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Characterization of a Bioactive Peptide T14 in the Human and Rodent Substantia Nigra: Implications for Neurodegenerative Disease. Int J Mol Sci. 2022 Oct 28; 23(21).
Greenfield SA, Ferrati G, Coen CW, Vadisiute A, Molnár Z, Garcia-Rates S, Frautschy S, Cole GM. PMID: 36361905; PMCID: PMC9654939.
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1 Fields:
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HumansAnimals
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Editorial: Role of Inflammation in Neurodegenerative Diseases. Front Immunol. 2022; 13:958487.
Koronyo-Hamaoui M, Gaire BP, Frautschy SA, Alvarez JI. PMID: 35799792; PMCID: PMC9253757.
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2 Fields:
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Humans
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A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential. Alzheimers Dement (N Y). 2022; 8(1):e12274.
Greenfield SA, Cole GM, Coen CW, Frautschy S, Singh RP, Mekkittikul M, Garcia-Ratés S, Morrill P, Hollings O, Passmore M, Hasan S, Carty N, Bison S, Piccoli L, Carletti R, Tacconi S, Chalidou A, Pedercini M, Kroecher T, Astner H, Gerrard PA. PMID: 35415206; PMCID: PMC8983808.
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5
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Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study. Cells. 2021 10 28; 10(11).
Dumitrascu OM, Rosenberry R, Sherman DS, Khansari MM, Sheyn J, Torbati T, Sherzai A, Sherzai D, Johnson KO, Czeszynski AD, Verdooner S, Black KL, Frautschy S, Lyden PD, Shi Y, Cheng S, Koronyo Y, Koronyo-Hamaoui M. PMID: 34831149; PMCID: PMC8616417.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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CR3 ruffles FcγR's claim over phagocytic cups. J Biol Chem. 2021 Jan-Jun; 296:100801.
Frautschy SA. PMID: 34019878; PMCID: PMC8191298.
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AnimalsCells
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Editorial: Oxidative Stress in Myocardial and Neural Remodeling. Front Physiol. 2021; 12:606484.
Nguyen TP, Frautschy SA, Eghbali M. PMID: 33613307; PMCID: PMC7893088.
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The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models. Front Immunol. 2020; 11:558036.
Ma QL, Zhu C, Morselli M, Su T, Pelligrini M, Lu Z, Jones M, Denver P, Castro D, Gu X, Relampagos F, Caoili K, Teter B, Frautschy SA, Cole GM. PMID: 33178186; PMCID: PMC7596305.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline. Alzheimers Dement (Amst). 2020; 12(1):e12109.
Dumitrascu OM, Lyden PD, Torbati T, Sheyn J, Sherzai A, Sherzai D, Sherman DS, Rosenberry R, Cheng S, Johnson KO, Czeszynski AD, Verdooner S, Frautschy S, Black KL, Koronyo Y, Koronyo-Hamaoui M. PMID: 33015311; PMCID: PMC7521595.
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19
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Modeling Mixed Vascular and Alzheimer's Dementia Using Focal Subcortical Ischemic Stroke in Human ApoE4-TR:5XFAD Transgenic Mice. Transl Stroke Res. 2020 10; 11(5):1064-1076.
Hayden EY, Huang JM, Charreton M, Nunez SM, Putman JN, Teter B, Lee JT, Welch A, Frautschy S, Cole G, Teng E, Hinman JD. PMID: 32086779; PMCID: PMC10075511.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples. Anal Biochem. 2020 05 01; 596:113636.
Yoon AJ, Wu H, Pan RD, Teter B, Cipolla J, Chang E, Avila LZ, Basak SK, Srivatsan ES, Wang MB, Cole GM, Frautschy SA, Hampton PD, Faull KF. PMID: 32081619.
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HumansAnimalsCells
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A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer's Disease. Front Physiol. 2019; 10:1269.
Denver P, D'Adamo H, Hu S, Zuo X, Zhu C, Okuma C, Kim P, Castro D, Jones MR, Leal C, Mekkittikul M, Ghadishah E, Teter B, Vinters HV, Cole GM, Frautschy SA. PMID: 31708792; PMCID: PMC6821690.
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PubMed Mentions:
12
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Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis. Neurobiol Dis. 2019 07; 127:432-448.
Teter B, Morihara T, Lim GP, Chu T, Jones MR, Zuo X, Paul RM, Frautschy SA, Cole GM. PMID: 30951849; PMCID: PMC8092921.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease. Neurobiol Dis. 2018 06; 114:120-128.
Ma QL, Teng E, Zuo X, Jones M, Teter B, Zhao EY, Zhu C, Bilousova T, Gylys KH, Apostolova LG, LaDu MJ, Hossain MA, Frautschy SA, Cole GM. PMID: 29501530; PMCID: PMC8092920.
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PubMed Mentions:
14 Fields:
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HumansAnimalsCells
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Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease. JCI Insight. 2017 Aug 17; 2(16).
Koronyo Y, Biggs D, Barron E, Boyer DS, Pearlman JA, Au WJ, Kile SJ, Blanco A, Fuchs DT, Ashfaq A, Frautschy S, Cole GM, Miller CA, Hinton DR, Verdooner SR, Black KL, Koronyo-Hamaoui M. PMID: 28814675; PMCID: PMC5621887.
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203 Fields:
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Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer's Disease. J Alzheimers Dis. 2017; 60(4):1429-1442.
Sundaram JR, Poore CP, Sulaimee NHB, Pareek T, Cheong WF, Wenk MR, Pant HC, Frautschy SA, Low CM, Kesavapany S. PMID: 29036814; PMCID: PMC8092919.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain. Neuroreport. 2016 08 03; 27(11):791-5.
Teter B, LaDu MJ, Sullivan PM, Frautschy SA, Cole GM. PMID: 27281274; PMCID: PMC5042345.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization. Neurobiol Dis. 2015 Oct; 82:552-560.
Teng E, Taylor K, Bilousova T, Weiland D, Pham T, Zuo X, Yang F, Chen PP, Glabe CG, Takacs A, Hoffman DR, Frautschy SA, Cole GM. PMID: 26369878; PMCID: PMC4641021.
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18 Fields:
Translation:
HumansAnimalsCells
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Clinical development of curcumin in neurodegenerative disease. Expert Rev Neurother. 2015 Jun; 15(6):629-37.
Hu S, Maiti P, Ma Q, Zuo X, Jones MR, Cole GM, Frautschy SA. PMID: 26035622; PMCID: PMC6800094.
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PubMed Mentions:
61 Fields:
Translation:
Humans
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Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015 Apr; 14(4):388-405.
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. PMID: 25792098; PMCID: PMC5909703.
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Parallel age-associated changes in brain and plasma neuronal pentraxin receptor levels in a transgenic APP/PS1 rat model of Alzheimer's disease. Neurobiol Dis. 2015 Feb; 74:32-40.
Bilousova T, Taylor K, Emirzian A, Gylys R, Frautschy SA, Cole GM, Teng E. PMID: 25449907; PMCID: PMC4323940.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin. Biomed Res Int. 2014; 2014:495091.
Maiti P, Manna J, Veleri S, Frautschy S. PMID: 25386560; PMCID: PMC4217372.
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PubMed Mentions:
42 Fields:
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HumansCells
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Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. J Neurosci. 2014 May 21; 34(21):7124-36.
Ma QL, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M, Kiosea NC, Nazari S, Chen PP, Nothias F, Chan P, Teng E, Frautschy SA, Cole GM. PMID: 24849348; PMCID: PMC4028492.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. J Biol Chem. 2013 Feb 08; 288(6):4056-65.
Ma QL, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M, Teng E, Hu S, Chen PP, Maiti P, Teter B, Cole GM, Frautschy SA. PMID: 23264626; PMCID: PMC3567657.
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PubMed Mentions:
74 Fields:
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HumansAnimalsCells
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Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012 Dec; 135(Pt 12):3735-48.
Attar A, Ripoli C, Riccardi E, Maiti P, Li Puma DD, Liu T, Hayes J, Jones MR, Lichti-Kaiser K, Yang F, Gale GD, Tseng CH, Tan M, Xie CW, Straudinger JL, Klärner FG, Schrader T, Frautschy SA, Grassi C, Bitan G. PMID: 23183235; PMCID: PMC3525056.
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PubMed Mentions:
43 Fields:
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AnimalsCells
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C-terminal turn stability determines assembly differences between Aβ40 and Aβ42. J Mol Biol. 2013 Jan 23; 425(2):292-308.
Roychaudhuri R, Yang M, Deshpande A, Cole GM, Frautschy S, Lomakin A, Benedek GB, Teplow DB. PMID: 23154165; PMCID: PMC3540122.
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PubMed Mentions:
35 Fields:
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AnimalsCells
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Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res Ther. 2012; 4(5):43.
Ringman JM, Frautschy SA, Teng E, Begum AN, Bardens J, Beigi M, Gylys KH, Badmaev V, Heath DD, Apostolova LG, Porter V, Vanek Z, Marshall GA, Hellemann G, Sugar C, Masterman DL, Montine TJ, Cummings JL, Cole GM. PMID: 23107780; PMCID: PMC3580400.
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PubMed Mentions:
155 Fields:
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Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease. Mol Neurodegener. 2012 Apr 04; 7:12.
Hickey MA, Zhu C, Medvedeva V, Lerner RP, Patassini S, Franich NR, Maiti P, Frautschy SA, Zeitlin S, Levine MS, Chesselet MF. PMID: 22475209; PMCID: PMC3348060.
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PubMed Mentions:
49 Fields:
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AnimalsCells
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PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. Cell Logist. 2012 Apr 01; 2(2):117-125.
Ma QL, Yang F, Frautschy SA, Cole GM. PMID: 23162743; PMCID: PMC3490962.
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PubMed Mentions:
41
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Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1. Pharmacol Biochem Behav. 2012 Mar; 101(1):125-31.
Borbon IA, Hillman Z, Duran E, Kiela PR, Frautschy SA, Erickson RP. PMID: 22202649; PMCID: PMC3466425.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment. Neurobiol Dis. 2011 Sep; 43(3):565-75.
Teng E, Kepe V, Frautschy SA, Liu J, Satyamurthy N, Yang F, Chen PP, Cole GB, Jones MR, Huang SC, Flood DG, Trusko SP, Small GW, Cole GM, Barrio JR. PMID: 21605674; PMCID: PMC3144750.
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PubMed Mentions:
21 Fields:
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HumansAnimalsCells
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What was lost in translation in the DHA trial is whom you should intend to treat. Alzheimers Res Ther. 2011 Jan 20; 3(1):2.
Frautschy SA, Cole GM. PMID: 21251328; PMCID: PMC3109411.
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8 Fields:
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Dietary fatty acids and the aging brain. Nutr Rev. 2010 Dec; 68 Suppl 2:S102-11.
Cole GM, Ma QL, Frautschy SA. PMID: 21091943; PMCID: PMC4019000.
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PubMed Mentions:
28 Fields:
Translation:
Humans
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Why pleiotropic interventions are needed for Alzheimer's disease. Mol Neurobiol. 2010 Jun; 41(2-3):392-409.
Frautschy SA, Cole GM. PMID: 20437209; PMCID: PMC2876259.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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Mechanisms of action of non-steroidal anti-inflammatory drugs for the prevention of Alzheimer's disease. CNS Neurol Disord Drug Targets. 2010 Apr; 9(2):140-8.
Cole GM, Frautschy SA. PMID: 20205646; PMCID: PMC4312283.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimals
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Thinking outside the box about COX-1 in Alzheimer's disease. Neurobiol Dis. 2010 Jun; 38(3):492-4.
Frautschy SA. PMID: 20206264; PMCID: PMC4313739.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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DHA may prevent age-related dementia. J Nutr. 2010 Apr; 140(4):869-74.
Cole GM, Frautschy SA. PMID: 20181786; PMCID: PMC2838628.
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PubMed Mentions:
40 Fields:
Translation:
Humans
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Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behavior. Behav Brain Res. 2010 Mar 05; 207(2):305-9.
Ramanathan L, Hu S, Frautschy SA, Siegel JM. PMID: 19850085; PMCID: PMC2815069.
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PubMed Mentions:
29 Fields:
Translation:
Animals
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Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci. 2009 Jul 15; 29(28):9078-89.
Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM. PMID: 19605645; PMCID: PMC3849615.
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PubMed Mentions:
208 Fields:
Translation:
HumansAnimalsCells
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Omega-3 fatty acids and dementia. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep; 81(2-3):213-21.
Cole GM, Ma QL, Frautschy SA. PMID: 19523795; PMCID: PMC4019002.
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PubMed Mentions:
71 Fields:
Translation:
HumansAnimals
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Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid. Arch Neurol. 2009 Apr; 66(4):448-57.
Ma QL, Galasko DR, Ringman JM, Vinters HV, Edland SD, Pomakian J, Ubeda OJ, Rosario ER, Teter B, Frautschy SA, Cole GM. PMID: 19364929; PMCID: PMC2742778.
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PubMed Mentions:
43 Fields:
Translation:
HumansCells
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Use of copper and insulin-resistance to accelerate cognitive deficits and synaptic protein loss in a rat Abeta-infusion Alzheimer's disease model. J Alzheimers Dis. 2008 Dec; 15(4):625-40.
Begum AN, Yang F, Teng E, Hu S, Jones MR, Rosario ER, Beech W, Hudspeth B, Ubeda OJ, Cole GM, Frautschy SA. PMID: 19096161; PMCID: PMC4313743.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals. Neurobiol Dis. 2009 Feb; 33(2):193-206.
Hu S, Begum AN, Jones MR, Oh MS, Beech WK, Beech BH, Yang F, Chen P, Ubeda OJ, Kim PC, Davies P, Ma Q, Cole GM, Frautschy SA. PMID: 19038340; PMCID: PMC4313761.
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PubMed Mentions:
69 Fields:
Translation:
AnimalsCells
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Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus. Brain Res. 2009 Jan 16; 1249:191-201.
Hu S, Ying Z, Gomez-Pinilla F, Frautschy SA. PMID: 19014914; PMCID: PMC3307371.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp Ther. 2008 Jul; 326(1):196-208.
Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA. PMID: 18417733; PMCID: PMC2527621.
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PubMed Mentions:
217 Fields:
Translation:
Animals
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p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. J Biol Chem. 2008 May 16; 283(20):14132-43.
Ma QL, Yang F, Calon F, Ubeda OJ, Hansen JE, Weisbart RH, Beech W, Frautschy SA, Cole GM. PMID: 18347024; PMCID: PMC2376243.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain. 2008 Mar; 131(Pt 3):651-64.
Kotilinek LA, Westerman MA, Wang Q, Panizzon K, Lim GP, Simonyi A, Lesne S, Falinska A, Younkin LH, Younkin SG, Rowan M, Cleary J, Wallis RA, Sun GY, Cole G, Frautschy S, Anwyl R, Ashe KH. PMID: 18292081; PMCID: PMC2628581.
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PubMed Mentions:
98 Fields:
Translation:
AnimalsCells
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Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention. J Neurosci. 2007 Dec 26; 27(52):14299-307.
Ma QL, Teter B, Ubeda OJ, Morihara T, Dhoot D, Nyby MD, Tuck ML, Frautschy SA, Cole GM. PMID: 18160637; PMCID: PMC2628584.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models. J Neurochem. 2007 Nov; 103(4):1594-607.
Ma QL, Harris-White ME, Ubeda OJ, Simmons M, Beech W, Lim GP, Teter B, Frautschy SA, Cole GM. PMID: 17760871; PMCID: PMC2527620.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Neuroprotective effects of curcumin. Adv Exp Med Biol. 2007; 595:197-212.
Cole GM, Teter B, Frautschy SA. PMID: 17569212; PMCID: PMC2527619.
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PubMed Mentions:
145 Fields:
Translation:
HumansAnimals
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The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease. Exp Gerontol. 2007 Jan-Feb; 42(1-2):10-21.
Cole GM, Frautschy SA. PMID: 17049785.
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PubMed Mentions:
75 Fields:
Translation:
HumansCells
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Commentary on "Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery." Pleiotropic approaches to Alzheimer's and other diseases of aging. Alzheimers Dement. 2006 Oct; 2(4):284-6.
Cole GM, Frautschy SA. PMID: 19595901.
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PubMed Mentions:
1 Fields:
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Cat and mouse. Neuron. 2006 Sep 21; 51(6):671-2.
Cole GM, Frautschy SA. PMID: 16982408.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Alzheimer's amyloid story finds its star. Trends Mol Med. 2006 Sep; 12(9):395-6.
Cole GM, Frautschy SA. PMID: 16880006.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits. Proc Natl Acad Sci U S A. 2006 Jun 06; 103(23):8852-7.
Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen TK, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J, Koistinaho J. PMID: 16723396; PMCID: PMC1482667.
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PubMed Mentions:
21 Fields:
Translation:
Animals
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Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J Neurosci Res. 2006 Feb 15; 83(3):374-84.
Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM. PMID: 16385556.
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PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
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Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci. 2006 Feb; 9(2):234-42.
Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM. PMID: 16415866.
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PubMed Mentions:
159 Fields:
Translation:
HumansAnimalsCells
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Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model. Nutr Health. 2006; 18(3):249-59.
Cole GM, Frautschy SA. PMID: 17180870.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions. Neurobiol Aging. 2005 Dec; 26 Suppl 1:133-6.
Cole GM, Lim GP, Yang F, Teter B, Begum A, Ma Q, Harris-White ME, Frautschy SA. PMID: 16266772.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimals
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Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition. Curr Drug Targets CNS Neurol Disord. 2005 Oct; 4(5):469-80.
Harris-White ME, Frautschy SA. PMID: 16266282.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Tetrahydrocurcumin in plasma and urine: quantitation by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25; 824(1-2):206-12.
Heath DD, Pruitt MA, Brenner DE, Begum AN, Frautschy SA, Rock CL. PMID: 16061427.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. Eur J Neurosci. 2005 Aug; 22(3):617-26.
Calon F, Lim GP, Morihara T, Yang F, Ubeda O, Salem N, Frautschy SA, Cole GM. PMID: 16101743.
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PubMed Mentions:
76 Fields:
Translation:
HumansAnimals
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Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models. Neuropsychopharmacology. 2005 Jun; 30(6):1111-20.
Morihara T, Teter B, Yang F, Lim GP, Boudinot S, Boudinot FD, Frautschy SA, Cole GM. PMID: 15688088.
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PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
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Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro. J Neurochem. 2005 May; 93(4):1038-46.
Xie Z, Harris-White ME, Wals PA, Frautschy SA, Finch CE, Morgan TE. PMID: 15857407.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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A potential role of the curry spice curcumin in Alzheimer's disease. Curr Alzheimer Res. 2005 Apr; 2(2):131-6.
Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL. PMID: 15974909; PMCID: PMC1702408.
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PubMed Mentions:
129 Fields:
Translation:
HumansAnimals
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A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci. 2005 Mar 23; 25(12):3032-40.
Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N, Frautschy SA, Cole GM. PMID: 15788759; PMCID: PMC6725084.
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PubMed Mentions:
217 Fields:
Translation:
Animals
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Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. J Neurosci. 2004 Dec 08; 24(49):11120-6.
Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM. PMID: 15590928; PMCID: PMC6730264.
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PubMed Mentions:
131 Fields:
Translation:
HumansAnimalsCells
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Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18; 280(7):5892-901.
Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. PMID: 15590663.
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PubMed Mentions:
628 Fields:
Translation:
HumansAnimalsCells
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NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models. Ann N Y Acad Sci. 2004 Dec; 1035:68-84.
Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA. PMID: 15681801.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo. Neurobiol Aging. 2004 Nov-Dec; 25(10):1283-92.
Craft JM, Watterson DM, Frautschy SA, Van Eldik LJ. PMID: 15465624.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron. 2004 Sep 02; 43(5):633-45.
Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N, Ashe KH, Frautschy SA, Cole GM. PMID: 15339646; PMCID: PMC2442162.
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PubMed Mentions:
212 Fields:
Translation:
HumansAnimalsCells
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Role of LRP in TGFbeta2-mediated neuronal uptake of Abeta and effects on memory. J Neurosci Res. 2004 Jul 15; 77(2):217-28.
Harris-White ME, Balverde Z, Lim GP, Kim P, Miller SA, Hammer H, Galasko D, Frautschy SA. PMID: 15211588.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines. Neurobiol Aging. 2002 Mar-Apr; 23(2):195-203.
Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Tanemura K, Frautschy SA, Takashima A. PMID: 11804703.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 01; 21(21):8370-7.
Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. PMID: 11606625; PMCID: PMC6762797.
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PubMed Mentions:
406 Fields:
Translation:
AnimalsCells
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Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging. 2001 Nov-Dec; 22(6):983-91.
Lim GP, Yang F, Chu T, Gahtan E, Ubeda O, Beech W, Overmier JB, Hsiao-Ashec K, Frautschy SA, Cole GM. PMID: 11755007.
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PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
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Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging. 2001 Nov-Dec; 22(6):993-1005.
Frautschy SA, Hu W, Kim P, Miller SA, Chu T, Harris-White ME, Cole GM. PMID: 11755008.
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PubMed Mentions:
149 Fields:
Translation:
Cells
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Church baptizes Joseph and Perry. Eccentric views absolved. Neurobiol Aging. 2001 Jan-Feb; 22(1):147-50; discussion 161-3.
Cole GM, Frautschy SA. PMID: 11164288.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci. 2000 Aug 01; 20(15):5709-14.
Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, Cole GM. PMID: 10908610; PMCID: PMC6772529.
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PubMed Mentions:
288 Fields:
Translation:
AnimalsCells
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Inflammation and Alzheimer's disease. Neurobiol Aging. 2000 May-Jun; 21(3):383-421.
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T. PMID: 10858586; PMCID: PMC3887148.
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PubMed Mentions:
1584 Fields:
Translation:
Humans
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Mapping biochemistry to metabolism: FDG-PET and amyloid burden in Alzheimer's disease. Neuroreport. 1999 Sep 29; 10(14):2911-7.
Mega MS, Chu T, Mazziotta JC, Trivedi KH, Thompson PM, Shah A, Cole G, Frautschy SA, Toga AW. PMID: 10549796.
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PubMed Mentions:
11 Fields:
Translation:
HumansPHPublic Health
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Lipoprotein effects on Abeta accumulation and degradation by microglia in vitro. J Neurosci Res. 1999 Aug 15; 57(4):504-20.
Cole GM, Beech W, Frautschy SA, Sigel J, Glasgow C, Ard MD. PMID: 10440900.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures. Neuroscience. 1999; 91(3):1009-16.
Teter B, Harris-White ME, Frautschy SA, Cole GM. PMID: 10391478.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Neuroprotection with Bcl-2(20-34) peptide against trauma. Neuroreport. 1998 Dec 21; 9(18):4131-6.
Panizzon KL, Shin D, Frautschy S, Wallis RA. PMID: 9926861.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures. J Neurosci. 1998 Dec 15; 18(24):10366-74.
Harris-White ME, Chu T, Balverde Z, Sigel JJ, Flanders KC, Frautschy SA. PMID: 9852574; PMCID: PMC6793343.
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PubMed Mentions:
17 Fields:
Translation:
Animals
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Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. J Neurosci. 1998 Oct 15; 18(20):8311-21.
Frautschy SA, Horn DL, Sigel JJ, Harris-White ME, Mendoza JJ, Yang F, Saido TC, Cole GM. PMID: 9763475; PMCID: PMC6792856.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Effect of chloroquine and leupeptin on intracellular accumulation of amyloid-beta (A beta) 1-42 peptide in a murine N9 microglial cell line. FEBS Lett. 1998 Oct 09; 436(3):439-44.
Chu T, Tran T, Yang F, Beech W, Cole GM, Frautschy SA. PMID: 9801165.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Spiral intercellular calcium waves in hippocampal slice cultures. J Neurophysiol. 1998 Feb; 79(2):1045-52.
Harris-White ME, Zanotti SA, Frautschy SA, Charles AC. PMID: 9463460.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am J Pathol. 1998 Feb; 152(2):379-89.
Yang F, Sun X, Beech W, Teter B, Wu S, Sigel J, Vinters HV, Frautschy SA, Cole GM. PMID: 9466564; PMCID: PMC1857963.
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PubMed Mentions:
59 Fields:
Translation:
HumansCells
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Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol. 1998 Jan; 152(1):307-17.
Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM. PMID: 9422548; PMCID: PMC1858113.
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PubMed Mentions:
225 Fields:
Translation:
HumansAnimalsCells
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Rodent models of Alzheimer's disease: rat A beta infusion approaches to amyloid deposits. Neurobiol Aging. 1996 Mar-Apr; 17(2):311-21.
Frautschy SA, Yang F, Calderón L, Cole GM. PMID: 8744413.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimals
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A fibroblast growth factor binding protein in human cerebral spinal fluid. Neuroreport. 1995 Apr 19; 6(6):886-8.
Hanneken A, Frautschy S, Galasko D, Baird A. PMID: 7612876.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Estrogen augments hypothalamicβ-endorphin secretion and activates an inhibitoryβ-endorphin short-loop feedback system. Endocrine. 1995 Apr; 3(4):273-5.
Frautschy SA, Sarkar DK. PMID: 21153174.
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PubMed Mentions: Fields:
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Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum. Brain Res. 1994 Dec 19; 667(1):138-42.
Mak K, Yang F, Vinters HV, Frautschy SA, Cole GM. PMID: 7895077.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimals
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Monoclonal antibody to the C-terminus of beta-amyloid. Neuroreport. 1994 Oct 27; 5(16):2117-20.
Yang F, Mak K, Vinters HV, Frautschy SA, Cole GM. PMID: 7865758.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Lack of long-term effects after beta-amyloid protein injections in rat brain. Neurobiol Aging. 1994 Sep-Oct; 15(5):601-7.
Winkler J, Connor DJ, Frautschy SA, Behl C, Waite JJ, Cole GM, Thal LJ. PMID: 7824051.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat. Eur J Neurosci. 1994 Mar 01; 6(3):355-63.
Logan A, Berry M, Gonzalez AM, Frautschy SA, Sporn MB, Baird A. PMID: 8019673.
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PubMed Mentions:
65 Fields:
Translation:
Animals
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A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury. J Neurosci. 1992 Oct; 12(10):3828-37.
Logan A, Frautschy SA, Gonzalez AM, Baird A. PMID: 1403086; PMCID: PMC4086626.
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PubMed Mentions:
65 Fields:
Translation:
Animals
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Solvent effects on beta protein toxicity in vivo. Neurobiol Aging. 1992 Sep-Oct; 13(5):595-9.
Waite J, Cole GM, Frautschy SA, Connor DJ, Thal LJ. PMID: 1461348.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Enhanced expression of transforming growth factor beta 1 in the rat brain after a localized cerebral injury. Brain Res. 1992 Aug 07; 587(2):216-25.
Logan A, Frautschy SA, Gonzalez AM, Sporn MB, Baird A. PMID: 1525658; PMCID: PMC4310563.
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PubMed Mentions:
47 Fields:
Translation:
Animals
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Pituitary portal plasma levels of oxytocin during the estrous cycle, lactation, and hyperprolactinemia. Ann N Y Acad Sci. 1992 Jun 12; 652:397-410.
Sarkar DK, Frautschy SA, Mitsugi N. PMID: 1626839; PMCID: PMC4251598.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid. Am J Pathol. 1992 Jun; 140(6):1389-99.
Frautschy SA, Cole GM, Baird A. PMID: 1376558; PMCID: PMC1886549.
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PubMed Mentions:
48 Fields:
Translation:
Animals
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Effects of injected Alzheimer beta-amyloid cores in rat brain. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8362-6.
Frautschy SA, Baird A, Cole GM. PMID: 1924295; PMCID: PMC52508.
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PubMed Mentions:
64 Fields:
Translation:
HumansAnimals
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Localization of basic fibroblast growth factor and its mRNA after CNS injury. Brain Res. 1991 Jul 12; 553(2):291-9.
Frautschy SA, Walicke PA, Baird A. PMID: 1933286; PMCID: PMC4352091.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Expression of basic fibroblast growth factor and its receptor in the rat subfornical organ. Neuroendocrinology. 1991 Jul; 54(1):55-61.
Frautschy SA, Gonzalez AM, Martinez Murillo R, Carceller F, Cuevas P, Baird A. PMID: 1656299; PMCID: PMC4237606.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Basic fibroblast growth factor and central nervous system injury. Ann N Y Acad Sci. 1991; 638:474-6.
Logan A, Frautschy SA, Baird A. PMID: 1785823; PMCID: PMC4086467.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Facilitatory role of neuropeptide Y on the onset of puberty: effect of immunoneutralization of neuropeptide Y on the release of luteinizing hormone and luteinizing-hormone-releasing hormone. Neuroendocrinology. 1990 Jul; 52(1):112-5.
Minami S, Frautschy SA, Plotsky PM, Sutton SW, Sarkar DK. PMID: 2118604; PMCID: PMC4086632.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Effect of dexamethasone on gonadotrophin secretion in the gonadectomized sow and boar. Can J Vet Res. 1989 Oct; 53(4):490-2.
Frautschy SA, Gaon D, Liptrap RM. PMID: 2512005; PMCID: PMC1255582.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Chronic inhibition of hypothalamic-pituitary-ovarian axis and body weight gain by brain-directed delivery of estradiol-17 beta in female rats. Neuroendocrinology. 1989 Aug; 50(2):204-10.
Sarkar DK, Friedman SJ, Yen SS, Frautschy SA. PMID: 2674763; PMCID: PMC4352090.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Anovulation and plasma hormone concentrations after administration of dexamethasone during the middle of the luteal phase in sows undergoing estrous cycles. Am J Vet Res. 1988 Aug; 49(8):1270-5.
Frautschy SA, Liptrap RM. PMID: 3140694.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Antibiotics in microbial ecology : Isolation and structure assignment of several new antibacterial compounds from the insect-symbiotic bacteriaXenorhabdus spp. J Chem Ecol. 1981 May; 7(3):589-97.
Paul VJ, Frautschy S, Fenical W, Nealson KH. PMID: 24420598.
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PubMed Mentions:
35 Fields: