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Valproic acid targets IDH1 mutants through alteration of lipid metabolism. NPJ Metab Health Dis. 2024; 2(1):20.
Elahi LS, Condro MC, Kawaguchi R, Qin Y, Alvarado AG, Gruender B, Qi H, Li T, Lai A, Castro MG, Lowenstein PR, Garrett MC, Kornblum HI. PMID: 39149696; PMCID: PMC11321993.
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PubMed Mentions:
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Valproic acid targets IDH1 mutants through alteration of lipid metabolism. NPJ Metab Health Dis. 2024; 2(1):20.
Elahi LS, Condro MC, Kawaguchi R, Qin Y, Alvarado AG, Gruender B, Qi H, Li T, Lai A, Castro MG, Lowenstein PR, Garrett MC, Kornblum HI. PMID: 39149696; PMCID: PMC11321993.
View in:
PubMed Mentions:
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Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth. Mol Cancer Res. 2024 07 02; 22(7):656-667.
Muthukrishnan SD, Qi H, Wang D, Elahi L, Pham A, Alvarado AG, Li T, Gao F, Kawaguchi R, Lai A, Kornblum HI. PMID: 38441553; PMCID: PMC11217726.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1. Cancer Res Commun. 2024 Jun 25; 4(6):1566-1580.
He L, Ioannidis A, Hoffman CJ, Arambula E, Joshi P, Whitelegge J, Liau LM, Kornblum HI, Pajonk F. PMID: 38837899; PMCID: PMC11197925.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Radiation-Induced Cellular Plasticity: A Strategy for Combatting Glioblastoma. bioRxiv. 2024 May 16.
He L, Azizad D, Bhat K, Ioannidis A, Hoffmann CJ, Arambula E, Bhaduri A, Kornblum HI, Pajonk F. PMID: 38798647; PMCID: PMC11118449.
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PubMed Mentions:
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D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation. Cancer Res Commun. 2024 Mar 22; 4(3):876-894.
Pianka ST, Li T, Prins TJ, Eldred BSC, Kevan BM, Liang H, Zapanta Rinonos S, Kornblum HI, Nathanson DA, Pellegrini M, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. PMID: 38445960; PMCID: PMC10959073.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Single-nucleus expression characterization of non-enhancing region of recurrent high-grade glioma. Neurooncol Adv. 2024 Jan-Dec; 6(1):vdae005.
Patel KS, Tessema KK, Kawaguchi R, Dudley L, Alvarado AG, Muthukrishnan SD, Perryman T, Hagiwara A, Swarup V, Liau LM, Wang AC, Yong W, Geschwind DH, Nakano I, Goldman SA, Everson RG, Ellingson BM, Kornblum HI. PMID: 38616896; PMCID: PMC11012612.
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PubMed Mentions:
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pH-Weighted amine chemical exchange saturation transfer echo planar imaging visualizes infiltrating glioblastoma cells. Neuro Oncol. 2024 01 05; 26(1):115-126.
Patel KS, Yao J, Cho NS, Sanvito F, Tessema K, Alvarado A, Dudley L, Rodriguez F, Everson R, Cloughesy TF, Salamon N, Liau LM, Kornblum HI, Ellingson BM. PMID: 37591790; PMCID: PMC10768991.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance. Neuro Oncol. 2023 11 02; 25(11):1989-2000.
Bailleul J, Ruan Y, Abdulrahman L, Scott AJ, Yazal T, Sung D, Park K, Hoang H, Nathaniel J, Chu FI, Palomera D, Sehgal A, Tsang JE, Nathanson DA, Xu S, Park JO, Ten Hoeve J, Bhat K, Qi N, Kornblum HI, Schaue D, McBride WH, Lyssiotis CA, Wahl DR, Vlashi E. PMID: 37279645; PMCID: PMC10628945.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Nicotinamide Adenine Dinucleotide Phosphate Oxidase Promotes Glioblastoma Radiation Resistance in a Phosphate and Tensin Homolog-Dependent Manner. Antioxid Redox Signal. 2023 11; 39(13-15):890-903.
Ludwig K, Le Belle JE, Muthukrishnan SD, Sperry J, Condro M, Vlashi E, Pajonk F, Kornblum HI. PMID: 37470216; PMCID: PMC10775910.
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PubMed Mentions:
2 Fields:
Translation:
Humans
-
Microenvironmental stiffness induces metabolic reprogramming in glioblastoma. Cell Rep. 2023 10 31; 42(10):113175.
Sohrabi A, Lefebvre AEYT, Harrison MJ, Condro MC, Sanazzaro TM, Safarians G, Solomon I, Bastola S, Kordbacheh S, Toh N, Kornblum HI, Digman MA, Seidlits SK. PMID: 37756163; PMCID: PMC10842372.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Sci Rep. 2023 08 01; 13(1):12433.
Garrett MC, Albano R, Carnwath T, Elahi L, Behrmann CA, Pemberton M, Woo D, O'Brien E, VanCauwenbergh B, Perentesis J, Shah S, Hagan M, Kendler A, Zhao C, Paranjpe A, Roskin K, Kornblum H, Plas DR, Lu QR. PMID: 37528157; PMCID: PMC10394035.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1. bioRxiv. 2023 Jul 25.
He L, Ioannidis A, Arambula E, Hoffman CJ, Joshi P, Kathiravan A, Whitelegge J, Liau LM, Kornblum HI, Pajonk F. PMID: 37546917; PMCID: PMC10402033.
View in:
PubMed Mentions:
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Low- and high-grade glioma endothelial cells differentially regulate tumor growth. bioRxiv. 2023 Jul 07.
Muthukrishnan SD, Qi H, Wang D, Elahi L, Pham A, Alvarado AG, Li T, Gao F, Kawaguchi R, Lai A, Kornblum HI. PMID: 37461434; PMCID: PMC10350040.
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PubMed Mentions:
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(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers. Cancer Discov. 2023 06 02; 13(6):1478-1497.
Gunn K, Myllykoski M, Cao JZ, Ahmed M, Huang B, Rouaisnel B, Diplas BH, Levitt MM, Looper R, Doench JG, Ligon KL, Kornblum HI, McBrayer SK, Yan H, Duy C, Godley LA, Koivunen P, Losman JA. PMID: 36847506; PMCID: PMC10238656.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Glioblastoma Spheroid Invasion through Soft, Brain-Like Matrices Depends on Hyaluronic Acid-CD44 Interactions. Adv Healthc Mater. 2023 06; 12(14):e2203143.
Safarians G, Sohrabi A, Solomon I, Xiao W, Bastola S, Rajput BW, Epperson M, Rosenzweig I, Tamura K, Singer B, Huang J, Harrison MJ, Sanazzaro T, Condro MC, Kornblum HI, Seidlits SK. PMID: 36694362; PMCID: PMC10238626.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Interfer(on)ing with Zika virus. Neuron. 2022 12 07; 110(23):3853-3854.
Alvarado AG, Kornblum HI. PMID: 36480937.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells. Nat Commun. 2022 10 19; 13(1):6202.
Muthukrishnan SD, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, Wang Q, VanderVeer-Harris N, Pham A, Alvarado AG, Condro MC, Gao F, Gau R, Castro MG, Lowenstein PR, Deb A, Hinman JD, Pajonk F, Burns TC, Goldman SA, Geschwind DH, Kornblum HI. PMID: 36261421; PMCID: PMC9582000.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration. Cell Rep. 2022 10 18; 41(3):111511.
Ghochani Y, Muthukrishnan SD, Sohrabi A, Kawaguchi R, Condro MC, Bastola S, Gao F, Qin Y, Mottahedeh J, Iruela-Arispe ML, Rao N, Laks DR, Liau LM, Mathern GW, Goldman SA, Carmichael ST, Nakano I, Coppola G, Seidlits SK, Kornblum HI. PMID: 36261010; PMCID: PMC9642966.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells. Nat Cell Biol. 2022 10; 24(10):1541-1557.
Larionova TD, Bastola S, Aksinina TE, Anufrieva KS, Wang J, Shender VO, Andreev DE, Kovalenko TF, Arapidi GP, Shnaider PV, Kazakova AN, Latyshev YA, Tatarskiy VV, Shtil AA, Moreau P, Giraud F, Li C, Wang Y, Rubtsova MP, Dontsova OA, Condro M, Ellingson BM, Shakhparonov MI, Kornblum HI, Nakano I, Pavlyukov MS. PMID: 36192632; PMCID: PMC10026424.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids. Stem Cell Reports. 2022 10 11; 17(10):2220-2238.
Watanabe M, Buth JE, Haney JR, Vishlaghi N, Turcios F, Elahi LS, Gu W, Pearson CA, Kurdian A, Baliaouri NV, Collier AJ, Miranda OA, Dunn N, Chen D, Sabri S, Torre-Ubieta L, Clark AT, Plath K, Christofk HR, Kornblum HI, Gandal MJ, Novitch BG. PMID: 36179695; PMCID: PMC9561534.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Pathway-based approach reveals differential sensitivity to E2F1 inhibition in glioblastoma. Cancer Res Commun. 2022 09; 2(9):1049-1060.
Alvarado AG, Tessema K, Muthukrishnan SD, Sober M, Kawaguchi R, Laks DR, Bhaduri A, Swarup V, Nathanson DA, Geschwind DH, Goldman SA, Kornblum HI. PMID: 36213002; PMCID: PMC9536135.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma. Cancer Cell. 2022 09 12; 40(9):939-956.e16.
Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG, McBrayer SK. PMID: 35985343; PMCID: PMC9515386.
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PubMed Mentions:
35 Fields:
Translation:
Animals
-
Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. Cell Rep. 2021 11 02; 37(5):109957.
Bi J, Khan A, Tang J, Armando AM, Wu S, Zhang W, Gimple RC, Reed A, Jing H, Koga T, Wong IT, Gu Y, Miki S, Yang H, Prager B, Curtis EJ, Wainwright DA, Furnari FB, Rich JN, Cloughesy TF, Kornblum HI, Quehenberger O, Rzhetsky A, Cravatt BF, Mischel PS. PMID: 34731610; PMCID: PMC8856626.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Dopamine Receptor Antagonists, Radiation, and Cholesterol Biosynthesis in Mouse Models of Glioblastoma. J Natl Cancer Inst. 2021 08 02; 113(8):1094-1104.
Bhat K, Saki M, Cheng F, He L, Zhang L, Ioannidis A, Nathanson D, Tsang J, Bensinger SJ, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 33556960; PMCID: PMC8328983.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. Nat Commun. 2021 06 25; 12(1):3958.
Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y. PMID: 34172753; PMCID: PMC8233314.
View in:
PubMed Mentions:
77 Fields:
Translation:
HumansAnimalsCells
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Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma. Radiother Oncol. 2021 08; 161:140-147.
He L, Bhat K, Ioannidis A, Zhang L, Nguyen NT, Allen JE, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 34097975; PMCID: PMC8480533.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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High-Dimensional Analysis of Circulating and Tissue-Derived Myeloid-Derived Suppressor Cells from Patients with Glioblastoma. Methods Mol Biol. 2021; 2236:157-175.
Alban TJ, Bayik D, Alvarado AG, Kornblum HI, Lathia JD. PMID: 33237547.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Blended Phenotype of Silver-Russell Syndrome and SPG50 Caused by Maternal Isodisomy of Chromosome 7. Neurol Genet. 2021 Feb; 7(1):e544.
Ziegler M, Russell BE, Eberhardt K, Geisel G, D'Amore A, Sahin M, Kornblum HI, Ebrahimi-Fakhari D. PMID: 33553621; PMCID: PMC7862086.
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PubMed Mentions:
6
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Tumor edge-to-core transition promotes malignancy in primary-to-recurrent glioblastoma progression in a PLAGL1/CD109-mediated mechanism. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa163.
Li C, Cho HJ, Yamashita D, Abdelrashid M, Chen Q, Bastola S, Chagoya G, Elsayed GA, Komarova S, Ozaki S, Ohtsuka Y, Kunieda T, Kornblum HI, Kondo T, Nam DH, Nakano I. PMID: 33392508; PMCID: PMC7764499.
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PubMed Mentions:
9
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Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection. Stroke. 2021 01; 52(1):260-270.
Kaneko N, Satta S, Komuro Y, Muthukrishnan SD, Kakarla V, Guo L, An J, Elahi F, Kornblum HI, Liebeskind DS, Hsiai T, Hinman JD. PMID: 33161843; PMCID: PMC7769899.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2020 11 02; 130(11):6187.
Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 33044225; PMCID: PMC7598038.
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PubMed Mentions:
4 Fields:
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Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma. J Hematol Oncol. 2020 10 21; 13(1):141.
Lei K, Gu X, Alvarado AG, Du Y, Luo S, Ahn EH, Kang SS, Ji B, Liu X, Mao H, Fu H, Kornblum HI, Jin L, Li H, Ye K. PMID: 33087132; PMCID: PMC7579906.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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1-[(4-Nitrophenyl)sulfonyl]-4-phenylpiperazine treatment after brain irradiation preserves cognitive function in mice. Neuro Oncol. 2020 10 14; 22(10):1484-1494.
Bhat K, Medina P, He L, Zhang L, Saki M, Ioannidis A, Nguyen NT, Sodhi SS, Sung D, Magyar CE, Liau LM, Kornblum HI, Pajonk F. PMID: 32291451; PMCID: PMC7566405.
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PubMed Mentions:
4 Fields:
Translation:
Animals
-
Decorin expression is associated with predictive diffusion MR phenotypes of anti-VEGF efficacy in glioblastoma. Sci Rep. 2020 09 09; 10(1):14819.
Patel KS, Yao J, Yao J, Raymond C, Yong W, Everson R, Liau LM, Nathanson D, Kornblum H, Wang C, Oughourlian T, Lai A, Nghiemphu PL, Pope WB, Cloughesy TF, Ellingson BM. PMID: 32908231; PMCID: PMC7481206.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2020 09 01; 130(9):5027.
Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 32870163; PMCID: PMC7456217.
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PubMed Mentions: Fields:
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Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy. iScience. 2020 Sep 25; 23(9):101453.
Sperry J, Condro MC, Guo L, Braas D, Vanderveer-Harris N, Kim KKO, Pope WB, Divakaruni AS, Lai A, Christofk H, Castro MG, Lowenstein PR, Le Belle JE, Kornblum HI. PMID: 32861192; PMCID: PMC7471621.
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PubMed Mentions:
38
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Injectable diblock copolypeptide hydrogel provides platform to deliver effective concentrations of paclitaxel to an intracranial xenograft model of glioblastoma. PLoS One. 2020; 15(7):e0219632.
Garrett MC, O'Shea TM, Wollenberg AL, Bernstein AM, Hung D, Staarman B, Soto H, Deming TJ, Sofroniew MV, Kornblum HI. PMID: 32706829; PMCID: PMC7380637.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):11085-11096.
Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 32358191; PMCID: PMC7245100.
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PubMed Mentions:
22 Fields:
Translation:
Animals
-
Targeting glioma-initiating cells via the tyrosine metabolic pathway. J Neurosurg. 2021 03 01; 134(3):721-732.
Yamashita D, Bernstock JD, Elsayed G, Sadahiro H, Mohyeldin A, Chagoya G, Ilyas A, Mooney J, Estevez-Ordonez D, Yamaguchi S, Flanary VL, Hackney JR, Bhat KP, Kornblum HI, Zamboni N, Kim SH, Chiocca EA, Nakano I. PMID: 32059178; PMCID: PMC8447888.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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In memory of Jean de Vellis (1935-2018). J Neurodev Disord. 2019 12 16; 11(1):28.
Bookheimer SY, Kornblum HI. PMID: 31839010; PMCID: PMC6912991.
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PubMed Mentions:
1 Fields:
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Effects of Brain Irradiation in Immune-Competent and Immune-Compromised Mouse Models. Radiat Res. 2020 02; 193(2):186-194.
Saki M, Bhat K, Sodhi SS, Nguyen NT, Kornblum HI, Pajonk F. PMID: 31774721; PMCID: PMC7135898.
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PubMed Mentions:
2 Fields:
Translation:
Animals
-
Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid-derived suppressor cells. JCI Insight. 2019 11 14; 4(22).
Peereboom DM, Alban TJ, Grabowski MM, Alvarado AG, Otvos B, Bayik D, Roversi G, McGraw M, Huang P, Mohammadi AM, Kornblum HI, Radivoyevitch T, Ahluwalia MS, Vogelbaum MA, Lathia JD. PMID: 31600167; PMCID: PMC6948860.
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PubMed Mentions:
58 Fields:
Translation:
HumansCellsCTClinical Trials
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Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma. Neuro Oncol. 2019 08 05; 21(8):1016-1027.
Greenall SA, McKenzie M, Seminova E, Dolezal O, Pearce L, Bentley J, Kuchibhotla M, Chen SC, McDonald KL, Kornblum HI, Endersby R, Adams TE, Johns TG. PMID: 31002307; PMCID: PMC6682217.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab. 2019 09 03; 30(3):525-538.e8.
Bi J, Ichu TA, Zanca C, Yang H, Zhang W, Gu Y, Chowdhry S, Reed A, Ikegami S, Turner KM, Zhang W, Villa GR, Wu S, Quehenberger O, Yong WH, Kornblum HI, Rich JN, Cloughesy TF, Cavenee WK, Furnari FB, Cravatt BF, Mischel PS. PMID: 31303424; PMCID: PMC6742496.
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PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
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SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation. J Neurooncol. 2019 May; 142(3):423-434.
Liu F, Cox CD, Chowdhury R, Dovek L, Nguyen H, Li T, Li S, Ozer B, Chou A, Nguyen N, Wei B, Antonios J, Soto H, Kornblum H, Liau L, Prins R, Nghiemphu PL, Yong W, Cloughesy T, Lai A. PMID: 30838489; PMCID: PMC6516751.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling. Cancer Res. 2019 03 15; 79(6):1085-1097.
Chen AS, Wardwell-Ozgo J, Shah NN, Wright D, Appin CL, Vigneswaran K, Brat DJ, Kornblum HI, Read RD. PMID: 30530503; PMCID: PMC7339754.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis. JCI Insight. 2018 11 02; 3(21).
Alban TJ, Alvarado AG, Sorensen MD, Bayik D, Volovetz J, Serbinowski E, Mulkearns-Hubert EE, Sinyuk M, Hale JS, Onzi GR, McGraw M, Huang P, Grabowski MM, Wathen CA, Ahluwalia MS, Radivoyevitch T, Kornblum HI, Kristensen BW, Vogelbaum MA, Lathia JD. PMID: 30385717; PMCID: PMC6238746.
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PubMed Mentions:
106 Fields:
Translation:
HumansCells
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A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma. Neuro Oncol. 2018 05 18; 20(6):764-775.
Laks DR, Oses-Prieto JA, Alvarado AG, Nakashima J, Chand S, Azzam DB, Gholkar AA, Sperry J, Ludwig K, Condro MC, Nazarian S, Cardenas A, Shih MYS, Damoiseaux R, France B, Orozco N, Visnyei K, Crisman TJ, Gao F, Torres JZ, Coppola G, Burlingame AL, Kornblum HI. PMID: 29136244; PMCID: PMC5961175.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities. Cancer Metab. 2018; 6:4.
Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. PMID: 29692895; PMCID: PMC5905129.
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PubMed Mentions:
35
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Building Bonds: Cancer Stem Cells Depend on Their Progeny to Drive Tumor Progression. Cell Stem Cell. 2018 04 05; 22(4):473-474.
Muthukrishnan SD, Alvarado AG, Kornblum HI. PMID: 29625062; PMCID: PMC8320684.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation. Mol Cancer Res. 2018 06; 16(6):947-960.
Li T, Cox CD, Ozer BH, Nguyen NT, Nguyen HN, Lai TJ, Li S, Liu F, Kornblum HI, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. PMID: 29545476; PMCID: PMC5984679.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation. Oncotarget. 2017 Nov 28; 8(61):104007-104021.
Senese S, Lo YC, Gholkar AA, Li CM, Huang Y, Mottahedeh J, Kornblum HI, Damoiseaux R, Torres JZ. PMID: 29262617; PMCID: PMC5732783.
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PubMed Mentions:
3 Fields:
-
Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017 Nov; 23(11):1342-1351.
Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA. PMID: 29035366; PMCID: PMC5683421.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. Nat Commun. 2017 08 14; 8(1):241.
Le TM, Poddar S, Capri JR, Abt ER, Kim W, Wei L, Uong NT, Cheng CM, Braas D, Nikanjam M, Rix P, Merkurjev D, Zaretsky J, Kornblum HI, Ribas A, Herschman HR, Whitelegge J, Faull KF, Donahue TR, Czernin J, Radu CG. PMID: 28808226; PMCID: PMC5556071.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2017 Aug 01; 127(8):3075-3089.
Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I. PMID: 28737508; PMCID: PMC5531394.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Molecular markers in glioma. J Neurooncol. 2017 Sep; 134(3):505-512.
Ludwig K, Kornblum HI. PMID: 28233083; PMCID: PMC5568999.
View in:
PubMed Mentions:
186 Fields:
Translation:
HumansAnimalsCells
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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125.
Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237; PMCID: PMC5334176.
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PubMed Mentions:
345 Fields:
Translation:
HumansCells
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Identification of an Efficient Gene Expression Panel for Glioblastoma Classification. PLoS One. 2016; 11(11):e0164649.
Crisman TJ, Zelaya I, Laks DR, Zhao Y, Kawaguchi R, Gao F, Kornblum HI, Coppola G. PMID: 27855170; PMCID: PMC5113897.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Large-scale assessment of the gliomasphere model system. Neuro Oncol. 2016 10; 18(10):1367-78.
Laks DR, Crisman TJ, Shih MY, Mottahedeh J, Gao F, Sperry J, Garrett MC, Yong WH, Cloughesy TF, Liau LM, Lai A, Coppola G, Kornblum HI. PMID: 27116978; PMCID: PMC5035518.
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PubMed Mentions:
49 Fields:
Translation:
HumansCells
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Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma. Mol Cancer Ther. 2016 06; 15(6):1271-8.
Laks DR, Ta L, Crisman TJ, Gao F, Coppola G, Radu CG, Nathanson DA, Kornblum HI. PMID: 27196770; PMCID: PMC4893966.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Neural Stem Cells (NSCs) and Proteomics. Mol Cell Proteomics. 2016 Feb; 15(2):344-54.
Shoemaker LD, Kornblum HI. PMID: 26494823; PMCID: PMC4739658.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
-
MELK-a conserved kinase: functions, signaling, cancer, and controversy. Clin Transl Med. 2015; 4:11.
Ganguly R, Mohyeldin A, Thiel J, Kornblum HI, Beullens M, Nakano I. PMID: 25852826; PMCID: PMC4385133.
View in:
PubMed Mentions:
64 Fields:
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Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells. Stem Cell Reports. 2014 Nov 11; 3(5):725-34.
Le Belle JE, Sperry J, Ngo A, Ghochani Y, Laks DR, López-Aranda M, Silva AJ, Kornblum HI. PMID: 25418720; PMCID: PMC4235743.
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PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
-
Maternal embryonic leucine zipper kinase: key kinase for stem cell phenotype in glioma and other cancers. Mol Cancer Ther. 2014 Jun; 13(6):1393-8.
Ganguly R, Hong CS, Smith LG, Kornblum HI, Nakano I. PMID: 24795222; PMCID: PMC4048631.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone. Stem Cell Res. 2014 Jul; 13(1):48-60.
Thomsen GM, Le Belle JE, Harnisch JA, Mc Donald WS, Hovda DA, Sofroniew MV, Kornblum HI, Harris NG. PMID: 24835668; PMCID: PMC4096985.
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PubMed Mentions:
14 Fields:
Translation:
Animals
-
Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition. PLoS One. 2014; 9(4):e92546.
Minata M, Gu C, Joshi K, Nakano-Okuno M, Hong C, Nguyen CH, Kornblum HI, Molla A, Nakano I. PMID: 24739874; PMCID: PMC3989164.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors. Mol Cancer Res. 2014 May; 12(5):694-702.
Panosyan EH, Wang Y, Xia P, Lee WN, Pak Y, Laks DR, Lin HJ, Moore TB, Cloughesy TF, Kornblum HI, Lasky JL. PMID: 24505127; PMCID: PMC4020976.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation. Hum Mol Genet. 2014 Jul 01; 23(13):3481-9.
Lee H, Lin MC, Kornblum HI, Papazian DM, Nelson SF. PMID: 24501278; PMCID: PMC4049306.
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PubMed Mentions:
63 Fields:
Translation:
Humans
-
Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science. 2014 Jan 03; 343(6166):72-6.
Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, Mischel PS. PMID: 24310612; PMCID: PMC4049335.
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PubMed Mentions:
316 Fields:
Translation:
HumansAnimalsCells
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MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Stem Cells. 2013 Jun; 31(6):1051-63.
Joshi K, Banasavadi-Siddegowda Y, Mo X, Kim SH, Mao P, Kig C, Nardini D, Sobol RW, Chow LM, Kornblum HI, Waclaw R, Beullens M, Nakano I. PMID: 23404835; PMCID: PMC3744761.
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PubMed Mentions:
115 Fields:
Translation:
HumansAnimalsCells
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De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discov. 2013 May; 3(5):534-47.
Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS. PMID: 23533263; PMCID: PMC3651754.
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Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas. J Natl Cancer Inst. 2012 Oct 03; 104(19):1458-69.
Chou AP, Chowdhury R, Li S, Chen W, Kim AJ, Piccioni DE, Selfridge JM, Mody RR, Chang S, Lalezari S, Lin J, Sanchez DE, Wilson RW, Garrett MC, Harry B, Mottahedeh J, Nghiemphu PL, Kornblum HI, Mischel PS, Prins RM, Yong WH, Cloughesy T, Nelson SF, Liau LM, Lai A. PMID: 22945948; PMCID: PMC3529615.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. J Neurooncol. 2012 Mar; 107(1):197-205.
Pope WB, Prins RM, Albert Thomas M, Nagarajan R, Yen KE, Bittinger MA, Salamon N, Chou AP, Yong WH, Soto H, Wilson N, Driggers E, Jang HG, Su SM, Schenkein DP, Lai A, Cloughesy TF, Kornblum HI, Wu H, Fantin VR, Liau LM. PMID: 22015945; PMCID: PMC3650613.
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PubMed Mentions:
150 Fields:
Translation:
Humans
-
Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells. Mol Cancer Res. 2011 Dec; 9(12):1668-85.
Liu Y, Ye F, Yamada K, Tso JL, Zhang Y, Nguyen DH, Dong Q, Soto H, Choe J, Dembo A, Wheeler H, Eskin A, Schmid I, Yong WH, Mischel PS, Cloughesy TF, Kornblum HI, Nelson SF, Liau LM, Tso CL. PMID: 22013079; PMCID: PMC3245317.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway. PLoS One. 2011; 6(9):e24217.
Jijiwa M, Demir H, Gupta S, Leung C, Joshi K, Orozco N, Huang T, Yildiz VO, Shibahara I, de Jesus JA, Yong WH, Mischel PS, Fernandez S, Kornblum HI, Nakano I. PMID: 21915300; PMCID: PMC3167830.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. Mol Cancer Ther. 2011 Oct; 10(10):1818-28.
Visnyei K, Onodera H, Damoiseaux R, Saigusa K, Petrosyan S, De Vries D, Ferrari D, Saxe J, Panosyan EH, Masterman-Smith M, Mottahedeh J, Bradley KA, Huang J, Sabatti C, Nakano I, Kornblum HI. PMID: 21859839; PMCID: PMC3191241.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. Neuro Oncol. 2011 Jun; 13(6):622-34.
Nakano I, Joshi K, Visnyei K, Hu B, Watanabe M, Lam D, Wexler E, Saigusa K, Nakamura Y, Laks DR, Mischel PS, Viapiano M, Kornblum HI. PMID: 21558073; PMCID: PMC3107094.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner. Cell Stem Cell. 2011 Jan 07; 8(1):59-71.
Le Belle JE, Orozco NM, Paucar AA, Saxe JP, Mottahedeh J, Pyle AD, Wu H, Kornblum HI. PMID: 21211782; PMCID: PMC3018289.
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PubMed Mentions:
374 Fields:
Translation:
HumansAnimalsCells
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MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states. Cell Stem Cell. 2010 Dec 03; 7(6):671-81.
Neveu P, Kye MJ, Qi S, Buchholz DE, Clegg DO, Sahin M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS. PMID: 21112562.
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PubMed Mentions:
61 Fields:
Translation:
HumansCells
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Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi-passageable neurosphere formation. Pediatr Blood Cancer. 2010 Oct; 55(4):644-51.
Panosyan EH, Laks DR, Masterman-Smith M, Mottahedeh J, Yong WH, Cloughesy TF, Lazareff JA, Mischel PS, Moore TB, Kornblum HI. PMID: 20589659; PMCID: PMC4017922.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Brain tumor stem cells as therapeutic targets in models of glioma. Yonsei Med J. 2010 Sep; 51(5):633-40.
Laks DR, Visnyei K, Kornblum HI. PMID: 20635435; PMCID: PMC2908869.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer Res. 2010 Aug 01; 70(15):6128-38.
Sun J, Masterman-Smith MD, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, DeJesus J, Kamei K, Lee KB, Wang H, Yu ZT, Lu YT, Hou S, Li K, Liu M, Zhang N, Wang S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathanson D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI, Yong WH, Graeber TG, Tseng HR. PMID: 20631065; PMCID: PMC3163840.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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A multipronged approach to the identification and study of an important oncogene in GBM. Cancer Cell. 2010 May 18; 17(5):417-8.
Kornblum HI. PMID: 20478522.
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PubMed Mentions:
1 Fields:
-
Hydrogel matrix to support stem cell survival after brain transplantation in stroke. Neurorehabil Neural Repair. 2010 Sep; 24(7):636-44.
Zhong J, Chan A, Morad L, Kornblum HI, Fan G, Carmichael ST. PMID: 20424193; PMCID: PMC4697440.
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PubMed Mentions:
101 Fields:
Translation:
AnimalsCells
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Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors. PLoS One. 2010 Feb 09; 5(2):e9121.
Shoemaker LD, Orozco NM, Geschwind DH, Whitelegge JP, Faull KF, Kornblum HI. PMID: 20161753; PMCID: PMC2817745.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. J Neurochem. 2009 Oct; 111(2):332-43.
Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A. PMID: 19694903.
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PubMed Mentions:
97 Fields:
Translation:
HumansAnimalsCells
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Endogenous Wnt signaling maintains neural progenitor cell potency. Stem Cells. 2009 May; 27(5):1130-41.
Wexler EM, Paucer A, Kornblum HI, Palmer TD, Plamer TD, Geschwind DH. PMID: 19418460; PMCID: PMC2782960.
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PubMed Mentions:
89 Fields:
Translation:
HumansAnimalsCells
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Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem Cells. 2009 Apr; 27(4):980-7.
Laks DR, Masterman-Smith M, Visnyei K, Angenieux B, Orozco NM, Foran I, Yong WH, Vinters HV, Liau LM, Lazareff JA, Mischel PS, Cloughesy TF, Horvath S, Kornblum HI. PMID: 19353526; PMCID: PMC3177534.
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PubMed Mentions:
119 Fields:
Translation:
HumansAnimalsCells
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Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells. 2009 Apr; 27(4):806-11.
Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE. PMID: 19350680; PMCID: PMC2895909.
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PubMed Mentions:
155 Fields:
Translation:
HumansCells
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Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS. Dis Model Mech. 2009 Mar-Apr; 2(3-4):189-95.
Karumbayaram S, Kelly TK, Paucar AA, Roe AJ, Umbach JA, Charles A, Goldman SA, Kornblum HI, Wiedau-Pazos M. PMID: 19259395; PMCID: PMC2650191.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci. 2009 Feb 11; 29(6):1874-86.
Gregorian C, Nakashima J, Le Belle J, Ohab J, Kim R, Liu A, Smith KB, Groszer M, Garcia AD, Sofroniew MV, Carmichael ST, Kornblum HI, Liu X, Wu H. PMID: 19211894; PMCID: PMC2754186.
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PubMed Mentions:
152 Fields:
Translation:
AnimalsCells
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Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cells. PLoS One. 2009; 4(1):e4213.
Kelly TK, Karsten SL, Geschwind DH, Kornblum HI. PMID: 19148290; PMCID: PMC2615219.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Methods for analysis of brain tumor stem cell and neural stem cell self-renewal. Methods Mol Biol. 2009; 568:37-56.
Nakano I, Kornblum HI. PMID: 19582420.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Ann N Y Acad Sci. 2008 Dec; 1147:383-94.
Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, Gazaryan I. PMID: 19076458; PMCID: PMC2921907.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Roles of insulin and transferrin in neural progenitor survival and proliferation. J Neurosci Res. 2008 Jun; 86(8):1884-94.
Erickson RI, Paucar AA, Jackson RL, Visnyei K, Kornblum H. PMID: 18293414.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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BMPing off glioma stem cells. Cancer Cell. 2008 Jan; 13(1):3-4.
Nakano I, Saigusa K, Kornblum HI. PMID: 18167333.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. J Neurosci Res. 2008 Jan; 86(1):48-60.
Nakano I, Masterman-Smith M, Saigusa K, Paucar AA, Horvath S, Shoemaker L, Watanabe M, Negro A, Bajpai R, Howes A, Lelievre V, Waschek JA, Lazareff JA, Freije WA, Liau LM, Gilbertson RJ, Cloughesy TF, Geschwind DH, Nelson SF, Mischel PS, Terskikh AV, Kornblum HI. PMID: 17722061.
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PubMed Mentions:
90 Fields:
Translation:
HumansAnimalsCells
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Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice. Dev Biol. 2008 Jan 01; 313(1):359-70.
Lelievre V, Seksenyan A, Nobuta H, Yong WH, Chhith S, Niewiadomski P, Cohen JR, Dong H, Flores A, Liau LM, Kornblum HI, Scott MP, Waschek JA. PMID: 18036580; PMCID: PMC2206628.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem Biol. 2007 Sep; 14(9):1019-30.
Saxe JP, Wu H, Kelly TK, Phelps ME, Sun YE, Kornblum HI, Huang J. PMID: 17884634; PMCID: PMC2758915.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Detection of a microRNA signal in an in vivo expression set of mRNAs. PLoS One. 2007 Aug 29; 2(8):e804.
Liu T, Papagiannakopoulos T, Puskar K, Qi S, Santiago F, Clay W, Lao K, Lee Y, Nelson SF, Kornblum HI, Doyle F, Petzold L, Shraiman B, Kosik KS. PMID: 17726534; PMCID: PMC1950084.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Stem Cells. 2007 Aug; 25(8):1975-84.
Nakano I, Dougherty JD, Kim K, Klement I, Geschwind DH, Kornblum HI. PMID: 17495110.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Introduction to neural stem cells. Stroke. 2007 Feb; 38(2 Suppl):810-6.
Kornblum HI. PMID: 17261745.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006. Stem Cells. 2007 Apr; 25(4):1070-88.
Cheng JC, Horwitz EM, Karsten SL, Shoemaker L, Kornblum HI, Malik P, Sakamoto KM. PMID: 17255523.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Brain tumor stem cells. Pediatr Res. 2006 Apr; 59(4 Pt 2):54R-8R.
Nakano I, Kornblum HI. PMID: 16549549.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes. Glia. 2006 Feb; 53(3):277-93.
Imura T, Nakano I, Kornblum HI, Sofroniew MV. PMID: 16267834.
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PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
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PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006 Jan 03; 103(1):111-6.
Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H. PMID: 16373498; PMCID: PMC1325011.
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PubMed Mentions:
143 Fields:
Translation:
AnimalsCells
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Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion. Exp Neurol. 2006 Feb; 197(2):465-74.
Visnyei K, Tatsukawa KJ, Erickson RI, Simonian S, Oknaian N, Carmichael ST, Kornblum HI. PMID: 16310773.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol. 2005 Aug 01; 170(3):413-27.
Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI. PMID: 16061694; PMCID: PMC2171475.
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PubMed Mentions:
78 Fields:
Translation:
AnimalsCells
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Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions. J Neurosci Res. 2005 Mar 01; 79(5):584-97.
Fox IJ, Kornblum HI. PMID: 15682390.
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PubMed Mentions:
48 Fields:
Translation:
Animals
-
Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones--implications for stem cell biology. Brain Res Dev Brain Res. 2004 Oct 15; 153(1):121-5.
Fox IJ, Paucar AA, Nakano I, Mottahedeh J, Dougherty JD, Kornblum HI. PMID: 15464225.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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[Cancer stem cells in pediatric brain tumors]. No Shinkei Geka. 2004 Aug; 32(8):827-34.
Nakano I, Hemmati HD, Kornblum HI. PMID: 15478649.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily. J Neurosci Res. 2004 Jul 15; 77(2):166-73.
Tiwari-Woodruff SK, Kaplan R, Kornblum HI, Bronstein JM. PMID: 15211584.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Metabolic correlates of lesion-specific plasticity: an in vivo imaging study. Brain Res. 2004 Mar 26; 1002(1-2):28-34.
Mir HM, Tatsukawa KJ, Carmichael ST, Chesselet MF, Kornblum HI. PMID: 14988030.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Evolution of diaschisis in a focal stroke model. Stroke. 2004 Mar; 35(3):758-63.
Carmichael ST, Tatsukawa K, Katsman D, Tsuyuguchi N, Kornblum HI. PMID: 14963280.
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PubMed Mentions:
56 Fields:
Translation:
Animals
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Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells. J Neurosci Res. 2004 Feb 01; 75(3):330-43.
Irvin DK, Nakano I, Paucar A, Kornblum HI. PMID: 14743446.
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39 Fields:
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AnimalsCells
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Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Dev Biol. 2003 Dec 15; 264(2):309-22.
Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI. PMID: 14651920.
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19 Fields:
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AnimalsCells
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Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15178-83.
Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI. PMID: 14645703; PMCID: PMC299944.
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762 Fields:
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HumansAnimalsCells
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Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks. Dev Biol. 2003 Sep 01; 261(1):165-82.
Karsten SL, Kudo LC, Jackson R, Sabatti C, Kornblum HI, Geschwind DH. PMID: 12941627.
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PubMed Mentions:
38 Fields:
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AnimalsCells
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Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain. J Comp Neurol. 2003 Jul 21; 462(2):265-73.
Fu L, Abu-Khalil A, Morrison RS, Geschwind DH, Kornblum HI. PMID: 12794748.
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PubMed Mentions:
8 Fields:
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HumansCells
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The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP. J Neurosci. 2003 Apr 01; 23(7):2824-32.
Imura T, Kornblum HI, Sofroniew MV. PMID: 12684469; PMCID: PMC6742109.
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PubMed Mentions:
115 Fields:
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AnimalsCells
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Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures. Dev Neurosci. 2003 Mar-Aug; 25(2-4):162-72.
Irvin DK, Dhaka A, Hicks C, Weinmaster G, Kornblum HI. PMID: 12966214.
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PubMed Mentions:
17 Fields:
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HumansAnimalsCells
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The RAS effector RIN1 modulates the formation of aversive memories. J Neurosci. 2003 Feb 01; 23(3):748-57.
Dhaka A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J. PMID: 12574403; PMCID: PMC6741936.
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28 Fields:
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HumansAnimalsCells
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Social communication in children with epilepsy. J Child Psychol Psychiatry. 2002 Feb; 43(2):245-53.
Caplan R, Guthrie D, Komo S, Siddarth P, Chayasirisobhon S, Kornblum H, Sankar R, Hansen R, Mitchell W, Shields WD. PMID: 11902603.
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PubMed Mentions:
6 Fields:
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Humans
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Comparison of thalamic populations in mammals and birds: expression of ErbB4 mRNA. Brain Res Bull. 2002 Feb-Mar 1; 57(3-4):455-61.
Bruce LL, Kornblum HI, Seroogy KB. PMID: 11923010.
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PubMed Mentions:
6 Fields:
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Animals
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Molecular markers in CNS stem cell research: hitting a moving target. Nat Rev Neurosci. 2001 Nov; 2(11):843-6.
Kornblum HI, Geschwind DH. PMID: 11715062.
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PubMed Mentions:
8 Fields:
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HumansAnimalsCells
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In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET). Nat Biotechnol. 2000 Jun; 18(6):655-60.
Kornblum HI, Araujo DM, Annala AJ, Tatsukawa KJ, Phelps ME, Cherry SR. PMID: 10835605.
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PubMed Mentions:
47 Fields:
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AnimalsCells