Linsey Stiles

Title(s)Associate Adjunct Professor, Medicine
SchoolMedicine
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    Title(s)Associate Adjunct Professor, Molecular and Medical Pharmacology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions. Cell. 2026 Aug 04. Mil J, Soto JA, Krall AS, Peloggia J, Frigui S, Fong OS, Sathe L, Matulionis N, Day F, Stiles L, Montales KP, Azizad DJ, Gonzalez CE, Fazzari E, Li MX, Nano PR, Martija AA, Perez-Ramirez CA, Nguyen CV, Wick B, Ge W, Kan RL, Andrews MG, Haeussler M, Wells MF, Christofk HR, Bhaduri A. PMID: 42551423; PMCID: PMC13537306.
      View in: PubMed   Mentions:
    2. Truncating ASXL1 variants rewire cellular metabolism via mitochondrial pyruvate carrier repression. bioRxiv. 2026 Jul 17. Lin I, Reyes MSS, Krall AS, Vashist N, Sarkissian S, Matulionis N, Ning A, Stiles L, Russell BE, Medina PMB, Christofk HR, Arboleda VA. PMID: 42523271; PMCID: PMC13404655.
      View in: PubMed   Mentions:
    3. DGAT1-associated lipid-retinoid dysregulation correlates with metabolic impairment in the RPE of Stargardt disease. iScience. 2026 Aug 21; 29(8):116727. Dave A, Ng ESY, Jiang Z, Hu J, Tatang J, Paniagua A, Doeve J, Parikh S, Williams KJ, Stiles L, Radu RA. PMID: 42519008; PMCID: PMC13382123.
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    4. Considerations and best practices for respirometry. Cell Metab. 2026 Jun 02; 38(6):1093-1096. Ball AB, Stiles L, Divakaruni AS. PMID: 42229405.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77 pathway. Sci Adv. 2026 May 08; 12(19):eaec0795. Ma AM, Tran PH, Yang NL, Ngo J, Iwasaki H, Ren W, Livit S, Stiles L, Wang S, Ho T, Yim EY, Morrow N, Johnson MM, Cleary C, Zou K, Crosbie RH, Jiang Y, Shirihai OS, Wanagat J, Mahata S, Wohlschlegel JA, Hevener AL, Zhou Z. PMID: 42102209; PMCID: PMC13155292.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Early-Life Adversity and Mitochondrial Function: Comparing Cumulative Risk and Dimensional Models of Adversity. Biol Psychiatry. 2026 Apr 21. Cleveland S, Carroll JE, Montoya AK, Cha L, Stiles L, Sumner JA. PMID: 42025867.
      View in: PubMed   Mentions:    Fields:    
    7. Scalable workflows for high-throughput respirometry. Life Sci Alliance. 2026 Jun; 9(6). Osto CA, Mosharov EV, Rosenberg AM, Picard M, Stiles L, Shirihai O. PMID: 41986235; PMCID: PMC13084159.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Chronic cold exposure induces plasticity of mitochondrial calcium uptake in beige and brown fat of UCP1-deficient mice. bioRxiv. 2026 Mar 18. Chamorro CG, Pathuri S, Acin-Perez R, Chhan M, Milner MG, Ermolova N, Jones AE, Divakaruni AS, Stiles L, Hevener AL, Zhou Z, Shirihai OS, Kirichok Y, Bertholet AM. PMID: 41890101; PMCID: PMC13015561.
      View in: PubMed   Mentions:
    9. The malate-aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes. FEBS J. 2026 Aug; 293(15):4489-4507. Veliova M, Ferreira CM, Montales KP, Villalobos F, Brownstein AJ, Acín-Pérez R, Ferreira GS, Jones AE, Stiles L, Divakaruni AS, Liesa M, Shirihai OS, Oliveira MF. PMID: 41704162; PMCID: PMC13440609.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Disrupted energy metabolism is associated with retinal ganglion cell degeneration in autosomal dominant optic atrophy. Sci Adv. 2026 Feb 20; 12(8):eadx7815. Kang EY, Tseng YJ, Peng WH, Hung HC, Lin PH, Montales KP, Sherman E, Peregrin J, Wang EH, Kang C, Teng YC, Huang CY, Tsai CL, Chang IY, Chen J, Tezel G, He Y, Li TD, Stiles L, Shirihai O, Tsang SH, Lai CC, Tsai CN, Lin CS, Wang NK. PMID: 41706861; PMCID: PMC12915623.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Correction: Desai et al. TNFα-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice. Brain Sci.2022, 12, 900. Brain Sci. 2025 Oct 28; 15(11). Desai M, Stiles L, Torsoni AS, Torsoni MA, Shirihai OS, Ross MG. PMID: 41300255; PMCID: PMC12649908.
      View in: PubMed   Mentions:
    12. The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model. NPJ Parkinsons Dis. 2025 Oct 20; 11(1):301. Morais LH, Stiles L, Freeman M, Oguienko AD, Hoang JD, Ji J, Jones J, Quan B, Devine J, Bois JS, Chou TF, Trinh J, Picard M, Gradinaru V, Mazmanian SK. PMID: 41115949; PMCID: PMC12537952.
      View in: PubMed   Mentions:
    13. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy. Sci Adv. 2025 10 10; 11(41):eadw4153. Levi-D'Ancona E, Walker EM, Zhu J, Deng Y, Sidarala V, Stendahl AM, Reck EC, Henry-Kanarek BA, Lietzke AC, Chai B, Pasmooij MB, Hubers DL, Basrur V, Ghosh S, Stiles L, Nesvizhskii AI, Shirihai OS, Soleimanpour SA. PMID: 41061082; PMCID: PMC12507004.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation. Cell Rep. 2025 Oct 28; 44(10):116330. Sharma G, Gutierrez M, Jones AE, Kapoor S, Jaiswal AK, Neeb ZT, Rios A, Dorairaj P, Thaxton ML, Lin TL, Tran TM, Kabbani LES, Ritter AJ, Scherer GM, Sorrentino JP, Stiles L, Hoeve JT, Damoiseaux RD, Garg NK, Divakaruni AS, Sanford JR, Rao DS. PMID: 41015030; PMCID: PMC12593248.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and-independent mitophagy. bioRxiv. 2025 Sep 05. Levi-D'Ancona E, Walker EM, Zhu J, Deng Y, Sidarala V, Stendahl AM, Reck EC, Henry-Kanarek BA, Lietzke AC, Pasmooij MB, Hubers DL, Basrur V, Ghosh S, Stiles L, Nesvizhskii AI, Shirihai OS, Soleimanpour SA. PMID: 39974969; PMCID: PMC11838480.
      View in: PubMed   Mentions:
    16. The Malate-Aspartate Shuttle supports thermogenic lipid mobilization in brown adipocytes. bioRxiv. 2025 Aug 06. Veliova M, Ferreira CM, Montales K, Villalobos F, Brownstein AJ, Acín-Pérez R, Ferreira GS, Stiles L, Liesa M, Shirihai OS, Oliveira MF. PMID: 40799572; PMCID: PMC12340843.
      View in: PubMed   Mentions:
    17. Author Correction: A human brain map of mitochondrial respiratory capacity and diversity. Nature. 2025 Jun; 642(8067):E12. Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Junker A, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood MD, Boldrini M, Thiebaut de Schotten M, Picard M. PMID: 40404942.
      View in: PubMed   Mentions: 1     Fields:    
    18. A cold-inducible phospholipid-protein interaction in brown fat mitochondria optimizes thermogenic capacity. bioRxiv. 2025 May 18. Shimanaka Y, Tol MJ, Rocha-Roa C, Jellinek MJ, Cui L, Bender A, Bedard AH, Milner MG, Melillo B, Shoucri BM, Wong A, Williams KJ, Stiles L, Shum M, Weston TA, Cohn W, Whitelegge JP, Budin I, Bertholet AM, Cravatt BF, Young SG, Houten SM, Argmann C, Ford DA, Liesa M, Shirihai OS, Vanni S, Tontonoz P. PMID: 40463239; PMCID: PMC12132348.
      View in: PubMed   Mentions:
    19. 13C tracing in synaptosomes reveals that SGLT2 inhibition with dapagliflozin prevents metabolic deficits in the 5X-FAD model of Alzheimer's Disease. bioRxiv. 2025 May 03. Mekkittikul M, Zhu C, Danna BT, Zuo X, Rios A, Yang K, Villanueva M, Agarwal D, Castro D, Gu X, Strofs AR, Shirihai OS, Stiles L, Frautschy SA, Oscarsson J, Esterline RL, Cole GM, Divakaruni AS. PMID: 40654760; PMCID: PMC12247946.
      View in: PubMed   Mentions:
    20. A human brain map of mitochondrial respiratory capacity and diversity. Nature. 2025 05; 641(8063):749-758. Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Junker A, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood MD, Boldrini M, Thiebaut de Schotten M, Picard M. PMID: 40140564; PMCID: PMC12770858.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    21. Mitochondrial reactive oxygen species regulate acetyl-CoA flux between cytokine production and fatty acid synthesis in effector T cells. Cell Rep. 2025 Mar 25; 44(3):115430. Wu B, Woo JS, Hasiakos S, Pan C, Cokus S, Benincá C, Stiles L, Sun Z, Pellegrini M, Shirihai OS, Lusis AJ, Srikanth S, Gwack Y. PMID: 40088449; PMCID: PMC12007815.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate Transitions. bioRxiv. 2025 Mar 11. Mil J, Soto JA, Matulionis N, Krall A, Day F, Stiles L, Montales KP, Azizad DJ, Gonzalez CE, Nano PR, Martija AA, Perez-Ramirez CA, Nguyen CV, Kan RL, Andrews MG, Christofk HR, Bhaduri A. PMID: 40161647; PMCID: PMC11952424.
      View in: PubMed   Mentions:
    23. Derivation and Characterization of Isogenic OPA1 Mutant and Control Human Pluripotent Stem Cell Lines. Cells. 2025 01 17; 14(2). Pohl KA, Zhang X, Ji JJ, Stiles L, Sadun AA, Yang XJ. PMID: 39851566; PMCID: PMC11764107.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    24. Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation. EMBO Rep. 2025 02; 26(4):982-1002. Ball AB, Jones AE, Nguy?n KB, Rios A, Marx N, Hsieh WY, Yang K, Desousa BR, Kim KKO, Veliova M, Del Mundo ZM, Shirihai OS, Benincá C, Stiles L, Bensinger SJ, Divakaruni AS. PMID: 39753784; PMCID: PMC11850891.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    25. Metabolic regulation of RNA methylation by the m6A-reader IGF2BP3. bioRxiv. 2024 Nov 03. Sharma G, Gutierrez M, Jones AE, Jaiswal AK, Neeb ZT, Rios A, Thaxton ML, Lin TL, Tran TM, Kabbani LES, Ritter AJ, Stiles L, Hoeve JT, Divakaruni AS, Sanford JR, Rao DS. PMID: 39554138; PMCID: PMC11565949.
      View in: PubMed   Mentions:
    26. A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction. Cell Rep Med. 2024 11 19; 5(11):101795. Li S, Tao B, Wan J, Montecino-Rodriguez E, Wang P, Ma F, Sun B, Gu Y, Ramadoss S, Su L, Sun Q, Hoeve JT, Stiles L, Collins J, van Dam RM, Tamboline M, Taschereau R, Shirihai O, Kitchen DB, Pellegrini M, Graeber T, Dorshkind K, Xu S, Deb A. PMID: 39454569; PMCID: PMC11604407.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    27. Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respiration. bioRxiv. 2024 May 14. Ball AB, Jones AE, Nguy?n KB, Rios A, Marx N, Hsieh WY, Yang K, Desousa BR, Kim KKO, Veliova M, Del Mundo ZM, Shirihai OS, Benincá C, Stiles L, Bensinger SJ, Divakaruni AS. PMID: 38798678; PMCID: PMC11118427.
      View in: PubMed   Mentions:
    28. Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria. Sci Adv. 2024 04 05; 10(14):eadl0389. Zhou Z, Ma A, Moore TM, Wolf DM, Yang N, Tran P, Segawa M, Strumwasser AR, Ren W, Fu K, Wanagat J, van der Bliek AM, Crosbie-Watson R, Liesa M, Stiles L, Acin-Perez R, Mahata S, Shirihai O, Goodarzi MO, Handzlik M, Metallo CM, Walker DW, Hevener AL. PMID: 38569044; PMCID: PMC10990287.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity. Res Sq. 2024 Mar 22. Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood M, Boldrini M, Thiebaut de Schotten M, Picard M. PMID: 38562777; PMCID: PMC10984021.
      View in: PubMed   Mentions:
    30. A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity. bioRxiv. 2024 Mar 07. Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood M, Boldrini M, de Schotten MT, Picard M. PMID: 38496679; PMCID: PMC10942385.
      View in: PubMed   Mentions: 1  
    31. The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. J Biol Chem. 2024 03; 300(3):105702. Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. PMID: 38301896; PMCID: PMC10910128.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    32. Sex differences in the neuronal transcriptome and synaptic mitochondrial function in the cerebral cortex of a multiple sclerosis model. Front Neurol. 2023; 14:1268411. Itoh N, Itoh Y, Stiles L, Voskuhl R. PMID: 38020654; PMCID: PMC10654219.
      View in: PubMed   Mentions: 3  
    33. Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1. Mol Cancer Ther. 2023 11 01; 22(11):1290-1303. Schwarzer A, Oliveira M, Kleppa MJ, Slattery SD, Anantha A, Cooper A, Hannink M, Schambach A, Dörrie A, Kotlyarov A, Gaestel M, Hembrough T, Levine J, Luther M, Stocum M, Stiles L, Weinstock DM, Liesa M, Kostura MJ. PMID: 37643767; PMCID: PMC10723637.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    34. Regulation of Postnatal Cardiomyocyte Maturation by an RNA Splicing Regulator RBFox1. Circulation. 2023 10 17; 148(16):1263-1266. Huang J, Lee JZ, Rau CD, Pezhouman A, Yokota T, Miwa H, Feldman M, Kong TK, Yang Z, Tay WT, Pushkarsky I, Kim K, Parikh SS, Udani S, Soh BS, Gao C, Stiles L, Shirihai OS, Knollmann BC, Ardehali R, Di Carlo D, Wang Y. PMID: 37844148; PMCID: PMC10593507.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    35. The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. bioRxiv. 2023 Aug 16. Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. PMID: 37645724; PMCID: PMC10461965.
      View in: PubMed   Mentions:
    36. Calculation of ATP production rates using the Seahorse XF Analyzer. EMBO Rep. 2023 10 09; 24(10):e56380. Desousa BR, Kim KK, Jones AE, Ball AB, Hsieh WY, Swain P, Morrow DH, Brownstein AJ, Ferrick DA, Shirihai OS, Neilson A, Nathanson DA, Rogers GW, Dranka BP, Murphy AN, Affourtit C, Bensinger SJ, Stiles L, Romero N, Divakaruni AS. PMID: 37548091; PMCID: PMC10561364.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    37. Dapagliflozin prevents abdominal visceral and subcutaneous adipose tissue dysfunction in the insulin-resistant canine model. Obesity (Silver Spring). 2023 07; 31(7):1798-1811. Kabir M, Bergman RN, Porter J, Stefanovski D, Paszkiewicz RL, Piccinini F, Woolcott OO, Yang H, Gopaul VS, Stiles L, Kolka CM. PMID: 37221655; PMCID: PMC10981466.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    38. Reduced methionine synthase expression results in uracil accumulation in mitochondrial DNA and impaired oxidative capacity. PNAS Nexus. 2023 Apr; 2(4):pgad105. Heyden KE, Fiddler JL, Xiu Y, Malysheva OV, Handzlik MK, Phinney WN, Stiles L, Stabler SP, Metallo CM, Caudill MA, Field MS. PMID: 37077889; PMCID: PMC10109189.
      View in: PubMed   Mentions: 9  
    39. Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Nature. 2023 03; 615(7953):712-719. Han M, Bushong EA, Segawa M, Tiard A, Wong A, Brady MR, Momcilovic M, Wolf DM, Zhang R, Petcherski A, Madany M, Xu S, Lee JT, Poyurovsky MV, Olszewski K, Holloway T, Gomez A, John MS, Dubinett SM, Koehler CM, Shirihai OS, Stiles L, Lisberg A, Soatto S, Sadeghi S, Ellisman MH, Shackelford DB. PMID: 36922590; PMCID: PMC10033418.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    40. Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA. EMBO J. 2023 06 01; 42(11):e111901. Ngo J, Choi DW, Stanley IA, Stiles L, Molina AJA, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, Miller N, Baghdasarian S, Kim-Vasquez D, Jones AE, Roach B, Gutierrez V, Erion K, Divakaruni AS, Liesa M, Danial NN, Shirihai OS. PMID: 36917141; PMCID: PMC10233380.
      View in: PubMed   Mentions: 92     Fields:    Translation:Cells
    41. A novel approach to measure complex V ATP hydrolysis in frozen cell lysates and tissue homogenates. Life Sci Alliance. 2023 04; 6(4). Fernandez-Del-Rio L, Benincá C, Villalobos F, Shu C, Stiles L, Liesa M, Divakaruni AS, Acin-Perez R, Shirihai OS. PMID: 36918278; PMCID: PMC10019470.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    42. Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies. EMBO J. 2023 05 15; 42(10):e111699. Acin-Perez R, Benincá C, Fernandez Del Rio L, Shu C, Baghdasarian S, Zanette V, Gerle C, Jiko C, Khairallah R, Khan S, Rincon Fernandez Pacheco D, Shabane B, Erion K, Masand R, Dugar S, Ghenoiu C, Schreiner G, Stiles L, Liesa M, Shirihai OS. PMID: 36912136; PMCID: PMC10183817.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    43. Isolation of Mitochondria from Mouse Tissues for Functional Analysis. Methods Mol Biol. 2023; 2675:77-96. Acín-Pérez R, Montales KP, Nguyen KB, Brownstein AJ, Stiles L, Divakaruni AS. PMID: 37258757; PMCID: PMC11105805.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    44. Distinct Patterns of Gene Expression Changes in the Colon and Striatum of Young Mice Overexpressing Alpha-Synuclein Support Parkinson's Disease as a Multi-System Process. J Parkinsons Dis. 2023; 13(7):1127-1147. Videlock EJ, Hatami A, Zhu C, Kawaguchi R, Chen H, Khan T, Yehya AHS, Stiles L, Joshi S, Hoffman JM, Law KM, Rankin CR, Chang L, Maidment NT, John V, Geschwind DH, Pothoulakis C. PMID: 37638450; PMCID: PMC10657720.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    45. Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas. Nat Commun. 2022 11 17; 13(1):7037. Do Rhee K, Wang Y, Ten Hoeve J, Stiles L, Nguyen TTT, Zhang X, Vergnes L, Reue K, Shirihai O, Bok D, Yang XJ. PMID: 36396639; PMCID: PMC9672129.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    46. Correction: Vitamin B3, nicotinamide, enhances mitochondrial metabolism to promote differentiation of the retinal pigment epithelium. J Biol Chem. 2022 Oct; 298(10):102493. Hazim RA, Paniagua AE, Tang L, Yang K, Kim KKO, Stiles L, Divakaruni AS, Williams DS. PMID: 36191577; PMCID: PMC9531174.
      View in: PubMed   Mentions:    Fields:    
    47. Vitamin B3, nicotinamide, enhances mitochondrial metabolism to promote differentiation of the retinal pigment epithelium. J Biol Chem. 2022 09; 298(9):102286. Hazim RA, Paniagua AE, Tang L, Yang K, Kim KKO, Stiles L, Divakaruni AS, Williams DS. PMID: 35868562; PMCID: PMC9396405.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    48. TNFα-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice. Brain Sci. 2022 Jul 09; 12(7). Desai M, Stiles L, Torsoni AS, Torsoni MA, Shirihai OS, Ross MG. PMID: 35884707; PMCID: PMC9316209.
      View in: PubMed   Mentions: 4  
    49. Characterizing the metabolic profile of dexamethasone treated human trabecular meshwork cells. Exp Eye Res. 2022 01; 214:108888. Graybeal K, Sanchez L, Zhang C, Stiles L, Zheng JJ. PMID: 34896106; PMCID: PMC9272781.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    50. Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance. Mol Metab. 2022 01; 55:101403. Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M. PMID: 34823065; PMCID: PMC8689243.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    51. Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice. Physiol Rep. 2021 11; 9(21):e15068. Moore TM, Terrazas A, Strumwasser AR, Lin AJ, Zhu X, Anand ATS, Nguyen CQ, Stiles L, Norheim F, Lang JM, Hui ST, Turcotte LP, Zhou Z. PMID: 34755487; PMCID: PMC8578881.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    52. Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2. Nat Metab. 2021 11; 3(11):1552-1568. Chella Krishnan K, Vergnes L, Acín-Pérez R, Stiles L, Shum M, Ma L, Mouisel E, Pan C, Moore TM, Péterfy M, Romanoski CE, Reue K, Björkegren JLM, Laakso M, Liesa M, Lusis AJ. PMID: 34697471; PMCID: PMC8909918.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    53. Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives. Life (Basel). 2021 Sep 10; 11(9). Acin-Perez R, Benincá C, Shabane B, Shirihai OS, Stiles L. PMID: 34575097; PMCID: PMC8467772.
      View in: PubMed   Mentions: 21  
    54. Measuring CPT-1-mediated respiration in permeabilized cells and isolated mitochondria. STAR Protoc. 2021 09 17; 2(3):100687. Yang K, Doan MT, Stiles L, Divakaruni AS. PMID: 34401773; PMCID: PMC8348308.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    55. Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. Nat Commun. 2021 06 25; 12(1):3958. Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y. PMID: 34172753; PMCID: PMC8233314.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    56. ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity. Sci Transl Med. 2021 05 19; 13(594). Shum M, Shintre CA, Althoff T, Gutierrez V, Segawa M, Saxberg AD, Martinez M, Adamson R, Young MR, Faust B, Gharakhanian R, Su S, Chella Krishnan K, Mahdaviani K, Veliova M, Wolf DM, Ngo J, Nocito L, Stiles L, Abramson J, Lusis AJ, Hevener AL, Zoghbi ME, Carpenter EP, Liesa M. PMID: 34011630; PMCID: PMC8300486.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    57. Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling. EMBO Rep. 2020 12 03; 21(12):e49634. Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein AJ, Desousa BR, Acín-Pérez R, Petcherski A, Assali EA, Stiles L, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, Shirihai OS. PMID: 33275313; PMCID: PMC7726774.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    58. Measuring Mitochondrial Respiration in Previously Frozen Biological Samples. Curr Protoc Cell Biol. 2020 12; 89(1):e116. Osto C, Benador IY, Ngo J, Liesa M, Stiles L, Acin-Perez R, Shirihai OS. PMID: 33320426.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    59. Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics. Front Cell Dev Biol. 2020; 8:592035. Gonzalez-Ibanez AM, Ruiz LM, Jensen E, Echeverria CA, Romero V, Stiles L, Shirihai OS, Elorza AA. PMID: 33330472; PMCID: PMC7719720.
      View in: PubMed   Mentions: 23  
    60. Forces, fluxes, and fuels: tracking mitochondrial metabolism by integrating measurements of membrane potential, respiration, and metabolites. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C80-C91. Jones AE, Sheng L, Acevedo A, Veliova M, Shirihai OS, Stiles L, Divakaruni AS. PMID: 33147057; PMCID: PMC7846976.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    61. Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge. Aging Cell. 2020 11; 19(11):e13166. Moore TM, Zhou Z, Strumwasser AR, Cohn W, Lin AJ, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Hoang AN, Widjaja K, Abrishami AD, Charugundla S, Stiles L, Whitelegge JP, Turcotte LP, Wanagat J, Hevener AL. PMID: 33049094; PMCID: PMC7681042.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    62. Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner. Cell Mol Gastroenterol Hepatol. 2021; 11(2):389-406. Chella Krishnan K, Floyd RR, Sabir S, Jayasekera DW, Leon-Mimila PV, Jones AE, Cortez AA, Shravah V, Péterfy M, Stiles L, Canizales-Quinteros S, Divakaruni AS, Huertas-Vazquez A, Lusis AJ. PMID: 32942044; PMCID: PMC7788245.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    63. Omega-3 fatty acids increase OXPHOS energy for immune therapy of Alzheimer disease patients. FASEB J. 2020 08; 34(8):9982-9994. Lau YCC, Ding JA, Simental A, Mirzoyan H, Lee W, Diamante G, Cely I, Tran M, Morselli M, Dang J, Kaczor-Urbanowicz KE, Sayre J, Stiles L, Yang X, Pellegrini M, Fiala M. PMID: 32614485.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    64. Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice. Front Physiol. 2020; 11:690. Moore TM, Lin AJ, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQ, Yackly A, Mahata SK, Wanagat J, Stiles L, Turcotte LP, Crosbie RH, Zhou Z. PMID: 32636760; PMCID: PMC7317021.
      View in: PubMed   Mentions: 63  
    65. A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO J. 2020 07 01; 39(13):e104073. Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. PMID: 32432379; PMCID: PMC7327496.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    66. Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2020 01; 577(7791):E7. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31896820.
      View in: PubMed   Mentions: 1     Fields:    
    67. Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels. Diabetes. 2020 02; 69(2):131-145. Taddeo EP, Alsabeeh N, Baghdasarian S, Wikstrom JD, Ritou E, Sereda S, Erion K, Li J, Stiles L, Abdulla M, Swanson Z, Wilhelm JJ, Bellin MD, Kibbey RG, Liesa M, Shirihai OS. PMID: 31740442; PMCID: PMC6971491.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    68. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019 11; 575(7782):380-384. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31666695; PMCID: PMC7328016.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    69. Sex-specific metabolic functions of adipose Lipocalin-2. Mol Metab. 2019 12; 30:30-47. Chella Krishnan K, Sabir S, Shum M, Meng Y, Acín-Pérez R, Lang JM, Floyd RR, Vergnes L, Seldin MM, Fuqua BK, Jayasekera DW, Nand SK, Anum DC, Pan C, Stiles L, Péterfy M, Reue K, Liesa M, Lusis AJ. PMID: 31767179; PMCID: PMC6812340.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    70. Levocarnitine does not impair chemotherapy cytotoxicity against acute lymphoblastic leukemia. Leuk Lymphoma. 2020 02; 61(2):420-428. Sea JL, Orgel E, Chen T, Paszkiewicz RL, Krall AS, Oberley MJ, Stiles L, Mittelman SD. PMID: 31526067; PMCID: PMC7305023.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    71. Individual islet respirometry reveals functional diversity within the islet population of mice and human donors. Mol Metab. 2018 10; 16:150-159. Taddeo EP, Stiles L, Sereda S, Ritou E, Wolf DM, Abdullah M, Swanson Z, Wilhelm J, Bellin M, McDonald P, Caradonna K, Neilson A, Liesa M, Shirihai OS. PMID: 30098928; PMCID: PMC6157638.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    72. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab. 2018 09 04; 28(3):490-503.e7. Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN. PMID: 30043752; PMCID: PMC6125190.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    73. A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer Metab. 2018; 6:7. Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. PMID: 29988332; PMCID: PMC6022704.
      View in: PubMed   Mentions: 17  
    74. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 07; 18(7):1123-1138. Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. PMID: 28539390; PMCID: PMC5887905.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    75. Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors. Toxicol Sci. 2017 01; 155(1):61-74. Woodhead JL, Brock WJ, Roth SE, Shoaf SE, Brouwer KL, Church R, Grammatopoulos TN, Stiles L, Siler SQ, Howell BA, Mosedale M, Watkins PB, Shoda LK. PMID: 27655350; PMCID: PMC5216653.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    76. Mitochondrial dynamics and morphology in beta-cells. Best Pract Res Clin Endocrinol Metab. 2012 Dec; 26(6):725-38. Stiles L, Shirihai OS. PMID: 23168275; PMCID: PMC5967392.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    77. A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. PLoS One. 2012; 7(5):e33023. Wikstrom JD, Sereda SB, Stiles L, Elorza A, Allister EM, Neilson A, Ferrick DA, Wheeler MB, Shirihai OS. PMID: 22606219; PMCID: PMC3351473.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    78. Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009 Oct; 58(10):2303-15. Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS. PMID: 19581419; PMCID: PMC2750232.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansAnimalsCells
    79. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 23; 27(2):433-46. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. PMID: 18200046; PMCID: PMC2234339.
      View in: PubMed   Mentions: 1660     Fields:    Translation:AnimalsCells
    80. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron. 2006 Sep 21; 51(6):811-22. Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS. PMID: 16982425.
      View in: PubMed   Mentions: 302     Fields:    Translation:AnimalsCells
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