Harley I Kornblum

Title(s)Professor-in-Residence, Psychiatry and Biobehavioral Sciences
SchoolMedicine
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    Other Positions
    Title(s)Professor-in-Residence, Molecular and Medical Pharmacology


    Collapse Research 
    Collapse Research Activities and Funding
    UCLA IDDRC
    NIH P50HD103557Aug 1, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Stem cell- based studies of gene-environment interactions in PTEN- associated autism
    NIH R21HD084204Sep 1, 2016 - Aug 31, 2018
    Role: Principal Investigator
    Neural Progenitor Genes and Brain Tumors
    NIH R01NS052563Jul 1, 2005 - Mar 31, 2017
    Role: Principal Investigator
    Neural Progenitor Genes and Brain Tumors
    NIH R56NS052563Jul 1, 2005 - Mar 31, 2011
    Role: Principal Investigator
    A Proteomic Analysis of Neural Progenitors
    NIH R21MH068649Jul 1, 2003 - Jun 30, 2005
    Role: Principal Investigator
    Identity and Function of CNS Progenitor Cell Genes
    NIH R01MH065756Sep 21, 2001 - Apr 30, 2009
    Role: Principal Investigator
    GENE EXPRESSION IN CNS PROGENITORS
    NIH R21MH062800Sep 19, 2000 - Aug 31, 2002
    Role: Principal Investigator
    GROWTH FACTORS IN BRAIN PLASTICITY AND DEVELOPMENT
    NIH K08NS001837Apr 29, 1996 - Feb 28, 2001
    Role: Principal Investigator
    DEVELOPMENT AND ROLE OF SUPPORTING CELLS IN THE INNER EA
    NIH F32NS007874Sep 1, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Valproic acid targets IDH1 mutants through alteration of lipid metabolism. NPJ Metab Health Dis. 2024; 2(1):20. Elahi LS, Condro MC, Kawaguchi R, Qin Y, Alvarado AG, Gruender B, Qi H, Li T, Lai A, Castro MG, Lowenstein PR, Garrett MC, Kornblum HI. PMID: 39149696; PMCID: PMC11321993.
      View in: PubMed   Mentions:
    2. Valproic acid targets IDH1 mutants through alteration of lipid metabolism. NPJ Metab Health Dis. 2024; 2(1):20. Elahi LS, Condro MC, Kawaguchi R, Qin Y, Alvarado AG, Gruender B, Qi H, Li T, Lai A, Castro MG, Lowenstein PR, Garrett MC, Kornblum HI. PMID: 39149696; PMCID: PMC11321993.
      View in: PubMed   Mentions:
    3. Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth. Mol Cancer Res. 2024 07 02; 22(7):656-667. Muthukrishnan SD, Qi H, Wang D, Elahi L, Pham A, Alvarado AG, Li T, Gao F, Kawaguchi R, Lai A, Kornblum HI. PMID: 38441553; PMCID: PMC11217726.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1. Cancer Res Commun. 2024 Jun 25; 4(6):1566-1580. He L, Ioannidis A, Hoffman CJ, Arambula E, Joshi P, Whitelegge J, Liau LM, Kornblum HI, Pajonk F. PMID: 38837899; PMCID: PMC11197925.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Radiation-Induced Cellular Plasticity: A Strategy for Combatting Glioblastoma. bioRxiv. 2024 May 16. He L, Azizad D, Bhat K, Ioannidis A, Hoffmann CJ, Arambula E, Bhaduri A, Kornblum HI, Pajonk F. PMID: 38798647; PMCID: PMC11118449.
      View in: PubMed   Mentions:
    6. D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation. Cancer Res Commun. 2024 Mar 22; 4(3):876-894. Pianka ST, Li T, Prins TJ, Eldred BSC, Kevan BM, Liang H, Zapanta Rinonos S, Kornblum HI, Nathanson DA, Pellegrini M, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. PMID: 38445960; PMCID: PMC10959073.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Single-nucleus expression characterization of non-enhancing region of recurrent high-grade glioma. Neurooncol Adv. 2024 Jan-Dec; 6(1):vdae005. Patel KS, Tessema KK, Kawaguchi R, Dudley L, Alvarado AG, Muthukrishnan SD, Perryman T, Hagiwara A, Swarup V, Liau LM, Wang AC, Yong W, Geschwind DH, Nakano I, Goldman SA, Everson RG, Ellingson BM, Kornblum HI. PMID: 38616896; PMCID: PMC11012612.
      View in: PubMed   Mentions:
    8. pH-Weighted amine chemical exchange saturation transfer echo planar imaging visualizes infiltrating glioblastoma cells. Neuro Oncol. 2024 01 05; 26(1):115-126. Patel KS, Yao J, Cho NS, Sanvito F, Tessema K, Alvarado A, Dudley L, Rodriguez F, Everson R, Cloughesy TF, Salamon N, Liau LM, Kornblum HI, Ellingson BM. PMID: 37591790; PMCID: PMC10768991.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance. Neuro Oncol. 2023 11 02; 25(11):1989-2000. Bailleul J, Ruan Y, Abdulrahman L, Scott AJ, Yazal T, Sung D, Park K, Hoang H, Nathaniel J, Chu FI, Palomera D, Sehgal A, Tsang JE, Nathanson DA, Xu S, Park JO, Ten Hoeve J, Bhat K, Qi N, Kornblum HI, Schaue D, McBride WH, Lyssiotis CA, Wahl DR, Vlashi E. PMID: 37279645; PMCID: PMC10628945.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. Nicotinamide Adenine Dinucleotide Phosphate Oxidase Promotes Glioblastoma Radiation Resistance in a Phosphate and Tensin Homolog-Dependent Manner. Antioxid Redox Signal. 2023 11; 39(13-15):890-903. Ludwig K, Le Belle JE, Muthukrishnan SD, Sperry J, Condro M, Vlashi E, Pajonk F, Kornblum HI. PMID: 37470216; PMCID: PMC10775910.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Microenvironmental stiffness induces metabolic reprogramming in glioblastoma. Cell Rep. 2023 10 31; 42(10):113175. Sohrabi A, Lefebvre AEYT, Harrison MJ, Condro MC, Sanazzaro TM, Safarians G, Solomon I, Bastola S, Kordbacheh S, Toh N, Kornblum HI, Digman MA, Seidlits SK. PMID: 37756163; PMCID: PMC10842372.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Sci Rep. 2023 08 01; 13(1):12433. Garrett MC, Albano R, Carnwath T, Elahi L, Behrmann CA, Pemberton M, Woo D, O'Brien E, VanCauwenbergh B, Perentesis J, Shah S, Hagan M, Kendler A, Zhao C, Paranjpe A, Roskin K, Kornblum H, Plas DR, Lu QR. PMID: 37528157; PMCID: PMC10394035.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1. bioRxiv. 2023 Jul 25. He L, Ioannidis A, Arambula E, Hoffman CJ, Joshi P, Kathiravan A, Whitelegge J, Liau LM, Kornblum HI, Pajonk F. PMID: 37546917; PMCID: PMC10402033.
      View in: PubMed   Mentions:
    14. Low- and high-grade glioma endothelial cells differentially regulate tumor growth. bioRxiv. 2023 Jul 07. Muthukrishnan SD, Qi H, Wang D, Elahi L, Pham A, Alvarado AG, Li T, Gao F, Kawaguchi R, Lai A, Kornblum HI. PMID: 37461434; PMCID: PMC10350040.
      View in: PubMed   Mentions:
    15. (R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers. Cancer Discov. 2023 06 02; 13(6):1478-1497. Gunn K, Myllykoski M, Cao JZ, Ahmed M, Huang B, Rouaisnel B, Diplas BH, Levitt MM, Looper R, Doench JG, Ligon KL, Kornblum HI, McBrayer SK, Yan H, Duy C, Godley LA, Koivunen P, Losman JA. PMID: 36847506; PMCID: PMC10238656.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    16. Glioblastoma Spheroid Invasion through Soft, Brain-Like Matrices Depends on Hyaluronic Acid-CD44 Interactions. Adv Healthc Mater. 2023 06; 12(14):e2203143. Safarians G, Sohrabi A, Solomon I, Xiao W, Bastola S, Rajput BW, Epperson M, Rosenzweig I, Tamura K, Singer B, Huang J, Harrison MJ, Sanazzaro T, Condro MC, Kornblum HI, Seidlits SK. PMID: 36694362; PMCID: PMC10238626.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Interfer(on)ing with Zika virus. Neuron. 2022 12 07; 110(23):3853-3854. Alvarado AG, Kornblum HI. PMID: 36480937.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells. Nat Commun. 2022 10 19; 13(1):6202. Muthukrishnan SD, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, Wang Q, VanderVeer-Harris N, Pham A, Alvarado AG, Condro MC, Gao F, Gau R, Castro MG, Lowenstein PR, Deb A, Hinman JD, Pajonk F, Burns TC, Goldman SA, Geschwind DH, Kornblum HI. PMID: 36261421; PMCID: PMC9582000.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    19. A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration. Cell Rep. 2022 10 18; 41(3):111511. Ghochani Y, Muthukrishnan SD, Sohrabi A, Kawaguchi R, Condro MC, Bastola S, Gao F, Qin Y, Mottahedeh J, Iruela-Arispe ML, Rao N, Laks DR, Liau LM, Mathern GW, Goldman SA, Carmichael ST, Nakano I, Coppola G, Seidlits SK, Kornblum HI. PMID: 36261010; PMCID: PMC9642966.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    20. Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells. Nat Cell Biol. 2022 10; 24(10):1541-1557. Larionova TD, Bastola S, Aksinina TE, Anufrieva KS, Wang J, Shender VO, Andreev DE, Kovalenko TF, Arapidi GP, Shnaider PV, Kazakova AN, Latyshev YA, Tatarskiy VV, Shtil AA, Moreau P, Giraud F, Li C, Wang Y, Rubtsova MP, Dontsova OA, Condro M, Ellingson BM, Shakhparonov MI, Kornblum HI, Nakano I, Pavlyukov MS. PMID: 36192632; PMCID: PMC10026424.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    21. TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids. Stem Cell Reports. 2022 10 11; 17(10):2220-2238. Watanabe M, Buth JE, Haney JR, Vishlaghi N, Turcios F, Elahi LS, Gu W, Pearson CA, Kurdian A, Baliaouri NV, Collier AJ, Miranda OA, Dunn N, Chen D, Sabri S, Torre-Ubieta L, Clark AT, Plath K, Christofk HR, Kornblum HI, Gandal MJ, Novitch BG. PMID: 36179695; PMCID: PMC9561534.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    22. Pathway-based approach reveals differential sensitivity to E2F1 inhibition in glioblastoma. Cancer Res Commun. 2022 09; 2(9):1049-1060. Alvarado AG, Tessema K, Muthukrishnan SD, Sober M, Kawaguchi R, Laks DR, Bhaduri A, Swarup V, Nathanson DA, Geschwind DH, Goldman SA, Kornblum HI. PMID: 36213002; PMCID: PMC9536135.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma. Cancer Cell. 2022 09 12; 40(9):939-956.e16. Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG, McBrayer SK. PMID: 35985343; PMCID: PMC9515386.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    24. Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. Cell Rep. 2021 11 02; 37(5):109957. Bi J, Khan A, Tang J, Armando AM, Wu S, Zhang W, Gimple RC, Reed A, Jing H, Koga T, Wong IT, Gu Y, Miki S, Yang H, Prager B, Curtis EJ, Wainwright DA, Furnari FB, Rich JN, Cloughesy TF, Kornblum HI, Quehenberger O, Rzhetsky A, Cravatt BF, Mischel PS. PMID: 34731610; PMCID: PMC8856626.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    25. Dopamine Receptor Antagonists, Radiation, and Cholesterol Biosynthesis in Mouse Models of Glioblastoma. J Natl Cancer Inst. 2021 08 02; 113(8):1094-1104. Bhat K, Saki M, Cheng F, He L, Zhang L, Ioannidis A, Nathanson D, Tsang J, Bensinger SJ, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 33556960; PMCID: PMC8328983.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    26. Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. Nat Commun. 2021 06 25; 12(1):3958. Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y. PMID: 34172753; PMCID: PMC8233314.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    27. Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma. Radiother Oncol. 2021 08; 161:140-147. He L, Bhat K, Ioannidis A, Zhang L, Nguyen NT, Allen JE, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 34097975; PMCID: PMC8480533.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    28. High-Dimensional Analysis of Circulating and Tissue-Derived Myeloid-Derived Suppressor Cells from Patients with Glioblastoma. Methods Mol Biol. 2021; 2236:157-175. Alban TJ, Bayik D, Alvarado AG, Kornblum HI, Lathia JD. PMID: 33237547.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    29. Blended Phenotype of Silver-Russell Syndrome and SPG50 Caused by Maternal Isodisomy of Chromosome 7. Neurol Genet. 2021 Feb; 7(1):e544. Ziegler M, Russell BE, Eberhardt K, Geisel G, D'Amore A, Sahin M, Kornblum HI, Ebrahimi-Fakhari D. PMID: 33553621; PMCID: PMC7862086.
      View in: PubMed   Mentions: 6  
    30. Tumor edge-to-core transition promotes malignancy in primary-to-recurrent glioblastoma progression in a PLAGL1/CD109-mediated mechanism. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa163. Li C, Cho HJ, Yamashita D, Abdelrashid M, Chen Q, Bastola S, Chagoya G, Elsayed GA, Komarova S, Ozaki S, Ohtsuka Y, Kunieda T, Kornblum HI, Kondo T, Nam DH, Nakano I. PMID: 33392508; PMCID: PMC7764499.
      View in: PubMed   Mentions: 9  
    31. Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection. Stroke. 2021 01; 52(1):260-270. Kaneko N, Satta S, Komuro Y, Muthukrishnan SD, Kakarla V, Guo L, An J, Elahi F, Kornblum HI, Liebeskind DS, Hsiai T, Hinman JD. PMID: 33161843; PMCID: PMC7769899.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    32. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2020 11 02; 130(11):6187. Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 33044225; PMCID: PMC7598038.
      View in: PubMed   Mentions: 4     Fields:    
    33. Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma. J Hematol Oncol. 2020 10 21; 13(1):141. Lei K, Gu X, Alvarado AG, Du Y, Luo S, Ahn EH, Kang SS, Ji B, Liu X, Mao H, Fu H, Kornblum HI, Jin L, Li H, Ye K. PMID: 33087132; PMCID: PMC7579906.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    34. 1-[(4-Nitrophenyl)sulfonyl]-4-phenylpiperazine treatment after brain irradiation preserves cognitive function in mice. Neuro Oncol. 2020 10 14; 22(10):1484-1494. Bhat K, Medina P, He L, Zhang L, Saki M, Ioannidis A, Nguyen NT, Sodhi SS, Sung D, Magyar CE, Liau LM, Kornblum HI, Pajonk F. PMID: 32291451; PMCID: PMC7566405.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    35. Decorin expression is associated with predictive diffusion MR phenotypes of anti-VEGF efficacy in glioblastoma. Sci Rep. 2020 09 09; 10(1):14819. Patel KS, Yao J, Yao J, Raymond C, Yong W, Everson R, Liau LM, Nathanson D, Kornblum H, Wang C, Oughourlian T, Lai A, Nghiemphu PL, Pope WB, Cloughesy TF, Ellingson BM. PMID: 32908231; PMCID: PMC7481206.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    36. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2020 09 01; 130(9):5027. Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 32870163; PMCID: PMC7456217.
      View in: PubMed   Mentions:    Fields:    
    37. Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy. iScience. 2020 Sep 25; 23(9):101453. Sperry J, Condro MC, Guo L, Braas D, Vanderveer-Harris N, Kim KKO, Pope WB, Divakaruni AS, Lai A, Christofk H, Castro MG, Lowenstein PR, Le Belle JE, Kornblum HI. PMID: 32861192; PMCID: PMC7471621.
      View in: PubMed   Mentions: 38  
    38. Injectable diblock copolypeptide hydrogel provides platform to deliver effective concentrations of paclitaxel to an intracranial xenograft model of glioblastoma. PLoS One. 2020; 15(7):e0219632. Garrett MC, O'Shea TM, Wollenberg AL, Bernstein AM, Hung D, Staarman B, Soto H, Deming TJ, Sofroniew MV, Kornblum HI. PMID: 32706829; PMCID: PMC7380637.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    39. The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):11085-11096. Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 32358191; PMCID: PMC7245100.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    40. Targeting glioma-initiating cells via the tyrosine metabolic pathway. J Neurosurg. 2021 03 01; 134(3):721-732. Yamashita D, Bernstock JD, Elsayed G, Sadahiro H, Mohyeldin A, Chagoya G, Ilyas A, Mooney J, Estevez-Ordonez D, Yamaguchi S, Flanary VL, Hackney JR, Bhat KP, Kornblum HI, Zamboni N, Kim SH, Chiocca EA, Nakano I. PMID: 32059178; PMCID: PMC8447888.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    41. In memory of Jean de Vellis (1935-2018). J Neurodev Disord. 2019 12 16; 11(1):28. Bookheimer SY, Kornblum HI. PMID: 31839010; PMCID: PMC6912991.
      View in: PubMed   Mentions: 1     Fields:    
    42. Effects of Brain Irradiation in Immune-Competent and Immune-Compromised Mouse Models. Radiat Res. 2020 02; 193(2):186-194. Saki M, Bhat K, Sodhi SS, Nguyen NT, Kornblum HI, Pajonk F. PMID: 31774721; PMCID: PMC7135898.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    43. Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid-derived suppressor cells. JCI Insight. 2019 11 14; 4(22). Peereboom DM, Alban TJ, Grabowski MM, Alvarado AG, Otvos B, Bayik D, Roversi G, McGraw M, Huang P, Mohammadi AM, Kornblum HI, Radivoyevitch T, Ahluwalia MS, Vogelbaum MA, Lathia JD. PMID: 31600167; PMCID: PMC6948860.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCellsCTClinical Trials
    44. Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma. Neuro Oncol. 2019 08 05; 21(8):1016-1027. Greenall SA, McKenzie M, Seminova E, Dolezal O, Pearce L, Bentley J, Kuchibhotla M, Chen SC, McDonald KL, Kornblum HI, Endersby R, Adams TE, Johns TG. PMID: 31002307; PMCID: PMC6682217.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    45. Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab. 2019 09 03; 30(3):525-538.e8. Bi J, Ichu TA, Zanca C, Yang H, Zhang W, Gu Y, Chowdhry S, Reed A, Ikegami S, Turner KM, Zhang W, Villa GR, Wu S, Quehenberger O, Yong WH, Kornblum HI, Rich JN, Cloughesy TF, Cavenee WK, Furnari FB, Cravatt BF, Mischel PS. PMID: 31303424; PMCID: PMC6742496.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    46. SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation. J Neurooncol. 2019 May; 142(3):423-434. Liu F, Cox CD, Chowdhury R, Dovek L, Nguyen H, Li T, Li S, Ozer B, Chou A, Nguyen N, Wei B, Antonios J, Soto H, Kornblum H, Liau L, Prins R, Nghiemphu PL, Yong W, Cloughesy T, Lai A. PMID: 30838489; PMCID: PMC6516751.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    47. Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling. Cancer Res. 2019 03 15; 79(6):1085-1097. Chen AS, Wardwell-Ozgo J, Shah NN, Wright D, Appin CL, Vigneswaran K, Brat DJ, Kornblum HI, Read RD. PMID: 30530503; PMCID: PMC7339754.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    48. Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis. JCI Insight. 2018 11 02; 3(21). Alban TJ, Alvarado AG, Sorensen MD, Bayik D, Volovetz J, Serbinowski E, Mulkearns-Hubert EE, Sinyuk M, Hale JS, Onzi GR, McGraw M, Huang P, Grabowski MM, Wathen CA, Ahluwalia MS, Radivoyevitch T, Kornblum HI, Kristensen BW, Vogelbaum MA, Lathia JD. PMID: 30385717; PMCID: PMC6238746.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    49. A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma. Neuro Oncol. 2018 05 18; 20(6):764-775. Laks DR, Oses-Prieto JA, Alvarado AG, Nakashima J, Chand S, Azzam DB, Gholkar AA, Sperry J, Ludwig K, Condro MC, Nazarian S, Cardenas A, Shih MYS, Damoiseaux R, France B, Orozco N, Visnyei K, Crisman TJ, Gao F, Torres JZ, Coppola G, Burlingame AL, Kornblum HI. PMID: 29136244; PMCID: PMC5961175.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    50. Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities. Cancer Metab. 2018; 6:4. Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. PMID: 29692895; PMCID: PMC5905129.
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    51. Building Bonds: Cancer Stem Cells Depend on Their Progeny to Drive Tumor Progression. Cell Stem Cell. 2018 04 05; 22(4):473-474. Muthukrishnan SD, Alvarado AG, Kornblum HI. PMID: 29625062; PMCID: PMC8320684.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    52. D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation. Mol Cancer Res. 2018 06; 16(6):947-960. Li T, Cox CD, Ozer BH, Nguyen NT, Nguyen HN, Lai TJ, Li S, Liu F, Kornblum HI, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. PMID: 29545476; PMCID: PMC5984679.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    53. Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation. Oncotarget. 2017 Nov 28; 8(61):104007-104021. Senese S, Lo YC, Gholkar AA, Li CM, Huang Y, Mottahedeh J, Kornblum HI, Damoiseaux R, Torres JZ. PMID: 29262617; PMCID: PMC5732783.
      View in: PubMed   Mentions: 3     Fields:    
    54. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017 Nov; 23(11):1342-1351. Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA. PMID: 29035366; PMCID: PMC5683421.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    55. ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. Nat Commun. 2017 08 14; 8(1):241. Le TM, Poddar S, Capri JR, Abt ER, Kim W, Wei L, Uong NT, Cheng CM, Braas D, Nikanjam M, Rix P, Merkurjev D, Zaretsky J, Kornblum HI, Ribas A, Herschman HR, Whitelegge J, Faull KF, Donahue TR, Czernin J, Radu CG. PMID: 28808226; PMCID: PMC5556071.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    56. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2017 Aug 01; 127(8):3075-3089. Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 28737508; PMCID: PMC5531394.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    57. Molecular markers in glioma. J Neurooncol. 2017 Sep; 134(3):505-512. Ludwig K, Kornblum HI. PMID: 28233083; PMCID: PMC5568999.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimalsCells
    58. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237; PMCID: PMC5334176.
      View in: PubMed   Mentions: 332     Fields:    Translation:HumansCells
    59. Identification of an Efficient Gene Expression Panel for Glioblastoma Classification. PLoS One. 2016; 11(11):e0164649. Crisman TJ, Zelaya I, Laks DR, Zhao Y, Kawaguchi R, Gao F, Kornblum HI, Coppola G. PMID: 27855170; PMCID: PMC5113897.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    60. Large-scale assessment of the gliomasphere model system. Neuro Oncol. 2016 10; 18(10):1367-78. Laks DR, Crisman TJ, Shih MY, Mottahedeh J, Gao F, Sperry J, Garrett MC, Yong WH, Cloughesy TF, Liau LM, Lai A, Coppola G, Kornblum HI. PMID: 27116978; PMCID: PMC5035518.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    61. Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma. Mol Cancer Ther. 2016 06; 15(6):1271-8. Laks DR, Ta L, Crisman TJ, Gao F, Coppola G, Radu CG, Nathanson DA, Kornblum HI. PMID: 27196770; PMCID: PMC4893966.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    62. Neural Stem Cells (NSCs) and Proteomics. Mol Cell Proteomics. 2016 Feb; 15(2):344-54. Shoemaker LD, Kornblum HI. PMID: 26494823; PMCID: PMC4739658.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    63. MELK-a conserved kinase: functions, signaling, cancer, and controversy. Clin Transl Med. 2015; 4:11. Ganguly R, Mohyeldin A, Thiel J, Kornblum HI, Beullens M, Nakano I. PMID: 25852826; PMCID: PMC4385133.
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    64. Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells. Stem Cell Reports. 2014 Nov 11; 3(5):725-34. Le Belle JE, Sperry J, Ngo A, Ghochani Y, Laks DR, López-Aranda M, Silva AJ, Kornblum HI. PMID: 25418720; PMCID: PMC4235743.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    65. Maternal embryonic leucine zipper kinase: key kinase for stem cell phenotype in glioma and other cancers. Mol Cancer Ther. 2014 Jun; 13(6):1393-8. Ganguly R, Hong CS, Smith LG, Kornblum HI, Nakano I. PMID: 24795222; PMCID: PMC4048631.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    66. Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone. Stem Cell Res. 2014 Jul; 13(1):48-60. Thomsen GM, Le Belle JE, Harnisch JA, Mc Donald WS, Hovda DA, Sofroniew MV, Kornblum HI, Harris NG. PMID: 24835668; PMCID: PMC4096985.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    67. Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition. PLoS One. 2014; 9(4):e92546. Minata M, Gu C, Joshi K, Nakano-Okuno M, Hong C, Nguyen CH, Kornblum HI, Molla A, Nakano I. PMID: 24739874; PMCID: PMC3989164.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    68. Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors. Mol Cancer Res. 2014 May; 12(5):694-702. Panosyan EH, Wang Y, Xia P, Lee WN, Pak Y, Laks DR, Lin HJ, Moore TB, Cloughesy TF, Kornblum HI, Lasky JL. PMID: 24505127; PMCID: PMC4020976.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    69. Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation. Hum Mol Genet. 2014 Jul 01; 23(13):3481-9. Lee H, Lin MC, Kornblum HI, Papazian DM, Nelson SF. PMID: 24501278; PMCID: PMC4049306.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    70. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science. 2014 Jan 03; 343(6166):72-6. Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, Mischel PS. PMID: 24310612; PMCID: PMC4049335.
      View in: PubMed   Mentions: 307     Fields:    Translation:HumansAnimalsCells
    71. MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Stem Cells. 2013 Jun; 31(6):1051-63. Joshi K, Banasavadi-Siddegowda Y, Mo X, Kim SH, Mao P, Kig C, Nardini D, Sobol RW, Chow LM, Kornblum HI, Waclaw R, Beullens M, Nakano I. PMID: 23404835; PMCID: PMC3744761.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    72. De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discov. 2013 May; 3(5):534-47. Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS. PMID: 23533263; PMCID: PMC3651754.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    73. Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas. J Natl Cancer Inst. 2012 Oct 03; 104(19):1458-69. Chou AP, Chowdhury R, Li S, Chen W, Kim AJ, Piccioni DE, Selfridge JM, Mody RR, Chang S, Lalezari S, Lin J, Sanchez DE, Wilson RW, Garrett MC, Harry B, Mottahedeh J, Nghiemphu PL, Kornblum HI, Mischel PS, Prins RM, Yong WH, Cloughesy T, Nelson SF, Liau LM, Lai A. PMID: 22945948; PMCID: PMC3529615.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    74. Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. J Neurooncol. 2012 Mar; 107(1):197-205. Pope WB, Prins RM, Albert Thomas M, Nagarajan R, Yen KE, Bittinger MA, Salamon N, Chou AP, Yong WH, Soto H, Wilson N, Driggers E, Jang HG, Su SM, Schenkein DP, Lai A, Cloughesy TF, Kornblum HI, Wu H, Fantin VR, Liau LM. PMID: 22015945; PMCID: PMC3650613.
      View in: PubMed   Mentions: 149     Fields:    Translation:Humans
    75. Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells. Mol Cancer Res. 2011 Dec; 9(12):1668-85. Liu Y, Ye F, Yamada K, Tso JL, Zhang Y, Nguyen DH, Dong Q, Soto H, Choe J, Dembo A, Wheeler H, Eskin A, Schmid I, Yong WH, Mischel PS, Cloughesy TF, Kornblum HI, Nelson SF, Liau LM, Tso CL. PMID: 22013079; PMCID: PMC3245317.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    76. CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway. PLoS One. 2011; 6(9):e24217. Jijiwa M, Demir H, Gupta S, Leung C, Joshi K, Orozco N, Huang T, Yildiz VO, Shibahara I, de Jesus JA, Yong WH, Mischel PS, Fernandez S, Kornblum HI, Nakano I. PMID: 21915300; PMCID: PMC3167830.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    77. A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. Mol Cancer Ther. 2011 Oct; 10(10):1818-28. Visnyei K, Onodera H, Damoiseaux R, Saigusa K, Petrosyan S, De Vries D, Ferrari D, Saxe J, Panosyan EH, Masterman-Smith M, Mottahedeh J, Bradley KA, Huang J, Sabatti C, Nakano I, Kornblum HI. PMID: 21859839; PMCID: PMC3191241.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    78. Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. Neuro Oncol. 2011 Jun; 13(6):622-34. Nakano I, Joshi K, Visnyei K, Hu B, Watanabe M, Lam D, Wexler E, Saigusa K, Nakamura Y, Laks DR, Mischel PS, Viapiano M, Kornblum HI. PMID: 21558073; PMCID: PMC3107094.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    79. Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner. Cell Stem Cell. 2011 Jan 07; 8(1):59-71. Le Belle JE, Orozco NM, Paucar AA, Saxe JP, Mottahedeh J, Pyle AD, Wu H, Kornblum HI. PMID: 21211782; PMCID: PMC3018289.
      View in: PubMed   Mentions: 374     Fields:    Translation:HumansAnimalsCells
    80. MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states. Cell Stem Cell. 2010 Dec 03; 7(6):671-81. Neveu P, Kye MJ, Qi S, Buchholz DE, Clegg DO, Sahin M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS. PMID: 21112562.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    81. Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi-passageable neurosphere formation. Pediatr Blood Cancer. 2010 Oct; 55(4):644-51. Panosyan EH, Laks DR, Masterman-Smith M, Mottahedeh J, Yong WH, Cloughesy TF, Lazareff JA, Mischel PS, Moore TB, Kornblum HI. PMID: 20589659; PMCID: PMC4017922.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    82. Brain tumor stem cells as therapeutic targets in models of glioma. Yonsei Med J. 2010 Sep; 51(5):633-40. Laks DR, Visnyei K, Kornblum HI. PMID: 20635435; PMCID: PMC2908869.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    83. A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer Res. 2010 Aug 01; 70(15):6128-38. Sun J, Masterman-Smith MD, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, DeJesus J, Kamei K, Lee KB, Wang H, Yu ZT, Lu YT, Hou S, Li K, Liu M, Zhang N, Wang S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathanson D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI, Yong WH, Graeber TG, Tseng HR. PMID: 20631065; PMCID: PMC3163840.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    84. A multipronged approach to the identification and study of an important oncogene in GBM. Cancer Cell. 2010 May 18; 17(5):417-8. Kornblum HI. PMID: 20478522.
      View in: PubMed   Mentions: 1     Fields:    
    85. Hydrogel matrix to support stem cell survival after brain transplantation in stroke. Neurorehabil Neural Repair. 2010 Sep; 24(7):636-44. Zhong J, Chan A, Morad L, Kornblum HI, Fan G, Carmichael ST. PMID: 20424193; PMCID: PMC4697440.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    86. Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors. PLoS One. 2010 Feb 09; 5(2):e9121. Shoemaker LD, Orozco NM, Geschwind DH, Whitelegge JP, Faull KF, Kornblum HI. PMID: 20161753; PMCID: PMC2817745.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    87. Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. J Neurochem. 2009 Oct; 111(2):332-43. Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A. PMID: 19694903.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    88. Endogenous Wnt signaling maintains neural progenitor cell potency. Stem Cells. 2009 May; 27(5):1130-41. Wexler EM, Paucer A, Kornblum HI, Palmer TD, Plamer TD, Geschwind DH. PMID: 19418460; PMCID: PMC2782960.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    89. Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem Cells. 2009 Apr; 27(4):980-7. Laks DR, Masterman-Smith M, Visnyei K, Angenieux B, Orozco NM, Foran I, Yong WH, Vinters HV, Liau LM, Lazareff JA, Mischel PS, Cloughesy TF, Horvath S, Kornblum HI. PMID: 19353526; PMCID: PMC3177534.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    90. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells. 2009 Apr; 27(4):806-11. Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE. PMID: 19350680; PMCID: PMC2895909.
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    91. Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS. Dis Model Mech. 2009 Mar-Apr; 2(3-4):189-95. Karumbayaram S, Kelly TK, Paucar AA, Roe AJ, Umbach JA, Charles A, Goldman SA, Kornblum HI, Wiedau-Pazos M. PMID: 19259395; PMCID: PMC2650191.
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    92. Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci. 2009 Feb 11; 29(6):1874-86. Gregorian C, Nakashima J, Le Belle J, Ohab J, Kim R, Liu A, Smith KB, Groszer M, Garcia AD, Sofroniew MV, Carmichael ST, Kornblum HI, Liu X, Wu H. PMID: 19211894; PMCID: PMC2754186.
      View in: PubMed   Mentions: 151     Fields:    Translation:AnimalsCells
    93. Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cells. PLoS One. 2009; 4(1):e4213. Kelly TK, Karsten SL, Geschwind DH, Kornblum HI. PMID: 19148290; PMCID: PMC2615219.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    94. Methods for analysis of brain tumor stem cell and neural stem cell self-renewal. Methods Mol Biol. 2009; 568:37-56. Nakano I, Kornblum HI. PMID: 19582420.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    95. Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Ann N Y Acad Sci. 2008 Dec; 1147:383-94. Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, Gazaryan I. PMID: 19076458; PMCID: PMC2921907.
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    96. Roles of insulin and transferrin in neural progenitor survival and proliferation. J Neurosci Res. 2008 Jun; 86(8):1884-94. Erickson RI, Paucar AA, Jackson RL, Visnyei K, Kornblum H. PMID: 18293414.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    97. BMPing off glioma stem cells. Cancer Cell. 2008 Jan; 13(1):3-4. Nakano I, Saigusa K, Kornblum HI. PMID: 18167333.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    98. Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. J Neurosci Res. 2008 Jan; 86(1):48-60. Nakano I, Masterman-Smith M, Saigusa K, Paucar AA, Horvath S, Shoemaker L, Watanabe M, Negro A, Bajpai R, Howes A, Lelievre V, Waschek JA, Lazareff JA, Freije WA, Liau LM, Gilbertson RJ, Cloughesy TF, Geschwind DH, Nelson SF, Mischel PS, Terskikh AV, Kornblum HI. PMID: 17722061.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    99. Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice. Dev Biol. 2008 Jan 01; 313(1):359-70. Lelievre V, Seksenyan A, Nobuta H, Yong WH, Chhith S, Niewiadomski P, Cohen JR, Dong H, Flores A, Liau LM, Kornblum HI, Scott MP, Waschek JA. PMID: 18036580; PMCID: PMC2206628.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    100. A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem Biol. 2007 Sep; 14(9):1019-30. Saxe JP, Wu H, Kelly TK, Phelps ME, Sun YE, Kornblum HI, Huang J. PMID: 17884634; PMCID: PMC2758915.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    101. Detection of a microRNA signal in an in vivo expression set of mRNAs. PLoS One. 2007 Aug 29; 2(8):e804. Liu T, Papagiannakopoulos T, Puskar K, Qi S, Santiago F, Clay W, Lao K, Lee Y, Nelson SF, Kornblum HI, Doyle F, Petzold L, Shraiman B, Kosik KS. PMID: 17726534; PMCID: PMC1950084.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    102. Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Stem Cells. 2007 Aug; 25(8):1975-84. Nakano I, Dougherty JD, Kim K, Klement I, Geschwind DH, Kornblum HI. PMID: 17495110.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    103. Introduction to neural stem cells. Stroke. 2007 Feb; 38(2 Suppl):810-6. Kornblum HI. PMID: 17261745.
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    104. Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006. Stem Cells. 2007 Apr; 25(4):1070-88. Cheng JC, Horwitz EM, Karsten SL, Shoemaker L, Kornblum HI, Malik P, Sakamoto KM. PMID: 17255523.
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    105. Brain tumor stem cells. Pediatr Res. 2006 Apr; 59(4 Pt 2):54R-8R. Nakano I, Kornblum HI. PMID: 16549549.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    106. Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes. Glia. 2006 Feb; 53(3):277-93. Imura T, Nakano I, Kornblum HI, Sofroniew MV. PMID: 16267834.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    107. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006 Jan 03; 103(1):111-6. Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H. PMID: 16373498; PMCID: PMC1325011.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    108. Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion. Exp Neurol. 2006 Feb; 197(2):465-74. Visnyei K, Tatsukawa KJ, Erickson RI, Simonian S, Oknaian N, Carmichael ST, Kornblum HI. PMID: 16310773.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    109. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol. 2005 Aug 01; 170(3):413-27. Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI. PMID: 16061694; PMCID: PMC2171475.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    110. Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions. J Neurosci Res. 2005 Mar 01; 79(5):584-97. Fox IJ, Kornblum HI. PMID: 15682390.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    111. Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones--implications for stem cell biology. Brain Res Dev Brain Res. 2004 Oct 15; 153(1):121-5. Fox IJ, Paucar AA, Nakano I, Mottahedeh J, Dougherty JD, Kornblum HI. PMID: 15464225.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    112. [Cancer stem cells in pediatric brain tumors]. No Shinkei Geka. 2004 Aug; 32(8):827-34. Nakano I, Hemmati HD, Kornblum HI. PMID: 15478649.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    113. Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily. J Neurosci Res. 2004 Jul 15; 77(2):166-73. Tiwari-Woodruff SK, Kaplan R, Kornblum HI, Bronstein JM. PMID: 15211584.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    114. Metabolic correlates of lesion-specific plasticity: an in vivo imaging study. Brain Res. 2004 Mar 26; 1002(1-2):28-34. Mir HM, Tatsukawa KJ, Carmichael ST, Chesselet MF, Kornblum HI. PMID: 14988030.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    115. Evolution of diaschisis in a focal stroke model. Stroke. 2004 Mar; 35(3):758-63. Carmichael ST, Tatsukawa K, Katsman D, Tsuyuguchi N, Kornblum HI. PMID: 14963280.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    116. Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells. J Neurosci Res. 2004 Feb 01; 75(3):330-43. Irvin DK, Nakano I, Paucar A, Kornblum HI. PMID: 14743446.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    117. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Dev Biol. 2003 Dec 15; 264(2):309-22. Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI. PMID: 14651920.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    118. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15178-83. Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI. PMID: 14645703; PMCID: PMC299944.
      View in: PubMed   Mentions: 761     Fields:    Translation:HumansAnimalsCells
    119. Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks. Dev Biol. 2003 Sep 01; 261(1):165-82. Karsten SL, Kudo LC, Jackson R, Sabatti C, Kornblum HI, Geschwind DH. PMID: 12941627.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    120. Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain. J Comp Neurol. 2003 Jul 21; 462(2):265-73. Fu L, Abu-Khalil A, Morrison RS, Geschwind DH, Kornblum HI. PMID: 12794748.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    121. The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP. J Neurosci. 2003 Apr 01; 23(7):2824-32. Imura T, Kornblum HI, Sofroniew MV. PMID: 12684469; PMCID: PMC6742109.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    122. Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures. Dev Neurosci. 2003 Mar-Aug; 25(2-4):162-72. Irvin DK, Dhaka A, Hicks C, Weinmaster G, Kornblum HI. PMID: 12966214.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    123. The RAS effector RIN1 modulates the formation of aversive memories. J Neurosci. 2003 Feb 01; 23(3):748-57. Dhaka A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J. PMID: 12574403; PMCID: PMC6741936.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    124. Social communication in children with epilepsy. J Child Psychol Psychiatry. 2002 Feb; 43(2):245-53. Caplan R, Guthrie D, Komo S, Siddarth P, Chayasirisobhon S, Kornblum H, Sankar R, Hansen R, Mitchell W, Shields WD. PMID: 11902603.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    125. Comparison of thalamic populations in mammals and birds: expression of ErbB4 mRNA. Brain Res Bull. 2002 Feb-Mar 1; 57(3-4):455-61. Bruce LL, Kornblum HI, Seroogy KB. PMID: 11923010.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    126. Molecular markers in CNS stem cell research: hitting a moving target. Nat Rev Neurosci. 2001 Nov; 2(11):843-6. Kornblum HI, Geschwind DH. PMID: 11715062.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    127. In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET). Nat Biotechnol. 2000 Jun; 18(6):655-60. Kornblum HI, Araujo DM, Annala AJ, Tatsukawa KJ, Phelps ME, Cherry SR. PMID: 10835605.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
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