Loading...

Divakaruni, Ajit S

Title(s)Assistant Professor, Molecular And Medical Pharmacology
Phone310-794-9194
vCardDownload vCard

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Jones AE, Divakaruni AS. Macrophage activation as an archetype of mitochondrial repurposing. Mol Aspects Med. 2020 Feb; 71:100838. PMID: 31954522.
      View in: PubMed
    2. Cao DY, Spivia WR, Veiras LC, Khan Z, Peng Z, Jones AE, Bernstein EA, Saito S, Okwan-Duodu D, Parker SJ, Giani JF, Divakaruni AS, Van Eyk JE, Bernstein KE. ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP. J Biol Chem. 2020 Jan 31; 295(5):1369-1384. PMID: 31871049.
      View in: PubMed
    3. Cordes T, Lucas A, Divakaruni AS, Murphy AN, Cabrales P, Metallo CM. Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury. Mol Metab. 2020 Feb; 32:122-135. PMID: 32029222.
      View in: PubMed
    4. Divakaruni AS, Murphy AN. Do Two Mitochondrial Wrongs Help Make Cells Right? Trends Mol Med. 2020 Jan; 26(1):3-6. PMID: 31813762.
      View in: PubMed
    5. Woodall BP, Orogo AM, Najor RH, Cortez MQ, Moreno ER, Wang H, Divakaruni AS, Murphy AN, Gustafsson ÅB. Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice. JCI Insight. 2019 Apr 16; 5. PMID: 30990467.
      View in: PubMed
    6. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic ß Cell Function. Cell Rep. 2018 12 04; 25(10):2904-2918.e8. PMID: 30517875.
      View in: PubMed
    7. Sessions AO, Min P, Cordes T, Weickert BJ, Divakaruni AS, Murphy AN, Metallo CM, Engler AJ. Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span. APL Bioeng. 2018 Sep; 2(3). PMID: 30105314.
      View in: PubMed
    8. Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab. 2018 09 04; 28(3):490-503.e7. PMID: 30043752.
      View in: PubMed
    9. Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab. 2018 09 04; 28(3):504-515.e7. PMID: 30043753.
      View in: PubMed
    10. Divakaruni AS, Andreyev AY, Rogers GW, Murphy AN. In situ measurements of mitochondrial matrix enzyme activities using plasma and mitochondrial membrane permeabilization agents. Anal Biochem. 2018 07 01; 552:60-65. PMID: 28987935.
      View in: PubMed
    11. Hashem SI, Murphy AN, Divakaruni AS, Klos ML, Nelson BC, Gault EC, Rowland TJ, Perry CN, Gu Y, Dalton ND, Bradford WH, Devaney EJ, Peterson KL, Jones KL, Taylor MRG, Chen J, Chi NC, Adler ED. Impaired mitophagy facilitates mitochondrial damage in Danon disease. J Mol Cell Cardiol. 2017 07; 108:86-94. PMID: 28526246.
      View in: PubMed
    12. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 04 03; 216(4):1091-1105. PMID: 28254829.
      View in: PubMed
    13. Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM. LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng. 2017 09; 43(Pt B):208-217. PMID: 28034771.
      View in: PubMed
    14. Zhang H, Badur MG, Divakaruni AS, Parker SJ, Jäger C, Hiller K, Murphy AN, Metallo CM. Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Rep. 2016 08 09; 16(6):1536-1547. PMID: 27477285.
      View in: PubMed
    15. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 07; 68(7):1614-26. PMID: 26815411.
      View in: PubMed
    16. Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo CM. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016 Jul 01; 291(27):14274-84. PMID: 27189937.
      View in: PubMed
    17. Ding B, Parmigiani A, Divakaruni AS, Archer K, Murphy AN, Budanov AV. Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death. Sci Rep. 2016 Mar 02; 6:22538. PMID: 26932729.
      View in: PubMed
    18. Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69. PMID: 26611103.
      View in: PubMed
    19. Green CR, Wallace M, Divakaruni AS, Phillips SA, Murphy AN, Ciaraldi TP, Metallo CM. Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis. Nat Chem Biol. 2016 Jan; 12(1):15-21. PMID: 26571352.
      View in: PubMed
    20. Giacco F, Du X, Carratú A, Gerfen GJ, D'Apolito M, Giardino I, Rasola A, Marin O, Divakaruni AS, Murphy AN, Shah MS, Brownlee M. GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop. Diabetes. 2015 Sep; 64(9):3273-84. PMID: 26294429.
      View in: PubMed
    21. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. PMID: 26203188.
      View in: PubMed
    22. Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. Mitochondrial reprogramming induced by CaMKIId mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39. PMID: 25605649.
      View in: PubMed
    23. Vacanti NM, Divakaruni AS, Green CR, Parker SJ, Henry RR, Ciaraldi TP, Murphy AN, Metallo CM. Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol Cell. 2014 Nov 06; 56(3):425-35. PMID: 25458843.
      View in: PubMed
    24. Divakaruni AS, Rogers GW, Murphy AN. Measuring Mitochondrial Function in Permeabilized Cells Using the Seahorse XF Analyzer or a Clark-Type Oxygen Electrode. Curr Protoc Toxicol. 2014 May 27; 60:25.2.1-16. PMID: 24865646.
      View in: PubMed
    25. Rogers GW, Nadanaciva S, Swiss R, Divakaruni AS, Will Y. Assessment of fatty acid beta oxidation in cells and isolated mitochondria. Curr Protoc Toxicol. 2014 May 27; 60:25.3.1-19. PMID: 24865647.
      View in: PubMed
    26. Yamazaki KG, Andreyev AY, Ortiz-Vilchis P, Petrosyan S, Divakaruni AS, Wiley SE, De La Fuente C, Perkins G, Ceballos G, Villarreal F, Murphy AN. Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function. Int J Cardiol. 2014 Aug 01; 175(2):297-306. PMID: 24908200.
      View in: PubMed
    27. Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, Growney JD, Vander Heiden MG, Murphy AN, Pagliarini R, Metallo CM. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Res. 2014 Jun 15; 74(12):3317-31. PMID: 24755473.
      View in: PubMed
    28. Divakaruni AS, Paradyse A, Ferrick DA, Murphy AN, Jastroch M. Analysis and interpretation of microplate-based oxygen consumption and pH data. Methods Enzymol. 2014; 547:309-54. PMID: 25416364.
      View in: PubMed
    29. Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab. 2014 Apr; 3(2):114-23. PMID: 24634817.
      View in: PubMed
    30. Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN. Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med. 2013 Jun; 5(6):904-18. PMID: 23703906.
      View in: PubMed
    31. Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM, Gracheva E, Korshunova Y, Trusgnich M, Karr R, Wiley SE, Divakaruni AS, Murphy AN, Vigueira PA, Finck BN, Kletzien RF. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One. 2013; 8(5):e61551. PMID: 23690925.
      View in: PubMed
    32. Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA, Henry RR, McDonald WG, Colca JR, Simon MI, Ciaraldi TP, Murphy AN. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5422-7. PMID: 23513224.
      View in: PubMed
    33. Divakaruni AS, Humphrey DM, Brand MD. Fatty acids change the conformation of uncoupling protein 1 (UCP1). J Biol Chem. 2012 Oct 26; 287(44):36845-53. PMID: 22952235.
      View in: PubMed
    34. Divakaruni AS, Murphy AN. Cell biology. A mitochondrial mystery, solved. Science. 2012 Jul 06; 337(6090):41-3. PMID: 22767917.
      View in: PubMed
    35. Divakaruni AS, Brand MD. The regulation and physiology of mitochondrial proton leak. Physiology (Bethesda). 2011 Jun; 26(3):192-205. PMID: 21670165.
      View in: PubMed
    36. Mookerjee SA, Divakaruni AS, Jastroch M, Brand MD. Mitochondrial uncoupling and lifespan. Mech Ageing Dev. 2010 Jul-Aug; 131(7-8):463-72. PMID: 20363244.
      View in: PubMed
    37. Azzu V, Jastroch M, Divakaruni AS, Brand MD. The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta. 2010 Jun-Jul; 1797(6-7):785-91. PMID: 20211596.
      View in: PubMed
    38. Jastroch M, Divakaruni AS, Mookerjee S, Treberg JR, Brand MD. Mitochondrial proton and electron leaks. Essays Biochem. 2010; 47:53-67. PMID: 20533900.
      View in: PubMed
    39. Gerencser AA, Mark KA, Hubbard AE, Divakaruni AS, Mehrabian Z, Nicholls DG, Polster BM. Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity. J Neurochem. 2009 Aug; 110(3):990-1004. PMID: 19493161.
      View in: PubMed