Ambre Marguerite Solange Bertholet

Title(s)Assistant Professor, Physiology
SchoolMedicine
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    Mechanisms of regulation of mitochondrial H+ leak and thermogenesis
    NIH R35GM143097Aug 1, 2021 - May 31, 2026
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. J Biol Chem. 2024 Mar; 300(3):105702. Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. PMID: 38301896; PMCID: PMC10910128.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. bioRxiv. 2023 Aug 16. Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. PMID: 37645724; PMCID: PMC10461965.
      View in: PubMed   Mentions:
    3. Mitochondrial uncouplers impair human sperm motility without altering ATP content†. Biol Reprod. 2023 08 10; 109(2):192-203. Skinner WM, Petersen NT, Unger B, Tang S, Tabarsi E, Lamm J, Jalalian L, Smith J, Bertholet AM, Xu K, Kirichok Y, Lishko PV. PMID: 37294625; PMCID: PMC10427809.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression. Antioxidants (Basel). 2022 Dec 22; 12(1). Chang CF, Gunawan AL, Liparulo I, Zushin PH, Bertholet AM, Kirichok Y, Stahl A. PMID: 36670876; PMCID: PMC9854525.
      View in: PubMed   Mentions: 2  
    5. Mitochondrial uncouplers induce proton leak by activating AAC and UCP1. Nature. 2022 06; 606(7912):180-187. Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. PMID: 35614225; PMCID: PMC9646675.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    6. Mitochondrial H+ Leak and Thermogenesis. Annu Rev Physiol. 2022 02 10; 84:381-407. Bertholet AM, Kirichok Y. PMID: 34758268; PMCID: PMC8976115.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    7. The Use of the Patch-Clamp Technique to Study the Thermogenic Capacity of Mitochondria. J Vis Exp. 2021 05 03; (171). Bertholet AM. PMID: 33999016.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    8. Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold. J Biol Chem. 2021 Jan-Jun; 296:100632. Allu PKR, Paulo E, Bertholet AM, Situ G, Lee SH, Wu Y, Gleason CE, Saha B, Chawla A, Wang B, Pearce D. PMID: 33865855; PMCID: PMC8121962.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. Patch-Clamp Analysis of the Mitochondrial H+ Leak in Brown and Beige Fat. Front Physiol. 2020; 11:326. Bertholet AM, Kirichok Y. PMID: 32351404; PMCID: PMC7174661.
      View in: PubMed   Mentions: 5  
    10. H+ transport is an integral function of the mitochondrial ADP/ATP carrier. Nature. 2019 07; 571(7766):515-520. Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y. PMID: 31341297; PMCID: PMC6662629.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    11. The Mechanism FA-Dependent H+ Transport by UCP1. Handb Exp Pharmacol. 2019; 251:143-159. Bertholet AM, Kirichok Y. PMID: 29797089.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    12. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2017 12 14; 171(7):1707. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. PMID: 29245014; PMCID: PMC5764896.
      View in: PubMed   Mentions: 5     Fields:    
    13. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 2017 Apr 04; 25(4):811-822.e4. Bertholet AM, Kazak L, Chouchani ET, Bogaczynska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. PMID: 28380374; PMCID: PMC5448977.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    14. UCP1: A transporter for H+ and fatty acid anions. Biochimie. 2017 Mar; 134:28-34. Bertholet AM, Kirichok Y. PMID: 27984203; PMCID: PMC5461058.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    15. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Aug 11; 166(4):841-854. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. PMID: 27453471; PMCID: PMC4985267.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    16. Loss of functional OPA1 unbalances redox state: implications in dominant optic atrophy pathogenesis. Ann Clin Transl Neurol. 2016 Jun; 3(6):408-21. Millet AM, Bertholet AM, Daloyau M, Reynier P, Galinier A, Devin A, Wissinguer B, Belenguer P, Davezac N. PMID: 27547769; PMCID: PMC4891995.
      View in: PubMed   Mentions: 20     Fields:    
    17. OPA1 loss of function affects in vitro neuronal maturation. Brain. 2013 May; 136(Pt 5):1518-33. Bertholet AM, Millet AM, Guillermin O, Daloyau M, Davezac N, Miquel MC, Belenguer P. PMID: 23543485.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    18. OPA1 (dys)functions. Semin Cell Dev Biol. 2010 Aug; 21(6):593-8. Landes T, Leroy I, Bertholet A, Diot A, Khosrobakhsh F, Daloyau M, Davezac N, Miquel MC, Courilleau D, Guillou E, Olichon A, Lenaers G, Arnauné-Pelloquin L, Emorine LJ, Belenguer P. PMID: 20045077.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    19. Involvement of hippocampal CA3 K(ATP) channels in contextual memory. Neuropharmacology. 2009 Mar; 56(3):615-25. Betourne A, Bertholet AM, Labroue E, Halley H, Sun HS, Lorsignol A, Feng ZP, French RJ, Penicaud L, Lassalle JM, Frances B. PMID: 19059420.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
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