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Real-time resolution studies of the regulation of lactate production by hexokinases binding to mitochondria in single cells. PLoS One. 2024; 19(3):e0300150.
John S, Calmettes G, Xu S, Ribalet B. PMID: 38457438; PMCID: PMC10923494.
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HumansCells
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18F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma. Chem Sci. 2023 Dec 06; 14(47):13825-13831.
Narayanam MK, Tsang JE, Xu S, Nathanson DA, Murphy JM. PMID: 38075671; PMCID: PMC10699577.
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1
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Real-time resolution studies of the regulation of pyruvate-dependent lactate metabolism by hexokinases in single cells. PLoS One. 2023; 18(11):e0286660.
John S, Calmettes G, Xu S, Ribalet B. PMID: 37917627; PMCID: PMC10621844.
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2 Fields:
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HumansCells
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M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance. Neuro Oncol. 2023 11 02; 25(11):1989-2000.
Bailleul J, Ruan Y, Abdulrahman L, Scott AJ, Yazal T, Sung D, Park K, Hoang H, Nathaniel J, Chu FI, Palomera D, Sehgal A, Tsang JE, Nathanson DA, Xu S, Park JO, Ten Hoeve J, Bhat K, Qi N, Kornblum HI, Schaue D, McBride WH, Lyssiotis CA, Wahl DR, Vlashi E. PMID: 37279645; PMCID: PMC10628945.
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PubMed Mentions:
5 Fields:
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HumansCells
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Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Nature. 2023 03; 615(7953):712-719.
Han M, Bushong EA, Segawa M, Tiard A, Wong A, Brady MR, Momcilovic M, Wolf DM, Zhang R, Petcherski A, Madany M, Xu S, Lee JT, Poyurovsky MV, Olszewski K, Holloway T, Gomez A, John MS, Dubinett SM, Koehler CM, Shirihai OS, Stiles L, Lisberg A, Soatto S, Sadeghi S, Ellisman MH, Shackelford DB. PMID: 36922590; PMCID: PMC10033418.
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27 Fields:
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HumansCells
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Poly(trehalose methacrylate) as an Excipient for Insulin Stabilization: Mechanism and Safety. ACS Appl Mater Interfaces. 2022 Aug 24; 14(33):37410-37423.
Gelb MB, Messina KMM, Vinciguerra D, Ko JH, Collins J, Tamboline M, Xu S, Ibarrondo FJ, Maynard HD. PMID: 35968684; PMCID: PMC9412841.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Low-dose exposure to PBDE disrupts genomic integrity and innate immunity in mammary tissue. Front Genet. 2022; 13:904607.
Lamkin DM, Chen S, Bradshaw KP, Xu S, Faull KF, Sloan EK, Cole SW. PMID: 36035174; PMCID: PMC9413140.
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6
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Giant Magnetoelastic Effect Enabled Stretchable Sensor for Self-Powered Biomonitoring. ACS Nano. 2022 Apr 26; 16(4):6013-6022.
Zhao X, Chen G, Zhou Y, Nashalian A, Xu J, Tat T, Song Y, Libanori A, Xu S, Li S, Chen J. PMID: 35417654.
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9 Fields:
Translation:
HumansAnimalsPHPublic Health
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Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities. Mol Ther Methods Clin Dev. 2022 Jun 09; 25:278-296.
Khoja S, Lambert J, Nitzahn M, Eliav A, Zhang Y, Tamboline M, Le CT, Nasser E, Li Y, Patel P, Zhuravka I, Lueptow LM, Tkachyova I, Xu S, Nissim I, Schulze A, Lipshutz GS. PMID: 35505663; PMCID: PMC9051621.
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1
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Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients. Proc Natl Acad Sci U S A. 2021 03 16; 118(11).
Yang L, Yan X, Chen J, Zhan Q, Hua Y, Xu S, Li Z, Wang Z, Dong Y, Zuo D, Xue M, Tang Y, Herschman HR, Lu S, Shi Q, Wei W. PMID: 33836566; PMCID: PMC7980452.
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PubMed Mentions:
23 Fields:
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HumansCells
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Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer. Sci Rep. 2020 01 15; 10(1):377.
Li R, Ong SL, Tran LM, Jing Z, Liu B, Park SJ, Huang ZL, Walser TC, Heinrich EL, Lee G, Salehi-Rad R, Crosson WP, Pagano PC, Paul MK, Xu S, Herschman H, Krysan K, Dubinett S. PMID: 31941995; PMCID: PMC6962381.
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43 Fields:
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HumansCells
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Comparison of the Efficacy and Sensitivity of Alternative PET Reporter Gene/PET Reporter Probe Systems That Minimize Biological Variables. Methods Mol Biol. 2020; 2126:177-190.
Xu S, Herschman HR. PMID: 32112389.
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PubMed Mentions:
1 Fields:
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HumansAnimalsCells
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Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression. Theranostics. 2020; 10(2):829-840.
Kim SS, Xu S, Cui J, Poddar S, Le TM, Hayrapetyan H, Li L, Wu N, Moore AM, Zhou L, Yu AC, Dann AM, Elliott IA, Abt ER, Kim W, Dawson DW, Radu CG, Donahue TR. PMID: 31903153; PMCID: PMC6929997.
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15 Fields:
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HumansAnimalsCells
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Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism. Cell Chem Biol. 2020 02 20; 27(2):197-205.e6.
Abt ER, Rosser EW, Durst MA, Lok V, Poddar S, Le TM, Cho A, Kim W, Wei L, Song J, Capri JR, Xu S, Wu N, Slavik R, Jung ME, Damoiseaux R, Czernin J, Donahue TR, Lavie A, Radu CG. PMID: 31734178; PMCID: PMC7035983.
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11 Fields:
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HumansCells
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A Tumor Agnostic Therapeutic Strategy for Hexokinase 1-Null/Hexokinase 2-Positive Cancers. Cancer Res. 2019 Dec 01; 79(23):5907-5914.
Xu S, Herschman HR. PMID: 31434645.
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PubMed Mentions:
53 Fields:
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HumansAnimalsCells
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Identification, synthesis and evaluation of CSF1R inhibitors using fragment based drug design. Comput Biol Chem. 2019 Jun; 80:374-383.
Machiraju PK, Yedla P, Gubbala SP, Bohari T, Abdul JKV, Xu S, Patel R, Chittireddy VRR, Boppana K, Jagarlapudi SARP, Neamati N, Syed R, Amanchy R. PMID: 31103918.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes. Theranostics. 2019; 9(8):2282-2298.
Xu S, Liu Y, Yang K, Wang H, Shergalis A, Kyani A, Bankhead A, Tamura S, Yang S, Wang X, Wang CC, Rehemtulla A, Ljungman M, Neamati N. PMID: 31149044; PMCID: PMC6531306.
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PubMed Mentions:
24 Fields:
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HumansAnimalsCells
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Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):6842-6847.
Elliott IA, Dann AM, Xu S, Kim SS, Abt ER, Kim W, Poddar S, Moore A, Zhou L, Williams JL, Capri JR, Ghukasyan R, Matsumura C, Tucker DA, Armstrong WR, Cabebe AE, Wu N, Li L, Le TM, Radu CG, Donahue TR. PMID: 30894490; PMCID: PMC6452719.
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PubMed Mentions:
28 Fields:
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HumansAnimalsCells
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An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1-HK2+ Multiple Myeloma. Cancer Res. 2019 05 15; 79(10):2748-2760.
Xu S, Zhou T, Doh HM, Trinh KR, Catapang A, Lee JT, Braas D, Bayley NA, Yamada RE, Vasuthasawat A, Sasine JP, Timmerman JM, Larson SM, Kim Y, MacLeod AR, Morrison SL, Herschman HR. PMID: 30885978; PMCID: PMC6522331.
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PubMed Mentions:
31 Fields:
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HumansAnimalsCells
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Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling. Cell Rep. 2018 12 04; 25(10):2919-2934.e8.
Argus JP, Wilks MQ, Zhou QD, Hsieh WY, Khialeeva E, Hoi XP, Bui V, Xu S, Yu AK, Wang ES, Herschman HR, Williams KJ, Bensinger SJ. PMID: 30517876; PMCID: PMC6432944.
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PubMed Mentions:
8 Fields:
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HumansAnimalsCells
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Hexokinase 2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin. J Nucl Med. 2018 Jun 07.
Xu S, Catapang A, Doh HM, Bayley NA, Lee JT, Braas D, Graeber TG, Herschman HR. PMID: 29880505; PMCID: PMC8833855.
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8 Fields:
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Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Nat Commun. 2016 Apr 29; 7:11457.
Krall AS, Xu S, Graeber TG, Braas D, Christofk HR. PMID: 27126896; PMCID: PMC4855534.
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PubMed Mentions:
249 Fields:
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HumansCells
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A review on PARP1 inhibitors: Pharmacophore modeling, virtual and biological screening studies to identify novel PARP1 inhibitors. Curr Top Med Chem. 2014; 14(17):2020-30.
Singh SS, Sarma JA, Narasu L, Dayam R, Xu S, Neamati N. PMID: 25262797.
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PubMed Mentions:
2 Fields:
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Humans
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Protein disulfide isomerase: a promising target for cancer therapy. Drug Discov Today. 2014 Mar; 19(3):222-40.
Xu S, Sankar S, Neamati N. PMID: 24184531.
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PubMed Mentions:
129 Fields:
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HumansAnimalsCells
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gp130: a promising drug target for cancer therapy. Expert Opin Ther Targets. 2013 Nov; 17(11):1303-28.
Xu S, Neamati N. PMID: 24099136.
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PubMed Mentions:
26 Fields:
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HumansCells
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Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma. PLoS One. 2013; 8(7):e69484.
Adisetiyo H, Liang M, Liao CP, Aycock-Williams A, Cohen MB, Xu S, Neamati N, Conway EM, Cheng CY, Nikitin AY, Roy-Burman P. PMID: 23936028; PMCID: PMC3729965.
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PubMed Mentions:
10 Fields:
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HumansAnimals
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Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues. Bioorg Med Chem Lett. 2013 Sep 15; 23(18):5135-9.
Saha S, Reddy ChV, Xu S, Sankar S, Neamati N, Patro B. PMID: 23927972.
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PubMed Mentions:
6 Fields:
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HumansCells
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Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol Cancer Ther. 2013 Jun; 12(6):937-49.
Xu S, Grande F, Garofalo A, Neamati N. PMID: 23536726.
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PubMed Mentions:
61 Fields:
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HumansAnimalsCells
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Stabilization of MDA-7/IL-24 for colon cancer therapy. Cancer Lett. 2013 Jul 28; 335(2):421-30.
Xu S, Oshima T, Imada T, Masuda M, Debnath B, Grande F, Garofalo A, Neamati N. PMID: 23481022.
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PubMed Mentions:
19 Fields:
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HumansCells
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Small molecule inhibitors of CXCR4. Theranostics. 2013; 3(1):47-75.
Debnath B, Xu S, Grande F, Garofalo A, Neamati N. PMID: 23382786; PMCID: PMC3563081.
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PubMed Mentions:
118 Fields:
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HumansAnimals
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Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties. J Med Chem. 2012 Nov 26; 55(22):9492-509.
Zeng LF, Wang Y, Kazemi R, Xu S, Xu ZL, Sanchez TW, Yang LM, Debnath B, Odde S, Xie H, Zheng YT, Ding J, Neamati N, Long YQ. PMID: 23098137.
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PubMed Mentions:
9 Fields:
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HumansCells
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Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16348-53.
Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA, Neamati N. PMID: 22988091; PMCID: PMC3479552.
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PubMed Mentions:
103 Fields:
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HumansAnimalsCells
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Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. J Med Chem. 2012 Aug 09; 55(15):6645-68.
Debnath B, Xu S, Neamati N. PMID: 22650325.
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PubMed Mentions:
81 Fields:
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HumansAnimalsCells
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Small-molecule inhibitors of p53-MDM2 interaction: the 2006-2010 update. Curr Pharm Des. 2011; 17(6):536-59.
Millard M, Pathania D, Grande F, Xu S, Neamati N. PMID: 21391905.
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PubMed Mentions:
24 Fields:
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Humans
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Biological evaluation of paclitaxel-peptide conjugates as a model for MMP2-targeted drug delivery. Cancer Biol Ther. 2010 Feb; 9(3):192-203.
Yamada R, Kostova MB, Anchoori RK, Xu S, Neamati N, Khan SR. PMID: 20023432.
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PubMed Mentions:
10 Fields:
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HumansAnimalsCells
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A chemical lipid modification of recombinant preS antigen to study the mechanism of HBV attachment to the host cell. J Biotechnol. 2008 Oct 10; 137(1-4):8-13.
Chen B, Lian M, Xu S, Luo M, Zheng X. PMID: 18675858.
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HumansCells