Ambre Marguerite Solange Bertholet
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| Title(s) | Assistant Professor, Physiology |
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| School | Medicine |
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| vCard | Download vCard |
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Research
Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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A cold-inducible phospholipid-protein interaction in brown fat mitochondria optimizes thermogenic capacity. bioRxiv. 2025 May 18.
Shimanaka Y, Tol MJ, Rocha-Roa C, Jellinek MJ, Cui L, Bender A, Bedard AH, Milner MG, Melillo B, Shoucri BM, Wong A, Williams KJ, Stiles L, Shum M, Weston TA, Cohn W, Whitelegge JP, Budin I, Bertholet AM, Cravatt BF, Young SG, Houten SM, Argmann C, Ford DA, Liesa M, Shirihai OS, Vanni S, Tontonoz P. PMID: 40463239; PMCID: PMC12132348.
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PubMed Mentions:
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The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. J Biol Chem. 2024 03; 300(3):105702.
Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. PMID: 38301896; PMCID: PMC10910128.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. bioRxiv. 2023 Aug 16.
Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. PMID: 37645724; PMCID: PMC10461965.
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Mitochondrial uncouplers impair human sperm motility without altering ATP content†. Biol Reprod. 2023 08 10; 109(2):192-203.
Skinner WM, Petersen NT, Unger B, Tang S, Tabarsi E, Lamm J, Jalalian L, Smith J, Bertholet AM, Xu K, Kirichok Y, Lishko PV. PMID: 37294625; PMCID: PMC10427809.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression. Antioxidants (Basel). 2022 Dec 22; 12(1).
Chang CF, Gunawan AL, Liparulo I, Zushin PH, Bertholet AM, Kirichok Y, Stahl A. PMID: 36670876; PMCID: PMC9854525.
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PubMed Mentions:
3
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Mitochondrial uncouplers induce proton leak by activating AAC and UCP1. Nature. 2022 06; 606(7912):180-187.
Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. PMID: 35614225; PMCID: PMC9646675.
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PubMed Mentions:
41 Fields:
Translation:
Cells
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Mitochondrial H+ Leak and Thermogenesis. Annu Rev Physiol. 2022 02 10; 84:381-407.
Bertholet AM, Kirichok Y. PMID: 34758268; PMCID: PMC8976115.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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The Use of the Patch-Clamp Technique to Study the Thermogenic Capacity of Mitochondria. J Vis Exp. 2021 05 03; (171).
Bertholet AM. PMID: 33999016.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold. J Biol Chem. 2021 Jan-Jun; 296:100632.
Allu PKR, Paulo E, Bertholet AM, Situ G, Lee SH, Wu Y, Gleason CE, Saha B, Chawla A, Wang B, Pearce D. PMID: 33865855; PMCID: PMC8121962.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Patch-Clamp Analysis of the Mitochondrial H+ Leak in Brown and Beige Fat. Front Physiol. 2020; 11:326.
Bertholet AM, Kirichok Y. PMID: 32351404; PMCID: PMC7174661.
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PubMed Mentions:
4
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H+ transport is an integral function of the mitochondrial ADP/ATP carrier. Nature. 2019 07; 571(7766):515-520.
Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y. PMID: 31341297; PMCID: PMC6662629.
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PubMed Mentions:
105 Fields:
Translation:
AnimalsCells
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The Mechanism FA-Dependent H+ Transport by UCP1. Handb Exp Pharmacol. 2019; 251:143-159.
Bertholet AM, Kirichok Y. PMID: 29797089.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2017 12 14; 171(7):1707.
Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. PMID: 29245014; PMCID: PMC5764896.
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PubMed Mentions:
5 Fields:
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Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 2017 Apr 04; 25(4):811-822.e4.
Bertholet AM, Kazak L, Chouchani ET, Bogaczynska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. PMID: 28380374; PMCID: PMC5448977.
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PubMed Mentions:
111 Fields:
Translation:
AnimalsCells
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UCP1: A transporter for H+ and fatty acid anions. Biochimie. 2017 Mar; 134:28-34.
Bertholet AM, Kirichok Y. PMID: 27984203; PMCID: PMC5461058.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Aug 11; 166(4):841-854.
Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. PMID: 27453471; PMCID: PMC4985267.
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PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
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Loss of functional OPA1 unbalances redox state: implications in dominant optic atrophy pathogenesis. Ann Clin Transl Neurol. 2016 Jun; 3(6):408-21.
Millet AM, Bertholet AM, Daloyau M, Reynier P, Galinier A, Devin A, Wissinguer B, Belenguer P, Davezac N. PMID: 27547769; PMCID: PMC4891995.
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PubMed Mentions:
21 Fields:
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OPA1 loss of function affects in vitro neuronal maturation. Brain. 2013 May; 136(Pt 5):1518-33.
Bertholet AM, Millet AM, Guillermin O, Daloyau M, Davezac N, Miquel MC, Belenguer P. PMID: 23543485.
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PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
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OPA1 (dys)functions. Semin Cell Dev Biol. 2010 Aug; 21(6):593-8.
Landes T, Leroy I, Bertholet A, Diot A, Khosrobakhsh F, Daloyau M, Davezac N, Miquel MC, Courilleau D, Guillou E, Olichon A, Lenaers G, Arnauné-Pelloquin L, Emorine LJ, Belenguer P. PMID: 20045077.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Involvement of hippocampal CA3 K(ATP) channels in contextual memory. Neuropharmacology. 2009 Mar; 56(3):615-25.
Betourne A, Bertholet AM, Labroue E, Halley H, Sun HS, Lorsignol A, Feng ZP, French RJ, Penicaud L, Lassalle JM, Frances B. PMID: 19059420.
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PubMed Mentions:
17 Fields:
Translation:
Animals
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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| Year | Publications |
|---|
| 2008 | 1 |
| 2010 | 1 |
| 2013 | 1 |
| 2016 | 3 |
| 2017 | 2 |
| 2019 | 2 |
| 2020 | 1 |
| 2021 | 3 |
| 2022 | 2 |
| 2023 | 2 |
| 2024 | 1 |
| 2025 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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