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Ajit S Divakaruni

Title(s)Assistant Professor, Molecular and Medical Pharmacology
SchoolMedicine
Address760 Westwood Plaza 23-120
Los Angeles CA 90024
Phone310-794-9194
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    1. Liver Pyruvate Kinase Promotes NAFLD/NASH in both Mice and Humans in a Sex-Specific Manner. Cell Mol Gastroenterol Hepatol. 2020 Sep 14. Chella Krishnan K, Floyd RR, Sabir S, Jayasekera DW, Leon-Mimila PV, Jones AE, Cortez AA, Shravah V, Péterfy M, Stiles L, Canizales-Quinteros S, Divakaruni AS, Huertas-Vazquez A, Lusis AJ. PMID: 32942044.
      View in: PubMed   Mentions:    Fields:    
    2. Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy. iScience. 2020 Aug 13; 23(9):101453. Sperry J, Condro MC, Guo L, Braas D, Vanderveer-Harris N, Kim KKO, Pope WB, Divakaruni AS, Lai A, Christofk H, Castro MG, Lowenstein PR, Le Belle JE, Kornblum HI. PMID: 32861192.
      View in: PubMed   Mentions:
    3. Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome. Cell Metab. 2020 Jul 07; 32(1):128-143.e5. Hsieh WY, Zhou QD, York AG, Williams KJ, Scumpia PO, Kronenberger EB, Hoi XP, Su B, Chi X, Bui VL, Khialeeva E, Kaplan A, Son YM, Divakaruni AS, Sun J, Smale ST, Flavell RA, Bensinger SJ. PMID: 32516576.
      View in: PubMed   Mentions:    Fields:    
    4. A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO J. 2020 Jul 01; 39(13):e104073. Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. PMID: 32432379.
      View in: PubMed   Mentions: 2     Fields:    
    5. Macrophage activation as an archetype of mitochondrial repurposing. Mol Aspects Med. 2020 02; 71:100838. Jones AE, Divakaruni AS. PMID: 31954522.
      View in: PubMed   Mentions:    Fields:    
    6. ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP. J Biol Chem. 2020 01 31; 295(5):1369-1384. Cao DY, Spivia WR, Veiras LC, Khan Z, Peng Z, Jones AE, Bernstein EA, Saito S, Okwan-Duodu D, Parker SJ, Giani JF, Divakaruni AS, Van Eyk JE, Bernstein KE. PMID: 31871049.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury. Mol Metab. 2020 02; 32:122-135. Cordes T, Lucas A, Divakaruni AS, Murphy AN, Cabrales P, Metallo CM. PMID: 32029222.
      View in: PubMed   Mentions: 2     Fields:    
    8. Do Two Mitochondrial Wrongs Help Make Cells Right? Trends Mol Med. 2020 Jan; 26(1):3-6. Divakaruni AS, Murphy AN. PMID: 31813762.
      View in: PubMed   Mentions:    Fields:    
    9. Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice. JCI Insight. 2019 04 16; 5. Woodall BP, Orogo AM, Najor RH, Cortez MQ, Moreno ER, Wang H, Divakaruni AS, Murphy AN, Gustafsson ÅB. PMID: 30990467.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic ß Cell Function. Cell Rep. 2018 12 04; 25(10):2904-2918.e8. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. PMID: 30517875.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span. APL Bioeng. 2018 Sep; 2(3). Sessions AO, Min P, Cordes T, Weickert BJ, Divakaruni AS, Murphy AN, Metallo CM, Engler AJ. PMID: 30105314.
      View in: PubMed   Mentions:
    12. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab. 2018 09 04; 28(3):490-503.e7. Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN. PMID: 30043752.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    13. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab. 2018 09 04; 28(3):504-515.e7. Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L. PMID: 30043753.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    14. In situ measurements of mitochondrial matrix enzyme activities using plasma and mitochondrial membrane permeabilization agents. Anal Biochem. 2018 07 01; 552:60-65. Divakaruni AS, Andreyev AY, Rogers GW, Murphy AN. PMID: 28987935.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Impaired mitophagy facilitates mitochondrial damage in Danon disease. J Mol Cell Cardiol. 2017 07; 108:86-94. Hashem SI, Murphy AN, Divakaruni AS, Klos ML, Nelson BC, Gault EC, Rowland TJ, Perry CN, Gu Y, Dalton ND, Bradford WH, Devaney EJ, Peterson KL, Jones KL, Taylor MRG, Chen J, Chi NC, Adler ED. PMID: 28526246.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    16. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 04 03; 216(4):1091-1105. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN. PMID: 28254829.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    17. LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng. 2017 09; 43(Pt B):208-217. Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM. PMID: 28034771.
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    18. Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Rep. 2016 08 09; 16(6):1536-1547. Zhang H, Badur MG, Divakaruni AS, Parker SJ, Jäger C, Hiller K, Murphy AN, Metallo CM. PMID: 27477285.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    19. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 07; 68(7):1614-26. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. PMID: 26815411.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    20. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016 Jul 01; 291(27):14274-84. Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo CM. PMID: 27189937.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    21. Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death. Sci Rep. 2016 Mar 02; 6:22538. Ding B, Parmigiani A, Divakaruni AS, Archer K, Murphy AN, Budanov AV. PMID: 26932729.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    22. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69. Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. PMID: 26611103.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    23. Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis. Nat Chem Biol. 2016 Jan; 12(1):15-21. Green CR, Wallace M, Divakaruni AS, Phillips SA, Murphy AN, Ciaraldi TP, Metallo CM. PMID: 26571352.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    24. GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop. Diabetes. 2015 Sep; 64(9):3273-84. Giacco F, Du X, Carratú A, Gerfen GJ, D'Apolito M, Giardino I, Rasola A, Marin O, Divakaruni AS, Murphy AN, Shah MS, Brownlee M. PMID: 26294429.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    25. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. PMID: 26203188.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Mitochondrial reprogramming induced by CaMKIId mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39. Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. PMID: 25605649.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    27. Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol Cell. 2014 Nov 06; 56(3):425-35. Vacanti NM, Divakaruni AS, Green CR, Parker SJ, Henry RR, Ciaraldi TP, Murphy AN, Metallo CM. PMID: 25458843.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    28. Measuring Mitochondrial Function in Permeabilized Cells Using the Seahorse XF Analyzer or a Clark-Type Oxygen Electrode. Curr Protoc Toxicol. 2014 May 27; 60:25.2.1-16. Divakaruni AS, Rogers GW, Murphy AN. PMID: 24865646.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    29. Assessment of fatty acid beta oxidation in cells and isolated mitochondria. Curr Protoc Toxicol. 2014 May 27; 60:25.3.1-19. Rogers GW, Nadanaciva S, Swiss R, Divakaruni AS, Will Y. PMID: 24865647.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    30. Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function. Int J Cardiol. 2014 Aug 01; 175(2):297-306. Yamazaki KG, Andreyev AY, Ortiz-Vilchis P, Petrosyan S, Divakaruni AS, Wiley SE, De La Fuente C, Perkins G, Ceballos G, Villarreal F, Murphy AN. PMID: 24908200.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    31. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Res. 2014 Jun 15; 74(12):3317-31. Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, Growney JD, Vander Heiden MG, Murphy AN, Pagliarini R, Metallo CM. PMID: 24755473.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    32. Analysis and interpretation of microplate-based oxygen consumption and pH data. Methods Enzymol. 2014; 547:309-54. Divakaruni AS, Paradyse A, Ferrick DA, Murphy AN, Jastroch M. PMID: 25416364.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    33. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab. 2014 Apr; 3(2):114-23. Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. PMID: 24634817.
      View in: PubMed   Mentions: 53     Fields:    
    34. Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med. 2013 Jun; 5(6):904-18. Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN. PMID: 23703906.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    35. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One. 2013; 8(5):e61551. Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM, Gracheva E, Korshunova Y, Trusgnich M, Karr R, Wiley SE, Divakaruni AS, Murphy AN, Vigueira PA, Finck BN, Kletzien RF. PMID: 23690925.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    36. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5422-7. Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA, Henry RR, McDonald WG, Colca JR, Simon MI, Ciaraldi TP, Murphy AN. PMID: 23513224.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    37. Fatty acids change the conformation of uncoupling protein 1 (UCP1). J Biol Chem. 2012 Oct 26; 287(44):36845-53. Divakaruni AS, Humphrey DM, Brand MD. PMID: 22952235.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    38. Cell biology. A mitochondrial mystery, solved. Science. 2012 Jul 06; 337(6090):41-3. Divakaruni AS, Murphy AN. PMID: 22767917.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. The regulation and physiology of mitochondrial proton leak. Physiology (Bethesda). 2011 Jun; 26(3):192-205. Divakaruni AS, Brand MD. PMID: 21670165.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    40. Mitochondrial uncoupling and lifespan. Mech Ageing Dev. 2010 Jul-Aug; 131(7-8):463-72. Mookerjee SA, Divakaruni AS, Jastroch M, Brand MD. PMID: 20363244.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    41. The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta. 2010 Jun-Jul; 1797(6-7):785-91. Azzu V, Jastroch M, Divakaruni AS, Brand MD. PMID: 20211596.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    42. Mitochondrial proton and electron leaks. Essays Biochem. 2010; 47:53-67. Jastroch M, Divakaruni AS, Mookerjee S, Treberg JR, Brand MD. PMID: 20533900.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    43. Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity. J Neurochem. 2009 Aug; 110(3):990-1004. Gerencser AA, Mark KA, Hubbard AE, Divakaruni AS, Mehrabian Z, Nicholls DG, Polster BM. PMID: 19493161.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
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