Shili Xu

Title(s)Assistant Adjunct Professor, Molecular and Medical Pharmacology
SchoolMedicine
ORCID ORCID Icon0000-0002-4933-8673 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Southern California, Los AngelesPh.D.05/2013Pharmaceutical Sciences
    Peking University, BeijingB.S.06/2007Biological Sciences
    Peking University, BeijingB.S.06/2007Economics
    Collapse Awards and Honors
    Society of Nuclear Medicine and Molecular Imaging2020The Alavi-Mandell Award
    The Hirshberg Foundation2018The Hirshberg Foundation Seed Grant Award
    UCLA2017Best Postdoctoral Research Presentation Award
    US Department of Defense2016The Horizon Award
    UCLA2015Best Research Poster Presentation Award
    University of Southern California2013Phi Kappa Phi Student Recognition Award
    University of Southern California2013The 1st Prize in Annual Graduate STEM Research Competition
    University of Southern California2013GPSAW Award for Best Graduate Research
    University of Southern California2013Outstanding Research Assistant Award
    University of Southern California2012The 1st Prize in Research Poster Presentation
    University of Southern California2009Outstanding Teaching Assistant Award
    Peking University2006President’s Undergraduate Research Fellowship
    Peking University2005Jia-Li Scholarship
    Peking University2004Guang-Hua Scholarship

    Collapse Overview 
    Collapse Overview
    My research team focuses on the development of in vivo state-of-the-art molecular imaging technologies including positron emission tomography (PET), single-photon emission computed tomography (SPECT), computed tomography (CT), magnetic resonance imaging (MRI) and optical (fluorescence and bioluminescence) imaging. We integrate and apply these technologies for non-invasive assessment of cancer, immune response, neurological disorders, cardiology, and associated biology, as well as preclinical probe and drug development in small animal models. We have developed a broad spectrum of PET probes and reporter genes to preclinically image cell metabolism, monitor cell trafficking and activation, disease progression, and profile drug pharmacokinetic/pharmacodynamics/biodistribution and tracer kinetics. Combining PET and SPECT imaging, my team develops translational theranostic radiopharmaceuticals for cancer management.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Real-time resolution studies of the regulation of lactate production by hexokinases binding to mitochondria in single cells. PLoS One. 2024; 19(3):e0300150. John S, Calmettes G, Xu S, Ribalet B. PMID: 38457438; PMCID: PMC10923494.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. 18F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma. Chem Sci. 2023 Dec 06; 14(47):13825-13831. Narayanam MK, Tsang JE, Xu S, Nathanson DA, Murphy JM. PMID: 38075671; PMCID: PMC10699577.
      View in: PubMed   Mentions: 1  
    3. Real-time resolution studies of the regulation of pyruvate-dependent lactate metabolism by hexokinases in single cells. PLoS One. 2023; 18(11):e0286660. John S, Calmettes G, Xu S, Ribalet B. PMID: 37917627; PMCID: PMC10621844.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance. Neuro Oncol. 2023 11 02; 25(11):1989-2000. Bailleul J, Ruan Y, Abdulrahman L, Scott AJ, Yazal T, Sung D, Park K, Hoang H, Nathaniel J, Chu FI, Palomera D, Sehgal A, Tsang JE, Nathanson DA, Xu S, Park JO, Ten Hoeve J, Bhat K, Qi N, Kornblum HI, Schaue D, McBride WH, Lyssiotis CA, Wahl DR, Vlashi E. PMID: 37279645; PMCID: PMC10628945.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Nature. 2023 03; 615(7953):712-719. Han M, Bushong EA, Segawa M, Tiard A, Wong A, Brady MR, Momcilovic M, Wolf DM, Zhang R, Petcherski A, Madany M, Xu S, Lee JT, Poyurovsky MV, Olszewski K, Holloway T, Gomez A, John MS, Dubinett SM, Koehler CM, Shirihai OS, Stiles L, Lisberg A, Soatto S, Sadeghi S, Ellisman MH, Shackelford DB. PMID: 36922590; PMCID: PMC10033418.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    6. Poly(trehalose methacrylate) as an Excipient for Insulin Stabilization: Mechanism and Safety. ACS Appl Mater Interfaces. 2022 Aug 24; 14(33):37410-37423. Gelb MB, Messina KMM, Vinciguerra D, Ko JH, Collins J, Tamboline M, Xu S, Ibarrondo FJ, Maynard HD. PMID: 35968684; PMCID: PMC9412841.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    7. Low-dose exposure to PBDE disrupts genomic integrity and innate immunity in mammary tissue. Front Genet. 2022; 13:904607. Lamkin DM, Chen S, Bradshaw KP, Xu S, Faull KF, Sloan EK, Cole SW. PMID: 36035174; PMCID: PMC9413140.
      View in: PubMed   Mentions: 6  
    8. Giant Magnetoelastic Effect Enabled Stretchable Sensor for Self-Powered Biomonitoring. ACS Nano. 2022 Apr 26; 16(4):6013-6022. Zhao X, Chen G, Zhou Y, Nashalian A, Xu J, Tat T, Song Y, Libanori A, Xu S, Li S, Chen J. PMID: 35417654.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsPHPublic Health
    9. Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities. Mol Ther Methods Clin Dev. 2022 Jun 09; 25:278-296. Khoja S, Lambert J, Nitzahn M, Eliav A, Zhang Y, Tamboline M, Le CT, Nasser E, Li Y, Patel P, Zhuravka I, Lueptow LM, Tkachyova I, Xu S, Nissim I, Schulze A, Lipshutz GS. PMID: 35505663; PMCID: PMC9051621.
      View in: PubMed   Mentions: 1  
    10. Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients. Proc Natl Acad Sci U S A. 2021 03 16; 118(11). Yang L, Yan X, Chen J, Zhan Q, Hua Y, Xu S, Li Z, Wang Z, Dong Y, Zuo D, Xue M, Tang Y, Herschman HR, Lu S, Shi Q, Wei W. PMID: 33836566; PMCID: PMC7980452.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    11. Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer. Sci Rep. 2020 01 15; 10(1):377. Li R, Ong SL, Tran LM, Jing Z, Liu B, Park SJ, Huang ZL, Walser TC, Heinrich EL, Lee G, Salehi-Rad R, Crosson WP, Pagano PC, Paul MK, Xu S, Herschman H, Krysan K, Dubinett S. PMID: 31941995; PMCID: PMC6962381.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    12. Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression. Theranostics. 2020; 10(2):829-840. Kim SS, Xu S, Cui J, Poddar S, Le TM, Hayrapetyan H, Li L, Wu N, Moore AM, Zhou L, Yu AC, Dann AM, Elliott IA, Abt ER, Kim W, Dawson DW, Radu CG, Donahue TR. PMID: 31903153; PMCID: PMC6929997.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    13. Comparison of the Efficacy and Sensitivity of Alternative PET Reporter Gene/PET Reporter Probe Systems That Minimize Biological Variables. Methods Mol Biol. 2020; 2126:177-190. Xu S, Herschman HR. PMID: 32112389.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism. Cell Chem Biol. 2020 02 20; 27(2):197-205.e6. Abt ER, Rosser EW, Durst MA, Lok V, Poddar S, Le TM, Cho A, Kim W, Wei L, Song J, Capri JR, Xu S, Wu N, Slavik R, Jung ME, Damoiseaux R, Czernin J, Donahue TR, Lavie A, Radu CG. PMID: 31734178; PMCID: PMC7035983.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    15. A Tumor Agnostic Therapeutic Strategy for Hexokinase 1-Null/Hexokinase 2-Positive Cancers. Cancer Res. 2019 Dec 01; 79(23):5907-5914. Xu S, Herschman HR. PMID: 31434645.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    16. Identification, synthesis and evaluation of CSF1R inhibitors using fragment based drug design. Comput Biol Chem. 2019 Jun; 80:374-383. Machiraju PK, Yedla P, Gubbala SP, Bohari T, Abdul JKV, Xu S, Patel R, Chittireddy VRR, Boppana K, Jagarlapudi SARP, Neamati N, Syed R, Amanchy R. PMID: 31103918.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    17. Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes. Theranostics. 2019; 9(8):2282-2298. Xu S, Liu Y, Yang K, Wang H, Shergalis A, Kyani A, Bankhead A, Tamura S, Yang S, Wang X, Wang CC, Rehemtulla A, Ljungman M, Neamati N. PMID: 31149044; PMCID: PMC6531306.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    18. Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):6842-6847. Elliott IA, Dann AM, Xu S, Kim SS, Abt ER, Kim W, Poddar S, Moore A, Zhou L, Williams JL, Capri JR, Ghukasyan R, Matsumura C, Tucker DA, Armstrong WR, Cabebe AE, Wu N, Li L, Le TM, Radu CG, Donahue TR. PMID: 30894490; PMCID: PMC6452719.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    19. An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1-HK2+ Multiple Myeloma. Cancer Res. 2019 05 15; 79(10):2748-2760. Xu S, Zhou T, Doh HM, Trinh KR, Catapang A, Lee JT, Braas D, Bayley NA, Yamada RE, Vasuthasawat A, Sasine JP, Timmerman JM, Larson SM, Kim Y, MacLeod AR, Morrison SL, Herschman HR. PMID: 30885978; PMCID: PMC6522331.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    20. Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling. Cell Rep. 2018 12 04; 25(10):2919-2934.e8. Argus JP, Wilks MQ, Zhou QD, Hsieh WY, Khialeeva E, Hoi XP, Bui V, Xu S, Yu AK, Wang ES, Herschman HR, Williams KJ, Bensinger SJ. PMID: 30517876; PMCID: PMC6432944.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. Hexokinase 2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin. J Nucl Med. 2018 Jun 07. Xu S, Catapang A, Doh HM, Bayley NA, Lee JT, Braas D, Graeber TG, Herschman HR. PMID: 29880505; PMCID: PMC8833855.
      View in: PubMed   Mentions: 8     Fields:    
    22. Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Nat Commun. 2016 Apr 29; 7:11457. Krall AS, Xu S, Graeber TG, Braas D, Christofk HR. PMID: 27126896; PMCID: PMC4855534.
      View in: PubMed   Mentions: 246     Fields:    Translation:HumansCells
    23. A review on PARP1 inhibitors: Pharmacophore modeling, virtual and biological screening studies to identify novel PARP1 inhibitors. Curr Top Med Chem. 2014; 14(17):2020-30. Singh SS, Sarma JA, Narasu L, Dayam R, Xu S, Neamati N. PMID: 25262797.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Protein disulfide isomerase: a promising target for cancer therapy. Drug Discov Today. 2014 Mar; 19(3):222-40. Xu S, Sankar S, Neamati N. PMID: 24184531.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimalsCells
    25. gp130: a promising drug target for cancer therapy. Expert Opin Ther Targets. 2013 Nov; 17(11):1303-28. Xu S, Neamati N. PMID: 24099136.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    26. Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma. PLoS One. 2013; 8(7):e69484. Adisetiyo H, Liang M, Liao CP, Aycock-Williams A, Cohen MB, Xu S, Neamati N, Conway EM, Cheng CY, Nikitin AY, Roy-Burman P. PMID: 23936028; PMCID: PMC3729965.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    27. Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues. Bioorg Med Chem Lett. 2013 Sep 15; 23(18):5135-9. Saha S, Reddy ChV, Xu S, Sankar S, Neamati N, Patro B. PMID: 23927972.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol Cancer Ther. 2013 Jun; 12(6):937-49. Xu S, Grande F, Garofalo A, Neamati N. PMID: 23536726.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    29. Stabilization of MDA-7/IL-24 for colon cancer therapy. Cancer Lett. 2013 Jul 28; 335(2):421-30. Xu S, Oshima T, Imada T, Masuda M, Debnath B, Grande F, Garofalo A, Neamati N. PMID: 23481022.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    30. Small molecule inhibitors of CXCR4. Theranostics. 2013; 3(1):47-75. Debnath B, Xu S, Grande F, Garofalo A, Neamati N. PMID: 23382786; PMCID: PMC3563081.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimals
    31. Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties. J Med Chem. 2012 Nov 26; 55(22):9492-509. Zeng LF, Wang Y, Kazemi R, Xu S, Xu ZL, Sanchez TW, Yang LM, Debnath B, Odde S, Xie H, Zheng YT, Ding J, Neamati N, Long YQ. PMID: 23098137.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    32. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16348-53. Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA, Neamati N. PMID: 22988091; PMCID: PMC3479552.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    33. Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. J Med Chem. 2012 Aug 09; 55(15):6645-68. Debnath B, Xu S, Neamati N. PMID: 22650325.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    34. Small-molecule inhibitors of p53-MDM2 interaction: the 2006-2010 update. Curr Pharm Des. 2011; 17(6):536-59. Millard M, Pathania D, Grande F, Xu S, Neamati N. PMID: 21391905.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    35. Biological evaluation of paclitaxel-peptide conjugates as a model for MMP2-targeted drug delivery. Cancer Biol Ther. 2010 Feb; 9(3):192-203. Yamada R, Kostova MB, Anchoori RK, Xu S, Neamati N, Khan SR. PMID: 20023432.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    36. A chemical lipid modification of recombinant preS antigen to study the mechanism of HBV attachment to the host cell. J Biotechnol. 2008 Oct 10; 137(1-4):8-13. Chen B, Lian M, Xu S, Luo M, Zheng X. PMID: 18675858.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
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