David A Nathanson

Title(s)Professor, Molecular and Medical Pharmacology
SchoolMedicine
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    Investigating non-apoptotic cell death in glioblastoma
    NIH R01NS143119Aug 1, 2025 - Jul 31, 2030
    Role: Principal Investigator
    Quantitative molecular MR-PET imaging of glycolysis in glioblastoma
    NIH R01CA279984Feb 10, 2023 - Feb 29, 2028
    Role: Co-Principal Investigator
    Role of decorin and diffusion MRI in anti-VEGF efficacy for recurrent glioblastoma
    NIH R01CA270027Apr 1, 2022 - Mar 31, 2027
    Role: Co-Principal Investigator
    CDKN2A couples lipid metabolism to ferroptosis in glioblastoma
    NIH R01NS121319Apr 1, 2021 - Jan 31, 2026
    Role: Principal Investigator
    Mammalian models for integrated metabolic and molecular profiling of malignant glioma
    NIH R01CA227089Jun 6, 2018 - May 31, 2023
    Role: Principal Investigator
    Targeting metabolic vulnerabilities in glioblastoma
    NIH R01CA213133Aug 7, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Engineered microenvironments as biomimetic culture platforms for studying the role of brain extracellular matrix in acquisition of resistance to EGFR inhibition across multiple biological scales
    NIH R21NS093199Sep 1, 2015 - Aug 31, 2017
    Role: Co-Principal Investigator
    Tumor Cell Biology Training Program
    NIH T32CA009056Jul 1, 1980 - Jul 31, 2028
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Translational Theranostics in Glioblastoma: FAPI-46 as a Precision Medicine Tool. J Nucl Med. 2026 Jun 04. Jeanjean P, Swaidan A, Tse C, Kwock S, Fajnorova I, Dove R, Azrour IC, Taylor S, Comin-Anduix B, Nathanson DA, Carlucci G, Calais J, Czernin J, Besserer-Offroy É, Mona CE. PMID: 42242868.
      View in: PubMed   Mentions:    Fields:    
    2. Glutamatergic neuron-tumor synapses shape human glioblastoma cell states through radial glia plasticity. bioRxiv. 2026 May 14. Martija A, Bristow BN, Rana D, Bollu S, Fazzari E, Baisiwala S, Nguyen CV, Ge W, Kan RL, Azizad DJ, Li MX, Nano PR, Cho H, Perryman T, Nathanson DA, Patel KS, Bhaduri A. PMID: 42182350; PMCID: PMC13192883.
      View in: PubMed   Mentions:
    3. Beyond cell cycle control: CDKN2A loss is associated with altered NAD+ metabolic states and increased sensitivity to NAMPT inhibition in glioblastoma. Neurooncol Adv. 2026 Jan-Dec; 8(1):vdag088. Dubey S, Yu G, Aboul-Hosn R, Tse C, Nathanson DA, Lai A, Vossel K, Rodriguez FJ. PMID: 42011292; PMCID: PMC13092126.
      View in: PubMed   Mentions:
    4. MGMT downregulation by CRISPR/Cas13 RNA-guided RNA targeting enhances glioma cell sensitivity to TMZ chemotherapy. J Neurooncol. 2026 Mar 12; 177(1). Prins TJ, Lai TJ, Li T, Fisher A, Eldred BSC, Mostafavi R, Liau LM, Chong RA, Nghiemphu PL, Cloughesy TF, Nathanson DA, Lai A. PMID: 41817895; PMCID: PMC12982228.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Predictable clonal hierarchies from restricted progenitors provide a framework for cell type-specific therapies in glioblastoma. bioRxiv. 2026 Feb 23. Fazzari E, Azizad DJ, Li MX, Ge W, Baisiwala S, Cadet D, Nano PR, Kan RL, Perryman T, Tum HA, Tse C, Wick B, Arguelles CV, Patel KS, Liau LM, Prins RM, Nathanson DA, Bhaduri A. PMID: 42124710; PMCID: PMC13160050.
      View in: PubMed   Mentions:
    6. Exemplifying Excellence in Brain Cancer Research: A Conversation with Tim Cloughesy, David A. Nathanson, and Johannes Czernin. J Nucl Med. 2026 Feb 02; 67(2):163-165. Cloughesy T, Nathanson DA, Czernin J. PMID: 41545067.
      View in: PubMed   Mentions:    Fields:    
    7. Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1. Cell Rep. 2026 Jan 27; 45(1):116848. Ge W, Kan RL, Yilgor C, Fazzari E, Nano PR, Azizad DJ, Shinglot H, Li M, Ito JY, Tse C, Tum HA, Scholes J, Baisiwala S, Patel KS, Nathanson DA, Bhaduri A. PMID: 41543935; PMCID: PMC12950190.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. A human tumor-immune organoid model of glioblastoma. Cell Rep. 2026 Jan 27; 45(1):116790. Baisiwala S, Fazzari E, Li MX, Martija A, Azizad DJ, Sun L, Herrera G, Phan T, Monteleone A, Kan RL, Nathanson DA, Wang AC, Kim W, Everson RG, Patel KS, Liau LM, Prins RM, Bhaduri A. PMID: 41505256; PMCID: PMC12969483.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    9. Beyond Cell Cycle Control: CDKN2A Loss Orchestrates NAD + Metabolic Plasticity and NAMPT Inhibitor Sensitivity in Glioblastoma. bioRxiv. 2025 Dec 04. Dubey S, Yu G, Aboul-Hosn R, Tse C, Nathanson DA, Lai A, Vossel K, Rodriguez FJ. PMID: 41573886; PMCID: PMC12822722.
      View in: PubMed   Mentions: 1  
    10. Impact of corticosteroid administration on contrast-enhancing volume and diffusion MRI in treatment naïve glioblastoma. Neuro Oncol. 2025 Nov 01; 27(11):3016-3026. Sanvito F, Kim A, Raymond C, Teraishi A, Everson RG, Nghiemphu PL, Lai A, Chong RA, Nathanson DA, Salamon N, Cloughesy TF, Yao J, Ellingson BM. PMID: 40443040; PMCID: PMC12908483.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma. Neuro Oncol. 2025 Nov 01; 27(11):2828-2842. Vadla R, Taylor B, Miyake Y, Lin B, Kawauchi D, Miki S, Nathwani N, Jones BM, Kaur Y, Banerjee A, Pham P, Tsang J, Baldwin A, Nathanson DA, Pizzo DP, Miller CR, Furnari FB. PMID: 40686478; PMCID: PMC12700489.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Allogeneic stem cell-engineered EGFRvIII-specific CAR-NKT cells for treating glioblastoma with enhanced efficacy and safety. Mol Ther. 2025 Dec 03; 33(12):6041-6062. Li YR, Zhu Y, Li Z, Shen X, Halladay T, Tse C, Tian Y, Huang J, Zhao AS, Ma NY, Zhang C, Nathanson DA, Prins RM, Yang L. PMID: 40946163; PMCID: PMC12703166.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma. Acta Neuropathol Commun. 2025 06 28; 13(1):143. Lin B, Shelton AK, Smithberger E, Ziebro J, Skinner KR, Bash RE, Kirkman R, Stamper A, Butler M, Flores A, Angus SP, East MP, Cloughesy TF, Nathanson DA, Berens ME, Sarkaria JN, Binder ZA, O'Rourke DM, Howton TC, Lasseigne BN, Willey CD, Johnson GL, Hjelmeland AB, Furnari FB, Miller CR. PMID: 40581663; PMCID: PMC12205505.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. A Human Tumor-Immune Organoid Model of Glioblastoma. bioRxiv. 2025 Jun 20. Baisiwala S, Fazzari E, Li MX, Martija A, Azizad DJ, Sun L, Herrera G, Phan T, Monteleone A, Nathanson DA, Wang A, Kim W, Everson RG, Patel KS, Liau LM, Prins RM, Bhaduri A. PMID: 40667050; PMCID: PMC12262450.
      View in: PubMed   Mentions: 1  
    15. Tegavivint triggers TECR-dependent nonapoptotic cancer cell death. Nat Chem Biol. 2025 Dec; 21(12):1873-1884. Leak L, Wang Z, Joseph AJ, Johnson B, Chan AA, Decosto CM, Magtanong L, Ko PJ, Lee WC, Ritho J, Manukian S, Millner A, Chitkara S, Salinas JJ, Skouta R, Rees MG, Ronan MM, Roth JA, Myers CL, Moffat J, Boone C, Bensinger SJ, Nathanson DA, Atilla-Gokcumen GE, Moding EJ, Dixon SJ. PMID: 40419770; PMCID: PMC13119621.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. Severe hypoglycaemia is associated with increased risk of adverse cardiovascular complications in adults with type 1 diabetes: risk mitigation using intermittently scanned continuous glucose monitoring. Diabetologia. 2025 Aug; 68(8):1647-1656. Eeg-Olofsson K, Nathanson D, Spelman T, Kyhlstedt M, Seibold A, Levrat-Guillen F, Bolinder J. PMID: 40272529; PMCID: PMC12245946.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Advanced imaging characterization of post-chemoradiation glioblastoma stratified by diffusion MRI phenotypes known to predict favorable anti-VEGF response. J Neurooncol. 2025 Jul; 173(3):583-594. Sanvito F, Kryukov I, Yao J, Teraishi A, Raymond C, Gao J, Miller C, Nghiemphu PL, Lai A, Liau LM, Patel K, Everson RG, Eldred BSC, Prins RM, Nathanson DA, Salamon N, Cloughesy TF, Ellingson BM. PMID: 40227555; PMCID: PMC12170782.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. A comparative study of preclinical and clinical molecular imaging response to EGFR inhibition using osimertinib in glioblastoma. Neurooncol Adv. 2025 Jan-Dec; 7(1):vdaf022. Ellingson BM, Okobi Q, Chong R, Plawat R, Zhao E, Gafita A, Sonni I, Chun S, Filka E, Yao J, Telesca D, Li S, Li G, Lai A, Nghiemphu P, Czernin J, Nathanson DA, Cloughesy TF. PMID: 40051661; PMCID: PMC11883343.
      View in: PubMed   Mentions: 2  
    19. A clinical drug candidate that triggers non-apoptotic cancer cell death. Res Sq. 2025 Feb 11. Dixon S, Leak L, Wang Z, Lee WC, Johnson B, Millner A, Ko PJ, Decosto C, Magtanong L, Ritho J, Skouta R, Atilla-Gokcumen E, Myers C, Moffat J, Boone C, Bensinger S, Moding E, Joseph A, Chan A, Chitkara S, Salinas J, Nathanson D. PMID: 39989975; PMCID: PMC11844650.
      View in: PubMed   Mentions:
    20. Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Associated With Reduced Hospitalization for Acute Diabetes Events and Cardiovascular Complications in Adults With Type 1 Diabetes. Diabetes Care. 2024 12 01; 47(12):2164-2171. Eeg-Olofsson K, Nathanson D, Spelman T, Kyhlstedt M, Bülow E, Levrat-Guillen F, Bolinder J. PMID: 39316385.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma. Nat Commun. 2024 11 21; 15(1):10089. Fernandez EG, Mai WX, Song K, Bayley NA, Kim J, Zhu H, Pioso M, Young P, Andrasz CL, Cadet D, Liau LM, Li G, Yong WH, Rodriguez FJ, Dixon SJ, Souers AJ, Li JJ, Graeber TG, Cloughesy TF, Nathanson DA. PMID: 39572533; PMCID: PMC11582606.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Intermittently scanned continuous glucose monitoring compared with blood glucose monitoring is associated with lower HbA1c and a reduced risk of hospitalisation for diabetes-related complications in adults with type 2 diabetes on insulin therapies. Diabetologia. 2025 01; 68(1):41-51. Nathanson D, Eeg-Olofsson K, Spelman T, Bülow E, Kyhlstedt M, Levrat-Guillen F, Bolinder J. PMID: 39460755; PMCID: PMC11663194.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    23. IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β-mediated immune suppression and potentiate anti-tumor responses in glioblastoma. Neuro Oncol. 2024 Oct 03; 26(10):1850-1866. Hou AJ, Shih RM, Uy BR, Shafer A, Chang ZL, Comin-Anduix B, Guemes M, Galic Z, Phyu S, Okada H, Grausam KB, Breunig JJ, Brown CE, Nathanson DA, Prins RM, Chen YY. PMID: 38982561; PMCID: PMC11449012.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    24. Glioblastoma Neurovascular Progenitor Orchestrates Tumor Cell Type Diversity. bioRxiv. 2024 Jul 24. Fazzari E, Azizad DJ, Yu K, Ge W, Li MX, Nano PR, Kan RL, Tum HA, Tse C, Bayley NA, Haka V, Cadet D, Perryman T, Soto JA, Wick B, Raleigh DR, Crouch EE, Patel KS, Liau LM, Deneen B, Nathanson DA, Bhaduri A. PMID: 39091877; PMCID: PMC11291138.
      View in: PubMed   Mentions:
    25. Epigenetic Induction of Cancer-Testis Antigens and Endogenous Retroviruses at Single-Cell Level Enhances Immune Recognition and Response in Glioma. Cancer Res Commun. 2024 07 01; 4(7):1834-1849. Lai TJ, Sun L, Li K, Prins TJ, Treger J, Li T, Sun MZ, Nathanson DA, Liau LM, Lai A, Prins RM, Everson RG. PMID: 38856710; PMCID: PMC11275559.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    26. D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation. Cancer Res Commun. 2024 03 22; 4(3):876-894. Pianka ST, Li T, Prins TJ, Eldred BSC, Kevan BM, Liang H, Zapanta Rinonos S, Kornblum HI, Nathanson DA, Pellegrini M, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. PMID: 38445960; PMCID: PMC10959073.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    27. Standardising personalised diabetes care across European health settings: A person-centred outcome set agreed in a multinational Delphi study. Diabet Med. 2024 May; 41(5):e15259. Porth AK, Huberts AS, Rogge A, Bénard AHM, Forbes A, Strootker A, Del Pozo CH, Kownatka D, Hopkins D, Nathanson D, Aanstoot HJ, Soderberg J, Eeg-Olofsson K, Hamilton K, Delbecque L, Ninov L, Due-Christensen M, Leutner M, Simó R, Vikstrom-Greve S, Rössner S, Flores V, Seidler Y, Hasler Y, Stamm T, Kautzky-Willer A. PMID: 38017616.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    28. 18F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma. Chem Sci. 2023 Dec 06; 14(47):13825-13831. Narayanam MK, Tsang JE, Xu S, Nathanson DA, Murphy JM. PMID: 38075671; PMCID: PMC10699577.
      View in: PubMed   Mentions: 3  
    29. M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance. Neuro Oncol. 2023 11 02; 25(11):1989-2000. Bailleul J, Ruan Y, Abdulrahman L, Scott AJ, Yazal T, Sung D, Park K, Hoang H, Nathaniel J, Chu FI, Palomera D, Sehgal A, Tsang JE, Nathanson DA, Xu S, Park JO, Ten Hoeve J, Bhat K, Qi N, Kornblum HI, Schaue D, McBride WH, Lyssiotis CA, Wahl DR, Vlashi E. PMID: 37279645; PMCID: PMC10628945.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    30. Depth of Radiographic Response and Time to Tumor Regrowth Predicts Overall Survival Following Anti-VEGF Therapy in Recurrent Glioblastoma. Clin Cancer Res. 2023 10 13; 29(20):4186-4195. Ellingson BM, Hagiwara A, Morris CJ, Cho NS, Oshima S, Sanvito F, Oughourlian TC, Telesca D, Raymond C, Abrey LE, Garcia J, Aftab DT, Hessel C, Rachmilewitz Minei T, Harats D, Nathanson DA, Wen PY, Cloughesy TF. PMID: 37540556; PMCID: PMC10592195.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    31. Differential Susceptibility of Ex Vivo Primary Glioblastoma Tumors to Oncolytic Effect of Modified Zika Virus. Cells. 2023 09 29; 12(19). Garcia G, Chakravarty N, Paiola S, Urena E, Gyani P, Tse C, French SW, Danielpour M, Breunig JJ, Nathanson DA, Arumugaswami V. PMID: 37830597; PMCID: PMC10572118.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    32. Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors. J Clin Invest. 2023 09 01; 133(17). Sun L, Kienzler JC, Reynoso JG, Lee A, Shiuan E, Li S, Kim J, Ding L, Monteleone AJ, Owens GC, Phillips JJ, Everson RG, Nathanson D, Cloughesy TF, Li G, Liau LM, Hugo W, Kim W, Prins RM. PMID: 37655659; PMCID: PMC10471177.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    33. Which diabetes specific patient reported outcomes should be measured in routine care? A systematic review to inform a core outcome set for adults with Type 1 and 2 diabetes mellitus: The European Health Outcomes Observatory (H2O) programme. Patient Educ Couns. 2023 11; 116:107933. Hamilton K, Forde R, Due-Christensen M, Eeg-Olofson K, Nathanson D, Rossner S, Vikstrom-Greve S, Porth AK, Seidler Y, Kautzky-Willer A, Delbecque L, Ozdemir Saltik AZ, Hasler Y, Flores V, Stamm T, Hopkins D, Forbes A. PMID: 37672919.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    34. Calculation of ATP production rates using the Seahorse XF Analyzer. EMBO Rep. 2023 10 09; 24(10):e56380. Desousa BR, Kim KK, Jones AE, Ball AB, Hsieh WY, Swain P, Morrow DH, Brownstein AJ, Ferrick DA, Shirihai OS, Neilson A, Nathanson DA, Rogers GW, Dranka BP, Murphy AN, Affourtit C, Bensinger SJ, Stiles L, Romero N, Divakaruni AS. PMID: 37548091; PMCID: PMC10561364.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    35. Glioblastoma Mesenchymal Transition and Invasion are Dependent on a NF-κB/BRD2 Chromatin Complex. bioRxiv. 2023 Jul 03. Vadla R, Miki S, Taylor B, Kawauchi D, Jones BM, Nathwani N, Pham P, Tsang J, Nathanson DA, Furnari FB. PMID: 37461511; PMCID: PMC10349949.
      View in: PubMed   Mentions:
    36. Multi-nuclear sodium, diffusion, and perfusion MRI in human gliomas. J Neurooncol. 2023 Jun; 163(2):417-427. Cho NS, Sanvito F, Thakuria S, Wang C, Hagiwara A, Nagaraj R, Oshima S, Lopez Kolkovsky AL, Lu J, Raymond C, Liau LM, Everson RG, Patel KS, Kim W, Yang I, Bergsneider M, Nghiemphu PL, Lai A, Nathanson DA, Cloughesy TF, Ellingson BM. PMID: 37294422; PMCID: PMC10322966.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    37. CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis. Cancer Cell. 2023 06 12; 41(6):1048-1060.e9. Minami JK, Morrow D, Bayley NA, Fernandez EG, Salinas JJ, Tse C, Zhu H, Su B, Plawat R, Jones A, Sammarco A, Liau LM, Graeber TG, Williams KJ, Cloughesy TF, Dixon SJ, Bensinger SJ, Nathanson DA. PMID: 37236196; PMCID: PMC10330677.
      View in: PubMed   Mentions: 106     Fields:    Translation:Humans
    38. History of heart failure and chronic kidney disease and risk of all-cause death after COVID-19 during the first three waves of the pandemic in comparison with influenza outbreaks in Sweden: a registry-based, retrospective, case-control study. BMJ Open. 2023 04 28; 13(4):e069037. Ritsinger V, Bodegård J, Kristofi R, Thuresson M, Nathanson D, Nyström T, Eriksson J, Norhammar A. PMID: 37117003; PMCID: PMC10151240.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    39. Corrigendum to: EGFR, the Lazarus target for precision oncology in glioblastoma. Neuro Oncol. 2023 Jan 05; 25(1):213. Lin B, Ziebro J, Smithberger E, Skinner KR, Zhao E, Cloughesy TF, Binder ZA, O'Rourke DM, Nathanson DA, Furnari FB, Miller CR. PMID: 36416495; PMCID: PMC9825333.
      View in: PubMed   Mentions: 2     Fields:    
    40. Patients with type 1 and type 2 diabetes hospitalized with COVID-19 in comparison with influenza: mortality and cardiorenal complications assessed by nationwide Swedish registry data. Cardiovasc Diabetol. 2022 12 15; 21(1):282. Kristófi R, Bodegard J, Ritsinger V, Thuresson M, Nathanson D, Nyström T, Norhammar A, Eriksson JW. PMID: 36522650; PMCID: PMC9753889.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Cardiovascular Outcomes in Patients With Both Diabetes and Phenotypic Familial Hypercholesterolemia: A Nationwide Register-Based Cohort Study. Diabetes Care. 2022 12 01; 45(12):3040-3049. Brinck J, Hagström E, Nåtman J, Franzén S, Eeg-Olofsson K, Nathanson D, Eliasson B. PMID: 36326759; PMCID: PMC9862487.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    42. EGFR, the Lazarus target for precision oncology in glioblastoma. Neuro Oncol. 2022 12 01; 24(12):2035-2062. Lin B, Ziebro J, Smithberger E, Skinner KR, Zhao E, Cloughesy TF, Binder ZA, O'Rourke DM, Nathanson DA, Furnari FB, Miller CR. PMID: 36125064; PMCID: PMC9713527.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    43. Hypoglycemia after exposure of diclofenac medication. Endocrine. 2023 03; 79(3):455-458. Falhammar H, Törring O, Larsson M, Nathanson D. PMID: 36374446.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein. Cell Chem Biol. 2022 11 17; 29(11):1588-1600.e7. Armenta DA, Laqtom NN, Alchemy G, Dong W, Morrow D, Poltorack CD, Nathanson DA, Abu-Remalieh M, Dixon SJ. PMID: 36306785; PMCID: PMC9762237.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    45. Pathway-based approach reveals differential sensitivity to E2F1 inhibition in glioblastoma. Cancer Res Commun. 2022 09; 2(9):1049-1060. Alvarado AG, Tessema K, Muthukrishnan SD, Sober M, Kawaguchi R, Laks DR, Bhaduri A, Swarup V, Nathanson DA, Geschwind DH, Goldman SA, Kornblum HI. PMID: 36213002; PMCID: PMC9536135.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    46. Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis. Immunology. 2023 01; 168(1):152-169. Chen BY, Salas JR, Trias AO, Perez Rodriguez A, Tsang JE, Guemes M, Le TM, Galic Z, Shepard HM, Steinman L, Nathanson DA, Czernin J, Witte ON, Radu CG, Schultz KA, Clark PM. PMID: 35986643; PMCID: PMC9844239.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    47. Amine-weighted chemical exchange saturation transfer magnetic resonance imaging in brain tumors. NMR Biomed. 2023 06; 36(6):e4785. Cho NS, Hagiwara A, Yao J, Nathanson DA, Prins RM, Wang C, Raymond C, Desousa BR, Divakaruni A, Morrow DH, Nghiemphu PL, Lai A, Liau LM, Everson RG, Salamon N, Pope WB, Cloughesy TF, Ellingson BM. PMID: 35704275; PMCID: PMC13030910.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    48. Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres. Commun Biol. 2022 05 10; 5(1):436. Breznik B, Ko MW, Tse C, Chen PC, Senjor E, Majc B, Habic A, Angelillis N, Novak M, Župunski V, Mlakar J, Nathanson D, Jewett A. PMID: 35538218; PMCID: PMC9090761.
      View in: PubMed   Mentions: 28  Translation:HumansCells
    49. The transcription factor Fli1 restricts the formation of memory precursor NK cells during viral infection. Nat Immunol. 2022 04; 23(4):556-567. Riggan L, Ma F, Li JH, Fernandez E, Nathanson DA, Pellegrini M, O'Sullivan TE. PMID: 35288713; PMCID: PMC8989647.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    50. Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma. Nat Commun. 2021 11 26; 12(1):6938. Lee AH, Sun L, Mochizuki AY, Reynoso JG, Orpilla J, Chow F, Kienzler JC, Everson RG, Nathanson DA, Bensinger SJ, Liau LM, Cloughesy T, Hugo W, Prins RM. PMID: 34836966; PMCID: PMC8626557.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
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    52. Dopamine Receptor Antagonists, Radiation, and Cholesterol Biosynthesis in Mouse Models of Glioblastoma. J Natl Cancer Inst. 2021 08 02; 113(8):1094-1104. Bhat K, Saki M, Cheng F, He L, Zhang L, Ioannidis A, Nathanson D, Tsang J, Bensinger SJ, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 33556960; PMCID: PMC8328983.
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    56. Metabolic Vulnerabilities in Brain Cancer. Neurosurg Clin N Am. 2021 Apr; 32(2):159-169. Morrow D, Minami J, Nathanson DA. PMID: 33781499.
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    58. Cardiovascular and Renal Disease Burden in Type 1 Compared With Type 2 Diabetes: A Two-Country Nationwide Observational Study. Diabetes Care. 2021 05; 44(5):1211-1218. Kristófi R, Bodegard J, Norhammar A, Thuresson M, Nathanson D, Nyström T, Birkeland KI, Eriksson JW. PMID: 33653822; PMCID: PMC8132335.
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    59. Correction to: Sex-specific risks of death in patients hospitalized for hyponatremia: a population-based study. Endocrine. 2021 Feb; 71(2):531. Mannheimer B, Skov J, Falhammar H, Calissendorff J, Lindh JD, Nathanson D. PMID: 33231811; PMCID: PMC8025274.
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    63. Relative oxygen extraction fraction (rOEF) MR imaging reveals higher hypoxia in human epidermal growth factor receptor (EGFR) amplified compared with non-amplified gliomas. Neuroradiology. 2021 Jun; 63(6):857-868. Oughourlian TC, Yao J, Yao J, Hagiwara A, Nathanson DA, Raymond C, Pope WB, Salamon N, Lai A, Ji M, Nghiemphu PL, Liau LM, Cloughesy TF, Ellingson BM. PMID: 33106922; PMCID: PMC8071834.
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    64. Associations Between Antihypertensive Medications and Severe Hyponatremia: A Swedish Population-Based Case-Control Study. J Clin Endocrinol Metab. 2020 10 01; 105(10). Falhammar H, Skov J, Calissendorff J, Nathanson D, Lindh JD, Mannheimer B. PMID: 32285124; PMCID: PMC7451505.
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    67. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Med Chem Lett. 2020 Oct 08; 11(10):1799-1809. Tsang JE, Urner LM, Kim G, Chow K, Baufeld L, Faull K, Cloughesy TF, Clark PM, Jung ME, Nathanson DA. PMID: 33062157; PMCID: PMC7549123.
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    79. Atypical Chemokine Receptor 1 (DARC/ACKR1) in Breast Tumors Is Associated with Survival, Circulating Chemokines, Tumor-Infiltrating Immune Cells, and African Ancestry. Cancer Epidemiol Biomarkers Prev. 2019 04; 28(4):690-700. Jenkins BD, Martini RN, Hire R, Brown A, Bennett B, Brown I, Howerth EW, Egan M, Hodgson J, Yates C, Kittles R, Chitale D, Ali H, Nathanson D, Nikolinakos P, Newman L, Monteil M, Davis MB. PMID: 30944146; PMCID: PMC6450416.
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    90. Surface Immobilization of Redox-Labile Fluorescent Probes: Enabling Single-Cell Co-Profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities. Angew Chem Int Ed Engl. 2018 09 03; 57(36):11554-11558. Li Z, Cheng H, Shao S, Lu X, Mo L, Tsang J, Zeng P, Guo Z, Wang S, Nathanson DA, Heath JR, Wei W, Xue M. PMID: 29992724; PMCID: PMC6443403.
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    93. Type 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin. Acta Neuropathol Commun. 2018 02 23; 6(1):14. Lietzau G, Davidsson W, Östenson CG, Chiazza F, Nathanson D, Pintana H, Skogsberg J, Klein T, Nyström T, Darsalia V, Patrone C. PMID: 29471869; PMCID: PMC5824492.
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    109. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 2015 Sep 01; 22(3):508-15. Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J. PMID: 26190651; PMCID: PMC4663076.
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    110. Quantitative assessments of glycolysis from single cells. Technology (Singap World Sci). 2015 Jun; 3(4):172-178. Shin YS, Kim J, Johnson D, Dooraghi AA, Mai WX, Ta L, Chatziioannou AF, Phelps ME, Nathanson DA, Heath JR. PMID: 26835505; PMCID: PMC4728151.
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    111. Chemical methods for the simultaneous quantitation of metabolites and proteins from single cells. J Am Chem Soc. 2015 Apr 01; 137(12):4066-9. Xue M, Wei W, Su Y, Kim J, Shin YS, Mai WX, Nathanson DA, Heath JR. PMID: 25789560; PMCID: PMC4883658.
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    112. Glucagon-like receptor 1 agonists and DPP-4 inhibitors: potential therapies for the treatment of stroke. J Cereb Blood Flow Metab. 2015 May; 35(5):718-23. Darsalia V, Larsson M, Nathanson D, Klein T, Nyström T, Patrone C. PMID: 25669907; PMCID: PMC4420864.
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    113. Sex, diastolic blood pressure, and outcome after thrombolysis for ischemic stroke. Stroke Res Treat. 2014; 2014:747458. Nathanson D, Patrone C, Nyström T, von Euler M. PMID: 25302134; PMCID: PMC4181774.
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    114. Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization. PLoS One. 2014; 9(8):e103114. Darsalia V, Hua S, Larsson M, Mallard C, Nathanson D, Nyström T, Sjöholm Å, Johansson ME, Patrone C. PMID: 25101679; PMCID: PMC4125154.
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    115. Fully automated production of diverse 18F-labeled PET tracers on the ELIXYS multireactor radiosynthesizer without hardware modification. J Nucl Med Technol. 2014 Sep; 42(3):203-10. Lazari M, Collins J, Shen B, Farhoud M, Yeh D, Maraglia B, Chin FT, Nathanson DA, Moore M, van Dam RM. PMID: 25033883; PMCID: PMC4491436.
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    116. Linagliptin enhances neural stem cell proliferation after stroke in type 2 diabetic mice. Regul Pept. 2014 May; 190-191:25-31. Darsalia V, Olverling A, Larsson M, Mansouri S, Nathanson D, Nyström T, Klein T, Sjöholm Å, Patrone C. PMID: 24821550.
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    117. The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia. Dis Model Mech. 2014 Jul; 7(7):895-905. Danilova N, Bibikova E, Covey TM, Nathanson D, Dimitrova E, Konto Y, Lindgren A, Glader B, Radu CG, Sakamoto KM, Lin S. PMID: 24812435; PMCID: PMC4073278.
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    118. Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J Exp Med. 2014 Mar 10; 211(3):473-86. Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. PMID: 24567448; PMCID: PMC3949575.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCellsPHPublic Health
    119. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science. 2014 Jan 03; 343(6166):72-6. Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, Mischel PS. PMID: 24310612; PMCID: PMC4049335.
      View in: PubMed   Mentions: 399     Fields:    Translation:HumansAnimalsCells
    120. The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clin Cancer Res. 2013 Oct 15; 19(20):5722-32. Gini B, Zanca C, Guo D, Matsutani T, Masui K, Ikegami S, Yang H, Nathanson D, Villa GR, Shackelford D, Zhu S, Tanaka K, Babic I, Akhavan D, Lin K, Assuncao A, Gu Y, Bonetti B, Mortensen DS, Xu S, Raymon HK, Cavenee WK, Furnari FB, James CD, Kroemer G, Heath JR, Hege K, Chopra R, Cloughesy TF, Mischel PS. PMID: 24030701; PMCID: PMC3815450.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    121. Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system. J Nucl Med. 2013 Oct; 54(10):1820-4. Wang J, Hwang K, Braas D, Dooraghi A, Nathanson D, Campbell DO, Gu Y, Sandberg T, Mischel P, Radu C, Chatziioannou AF, Phelps ME, Christofk H, Heath JR. PMID: 23978446; PMCID: PMC4106462.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    122. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem. 2013 Sep 12; 56(17):6696-708. Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. PMID: 23947754; PMCID: PMC3789385.
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    123. EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell Metab. 2013 Jun 04; 17(6):1000-1008. Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee WK, Cloughesy TF, Christofk HR, Black DL, Mischel PS. PMID: 23707073; PMCID: PMC3679227.
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    124. PET/CT in Oncology: Current Status and Perspectives. Curr Radiol Rep. 2013; 1:177-190. Czernin J, Allen-Auerbach M, Nathanson D, Herrmann K. PMID: 24883234; PMCID: PMC4034170.
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    125. Evaluation of the Genisys4, a bench-top preclinical PET scanner. J Nucl Med. 2013 Jul; 54(7):1162-7. Herrmann K, Dahlbom M, Nathanson D, Wei L, Radu C, Chatziioannou A, Czernin J. PMID: 23628700; PMCID: PMC3790646.
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    126. De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discov. 2013 May; 3(5):534-47. Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS. PMID: 23533263; PMCID: PMC3651754.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    127. Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Cancer Discov. 2012 Dec; 2(12):1109-17. Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR. PMID: 23230188; PMCID: PMC3531869.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    128. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med. 2012 Nov 19; 209(12):2215-28. Austin WR, Armijo AL, Campbell DO, Singh AS, Hsieh T, Nathanson D, Herschman HR, Phelps ME, Witte ON, Czernin J, Radu CG. PMID: 23148236; PMCID: PMC3501349.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    129. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14164-9. Fenton TR, Nathanson D, Ponte de Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo SM, Uno M, Inda MM, Wykosky J, Bachoo RM, James CD, DePinho RA, Vandenberg SR, Zhou H, Marie SK, Mischel PS, Cavenee WK, Furnari FB. PMID: 22891331; PMCID: PMC3435194.
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    130. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discov. 2011 Oct; 1(5):442-56. Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, Kuga D, Amzajerdi AN, Soto H, Zhu S, Babic I, Tanaka K, Dang J, Iwanami A, Gini B, Dejesus J, Lisiero DD, Huang TT, Prins RM, Wen PY, Robins HI, Prados MD, Deangelis LM, Mellinghoff IK, Mehta MP, James CD, Chakravarti A, Cloughesy TF, Tontonoz P, Mischel PS. PMID: 22059152; PMCID: PMC3207317.
      View in: PubMed   Mentions: 269     Fields:    Translation:HumansAnimalsCells
    131. Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance. Cancer Discov. 2011 Nov; 1(6):524-38. Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, De Jesus J, Amzajerdi AN, Zhang Y, Dibble CC, Dan H, Rinkenbaugh A, Yong WH, Vinters HV, Gera JF, Cavenee WK, Cloughesy TF, Manning BD, Baldwin AS, Mischel PS. PMID: 22145100; PMCID: PMC3229221.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansCells
    132. Charting the course across the blood-brain barrier. J Clin Invest. 2011 Jan; 121(1):31-3. Nathanson D, Mischel PS. PMID: 21183784; PMCID: PMC3007172.
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    133. A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer Res. 2010 Aug 01; 70(15):6128-38. Sun J, Masterman-Smith MD, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, DeJesus J, Kamei K, Lee KB, Wang H, Yu ZT, Lu YT, Hou S, Li K, Liu M, Zhang N, Wang S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathanson D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI, Yong WH, Graeber TG, Tseng HR. PMID: 20631065; PMCID: PMC3163840.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    134. An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. Curr Biol. 2009 Nov 17; 19(21):1788-98. Tarcic G, Boguslavsky SK, Wakim J, Kiuchi T, Liu A, Reinitz F, Nathanson D, Takahashi T, Mischel PS, Ng T, Yarden Y. PMID: 19836242; PMCID: PMC2783429.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    135. Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples. Clin Cancer Res. 2008 Jan 15; 14(2):488-93. Yoshimoto K, Dang J, Zhu S, Nathanson D, Huang T, Dumont R, Seligson DB, Yong WH, Xiong Z, Rao N, Winther H, Chakravarti A, Bigner DD, Mellinghoff IK, Horvath S, Cavenee WK, Cloughesy TF, Mischel PS. PMID: 18223223.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    136. Routine surveillance care after cancer treatment with curative intent. Med Care. 2005 Jun; 43(6):592-9. Elston Lafata J, Simpkins J, Schultz L, Chase GA, Johnson CC, Yood MU, Lamerato L, Nathanson D, Cooper G. PMID: 15908854.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    137. Timeline of tibial tunnel expansion after single-incision hamstring anterior cruciate ligament reconstruction. Arthroscopy. 2004 Jan; 20(1):34-6. Buck DC, Simonian PT, Larson RV, Borrow J, Nathanson DA. PMID: 14716276.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCTClinical Trials
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