Michael D Roth

Title(s)Professor, Medicine
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    Collapse Biography 
    Collapse Education and Training
    UCLA School of Medicine , Los Angeles06/1989Pulmonary & Critical Care Fellowship
    UCLA School of Medicine, Los Angeles06/1986Internal Medicine Residency
    UCLA School of Medicine, Los AngelesMD06/1983Medicine
    UC Irvine, IrvineBS06/1979Biological Sciences

    Collapse Overview 
    Collapse Overview
    Michael D. Roth, M.D., is a Professor of Medicine in the Division of Pulmonary and Critical Care, a member of the Interdepartmental Program in Molecular Toxicology, and serves as a Vice-Chairman for the Department of Medicine overseeing Research Compliance

    Dr. Roth graduated with Summa Cum Laude and Phi Beta Kappa honors in Biological Sciences from U.C. Irvine in 1979 and completed his M.D. at the UCLA School of Medicine in 1983, graduating with AOA honors. He also completed his specialty training at UCLA Medical Center with Board-certification in Internal Medicine, Pulmonary Medicine & Critical Care.

    As a full-time faculty at the David Geffen School of Medicine, Dr. Roth is actively involved in teaching, research, administration and patient care. He is recognized nationally for his work in the fields of cancer research, applied immunology, developing new therapies for the treatment of emphysema and scleroderma-related interstitial lung disease, and for his work on the toxicology of inhaled substance abuse. He is a member of the American Thoracic Society, American College of Chest Physicians, Association for Cancer Research, American Association for Immunologists, Society for Immunotherapy of Cancer, and the Jonsson Cancer Center/UCLA.

    In addition to research and teaching, Dr. Roth sees patients with Pulmonary and Critical Care conditions at the Ronald Reagan-UCLA Medical Center and in the outpatient Pulmonary Clinic located in the 200 Medical Plaza Bldg.

    Specific areas of clinic interest include chronic cough, bronchiectasis, COPD with emphysema, asthma, lung nodules, and connective tissue diseases that involve the lung.

    Collapse Research 
    Collapse Research Activities and Funding
    Impact of Cannabis Potency on the Properties, Composition, and Toxicity of Inhaled and Second-Hand Smoke
    California Department of Consumer Affairs; Bureau of Cannabis Contro 65309Sep 8, 2021 - Sep 4, 2023
    Role: Principal Investigator
    Linking E-Cigarette Aerosol Characteristics to Mechanisms of Pulmonary Toxicity
    NIH/NHLBI R01 HL139379Sep 1, 2018 - Aug 31, 2022
    Role: Co-Investigator
    Scleroderma Lung Study III: Combining of anti-fibrotic effects of Pirfenidone with Mycophenolate to treat scleroderma-related interstitial lung disease
    Genentech, Inc C4-200420Jul 1, 2017 - Sep 30, 2022
    Role: Principal Investigator and IND Sponsor
    Marijuana smoke promotes dysfunctional macrophage responses to HIV and pneumonia
    NIH R01DA037102May 15, 2014 - Dec 31, 2020
    Role: Principal Investigator
    NIH R01AR055075Sep 19, 2006 - Aug 31, 2012
    Role: Principal Investigator
    Vector-based Generation of Monoclonal Antibodies against the CB2 Receptor
    NIH R21DA021813Sep 1, 2006 - Jun 30, 2010
    Role: Principal Investigator
    Adjuvant immunotherapy for non-small cell lung cancer
    NIH R21CA110494Aug 16, 2004 - Jul 31, 2007
    Role: Principal Investigator
    NIH/NHLBI N01HR096143Oct 12, 1999 - Sep 29, 2002
    Role: Principal Investigator
    Cocaine Smoking Effects on Lung Immunity &Host Defense
    NIH R01DA008254Jun 1, 1993 - Aug 31, 2007
    Role: Principal Investigator
    NIH K08CA001549Sep 30, 1990 - Sep 29, 1993
    Role: Principal Investigator
    Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral Immunity
    NIH R01DA003018Jul 1, 1982 - Apr 30, 2012
    Role: Principal Investigator
    NIH R37DA003018Jul 1, 1982 - Sep 29, 2006
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Combining Clinical and Biological Data to Predict Progressive Pulmonary Fibrosis in Patients With Systemic Sclerosis Despite Immunomodulatory Therapy. ACR Open Rheumatol. 2023 Oct; 5(10):547-555. Volkmann ER, Wilhalme H, Assassi S, Kim GHJ, Goldin J, Kuwana M, Tashkin DP, Roth MD. PMID: 37592449; PMCID: PMC10570669.
      View in: PubMed   Mentions: 2  
    2. Association of Symptoms of Gastroesophageal Reflux, Esophageal Dilation, and Progression of Systemic Sclerosis-Related Interstitial Lung Disease. Arthritis Care Res (Hoboken). 2023 08; 75(8):1690-1697. Volkmann ER, Tashkin DP, Leng M, Kim GHJ, Goldin J, Roth MD. PMID: 36504432; PMCID: PMC10258217.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Blood Neutrophil Count and Neutrophil-to-Lymphocyte Ratio for Prediction of Disease Progression and Mortality in Two Independent Systemic Sclerosis Cohorts. Arthritis Care Res (Hoboken). 2023 03; 75(3):648-656. Wareing N, Mohan V, Taherian R, Volkmann ER, Lyons MA, Wilhalme H, Roth MD, Estrada-Y-Martin RM, Skaug B, Mayes MD, Tashkin DP, Assassi S. PMID: 35287250; PMCID: PMC9470772.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    4. Sex differences in clinical outcomes and biological profiles in systemic sclerosis-associated interstitial lung disease: a post-hoc analysis of two randomised controlled trials. Lancet Rheumatol. 2022 Oct; 4(10):e668-e678. Volkmann ER, Tashkin DP, Silver R, Bostwick CF, Assassi S, Frost DB, Leng M, Wilhalme H, Kim GH, Goldin J, Roth MD. PMID: 37745675; PMCID: PMC10518185.
      View in: PubMed   Mentions: 4  
    5. Hyaluronidase Enhances Targeting of Hydrogel-Encapsulated Anti-CTLA-4 to Tumor Draining Lymph Nodes and Improves Anti-Tumor Efficacy. Gels. 2022 May 03; 8(5). Harui A, Roth MD. PMID: 35621582; PMCID: PMC9141760.
      View in: PubMed   Mentions: 2  
    6. Early Outpatient Treatment for Covid-19 with Convalescent Plasma. N Engl J Med. 2022 05 05; 386(18):1700-1711. Sullivan DJ, Gebo KA, Shoham S, Bloch EM, Lau B, Shenoy AG, Mosnaim GS, Gniadek TJ, Fukuta Y, Patel B, Heath SL, Levine AC, Meisenberg BR, Spivak ES, Anjan S, Huaman MA, Blair JE, Currier JS, Paxton JH, Gerber JM, Petrini JR, Broderick PB, Rausch W, Cordisco ME, Hammel J, Greenblatt B, Cluzet VC, Cruser D, Oei K, Abinante M, Hammitt LL, Sutcliffe CG, Forthal DN, Zand MS, Cachay ER, Raval JS, Kassaye SG, Foster EC, Roth M, Marshall CE, Yarava A, Lane K, McBee NA, Gawad AL, Karlen N, Singh A, Ford DE, Jabs DA, Appel LJ, Shade DM, Ehrhardt S, Baksh SN, Laeyendecker O, Pekosz A, Klein SL, Casadevall A, Tobian AAR, Hanley DF. PMID: 35353960; PMCID: PMC9006786.
      View in: PubMed   Mentions: 121     Fields:    Translation:Humans
    7. Peripheral blood gene expression profiling shows predictive significance for response to mycophenolate in systemic sclerosis-related interstitial lung disease. Ann Rheum Dis. 2022 06; 81(6):854-860. Assassi S, Volkmann ER, Zheng WJ, Wang X, Wilhalme H, Lyons MA, Roth MD, Tashkin DP. PMID: 35190386; PMCID: PMC9117450.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    8. Randomized Controlled Trial of Early Outpatient COVID-19 Treatment with High-Titer Convalescent Plasma. medRxiv. 2021 Dec 21. Sullivan DJ, Gebo KA, Shoham S, Bloch EM, Lau B, Shenoy AG, Mosnaim GS, Gniadek TJ, Fukuta Y, Patel B, Heath SL, Levine AC, Meisenberg BR, Spivak ES, Anjan S, Huaman MA, Blair JE, Currier JS, Paxton JH, Gerber JM, Petrini JR, Broderick PB, Rausch W, Cordisco ME, Hammel J, Greenblatt B, Cluzet VC, Cruser D, Oei K, Abinante M, Hammitt LL, Sutcliffe CG, Forthal DN, Zand MS, Cachay ER, Raval JS, Kassaye SG, Foster EC, Roth M, Marshall CE, Yarava A, Lane K, McBee NA, Gawad AL, Karlen N, Singh A, Ford DE, Jabs DA, Appel LJ, Shade DM, Ehrhardt S, Baksh SN, Laeyendecker O, Pekosz A, Klein SL, Casadevall A, Tobian AAR, Hanley DF. PMID: 34981068; PMCID: PMC8722611.
      View in: PubMed   Mentions: 2  
    9. Early Radiographic Progression of Scleroderma: Lung Disease Predicts Long-term Mortality. Chest. 2022 05; 161(5):1310-1319. Volkmann ER, Tashkin DP, Roth MD, Goldin J, Kim GHJ. PMID: 34896093; PMCID: PMC9131045.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Systemic Sclerosis-Associated Interstitial Lung Disease: How to Incorporate Two Food and Drug Administration-Approved Therapies in Clinical Practice. Arthritis Rheumatol. 2022 01; 74(1):13-27. Khanna D, Lescoat A, Roofeh D, Bernstein EJ, Kazerooni EA, Roth MD, Martinez F, Flaherty KR, Denton CP. PMID: 34313399; PMCID: PMC8730677.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    11. High 68 Ga-FAPI-46 uptake in a pulmonary necrotizing granuloma in a patient with subcutaneous lipoma. Eur J Nucl Med Mol Imaging. 2022 02; 49(3):1088-1089. Hotta M, Benz MR, Allen-Auerbach MS, Crompton JG, Roth MD, Eilber FC, Calais J. PMID: 34546387.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Predictive Significance of Serum Interferon-Inducible Protein Score for Response to Treatment in Systemic Sclerosis-Related Interstitial Lung Disease. Arthritis Rheumatol. 2021 06; 73(6):1005-1013. Assassi S, Li N, Volkmann ER, Mayes MD, Rünger D, Ying J, Roth MD, Hinchcliff M, Khanna D, Frech T, Clements PJ, Furst DE, Goldin J, Bernstein EJ, Castelino FV, Domsic RT, Gordon JK, Hant FN, Shah AA, Shanmugam VK, Steen VD, Elashoff RM, Tashkin DP. PMID: 33350170; PMCID: PMC8169525.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    13. Racial Disparities in Systemic Sclerosis: Short- and Long-Term Outcomes Among African American Participants of SLS I and II. ACR Open Rheumatol. 2021 Jan; 3(1):8-16. Volkmann ER, Steen V, Li N, Roth MD, Clements PJ, Furst DE, Assassi S, Khanna D, Kim GJ, Goldin J, Elashoff RM, Tashkin DP. PMID: 33277978; PMCID: PMC7811695.
      View in: PubMed   Mentions: 6  
    14. The MUC5B promoter variant does not predict progression of interstitial lung disease in systemic sclerosis. Semin Arthritis Rheum. 2020 10; 50(5):963-967. Volkmann ER, Tashkin DP, Roth MD, Li N, Charles J, Mayes M, Kim G, Goldin J, Pourzand L, Clements PJ, Furst DE, Khanna D, Elashoff RM, Assassi S. PMID: 32906032; PMCID: PMC7584725.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Treatment With Mycophenolate and Cyclophosphamide Leads to Clinically Meaningful Improvements in Patient-Reported Outcomes in Scleroderma Lung Disease: Results of Scleroderma Lung Study II. ACR Open Rheumatol. 2020 Jun; 2(6):362-370. Volkmann ER, Tashkin DP, LeClair H, Roth MD, Kim G, Goldin J, Clements PJ, Furst DE, Khanna D. PMID: 32432411; PMCID: PMC7301868.
      View in: PubMed   Mentions: 18  
    16. Peri-tumor administration of controlled release anti-CTLA-4 synergizes with systemic anti-PD-1 to induce systemic antitumor immunity while sparing autoimmune toxicity. Cancer Immunol Immunother. 2020 Sep; 69(9):1737-1749. Harui A, McLachlan SM, Rapoport B, Zarembinski TI, Roth MD. PMID: 32333082.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Impact of marijuana smoking on lung function in older persons. Eur Respir J. 2020 02; 55(2). Tashkin DP, Roth MD. PMID: 32079670.
      View in: PubMed   Mentions: 2     Fields:    
    18. Using Transitional Changes on High-Resolution Computed Tomography to Monitor the Impact of Cyclophosphamide or Mycophenolate Mofetil on Systemic Sclerosis-Related Interstitial Lung Disease. Arthritis Rheumatol. 2020 02; 72(2):316-325. Kim GHJ, Tashkin DP, Lo P, Brown MS, Volkmann ER, Gjertson DW, Khanna D, Elashoff RM, Tseng CH, Roth MD, Goldin JG. PMID: 31430058; PMCID: PMC6994370.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    19. Parenchymal pericytes are not the major contributor of extracellular matrix in the fibrotic scar after stroke in male mice. J Neurosci Res. 2020 05; 98(5):826-842. Roth M, Enström A, Aghabeick C, Carlsson R, Genové G, Paul G. PMID: 31758600; PMCID: PMC7154736.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    20. Progression of Interstitial Lung Disease in Systemic Sclerosis: The Importance of Pneumoproteins Krebs von den Lungen 6 and CCL18. Arthritis Rheumatol. 2019 12; 71(12):2059-2067. Volkmann ER, Tashkin DP, Kuwana M, Li N, Roth MD, Charles J, Hant FN, Bogatkevich GS, Akter T, Kim G, Goldin J, Khanna D, Clements PJ, Furst DE, Elashoff RM, Silver RM, Assassi S. PMID: 31233287; PMCID: PMC6883123.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    21. Employing a glutathione-s-transferase-tag and hyaluronidase to control cytokine retention and release from a hyaluronic acid hydrogel matrix. J Biomater Appl. 2019 11; 34(5):631-639. Harui A, Roth MD. PMID: 31387421.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Pulmonary effects of inhaled cannabis smoke. Am J Drug Alcohol Abuse. 2019; 45(6):596-609. Tashkin DP, Roth MD. PMID: 31298945.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    23. Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke. FASEB J. 2019 08; 33(8):8990-8998. Roth M, Gaceb A, Enström A, Padel T, Genové G, Özen I, Paul G. PMID: 31039042; PMCID: PMC6662981.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Cyclophosphamide for Systemic Sclerosis-related Interstitial Lung Disease: A Comparison of Scleroderma Lung Study I and II. J Rheumatol. 2019 10; 46(10):1316-1325. Volkmann ER, Tashkin DP, Sim M, Li N, Khanna D, Roth MD, Clements PJ, Hoffmann-Vold AM, Furst DE, Kim G, Goldin J, Elashoff RM. PMID: 30770517; PMCID: PMC6697251.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    25. Minimal Clinically Important Differences for the Modified Rodnan Skin Score: Results from the Scleroderma Lung Studies (SLS-I and SLS-II). Arthritis Res Ther. 2019 01 16; 21(1):23. Khanna D, Clements PJ, Volkmann ER, Wilhalme H, Tseng CH, Furst DE, Roth MD, Distler O, Tashkin DP. PMID: 30651141; PMCID: PMC6335851.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    26. Short-term progression of interstitial lung disease in systemic sclerosis predicts long-term survival in two independent clinical trial cohorts. Ann Rheum Dis. 2019 01; 78(1):122-130. Volkmann ER, Tashkin DP, Sim M, Li N, Goldmuntz E, Keyes-Elstein L, Pinckney A, Furst DE, Clements PJ, Khanna D, Steen V, Schraufnagel DE, Arami S, Hsu V, Roth MD, Elashoff RM, Sullivan KM, SLS I and SLS II study groups. PMID: 30409830; PMCID: PMC6311344.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    27. Longitudinal Changes in Quantitative Interstitial Lung Disease on Computed Tomography after Immunosuppression in the Scleroderma Lung Study II. Ann Am Thorac Soc. 2018 11; 15(11):1286-1295. Goldin JG, Kim GHJ, Tseng CH, Volkmann E, Furst D, Clements P, Brown M, Roth M, Khanna D, Tashkin DP. PMID: 30265153; PMCID: PMC6322015.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    28. Loss of Regulator of G-Protein Signaling 5 Leads to Neurovascular Protection in Stroke. Stroke. 2018 09; 49(9):2182-2190. Özen I, Roth M, Barbariga M, Gaceb A, Deierborg T, Genové G, Paul G. PMID: 30354999; PMCID: PMC6116795.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    29. Brain pericyte activation occurs early in Huntington's disease. Exp Neurol. 2018 07; 305:139-150. Padel T, Roth M, Gaceb A, Li JY, Björkqvist M, Paul G. PMID: 29630897.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    30. STAT3 precedes HIF1α transcriptional responses to oxygen and oxygen and glucose deprivation in human brain pericytes. PLoS One. 2018; 13(3):e0194146. Carlsson R, Özen I, Barbariga M, Gaceb A, Roth M, Paul G. PMID: 29518129; PMCID: PMC5843348.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    31. Efficacy of Mycophenolate Mofetil and Oral Cyclophosphamide on Skin Thickness: Post Hoc Analyses From Two Randomized Placebo-Controlled Trials. Arthritis Care Res (Hoboken). 2018 03; 70(3):439-444. Namas R, Tashkin DP, Furst DE, Wilhalme H, Tseng CH, Roth MD, Kafaja S, Volkmann E, Clements PJ, Khanna D, Participants in the Scleroderma Lung Study I and members of the Scleroderma Lung Study II Research G. PMID: 28544580; PMCID: PMC5700860.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    32. A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers. J Neuroimmune Pharmacol. 2018 06; 13(2):219-229. Kiertscher SM, Gangalum PR, Ibrahim G, Tashkin DP, Roth MD. PMID: 29340893; PMCID: PMC5930049.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. Reliability and minimal clinically important differences of forced vital capacity: Results from the Scleroderma Lung Studies (SLS-I and SLS-II). Am J Respir Crit Care Med. 2018 03 01; 197(5):644-652. Kafaja S, Clements PJ, Wilhalme H, Tseng CH, Furst DE, Kim GH, Goldin J, Volkmann ER, Roth MD, Tashkin DP, Khanna D. PMID: 29099620; PMCID: PMC6008871.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    34. Mycophenolate Mofetil Versus Placebo for Systemic Sclerosis-Related Interstitial Lung Disease: An Analysis of Scleroderma Lung Studies I and II. Arthritis Rheumatol. 2017 07; 69(7):1451-1460. Volkmann ER, Tashkin DP, Li N, Roth MD, Khanna D, Hoffmann-Vold AM, Kim G, Goldin J, Clements PJ, Furst DE, Elashoff RM. PMID: 28376288; PMCID: PMC5560126.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    35. Regulation of Cell Surface CB2 Receptor during Human B Cell Activation and Differentiation. J Neuroimmune Pharmacol. 2017 09; 12(3):544-554. Castaneda JT, Harui A, Roth MD. PMID: 28364261; PMCID: PMC5529268.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    36. Changes in plasma CXCL4 levels are associated with improvements in lung function in patients receiving immunosuppressive therapy for systemic sclerosis-related interstitial lung disease. Arthritis Res Ther. 2016 12 30; 18(1):305. Volkmann ER, Tashkin DP, Roth MD, Clements PJ, Khanna D, Furst DE, Mayes M, Charles J, Tseng CH, Elashoff RM, Assassi S. PMID: 28038680; PMCID: PMC5203703.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    37. Improved Cough and Cough-Specific Quality of Life in Patients Treated for Scleroderma-Related Interstitial Lung Disease: Results of Scleroderma Lung Study II. Chest. 2017 Apr; 151(4):813-820. Tashkin DP, Volkmann ER, Tseng CH, Roth MD, Khanna D, Furst DE, Clements PJ, Theodore A, Kafaja S, Kim GH, Goldin J, Ariolla E, Elashoff RM. PMID: 28012804; PMCID: PMC5472514.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    38. Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial. Lancet Respir Med. 2016 09; 4(9):708-719. Tashkin DP, Roth MD, Clements PJ, Furst DE, Khanna D, Kleerup EC, Goldin J, Arriola E, Volkmann ER, Kafaja S, Silver R, Steen V, Strange C, Wise R, Wigley F, Mayes M, Riley DJ, Hussain S, Assassi S, Hsu VM, Patel B, Phillips K, Martinez F, Golden J, Connolly MK, Varga J, Dematte J, Hinchcliff ME, Fischer A, Swigris J, Meehan R, Theodore A, Simms R, Volkov S, Schraufnagel DE, Scholand MB, Frech T, Molitor JA, Highland K, Read CA, Fritzler MJ, Kim GHJ, Tseng CH, Elashoff RM, Sclerodema Lung Study II Investigators. PMID: 27469583; PMCID: PMC5014629.
      View in: PubMed   Mentions: 355     Fields:    Translation:Humans
    39. Platelet-derived growth factor-BB has neurorestorative effects and modulates the pericyte response in a partial 6-hydroxydopamine lesion mouse model of Parkinson's disease. Neurobiol Dis. 2016 Oct; 94:95-105. Padel T, Özen I, Boix J, Barbariga M, Gaceb A, Roth M, Paul G. PMID: 27288154.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    40. Transitions to different patterns of interstitial lung disease in scleroderma with and without treatment. Ann Rheum Dis. 2016 Jul; 75(7):1367-71. Kim HJ, Tashkin DP, Gjertson DW, Brown MS, Kleerup E, Chong S, Belperio JA, Roth MD, Abtin F, Elashoff R, Tseng CH, Khanna D, Goldin JG. PMID: 26757749.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    41. Predictors of lung function decline in scleroderma-related interstitial lung disease based on high-resolution computed tomography: implications for cohort enrichment in systemic sclerosis-associated interstitial lung disease trials. Arthritis Res Ther. 2015 Dec 23; 17:372. Khanna D, Nagaraja V, Tseng CH, Abtin F, Suh R, Kim G, Wells A, Furst DE, Clements PJ, Roth MD, Tashkin DP, Goldin J. PMID: 26704522; PMCID: PMC4718035.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    42. Human tumor infiltrating lymphocytes cooperatively regulate prostate tumor growth in a humanized mouse model. J Immunother Cancer. 2015; 3:12. Roth MD, Harui A. PMID: 25901284; PMCID: PMC4404579.
      View in: PubMed   Mentions: 19     Fields:    
    43. Exposure to Δ9-Tetrahydrocannabinol Impairs the Differentiation of Human Monocyte-derived Dendritic Cells and their Capacity for T cell Activation. J Neuroimmune Pharmacol. 2015 Jun; 10(2):333-43. Roth MD, Castaneda JT, Kiertscher SM. PMID: 25614186; PMCID: PMC4470806.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    44. Relationship between quantitative radiographic assessments of interstitial lung disease and physiological and clinical features of systemic sclerosis. Ann Rheum Dis. 2016 Feb; 75(2):374-81. Tashkin DP, Volkmann ER, Tseng CH, Kim HJ, Goldin J, Clements P, Furst D, Khanna D, Kleerup E, Roth MD, Elashoff R. PMID: 25452309.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    45. Pleural effusions, eosinophilia and a positive interferon-γ release assay. Respiration. 2013; 86(6):508-11. Howard-Anderson J, Canan T, Roth MD, Ha E. PMID: 24217390.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsPHPublic Health
    46. Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013 Oct 15; 188(8):948-57. Cheng DT, Kim DK, Cockayne DA, Belousov A, Bitter H, Cho MH, Duvoix A, Edwards LD, Lomas DA, Miller BE, Reynaert N, Tal-Singer R, Wouters EF, Agustí A, Fabbri LM, Rames A, Visvanathan S, Rennard SI, Jones P, Parmar H, MacNee W, Wolff G, Silverman EK, Mayer RJ, Pillai SG, TESRA and ECLIPSE Investigators. PMID: 23947473.
      View in: PubMed   Mentions: 84     Fields:    Translation:Humans
    47. Increased matrix metalloproteinase (MMPs) levels do not predict disease severity or progression in emphysema. PLoS One. 2013; 8(2):e56352. D'Armiento JM, Goldklang MP, Hardigan AA, Geraghty P, Roth MD, Connett JE, Wise RA, Sciurba FC, Scharf SM, Thankachen J, Islam M, Ghio AJ, Foronjy RF. PMID: 23441181; PMCID: PMC3575373.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    48. Differential expression of intracellular and extracellular CB(2) cannabinoid receptor protein by human peripheral blood leukocytes. J Neuroimmune Pharmacol. 2013 Mar; 8(1):323-32. Castaneda JT, Harui A, Kiertscher SM, Roth JD, Roth MD. PMID: 23299999; PMCID: PMC3587044.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    49. Clinical course of lung physiology in patients with scleroderma and interstitial lung disease: analysis of the Scleroderma Lung Study Placebo Group. Arthritis Rheum. 2011 Oct; 63(10):3078-85. Khanna D, Tseng CH, Farmani N, Steen V, Furst DE, Clements PJ, Roth MD, Goldin J, Elashoff R, Seibold JR, Saggar R, Tashkin DP. PMID: 21618205; PMCID: PMC3183128.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    50. Predicting treatment outcomes and responder subsets in scleroderma-related interstitial lung disease. Arthritis Rheum. 2011 Sep; 63(9):2797-808. Roth MD, Tseng CH, Clements PJ, Furst DE, Tashkin DP, Goldin JG, Khanna D, Kleerup EC, Li N, Elashoff D, Elashoff RM, Scleroderma Lung Study Research Group. PMID: 21547897; PMCID: PMC3910296.
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    51. Lung cancer chemoprevention with celecoxib in former smokers. Cancer Prev Res (Phila). 2011 Jul; 4(7):984-93. Mao JT, Roth MD, Fishbein MC, Aberle DR, Zhang ZF, Rao JY, Tashkin DP, Goodglick L, Holmes EC, Cameron RB, Dubinett SM, Elashoff R, Szabo E, Elashoff D. PMID: 21733822; PMCID: PMC3153413.
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    52. Adverse events during the Scleroderma Lung Study. Am J Med. 2011 May; 124(5):459-67. Furst DE, Tseng CH, Clements PJ, Strange C, Tashkin DP, Roth MD, Khanna D, Li N, Elashoff R, Schraufnagel DE, Scleroderma Lung Study. PMID: 21531236.
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    53. Course of dermal ulcers and musculoskeletal involvement in systemic sclerosis patients in the scleroderma lung study. Arthritis Care Res (Hoboken). 2010 Dec; 62(12):1772-8. Au K, Mayes MD, Maranian P, Clements PJ, Khanna D, Steen VD, Tashkin D, Roth MD, Elashoff R, Furst DE. PMID: 20740615; PMCID: PMC2994974.
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    54. Reconstitution of huPBL-NSG mice with donor-matched dendritic cells enables antigen-specific T-cell activation. J Neuroimmune Pharmacol. 2011 Mar; 6(1):148-57. Harui A, Kiertscher SM, Roth MD. PMID: 20532647; PMCID: PMC3028099.
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    55. Redirecting lentiviral vectors pseudotyped with Sindbis virus-derived envelope proteins to DC-SIGN by modification of N-linked glycans of envelope proteins. J Virol. 2010 Jul; 84(14):6923-34. Morizono K, Ku A, Xie Y, Harui A, Kung SK, Roth MD, Lee B, Chen IS. PMID: 20484510; PMCID: PMC2898243.
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    56. Eosinophil and T cell markers predict functional decline in COPD patients. Respir Res. 2009 Nov 19; 10:113. D'Armiento JM, Scharf SM, Roth MD, Connett JE, Ghio A, Sternberg D, Goldin JG, Louis TA, Mao JT, O'Connor GT, Ramsdell JW, Ries AL, Schluger NW, Sciurba FC, Skeans MA, Voelker H, Walter RE, Wendt CH, Weinmann GG, Wise RA, Foronjy RF. PMID: 19925666; PMCID: PMC2785783.
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    57. Treatment of scleroderma-interstitial lung disease with cyclophosphamide is associated with less progressive fibrosis on serial thoracic high-resolution CT scan than placebo: findings from the scleroderma lung study. Chest. 2009 Nov; 136(5):1333-1340. Goldin J, Elashoff R, Kim HJ, Yan X, Lynch D, Strollo D, Roth MD, Clements P, Furst DE, Khanna D, Vasunilashorn S, Li G, Tashkin DP. PMID: 19892673; PMCID: PMC2773360.
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    58. Minimally important differences in the Mahler's Transition Dyspnoea Index in a large randomized controlled trial--results from the Scleroderma Lung Study. Rheumatology (Oxford). 2009 Dec; 48(12):1537-40. Khanna D, Tseng CH, Furst DE, Clements PJ, Elashoff R, Roth M, Elashoff D, Tashkin DP, for Scleroderma Lung Study Investigators. PMID: 19776222; PMCID: PMC2777487.
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    59. Recruitment strategies for a lung cancer chemoprevention trial involving ex-smokers. Contemp Clin Trials. 2009 Sep; 30(5):464-72. Kye SH, Tashkin DP, Roth MD, Adams B, Nie WX, Mao JT. PMID: 19508900.
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    60. Recreational drug use and risk of Kaposi's sarcoma in HIV- and HHV-8-coinfected homosexual men. AIDS Res Hum Retroviruses. 2009 Feb; 25(2):149-56. Chao C, Jacobson LP, Jenkins FJ, Tashkin D, Martínez-Maza O, Roth MD, Ng L, Margolick JB, Chmiel JS, Zhang ZF, Detels R. PMID: 19108691; PMCID: PMC2981355.
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    61. Recreational amphetamine use and risk of HIV-related non-Hodgkin lymphoma. Cancer Causes Control. 2009 Jul; 20(5):509-16. Chao C, Jacobson LP, Tashkin D, Martínez-Maza O, Roth MD, Margolick JB, Chmiel JS, Holloway MN, Zhang ZF, Detels R. PMID: 19011979; PMCID: PMC2862618.
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    62. High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung disease. Chest. 2008 Aug; 134(2):358-367. Goldin JG, Lynch DA, Strollo DC, Suh RD, Schraufnagel DE, Clements PJ, Elashoff RM, Furst DE, Vasunilashorn S, McNitt-Gray MF, Brown MS, Roth MD, Tashkin DP, Scleroderma Lung Study Research Group. PMID: 18641099.
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    63. Clarifying CB2 receptor-dependent and independent effects of THC on human lung epithelial cells. Toxicol Appl Pharmacol. 2008 Sep 15; 231(3):282-90. Sarafian T, Montes C, Harui A, Beedanagari SR, Kiertscher S, Stripecke R, Hossepian D, Kitchen C, Kern R, Belperio J, Roth MD. PMID: 18556036; PMCID: PMC2615389.
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    64. Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men. Drug Alcohol Depend. 2008 Apr 01; 94(1-3):165-71. Chao C, Jacobson LP, Tashkin D, Martínez-Maza O, Roth MD, Margolick JB, Chmiel JS, Rinaldo C, Zhang ZF, Detels R. PMID: 18180115; PMCID: PMC2691391.
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    65. Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patients. J Clin Pharmacol. 2008 Jan; 48(1):96-107. Muindi JR, Roth MD, Wise RA, Connett JE, O'Connor GT, Ramsdell JW, Schluger NW, Romkes M, Branch RA, Sciurba FC, FORTE Study Investigators. PMID: 18094222.
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    66. Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung disease. Am J Respir Crit Care Med. 2008 Jan 01; 177(1):91-8. Strange C, Bolster MB, Roth MD, Silver RM, Theodore A, Goldin J, Clements P, Chung J, Elashoff RM, Suh R, Smith EA, Furst DE, Tashkin DP, Scleroderma Lung Study Research Group. PMID: 17901414; PMCID: PMC2176114.
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    67. Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease. Am J Respir Crit Care Med. 2007 Nov 15; 176(10):1026-34. Tashkin DP, Elashoff R, Clements PJ, Roth MD, Furst DE, Silver RM, Goldin J, Arriola E, Strange C, Bolster MB, Seibold JR, Riley DJ, Hsu VM, Varga J, Schraufnagel D, Theodore A, Simms R, Wise R, Wigley F, White B, Steen V, Read C, Mayes M, Parsley E, Mubarak K, Connolly MK, Golden J, Olman M, Fessler B, Rothfield N, Metersky M, Khanna D, Li N, Li G, Scleroderma Lung Study Research Group. PMID: 17717203; PMCID: PMC2078679.
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    68. Scleroderma lung study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosis. Ann Rheum Dis. 2007 Dec; 66(12):1641-7. Clements PJ, Roth MD, Elashoff R, Tashkin DP, Goldin J, Silver RM, Sterz M, Seibold JR, Schraufnagel D, Simms RW, Bolster M, Wise RA, Steen V, Mayes MD, Connelly K, Metersky M, Furst DE, Scleroderma Lung Study Group. PMID: 17485423; PMCID: PMC2095310.
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    69. Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: results from the scleroderma lung study. Arthritis Rheum. 2007 May; 56(5):1676-84. Khanna D, Yan X, Tashkin DP, Furst DE, Elashoff R, Roth MD, Silver R, Strange C, Bolster M, Seibold JR, Riley DJ, Hsu VM, Varga J, Schraufnagel DE, Theodore A, Simms R, Wise R, Wigley F, White B, Steen V, Read C, Mayes M, Parsley E, Mubarak K, Connolly MK, Golden J, Olman M, Fessler B, Rothfield N, Metersky M, Clements PJ, Scleroderma Lung Study Group. PMID: 17469162.
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    70. Pharmacokinetics of a novel agent, R667, in patients with emphysema. Br J Clin Pharmacol. 2007 May; 63(5):527-33. Chiu YY, Roth MD, Kolis S, Rogovitz D, Davies B. PMID: 17324249; PMCID: PMC2000757.
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    71. Feasibility of retinoids for the treatment of emphysema study. Chest. 2006 Nov; 130(5):1334-45. Roth MD, Connett JE, D'Armiento JM, Foronjy RF, Friedman PJ, Goldin JG, Louis TA, Mao JT, Muindi JR, O'Connor GT, Ramsdell JW, Ries AL, Scharf SM, Schluger NW, Sciurba FC, Skeans MA, Walter RE, Wendt CH, Wise RA, FORTE Study Investigators. PMID: 17099008.
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    72. Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med. 2006 Jun 22; 354(25):2655-66. Tashkin DP, Elashoff R, Clements PJ, Goldin J, Roth MD, Furst DE, Arriola E, Silver R, Strange C, Bolster M, Seibold JR, Riley DJ, Hsu VM, Varga J, Schraufnagel DE, Theodore A, Simms R, Wise R, Wigley F, White B, Steen V, Read C, Mayes M, Parsley E, Mubarak K, Connolly MK, Golden J, Olman M, Fessler B, Rothfield N, Metersky M, Scleroderma Lung Study Research Group. PMID: 16790698.
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    73. Centrifugation enhances integrin-mediated transduction of dendritic cells by conventional and RGD-modified adenoviral vectors. J Immunol Methods. 2006 May 30; 312(1-2):94-104. Harui A, Roth MD, Sanghvi M, Vira D, Mizuguchi H, Basak SK. PMID: 16626731.
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    74. Adenoviral-encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of alpha(v)beta3 integrins. J Leukoc Biol. 2006 Jun; 79(6):1271-8. Harui A, Roth MD, Vira D, Sanghvi M, Mizuguchi H, Basak SK. PMID: 16574766.
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    75. Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1202-9. Sarafian TA, Habib N, Oldham M, Seeram N, Lee RP, Lin L, Tashkin DP, Roth MD. PMID: 16414979.
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    76. Celecoxib decreases Ki-67 proliferative index in active smokers. Clin Cancer Res. 2006 Jan 01; 12(1):314-20. Mao JT, Fishbein MC, Adams B, Roth MD, Goodglick L, Hong L, Burdick M, Strieter ER, Holmes C, Tashkin DP, Dubinett SM. PMID: 16397057.
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    77. Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model. J Leukoc Biol. 2005 Dec; 78(6):1198-203. Roth MD, Whittaker KM, Choi R, Tashkin DP, Baldwin GC. PMID: 16204638.
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    78. Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouse. Life Sci. 2005 Aug 19; 77(14):1711-22. Roth MD, Tashkin DP, Whittaker KM, Choi R, Baldwin GC. PMID: 15964028.
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    79. Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment. Clin Cancer Res. 2005 Aug 01; 11(15):5515-25. Liau LM, Prins RM, Kiertscher SM, Odesa SK, Kremen TJ, Giovannone AJ, Lin JW, Chute DJ, Mischel PS, Cloughesy TF, Roth MD. PMID: 16061868.
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    80. Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14; 158(2):95-107. Sarafian T, Habib N, Mao JT, Tsu IH, Yamamoto ML, Hsu E, Tashkin DP, Roth MD. PMID: 16039398.
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    81. Pharmacology: marijuana and your heart. Nature. 2005 Apr 07; 434(7034):708-9. Roth MD. PMID: 15815611.
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    82. Correlation of the degree of dyspnea with health-related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: results from the Scleroderma Lung Study. Arthritis Rheum. 2005 Feb; 52(2):592-600. Khanna D, Clements PJ, Furst DE, Chon Y, Elashoff R, Roth MD, Sterz MG, Chung J, FitzGerald JD, Seibold JR, Varga J, Theodore A, Wigley FM, Silver RM, Steen VD, Mayes MD, Connolly MK, Fessler BJ, Rothfield NF, Mubarak K, Molitor J, Tashkin DP, Scleroderma Lung Study Group. PMID: 15692967.
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    83. Vaccination with helper-dependent adenovirus enhances the generation of transgene-specific CTL. Gene Ther. 2004 Nov; 11(22):1617-26. Harui A, Roth MD, Kiertscher SM, Mitani K, Basak SK. PMID: 15295617.
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    84. Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide. Clin Cancer Res. 2004 Oct 15; 10(20):6872-8. Mao JT, Tsu IH, Dubinett SM, Adams B, Sarafian T, Baratelli F, Roth MD, Serio KJ. PMID: 15501964.
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    85. Regional differences in bronchoalveolar lavage and thoracic high-resolution computed tomography results in dyspneic patients with systemic sclerosis. Arthritis Rheum. 2004 Jun; 50(6):1909-17. Clements PJ, Goldin JG, Kleerup EC, Furst DE, Elashoff RM, Tashkin DP, Roth MD. PMID: 15188367.
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    86. Cocaine modulates cytokine and enhances tumor growth through sigma receptors. J Neuroimmunol. 2004 Feb; 147(1-2):95-8. Gardner B, Zhu LX, Roth MD, Tashkin DP, Dubinett SM, Sharma S. PMID: 14741436.
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    87. Mechanisms for impaired effector function in alveolar macrophages from marijuana and cocaine smokers. J Neuroimmunol. 2004 Feb; 147(1-2):82-6. Roth MD, Whittaker K, Salehi K, Tashkin DP, Baldwin GC. PMID: 14741433.
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    88. Modifying adenoviral vectors for use as gene-based cancer vaccines. Viral Immunol. 2004; 17(2):182-96. Basak SK, Kiertscher SM, Harui A, Roth MD. PMID: 15279698.
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    89. Celecoxib modulates the capacity for prostaglandin E2 and interleukin-10 production in alveolar macrophages from active smokers. Clin Cancer Res. 2003 Dec 01; 9(16 Pt 1):5835-41. Mao JT, Roth MD, Serio KJ, Baratelli F, Zhu L, Holmes EC, Strieter RM, Dubinett SM. PMID: 14676104.
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    90. Granulocyte/macrophage-colony stimulating factor and interleukin-4 expand and activate type-1 dendritic cells (DC1) when administered in vivo to cancer patients. Int J Cancer. 2003 Nov 01; 107(2):256-61. Kiertscher SM, Gitlitz BJ, Figlin RA, Roth MD. PMID: 12949803.
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    91. All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysema. Chest. 2003 Nov; 124(5):1724-32. Mao JT, Tashkin DP, Belloni PN, Baileyhealy I, Baratelli F, Roth MD. PMID: 14605041.
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    92. Phase I trial of granulocyte macrophage-colony stimulating factor and interleukin-4 as a combined immunotherapy for patients with cancer. J Immunother. 2003 Mar-Apr; 26(2):171-8. Gitlitz BJ, Figlin RA, Kiertscher SM, Moldawer N, Rosen F, Roth MD. PMID: 12616109.
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    93. Impairment of antimicrobial activity and nitric oxide production in alveolar macrophages from smokers of marijuana and cocaine. J Infect Dis. 2003 Feb 15; 187(4):700-4. Shay AH, Choi R, Whittaker K, Salehi K, Kitchen CM, Tashkin DP, Roth MD, Baldwin GC. PMID: 12599091.
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    94. Effects of delta-9-tetrahydrocannabinol on human immune function and host defense. Chem Phys Lipids. 2002 Dec 31; 121(1-2):229-39. Roth MD, Baldwin GC, Tashkin DP. PMID: 12505703.
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    95. Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells. J Neuroimmunol. 2002 Dec; 133(1-2):124-31. Yuan M, Kiertscher SM, Cheng Q, Zoumalan R, Tashkin DP, Roth MD. PMID: 12446015.
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    96. Respiratory and immunologic consequences of marijuana smoking. J Clin Pharmacol. 2002 11; 42(S1):71S-81S. Tashkin DP, Baldwin GC, Sarafian T, Dubinett S, Roth MD. PMID: 12412839.
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    97. Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energetics. Am J Physiol Lung Cell Mol Physiol. 2003 Feb; 284(2):L298-306. Sarafian TA, Kouyoumjian S, Khoshaghideh F, Tashkin DP, Roth MD. PMID: 12533310.
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    98. Helper-dependent adenoviral vectors efficiently express transgenes in human dendritic cells but still stimulate antiviral immune responses. J Immunol. 2002 Oct 15; 169(8):4651-6. Roth MD, Cheng Q, Harui A, Basak SK, Mitani K, Low TA, Kiertscher SM. PMID: 12370405.
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    99. Synergistic cytotoxicity of Delta(9)-tetrahydrocannabinol and butylated hydroxyanisole. Toxicol Lett. 2002 Jul 21; 133(2-3):171-9. Sarafian TA, Kouyoumjian S, Tashkin D, Roth MD. PMID: 12119125.
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    100. Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers. J Neuroimmunol. 2002 Jun; 127(1-2):169-76. Nong L, Newton C, Cheng Q, Friedman H, Roth MD, Klein TW. PMID: 12044989.
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    101. Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4. Blood. 2002 Apr 15; 99(8):2869-79. Basak SK, Harui A, Stolina M, Sharma S, Mitani K, Dubinett SM, Roth MD. PMID: 11929777.
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    102. Evidence of chronic damage to the pulmonary microcirculation in habitual users of alkaloidal ("crack") cocaine. Chest. 2002 Apr; 121(4):1231-8. Baldwin GC, Choi R, Roth MD, Shay AH, Kleerup EC, Simmons MS, Tashkin DP. PMID: 11948058.
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    103. A pilot study of all-trans-retinoic acid for the treatment of human emphysema. Am J Respir Crit Care Med. 2002 Mar 01; 165(5):718-23. Mao JT, Goldin JG, Dermand J, Ibrahim G, Brown MS, Emerick A, McNitt-Gray MF, Gjertson DW, Estrada F, Tashkin DP, Roth MD. PMID: 11874821.
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    104. Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytes. J Infect Dis. 2002 Mar 01; 185(5):701-5. Roth MD, Tashkin DP, Choi R, Jamieson BD, Zack JA, Baldwin GC. PMID: 11865430.
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    105. Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis. Toxicol Appl Pharmacol. 2001 Aug 01; 174(3):264-72. Sarafian TA, Tashkin DP, Roth MD. PMID: 11485387.
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    106. Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol. Am J Respir Cell Mol Biol. 2001 Mar; 24(3):339-44. Roth MD, Marques-Magallanes JA, Yuan M, Sun W, Tashkin DP, Hankinson O. PMID: 11245634.
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    107. Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J Immunol. 2001 Feb 15; 166(4):2444-50. Hertz CJ, Kiertscher SM, Godowski PJ, Bouis DA, Norgard MV, Roth MD, Modlin RL. PMID: 11160304.
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    108. Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10. J Immunol. 2000 Oct 01; 165(7):3804-10. Thoma-Uszynski S, Kiertscher SM, Ochoa MT, Bouis DA, Norgard MV, Miyake K, Godowski PJ, Roth MD, Modlin RL. PMID: 11034386.
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    109. Delta-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. J Immunol. 2000 Jul 01; 165(1):373-80. Zhu LX, Sharma S, Stolina M, Gardner B, Roth MD, Tashkin DP, Dubinett SM. PMID: 10861074.
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    110. Granulocyte macrophage colony-stimulating factor and interleukin 4 enhance the number and antigen-presenting activity of circulating CD14+ and CD83+ cells in cancer patients. Cancer Res. 2000 Apr 01; 60(7):1934-41. Roth MD, Gitlitz BJ, Kiertscher SM, Park AN, Mendenhall M, Moldawer N, Figlin RA. PMID: 10766183.
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    111. Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells. J Immunol. 2000 Feb 01; 164(3):1269-76. Kiertscher SM, Luo J, Dubinett SM, Roth MD. PMID: 10640740.
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    112. Oxidative stress produced by marijuana smoke. An adverse effect enhanced by cannabinoids. Am J Respir Cell Mol Biol. 1999 Jun; 20(6):1286-93. Sarafian TA, Magallanes JA, Shau H, Tashkin D, Roth MD. PMID: 10340948.
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    113. Presentation of renal tumor antigens by human dendritic cells activates tumor-infiltrating lymphocytes against autologous tumor: implications for live kidney cancer vaccines. Clin Cancer Res. 1999 Feb; 5(2):445-54. Mulders P, Tso CL, Gitlitz B, Kaboo R, Hinkel A, Frand S, Kiertscher S, Roth MD, deKernion J, Figlin R, Belldegrun A. PMID: 10037196.
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    114. Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection. J Virol. 1998 Nov; 72(11):9054-60. Kitchen SG, Korin YD, Roth MD, Landay A, Zack JA. PMID: 9765450; PMCID: PMC110322.
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    115. Interferon-alpha and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells. J Leukoc Biol. 1998 Sep; 64(3):358-67. Paquette RL, Hsu NC, Kiertscher SM, Park AN, Tran L, Roth MD, Glaspy JA. PMID: 9738663.
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    116. Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobacco. J Natl Cancer Inst. 1998 Aug 19; 90(16):1198-205. Barsky SH, Roth MD, Kleerup EC, Simmons M, Tashkin DP. PMID: 9719080.
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    117. Acute and chronic effects of cocaine on the immune system and the possible link to AIDS. J Neuroimmunol. 1998 Mar 15; 83(1-2):133-8. Baldwin GC, Roth MD, Tashkin DP. PMID: 9610681.
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    118. Airway inflammation in young marijuana and tobacco smokers. Am J Respir Crit Care Med. 1998 Mar; 157(3 Pt 1):928-37. Roth MD, Arora A, Barsky SH, Kleerup EC, Simmons M, Tashkin DP. PMID: 9517614.
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    119. Highly efficient and consistent gene transfer into dendritic cells utilizing a combination of ultraviolet-irradiated adenovirus and poly(L-lysine) conjugates. Cancer Res. 1998 Mar 01; 58(5):956-61. Mulders P, Pang S, Dannull J, Kaboo R, Hinkel A, Michel K, Tso CL, Roth M, Belldegrun A. PMID: 9500456.
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    120. Marijuana and cocaine impair alveolar macrophage function and cytokine production. Am J Respir Crit Care Med. 1997 Nov; 156(5):1606-13. Baldwin GC, Tashkin DP, Buckley DM, Park AN, Dubinett SM, Roth MD. PMID: 9372683.
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    121. Tracheobronchial histopathology in habitual smokers of cocaine, marijuana, and/or tobacco. Chest. 1997 Aug; 112(2):319-26. Fligiel SE, Roth MD, Kleerup EC, Barsky SH, Simmons MS, Tashkin DP. PMID: 9266864.
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    122. Acute activation of circulating polymorphonuclear neutrophils following in vivo administration of cocaine. A potential etiology for pulmonary injury. Chest. 1997 Mar; 111(3):698-705. Baldwin GC, Buckley DM, Roth MD, Kleerup EC, Tashkin DP. PMID: 9118711.
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    123. A comparison of gene transfer methods in human dendritic cells. Cancer Gene Ther. 1997 Jan-Feb; 4(1):17-25. Arthur JF, Butterfield LH, Roth MD, Bui LA, Kiertscher SM, Lau R, Dubinett S, Glaspy J, McBride WH, Economou JS. PMID: 9012447.
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    124. NIDA conference report on cardiopulmonary complications of "crack" cocaine use. Clinical manifestations and pathophysiology. Chest. 1996 Oct; 110(4):1072-6. Thadani PV. PMID: 8874270.
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    125. Interleukin-7 gene transfer in non-small-cell lung cancer decreases tumor proliferation, modifies cell surface molecule expression, and enhances antitumor reactivity. Cancer Gene Ther. 1996 Sep-Oct; 3(5):302-13. Sharma S, Wang J, Huang M, Paul RW, Lee P, McBride WH, Economou JS, Roth MD, Kiertscher SM, Dubinett SM. PMID: 8894249.
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    126. Human CD14+ leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4. J Leukoc Biol. 1996 Feb; 59(2):208-18. Kiertscher SM, Roth MD. PMID: 8603993.
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    127. Effects of smoking marijuana, tobacco or cocaine alone or in combination on DNA damage in human alveolar macrophages. Life Sci. 1995; 56(23-24):2201-7. Sherman MP, Aeberhard EE, Wong VZ, Simmons MS, Roth MD, Tashkin DP. PMID: 7776850.
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    128. Interleukin 2 induces the expression of CD45RO and the memory phenotype by CD45RA+ peripheral blood lymphocytes. J Exp Med. 1994 Mar 01; 179(3):857-64. Roth MD. PMID: 8113679; PMCID: PMC2191429.
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    129. Inhibition of natural killer cell activity by therapeutic levels of theophylline. Am J Respir Cell Mol Biol. 1993 Dec; 9(6):659-65. Coskey LA, Bitting J, Roth MD. PMID: 8257597.
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    130. Pulmonary surfactant inhibits interleukin-2-induced proliferation and the generation of lymphokine-activated killer cells. Am J Respir Cell Mol Biol. 1993 Dec; 9(6):652-8. Roth MD, Pinto M, Golub SH, Shau H. PMID: 8257596.
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    131. Regulation of natural killer function by nonlymphoid cells. Nat Immun. 1993 Jul-Oct; 12(4-5):235-49. Shau H, Roth MD, Golub SH. PMID: 8257829.
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    132. Pulmonary macrophages suppress the proliferation and cytotoxicity of tumor-infiltrating lymphocytes. Am J Respir Cell Mol Biol. 1993 May; 8(5):486-92. Swisher SG, Kiertscher SM, Golub SH, Holmes EC, Roth MD. PMID: 8481233.
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    133. Human pulmonary macrophages utilize prostaglandins and transforming growth factor beta 1 to suppress lymphocyte activation. J Leukoc Biol. 1993 Apr; 53(4):366-71. Roth MD, Golub SH. PMID: 8482916.
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    134. Expression of CD45 isoforms in fresh and IL-2-cultured tumor-infiltrating lymphocytes from basal cell carcinoma. Cell Immunol. 1993 Feb; 146(2):421-30. Nguyen QH, Moy RL, Roth MD, Yamamoto R, Tomono S, Dubinett SM. PMID: 8174180.
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    135. Antimicrobial and respiratory burst characteristics of pulmonary alveolar macrophages recovered from smokers of marijuana alone, smokers of tobacco alone, smokers of marijuana and tobacco, and nonsmokers. Am Rev Respir Dis. 1991 Dec; 144(6):1351-6. Sherman MP, Campbell LA, Gong H, Roth MD, Tashkin DP. PMID: 1660230.
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    136. Marijuana smoking, pulmonary function, and lung macrophage oxidant release. Pharmacol Biochem Behav. 1991 Nov; 40(3):663-9. Sherman MP, Roth MD, Gong H, Tashkin DP. PMID: 1666925.
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    137. Inhibition of lymphokine-activated killer cell function by human alveolar macrophages. Cancer Res. 1989 Sep 01; 49(17):4690-5. Roth MD, Golub SH. PMID: 2788029.
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    138. Gas flow through a bronchopleural fistula. Measuring the effects of high-frequency jet ventilation and chest-tube suction. Chest. 1988 Jan; 93(1):210-3. Roth MD, Wright JW, Bellamy PE. PMID: 3335160.
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    139. Cell-mediated immunity in chronically diabetic mice. Diabetes. 1980 Oct; 29(10):825-9. Roth MD, Barg M, Michalski R, Arquilla ER. PMID: 7439540.
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    140. Induction of hyperglycemia with insulin antibodies to B-chain determinants. Diabetes. 1980 May; 29(5):383-90. Kelso JM, Tamai IY, Roth MD, Valdes I, Arquilla ER. PMID: 6155299.
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