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Scalable droplet-based radiosynthesis of [18F]fluorobenzyltriphenylphosphonium cation ([18F]FBnTP) via a "numbering up" approach. Lab Chip. 2024 02 13; 24(4):728-737.
Lu Y, Collins J, Lin KS, van Dam RM. PMID: 38240629; PMCID: PMC10869106.
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PubMed Mentions:
1 Fields:
-
Detrimental impact of aqueous mobile phases on 18F-labelled radiopharmaceutical analysis via radio-TLC. Anal Methods. 2023 01 19; 15(3):377-387.
Laferriere-Holloway TS, Rios A, van Dam RM. PMID: 36542448; PMCID: PMC9891729.
View in:
PubMed Mentions:
2 Fields:
-
Microliter-scale reaction arrays for economical high-throughput experimentation in radiochemistry. Sci Rep. 2022 06 17; 12(1):10263.
Rios A, Holloway TS, Chao PH, De Caro C, Okoro CC, van Dam RM. PMID: 35715457; PMCID: PMC9205965.
View in:
PubMed Mentions:
5 Fields:
-
Highlight selection of radiochemistry and radiopharmacy developments by editorial board. EJNMMI Radiopharm Chem. 2022 Apr 26; 7(1):9.
Bernardes E, Caravan P, van Dam RM, Deuther-Conrad W, Ellis B, Furumoto S, Guillet B, Huang YY, Jia H, Laverman P, Li Z, Liu Z, Lodi F, Miao Y, Perk L, Schirrmacher R, Vercoullie J, Yang H, Yang M, Yang X, Zhang J, Zhang MR, Zhu H. PMID: 35471681; PMCID: PMC9043146.
View in:
PubMed Mentions:
1
-
Economical Production of Radiopharmaceuticals for Preclinical Imaging Using Microdroplet Radiochemistry. Methods Mol Biol. 2022; 2393:813-828.
Wang J, van Dam RM. PMID: 34837213.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
-
Economical droplet-based microfluidic production of [18F]FET and [18F]Florbetaben suitable for human use. Sci Rep. 2021 10 19; 11(1):20636.
Lisova K, Wang J, Hajagos TJ, Lu Y, Hsiao A, Elizarov A, van Dam RM. PMID: 34667246; PMCID: PMC8526601.
View in:
PubMed Mentions:
8 Fields:
Translation:
Humans
-
Cerenkov Luminescence Imaging in the Development and Production of Radiopharmaceuticals. Front Phys. 2021; 9.
van Dam RM, Chatziioannou AF. PMID: 36213527; PMCID: PMC9544387.
View in:
PubMed Mentions:
1
-
Optimization of Radiochemical Reactions using Droplet Arrays. J Vis Exp. 2021 02 12; (168).
Rios A, Holloway TS, Wang J, van Dam RM. PMID: 33645586; PMCID: PMC8253531.
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PubMed Mentions: Fields:
-
A simple and efficient automated microvolume radiosynthesis of [18F]Florbetaben. EJNMMI Radiopharm Chem. 2020 Dec 04; 5(1):30.
Lisova K, Wang J, Chao PH, van Dam RM. PMID: 33275179; PMCID: PMC7718361.
View in:
PubMed Mentions:
4
-
Multi-GBq production of the radiotracer [18F]fallypride in a droplet microreactor. RSC Adv. 2020 Feb 18; 10(13):7828-7838.
Wang J, Chao PH, Slavik R, van Dam RM. PMID: 35492189; PMCID: PMC9049805.
View in:
PubMed Mentions:
12
-
Integration of High-Resolution Radiation Detector for Hybrid Microchip Electrophoresis. Anal Chem. 2020 02 18; 92(4):3483-3491.
Jones J, Ha NS, Barajas AG, Chatziioannou AF, van Dam RM. PMID: 31986878; PMCID: PMC7410349.
View in:
PubMed Mentions: Fields:
-
High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress. Mol Imaging. 2020 Jan-Dec; 19:1536012120973099.
Wang J, van Dam RM. PMID: 33296272; PMCID: PMC7731702.
View in:
PubMed Mentions:
12 Fields:
-
Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET). EJNMMI Radiopharm Chem. 2019 Dec 31; 5(1):1.
Lisova K, Chen BY, Wang J, Fong KM, Clark PM, van Dam RM. PMID: 31893318; PMCID: PMC6938530.
View in:
PubMed Mentions:
8
-
High-throughput radio-TLC analysis. Nucl Med Biol. 2020 Mar - Apr; 82-83:41-48.
Wang J, Rios A, Lisova K, Slavik R, Chatziioannou AF, van Dam RM. PMID: 31891883; PMCID: PMC6956702.
View in:
PubMed Mentions:
17 Fields:
-
Green and efficient synthesis of the radiopharmaceutical [18F]FDOPA using a microdroplet reactor. React Chem Eng. 2020 Feb 01; 5(2):320-329.
Wang J, Holloway T, Lisova K, van Dam RM. PMID: 34164154; PMCID: PMC8218909.
View in:
PubMed Mentions:
10
-
In vivo characterization of [18F]AVT-011 as a radiotracer for PET imaging of multidrug resistance. Eur J Nucl Med Mol Imaging. 2020 07; 47(8):2026-2035.
Kannan P, Füredi A, Dizdarevic S, Wanek T, Mairinger S, Collins J, Falls T, van Dam RM, Maheshwari D, Lee JT, Szakács G, Langer O. PMID: 31729540; PMCID: PMC7299908.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Ionic-surfactant-mediated electro-dewetting for digital microfluidics. Nature. 2019 08; 572(7770):507-510.
Li J, Ha NS, Liu T', van Dam RM, 'cj' Kim CJ. PMID: 31435058.
View in:
PubMed Mentions:
48 Fields:
-
A novel multi-reaction microdroplet platform for rapid radiochemistry optimization. RSC Adv. 2019 Jun 25; 9(35):20370-20374.
Rios A, Wang J, Chao PH, van Dam RM. PMID: 35514735; PMCID: PMC9065505.
View in:
PubMed Mentions:
10
-
Ultra-compact, automated microdroplet radiosynthesizer. Lab Chip. 2019 07 21; 19(14):2415-2424.
Wang J, Chao PH, van Dam RM. PMID: 31187109; PMCID: PMC7416997.
View in:
PubMed Mentions:
22 Fields:
-
The Search for an Alternative to [68Ga]Ga-DOTA-TATE in Neuroendocrine Tumor Theranostics: Current State of 18F-labeled Somatostatin Analog Development. Theranostics. 2019; 9(5):1336-1347.
Waldmann CM, Stuparu AD, van Dam RM, Slavik R. PMID: 30867834; PMCID: PMC6401503.
View in:
PubMed Mentions:
28 Fields:
Translation:
Humans
-
18F-labeled anti-human CD20 cys-diabody for same-day immunoPET in a model of aggressive B cell lymphoma in human CD20 transgenic mice. Eur J Nucl Med Mol Imaging. 2019 02; 46(2):489-500.
Zettlitz KA, Tavaré R, Tsai WK, Yamada RE, Ha NS, Collins J, van Dam RM, Timmerman JM, Wu AM. PMID: 30456475; PMCID: PMC6580847.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimals
-
Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production. J Vis Exp. 2018 10 26; (140).
Schopf E, Waldmann CM, Collins J, Drake C, Slavik R, van Dam RM. PMID: 30417868; PMCID: PMC6235612.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
-
Automated concentration of [18F]fluoride into microliter volumes. Appl Radiat Isot. 2018 Nov; 141:138-148.
Chao PH, Lazari M, Hanet S, Narayanam MK, Murphy JM, van Dam RM. PMID: 30243135; PMCID: PMC6502507.
View in:
PubMed Mentions:
14 Fields:
-
Microscale radiosynthesis, preclinical imaging and dosimetry study of [18F]AMBF3-TATE: A potential PET tracer for clinical imaging of somatostatin receptors. Nucl Med Biol. 2018 06; 61:36-44.
Lisova K, Sergeev M, Evans-Axelsson S, Stuparu AD, Beykan S, Collins J, Jones J, Lassmann M, Herrmann K, Perrin D, Lee JT, Slavik R, van Dam RM. PMID: 29747035; PMCID: PMC6015542.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography. Commun Chem. 2018; 1(1).
Sergeev ME, Lazari M, Morgia F, Collins J, Javed MR, Sergeeva O, Jones J, Phelps ME, Lee JT, Keng PY, van Dam RM. PMID: 34291178; PMCID: PMC8291036.
View in:
PubMed Mentions:
28
-
Toward miniaturized analysis of chemical identity and purity of radiopharmaceuticals via microchip electrophoresis. Anal Bioanal Chem. 2018 Mar; 410(9):2423-2436.
Ly J, Ha NS, Cheung S, van Dam RM. PMID: 29470664; PMCID: PMC6482050.
View in:
PubMed Mentions:
3 Fields:
-
Performing multi-step chemical reactions in microliter-sized droplets by leveraging a simple passive transport mechanism. Lab Chip. 2017 12 05; 17(24):4342-4355.
Wang J, Chao PH, Hanet S, van Dam RM. PMID: 29164208; PMCID: PMC6530551.
View in:
PubMed Mentions:
21 Fields:
Translation:
Animals
-
Recent Progress toward Microfluidic Quality Control Testing of Radiopharmaceuticals. Micromachines (Basel). 2017 Nov 21; 8(11).
Ha NS, Sadeghi S, van Dam RM. PMID: 30400527; PMCID: PMC6190332.
View in:
PubMed Mentions:
10
-
Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):11309-11314.
Collins J, Waldmann CM, Drake C, Slavik R, Ha NS, Sergeev M, Lazari M, Shen B, Chin FT, Moore M, Sadeghi S, Phelps ME, Murphy JM, van Dam RM. PMID: 29073049; PMCID: PMC5664529.
View in:
PubMed Mentions:
22 Fields:
-
Novel volumetric method for highly repeatable injection in microchip electrophoresis. Anal Chim Acta. 2017 Sep 08; 985:129-140.
Ha NS, Ly J, Jones J, Cheung S, van Dam RM. PMID: 28864183; PMCID: PMC5657552.
View in:
PubMed Mentions:
5 Fields:
-
Automatic concentration and reformulation of PET tracers via microfluidic membrane distillation. Lab Chip. 2017 05 16; 17(10):1802-1816.
Chao PH, Collins J, Argus JP, Tseng WY, Lee JT, Michael van Dam R. . PMID: 28443841; PMCID: PMC5497730.
View in:
PubMed Mentions:
6 Fields:
-
Comparative Analysis of Human Nucleoside Kinase-Based Reporter Systems for PET Imaging. Mol Imaging Biol. 2017 02; 19(1):100-108.
Lee JT, Zhang H, Moroz MA, Likar Y, Shenker L, Sumzin N, Lobo J, Zurita J, Collins J, van Dam RM, Ponomarev V. PMID: 27393689; PMCID: PMC5345744.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
-
ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes. EJNMMI Res. 2016 Dec; 6(1):22.
Dooraghi AA, Carroll L, Collins J, van Dam RM, Chatziioannou AF. PMID: 26956805; PMCID: PMC4783308.
View in:
PubMed Mentions:
2
-
A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging. Organometallics. 2016 Apr 11; 35(7):1008-1014.
Hoover AJ, Lazari M, Ren H, Narayanam MK, Murphy JM, van Dam RM, Hooker JM, Ritter T. PMID: 27087736; PMCID: PMC4829938.
View in:
PubMed Mentions:
25
-
Understanding temperatures and pressures during short radiochemical reactions. Appl Radiat Isot. 2016 Feb; 108:82-91.
Lazari M, Irribarren J, Zhang S, van Dam RM. PMID: 26706993.
View in:
PubMed Mentions:
5 Fields:
-
Digital Microfluidics: A New Paradigm for Radiochemistry. Mol Imaging. 2015 12 05; 14(12):13-14.
Keng PY, van Dam RM. PMID: 26650206; PMCID: PMC4734895.
View in:
PubMed Mentions:
20 Fields:
-
On-demand generation and mixing of liquid-in-gas slugs with digitally-programmable composition and size. J Micromech Microeng. 2015 Aug; 25(8).
Chen YC, Liu K, Shen CK, van Dam RM. PMID: 29167603; PMCID: PMC5695874.
View in:
PubMed Mentions:
4
-
Fully-automated synthesis of 16β-(18)F-fluoro-5α-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer. Appl Radiat Isot. 2015 Sep; 103:9-14.
Lazari M, Lyashchenko SK, Burnazi EM, Lewis JS, van Dam RM, Murphy JM. PMID: 26046518; PMCID: PMC4530021.
View in:
PubMed Mentions:
5 Fields:
-
Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium. J Am Chem Soc. 2015 May 06; 137(17):5686-94.
Sergeev ME, Morgia F, Lazari M, Wang C, van Dam RM. PMID: 25860121; PMCID: PMC4485375.
View in:
PubMed Mentions:
16 Fields:
Translation:
Cells
-
Fully automated production of diverse 18F-labeled PET tracers on the ELIXYS multireactor radiosynthesizer without hardware modification. J Nucl Med Technol. 2014 Sep; 42(3):203-10.
Lazari M, Collins J, Shen B, Farhoud M, Yeh D, Maraglia B, Chin FT, Nathanson DA, Moore M, van Dam RM. PMID: 25033883; PMCID: PMC4491436.
View in:
PubMed Mentions:
21 Fields:
Translation:
Animals
-
Compact microfluidic device for rapid concentration of PET tracers. Lab Chip. 2014 Jul 07; 14(13):2293-302.
Tseng WY, van Dam RM. PMID: 24825578; PMCID: PMC4465334.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
Radiolabelling diverse positron emission tomography (PET) tracers using a single digital microfluidic reactor chip. Lab Chip. 2014 Mar 07; 14(5):902-10.
Chen S, Javed MR, Kim HK, Lei J, Lazari M, Shah GJ, van Dam RM, Keng PY, Kim CJ. PMID: 24352530.
View in:
PubMed Mentions:
18 Fields:
-
High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging. Chem Commun (Camb). 2014 Feb 07; 50(10):1192-4.
Javed MR, Chen S, Lei J, Collins J, Sergeev M, Kim HK, Kim CJ, van Dam RM, Keng PY. PMID: 24326303; PMCID: PMC4479166.
View in:
PubMed Mentions:
16 Fields:
-
The separation and detection of PET tracers via capillary electrophoresis for chemical identity and purity analysis. J Pharm Biomed Anal. 2014 Jun; 94:12-8.
Cheung S, Ly J, Lazari M, Sadeghi S, Keng PY, van Dam RM. PMID: 24534300.
View in:
PubMed Mentions:
6 Fields:
-
Efficient radiosynthesis of 3'-deoxy-3'-18F-fluorothymidine using electrowetting-on-dielectric digital microfluidic chip. J Nucl Med. 2014 Feb; 55(2):321-8.
Javed MR, Chen S, Kim HK, Wei L, Czernin J, Kim CJ, van Dam RM, Keng PY. PMID: 24365651; PMCID: PMC4494735.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
-
A microreactor with phase-change microvalves for batch chemical synthesis at high temperatures and pressures. Lab Chip. 2014 Jan 21; 14(2):280-5.
Ma X, Tseng WY, Eddings M, Keng PY, van Dam RM. PMID: 24253219.
View in:
PubMed Mentions:
1 Fields:
-
Optimization of microfluidic PET tracer synthesis with Cerenkov imaging. Analyst. 2013 Oct 07; 138(19):5654-64.
Dooraghi AA, Keng PY, Chen S, Javed MR, Kim CJ, Chatziioannou AF, van Dam RM. PMID: 23928799; PMCID: PMC3812546.
View in:
PubMed Mentions:
19 Fields:
-
Automated reagent-dispensing system for microfluidic cell biology assays. J Lab Autom. 2013 Dec; 18(6):530-41.
Ly J, Masterman-Smith M, Ramakrishnan R, Sun J, Kokubun B, van Dam RM. PMID: 24051515.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
-
On-demand droplet loading for automated organic chemistry on digital microfluidics. Lab Chip. 2013 Jul 21; 13(14):2785-95.
Shah GJ, Ding H, Sadeghi S, Chen S, Kim CJ, van Dam RM. PMID: 23670035.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
Simplified programming and control of automated radiosynthesizers through unit operations. EJNMMI Res. 2013 Jul 15; 3(1):53.
Claggett SB, Quinn KM, Lazari M, Moore MD, van Dam RM. PMID: 23855995; PMCID: PMC3717018.
View in:
PubMed Mentions:
5
-
ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diverse PET tracers. EJNMMI Res. 2013 Jul 12; 3(1):52.
Lazari M, Quinn KM, Claggett SB, Collins J, Shah GJ, Herman HE, Maraglia B, Phelps ME, Moore MD, van Dam RM. PMID: 23849185; PMCID: PMC3717127.
View in:
PubMed Mentions:
15
-
Reusable electrochemical cell for rapid separation of [¹⁸F]fluoride from [¹⁸O]water for flow-through synthesis of ¹⁸F-labeled tracers. Appl Radiat Isot. 2013 May; 75:85-94.
Sadeghi S, Liang V, Cheung S, Woo S, Wu C, Ly J, Deng Y, Eddings M, van Dam RM. PMID: 23474380; PMCID: PMC4485997.
View in:
PubMed Mentions:
7 Fields:
Translation:
PHPublic Health
-
Accurate dispensing of volatile reagents on demand for chemical reactions in EWOD chips. Lab Chip. 2012 Sep 21; 12(18):3331-40.
Ding H, Sadeghi S, Shah GJ, Chen S, Keng PY, Kim CJ, van Dam RM. PMID: 22825699; PMCID: PMC4489852.
View in:
PubMed Mentions:
8 Fields:
-
On chip droplet characterization: a practical, high-sensitivity measurement of droplet impedance in digital microfluidics. Anal Chem. 2012 Feb 21; 84(4):1915-23.
Sadeghi S, Ding H, Shah GJ, Chen S, Keng PY, Kim CJ, van Dam RM. PMID: 22248060.
View in:
PubMed Mentions:
10 Fields:
-
Micro-chemical synthesis of molecular probes on an electronic microfluidic device. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):690-5.
Keng PY, Chen S, Ding H, Sadeghi S, Shah GJ, Dooraghi A, Phelps ME, Satyamurthy N, Chatziioannou AF, Kim CJ, van Dam RM. PMID: 22210110; PMCID: PMC3271918.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
-
Flow optimization study of a batch microfluidics PET tracer synthesizing device. Biomed Microdevices. 2011 Feb; 13(1):231-42.
Elizarov AM, Meinhart C, Miraghaie R, van Dam RM, Huang J, Daridon A, Heath JR, Kolb HC. PMID: 21072595; PMCID: PMC3028087.
View in:
PubMed Mentions:
3 Fields:
-
A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer Res. 2010 Aug 01; 70(15):6128-38.
Sun J, Masterman-Smith MD, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, DeJesus J, Kamei K, Lee KB, Wang H, Yu ZT, Lu YT, Hou S, Li K, Liu M, Zhang N, Wang S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathanson D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI, Yong WH, Graeber TG, Tseng HR. PMID: 20631065; PMCID: PMC3163840.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansCells
-
Microfluidic device for robust generation of two-component liquid-in-air slugs with individually controlled composition. Microfluid Nanofluidics. 2010 Oct; 9(4-5):933-943.
Liu K, Chen YC, Tseng HR, Shen CK, van Dam RM. PMID: 20930933; PMCID: PMC2944379.
View in:
PubMed Mentions:
8
-
Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis. J Nucl Med. 2010 Feb; 51(2):282-7.
Elizarov AM, van Dam RM, Shin YS, Kolb HC, Padgett HC, Stout D, Shu J, Huang J, Daridon A, Heath JR. PMID: 20124050; PMCID: PMC3000316.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimals
-
Cerenkov radiation imaging as a method for quantitative measurements of beta particles in a microfluidic chip. Phys Med Biol. 2009 Nov 21; 54(22):6757-71.
Cho JS, Taschereau R, Olma S, Liu K, Chen YC, Shen CK, van Dam RM, Chatziioannou AF. PMID: 19847018; PMCID: PMC2794558.
View in:
PubMed Mentions:
38 Fields:
-
Design and fabrication of chemically robust three-dimensional microfluidic valves. Lab Chip. 2007 Sep; 7(9):1209-11.
Maltezos G, Garcia E, Hanrahan G, Gomez FA, Vyawahare S, Vyawhare S, van Dam RM, Chen Y, Scherer A. PMID: 17713623.
View in:
PubMed Mentions:
6 Fields:
-
Solvent-resistant photocurable liquid fluoropolymers for microfluidic device fabrication [corrected]. J Am Chem Soc. 2004 Mar 03; 126(8):2322-3.
Rolland JP, Van Dam RM, Schorzman DA, Quake SR, DeSimone JM. PMID: 14982433.
View in:
PubMed Mentions:
57 Fields:
-
Microfabricated fountain pens for high-density DNA arrays. Genome Res. 2003 Oct; 13(10):2348-52.
Reese MO, van Dam RM, Scherer A, Quake SR. PMID: 12975313; PMCID: PMC403724.
View in:
PubMed Mentions:
3 Fields:
-
Gene expression analysis with universal n-mer arrays. Genome Res. 2002 Jan; 12(1):145-52.
van Dam RM, Quake SR. PMID: 11779839; PMCID: PMC155258.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells