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Hines, Oscar Joe

Title(s)Professor, Surgery
SchoolGeneral Surgery
Phone60441
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    Collapse Research 
    Collapse Research Activities and Funding
    The Role of CXCR2 in Pancreatic Cancer
    NIH/NCI R21CA124609Jul 1, 2007 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hines OJ, Pandol SJ. Management of severe acute pancreatitis. BMJ. 2019 12 02; 367:l6227. PMID: 31791953.
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    2. Sho S, Court CM, Winograd P, Toste PA, Pisegna JR, Lewis M, Donahue TR, Hines OJ, Reber HA, Dawson DW, Tomlinson JS. A Prognostic Scoring System for the Prediction of Metastatic Recurrence Following Curative Resection of Pancreatic Neuroendocrine Tumors. J Gastrointest Surg. 2019 Jul; 23(7):1392-1400. PMID: 30353489.
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    3. Hines OJ. Reply. Pancreas. 2017 01; 46(1):e2. PMID: 27977630.
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    4. Hertzer KM, Xu M, Moro A, Dawson DW, Du L, Li G, Chang HH, Stark AP, Jung X, Hines OJ, Eibl G. Robust Early Inflammation of the Peripancreatic Visceral Adipose Tissue During Diet-Induced Obesity in the KrasG12D Model of Pancreatic Cancer. Pancreas. 2016 Mar; 45(3):458-65. PMID: 26495779.
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    5. Chang HH, Young SH, Sinnett-Smith J, Chou CE, Moro A, Hertzer KM, Hines OJ, Rozengurt E, Eibl G. Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA- and EP1/Ca2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1. Am J Physiol Cell Physiol. 2015 Nov 15; 309(10):C639-49. PMID: 26310818.
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    6. Gifford E, Galante J, Kaji AH, Nguyen V, Nelson MT, Sidwell RA, Hartranft T, Jarman B, Melcher M, Reeves M, Reid C, Jacobsen GR, Thompson J, Are C, Smith B, Arnell T, Hines OJ, de Virgilio C. Factors associated with general surgery residents' desire to leave residency programs: a multi-institutional study. JAMA Surg. 2014 Sep; 149(9):948-53. PMID: 25075473.
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    7. Hines OJ. 2014 Society of University Surgeons presidential address. Surgery. 2014 Aug; 156(2):205-13. PMID: 24957672.
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    8. Toste PA, Kadera BE, Tatishchev SF, Dawson DW, Clerkin BM, Muthusamy R, Watson R, Tomlinson JS, Hines OJ, Reber HA, Donahue TR. Nonfunctional pancreatic neuroendocrine tumors <2 cm on preoperative imaging are associated with a low incidence of nodal metastasis and an excellent overall survival. J Gastrointest Surg. 2013 Dec; 17(12):2105-13. PMID: 24101447.
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    9. Takahashi H, Chen MC, Pham H, Matsuo Y, Ishiguro H, Reber HA, Takeyama H, Hines OJ, Eibl G. Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic cancer cells. Biochim Biophys Acta. 2013 Dec; 1833(12):2980-2987. PMID: 23954445.
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    10. Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev Res (Phila). 2013 Oct; 6(10):1064-73. PMID: 23943783.
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    11. Donald GW, Sunjaya D, Lu X, Chen F, Clerkin B, Eibl G, Li G, Tomlinson JS, Donahue TR, Reber HA, Hines OJ. Perioperative antibiotics for surgical site infection in pancreaticoduodenectomy: does the SCIP-approved regimen provide adequate coverage? Surgery. 2013 Aug; 154(2):190-6. PMID: 23664266.
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    12. Angst E, Park JL, Moro A, Lu QY, Lu X, Li G, King J, Chen M, Reber HA, Go VL, Eibl G, Hines OJ. The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo. Pancreas. 2013 Mar; 42(2):223-9. PMID: 23000892.
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    13. Pham H, Chen M, Takahashi H, King J, Reber HA, Hines OJ, Pandol S, Eibl G. Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells. Pancreas. 2012 Nov; 41(8):1306-15. PMID: 22889981.
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    14. Takahashi H, Chen MC, Pham H, Angst E, King JC, Park J, Brovman EY, Ishiguro H, Harris DM, Reber HA, Hines OJ, Gukovskaya AS, Go VL, Eibl G. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Biochim Biophys Acta. 2011 Aug; 1813(8):1465-74. PMID: 21596068.
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    15. Takahashi H, Li A, Dawson DW, Hines OJ, Reber HA, Eibl G. Cyclooxygenase-2 confers growth advantage to syngeneic pancreatic cancer cells. Pancreas. 2011 Apr; 40(3):453-9. PMID: 21343834.
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    16. Li A, Cheng XJ, Moro A, Singh RK, Hines OJ, Eibl G. CXCR2-Dependent Endothelial Progenitor Cell Mobilization in Pancreatic Cancer Growth. Transl Oncol. 2011 Feb 01; 4(1):20-8. PMID: 21286374.
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    17. Assifi MM, Hines OJ. Impact of duct-to-mucosa pancreaticojejunostomy with external drainage of the pancreatic duct after pancreaticoduodenectomy. J Surg Res. 2011 Dec; 171(2):457-8. PMID: 21227462.
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    18. Hines OJ. Minimally invasive approaches to infected pancreatic collections. Arch Surg. 2010 Sep; 145(9):825. PMID: 20873002.
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    19. Wasif N, Bentrem DJ, Farrell JJ, Ko CY, Hines OJ, Reber HA, Tomlinson JS. Invasive intraductal papillary mucinous neoplasm versus sporadic pancreatic adenocarcinoma: a stage-matched comparison of outcomes. Cancer. 2010 Jul 15; 116(14):3369-77. PMID: 20564064.
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    20. Angst E, Dawson DW, Nguyen A, Park J, Go VL, Reber HA, Hines OJ, Eibl G. Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. Pancreas. 2010 Jul; 39(5):675-9. PMID: 20173668.
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    21. Wasif N, Ko CY, Farrell J, Wainberg Z, Hines OJ, Reber H, Tomlinson JS. Impact of tumor grade on prognosis in pancreatic cancer: should we include grade in AJCC staging? Ann Surg Oncol. 2010 Sep; 17(9):2312-20. PMID: 20422460.
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    22. Hines OJ. Howard A. Reber, M.D., Distinguished Professor of Surgery, UCLA School of Medicine. Langenbecks Arch Surg. 2010 Jun; 395(5):593-4. PMID: 20383522.
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    23. Manuyakorn A, Paulus R, Farrell J, Dawson NA, Tze S, Cheung-Lau G, Hines OJ, Reber H, Seligson DB, Horvath S, Kurdistani SK, Guha C, Dawson DW. Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. J Clin Oncol. 2010 Mar 10; 28(8):1358-65. PMID: 20142597.
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    24. Hines OJ, Reber HA. Pancreatic surgery. Curr Opin Gastroenterol. 2009 Sep; 25(5):460-5. PMID: 19550315.
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    25. Büchler P, Reber HA, Tomlinson JS, Hankinson O, Kallifatidis G, Friess H, Herr I, Hines OJ. Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer. Neoplasia. 2009 Feb; 11(2):196-206. PMID: 19177204.
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    26. Yermilov I, Jain S, Sekeris E, Bentrem DJ, Hines OJ, Reber HA, Ko CY, Tomlinson JS. Utilization of parenteral nutrition following pancreaticoduodenectomy: is routine jejunostomy tube placement warranted? Dig Dis Sci. 2009 Jul; 54(7):1582-8. PMID: 18958617.
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    27. Hines OJ, Reber HA. Pancreatic surgery. Curr Opin Gastroenterol. 2008 Sep; 24(5):603-11. PMID: 19122502.
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    28. Hasan S, Satake M, Dawson DW, Funahashi H, Angst E, Go VL, Reber HA, Hines OJ, Eibl G. Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. Pancreas. 2008 Aug; 37(2):121-7. PMID: 18665070.
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    29. Tang RS, Weinberg B, Dawson DW, Reber H, Hines OJ, Tomlinson JS, Chaudhari V, Raman S, Farrell JJ. Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm. Clin Gastroenterol Hepatol. 2008 Jul; 6(7):815-9; quiz 719. PMID: 18602036.
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    30. Angst E, Reber HA, Hines OJ, Eibl G. Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2. Surgery. 2008 Jul; 144(1):57-65. PMID: 18571585.
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    31. Funahashi H, Satake M, Hasan S, Sawai H, Newman RA, Reber HA, Hines OJ, Eibl G. Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth. Pancreas. 2008 May; 36(4):353-62. PMID: 18437081.
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    32. Funahashi H, Satake M, Dawson D, Huynh NA, Reber HA, Hines OJ, Eibl G. Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. Cancer Res. 2007 Aug 01; 67(15):7068-71. PMID: 17652141.
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    33. Büchler P, Reber HA, Roth MM, Shiroishi M, Friess H, Hines OJ. Target therapy using a small molecule inhibitor against angiogenic receptors in pancreatic cancer. Neoplasia. 2007 Feb; 9(2):119-27. PMID: 17356708.
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    34. Su Y, Büchler P, Gazdhar A, Giese N, Reber HA, Hines OJ, Giese T, Büchler MW, Friess H. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. J Gastrointest Surg. 2006 Nov; 10(9):1230-41; discussion 1242. PMID: 17114010.
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    35. Hines OJ, Reber HA. Pancreatic surgery. Curr Opin Gastroenterol. 2006 Sep; 22(5):520-6. PMID: 16891883.
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    36. Satake M, Sawai H, Go VL, Satake K, Reber HA, Hines OJ, Eibl G. Estrogen receptors in pancreatic tumors. Pancreas. 2006 Aug; 33(2):119-27. PMID: 16868476.
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    37. Kazanjian KK, Reber HA, Hines OJ. Resection of pancreatic neuroendocrine tumors: results of 70 cases. Arch Surg. 2006 Aug; 141(8):765-9; discussion 769-70. PMID: 16924083.
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    38. Umetani N, Kim J, Hiramatsu S, Reber HA, Hines OJ, Bilchik AJ, Hoon DS. Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeats. Clin Chem. 2006 Jun; 52(6):1062-9. PMID: 16723681.
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    39. Kim J, Reber HA, Hines OJ, Kazanjian KK, Tran A, Ye X, Amersi FF, Martinez SR, Dry SM, Bilchik AJ, Hoon DS. The clinical significance of MAGEA3 expression in pancreatic cancer. Int J Cancer. 2006 May 01; 118(9):2269-75. PMID: 16331618.
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    40. Sawai H, Liu J, Reber HA, Hines OJ, Eibl G. Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. Mol Cancer Res. 2006 Mar; 4(3):159-67. PMID: 16547153.
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    41. Wente MN, Keane MP, Burdick MD, Friess H, Büchler MW, Ceyhan GO, Reber HA, Strieter RM, Hines OJ. Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis. Cancer Lett. 2006 Sep 28; 241(2):221-7. PMID: 16458421.
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    42. Hines OJ, Reber HA. Technique of pancreaticojejunostomy reconstruction after pancreaticoduodenectomy. J Hepatobiliary Pancreat Surg. 2006; 13(3):185-9. PMID: 16708292.
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    43. Sawai H, Okada Y, Kazanjian K, Kim J, Hasan S, Hines OJ, Reber HA, Hoon DS, Eibl G. The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling. Cancer Res. 2005 Dec 15; 65(24):11536-44. PMID: 16357163.
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    44. Wente MN, Eibl G, Reber HA, Friess H, Büchler MW, Hines OJ. The proteasome inhibitor MG132 induces apoptosis in human pancreatic cancer cells. Oncol Rep. 2005 Dec; 14(6):1635-8. PMID: 16273269.
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    45. Büchler P, Gazdhar A, Schubert M, Giese N, Reber HA, Hines OJ, Giese T, Ceyhan GO, Müller M, Büchler MW, Friess H. The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg. 2005 Dec; 242(6):791-800, discussion 800-1. PMID: 16327489.
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    46. Büchler P, Reber HA, Eibl G, Roth MA, Büchler MW, Friess H, Isacoff WH, Hines OJ. Combination therapy for advanced pancreatic cancer using Herceptin plus chemotherapy. Int J Oncol. 2005 Oct; 27(4):1125-30. PMID: 16142331.
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    47. Kazanjian KK, Hines OJ, Eibl G, Reber HA. Management of pancreatic fistulas after pancreaticoduodenectomy: results in 437 consecutive patients. Arch Surg. 2005 Sep; 140(9):849-54; discussion 854-6. PMID: 16172293.
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    48. Hines OJ, Reber HA. Pancreatic surgery. Curr Opin Gastroenterol. 2005 Sep; 21(5):568-72. PMID: 16093771.
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    49. Wente MN, Jain A, Kono E, Berberat PO, Giese T, Reber HA, Friess H, Büchler MW, Reiter RE, Hines OJ. Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer. Pancreas. 2005 Aug; 31(2):119-25. PMID: 16024997.
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    50. Guha S, Eibl G, Kisfalvi K, Fan RS, Burdick M, Reber H, Hines OJ, Strieter R, Rozengurt E. Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res. 2005 Apr 01; 65(7):2738-45. PMID: 15805273.
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    51. Eibl G, Takata Y, Boros LG, Liu J, Okada Y, Reber HA, Hines OJ. Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor. Cancer Res. 2005 Feb 01; 65(3):982-90. PMID: 15705899.
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    52. Targownik LE, Spiegel BM, Sack J, Hines OJ, Dulai GS, Gralnek IM, Farrell JJ. Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysis. Gastrointest Endosc. 2004 Dec; 60(6):865-74. PMID: 15604999.
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    53. Eibl G, Reber HA, Hines OJ, Go VL. COX and PPAR: possible interactions in pancreatic cancer. Pancreas. 2004 Nov; 29(4):247-53. PMID: 15502639.
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    54. Kazanjian KK, Reber HA, Hines OJ. Laparoscopic gastrojejunostomy for gastric outlet obstruction in pancreatic cancer. Am Surg. 2004 Oct; 70(10):910-3. PMID: 15529849.
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    55. Hines OJ, Reber HA. Pancreatic neoplasms. Curr Opin Gastroenterol. 2004 Sep; 20(5):452-8. PMID: 15689678.
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    56. Büchler P, Reber HA, Lavey RS, Tomlinson J, Büchler MW, Friess H, Hines OJ. Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model. J Surg Res. 2004 Aug; 120(2):295-303. PMID: 15234226.
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    57. Okada Y, Eibl G, Guha S, Duffy JP, Reber HA, Hines OJ. Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells. Clin Exp Metastasis. 2004; 21(4):285-92. PMID: 15554384.
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    58. Büchler P, Reber HA, Büchler MW, Friess H, Lavey RS, Hines OJ. Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression. Cancer. 2004 Jan 01; 100(1):201-10. PMID: 14692041.
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    59. Büchler P, Reber HA, Ullrich A, Shiroiki M, Roth M, Büchler MW, Lavey RS, Friess H, Hines OJ. Pancreatic cancer growth is inhibited by blockade of VEGF-RII. Surgery. 2003 Nov; 134(5):772-82. PMID: 14639356.
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    60. Duffy JP, Maggard M, Hiyama DT, Atkinson JB, McFadden DW, Ko CY, Hines OJ. Laparoscopic Nissen fundoplication improves quality of life in patients with atypical symptoms of gastroesophageal reflux. Am Surg. 2003 Oct; 69(10):833-8. PMID: 14570358.
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    61. Duffy JP, Hines OJ, Liu JH, Ko CY, Cortina G, Isacoff WH, Nguyen H, Leonardi M, Tompkins RK, Reber HA. Improved survival for adenocarcinoma of the ampulla of Vater: fifty-five consecutive resections. Arch Surg. 2003 Sep; 138(9):941-8; discussion 948-50. PMID: 12963649.
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    62. Okada Y, Eibl G, Duffy JP, Reber HA, Hines OJ. Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer. Surgery. 2003 Aug; 134(2):293-9. PMID: 12947332.
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    63. Eibl G, Bruemmer D, Okada Y, Duffy JP, Law RE, Reber HA, Hines OJ. PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. Biochem Biophys Res Commun. 2003 Jul 11; 306(4):887-97. PMID: 12821125.
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    64. Büchler P, Gukovskaya AS, Mouria M, Büchler MC, Büchler MW, Friess H, Pandol SJ, Reber HA, Hines OJ. Prevention of metastatic pancreatic cancer growth in vivo by induction of apoptosis with genistein, a naturally occurring isoflavonoid. Pancreas. 2003 Apr; 26(3):264-73. PMID: 12657953.
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    65. Duffy JP, Eibl G, Reber HA, Hines OJ. Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer. Mol Cancer. 2003 Jan 22; 2:12. PMID: 12605718.
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    66. Büchler P, Reber HA, Büchler M, Shrinkante S, Büchler MW, Friess H, Semenza GL, Hines OJ. Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer. Pancreas. 2003 Jan; 26(1):56-64. PMID: 12499918.
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    67. Eibl G, Reber HA, Wente MN, Hines OJ. The selective cyclooxygenase-2 inhibitor nimesulide induces apoptosis in pancreatic cancer cells independent of COX-2. Pancreas. 2003 Jan; 26(1):33-41. PMID: 12499915.
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    68. Büchler P, Reber HA, Büchler MW, Friess H, Hines OJ. VEGF-RII influences the prognosis of pancreatic cancer. Ann Surg. 2002 Dec; 236(6):738-49; discussion 749. PMID: 12454512.
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    69. Yoon DY, Chu J, Chandler C, Hiyama S, Thompson JE, Hines OJ. Human cytokine levels in nonperforated versus perforated appendicitis: molecular serum markers for extent of disease? Am Surg. 2002 Dec; 68(12):1033-7. PMID: 12516803.
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    70. Mouria M, Gukovskaya AS, Jung Y, Buechler P, Hines OJ, Reber HA, Pandol SJ. Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int J Cancer. 2002 Apr 10; 98(5):761-9. PMID: 11920648.
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    71. Towfigh S, Chandler C, Hines OJ, McFadden DW. Outcomes from peptic ulcer surgery have not benefited from advances in medical therapy. Am Surg. 2002 Apr; 68(4):385-9. PMID: 11952253.
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    72. Hines OJ, Ryder N, Chu J, McFadden D. Lysophosphatidic acid stimulates intestinal restitution via cytoskeletal activation and remodeling. J Surg Res. 2000 Jul; 92(1):23-8. PMID: 10864477.
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