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Richard T Waldron

Title(s)Associate Adjunct Professor, Medicine
SchoolMedicine
Address760 Westwood Plaza B8-146
Los Angeles CA 90024
Phone(310) 473-4731
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    Oxidation Signaling via Protein Kinase D/Jun in GI Cells
    NIH/NIDDK R21DK071783Aug 1, 2007 - Jul 31, 2010
    Role: Principal Investigator
    OXIDATIVE SIGNALING THROUGH PROTEIN KINASE D
    NIH/NIDDK K01DK002834Jul 1, 2000 - May 31, 2004
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting the CBP/ß-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells. Cancers (Basel). 2020 Jun 05; 12(6). Che M, Kweon SM, Teo JL, Yuan YC, Melstrom LG, Waldron RT, Lugea A, Urrutia RA, Pandol SJ, Lai KKY. PMID: 32516943.
      View in: PubMed   Mentions:
    2. Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells. Cells. 2020 01 18; 9(1). Dalva M, Lavik IK, El Jellas K, Gravdal A, Lugea A, Pandol SJ, Njølstad PR, Waldron RT, Fjeld K, Johansson BB, Molven A. PMID: 31963687.
      View in: PubMed   Mentions:    Fields:    
    3. Yes-Associated Protein 1 Plays Major Roles in Pancreatic Stellate Cell Activation and Fibroinflammatory Responses. Front Physiol. 2019; 10:1467. Hu C, Yang J, Su HY, Waldron RT, Zhi M, Li L, Xia Q, Pandol SJ, Lugea A. PMID: 31849712.
      View in: PubMed   Mentions:
    4. Brake adjustment: Ca2+ entry pathway provides a novel target for acute pancreatitis therapy. Ann Transl Med. 2019 Dec; 7(Suppl 8):S284. Waldron RT, Lugea A, Pandol SJ. PMID: 32016003.
      View in: PubMed   Mentions:
    5. Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis. Biochim Biophys Acta Mol Basis Dis. 2019 11 01; 1865(11):165530. Piplani H, Marek-Iannucci S, Sin J, Hou J, Takahashi T, Sharma A, de Freitas Germano J, Waldron RT, Saadaeijahromi H, Song Y, Gulla A, Wu B, Lugea A, Andres AM, Gaisano HY, Gottlieb RA, Pandol SJ. PMID: 31398467.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. New-Onset Diabetes Mellitus After Chronic Pancreatitis Diagnosis: A Systematic Review and Meta-analysis. Pancreas. 2019 08; 48(7):868-875. Zhu X, Liu D, Wei Q, Lin H, Zhi M, Chen Y, Qi L, Waldron RT, Lugea A, Pandol SJ, Li L. PMID: 31268977.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Incidence of New Onset Diabetes Mellitus Secondary to Acute Pancreatitis: A Systematic Review and Meta-Analysis. Front Physiol. 2019; 10:637. Zhi M, Zhu X, Lugea A, Waldron RT, Pandol SJ, Li L. PMID: 31231233.
      View in: PubMed   Mentions:
    8. The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis. J Physiol. 2019 06; 597(12):3085-3105. Waldron RT, Chen Y, Pham H, Go A, Su HY, Hu C, Wen L, Husain SZ, Sugar CA, Roos J, Ramos S, Lugea A, Dunn M, Stauderman K, Pandol SJ. PMID: 31050811.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    9. Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders. Pancreas. 2019 04; 48(4):459-470. Gukovskaya AS, Gorelick FS, Groblewski GE, Mareninova OA, Lugea A, Antonucci L, Waldron RT, Habtezion A, Karin M, Pandol SJ, Gukovsky I. PMID: 30973461.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Proteomic Identification of Novel Plasma Biomarkers and Pathobiologic Pathways in Alcoholic Acute Pancreatitis. Front Physiol. 2018; 9:1215. Waldron RT, Lugea A, Gulla A, Pandol SJ. PMID: 30214418.
      View in: PubMed   Mentions:
    11. Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. Cell Mol Gastroenterol Hepatol. 2018; 5(4):479-497. Waldron RT, Su HY, Piplani H, Capri J, Cohn W, Whitelegge JP, Faull KF, Sakkiah S, Abrol R, Yang W, Zhou B, Freeman MR, Pandol SJ, Lugea A. PMID: 29930975.
      View in: PubMed   Mentions: 4     Fields:    
    12. The Differential Role of Human Cationic Trypsinogen (PRSS1) p.R122H Mutation in Hereditary and Nonhereditary Chronic Pancreatitis: A Systematic Review and Meta-Analysis. Gastroenterol Res Pract. 2017; 2017:9505460. Hu C, Wen L, Deng L, Zhang C, Lugea A, Su HY, Waldron RT, Pandol SJ, Xia Q. PMID: 29118810.
      View in: PubMed   Mentions:
    13. Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis. Am J Pathol. 2017 Dec; 187(12):2726-2743. Lugea A, Waldron RT, Mareninova OA, Shalbueva N, Deng N, Su HY, Thomas DD, Jones EK, Messenger SW, Yang J, Hu C, Gukovsky I, Liu Z, Groblewski GE, Gukovskaya AS, Gorelick FS, Pandol SJ. PMID: 28935577.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice. PLoS One. 2017; 12(9):e0184455. Chang HH, Moro A, Takakura K, Su HY, Mo A, Nakanishi M, Waldron RT, French SW, Dawson DW, Hines OJ, Li G, Go VLW, Sinnett-Smith J, Pandol SJ, Lugea A, Gukovskaya AS, Duff MO, Rosenberg DW, Rozengurt E, Eibl G. PMID: 28886117.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    15. The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells. Gastroenterology. 2017 12; 153(6):1674-1686. Lugea A, Gerloff A, Su HY, Xu Z, Go A, Hu C, French SW, Wilson JS, Apte MV, Waldron RT, Pandol SJ. PMID: 28847752.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    16. Exosome-Mediated Intercellular Communication Between Stellate Cells and Cancer Cells in Pancreatic Ductal Adenocarcinoma. Pancreas. 2017 01; 46(1):1-4. Lugea A, Waldron RT. PMID: 27977625.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G675-G687. Yang J, Waldron RT, Su HY, Moro A, Chang HH, Eibl G, Ferreri K, Kandeel FR, Lugea A, Li L, Pandol SJ. PMID: 27609771.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells. PLoS One. 2016; 11(2):e0148999. Su HY, Waldron RT, Gong R, Ramanujan VK, Pandol SJ, Lugea A. PMID: 26849807.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. Pancreatology. 2015 Jul; 15(4 Suppl):S1-5. Lugea A, Waldron RT, Pandol SJ. PMID: 25736240.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    20. Diabetes, pancreatic cancer, and metformin therapy. Front Physiol. 2014; 5:426. Gong J, Robbins LA, Lugea A, Waldron RT, Jeon CY, Pandol SJ. PMID: 25426078.
      View in: PubMed   Mentions:
    21. Genetic inhibition of protein kinase Ce attenuates necrosis in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 01; 307(5):G550-63. Liu Y, Yuan J, Tan T, Jia W, Lugea A, Mareninova O, Waldron RT, Pandol SJ. PMID: 25035113.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    22. Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis. Gastroenterology. 2013 Feb; 144(2):437-446.e6. Shalbueva N, Mareninova OA, Gerloff A, Yuan J, Waldron RT, Pandol SJ, Gukovskaya AS. PMID: 23103769.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    23. Differential PKC-dependent and -independent PKD activation by G protein a subunits of the Gq family: selective stimulation of PKD Ser748 autophosphorylation by Gaq. Cell Signal. 2012 Apr; 24(4):914-21. Waldron RT, Innamorati G, Torres-Marquez ME, Sinnett-Smith J, Rozengurt E. PMID: 22227248.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Genes, tolerance and systemic autoimmunity. Autoimmun Rev. 2012 Jul; 11(9):664-9. Singh RP, Waldron RT, Hahn BH. PMID: 22155015.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    25. Drinking and driving pancreatitis: links between endoplasmic reticulum stress and autophagy. Autophagy. 2011 Jul; 7(7):783-5. Lugea A, Waldron RT, French SW, Pandol SJ. PMID: 21460613.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway. Biochem Biophys Res Commun. 2010 Jan 01; 391(1):63-8. Torres-Marquez E, Sinnett-Smith J, Guha S, Kui R, Waldron RT, Rey O, Rozengurt E. PMID: 19896460.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    27. Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation. J Biol Chem. 2009 May 15; 284(20):13434-45. Sinnett-Smith J, Jacamo R, Kui R, Wang YM, Young SH, Rey O, Waldron RT, Rozengurt E. PMID: 19289471.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    28. Protein kinase D isozymes activation and localization during mitosis. Exp Cell Res. 2008 Oct 01; 314(16):3057-68. Papazyan R, Doche M, Waldron RT, Rozengurt E, Moyer MP, Rey O. PMID: 18692497.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    29. Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation. J Biol Chem. 2008 May 09; 283(19):12877-87. Jacamo R, Sinnett-Smith J, Rey O, Waldron RT, Rozengurt E. PMID: 18337243.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    30. Identification of a novel phosphorylation site in c-jun directly targeted in vitro by protein kinase D. Biochem Biophys Res Commun. 2007 May 04; 356(2):361-7. Waldron RT, Whitelegge JP, Faull KF, Rozengurt E. PMID: 17359934.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    31. The nuclear import of protein kinase D3 requires its catalytic activity. J Biol Chem. 2006 Feb 24; 281(8):5149-57. Rey O, Papazyan R, Waldron RT, Young SH, Lippincott-Schwartz J, Jacamo R, Rozengurt E. PMID: 16380377.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. Protein kinase D signaling. J Biol Chem. 2005 Apr 08; 280(14):13205-8. Rozengurt E, Rey O, Waldron RT. PMID: 15701647.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    33. Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D. J Biol Chem. 2004 Jun 25; 279(26):27482-93. Waldron RT, Rey O, Zhukova E, Rozengurt E. PMID: 15084589.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    34. Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain. J Biol Chem. 2003 Jan 03; 278(1):154-63. Waldron RT, Rozengurt E. PMID: 12407104.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    35. Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus. Oncogene. 2002 Mar 28; 21(14):2154-60. Hurd C, Waldron RT, Rozengurt E. PMID: 11948398.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    36. The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. Mol Cell Biol. 2002 Feb; 22(3):916-26. Wang Y, Waldron RT, Dhaka A, Patel A, Riley MM, Rozengurt E, Colicelli J. PMID: 11784866.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    37. Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo. J Biol Chem. 2001 Aug 31; 276(35):32606-15. Waldron RT, Rey O, Iglesias T, Tugal T, Cantrell D, Rozengurt E. PMID: 11410586.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    38. Oxidative stress induces protein kinase D activation in intact cells. Involvement of Src and dependence on protein kinase C. J Biol Chem. 2000 Jun 02; 275(22):17114-21. Waldron RT, Rozengurt E. PMID: 10748111.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    39. The pleckstrin homology domain of protein kinase D interacts preferentially with the eta isoform of protein kinase C. J Biol Chem. 1999 Apr 02; 274(14):9224-30. Waldron RT, Iglesias T, Rozengurt E. PMID: 10092595.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    40. Phosphorylation-dependent protein kinase D activation. Electrophoresis. 1999 Feb; 20(2):382-90. Waldron RT, Iglesias T, Rozengurt E. PMID: 10197446.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
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