David A Nathanson

Title(s)Associate Professor, Molecular and Medical Pharmacology
SchoolMedicine
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    Collapse Research 
    Collapse Research Activities and Funding
    CDKN2A couples lipid metabolism to ferroptosis in glioblastoma
    NIH R01NS121319Apr 1, 2021 - Jan 31, 2026
    Role: Principal Investigator
    Mammalian models for integrated metabolic and molecular profiling of malignant glioma
    NIH R01CA227089Jun 6, 2018 - May 31, 2023
    Role: Principal Investigator
    Targeting metabolic vulnerabilities in glioblastoma
    NIH R01CA213133Aug 7, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Engineered microenvironments as biomimetic culture platforms for studying the role of brain extracellular matrix in acquisition of resistance to EGFR inhibition across multiple biological scales
    NIH R21NS093199Sep 1, 2015 - Aug 31, 2017
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. EGFR, the Lazarus target for precision oncology in glioblastoma. Neuro Oncol. 2022 Dec 01; 24(12):2035-2062. Lin B, Ziebro J, Smithberger E, Skinner KR, Zhao E, Cloughesy TF, Binder ZA, O'Rourke DM, Nathanson DA, Furnari FB, Miller CR. PMID: 36125064; PMCID: PMC9713527.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    2. Corrigendum to: EGFR, the Lazarus target for precision oncology in glioblastoma. Neuro Oncol. 2022 Nov 23. Lin B, Ziebro J, Smithberger E, Skinner KR, Zhao E, Cloughesy TF, Binder ZA, O'Rourke DM, Nathanson DA, Furnari FB, Miller CR. PMID: 36416495.
      View in: PubMed   Mentions:    Fields:    
    3. Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein. Cell Chem Biol. 2022 Nov 17; 29(11):1588-1600.e7. Armenta DA, Laqtom NN, Alchemy G, Dong W, Morrow D, Poltorack CD, Nathanson DA, Abu-Remalieh M, Dixon SJ. PMID: 36306785.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    4. Pathway-based approach reveals differential sensitivity to E2F1 inhibition in glioblastoma. Cancer Res Commun. 2022 Sep; 2(9):1049-1060. Alvarado AG, Tessema K, Muthukrishnan SD, Sober M, Kawaguchi R, Laks DR, Bhaduri A, Swarup V, Nathanson DA, Geschwind DH, Goldman SA, Kornblum HI. PMID: 36213002; PMCID: PMC9536135.
      View in: PubMed   Mentions:
    5. Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis. Immunology. 2023 01; 168(1):152-169. Chen BY, Salas JR, Trias AO, Perez Rodriguez A, Tsang JE, Guemes M, Le TM, Galic Z, Shepard HM, Steinman L, Nathanson DA, Czernin J, Witte ON, Radu CG, Schultz KA, Clark PM. PMID: 35986643; PMCID: PMC9844239.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Amine-weighted chemical exchange saturation transfer magnetic resonance imaging in brain tumors. NMR Biomed. 2022 Jun 15; e4785. Cho NS, Hagiwara A, Yao J, Nathanson DA, Prins RM, Wang C, Raymond C, Desousa BR, Divakaruni A, Morrow DH, Nghiemphu PL, Lai A, Liau LM, Everson RG, Salamon N, Pope WB, Cloughesy TF, Ellingson BM. PMID: 35704275.
      View in: PubMed   Mentions: 3     Fields:    
    7. Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres. Commun Biol. 2022 05 10; 5(1):436. Breznik B, Ko MW, Tse C, Chen PC, Senjor E, Majc B, Habic A, Angelillis N, Novak M, Župunski V, Mlakar J, Nathanson D, Jewett A. PMID: 35538218; PMCID: PMC9090761.
      View in: PubMed   Mentions: 1  Translation:HumansCells
    8. The transcription factor Fli1 restricts the formation of memory precursor NK cells during viral infection. Nat Immunol. 2022 04; 23(4):556-567. Riggan L, Ma F, Li JH, Fernandez E, Nathanson DA, Pellegrini M, O'Sullivan TE. PMID: 35288713; PMCID: PMC8989647.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma. Nat Commun. 2021 11 26; 12(1):6938. Lee AH, Sun L, Mochizuki AY, Reynoso JG, Orpilla J, Chow F, Kienzler JC, Everson RG, Nathanson DA, Bensinger SJ, Liau LM, Cloughesy T, Hugo W, Prins RM. PMID: 34836966; PMCID: PMC8626557.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    10. "Aerobic glycolytic imaging" of human gliomas using combined pH-, oxygen-, and perfusion-weighted magnetic resonance imaging. Neuroimage Clin. 2021; 32:102882. Hagiwara A, Yao J, Raymond C, Cho NS, Everson R, Patel K, Morrow DH, Desousa BR, Mareninov S, Chun S, Nathanson DA, Yong WH, Andrei G, Divakaruni AS, Salamon N, Pope WB, Nghiemphu PL, Liau LM, Cloughesy TF, Ellingson BM. PMID: 34911188; PMCID: PMC8609049.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Dopamine Receptor Antagonists, Radiation, and Cholesterol Biosynthesis in Mouse Models of Glioblastoma. J Natl Cancer Inst. 2021 08 02; 113(8):1094-1104. Bhat K, Saki M, Cheng F, He L, Zhang L, Ioannidis A, Nathanson D, Tsang J, Bensinger SJ, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 33556960; PMCID: PMC8328983.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    12. Metabolic Vulnerabilities in Brain Cancer. Neurosurg Clin N Am. 2021 Apr; 32(2):159-169. Morrow D, Minami J, Nathanson DA. PMID: 33781499.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. A physical phantom for amine chemical exchange saturation transfer (CEST) MRI. MAGMA. 2021 Aug; 34(4):569-580. Yao J, Yao J, Wang C, Raymond C, Bergstrom B, Chen X, Das K, Dinh H, Kim ZS, Le AN, Lim MWJ, Pham JAN, Prusan JD, Rao SS, Nathanson DA, Ellingson BM. PMID: 33484366.
      View in: PubMed   Mentions:    Fields:    
    14. Relative oxygen extraction fraction (rOEF) MR imaging reveals higher hypoxia in human epidermal growth factor receptor (EGFR) amplified compared with non-amplified gliomas. Neuroradiology. 2021 Jun; 63(6):857-868. Oughourlian TC, Yao J, Yao J, Hagiwara A, Nathanson DA, Raymond C, Pope WB, Salamon N, Lai A, Ji M, Nghiemphu PL, Liau LM, Cloughesy TF, Ellingson BM. PMID: 33106922; PMCID: PMC8071834.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Associations Between Antihypertensive Medications and Severe Hyponatremia: A Swedish Population-Based Case-Control Study. J Clin Endocrinol Metab. 2020 10 01; 105(10). Falhammar H, Skov J, Calissendorff J, Nathanson D, Lindh JD, Mannheimer B. PMID: 32285124; PMCID: PMC7451505.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    16. Decorin expression is associated with predictive diffusion MR phenotypes of anti-VEGF efficacy in glioblastoma. Sci Rep. 2020 09 09; 10(1):14819. Patel KS, Yao J, Yao J, Raymond C, Yong W, Everson R, Liau LM, Nathanson D, Kornblum H, Wang C, Oughourlian T, Lai A, Nghiemphu PL, Pope WB, Cloughesy TF, Ellingson BM. PMID: 32908231; PMCID: PMC7481206.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    17. Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro Oncol. 2020 08 17; 22(8):1073-1113. Wen PY, Weller M, Lee EQ, Alexander BM, Barnholtz-Sloan JS, Barthel FP, Batchelor TT, Bindra RS, Chang SM, Chiocca EA, Cloughesy TF, DeGroot JF, Galanis E, Gilbert MR, Hegi ME, Horbinski C, Huang RY, Lassman AB, Le Rhun E, Lim M, Mehta MP, Mellinghoff IK, Minniti G, Nathanson D, Platten M, Preusser M, Roth P, Sanson M, Schiff D, Short SC, Taphoorn MJB, Tonn JC, Tsang J, Verhaak RGW, von Deimling A, Wick W, Zadeh G, Reardon DA, Aldape KD, van den Bent MJ. PMID: 32328653; PMCID: PMC7594557.
      View in: PubMed   Mentions: 265     Fields:    Translation:Humans
    18. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Med Chem Lett. 2020 Oct 08; 11(10):1799-1809. Tsang JE, Urner LM, Kim G, Chow K, Baufeld L, Faull K, Cloughesy TF, Clark PM, Jung ME, Nathanson DA. PMID: 33062157; PMCID: PMC7549123.
      View in: PubMed   Mentions: 7  
    19. Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma. Clin Cancer Res. 2020 07 01; 26(13):3135-3144. Ellingson BM, Yao J, Yao J, Raymond C, Nathanson DA, Chakhoyan A, Simpson J, Garner JS, Olivero AG, Mueller LU, Rodon J, Gerstner E, Cloughesy TF, Wen PY. PMID: 32269051; PMCID: PMC8204664.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    20. Factors of importance for discontinuation of thiazides associated with hyponatremia in Sweden: A population-based register study. Pharmacoepidemiol Drug Saf. 2020 01; 29(1):77-83. Fahl?n Bergh C, Toivanen S, Johnell K, Calissendorff J, Skov J, Falhammar H, Nathanson D, Lindh JD, Mannheimer B. PMID: 31730289.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI. Neuro Oncol. 2019 09 06; 21(9):1184-1196. Yao J, Yao J, Chakhoyan A, Nathanson DA, Yong WH, Salamon N, Raymond C, Mareninov S, Lai A, Nghiemphu PL, Prins RM, Pope WB, Everson RG, Liau LM, Cloughesy TF, Ellingson BM. PMID: 31066901; PMCID: PMC7594567.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    22. Tramadol- and codeine-induced severe hyponatremia: A Swedish population-based case-control study. Eur J Intern Med. 2019 Nov; 69:20-24. Falhammar H, Calissendorff J, Skov J, Nathanson D, Lindh JD, Mannheimer B. PMID: 31416660.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    23. PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation. Breast Cancer Res Treat. 2019 Nov; 178(1):75-86. Zhang L, Bailleul J, Yazal T, Dong K, Sung D, Dao A, Gosa L, Nathanson D, Bhat K, Duhachek-Muggy S, Alli C, Dratver MB, Pajonk F, Vlashi E. PMID: 31372790; PMCID: PMC6790295.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients. Elife. 2019 06 06; 8. Hu X, Matsumoto K, Jung RS, Weston TA, Heizer PJ, He C, Sandoval NP, Allan CM, Tu Y, Vinters HV, Liau LM, Ellison RM, Morales JE, Baufeld LJ, Bayley NA, He L, Betsholtz C, Beigneux AP, Nathanson DA, Gerhardt H, Young SG, Fong LG, Jiang H. PMID: 31169500; PMCID: PMC6594755.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma. Matrix Biol. 2020 01; 85-86:128-146. Xiao W, Wang S, Zhang R, Sohrabi A, Yu Q, Liu S, Ehsanipour A, Liang J, Bierman RD, Nathanson DA, Seidlits SK. PMID: 31028838; PMCID: PMC6813884.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    26. Correction: Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma. Cancer Res. 2019 Mar 15; 79(6):1260. Xiao W, Zhang R, Sohrabi A, Ehsanipour A, Sun S, Liang J, Walthers CM, Ta L, Nathanson DA, Seidlits SK. PMID: 30877102.
      View in: PubMed   Mentions:    Fields:    
    27. Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry. Sci Rep. 2019 02 26; 9(1):2846. Chakhoyan A, Yao J, Yao J, Leu K, Pope WB, Salamon N, Yong W, Lai A, Nghiemphu PL, Everson RG, Prins RM, Liau LM, Nathanson DA, Cloughesy TF, Ellingson BM. PMID: 30808879; PMCID: PMC6391482.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    28. Biosafety and Biohazards: Understanding Biosafety Levels and Meeting Safety Requirements of a Biobank. Methods Mol Biol. 2019; 1897:213-225. Ta L, Gosa L, Nathanson DA. PMID: 30539447; PMCID: PMC7120677.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    29. Processing of Primary Patient Tumors and Subsequent Generation of Primary Cell Lines. Methods Mol Biol. 2019; 1897:425-431. Gosa L, Ta L, Nathanson DA. PMID: 30539462.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    30. Antipsychotics and severe hyponatremia: A Swedish population-based case-control study. Eur J Intern Med. 2019 02; 60:71-77. Falhammar H, Lindh JD, Calissendorff J, Skov J, Nathanson D, Mannheimer B. PMID: 30514607.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    31. Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation. Clin Cancer Res. 2019 03 15; 25(6):1913-1922. Davidson TB, Lee A, Hsu M, Sedighim S, Orpilla J, Treger J, Mastall M, Roesch S, Rapp C, Galvez M, Mochizuki A, Antonios J, Garcia A, Kotecha N, Bayless N, Nathanson D, Wang A, Everson R, Yong WH, Cloughesy TF, Liau LM, Herold-Mende C, Prins RM. PMID: 30498094; PMCID: PMC6420851.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    32. Associations of proton pump inhibitors and hospitalization due to hyponatremia: A population-based case-control study. Eur J Intern Med. 2019 01; 59:65-69. Falhammar H, Lindh JD, Calissendorff J, Skov J, Nathanson D, Mannheimer B. PMID: 30154038.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    33. Surface Immobilization of Redox-Labile Fluorescent Probes: Enabling Single-Cell Co-Profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities. Angew Chem Int Ed Engl. 2018 09 03; 57(36):11554-11558. Li Z, Cheng H, Shao S, Lu X, Mo L, Tsang J, Zeng P, Guo Z, Wang S, Nathanson DA, Heath JR, Wei W, Xue M. PMID: 29992724; PMCID: PMC6443403.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    34. Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma. Cancer Res. 2018 03 01; 78(5):1358-1370. Xiao W, Zhang R, Sohrabi A, Ehsanipour A, Sun S, Liang J, Walthers CM, Ta L, Nathanson DA, Seidlits SK. PMID: 29282221; PMCID: PMC5935550.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    35. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017 Nov; 23(11):1342-1351. Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA. PMID: 29035366; PMCID: PMC5683421.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    36. Harnessing Preclinical Molecular Imaging to Inform Advances in Personalized Cancer Medicine. J Nucl Med. 2017 May; 58(5):689-696. Clark PM, Ebiana VA, Gosa L, Cloughesy TF, Nathanson DA. PMID: 28385796.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    37. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237; PMCID: PMC5334176.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansCells
    38. A Phase II Trial Exploring the Success of Cryoablation Therapy in the Treatment of Invasive Breast Carcinoma: Results from ACOSOG (Alliance) Z1072. Ann Surg Oncol. 2016 08; 23(8):2438-45. Simmons RM, Ballman KV, Cox C, Carp N, Sabol J, Hwang RF, Attai D, Sabel M, Nathanson D, Kenler A, Gold L, Kaufman C, Han L, Bleznak A, Stanley Smith J, Holmes D, Fornage B, Le-Petross C, Hoda S, McCall L, Hunt KK, ACOSOG investigators. PMID: 27221361; PMCID: PMC5433250.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCTClinical Trials
    39. Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma. Mol Cancer Ther. 2016 06; 15(6):1271-8. Laks DR, Ta L, Crisman TJ, Gao F, Coppola G, Radu CG, Nathanson DA, Kornblum HI. PMID: 27196770; PMCID: PMC4893966.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    40. Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma. Curr Neurol Neurosci Rep. 2016 Feb; 16(2):17. Clark PM, Mai WX, Cloughesy TF, Nathanson DA. PMID: 26759318.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    41. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 2015 Sep 01; 22(3):508-15. Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J. PMID: 26190651; PMCID: PMC4663076.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    42. Quantitative assessments of glycolysis from single cells. Technology (Singap World Sci). 2015 Jun; 3(4):172-178. Shin YS, Kim J, Johnson D, Dooraghi AA, Mai WX, Ta L, Chatziioannou AF, Phelps ME, Nathanson DA, Heath JR. PMID: 26835505; PMCID: PMC4728151.
      View in: PubMed   Mentions: 1  
    43. Chemical methods for the simultaneous quantitation of metabolites and proteins from single cells. J Am Chem Soc. 2015 Apr 01; 137(12):4066-9. Xue M, Wei W, Su Y, Kim J, Shin YS, Mai WX, Nathanson DA, Heath JR. PMID: 25789560; PMCID: PMC4883658.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    44. Fully automated production of diverse 18F-labeled PET tracers on the ELIXYS multireactor radiosynthesizer without hardware modification. J Nucl Med Technol. 2014 Sep; 42(3):203-10. Lazari M, Collins J, Shen B, Farhoud M, Yeh D, Maraglia B, Chin FT, Nathanson DA, Moore M, van Dam RM. PMID: 25033883; PMCID: PMC4491436.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    45. Linagliptin enhances neural stem cell proliferation after stroke in type 2 diabetic mice. Regul Pept. 2014 May; 190-191:25-31. Darsalia V, Olverling A, Larsson M, Mansouri S, Nathanson D, Nyström T, Klein T, Sjöholm Å, Patrone C. PMID: 24821550.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    46. The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia. Dis Model Mech. 2014 Jul; 7(7):895-905. Danilova N, Bibikova E, Covey TM, Nathanson D, Dimitrova E, Konto Y, Lindgren A, Glader B, Radu CG, Sakamoto KM, Lin S. PMID: 24812435; PMCID: PMC4073278.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    47. Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J Exp Med. 2014 Mar 10; 211(3):473-86. Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. PMID: 24567448; PMCID: PMC3949575.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCellsPHPublic Health
    48. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science. 2014 Jan 03; 343(6166):72-6. Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, Mischel PS. PMID: 24310612; PMCID: PMC4049335.
      View in: PubMed   Mentions: 256     Fields:    Translation:HumansAnimalsCells
    49. The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clin Cancer Res. 2013 Oct 15; 19(20):5722-32. Gini B, Zanca C, Guo D, Matsutani T, Masui K, Ikegami S, Yang H, Nathanson D, Villa GR, Shackelford D, Zhu S, Tanaka K, Babic I, Akhavan D, Lin K, Assuncao A, Gu Y, Bonetti B, Mortensen DS, Xu S, Raymon HK, Cavenee WK, Furnari FB, James CD, Kroemer G, Heath JR, Hege K, Chopra R, Cloughesy TF, Mischel PS. PMID: 24030701; PMCID: PMC3815450.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    50. Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system. J Nucl Med. 2013 Oct; 54(10):1820-4. Wang J, Hwang K, Braas D, Dooraghi A, Nathanson D, Campbell DO, Gu Y, Sandberg T, Mischel P, Radu C, Chatziioannou AF, Phelps ME, Christofk H, Heath JR. PMID: 23978446; PMCID: PMC4106462.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    51. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem. 2013 Sep 12; 56(17):6696-708. Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. PMID: 23947754; PMCID: PMC3789385.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    52. EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell Metab. 2013 Jun 04; 17(6):1000-1008. Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee WK, Cloughesy TF, Christofk HR, Black DL, Mischel PS. PMID: 23707073; PMCID: PMC3679227.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    53. PET/CT in Oncology: Current Status and Perspectives. Curr Radiol Rep. 2013; 1:177-190. Czernin J, Allen-Auerbach M, Nathanson D, Herrmann K. PMID: 24883234; PMCID: PMC4034170.
      View in: PubMed   Mentions: 28  
    54. Evaluation of the Genisys4, a bench-top preclinical PET scanner. J Nucl Med. 2013 Jul; 54(7):1162-7. Herrmann K, Dahlbom M, Nathanson D, Wei L, Radu C, Chatziioannou A, Czernin J. PMID: 23628700; PMCID: PMC3790646.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    55. De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discov. 2013 May; 3(5):534-47. Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS. PMID: 23533263; PMCID: PMC3651754.
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    56. Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Cancer Discov. 2012 Dec; 2(12):1109-17. Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR. PMID: 23230188; PMCID: PMC3531869.
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    57. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med. 2012 Nov 19; 209(12):2215-28. Austin WR, Armijo AL, Campbell DO, Singh AS, Hsieh T, Nathanson D, Herschman HR, Phelps ME, Witte ON, Czernin J, Radu CG. PMID: 23148236; PMCID: PMC3501349.
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    58. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14164-9. Fenton TR, Nathanson D, Ponte de Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo SM, Uno M, Inda MM, Wykosky J, Bachoo RM, James CD, DePinho RA, Vandenberg SR, Zhou H, Marie SK, Mischel PS, Cavenee WK, Furnari FB. PMID: 22891331; PMCID: PMC3435194.
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    59. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discov. 2011 Oct; 1(5):442-56. Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, Kuga D, Amzajerdi AN, Soto H, Zhu S, Babic I, Tanaka K, Dang J, Iwanami A, Gini B, Dejesus J, Lisiero DD, Huang TT, Prins RM, Wen PY, Robins HI, Prados MD, Deangelis LM, Mellinghoff IK, Mehta MP, James CD, Chakravarti A, Cloughesy TF, Tontonoz P, Mischel PS. PMID: 22059152; PMCID: PMC3207317.
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    60. Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance. Cancer Discov. 2011 Nov; 1(6):524-38. Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, De Jesus J, Amzajerdi AN, Zhang Y, Dibble CC, Dan H, Rinkenbaugh A, Yong WH, Vinters HV, Gera JF, Cavenee WK, Cloughesy TF, Manning BD, Baldwin AS, Mischel PS. PMID: 22145100; PMCID: PMC3229221.
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    61. Charting the course across the blood-brain barrier. J Clin Invest. 2011 Jan; 121(1):31-3. Nathanson D, Mischel PS. PMID: 21183784; PMCID: PMC3007172.
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    62. A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer Res. 2010 Aug 01; 70(15):6128-38. Sun J, Masterman-Smith MD, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, DeJesus J, Kamei K, Lee KB, Wang H, Yu ZT, Lu YT, Hou S, Li K, Liu M, Zhang N, Wang S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathanson D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI, Yong WH, Graeber TG, Tseng HR. PMID: 20631065; PMCID: PMC3163840.
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    63. An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. Curr Biol. 2009 Nov 17; 19(21):1788-98. Tarcic G, Boguslavsky SK, Wakim J, Kiuchi T, Liu A, Reinitz F, Nathanson D, Takahashi T, Mischel PS, Ng T, Yarden Y. PMID: 19836242; PMCID: PMC2783429.
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    64. Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples. Clin Cancer Res. 2008 Jan 15; 14(2):488-93. Yoshimoto K, Dang J, Zhu S, Nathanson D, Huang T, Dumont R, Seligson DB, Yong WH, Xiong Z, Rao N, Winther H, Chakravarti A, Bigner DD, Mellinghoff IK, Horvath S, Cavenee WK, Cloughesy TF, Mischel PS. PMID: 18223223.
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    65. Timeline of tibial tunnel expansion after single-incision hamstring anterior cruciate ligament reconstruction. Arthroscopy. 2004 Jan; 20(1):34-6. Buck DC, Simonian PT, Larson RV, Borrow J, Nathanson DA. PMID: 14716276.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
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