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John J Colicelli

Title(s)Professor, Biological Chemistry
SchoolMedicine
Address760 Westwood Plaza 337
Los Angeles CA 90024
Phone51251
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    Collapse Research 
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    A Novel Screen for Compounds that Outflank BCR-ABL Drug-Resistance
    NIH/NCI R01CA136699May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Mechanism of RIN1 Signaling in Neuronal Plasticity
    NIH/NINDS R01NS046787Jul 1, 2003 - Jun 30, 2009
    Role: Principal Investigator
    MECHANISM OF ENZYME INHIBITION BY PHARMACOLOGICAL AGENTS
    NIH/NINDS R01NS031911Aug 1, 1993 - May 31, 2001
    Role: Principal Investigator
    EFFECTORS AND REGULATORS OF NORMAL AND ONCOGENIC RAS
    NIH/NCI R01CA056301Jul 2, 1992 - Jun 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1. PLoS One. 2015; 10(3):e0121833. Ting PY, Damoiseaux R, Titz B, Bradley KA, Graeber TG, Fernández-Vega V, Bannister TD, Chase P, Nair R, Scampavia L, Hodder P, Spicer TP, Colicelli J. PMID: 25811598.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):E4904-12. Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA. PMID: 24191014.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    3. RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases. Commun Integr Biol. 2013 Sep 01; 6(5):e25421. Balaji K, Colicelli J. PMID: 24265854.
      View in: PubMed   Mentions:
    4. RIN3 is a negative regulator of mast cell responses to SCF. PLoS One. 2012; 7(11):e49615. Janson C, Kasahara N, Prendergast GC, Colicelli J. PMID: 23185384.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    5. RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR. J Cell Sci. 2012 Dec 01; 125(Pt 23):5887-96. Balaji K, Mooser C, Janson CM, Bliss JM, Hojjat H, Colicelli J. PMID: 22976291.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    6. ABL tyrosine kinases: evolution of function, regulation, and specificity. Sci Signal. 2010 Sep 14; 3(139):re6. Colicelli J. PMID: 20841568.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    7. Signal transduction: RABGEF1 fingers RAS for ubiquitination. Curr Biol. 2010 Aug 10; 20(15):R630-2. Colicelli J. PMID: 20692608.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Fear learning and extinction are linked to neuronal plasticity through Rin1 signaling. J Neurosci Res. 2010 Mar; 88(4):917-26. Bliss JM, Gray EE, Dhaka A, O'Dell TJ, Colicelli J. PMID: 19830836.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms. J Biol Chem. 2008 Nov 14; 283(46):31401-7. Cao X, Tanis KQ, Koleske AJ, Colicelli J. PMID: 18796434.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    10. Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration. Mol Cell Biol. 2008 Mar; 28(5):1573-83. Hu H, Milstein M, Bliss JM, Thai M, Malhotra G, Huynh LC, Colicelli J. PMID: 18160707.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    11. Proteomic identification of the cerebral cavernous malformation signaling complex. J Proteome Res. 2007 Nov; 6(11):4343-55. Hilder TL, Malone MH, Bencharit S, Colicelli J, Haystead TA, Johnson GL, Wu CC. PMID: 17900104.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    12. An intensive primary-literature-based teaching program directly benefits undergraduate science majors and facilitates their transition to doctoral programs. CBE Life Sci Educ. 2006; 5(4):340-7. Kozeracki CA, Carey MF, Colicelli J, Levis-Fitzgerald M, Grossel M. PMID: 17146041.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    13. The RIN family of Ras effectors. Methods Enzymol. 2006; 407:335-44. Bliss JM, Venkatesh B, Colicelli J. PMID: 16757336.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    14. RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. Curr Biol. 2005 May 10; 15(9):815-23. Hu H, Bliss JM, Wang Y, Colicelli J. PMID: 15886098.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    15. Human RAS superfamily proteins and related GTPases. Sci STKE. 2004 Sep 07; 2004(250):RE13. Colicelli J. PMID: 15367757.
      View in: PubMed   Mentions: 231     Fields:    Translation:HumansAnimalsCells
    16. The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis. Biochemistry. 2003 Nov 18; 42(45):13220-6. Huai Q, Colicelli J, Ke H. PMID: 14609333.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    17. The RAS effector RIN1 modulates the formation of aversive memories. J Neurosci. 2003 Feb 01; 23(3):748-57. Dhaka A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J. PMID: 12574403.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    18. The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. Mol Cell Biol. 2002 Feb; 22(3):916-26. Wang Y, Waldron RT, Dhaka A, Patel A, Riley MM, Rozengurt E, Colicelli J. PMID: 11784866.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    19. Molecular docking of competitive phosphodiesterase inhibitors. Mol Pharmacol. 2002 Jan; 61(1):20-5. Dym O, Xenarios I, Ke H, Colicelli J. PMID: 11752202.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells