Oscar Joe Hines

Title(s)Department Chair, Surgery
SchoolMedicine
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    Title(s)Professor, Surgery


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    Collapse Overview
    Dr. O. Joe Hines holds the William P. Longmire, Jr. Chair in Surgery. He previously held the Robert and Kelly Day Chair in General Surgery (11/1/2011 - 6/30/2023).

    Collapse Research 
    Collapse Research Activities and Funding
    The Role of CXCR2 in Pancreatic Cancer
    NIH R21CA124609Jul 1, 2007 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cataloging formal medical student surgical funding opportunities: A retrospective characterization. Surg Open Sci. 2023 Dec; 16:244-247. Wang A, Goel K, Shlobin NA, Liu T, Liou M, Thum JA, Hines OJ, Holly LT. PMID: 38076571; PMCID: PMC10697981.
      View in: PubMed   Mentions:
    2. Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice. Sci Rep. 2023 09 26; 13(1):16144. Teper Y, Ye L, Waldron RT, Lugea A, Sun X, Sinnett-Smith J, Hines OJ, Pandol SJ, Rozengurt E, Eibl G. PMID: 37752238; PMCID: PMC10522691.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. A Call to Action: Improving the Surgical Training Experience for Residents Underrepresented in Medicine. Ann Surg. 2023 02 01; 277(2):e254-e256. Liu TP, Wang A, Sheppard WL, Stavrakis AI, Hines OJ, McIntosh D. PMID: 36120865.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Statins Inhibit Inflammatory Cytokine Production by Macrophages and Acinar-to-Ductal Metaplasia of Pancreatic Cells. Gastro Hep Adv. 2022; 1(4):640-651. Ako S, Teper Y, Ye L, Sinnett-Smith J, Hines OJ, Rozengurt E, Eibl G. PMID: 36313271; PMCID: PMC9615480.
      View in: PubMed   Mentions:
    5. UCLA Health: Bridging academic surgery with a health system community expansion. Surgery. 2022 04; 171(4):1111-1114. Lee S, Hines OJ. PMID: 34895910.
      View in: PubMed   Mentions:    Fields:    
    6. Management of severe acute pancreatitis. BMJ. 2019 12 02; 367:l6227. Hines OJ, Pandol SJ. PMID: 31791953.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    7. A Prognostic Scoring System for the Prediction of Metastatic Recurrence Following Curative Resection of Pancreatic Neuroendocrine Tumors. J Gastrointest Surg. 2019 07; 23(7):1392-1400. Sho S, Court CM, Winograd P, Toste PA, Pisegna JR, Lewis M, Donahue TR, Hines OJ, Reber HA, Dawson DW, Tomlinson JS. PMID: 30353489; PMCID: PMC6736531.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    8. Reply. Pancreas. 2017 01; 46(1):e2. Hines OJ. PMID: 27977630.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Robust Early Inflammation of the Peripancreatic Visceral Adipose Tissue During Diet-Induced Obesity in the KrasG12D Model of Pancreatic Cancer. Pancreas. 2016 Mar; 45(3):458-65. Hertzer KM, Xu M, Moro A, Dawson DW, Du L, Li G, Chang HH, Stark AP, Jung X, Hines OJ, Eibl G. PMID: 26495779; PMCID: PMC4854638.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    10. Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA- and EP1/Ca2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1. Am J Physiol Cell Physiol. 2015 Nov 15; 309(10):C639-49. Chang HH, Young SH, Sinnett-Smith J, Chou CE, Moro A, Hertzer KM, Hines OJ, Rozengurt E, Eibl G. PMID: 26310818; PMCID: PMC4652080.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    11. Factors associated with general surgery residents' desire to leave residency programs: a multi-institutional study. JAMA Surg. 2014 Sep; 149(9):948-53. Gifford E, Galante J, Kaji AH, Nguyen V, Nelson MT, Sidwell RA, Hartranft T, Jarman B, Melcher M, Reeves M, Reid C, Jacobsen GR, Thompson J, Are C, Smith B, Arnell T, Hines OJ, de Virgilio C. PMID: 25075473.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    12. 2014 Society of University Surgeons presidential address. Surgery. 2014 Aug; 156(2):205-13. Hines OJ. PMID: 24957672.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Nonfunctional pancreatic neuroendocrine tumors <2 cm on preoperative imaging are associated with a low incidence of nodal metastasis and an excellent overall survival. J Gastrointest Surg. 2013 Dec; 17(12):2105-13. Toste PA, Kadera BE, Tatishchev SF, Dawson DW, Clerkin BM, Muthusamy R, Watson R, Tomlinson JS, Hines OJ, Reber HA, Donahue TR. PMID: 24101447.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    14. Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic cancer cells. Biochim Biophys Acta. 2013 Dec; 1833(12):2980-2987. Takahashi H, Chen MC, Pham H, Matsuo Y, Ishiguro H, Reber HA, Takeyama H, Hines OJ, Eibl G. PMID: 23954445; PMCID: PMC3834082.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    15. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev Res (Phila). 2013 Oct; 6(10):1064-73. Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G. PMID: 23943783; PMCID: PMC3835151.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    16. Perioperative antibiotics for surgical site infection in pancreaticoduodenectomy: does the SCIP-approved regimen provide adequate coverage? Surgery. 2013 Aug; 154(2):190-6. Donald GW, Sunjaya D, Lu X, Chen F, Clerkin B, Eibl G, Li G, Tomlinson JS, Donahue TR, Reber HA, Hines OJ. PMID: 23664266; PMCID: PMC4601575.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    17. The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo. Pancreas. 2013 Mar; 42(2):223-9. Angst E, Park JL, Moro A, Lu QY, Lu X, Li G, King J, Chen M, Reber HA, Go VL, Eibl G, Hines OJ. PMID: 23000892; PMCID: PMC3530623.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    18. Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells. Pancreas. 2012 Nov; 41(8):1306-15. Pham H, Chen M, Takahashi H, King J, Reber HA, Hines OJ, Pandol S, Eibl G. PMID: 22889981; PMCID: PMC3479318.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    19. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta. 2011 Aug; 1813(8):1465-74. Takahashi H, Chen MC, Pham H, Angst E, King JC, Park J, Brovman EY, Ishiguro H, Harris DM, Reber HA, Hines OJ, Gukovskaya AS, Go VL, Eibl G. PMID: 21596068; PMCID: PMC3123440.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    20. Cyclooxygenase-2 confers growth advantage to syngeneic pancreatic cancer cells. Pancreas. 2011 Apr; 40(3):453-9. Takahashi H, Li A, Dawson DW, Hines OJ, Reber HA, Eibl G. PMID: 21343834; PMCID: PMC3077942.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. CXCR2-Dependent Endothelial Progenitor Cell Mobilization in Pancreatic Cancer Growth. Transl Oncol. 2011 Feb 01; 4(1):20-8. Li A, Cheng XJ, Moro A, Singh RK, Hines OJ, Eibl G. PMID: 21286374; PMCID: PMC3026405.
      View in: PubMed   Mentions: 21  
    22. Impact of duct-to-mucosa pancreaticojejunostomy with external drainage of the pancreatic duct after pancreaticoduodenectomy. J Surg Res. 2011 Dec; 171(2):457-8. Assifi MM, Hines OJ. PMID: 21227462.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Minimally invasive approaches to infected pancreatic collections. Arch Surg. 2010 Sep; 145(9):825. Hines OJ. PMID: 20873002.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Invasive intraductal papillary mucinous neoplasm versus sporadic pancreatic adenocarcinoma: a stage-matched comparison of outcomes. Cancer. 2010 Jul 15; 116(14):3369-77. Wasif N, Bentrem DJ, Farrell JJ, Ko CY, Hines OJ, Reber HA, Tomlinson JS. PMID: 20564064; PMCID: PMC2902567.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    25. Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. Pancreas. 2010 Jul; 39(5):675-9. Angst E, Dawson DW, Nguyen A, Park J, Go VL, Reber HA, Hines OJ, Eibl G. PMID: 20173668; PMCID: PMC2895953.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    26. Impact of tumor grade on prognosis in pancreatic cancer: should we include grade in AJCC staging? Ann Surg Oncol. 2010 Sep; 17(9):2312-20. Wasif N, Ko CY, Farrell J, Wainberg Z, Hines OJ, Reber H, Tomlinson JS. PMID: 20422460; PMCID: PMC2924500.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    27. Howard A. Reber, M.D., Distinguished Professor of Surgery, UCLA School of Medicine. Langenbecks Arch Surg. 2010 Jun; 395(5):593-4. Hines OJ. PMID: 20383522; PMCID: PMC2890081.
      View in: PubMed   Mentions:    Fields:    
    28. Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. J Clin Oncol. 2010 Mar 10; 28(8):1358-65. Manuyakorn A, Paulus R, Farrell J, Dawson NA, Tze S, Cheung-Lau G, Hines OJ, Reber H, Seligson DB, Horvath S, Kurdistani SK, Guha C, Dawson DW. PMID: 20142597; PMCID: PMC2834495.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    29. Pancreatic surgery. Curr Opin Gastroenterol. 2009 Sep; 25(5):460-5. Hines OJ, Reber HA. PMID: 19550315.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer. Neoplasia. 2009 Feb; 11(2):196-206. Büchler P, Reber HA, Tomlinson JS, Hankinson O, Kallifatidis G, Friess H, Herr I, Hines OJ. PMID: 19177204; PMCID: PMC2631144.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    31. Utilization of parenteral nutrition following pancreaticoduodenectomy: is routine jejunostomy tube placement warranted? Dig Dis Sci. 2009 Jul; 54(7):1582-8. Yermilov I, Jain S, Sekeris E, Bentrem DJ, Hines OJ, Reber HA, Ko CY, Tomlinson JS. PMID: 18958617.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    32. Pancreatic surgery. Curr Opin Gastroenterol. 2008 Sep; 24(5):603-11. Hines OJ, Reber HA. PMID: 19122502.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    33. Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. Pancreas. 2008 Aug; 37(2):121-7. Hasan S, Satake M, Dawson DW, Funahashi H, Angst E, Go VL, Reber HA, Hines OJ, Eibl G. PMID: 18665070.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    34. Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm. Clin Gastroenterol Hepatol. 2008 Jul; 6(7):815-9; quiz 719. Tang RS, Weinberg B, Dawson DW, Reber H, Hines OJ, Tomlinson JS, Chaudhari V, Raman S, Farrell JJ. PMID: 18602036.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    35. Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2. Surgery. 2008 Jul; 144(1):57-65. Angst E, Reber HA, Hines OJ, Eibl G. PMID: 18571585; PMCID: PMC2601479.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    36. Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth. Pancreas. 2008 May; 36(4):353-62. Funahashi H, Satake M, Hasan S, Sawai H, Newman RA, Reber HA, Hines OJ, Eibl G. PMID: 18437081.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    37. PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer. Cancer. 2007 Oct 01; 110(7):1457-68. El Fitori J, Su Y, Büchler P, Ludwig R, Giese NA, Büchler MW, Quentmeier H, Hines OJ, Herr I, Friess H. PMID: 17676584.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    38. Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. Cancer Res. 2007 Aug 01; 67(15):7068-71. Funahashi H, Satake M, Dawson D, Huynh NA, Reber HA, Hines OJ, Eibl G. PMID: 17652141.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    39. Target therapy using a small molecule inhibitor against angiogenic receptors in pancreatic cancer. Neoplasia. 2007 Feb; 9(2):119-27. Büchler P, Reber HA, Roth MM, Shiroishi M, Friess H, Hines OJ. PMID: 17356708; PMCID: PMC1813933.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    40. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. J Gastrointest Surg. 2006 Nov; 10(9):1230-41; discussion 1242. Su Y, Büchler P, Gazdhar A, Giese N, Reber HA, Hines OJ, Giese T, Büchler MW, Friess H. PMID: 17114010.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    41. Pancreatic surgery. Curr Opin Gastroenterol. 2006 Sep; 22(5):520-6. Hines OJ, Reber HA. PMID: 16891883.
      View in: PubMed   Mentions: 1     Fields:    
    42. Resection of pancreatic neuroendocrine tumors: results of 70 cases. Arch Surg. 2006 Aug; 141(8):765-9; discussion 769-70. Kazanjian KK, Reber HA, Hines OJ. PMID: 16924083.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    43. Estrogen receptors in pancreatic tumors. Pancreas. 2006 Aug; 33(2):119-27. Satake M, Sawai H, Go VL, Satake K, Reber HA, Hines OJ, Eibl G. PMID: 16868476.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    44. Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeats. Clin Chem. 2006 Jun; 52(6):1062-9. Umetani N, Kim J, Hiramatsu S, Reber HA, Hines OJ, Bilchik AJ, Hoon DS. PMID: 16723681.
      View in: PubMed   Mentions: 119     Fields:    Translation:Humans
    45. The clinical significance of MAGEA3 expression in pancreatic cancer. Int J Cancer. 2006 May 01; 118(9):2269-75. Kim J, Reber HA, Hines OJ, Kazanjian KK, Tran A, Ye X, Amersi FF, Martinez SR, Dry SM, Bilchik AJ, Hoon DS. PMID: 16331618.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    46. Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. Mol Cancer Res. 2006 Mar; 4(3):159-67. Sawai H, Liu J, Reber HA, Hines OJ, Eibl G. PMID: 16547153.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    47. Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis. Cancer Lett. 2006 Sep 28; 241(2):221-7. Wente MN, Keane MP, Burdick MD, Friess H, Büchler MW, Ceyhan GO, Reber HA, Strieter RM, Hines OJ. PMID: 16458421.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    48. Technique of pancreaticojejunostomy reconstruction after pancreaticoduodenectomy. J Hepatobiliary Pancreat Surg. 2006; 13(3):185-9. Hines OJ, Reber HA. PMID: 16708292.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    49. The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling. Cancer Res. 2005 Dec 15; 65(24):11536-44. Sawai H, Okada Y, Kazanjian K, Kim J, Hasan S, Hines OJ, Reber HA, Hoon DS, Eibl G. PMID: 16357163.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    50. The proteasome inhibitor MG132 induces apoptosis in human pancreatic cancer cells. Oncol Rep. 2005 Dec; 14(6):1635-8. Wente MN, Eibl G, Reber HA, Friess H, Büchler MW, Hines OJ. PMID: 16273269.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    51. The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg. 2005 Dec; 242(6):791-800, discussion 800-1. Büchler P, Gazdhar A, Schubert M, Giese N, Reber HA, Hines OJ, Giese T, Ceyhan GO, Müller M, Büchler MW, Friess H. PMID: 16327489; PMCID: PMC1409885.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    52. Combination therapy for advanced pancreatic cancer using Herceptin plus chemotherapy. Int J Oncol. 2005 Oct; 27(4):1125-30. Büchler P, Reber HA, Eibl G, Roth MA, Büchler MW, Friess H, Isacoff WH, Hines OJ. PMID: 16142331.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    53. Management of pancreatic fistulas after pancreaticoduodenectomy: results in 437 consecutive patients. Arch Surg. 2005 Sep; 140(9):849-54; discussion 854-6. Kazanjian KK, Hines OJ, Eibl G, Reber HA. PMID: 16172293.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    54. Pancreatic surgery. Curr Opin Gastroenterol. 2005 Sep; 21(5):568-72. Hines OJ, Reber HA. PMID: 16093771.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    55. Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer. Pancreas. 2005 Aug; 31(2):119-25. Wente MN, Jain A, Kono E, Berberat PO, Giese T, Reber HA, Friess H, Büchler MW, Reiter RE, Hines OJ. PMID: 16024997.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    56. Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res. 2005 Apr 01; 65(7):2738-45. Guha S, Eibl G, Kisfalvi K, Fan RS, Burdick M, Reber H, Hines OJ, Strieter R, Rozengurt E. PMID: 15805273.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    57. Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor. Cancer Res. 2005 Feb 01; 65(3):982-90. Eibl G, Takata Y, Boros LG, Liu J, Okada Y, Reber HA, Hines OJ. PMID: 15705899.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    58. Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysis. Gastrointest Endosc. 2004 Dec; 60(6):865-74. Targownik LE, Spiegel BM, Sack J, Hines OJ, Dulai GS, Gralnek IM, Farrell JJ. PMID: 15604999.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansPHPublic Health
    59. COX and PPAR: possible interactions in pancreatic cancer. Pancreas. 2004 Nov; 29(4):247-53. Eibl G, Reber HA, Hines OJ, Go VL. PMID: 15502639.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    60. Laparoscopic gastrojejunostomy for gastric outlet obstruction in pancreatic cancer. Am Surg. 2004 Oct; 70(10):910-3. Kazanjian KK, Reber HA, Hines OJ. PMID: 15529849.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    61. Pancreatic neoplasms. Curr Opin Gastroenterol. 2004 Sep; 20(5):452-8. Hines OJ, Reber HA. PMID: 15689678.
      View in: PubMed   Mentions: 1     Fields:    
    62. Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model. J Surg Res. 2004 Aug; 120(2):295-303. Büchler P, Reber HA, Lavey RS, Tomlinson J, Büchler MW, Friess H, Hines OJ. PMID: 15234226.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    63. Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression. Cancer. 2004 Jan 01; 100(1):201-10. Büchler P, Reber HA, Büchler MW, Friess H, Lavey RS, Hines OJ. PMID: 14692041.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    64. Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells. Clin Exp Metastasis. 2004; 21(4):285-92. Okada Y, Eibl G, Guha S, Duffy JP, Reber HA, Hines OJ. PMID: 15554384.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    65. Pancreatic cancer growth is inhibited by blockade of VEGF-RII. Surgery. 2003 Nov; 134(5):772-82. Büchler P, Reber HA, Ullrich A, Shiroiki M, Roth M, Büchler MW, Lavey RS, Friess H, Hines OJ. PMID: 14639356.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    66. Laparoscopic Nissen fundoplication improves quality of life in patients with atypical symptoms of gastroesophageal reflux. Am Surg. 2003 Oct; 69(10):833-8. Duffy JP, Maggard M, Hiyama DT, Atkinson JB, McFadden DW, Ko CY, Hines OJ. PMID: 14570358.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    67. Improved survival for adenocarcinoma of the ampulla of Vater: fifty-five consecutive resections. Arch Surg. 2003 Sep; 138(9):941-8; discussion 948-50. Duffy JP, Hines OJ, Liu JH, Ko CY, Cortina G, Isacoff WH, Nguyen H, Leonardi M, Tompkins RK, Reber HA. PMID: 12963649.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    68. Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer. Surgery. 2003 Aug; 134(2):293-9. Okada Y, Eibl G, Duffy JP, Reber HA, Hines OJ. PMID: 12947332.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    69. PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. Biochem Biophys Res Commun. 2003 Jul 11; 306(4):887-97. Eibl G, Bruemmer D, Okada Y, Duffy JP, Law RE, Reber HA, Hines OJ. PMID: 12821125.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    70. Prevention of metastatic pancreatic cancer growth in vivo by induction of apoptosis with genistein, a naturally occurring isoflavonoid. Pancreas. 2003 Apr; 26(3):264-73. Büchler P, Gukovskaya AS, Mouria M, Büchler MC, Büchler MW, Friess H, Pandol SJ, Reber HA, Hines OJ. PMID: 12657953.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    71. Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer. Mol Cancer. 2003 Jan 22; 2:12. Duffy JP, Eibl G, Reber HA, Hines OJ. PMID: 12605718; PMCID: PMC150383.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    72. The selective cyclooxygenase-2 inhibitor nimesulide induces apoptosis in pancreatic cancer cells independent of COX-2. Pancreas. 2003 Jan; 26(1):33-41. Eibl G, Reber HA, Wente MN, Hines OJ. PMID: 12499915.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    73. Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer. Pancreas. 2003 Jan; 26(1):56-64. Büchler P, Reber HA, Büchler M, Shrinkante S, Büchler MW, Friess H, Semenza GL, Hines OJ. PMID: 12499918.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    74. VEGF-RII influences the prognosis of pancreatic cancer. Ann Surg. 2002 Dec; 236(6):738-49; discussion 749. Büchler P, Reber HA, Büchler MW, Friess H, Hines OJ. PMID: 12454512; PMCID: PMC1422640.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    75. Human cytokine levels in nonperforated versus perforated appendicitis: molecular serum markers for extent of disease? Am Surg. 2002 Dec; 68(12):1033-7. Yoon DY, Chu J, Chandler C, Hiyama S, Thompson JE, Hines OJ. PMID: 12516803.
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    76. Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int J Cancer. 2002 Apr 10; 98(5):761-9. Mouria M, Gukovskaya AS, Jung Y, Buechler P, Hines OJ, Reber HA, Pandol SJ. PMID: 11920648.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    77. Outcomes from peptic ulcer surgery have not benefited from advances in medical therapy. Am Surg. 2002 Apr; 68(4):385-9. Towfigh S, Chandler C, Hines OJ, McFadden DW. PMID: 11952253.
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    78. Lysophosphatidic acid stimulates intestinal restitution via cytoskeletal activation and remodeling. J Surg Res. 2000 Jul; 92(1):23-8. Hines OJ, Ryder N, Chu J, McFadden D. PMID: 10864477.
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