Linsey Stiles

Title(s)Associate Adjunct Professor, Medicine
SchoolMedicine
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    Title(s)Associate Adjunct Professor, Molecular and Medical Pharmacology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Nature. 2023 Mar; 615(7953):712-719. Han M, Bushong EA, Segawa M, Tiard A, Wong A, Brady MR, Momcilovic M, Wolf DM, Zhang R, Petcherski A, Madany M, Xu S, Lee JT, Poyurovsky MV, Olszewski K, Holloway T, Gomez A, John MS, Dubinett SM, Koehler CM, Shirihai OS, Stiles L, Lisberg A, Soatto S, Sadeghi S, Ellisman MH, Shackelford DB. PMID: 36922590; PMCID: PMC10033418.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. A novel approach to measure complex V ATP hydrolysis in frozen cell lysates and tissue homogenates. Life Sci Alliance. 2023 Apr; 6(4). Fernandez-Del-Rio L, Beninc? C, Villalobos F, Shu C, Stiles L, Liesa M, Divakaruni AS, Acin-Perez R, Shirihai OS. PMID: 36918278; PMCID: PMC10019470.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA. EMBO J. 2023 Mar 14; e111901. Ngo J, Choi DW, Stanley IA, Stiles L, Molina AJA, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, Miller N, Baghdasarian S, Kim-Vasquez D, Jones AE, Roach B, Gutierrez V, Erion K, Divakaruni AS, Liesa M, Danial NN, Shirihai OS. PMID: 36917141.
      View in: PubMed   Mentions:    Fields:    
    4. Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies. EMBO J. 2023 Mar 13; e111699. Acin-Perez R, Beninc? C, Fernandez Del Rio L, Shu C, Baghdasarian S, Zanette V, Gerle C, Jiko C, Khairallah R, Khan S, Rincon Fernandez Pacheco D, Shabane B, Erion K, Masand R, Dugar S, Ghenoiu C, Schreiner G, Stiles L, Liesa M, Shirihai OS. PMID: 36912136.
      View in: PubMed   Mentions:    Fields:    
    5. Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas. Nat Commun. 2022 11 17; 13(1):7037. Do Rhee K, Wang Y, Ten Hoeve J, Stiles L, Nguyen TTT, Zhang X, Vergnes L, Reue K, Shirihai O, Bok D, Yang XJ. PMID: 36396639; PMCID: PMC9672129.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Vitamin B3, nicotinamide, enhances mitochondrial metabolism to promote differentiation of the retinal pigment epithelium. J Biol Chem. 2022 09; 298(9):102286. Hazim RA, Paniagua AE, Tang L, Yang K, Kim KKO, Stiles L, Divakaruni AS, Williams DS. PMID: 35868562; PMCID: PMC9396405.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. TNFα-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice. Brain Sci. 2022 Jul 09; 12(7). Desai M, Stiles L, Torsoni AS, Torsoni MA, Shirihai OS, Ross MG. PMID: 35884707; PMCID: PMC9316209.
      View in: PubMed   Mentions: 1  
    8. Characterizing the metabolic profile of dexamethasone treated human trabecular meshwork cells. Exp Eye Res. 2022 01; 214:108888. Graybeal K, Sanchez L, Zhang C, Stiles L, Zheng JJ. PMID: 34896106; PMCID: PMC9272781.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance. Mol Metab. 2022 01; 55:101403. Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M. PMID: 34823065; PMCID: PMC8689243.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice. Physiol Rep. 2021 11; 9(21):e15068. Moore TM, Terrazas A, Strumwasser AR, Lin AJ, Zhu X, Anand ATS, Nguyen CQ, Stiles L, Norheim F, Lang JM, Hui ST, Turcotte LP, Zhou Z. PMID: 34755487; PMCID: PMC8578881.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2. Nat Metab. 2021 11; 3(11):1552-1568. Chella Krishnan K, Vergnes L, Acín-Pérez R, Stiles L, Shum M, Ma L, Mouisel E, Pan C, Moore TM, Péterfy M, Romanoski CE, Reue K, Björkegren JLM, Laakso M, Liesa M, Lusis AJ. PMID: 34697471; PMCID: PMC8909918.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    12. Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives. Life (Basel). 2021 Sep 10; 11(9). Acin-Perez R, Benincá C, Shabane B, Shirihai OS, Stiles L. PMID: 34575097; PMCID: PMC8467772.
      View in: PubMed   Mentions: 5  
    13. Measuring CPT-1-mediated respiration in permeabilized cells and isolated mitochondria. STAR Protoc. 2021 09 17; 2(3):100687. Yang K, Doan MT, Stiles L, Divakaruni AS. PMID: 34401773; PMCID: PMC8348308.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    14. Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. Nat Commun. 2021 06 25; 12(1):3958. Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y. PMID: 34172753; PMCID: PMC8233314.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    15. ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity. Sci Transl Med. 2021 05 19; 13(594). Shum M, Shintre CA, Althoff T, Gutierrez V, Segawa M, Saxberg AD, Martinez M, Adamson R, Young MR, Faust B, Gharakhanian R, Su S, Chella Krishnan K, Mahdaviani K, Veliova M, Wolf DM, Ngo J, Nocito L, Stiles L, Abramson J, Lusis AJ, Hevener AL, Zoghbi ME, Carpenter EP, Liesa M. PMID: 34011630; PMCID: PMC8300486.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    16. Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling. EMBO Rep. 2020 12 03; 21(12):e49634. Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein AJ, Desousa BR, Acín-Pérez R, Petcherski A, Assali EA, Stiles L, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, Shirihai OS. PMID: 33275313; PMCID: PMC7726774.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    17. Measuring Mitochondrial Respiration in Previously Frozen Biological Samples. Curr Protoc Cell Biol. 2020 12; 89(1):e116. Osto C, Benador IY, Ngo J, Liesa M, Stiles L, Acin-Perez R, Shirihai OS. PMID: 33320426.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    18. Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics. Front Cell Dev Biol. 2020; 8:592035. Gonzalez-Ibanez AM, Ruiz LM, Jensen E, Echeverria CA, Romero V, Stiles L, Shirihai OS, Elorza AA. PMID: 33330472; PMCID: PMC7719720.
      View in: PubMed   Mentions: 10  
    19. Forces, fluxes, and fuels: tracking mitochondrial metabolism by integrating measurements of membrane potential, respiration, and metabolites. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C80-C91. Jones AE, Sheng L, Acevedo A, Veliova M, Shirihai OS, Stiles L, Divakaruni AS. PMID: 33147057; PMCID: PMC7846976.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge. Aging Cell. 2020 11; 19(11):e13166. Moore TM, Zhou Z, Strumwasser AR, Cohn W, Lin AJ, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Hoang AN, Widjaja K, Abrishami AD, Charugundla S, Stiles L, Whitelegge JP, Turcotte LP, Wanagat J, Hevener AL. PMID: 33049094; PMCID: PMC7681042.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    21. Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner. Cell Mol Gastroenterol Hepatol. 2021; 11(2):389-406. Chella Krishnan K, Floyd RR, Sabir S, Jayasekera DW, Leon-Mimila PV, Jones AE, Cortez AA, Shravah V, Péterfy M, Stiles L, Canizales-Quinteros S, Divakaruni AS, Huertas-Vazquez A, Lusis AJ. PMID: 32942044; PMCID: PMC7788245.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    22. Omega-3 fatty acids increase OXPHOS energy for immune therapy of Alzheimer disease patients. FASEB J. 2020 08; 34(8):9982-9994. Lau YCC, Ding JA, Simental A, Mirzoyan H, Lee W, Diamante G, Cely I, Tran M, Morselli M, Dang J, Kaczor-Urbanowicz KE, Sayre J, Stiles L, Yang X, Pellegrini M, Fiala M. PMID: 32614485.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice. Front Physiol. 2020; 11:690. Moore TM, Lin AJ, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQ, Yackly A, Mahata SK, Wanagat J, Stiles L, Turcotte LP, Crosbie RH, Zhou Z. PMID: 32636760; PMCID: PMC7317021.
      View in: PubMed   Mentions: 27  
    24. A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO J. 2020 07 01; 39(13):e104073. Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. PMID: 32432379; PMCID: PMC7327496.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    25. Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2020 01; 577(7791):E7. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31896820.
      View in: PubMed   Mentions:    Fields:    
    26. Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels. Diabetes. 2020 02; 69(2):131-145. Taddeo EP, Alsabeeh N, Baghdasarian S, Wikstrom JD, Ritou E, Sereda S, Erion K, Li J, Stiles L, Abdulla M, Swanson Z, Wilhelm JJ, Bellin MD, Kibbey RG, Liesa M, Shirihai OS. PMID: 31740442; PMCID: PMC6971491.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    27. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019 11; 575(7782):380-384. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31666695; PMCID: PMC7328016.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    28. Sex-specific metabolic functions of adipose Lipocalin-2. Mol Metab. 2019 12; 30:30-47. Chella Krishnan K, Sabir S, Shum M, Meng Y, Acín-Pérez R, Lang JM, Floyd RR, Vergnes L, Seldin MM, Fuqua BK, Jayasekera DW, Nand SK, Anum DC, Pan C, Stiles L, Péterfy M, Reue K, Liesa M, Lusis AJ. PMID: 31767179; PMCID: PMC6812340.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    29. Levocarnitine does not impair chemotherapy cytotoxicity against acute lymphoblastic leukemia. Leuk Lymphoma. 2020 02; 61(2):420-428. Sea JL, Orgel E, Chen T, Paszkiewicz RL, Krall AS, Oberley MJ, Stiles L, Mittelman SD. PMID: 31526067; PMCID: PMC7305023.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    30. Individual islet respirometry reveals functional diversity within the islet population of mice and human donors. Mol Metab. 2018 10; 16:150-159. Taddeo EP, Stiles L, Sereda S, Ritou E, Wolf DM, Abdullah M, Swanson Z, Wilhelm J, Bellin M, McDonald P, Caradonna K, Neilson A, Liesa M, Shirihai OS. PMID: 30098928; PMCID: PMC6157638.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    31. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab. 2018 09 04; 28(3):490-503.e7. Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN. PMID: 30043752; PMCID: PMC6125190.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    32. A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer Metab. 2018; 6:7. Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. PMID: 29988332; PMCID: PMC6022704.
      View in: PubMed   Mentions: 11  
    33. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 07; 18(7):1123-1138. Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. PMID: 28539390; PMCID: PMC5887905.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    34. Mitochondrial dynamics and morphology in beta-cells. Best Pract Res Clin Endocrinol Metab. 2012 Dec; 26(6):725-38. Stiles L, Shirihai OS. PMID: 23168275; PMCID: PMC5967392.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    35. A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. PLoS One. 2012; 7(5):e33023. Wikstrom JD, Sereda SB, Stiles L, Elorza A, Allister EM, Neilson A, Ferrick DA, Wheeler MB, Shirihai OS. PMID: 22606219; PMCID: PMC3351473.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    36. Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009 Oct; 58(10):2303-15. Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS. PMID: 19581419; PMCID: PMC2750232.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansAnimalsCells
    37. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 23; 27(2):433-46. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. PMID: 18200046; PMCID: PMC2234339.
      View in: PubMed   Mentions: 1384     Fields:    Translation:AnimalsCells
    38. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron. 2006 Sep 21; 51(6):811-22. Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS. PMID: 16982425.
      View in: PubMed   Mentions: 277     Fields:    Translation:AnimalsCells
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