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
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Cell culture models of fatty acid overload: Problems and solutions. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Feb; 1863(2):143-151.
Alsabeeh N, Chausse B, Kakimoto PA, Kowaltowski AJ, Shirihai O. PMID: 29155055; PMCID: PMC5969525.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimals
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Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line. Cell Cycle. 2017; 16(21):2086-2099.
Montemurro C, Vadrevu S, Gurlo T, Butler AE, Vongbunyong KE, Petcherski A, Shirihai OS, Satin LS, Braas D, Butler PC, Tudzarova S. PMID: 28820316; PMCID: PMC5731404.
View in:
PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):E5167-E5176.
Tkatch T, Greotti E, Baranauskas G, Pendin D, Roy S, Nita LI, Wettmarshausen J, Prigge M, Yizhar O, Shirihai OS, Fishman D, Hershfinkel M, Fleidervish IA, Perocchi F, Pozzan T, Sekler I. PMID: 28611221; PMCID: PMC5495261.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 07; 18(7):1123-1138.
Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. PMID: 28539390; PMCID: PMC5887905.
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PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
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Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation. Cell Metab. 2017 May 02; 25(5):1160-1175.e11.
Zeng C, Mulas F, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, Sander M. PMID: 28467932; PMCID: PMC5501713.
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PubMed Mentions:
84 Fields:
Translation:
HumansAnimalsCells
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Modulation of mTOR signaling as a strategy for the treatment of Pompe disease. EMBO Mol Med. 2017 03; 9(3):353-370.
Lim JA, Li L, Shirihai OS, Trudeau KM, Puertollano R, Raben N. PMID: 28130275; PMCID: PMC5331267.
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PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
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LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016 11 17; 539(7629):390-395.
Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N. PMID: 27799657; PMCID: PMC5988435.
View in:
PubMed Mentions:
166 Fields:
Translation:
HumansAnimalsCells
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Proteinuria causes dysfunctional autophagy in the proximal tubule. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1271-F1279.
Nolin AC, Mulhern RM, Panchenko MV, Pisarek-Horowitz A, Wang Z, Shirihai O, Borkan SC, Havasi A. PMID: 27582098; PMCID: PMC5210197.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity. J Cell Biol. 2016 07 04; 214(1):25-34.
Trudeau KM, Colby AH, Zeng J, Las G, Feng JH, Grinstaff MW, Shirihai OS. PMID: 27377248; PMCID: PMC4932370.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Mitochondrial Networking in T Cell Memory. Cell. 2016 Jun 30; 166(1):9-10.
Liesa M, Shirihai OS. PMID: 27368094.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Nanoparticle tumor localization, disruption of autophagosomal trafficking, and prolonged drug delivery improve survival in peritoneal mesothelioma. Biomaterials. 2016 09; 102:175-86.
Liu R, Colby AH, Gilmore D, Schulz M, Zeng J, Padera RF, Shirihai O, Grinstaff MW, Colson YL. PMID: 27343465; PMCID: PMC4948582.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Cellular Star Trek: A laser-based shuttle transfers mitochondria into cells. Mol Metab. 2016 Oct; 5(10):805-806.
Las G, Shirihai O. PMID: 27688994; PMCID: PMC5034483.
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PubMed Mentions: Fields:
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BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell. PLoS One. 2016; 11(3):e0151329.
Deeney JT, Belkina AC, Shirihai OS, Corkey BE, Denis GV. PMID: 27008626; PMCID: PMC4805167.
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PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
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Diluted serum from calorie-restricted animals promotes mitochondrial β-cell adaptations and protect against glucolipotoxicity. FEBS J. 2016 Mar; 283(5):822-33.
Cerqueira FM, Chausse B, Baranovski BM, Liesa M, Lewis EC, Shirihai OS, Kowaltowski AJ. PMID: 26732506.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling. Atherosclerosis. 2016 04; 247:207-17.
Fetterman JL, Holbrook M, Flint N, Feng B, Bretón-Romero R, Linder EA, Berk BD, Duess MA, Farb MG, Gokce N, Shirihai OS, Hamburg NM, Vita JA. PMID: 26926601; PMCID: PMC4913892.
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PubMed Mentions:
52 Fields:
Translation:
HumansCells
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Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease. J Am Heart Assoc. 2016 Jan 11; 5(1).
Sverdlov AL, Elezaby A, Qin F, Behring JB, Luptak I, Calamaras TD, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Bachschmid MM, Colucci WS. PMID: 26755553; PMCID: PMC4859372.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222.
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, et al. PMID: 26799652; PMCID: PMC4835977.
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PubMed Mentions:
2829 Fields:
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HumansAnimals
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Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics. Stem Cells. 2016 Mar; 34(3):743-55.
Forni MF, Peloggia J, Trudeau K, Shirihai O, Kowaltowski AJ. PMID: 26638184; PMCID: PMC4803524.
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PubMed Mentions:
107 Fields:
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AnimalsCells
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Assessment of Brown Adipocyte Thermogenic Function by High-throughput Respirometry. Bio Protoc. 2015 Nov 05; 5(21).
Mahdaviani K, Benador I, Shirihai O. PMID: 29770346; PMCID: PMC5951411.
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PubMed Mentions:
1
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Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes. Metabolism. 2016 Jan; 65(1):26-35.
Mahdaviani K, Chess D, Wu Y, Shirihai O, Aprahamian TR. PMID: 26683794; PMCID: PMC4684900.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle. Cell Metab. 2015 Nov 03; 22(5):936-47.
Alves TC, Pongratz RL, Zhao X, Yarborough O, Sereda S, Shirihai O, Cline GW, Mason G, Kibbey RG. PMID: 26411341; PMCID: PMC4635072.
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PubMed Mentions:
71 Fields:
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AnimalsCells
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Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. J Clin Invest. 2015 Oct 01; 125(10):3847-60.
Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE. PMID: 26389676; PMCID: PMC4607115.
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PubMed Mentions:
102 Fields:
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HumansAnimalsCells
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Mutations in LRRK2 potentiate age-related impairment of autophagic flux. Mol Neurodegener. 2015 Jul 11; 10:26.
Saha S, Ash PE, Gowda V, Liu L, Shirihai O, Wolozin B. PMID: 26159606; PMCID: PMC4702340.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione. PLoS One. 2015; 10(6):e0129772.
Qiu W, Liesa M, Carpenter EP, Shirihai OS. PMID: 26053025; PMCID: PMC4459825.
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PubMed Mentions:
6 Fields:
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HumansAnimalsCells
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How mitochondrial dynamism orchestrates mitophagy. Circ Res. 2015 May 22; 116(11):1835-49.
Shirihai OS, Song M, Dorn GW. PMID: 25999423; PMCID: PMC4443843.
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PubMed Mentions:
138 Fields:
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HumansAnimalsCells
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Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2015 May; 7(5):688.
Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R. PMID: 25940533; PMCID: PMC4492824.
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PubMed Mentions:
7 Fields:
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A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity. Nat Commun. 2015 Apr 28; 6:7014.
Qiao S, Dennis M, Song X, Vadysirisack DD, Salunke D, Nash Z, Yang Z, Liesa M, Yoshioka J, Matsuzawa S, Shirihai OS, Lee RT, Reed JC, Ellisen LW. PMID: 25916556; PMCID: PMC4421852.
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PubMed Mentions:
95 Fields:
Translation:
AnimalsCells
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Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 2015 May 12; 4(5):873-85.
Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN. PMID: 25843048; PMCID: PMC4437473.
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PubMed Mentions:
45 Fields:
Translation:
HumansCells
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Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. J Mol Cell Cardiol. 2015 Feb; 79:275-83.
Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Colucci WS, Miller EJ. PMID: 25497302; PMCID: PMC4301992.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2014 Nov; 6(11):1493-507.
Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R. PMID: 25319546; PMCID: PMC4237473.
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PubMed Mentions:
51 Fields:
Translation:
AnimalsCells
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High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II. J Mol Cell Cardiol. 2015 Jan; 78:165-73.
Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS. PMID: 25109264; PMCID: PMC4268348.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Miro1: new wheels for transferring mitochondria. EMBO J. 2014 May 02; 33(9):939-41.
Las G, Shirihai OS. PMID: 24711517; PMCID: PMC4193928.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus. Vasc Med. 2014 Feb; 19(1):67-74.
Hartman ML, Shirihai OS, Holbrook M, Xu G, Kocherla M, Shah A, Fetterman JL, Kluge MA, Frame AA, Hamburg NM, Vita JA. PMID: 24558030; PMCID: PMC3932629.
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PubMed Mentions:
61 Fields:
Translation:
HumansCells
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Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure. EMBO J. 2014 Mar 03; 33(5):418-36.
Wikstrom JD, Mahdaviani K, Liesa M, Sereda SB, Si Y, Las G, Twig G, Petrovic N, Zingaretti C, Graham A, Cinti S, Corkey BE, Cannon B, Nedergaard J, Shirihai OS. PMID: 24431221; PMCID: PMC3983686.
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PubMed Mentions:
141 Fields:
Translation:
AnimalsCells
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Measurement of mitochondrial turnover and life cycle using MitoTimer. Methods Enzymol. 2014; 547:21-38.
Trudeau KM, Gottlieb RA, Shirihai OS. PMID: 25416350.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity. Mitochondrion. 2013 Nov; 13(6):662-7.
Nickens KP, Wikstrom JD, Shirihai OS, Patierno SR, Ceryak S. PMID: 24075934; PMCID: PMC3837383.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age. Autophagy. 2013 Nov 01; 9(11):1887-96.
Ferree AW, Trudeau K, Zik E, Benador IY, Twig G, Gottlieb RA, Shirihai OS. PMID: 24149000; PMCID: PMC4028338.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Optimal dynamics for quality control in spatially distributed mitochondrial networks. PLoS Comput Biol. 2013; 9(7):e1003108.
Patel PK, Shirihai O, Huang KC. PMID: 23874166; PMCID: PMC3708874.
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PubMed Mentions:
26 Fields:
Translation:
Cells
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Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. Sci Transl Med. 2013 Jul 03; 5(192):192ra85.
Kalghatgi S, Spina CS, Costello JC, Liesa M, Morones-Ramirez JR, Slomovic S, Molina A, Shirihai OS, Collins JJ. PMID: 23825301; PMCID: PMC3760005.
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PubMed Mentions:
204 Fields:
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HumansAnimalsCells
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ATP-binding cassette B10 regulates early steps of heme synthesis. Circ Res. 2013 Jul 19; 113(3):279-87.
Bayeva M, Khechaduri A, Wu R, Burke MA, Wasserstrom JA, Singh N, Liesa M, Shirihai OS, Langer NB, Paw BH, Ardehali H. PMID: 23720443; PMCID: PMC3817742.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab. 2013 Apr 02; 17(4):491-506.
Liesa M, Shirihai OS. PMID: 23562075; PMCID: PMC5967396.
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PubMed Mentions:
598 Fields:
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HumansAnimalsCells
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Mitochondrial morphology transitions and functions: implications for retrograde signaling? Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15; 304(6):R393-406.
Picard M, Shirihai OS, Gentil BJ, Burelle Y. PMID: 23364527; PMCID: PMC3602821.
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PubMed Mentions:
135 Fields:
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HumansAnimalsCells
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Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in male mice. PLoS One. 2012; 7(12):e51180.
Guo W, Wong S, Li M, Liang W, Liesa M, Serra C, Jasuja R, Bartke A, Kirkland JL, Shirihai O, Bhasin S. PMID: 23240002; PMCID: PMC3519841.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Association of genetic variation in the mitochondrial genome with blood pressure and metabolic traits. Hypertension. 2012 Oct; 60(4):949-56.
Liu C, Yang Q, Hwang SJ, Sun F, Johnson AD, Shirihai OS, Vasan RS, Levy D, Schwartz F. PMID: 22949535; PMCID: PMC3753106.
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PubMed Mentions:
26 Fields:
Translation:
Humans
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Metabolic master regulators: sharing information among multiple systems. Trends Endocrinol Metab. 2012 Dec; 23(12):594-601.
Corkey BE, Shirihai O. PMID: 22939743; PMCID: PMC3502692.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Mitochondrial ABC transporters function: the role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species. Biochim Biophys Acta. 2012 Oct; 1823(10):1945-57.
Liesa M, Qiu W, Shirihai OS. PMID: 22884976; PMCID: PMC3808996.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial dynamics and morphology in beta-cells. Best Pract Res Clin Endocrinol Metab. 2012 Dec; 26(6):725-38.
Stiles L, Shirihai OS. PMID: 23168275; PMCID: PMC5967392.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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A faster, high resolution, mtPA-GFP-based mitochondrial fusion assay acquiring kinetic data of multiple cells in parallel using confocal microscopy. J Vis Exp. 2012 Jul 20; (65):e3991.
Lovy A, Molina AJ, Cerqueira FM, Trudeau K, Shirihai OS. PMID: 22847388; PMCID: PMC3476419.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Mol Cell Biol. 2012 Aug; 32(16):3333-46.
Blättler SM, Verdeguer F, Liesa M, Cunningham JT, Vogel RO, Chim H, Liu H, Romanino K, Shirihai OS, Vazquez F, Rüegg MA, Shi Y, Puigserver P. PMID: 22711985; PMCID: PMC3434543.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. PLoS One. 2012; 7(5):e33023.
Wikstrom JD, Sereda SB, Stiles L, Elorza A, Allister EM, Neilson A, Ferrick DA, Wheeler MB, Shirihai OS. PMID: 22606219; PMCID: PMC3351473.
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PubMed Mentions:
71 Fields:
Translation:
HumansAnimalsCells
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Mitochondria distinguish granule-stored from de novo synthesized tumor necrosis factor secretion in human mast cells. Int Arch Allergy Immunol. 2012; 159(1):23-32.
Zhang B, Weng Z, Sismanopoulos N, Asadi S, Therianou A, Alysandratos KD, Angelidou A, Shirihai O, Theoharides TC. PMID: 22555146; PMCID: PMC4278585.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544.
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, et al. PMID: 22966490; PMCID: PMC3404883.
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PubMed Mentions:
1819 Fields:
Translation:
HumansAnimals
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Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 2012 Feb 17; 148(4):651-63.
Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA. PMID: 22341440; PMCID: PMC3286017.
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PubMed Mentions:
167 Fields:
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HumansAnimalsCells
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Role of mitofusin 2 in the renal stress response. PLoS One. 2012; 7(1):e31074.
Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG. PMID: 22292091; PMCID: PMC3266928.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. PLoS One. 2012; 7(1):e30200.
Saadeh M, Ferrante TC, Kane A, Shirihai O, Corkey BE, Deeney JT. PMID: 22272304; PMCID: PMC3260220.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Mitochondrial dynamics: the intersection of form and function. Adv Exp Med Biol. 2012; 748:13-40.
Ferree A, Shirihai O. PMID: 22729853; PMCID: PMC5967395.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Hum Mol Genet. 2012 Mar 01; 21(5):978-90.
Gilkerson RW, De Vries RL, Lebot P, Wikstrom JD, Torgyekes E, Shirihai OS, Przedborski S, Schon EA. PMID: 22080835; PMCID: PMC3277306.
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PubMed Mentions:
88 Fields:
Translation:
HumansCells
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Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Diabetes. 2011 Nov; 60(11):2710-9.
Robson-Doucette CA, Sultan S, Allister EM, Wikstrom JD, Koshkin V, Bhattacharjee A, Prentice KJ, Sereda SB, Shirihai OS, Wheeler MB. PMID: 21984579; PMCID: PMC3198081.
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65 Fields:
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HumansAnimalsCells
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Fatty acids suppress autophagic turnover in β-cells. J Biol Chem. 2011 Dec 09; 286(49):42534-42544.
Las G, Serada SB, Wikstrom JD, Twig G, Shirihai OS. PMID: 21859708; PMCID: PMC3234912.
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PubMed Mentions:
108 Fields:
Translation:
AnimalsCells
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Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16; 124(7):806-13.
Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS. PMID: 21788586; PMCID: PMC4491919.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation. 2011 Jul 26; 124(4):444-53.
Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE, Hamburg NM, Frame AA, Caiano TL, Kluge MA, Duess MA, Levit A, Kim B, Hartman ML, Joseph L, Shirihai OS, Vita JA. PMID: 21747057; PMCID: PMC3149100.
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PubMed Mentions:
281 Fields:
Translation:
HumansCells
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The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell. 2011 Jul 01; 22(13):2235-45.
Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song WJ, Sereda S, Clerc P, Polster BM, Aja SM, Pletnikov MV, Kensler TW, Shirihai OS, Iijima M, Hussain MA, Sesaki H. PMID: 21551073; PMCID: PMC3128526.
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PubMed Mentions:
87 Fields:
Translation:
AnimalsCells
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The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal. 2011 May 15; 14(10):1939-51.
Twig G, Shirihai OS. PMID: 21128700; PMCID: PMC3078508.
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PubMed Mentions:
376 Fields:
Translation:
HumansAnimalsCells
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Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011 Apr 01; 25(7):717-29.
Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC. PMID: 21406549; PMCID: PMC3070934.
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PubMed Mentions:
781 Fields:
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HumansAnimalsCells
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Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011 Feb 17; 470(7334):359-65.
Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. PMID: 21307849; PMCID: PMC3741661.
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PubMed Mentions:
647 Fields:
Translation:
AnimalsCells
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The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature. 2010 Dec 02; 468(7324):659-63.
Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N. PMID: 21124451; PMCID: PMC3037591.
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PubMed Mentions:
224 Fields:
Translation:
AnimalsCells
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Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C477-87.
Twig G, Liu X, Liesa M, Wikstrom JD, Molina AJ, Las G, Yaniv G, Hajnóczky G, Shirihai OS. PMID: 20445168; PMCID: PMC2928626.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 2010 Jan 22; 140(2):280-93.
Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. PMID: 20141841; PMCID: PMC2821045.
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PubMed Mentions:
526 Fields:
Translation:
AnimalsCells
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Organellar vs cellular control of mitochondrial dynamics. Semin Cell Dev Biol. 2010 Aug; 21(6):575-81.
Hyde BB, Twig G, Shirihai OS. PMID: 20079451; PMCID: PMC3808978.
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PubMed Mentions:
38 Fields:
Translation:
Cells
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Respiration in adipocytes is inhibited by reactive oxygen species. Obesity (Silver Spring). 2010 Aug; 18(8):1493-502.
Wang T, Si Y, Shirihai OS, Si H, Schultz V, Corkey RF, Hu L, Deeney JT, Guo W, Corkey BE. PMID: 20035277; PMCID: PMC6154476.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One. 2009 Nov 24; 4(11):e7983.
Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN. PMID: 19956695; PMCID: PMC2776992.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. J Immunol. 2009 Nov 15; 183(10):6313-9.
Tagen M, Elorza A, Kempuraj D, Boucher W, Kepley CL, Shirihai OS, Theoharides TC. PMID: 19846869; PMCID: PMC2925218.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics. EMBO J. 2009 Oct 21; 28(20):3074-89.
Liu X, Weaver D, Shirihai O, Hajnóczky G. PMID: 19745815; PMCID: PMC2771091.
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PubMed Mentions:
186 Fields:
Translation:
AnimalsCells
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Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16263-8.
Chen W, Paradkar PN, Li L, Pierce EL, Langer NB, Takahashi-Makise N, Hyde BB, Shirihai OS, Ward DM, Kaplan J, Paw BH. PMID: 19805291; PMCID: PMC2752562.
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PubMed Mentions:
117 Fields:
Translation:
AnimalsCells
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The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets. Obesity (Silver Spring). 2009 Oct; 17(10):1856-60.
Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE. PMID: 19644453; PMCID: PMC3808997.
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PubMed Mentions:
19 Fields:
Translation:
Animals
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Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009 Oct; 58(10):2303-15.
Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS. PMID: 19581419; PMCID: PMC2750232.
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PubMed Mentions:
212 Fields:
Translation:
HumansAnimalsCells
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What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy? Int J Biochem Cell Biol. 2009 Oct; 41(10):1914-27.
Wikstrom JD, Twig G, Shirihai OS. PMID: 19549572.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Frequency and selectivity of mitochondrial fusion are key to its quality maintenance function. Biophys J. 2009 May 06; 96(9):3509-18.
Mouli PK, Twig G, Shirihai OS. PMID: 19413957; PMCID: PMC2711405.
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PubMed Mentions:
77 Fields:
Translation:
AnimalsCells
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Monitoring mitochondrial dynamics with photoactivatable [corrected] green fluorescent protein. Methods Enzymol. 2009; 457:289-304.
Molina AJ, Shirihai OS. PMID: 19426874; PMCID: PMC5967387.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008 Nov 07; 283(45):30461-70.
Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS. PMID: 18687678; PMCID: PMC2576537.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta. 2008 Sep; 1777(9):1092-7.
Twig G, Hyde B, Shirihai OS. PMID: 18519024; PMCID: PMC3809017.
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PubMed Mentions:
315 Fields:
Translation:
HumansAnimalsCells
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Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53.
Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. PMID: 18223655; PMCID: PMC3918232.
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144 Fields:
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HumansAnimalsCells
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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 23; 27(2):433-46.
Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. PMID: 18200046; PMCID: PMC2234339.
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PubMed Mentions:
1501 Fields:
Translation:
AnimalsCells
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beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 2007 Oct; 56(10):2569-78.
Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS. PMID: 17686943.
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PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
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Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 2007 Apr 01; 403(1):197-205.
Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE. PMID: 17181533; PMCID: PMC1828901.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Direct interorganellar transfer of iron from endosome to mitochondrion. Blood. 2007 Jul 01; 110(1):125-32.
Sheftel AD, Zhang AS, Brown C, Shirihai OS, Ponka P. PMID: 17376890.
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PubMed Mentions:
116 Fields:
Translation:
AnimalsCells
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PA-GFP: a window into the subcellular adventures of the individual mitochondrion. Novartis Found Symp. 2007; 287:21-36; discussion 36-46.
Haigh SE, Twig G, Molina AA, Wikstrom JD, Deutsch M, Shirihai OS. PMID: 18074629.
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PubMed Mentions:
4 Fields:
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HumansAnimalsCells
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A novel miniature cell retainer for correlative high-content analysis of individual untethered non-adherent cells. Lab Chip. 2006 Aug; 6(8):995-1000.
Deutsch M, Deutsch A, Shirihai O, Hurevich I, Afrimzon E, Shafran Y, Zurgil N. PMID: 16874368.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP. Am J Physiol Cell Physiol. 2006 Jul; 291(1):C176-84.
Twig G, Graf SA, Wikstrom JD, Mohamed H, Haigh SE, Elorza A, Deutsch M, Zurgil N, Reynolds N, Shirihai OS. PMID: 16481372.
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PubMed Mentions:
63 Fields:
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HumansAnimalsCells
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Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells. Am J Physiol Endocrinol Metab. 2006 Jan; 290(1):E143-E148.
Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE. PMID: 16144817.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Synergistic amplification of beta-amyloid- and interferon-gamma-induced microglial neurotoxic response by the senile plaque component chromogranin A. Am J Physiol Cell Physiol. 2005 Jan; 288(1):C169-75.
Twig G, Graf SA, Messerli MA, Smith PJ, Yoo SH, Shirihai OS. PMID: 15342341.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). J Biol Chem. 2004 Oct 08; 279(41):42954-63.
Graf SA, Haigh SE, Corson ED, Shirihai OS. PMID: 15215243.
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PubMed Mentions:
32 Fields:
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HumansAnimalsCells
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SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell. 2002 Oct; 10(4):843-55.
Best JL, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, Meluh PB, Pandolfi PP, Zon LI. PMID: 12419228.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells