Oliver Hankinson

Title(s)Recalled Professor, Pathology and Laboratory Medicine
SchoolMedicine
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    Title(s)Professor Emeritus, Pathology and Laboratory Medicine


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    A CRISPR-Cas9 screen for novel proteins required for induction of CYP1A1 by AHR
    NIH R21ES026392Jun 1, 2016 - May 31, 2019
    Role: Principal Investigator
    TCDD inductions of omega-6 and omega-3 PUFA metabolism act inversely on tumor progression
    NIH R01ES024434Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Training in Molecular Toxicology
    NIH T32ES015457Jul 1, 2007 - Jun 30, 2026
    Role: Principal Investigator
    Function and Regulation of Human Cytochrome P4502S1
    NIH R01ES015384Sep 28, 2006 - Jul 31, 2013
    Role: Principal Investigator
    ARNT:Roles in Tumor Induction and Growth, and Toxicity.
    NIH R01CA093471Dec 15, 2001 - Nov 30, 2006
    Role: Principal Investigator
    ARNT PROTEIN, DEVELOPMENT AND CARCINOGENESIS
    NIH R01ES006439Apr 1, 1995 - Mar 31, 1999
    Role: Principal Investigator
    Carcinogen Activation and Screening in Variant Cells
    NIH R01CA028868Apr 1, 1980 - Nov 30, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. An aryl hydrocarbon receptor agonist suppresses the growth of human umbilical vein endothelial cells in vitro: Potent effect with polyunsaturated fatty acids. Int J Exp Pathol. 2020 12; 101(6):248-263. Yamaguchi M, Hankinson O. PMID: 32985761; PMCID: PMC7691222.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    2. Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression. Sci Rep. 2020 05 12; 10(1):7843. Huerta-Yepez S, Tirado-Rodriguez A, Montecillo-Aguado MR, Yang J, Hammock BD, Hankinson O. PMID: 32398692; PMCID: PMC7217871.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    3. A CRISPR/Cas9 Whole-Genome Screen Identifies Genes Required for Aryl Hydrocarbon Receptor-Dependent Induction of Functional CYP1A1. Toxicol Sci. 2019 08 01; 170(2):310-319. Sundberg CD, Hankinson O. PMID: 31086989; PMCID: PMC6657581.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    4. 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin suppresses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling. Int J Oncol. 2019 04; 54(4):1422-1432. Yamaguchi M, Hankinson O. PMID: 30720065; PMCID: PMC6411353.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    5. Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro. Int J Oncol. 2019 01; 54(1):188-198. Yamaguchi M, Osuka S, Hankinson O, Murata T. PMID: 30387835; PMCID: PMC8353224.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    6. 2,3,7,8‑Tetrachlorodibenzo‑p‑dioxin suppresses the growth of human liver cancer HepG2 cells in vitro: Involvement of cell signaling factors. Int J Oncol. 2018 Oct; 53(4):1657-1666. Yamaguchi M, Hankinson O. PMID: 30066859; PMCID: PMC6086623.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    7. ChIP-re-ChIP: Co-occupancy Analysis by Sequential Chromatin Immunoprecipitation. Methods Mol Biol. 2018; 1689:103-112. Beischlag TV, Prefontaine GG, Hankinson O. PMID: 29027168.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    8. Role of diets rich in omega-3 and omega-6 in the development of cancer. Bol Med Hosp Infant Mex. 2016 Nov - Dec; 73(6):446-456. Huerta-Yépez S, Tirado-Rodriguez AB, Hankinson O. PMID: 29421289.
      View in: PubMed   Mentions: 34     Fields:    
    9. The role of AHR-inducible cytochrome P450s in metabolism of polyunsaturated fatty acids. Drug Metab Rev. 2016 08; 48(3):342-50. Hankinson O. PMID: 27358009; PMCID: PMC5026385.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    10. SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor. J Biol Chem. 2014 Nov 28; 289(48):33655-62. Solaimani P, Wang F, Hankinson O. PMID: 25305016; PMCID: PMC4246116.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    11. Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2013 Nov; 136(1):107-19. Solaimani P, Damoiseaux R, Hankinson O. PMID: 23997114; PMCID: PMC3829574.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    12. Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport. Drug Metab Dispos. 2013 Oct; 41(10):1725-31. Ingelman-Sundberg M, Zhong XB, Hankinson O, Beedanagari S, Yu AM, Peng L, Osawa Y. PMID: 23918665; PMCID: PMC3781370.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    13. Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. J Toxicol Sci. 2013; 38(6):833-6. Yang J, Solaimani P, Dong H, Hammock B, Hankinson O. PMID: 24213002; PMCID: PMC4068614.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    14. HIF-1 expression is associated with CCL2 chemokine expression in airway inflammatory cells: implications in allergic airway inflammation. Respir Res. 2012 Jul 23; 13:60. Baay-Guzman GJ, Bebenek IG, Zeidler M, Hernandez-Pando R, Vega MI, Garcia-Zepeda EA, Antonio-Andres G, Bonavida B, Riedl M, Kleerup E, Tashkin DP, Hankinson O, Huerta-Yepez S. PMID: 22823210; PMCID: PMC3439306.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    15. The transcription factor encyclopedia. Genome Biol. 2012; 13(3):R24. Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. PMID: 22458515; PMCID: PMC3439975.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    16. 2,3,7,8-Tetrachlorodibenzo-p-dioxin treatment alters eicosanoid levels in several organs of the mouse in an aryl hydrocarbon receptor-dependent fashion. Toxicol Appl Pharmacol. 2012 Mar 01; 259(2):143-51. Bui P, Solaimani P, Wu X, Hankinson O. PMID: 22230337; PMCID: PMC3288243.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    17. CYP2S1 is negatively regulated by corticosteroids in human cell lines. Toxicol Lett. 2012 Feb 25; 209(1):30-4. Bebenek IG, Solaimani P, Bui P, Hankinson O. PMID: 22155357.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis. Allergy. 2011 Jul; 66(7):909-18. Huerta-Yepez S, Baay-Guzman GJ, Bebenek IG, Hernandez-Pando R, Vega MI, Chi L, Riedl M, Diaz-Sanchez D, Kleerup E, Tashkin DP, Gonzalez FJ, Bonavida B, Zeidler M, Hankinson O. PMID: 21517900; PMCID: PMC3107385.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    19. Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. Eur J Pharmacol. 2011 May 20; 659(1):30-6. Quesada A, Bui PH, Homanics GE, Hankinson O, Handforth A. PMID: 21256842; PMCID: PMC3988263.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    20. Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids. Drug Metab Dispos. 2011 Feb; 39(2):180-90. Bui P, Imaizumi S, Beedanagari SR, Reddy ST, Hankinson O. PMID: 21068195; PMCID: PMC3033693.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    21. Role of epigenetic mechanisms in differential regulation of the dioxin-inducible human CYP1A1 and CYP1B1 genes. Mol Pharmacol. 2010 Oct; 78(4):608-16. Beedanagari SR, Taylor RT, Bui P, Wang F, Nickerson DW, Hankinson O. PMID: 20631054; PMCID: PMC2981391.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    22. Roles of coactivators in hypoxic induction of the erythropoietin gene. PLoS One. 2010 Apr 02; 5(4):e10002. Wang F, Zhang R, Wu X, Hankinson O. PMID: 20368990; PMCID: PMC2848849.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    23. Aryl hydrocarbon nuclear translocator (hypoxia inducible factor 1beta) activity is required more during early than late tumor growth. Mol Carcinog. 2010 Feb; 49(2):157-65. Shi S, Yoon DY, Hodge-Bell K, Huerta-Yepez S, Hankinson O. PMID: 19824022; PMCID: PMC2938742.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines. Toxicol Lett. 2010 Apr 15; 194(1-2):26-33. Beedanagari SR, Taylor RT, Hankinson O. PMID: 20116417; PMCID: PMC2839003.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    25. The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene. Carcinogenesis. 2009 Nov; 30(11):1957-61. Shi S, Yoon DY, Hodge-Bell KC, Bebenek IG, Whitekus MJ, Zhang R, Cochran AJ, Huerta-Yepez S, Yim SH, Gonzalez FJ, Jaiswal AK, Hankinson O. PMID: 19755658; PMCID: PMC2791324.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    26. Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli. Mol Pharmacol. 2009 Nov; 76(5):1031-43. Bui PH, Hankinson O. PMID: 19713358; PMCID: PMC2774995.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    27. Fatty acid hydroperoxides support cytochrome P450 2S1-mediated bioactivation of benzo[a]pyrene-7,8-dihydrodiol. Mol Pharmacol. 2009 Nov; 76(5):1044-52. Bui PH, Hsu EL, Hankinson O. PMID: 19713357; PMCID: PMC2774993.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    28. Repression of aryl hydrocarbon receptor transcriptional activity by epidermal growth factor. Mol Interv. 2009 Jun; 9(3):116-8. Hankinson O. PMID: 19592671; PMCID: PMC3139379.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    29. Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes. Toxicol Sci. 2009 Jul; 110(1):61-7. Beedanagari SR, Bebenek I, Bui P, Hankinson O. PMID: 19376845; PMCID: PMC2696325.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    30. Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals. J Oncol. 2009; 2009:491985. Hsu EL, Chen N, Westbrook A, Wang F, Zhang R, Taylor RT, Hankinson O. PMID: 19325924; PMCID: PMC2659867.
      View in: PubMed   Mentions: 11  
    31. Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer. Neoplasia. 2009 Feb; 11(2):196-206. Büchler P, Reber HA, Tomlinson JS, Hankinson O, Kallifatidis G, Friess H, Herr I, Hines OJ. PMID: 19177204; PMCID: PMC2631144.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    32. Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells. Toxicol Sci. 2009 Jan; 107(1):1-8. Taylor RT, Wang F, Hsu EL, Hankinson O. PMID: 18842620; PMCID: PMC2638648.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    33. Why does ARNT2 behave differently from ARNT? Toxicol Sci. 2008 May; 103(1):1-3. Hankinson O. PMID: 18397918; PMCID: PMC2938178.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    34. The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil. Drug Metab Dispos. 2008 Jul; 36(7):1291-9. Bui PH, Quesada A, Handforth A, Hankinson O. PMID: 18411403; PMCID: PMC2927974.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    35. CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3'-diindolylmethane for breast and ovarian cancers. Cancer Lett. 2008 Jun 28; 265(1):113-23. Hsu EL, Chen N, Westbrook A, Wang F, Zhang R, Taylor RT, Hankinson O. PMID: 18378071.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    36. The effect of aromatic hydrocarbon receptor on the phenotype of the Hepa 1c1c7 murine hepatoma cells in the absence of dioxin. Gene Regul Syst Bio. 2007 Sep 18; 1:49-56. Wang F, Zhang R, Shi S, Hankinson O. PMID: 19936078; PMCID: PMC2759125.
      View in: PubMed   Mentions: 4  
    37. Inhibitory effects of nitric oxide on invasion of human cancer cells. Cancer Lett. 2007 Nov 18; 257(2):274-82. Wang F, Zhang R, Xia T, Hsu E, Cai Y, Gu Z, Hankinson O. PMID: 17869411; PMCID: PMC2763642.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    38. A proposed mechanism for the protective effect of dioxin against breast cancer. Toxicol Sci. 2007 Aug; 98(2):436-44. Hsu EL, Yoon D, Choi HH, Wang F, Taylor RT, Chen N, Zhang R, Hankinson O. PMID: 17517823.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    39. Identification of novel dioxin-responsive genes by representational difference analysis. Xenobiotica. 2007 Mar; 37(3):271-9. Rivera SP, Saarikoski ST, Sun W, Hankinson O. PMID: 17624025.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    40. A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia. J Biol Chem. 2007 Apr 13; 282(15):10881-93. Rivera SP, Wang F, Saarikoski ST, Taylor RT, Chapman B, Zhang R, Hankinson O. PMID: 17277313.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    41. Identifying target genes of the aryl hydrocarbon receptor nuclear translocator (Arnt) using DNA microarray analysis. Biol Chem. 2006 Sep; 387(9):1215-8. Wang F, Shi S, Zhang R, Hankinson O. PMID: 16972789.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    42. CYP2S1: a short review. Toxicol Appl Pharmacol. 2005 Sep 01; 207(2 Suppl):62-9. Saarikoski ST, Rivera SP, Hankinson O, Husgafvel-Pursiainen K. PMID: 16054184.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    43. Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes. Toxicology. 2005 Feb 28; 207(3):401-9. Rivera SP, Choi HH, Chapman B, Whitekus MJ, Terao M, Garattini E, Hankinson O. PMID: 15664268.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    44. Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor. Arch Biochem Biophys. 2005 Jan 15; 433(2):379-86. Hankinson O. PMID: 15581594.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    45. Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7. Chem Biol Interact. 2004 Nov 20; 150(2):161-70. Fretland AJ, Safe S, Hankinson O. PMID: 15535986.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    46. Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia. J Biol Chem. 2004 Dec 24; 279(52):54620-8. Beischlag TV, Taylor RT, Rose DW, Yoon D, Chen Y, Lee WH, Rosenfeld MG, Hankinson O. PMID: 15485806.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    47. Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. J Biol Chem. 2004 Nov 05; 279(45):46733-41. Wang F, Zhang R, Beischlag TV, Muchardt C, Yaniv M, Hankinson O. PMID: 15347669.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    48. Role of mediator in transcriptional activation by the aryl hydrocarbon receptor. J Biol Chem. 2004 Apr 02; 279(14):13593-600. Wang S, Ge K, Roeder RG, Hankinson O. PMID: 14729673.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    49. Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALADase activity. Cancer Res. 2003 May 15; 63(10):2645-8. Anilkumar G, Rajasekaran SA, Wang S, Hankinson O, Bander NH, Rajasekaran AK. PMID: 12750292.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    50. Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia. FEBS Lett. 2002 Oct 23; 530(1-3):186-90. Saarikoski ST, Rivera SP, Hankinson O. PMID: 12387890.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    51. Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Mol Cell Biol. 2002 Jun; 22(12):4319-33. Beischlag TV, Wang S, Rose DW, Torchia J, Reisz-Porszasz S, Muhammad K, Nelson WE, Probst MR, Rosenfeld MG, Hankinson O. PMID: 12024042; PMCID: PMC133867.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    52. Identification of a novel dioxin-inducible cytochrome P450. Mol Pharmacol. 2002 Feb; 61(2):255-9. Rivera SP, Saarikoski ST, Hankinson O. PMID: 11809848.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    53. Functional involvement of the Brahma/SWI2-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complex. J Biol Chem. 2002 Apr 05; 277(14):11821-7. Wang S, Hankinson O. PMID: 11805098.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    54. Identification of genes differentially induced by hypoxia in pancreatic cancer cells. Biochem Biophys Res Commun. 2001 Nov 09; 288(4):882-6. Yoon DY, Buchler P, Saarikoski ST, Hines OJ, Reber HA, Hankinson O. PMID: 11688991.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    55. Loss of cyp1a1 messenger rna expression due to nonsense-mediated decay. Mol Pharmacol. 2001 Aug; 60(2):388-93. Lei XD, Chapman B, Hankinson O. PMID: 11455027.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    56. CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor. Pharmacogenetics. 2001 Aug; 11(6):501-9. Anttila S, Tuominen P, Hirvonen A, Nurminen M, Karjalainen A, Hankinson O, Elovaara E. PMID: 11505220.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    57. Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol. Am J Respir Cell Mol Biol. 2001 Mar; 24(3):339-44. Roth MD, Marques-Magallanes JA, Yuan M, Sun W, Tashkin DP, Hankinson O. PMID: 11245634.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    58. Effect of diesel exhaust particles and their components on the allergen-specific IgE and IgG1 response in mice. Toxicology. 2001 Feb 28; 159(3):143-58. Heo Y, Saxon A, Hankinson O. PMID: 11223170.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    59. An uncommon phenotype of poor inducibility of CYP1A1 in human lung is not ascribable to polymorphisms in the AHR, ARNT, or CYP1A1 genes. Pharmacogenetics. 2000 Nov; 10(8):741-51. Anttila S, Lei XD, Elovaara E, Karjalainen A, Sun W, Vainio H, Hankinson O. PMID: 11186136.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    60. A mutation in the aryl hydrocarbon receptor (AHR) in a cultured mammalian cell line identifies a novel region of AHR that affects DNA binding. J Biol Chem. 1997 Dec 12; 272(50):31845-54. Sun W, Zhang J, Hankinson O. PMID: 9395531.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    61. ARNT-deficient mice and placental differentiation. Dev Biol. 1997 Nov 15; 191(2):297-305. Kozak KR, Abbott B, Hankinson O. PMID: 9398442.
      View in: PubMed   Mentions: 101     Fields:    Translation:Animals
    62. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8104-9. Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, Ratcliffe PJ. PMID: 9223322; PMCID: PMC21564.
      View in: PubMed   Mentions: 345     Fields:    Translation:AnimalsCells
    63. Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein. J Biol Chem. 1997 Feb 14; 272(7):4451-7. Probst MR, Fan CM, Tessier-Lavigne M, Hankinson O. PMID: 9020169.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    64. Induction of cytochrome P4501A1 by photooxidized tryptophan in Hepa lclc7 cells. Biochem Pharmacol. 1996 Dec 24; 52(12):1883-93. Sindhu RK, Reisz-Porszasz S, Hankinson O, Kikkawa Y. PMID: 8951347.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    65. Basis for the loss of aryl hydrocarbon receptor gene expression in clones of a mouse hepatoma cell line. Mol Pharmacol. 1996 Dec; 50(6):1454-62. Zhang J, Watson AJ, Probst MR, Minehart E, Hankinson O. PMID: 8967965.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    66. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J Biol Chem. 1996 Jun 21; 271(25):15117-23. Wood SM, Gleadle JM, Pugh CW, Hankinson O, Ratcliffe PJ. PMID: 8662957.
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    67. Functional characterization of DNA-binding domains of the subunits of the heterodimeric aryl hydrocarbon receptor complex imputing novel and canonical basic helix-loop-helix protein-DNA interactions. J Biol Chem. 1996 Apr 12; 271(15):8843-50. Bacsi SG, Hankinson O. PMID: 8621524.
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    68. Identification of a novel domain in the aryl hydrocarbon receptor required for DNA binding. J Biol Chem. 1996 Feb 16; 271(7):3743-9. Fukunaga BN, Hankinson O. PMID: 8631989.
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    69. Identification of functional domains of the aryl hydrocarbon receptor. J Biol Chem. 1995 Dec 08; 270(49):29270-8. Fukunaga BN, Probst MR, Reisz-Porszasz S, Hankinson O. PMID: 7493958.
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    70. Orientation of the heterodimeric aryl hydrocarbon (dioxin) receptor complex on its asymmetric DNA recognition sequence. Mol Pharmacol. 1995 Mar; 47(3):432-8. Bacsi SG, Reisz-Porszasz S, Hankinson O. PMID: 7700240.
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    71. Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT). Mol Cell Biol. 1994 Sep; 14(9):6075-86. Reisz-Porszasz S, Probst MR, Fukunaga BN, Hankinson O. PMID: 8065341; PMCID: PMC359134.
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    72. The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action. Trends Endocrinol Metab. 1994 Aug; 5(6):240-4. Hankinson O. PMID: 18407214.
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    73. A genetic analysis of processes regulating cytochrome P4501A1 expression. Adv Enzyme Regul. 1994; 34:159-71. Hankinson O. PMID: 7942273.
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    74. Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action. Mol Pharmacol. 1993 Sep; 44(3):511-8. Probst MR, Reisz-Porszasz S, Agbunag RV, Ong MS, Hankinson O. PMID: 8396713.
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    75. Research on the aryl hydrocarbon (dioxin) receptor is primed to take off. Arch Biochem Biophys. 1993 Jan; 300(1):1-5. Hankinson O. PMID: 8380960.
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    76. Investigation on the potential role of the Ah receptor nuclear translocator protein in vitamin D receptor action. J Recept Res. 1993; 13(8):1147-59. Reisz-Porszasz S, Reyes H, DeLuca HF, Prahl JM, Hankinson O. PMID: 8254580.
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    77. An MspI RFLP in the human ARNT gene, encoding a subunit of the nuclear form of the Ah (dioxin) receptor. Hum Mol Genet. 1992 Aug; 1(5):351. Johnson BS, Brooks BA, Reyes H, Hoffman EC, Hankinson O. PMID: 1284629.
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    78. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science. 1992 May 22; 256(5060):1193-5. Reyes H, Reisz-Porszasz S, Hankinson O. PMID: 1317062.
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    79. Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription. Mol Cell Biol. 1992 May; 12(5):2115-23. Watson AJ, Weir-Brown KI, Bannister RM, Chu FF, Reisz-Porszasz S, Fujii-Kuriyama Y, Sogawa K, Hankinson O. PMID: 1314949; PMCID: PMC364383.
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    80. Dioxin- and Ah receptor-dependent protein binding to xenobiotic responsive elements and G-rich DNA studied by in vivo footprinting. J Biol Chem. 1992 Apr 05; 267(10):6874-8. Watson AJ, Hankinson O. PMID: 1313025.
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    81. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science. 1991 May 17; 252(5008):954-8. Hoffman EC, Reyes H, Chu FF, Sander F, Conley LH, Brooks BA, Hankinson O. PMID: 1852076.
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    82. Genetic and molecular analysis of the Ah receptor and of Cyp1a1 gene expression. Biochimie. 1991 Jan; 73(1):61-6. Hankinson O, Brooks BA, Weir-Brown KI, Hoffman EC, Johnson BS, Nanthur J, Reyes H, Watson AJ. PMID: 1851644.
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    83. Selections for and against cells possessing cytochrome P450IA1-dependent aryl hydrocarbon hydroxylase activity. Methods Enzymol. 1991; 206:381-400. Hankinson O. PMID: 1784225.
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    84. DNA transfection of a gene repressing aryl hydrocarbon hydroxylase induction. Carcinogenesis. 1988 Sep; 9(9):1581-6. Watson AJ, Hankinson O. PMID: 3409461.
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    85. A third genetic locus affecting the Ah (dioxin) receptor. J Biol Chem. 1988 Jul 25; 263(21):10111-7. Karenlampi SO, Legraverend C, Gudas JM, Carramanzana N, Hankinson O. PMID: 2839475.
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    86. Regulation of cytochrome P-450c in differentiated and dedifferentiated rat hepatoma cells: role of the Ah receptor. Somat Cell Mol Genet. 1987 Sep; 13(5):513-28. Gudas JM, Hankinson O. PMID: 2821631.
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    87. Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast. EMBO J. 1987 Jul; 6(7):1929-33. Kimura S, Smith HH, Hankinson O, Nebert DW. PMID: 3308449; PMCID: PMC553578.
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    88. Intracellular location of the Ah receptor. J Cell Physiol. 1986 Sep; 128(3):441-8. Gudas JM, Karenlampi SO, Hankinson O. PMID: 3018003.
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    89. Reversible inactivation of the Ah receptor associated with changes in intracellular ATP levels. J Cell Physiol. 1986 Sep; 128(3):449-56. Gudas JM, Hankinson O. PMID: 3018004.
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    90. DNA-mediated restoration of aryl hydrocarbon hydroxylase induction in a mouse hepatoma mutant defective in nuclear translocation of the Ah receptor. Arch Toxicol Suppl. 1986; 9:159-62. Kärenlampi SO, Montisano DF, Gudas JM, Hankinson O. PMID: 3028324.
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    91. Transfection by genomic DNA of cytochrome P1-450 enzymatic activity and inducibility. Mol Cell Biol. 1985 Apr; 5(4):698-704. Montisano DF, Hankinson O. PMID: 3990691; PMCID: PMC366772.
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    92. Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line. J Biol Chem. 1985 Feb 10; 260(3):1790-5. Hankinson O, Andersen RD, Birren BW, Sander F, Negishi M, Nebert DW. PMID: 3968086.
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    93. Isolation and characterization of revertants from four different classes of aryl hydrocarbon hydroxylase-deficient hepa-1 mutants. Mol Cell Biol. 1984 Aug; 4(8):1597-604. Van Gurp JR, Hankinson O. PMID: 6493230; PMCID: PMC368953.
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    94. The Ah receptor: binding specificity only for foreign chemicals? Biochem Pharmacol. 1984 Mar 15; 33(6):917-24. Nebert DW, Eisen HJ, Hankinson O. PMID: 6324804.
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    95. Single-step phototoxic selection procedure for isolating cells that possess aryl hydrocarbon hydroxylase. Cancer Res. 1983 Dec; 43(12 Pt 1):6031-8. Van Gurp JR, Hankinson O. PMID: 6640544.
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    96. The defects in all classes of aryl hydrocarbon hydroxylase-deficient mutant of mouse hepatoma line, Hepa-1, are restricted to activities catalyzed by cytochrome P-450. Cancer Lett. 1983 Oct; 20(3):249-54. Duthu GS, Hankinson O. PMID: 6627226.
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    97. Effects of cytochrome P1-450 inducers on the cell-surface receptors for epidermal growth factor, phorbol 12,13-dibutyrate, or insulin of cultured mouse hepatoma cells. J Biol Chem. 1983 Sep 10; 258(17):10378-83. Kärenlampi SO, Eisen HJ, Hankinson O, Nebert DW. PMID: 6309801.
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    98. Dominant and recessive aryl hydrocarbon hydroxylase-deficient mutants of mouse hepatoma line, Hepa-1, and assignment of recessive mutants to three complementation groups. Somatic Cell Genet. 1983 Jul; 9(4):497-514. Hankinson O. PMID: 6623311.
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    99. Characterization of NADPH-cytochrome P-450 reductase in a mouse hepatoma cell line. Cancer Lett. 1983 Apr; 18(3):237-43. Duthu GS, Nestor MS, Berliner JA, Philpot RM, Hankinson O. PMID: 6303557.
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    100. Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones. J Biol Chem. 1982 Jun 10; 257(11):6402-7. Legraverend C, Hannah RR, Eisen HJ, Owens IS, Nebert DW, Hankinson O. PMID: 6896205.
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    101. Evidence that Benzo(a) pyrene-resistant, aryl hydrocarbon hydroxylase-deficient variants of mouse hepatoma line, Hepa-1, are mutational in origin. Somatic Cell Genet. 1981 Jul; 7(4):373-88. Hankinson O. PMID: 6269236.
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    102. Unstable aryl hydrocarbon hydroxylase-deficient variants of a rat hepatoma line. Somatic Cell Genet. 1980 Nov; 6(6):751-67. Hankinson O. PMID: 7444721.
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    103. Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase. Proc Natl Acad Sci U S A. 1979 Jan; 76(1):373-6. Hankinson O. PMID: 106390; PMCID: PMC382941.
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