Ajit S Divakaruni

Title(s)Assistant Professor, Molecular and Medical Pharmacology
SchoolMedicine
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    1. Measuring CPT-1-mediated respiration in permeabilized cells and isolated mitochondria. STAR Protoc. 2021 Sep 17; 2(3):100687. Yang K, Doan MT, Stiles L, Divakaruni AS. PMID: 34401773.
      View in: PubMed   Mentions:
    2. A Single LC-MS/MS Analysis to Quantify CoA Biosynthetic Intermediates and Short-Chain Acyl CoAs. Metabolites. 2021 Jul 21; 11(8). Jones AE, Arias NJ, Acevedo A, Reddy ST, Divakaruni AS, Meriwether D. PMID: 34436409.
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    3. Adipocytes Provide Fatty Acids to Acute Lymphoblastic Leukemia Cells. Front Oncol. 2021; 11:665763. Tucci J, Chen T, Margulis K, Orgel E, Paszkiewicz RL, Cohen MD, Oberley MJ, Wahhab R, Jones AE, Divakaruni AS, Hsu CC, Noll SE, Sheng X, Zare RN, Mittelman SD. PMID: 33968771.
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    4. Deuterium-Stabilized (R)-Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPAR? Activity. Hepatol Commun. 2021 Aug; 5(8):1412-1425. Jacques V, Bolze S, Hallakou-Bozec S, Czarnik AW, Divakaruni AS, Fouqueray P, Murphy AN, Van der Ploeg LHT, DeWitt S. PMID: 34430785.
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    5. Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling. EMBO Rep. 2020 12 03; 21(12):e49634. Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein AJ, Desousa BR, Acín-Pérez R, Petcherski A, Assali EA, Stiles L, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, Shirihai OS. PMID: 33275313.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    6. Forces, fluxes, and fuels: tracking mitochondrial metabolism by integrating measurements of membrane potential, respiration, and metabolites. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C80-C91. Jones AE, Sheng L, Acevedo A, Veliova M, Shirihai OS, Stiles L, Divakaruni AS. PMID: 33147057.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner. Cell Mol Gastroenterol Hepatol. 2021; 11(2):389-406. Chella Krishnan K, Floyd RR, Sabir S, Jayasekera DW, Leon-Mimila PV, Jones AE, Cortez AA, Shravah V, Péterfy M, Stiles L, Canizales-Quinteros S, Divakaruni AS, Huertas-Vazquez A, Lusis AJ. PMID: 32942044.
      View in: PubMed   Mentions: 5     Fields:    
    8. Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy. iScience. 2020 Aug 13; 23(9):101453. Sperry J, Condro MC, Guo L, Braas D, Vanderveer-Harris N, Kim KKO, Pope WB, Divakaruni AS, Lai A, Christofk H, Castro MG, Lowenstein PR, Le Belle JE, Kornblum HI. PMID: 32861192.
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    9. Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome. Cell Metab. 2020 07 07; 32(1):128-143.e5. Hsieh WY, Zhou QD, York AG, Williams KJ, Scumpia PO, Kronenberger EB, Hoi XP, Su B, Chi X, Bui VL, Khialeeva E, Kaplan A, Son YM, Divakaruni AS, Sun J, Smale ST, Flavell RA, Bensinger SJ. PMID: 32516576.
      View in: PubMed   Mentions: 10     Fields:    
    10. A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO J. 2020 07 01; 39(13):e104073. Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. PMID: 32432379.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    11. Macrophage activation as an archetype of mitochondrial repurposing. Mol Aspects Med. 2020 02; 71:100838. Jones AE, Divakaruni AS. PMID: 31954522.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP. J Biol Chem. 2020 01 31; 295(5):1369-1384. Cao DY, Spivia WR, Veiras LC, Khan Z, Peng Z, Jones AE, Bernstein EA, Saito S, Okwan-Duodu D, Parker SJ, Giani JF, Divakaruni AS, Van Eyk JE, Bernstein KE. PMID: 31871049.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    13. Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury. Mol Metab. 2020 02; 32:122-135. Cordes T, Lucas A, Divakaruni AS, Murphy AN, Cabrales P, Metallo CM. PMID: 32029222.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. Do Two Mitochondrial Wrongs Help Make Cells Right? Trends Mol Med. 2020 01; 26(1):3-6. Divakaruni AS, Murphy AN. PMID: 31813762.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    15. Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice. JCI Insight. 2019 04 16; 5. Woodall BP, Orogo AM, Najor RH, Cortez MQ, Moreno ER, Wang H, Divakaruni AS, Murphy AN, Gustafsson ÅB. PMID: 30990467.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    16. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic ß Cell Function. Cell Rep. 2018 12 04; 25(10):2904-2918.e8. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. PMID: 30517875.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span. APL Bioeng. 2018 Sep; 2(3). Sessions AO, Min P, Cordes T, Weickert BJ, Divakaruni AS, Murphy AN, Metallo CM, Engler AJ. PMID: 30105314.
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    18. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab. 2018 09 04; 28(3):490-503.e7. Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN. PMID: 30043752.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    19. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab. 2018 09 04; 28(3):504-515.e7. Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L. PMID: 30043753.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    20. In situ measurements of mitochondrial matrix enzyme activities using plasma and mitochondrial membrane permeabilization agents. Anal Biochem. 2018 07 01; 552:60-65. Divakaruni AS, Andreyev AY, Rogers GW, Murphy AN. PMID: 28987935.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Impaired mitophagy facilitates mitochondrial damage in Danon disease. J Mol Cell Cardiol. 2017 07; 108:86-94. Hashem SI, Murphy AN, Divakaruni AS, Klos ML, Nelson BC, Gault EC, Rowland TJ, Perry CN, Gu Y, Dalton ND, Bradford WH, Devaney EJ, Peterson KL, Jones KL, Taylor MRG, Chen J, Chi NC, Adler ED. PMID: 28526246.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    22. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 04 03; 216(4):1091-1105. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN. PMID: 28254829.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    23. LKB1 promotes metabolic flexibility in response to energy stress. . 2017 09; 43(Pt B):208-217. Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM. PMID: 28034771.
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    24. Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Rep. 2016 08 09; 16(6):1536-1547. Zhang H, Badur MG, Divakaruni AS, Parker SJ, Jäger C, Hiller K, Murphy AN, Metallo CM. PMID: 27477285.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    25. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 07; 68(7):1614-26. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. PMID: 26815411.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    26. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016 Jul 01; 291(27):14274-14284. Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo CM. PMID: 27189937.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    27. Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death. Sci Rep. 2016 Mar 02; 6:22538. Ding B, Parmigiani A, Divakaruni AS, Archer K, Murphy AN, Budanov AV. PMID: 26932729.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    28. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69. Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. PMID: 26611103.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    29. Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis. Nat Chem Biol. 2016 Jan; 12(1):15-21. Green CR, Wallace M, Divakaruni AS, Phillips SA, Murphy AN, Ciaraldi TP, Metallo CM. PMID: 26571352.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    30. GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop. Diabetes. 2015 Sep; 64(9):3273-84. Giacco F, Du X, Carratú A, Gerfen GJ, D'Apolito M, Giardino I, Rasola A, Marin O, Divakaruni AS, Murphy AN, Shah MS, Brownlee M. PMID: 26294429.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    31. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. PMID: 26203188.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    32. Mitochondrial reprogramming induced by CaMKIId mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39. Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. PMID: 25605649.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    33. Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol Cell. 2014 Nov 06; 56(3):425-435. Vacanti NM, Divakaruni AS, Green CR, Parker SJ, Henry RR, Ciaraldi TP, Murphy AN, Metallo CM. PMID: 25458843.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    34. Measuring Mitochondrial Function in Permeabilized Cells Using the Seahorse XF Analyzer or a Clark-Type Oxygen Electrode. Curr Protoc Toxicol. 2014 May 27; 60:25.2.1-16. Divakaruni AS, Rogers GW, Murphy AN. PMID: 24865646.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    35. Assessment of fatty acid beta oxidation in cells and isolated mitochondria. Curr Protoc Toxicol. 2014 May 27; 60:25.3.1-19. Rogers GW, Nadanaciva S, Swiss R, Divakaruni AS, Will Y. PMID: 24865647.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    36. Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function. Int J Cardiol. 2014 Aug 01; 175(2):297-306. Yamazaki KG, Andreyev AY, Ortiz-Vilchis P, Petrosyan S, Divakaruni AS, Wiley SE, De La Fuente C, Perkins G, Ceballos G, Villarreal F, Murphy AN. PMID: 24908200.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    37. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Res. 2014 Jun 15; 74(12):3317-31. Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, Growney JD, Vander Heiden MG, Murphy AN, Pagliarini R, Metallo CM. PMID: 24755473.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    38. Analysis and interpretation of microplate-based oxygen consumption and pH data. Methods Enzymol. 2014; 547:309-54. Divakaruni AS, Paradyse A, Ferrick DA, Murphy AN, Jastroch M. PMID: 25416364.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    39. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab. 2014 Apr; 3(2):114-23. Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. PMID: 24634817.
      View in: PubMed   Mentions: 69     Fields:    
    40. Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med. 2013 Jun; 5(6):904-18. Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN. PMID: 23703906.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    41. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One. 2013; 8(5):e61551. Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM, Gracheva E, Korshunova Y, Trusgnich M, Karr R, Wiley SE, Divakaruni AS, Murphy AN, Vigueira PA, Finck BN, Kletzien RF. PMID: 23690925.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    42. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5422-7. Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA, Henry RR, McDonald WG, Colca JR, Simon MI, Ciaraldi TP, Murphy AN. PMID: 23513224.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    43. Fatty acids change the conformation of uncoupling protein 1 (UCP1). J Biol Chem. 2012 Oct 26; 287(44):36845-53. Divakaruni AS, Humphrey DM, Brand MD. PMID: 22952235.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    44. Cell biology. A mitochondrial mystery, solved. Science. 2012 Jul 06; 337(6090):41-3. Divakaruni AS, Murphy AN. PMID: 22767917.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    45. The regulation and physiology of mitochondrial proton leak. Physiology (Bethesda). 2011 Jun; 26(3):192-205. Divakaruni AS, Brand MD. PMID: 21670165.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    46. Mitochondrial uncoupling and lifespan. Mech Ageing Dev. 2010 Jul-Aug; 131(7-8):463-72. Mookerjee SA, Divakaruni AS, Jastroch M, Brand MD. PMID: 20363244.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    47. The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta. 2010 Jun-Jul; 1797(6-7):785-91. Azzu V, Jastroch M, Divakaruni AS, Brand MD. PMID: 20211596.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    48. Mitochondrial proton and electron leaks. Essays Biochem. 2010; 47:53-67. Jastroch M, Divakaruni AS, Mookerjee S, Treberg JR, Brand MD. PMID: 20533900.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimalsCells
    49. Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity. J Neurochem. 2009 Aug; 110(3):990-1004. Gerencser AA, Mark KA, Hubbard AE, Divakaruni AS, Mehrabian Z, Nicholls DG, Polster BM. PMID: 19493161.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells