John J Colicelli

Title(s)Department Vice Chair, Biological Chemistry
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    Other Positions
    Title(s)Professor, Biological Chemistry

    Collapse Research 
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    A Novel Screen for Compounds that Outflank BCR-ABL Drug-Resistance
    NIH R01CA136699May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Mechanism of RIN1 Signaling in Neuronal Plasticity
    NIH R01NS046787Jul 1, 2003 - Jun 30, 2009
    Role: Principal Investigator
    NIH R01NS031911Aug 1, 1993 - May 31, 2001
    Role: Principal Investigator
    NIH R01CA056301Jul 2, 1992 - Jan 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Expression, purification, crystallization and X-ray data collection for RAS and its mutants. Data Brief. 2016 Mar; 6:423-7. Johnson CW, Buhrman G, Ting PY, Colicelli J, Mattos C. PMID: 26866052; PMCID: PMC4710794.
      View in: PubMed   Mentions: 11  
    2. Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. FASEB J. 2015 Sep; 29(9):3750-61. Ting PY, Johnson CW, Fang C, Cao X, Graeber TG, Mattos C, Colicelli J. PMID: 25999467; PMCID: PMC4550377.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    3. Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1. PLoS One. 2015; 10(3):e0121833. Ting PY, Damoiseaux R, Titz B, Bradley KA, Graeber TG, Fernández-Vega V, Bannister TD, Chase P, Nair R, Scampavia L, Hodder P, Spicer TP, Colicelli J. PMID: 25811598; PMCID: PMC4374917.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. The RAB5-GEF Function of RIN1 Regulates Multiple Steps During Listeria monocytogenes Infection. Traffic. 2015 Jul; 16(7):796. Balaji K, French CT, Miller JF, Colicelli J. PMID: 26050999.
      View in: PubMed   Mentions:    Fields:    
    5. The RAB5-GEF function of RIN1 regulates multiple steps during Listeria monocytogenes infection. Traffic. 2014 Nov; 15(11):1206-18. Balaji K, French CT, Miller JF, Colicelli J. PMID: 25082076; PMCID: PMC4282165.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):E4904-12. Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA. PMID: 24191014; PMCID: PMC3864319.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    7. RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases. Commun Integr Biol. 2013 Sep 01; 6(5):e25421. Balaji K, Colicelli J. PMID: 24265854; PMCID: PMC3829955.
      View in: PubMed   Mentions: 6  
    8. RIN3 is a negative regulator of mast cell responses to SCF. PLoS One. 2012; 7(11):e49615. Janson C, Kasahara N, Prendergast GC, Colicelli J. PMID: 23185384; PMCID: PMC3502454.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    9. RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR. J Cell Sci. 2012 Dec 01; 125(Pt 23):5887-96. Balaji K, Mooser C, Janson CM, Bliss JM, Hojjat H, Colicelli J. PMID: 22976291; PMCID: PMC3575715.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    10. ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1. Leukemia. 2011 Feb; 25(2):290-300. Thai M, Ting PY, McLaughlin J, Cheng D, Müschen M, Witte ON, Colicelli J. PMID: 21102429; PMCID: PMC3049868.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    11. ABL tyrosine kinases: evolution of function, regulation, and specificity. Sci Signal. 2010 Sep 14; 3(139):re6. Colicelli J. PMID: 20841568; PMCID: PMC2954126.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansAnimalsCells
    12. Signal transduction: RABGEF1 fingers RAS for ubiquitination. Curr Biol. 2010 Aug 10; 20(15):R630-2. Colicelli J. PMID: 20692608; PMCID: PMC2950067.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Fear learning and extinction are linked to neuronal plasticity through Rin1 signaling. J Neurosci Res. 2010 Mar; 88(4):917-26. Bliss JM, Gray EE, Dhaka A, O'Dell TJ, Colicelli J. PMID: 19830836; PMCID: PMC2864017.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    14. Regulated expression of the Ras effector Rin1 in forebrain neurons. Mol Cell Neurosci. 2010 Jan; 43(1):108-16. Dzudzor B, Huynh L, Thai M, Bliss JM, Nagaoka Y, Wang Y, Ch'ng TH, Jiang M, Martin KC, Colicelli J. PMID: 19837165; PMCID: PMC2818459.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    15. Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms. J Biol Chem. 2008 Nov 14; 283(46):31401-7. Cao X, Tanis KQ, Koleske AJ, Colicelli J. PMID: 18796434; PMCID: PMC2581583.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    16. The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12539-44. Deininger K, Eder M, Kramer ER, Zieglgänsberger W, Dodt HU, Dornmair K, Colicelli J, Klein R. PMID: 18723684; PMCID: PMC2527947.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    17. Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration. Mol Cell Biol. 2008 Mar; 28(5):1573-83. Hu H, Milstein M, Bliss JM, Thai M, Malhotra G, Huynh LC, Colicelli J. PMID: 18160707; PMCID: PMC2258770.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    18. RIN1 is a breast tumor suppressor gene. Cancer Res. 2007 Dec 15; 67(24):11510-6. Milstein M, Mooser CK, Hu H, Fejzo M, Slamon D, Goodglick L, Dry S, Colicelli J. PMID: 18089779; PMCID: PMC2950063.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    19. Proteomic identification of the cerebral cavernous malformation signaling complex. J Proteome Res. 2007 Nov; 6(11):4343-55. Hilder TL, Malone MH, Bencharit S, Colicelli J, Haystead TA, Johnson GL, Wu CC. PMID: 17900104.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    20. An intensive primary-literature-based teaching program directly benefits undergraduate science majors and facilitates their transition to doctoral programs. CBE Life Sci Educ. 2006; 5(4):340-7. Kozeracki CA, Carey MF, Colicelli J, Levis-Fitzgerald M, Grossel M. PMID: 17146041; PMCID: PMC1681356.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    21. The RIN family of Ras effectors. Methods Enzymol. 2006; 407:335-44. Bliss JM, Venkatesh B, Colicelli J. PMID: 16757336.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    22. RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. Curr Biol. 2005 May 10; 15(9):815-23. Hu H, Bliss JM, Wang Y, Colicelli J. PMID: 15886098.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    23. Human RAS superfamily proteins and related GTPases. Sci STKE. 2004 Sep 07; 2004(250):RE13. Colicelli J. PMID: 15367757; PMCID: PMC2828947.
      View in: PubMed   Mentions: 361     Fields:    Translation:HumansAnimalsCells
    24. The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis. Biochemistry. 2003 Nov 18; 42(45):13220-6. Huai Q, Colicelli J, Ke H. PMID: 14609333.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    25. The RAS effector RIN1 modulates the formation of aversive memories. J Neurosci. 2003 Feb 01; 23(3):748-57. Dhaka A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J. PMID: 12574403; PMCID: PMC6741936.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    26. The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. Mol Cell Biol. 2002 Feb; 22(3):916-26. Wang Y, Waldron RT, Dhaka A, Patel A, Riley MM, Rozengurt E, Colicelli J. PMID: 11784866; PMCID: PMC133556.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    27. Molecular docking of competitive phosphodiesterase inhibitors. Mol Pharmacol. 2002 Jan; 61(1):20-5. Dym O, Xenarios I, Ke H, Colicelli J. PMID: 11752202.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. RAS interaction with effector target RIN1. Methods Enzymol. 2001; 332:139-51. Wang Y, Colicelli J. PMID: 11305092.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    29. BCR/ABL inhibition by an escort/phosphatase fusion protein. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12233-8. Lim YM, Wong S, Lau G, Witte ON, Colicelli J. PMID: 11027300; PMCID: PMC17324.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    30. Human ERK1 induces filamentous growth and cell wall remodeling pathways in Saccharomyces cerevisiae. J Biol Chem. 2000 Jul 07; 275(27):20638-46. Atienza JM, Suh M, Xenarios I, Landgraf R, Colicelli J. PMID: 10787425.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Identification of inhibitor specificity determinants in a mammalian phosphodiesterase. J Biol Chem. 1999 Feb 19; 274(8):4839-47. Atienza JM, Susanto D, Huang C, McCarty AS, Colicelli J. PMID: 9988724.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    32. Yeast model system for study of mammalian phosphodiesterases. Methods. 1998 Jan; 14(1):35-42. Atienza JM, Colicelli J. PMID: 9500856.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    33. Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. Immunity. 1997 Jun; 6(6):773-82. Afar DE, Han L, McLaughlin J, Wong S, Dhaka A, Parmar K, Rosenberg N, Witte ON, Colicelli J. PMID: 9208849.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    34. Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):4954-9. Han L, Wong D, Dhaka A, Afar D, White M, Xie W, Herschman H, Witte O, Colicelli J. PMID: 9144171; PMCID: PMC24612.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    35. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. Mol Cell Biol. 1996 Dec; 16(12):6698-706. Spain BH, Bowdish KS, Pacal AR, Staub SF, Koo D, Chang CY, Xie W, Colicelli J. PMID: 8943324; PMCID: PMC231672.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    36. Truncated forms of a novel yeast protein suppress the lethality of a G protein alpha subunit deficiency by interacting with the beta subunit. J Biol Chem. 1995 Oct 27; 270(43):25435-44. Spain BH, Koo D, Ramakrishnan M, Dzudzor B, Colicelli J. PMID: 7592711.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    37. A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1. Mol Cell Biol. 1995 Mar; 15(3):1318-23. Han L, Colicelli J. PMID: 7862125; PMCID: PMC230355.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    38. Mutational mapping of kinetic and pharmacological properties of a human cardiac cAMP phosphodiesterase. J Biol Chem. 1994 Dec 02; 269(48):30676-81. Pillai R, Staub SF, Colicelli J. PMID: 7982987.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    39. Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11970-4. Pillai R, Kytle K, Reyes A, Colicelli J. PMID: 7505450; PMCID: PMC48107.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells