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Belperio John

Title(s)Associate Professor, Pulmonary and Critical Care Medicine
Phone310-825-8061
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    Collapse Research 
    Collapse Research Activities and Funding
    Immune Mechanisms of Alloinjury
    NIH/NHLBI R01HL112990May 15, 2012 - Feb 28, 2017
    Role: Principal Investigator
    The Role of Chemokines During Lung Allograft Dysfunction
    NIH/NHLBI R01HL080206Aug 1, 2005 - Jul 31, 2011
    Role: Principal Investigator
    UCLA IPF Clinical Research Network
    NIH/NHLBI U10HL080411May 1, 2005 - Apr 30, 2012
    Role: Principal Investigator
    CHEMOKINE BIOLOGY IN BRONCHIOLITIS OBLITERANS SYNDROME
    NIH/NHLBI K08HL004493Mar 15, 2001 - Feb 28, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hoffmann-Vold AM, Weigt SS, Saggar R, Palchevskiy V, Volkmann ER, Liang LL, Ross D, Ardehali A, Lynch JP, Belperio JA. Endotype-phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease. EBioMedicine. 2019 Nov 12. PMID: 31732480.
      View in: PubMed
    2. Todd JL, Kelly FL, Nagler A, Banner K, Pavlisko EN, Belperio JA, Brass D, Weigt SS, Palmer SM. Amphiregulin contributes to airway remodeling in chronic allograft dysfunction after lung transplantation. Am J Transplant. 2019 Oct 30. PMID: 31665560.
      View in: PubMed
    3. Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch Iii JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, Golden JA, Leard LE, Shah RJ, Kleinhenz ME, Venado A, Kukreja J, Singer JP, Looney MR. Mitochondrial DNA Stimulates TLR9-Dependent NET Formation in Primary Graft Dysfunction. Am J Respir Cell Mol Biol. 2019 Oct 24. PMID: 31647878.
      View in: PubMed
    4. Todd JL, Neely ML, Overton R, Durham K, Gulati M, Huang H, Roman J, Newby LK, Flaherty KR, Vinisko R, Liu Y, Roy J, Schmid R, Strobel B, Hesslinger C, Leonard TB, Noth I, Belperio JA, Palmer SM. Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry. Respir Res. 2019 Oct 22; 20(1):227. PMID: 31640794.
      View in: PubMed
    5. Kim GHJ, Weigt SS, Belperio JA, Brown MS, Shi Y, Lai JH, Goldin JG. Prediction of idiopathic pulmonary fibrosis progression using early quantitative changes on CT imaging for a short term of clinical 18-24-month follow-ups. Eur Radiol. 2019 Aug 26. PMID: 31451973.
      View in: PubMed
    6. Culver DA, Behr J, Belperio JA, Corte TJ, de Andrade JA, Flaherty KR, Gulati M, Huie TJ, Lancaster LH, Roman J, Ryerson CJ, Kim HJ. Patient Registries in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 Jul 15; 200(2):160-167. PMID: 31034241.
      View in: PubMed
    7. Palchevskiy V, Xue YY, Kern R, Weigt SS, Gregson AL, Song SX, Fishbein MC, Hogaboam CM, Sayah DM, Lynch JP, Keane MP, Brooks DG, Belperio JA. CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection. JCI Insight. 2019 May 14; 5. PMID: 31085832.
      View in: PubMed
    8. Weigt SS, Wang X, Palchevskiy V, Li X, Patel N, Ross DJ, Reynolds J, Shah PD, Danziger-Isakov LA, Sweet SC, Singer LG, Budev M, Palmer S, Belperio JA. Usefulness of gene expression profiling of bronchoalveolar lavage cells in acute lung allograft rejection. J Heart Lung Transplant. 2019 Aug; 38(8):845-855. PMID: 31122726.
      View in: PubMed
    9. Seki A, Anklesaria Z, Saggar R, Dodson MW, Schwab K, Liu MC, Charan Ashana D, Miller WD, Vangala S, DerHovanessian A, Channick R, Shaikh F, Belperio JA, Weigt SS, Lynch JP, Ross DJ, Sullivan L, Khanna D, Shapiro SS, Sager J, Gargani L, Stanziola A, Bossone E, Schraufnagel DE, Fishbein G, Xu H, Fishbein MC, Wallace WD, Saggar R. Capillary Proliferation in Systemic-Sclerosis-Related Pulmonary Fibrosis: Association with Pulmonary Hypertension. ACR Open Rheumatol. 2019 Mar; 1(1):26-36. PMID: 31777777.
      View in: PubMed
    10. Shino MY, DerHovanessian A, Sayah DM, Saggar R, Ying Xue Y, Ardehali A, Stripp BR, Ross DJ, Lynch JP, Elashoff RM, Weigt SS, Belperio JA. The Impact of Allograft CXCL9 during Respiratory Infection on the Risk of Chronic Lung Allograft Dysfunction. OBM Transplant. 2018; 2(4). PMID: 31414076.
      View in: PubMed
    11. Hoffmann-Vold AM, Weigt SS, Palchevskiy V, Volkmann E, Saggar R, Li N, Midtvedt Ø, Lund MB, Garen T, Fishbein MC, Ardehali A, Ross DJ, Ueland T, Aukrust P, Lynch JP, Elashoff RM, Molberg Ø, Belperio JA. Augmented concentrations of CX3CL1 are associated with interstitial lung disease in systemic sclerosis. PLoS One. 2018; 13(11):e0206545. PMID: 30457999.
      View in: PubMed
    12. Lynch JP, Derhovanessian A, Tazelaar H, Belperio JA. Granulomatosis with Polyangiitis (Wegener's Granulomatosis): Evolving Concepts in Treatment. Semin Respir Crit Care Med. 2018 08; 39(4):434-458. PMID: 30404111.
      View in: PubMed
    13. Hoffmann-Vold AM, Hesselstrand R, Fretheim H, Ueland T, Andreassen AK, Brunborg C, Palchevskiy V, Midtvedt Ø, Garen T, Aukrust P, Belperio JA, Molberg Ø. CCL21 as a Potential Serum Biomarker for Pulmonary Arterial Hypertension in Systemic Sclerosis. Arthritis Rheumatol. 2018 10; 70(10):1644-1653. PMID: 29687634.
      View in: PubMed
    14. Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system. JCI Insight. 2018 08 23; 3(16). PMID: 30135307.
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    15. Weigt SS, Wang X, Palchevskiy V, Patel N, Derhovanessian A, Shino MY, Sayah DM, Lynch JP, Saggar R, Ross DJ, Kubak BM, Ardehali A, Palmer S, Husain S, Belperio JA. Gene Expression Profiling of Bronchoalveolar Lavage Cells During Aspergillus Colonization of the Lung Allograft. Transplantation. 2018 06; 102(6):986-993. PMID: 29256975.
      View in: PubMed
    16. Schott C, Weigt SS, Turturice BA, Metwally A, Belperio J, Finn PW, Perkins DL. Bronchiolitis obliterans syndrome susceptibility and the pulmonary microbiome. J Heart Lung Transplant. 2018 09; 37(9):1131-1140. PMID: 29929823.
      View in: PubMed
    17. DerHovanessian A, Wallace WD, Lynch JP, Belperio JA, Weigt SS. Chronic Lung Allograft Dysfunction: Evolving Concepts and Therapies. Semin Respir Crit Care Med. 2018 04; 39(2):155-171. PMID: 29579768.
      View in: PubMed
    18. Belperio JA, Glanville AR. Lung Transplantation: Controversies and Evolving Concepts. Semin Respir Crit Care Med. 2018 04; 39(2):115-116. PMID: 29579764.
      View in: PubMed
    19. Clark NM, Weigt SS, Fishbein MC, Kubak B, Belperio JA, Lynch JP. Fungal Infections Complicating Lung Transplantation. Semin Respir Crit Care Med. 2018 04; 39(2):227-254. PMID: 29579774.
      View in: PubMed
    20. Walser TC, Jing Z, Tran LM, Lin YQ, Yakobian N, Wang G, Krysan K, Zhu LX, Sharma S, Lee MH, Belperio JA, Ooi AT, Gomperts BN, Shay JW, Larsen JE, Minna JD, Hong LS, Fishbein MC, Dubinett SM. Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells. Cancer Res. 2018 04 15; 78(8):1986-1999. PMID: 29431637.
      View in: PubMed
    21. Volkmann ER, Chung A, Saggar R, Belperio JA, Lynch JP. Pulmonary Hypertension Complicating Connective Tissue Disease. Semin Respir Crit Care Med. 2017 10; 38(5):619-635. PMID: 29032565.
      View in: PubMed
    22. Belperio J, Palmer SM, Weigt SS. Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction. Ann Am Thorac Soc. 2017 Sep; 14(Supplement_3):S242-S246. PMID: 28945471.
      View in: PubMed
    23. Weigt SS, Wang X, Palchevskiy V, Patel N, Derhovanessian A, Shino MY, Sayah DM, Gregson AL, Lynch JP, Saggar R, Ross DJ, Ardehali A, Elashoff D, Belperio JA. Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction. Ann Am Thorac Soc. 2017 09; 14(Suppl_3):S252. PMID: 28945470.
      View in: PubMed
    24. Schwingshackl A, Lopez B, Teng B, Luellen C, Lesage F, Belperio J, Olcese R, Waters CM. Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1030-L1046. PMID: 28839101.
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    25. Shino MY, Weigt SS, Li N, Derhovanessian A, Sayah DM, Saggar R, Huynh RH, Gregson AL, Ardehali A, Ross DJ, Lynch JP, Elashoff RM, Belperio JA. The Prognostic Importance of Bronchoalveolar Lavage Fluid CXCL9 During Minimal Acute Rejection on the Risk of Chronic Lung Allograft Dysfunction. Am J Transplant. 2018 01; 18(1):136-144. PMID: 28637080.
      View in: PubMed
    26. Sayah DM, Bradfield JS, Moriarty JM, Belperio JA, Lynch JP. Cardiac Involvement in Sarcoidosis: Evolving Concepts in Diagnosis and Treatment. Semin Respir Crit Care Med. 2017 08; 38(4):477-498. PMID: 28750462.
      View in: PubMed
    27. Shino MY, Weigt SS, Li N, Palchevskiy V, Derhovanessian A, Saggar R, Sayah DM, Huynh RH, Gregson AL, Fishbein MC, Ardehali A, Ross DJ, Lynch JP, Elashoff RM, Belperio JA. The prognostic importance of CXCR3 chemokine during organizing pneumonia on the risk of chronic lung allograft dysfunction after lung transplantation. PLoS One. 2017; 12(7):e0180281. PMID: 28686641.
      View in: PubMed
    28. Weigt SS, Palchevskiy V, Belperio JA. Inflammasomes and IL-1 biology in the pathogenesis of allograft dysfunction. J Clin Invest. 2017 Jun 01; 127(6):2022-2029. PMID: 28569730.
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    29. Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR. Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop. JCI Insight. 2017 May 04; 2(9). PMID: 28469087.
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    30. Weigt SS, Wang X, Palchevskiy V, Gregson AL, Patel N, DerHovanessian A, Shino MY, Sayah DM, Birjandi S, Lynch JP, Saggar R, Ardehali A, Ross DJ, Palmer SM, Elashoff D, Belperio JA. Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction. PLoS One. 2017; 12(1):e0169894. PMID: 28103284.
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    31. Allyn PR, Duffy EL, Humphries RM, Injean P, Weigt SS, Saggar R, Shino MY, Lynch JP, Ardehali A, Kubak B, Tseng CH, Belperio JA, Ross DJ, Gregson AL. Graft Loss and CLAD-Onset Is Hastened by Viral Pneumonia After Lung Transplantation. Transplantation. 2016 Nov; 100(11):2424-2431. PMID: 27467538.
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    32. Shino MY, Weigt SS, Li N, Derhovanessian A, Sayah DM, Huynh RH, Saggar R, Gregson AL, Ardehali A, Ross DJ, Lynch JP, Elashoff RM, Belperio JA. Impact of Allograft Injury Time of Onset on the Development of Chronic Lung Allograft Dysfunction After Lung Transplantation. Am J Transplant. 2017 05; 17(5):1294-1303. PMID: 27676455.
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    33. Kolaitis NA, Duffy E, Zhang A, Lo M, Barba DT, Chen M, Soriano T, Hu J, Nabili V, Saggar R, Sayah DM, DerHovanessian A, Shino MY, Lynch JP, Kubak BM, Ardehali A, Ross DJ, Belperio JA, Elashoff D, Saggar R, Weigt SS. Voriconazole increases the risk for cutaneous squamous cell carcinoma after lung transplantation. Transpl Int. 2017 Jan; 30(1):41-48. PMID: 27678492.
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    34. Sheth JS, Belperio JA, Fishbein MC, Kazerooni EA, Lagstein A, Murray S, Myers JL, Simon RH, Sisson TH, Sundaram B, White ES, Xia M, Zisman D, Flaherty KR. Utility of Transbronchial vs Surgical Lung Biopsy in the Diagnosis of Suspected Fibrotic Interstitial Lung Disease. Chest. 2017 02; 151(2):389-399. PMID: 27729263.
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    35. Reid GE, Lynch JP, Weigt S, Sayah D, Belperio JA, Grim SA, Clark NM. Herpesvirus Respiratory Infections in Immunocompromised Patients: Epidemiology, Management, and Outcomes. Semin Respir Crit Care Med. 2016 08; 37(4):603-30. PMID: 27486740.
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    36. Birjandi SZ, Palchevskiy V, Xue YY, Nunez S, Kern R, Weigt SS, Lynch JP, Chatila TA, Belperio JA. CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis. Am J Pathol. 2016 08; 186(8):2008-2020. PMID: 27317904.
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    37. Miele CH, Schwab K, Saggar R, Duffy E, Elashoff D, Tseng CH, Weigt S, Charan D, Abtin F, Johannes J, Derhovanessian A, Conklin J, Ghassemi K, Khanna D, Siddiqui O, Ardehali A, Hunter C, Kwon M, Biniwale R, Lo M, Volkmann E, Torres Barba D, Belperio JA, Sayah D, Mahrer T, Furst DE, Kafaja S, Clements P, Shino M, Gregson A, Kubak B, Lynch JP, Ross D, Saggar R. Lung Transplant Outcomes in Systemic Sclerosis with Significant Esophageal Dysfunction. A Comprehensive Single-Center Experience. Ann Am Thorac Soc. 2016 06; 13(6):793-802. PMID: 27078625.
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    38. Lynch JP, Huynh RH, Fishbein MC, Saggar R, Belperio JA, Weigt SS. Idiopathic Pulmonary Fibrosis: Epidemiology, Clinical Features, Prognosis, and Management. Semin Respir Crit Care Med. 2016 06; 37(3):331-57. PMID: 27231859.
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    39. DerHovanessian A, Todd JL, Zhang A, Li N, Mayalall A, Finlen Copeland CA, Shino M, Pavlisko EN, Wallace WD, Gregson A, Ross DJ, Saggar R, Lynch JP, Belperio J, Snyder LD, Palmer SM, Weigt SS. Validation and Refinement of Chronic Lung Allograft Dysfunction Phenotypes in Bilateral and Single Lung Recipients. Ann Am Thorac Soc. 2016 05; 13(5):627-35. PMID: 27144793.
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    40. Levine DJ, Glanville AR, Aboyoun C, Belperio J, Benden C, Berry GJ, Hachem R, Hayes D, Neil D, Reinsmoen NL, Snyder LD, Sweet S, Tyan D, Verleden G, Westall G, Yusen RD, Zamora M, Zeevi A. Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2016 Apr; 35(4):397-406. PMID: 27044531.
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    41. Kim HJ, Tashkin DP, Gjertson DW, Brown MS, Kleerup E, Chong S, Belperio JA, Roth MD, Abtin F, Elashoff R, Tseng CH, Khanna D, Goldin JG. Transitions to different patterns of interstitial lung disease in scleroderma with and without treatment. Ann Rheum Dis. 2016 Jul; 75(7):1367-71. PMID: 26757749.
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    42. Gregson AL, Hoji A, Injean P, Poynter ST, Briones C, Palchevskiy V, Weigt SS, Shino MY, Derhovanessian A, Sayah D, Saggar R, Ross D, Ardehali A, Lynch JP, Belperio JA. Altered Exosomal RNA Profiles in Bronchoalveolar Lavage from Lung Transplants with Acute Rejection. Am J Respir Crit Care Med. 2015 Dec 15; 192(12):1490-503. PMID: 26308930.
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    43. Belperio J, Horwich T, Abraham WT, Fonarow GC, Gorcsan J, Bersohn MM, Singh JP, Sonel A, Lee LY, Halilovic J, Kadish A, Shalaby AA. Inflammatory Mediators and Clinical Outcome in Patients With Advanced Heart Failure Receiving Cardiac Resynchronization Therapy. Am J Cardiol. 2016 Feb 15; 117(4):617-625. PMID: 26832186.
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    44. Ross DJ, Hough G, Hama S, Aboulhosn J, Belperio JA, Saggar R, Van Lenten BJ, Ardehali A, Eghbali M, Reddy S, Fogelman AM, Navab M. Proinflammatory high-density lipoprotein results from oxidized lipid mediators in the pathogenesis of both idiopathic and associated types of pulmonary arterial hypertension. Pulm Circ. 2015 Dec; 5(4):640-8. PMID: 26697171.
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    45. DerHovanessian A, Weigt SS, Palchevskiy V, Shino MY, Sayah DM, Gregson AL, Noble PW, Palmer SM, Fishbein MC, Kubak BM, Ardehali A, Ross DJ, Saggar R, Lynch JP, Elashoff RM, Belperio JA. The Role of TGF-ß in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome. Am J Transplant. 2016 Feb; 16(2):640-9. PMID: 26461171.
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    46. O'Beirne SL, Walsh SM, Fabre A, Reviriego C, Worrell JC, Counihan IP, Lumsden RV, Cramton-Barnes J, Belperio JA, Donnelly SC, Boylan D, Marchal-Sommé J, Kane R, Keane MP. CXCL9 Regulates TGF-ß1-Induced Epithelial to Mesenchymal Transition in Human Alveolar Epithelial Cells. J Immunol. 2015 Sep 15; 195(6):2788-96. PMID: 26268659.
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    47. Barnes JC, Lumsden RV, Worrell J, Counihan IP, O'Beirne SL, Belperio JA, Fabre A, Donnelly SC, Boylan D, Kane R, Keane MP. CXCR3 Requirement for the Interleukin-13-Mediated Up-Regulation of Interleukin-13Ra2 in Pulmonary Fibroblasts. Am J Respir Cell Mol Biol. 2015 Aug; 53(2):217-25. PMID: 25514189.
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    48. Lynch JP, Sayah DM, Belperio JA, Weigt SS. Lung transplantation for cystic fibrosis: results, indications, complications, and controversies. Semin Respir Crit Care Med. 2015 Apr; 36(2):299-320. PMID: 25826595.
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    49. Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch JP, Saggar R, Ardehali A, Ware LB, Christie JD, Belperio JA, Looney MR. Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 Feb 15; 191(4):455-63. PMID: 25485813.
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    50. Gregson AL, Wang X, Injean P, Weigt SS, Shino M, Sayah D, DerHovanessian A, Lynch JP, Ross DJ, Saggar R, Ardehali A, Li G, Elashoff R, Belperio JA. Staphylococcus via an interaction with the ELR+ CXC chemokine ENA-78 is associated with BOS. Am J Transplant. 2015 Mar; 15(3):792-9. PMID: 25683785.
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    51. Shino MY, Lynch Iii JP, Fishbein MC, McGraw C, Oyama J, Belperio JA, Saggar R. Sarcoidosis-associated pulmonary hypertension and lung transplantation for sarcoidosis. Semin Respir Crit Care Med. 2014 Jun; 35(3):362-71. PMID: 25007088.
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    52. Shahangian S, Shino MY, Barjaktarevic I, Susanto I, Belperio JA, Fishbein MC, Wang T. Interstitial lung disease in patients with hepatopulmonary syndrome: a case series and new observations. Lung. 2014 Jun; 192(3):421-7. PMID: 24682307.
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    53. Saggar R, Khanna D, Vaidya A, Derhovanessian A, Maranian P, Duffy E, Belperio JA, Weigt SS, Dua S, Shapiro SS, Goldin JG, Abtin F, Lynch JP, Ross DJ, Forfia PR, Saggar R. Changes in right heart haemodynamics and echocardiographic function in an advanced phenotype of pulmonary hypertension and right heart dysfunction associated with pulmonary fibrosis. Thorax. 2014 Feb; 69(2):123-9. PMID: 24431095.
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    54. Shino MY, Weigt SS, Li N, Palchevskiy V, Derhovanessian A, Saggar R, Sayah DM, Gregson AL, Fishbein MC, Ardehali A, Ross DJ, Lynch JP, Elashoff RM, Belperio JA. CXCR3 ligands are associated with the continuum of diffuse alveolar damage to chronic lung allograft dysfunction. Am J Respir Crit Care Med. 2013 Nov 01; 188(9):1117-25. PMID: 24063316.
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    55. Shino MY, Lynch JP, Saggar R, Abtin F, Belperio JA, Saggar R. Pulmonary hypertension complicating interstitial lung disease and COPD. Semin Respir Crit Care Med. 2013 Oct; 34(5):600-19. PMID: 24037628.
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    56. Lynch JP, Belperio JA, Saggar R, Fishbein MC, Saggar R. Pulmonary hypertension complicating connective tissue disease. Semin Respir Crit Care Med. 2013 Oct; 34(5):581-99. PMID: 24037627.
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    57. Yadlapati A, Lynch JP, Saggar R, Ross D, Belperio JA, Weigt S, Ardehali A, Grogan T, Yang EH, Aboulhosn J. Preoperative cardiac variables of diastolic dysfunction and clinical outcomes in lung transplant recipients. J Transplant. 2013; 2013:391620. PMID: 24163757.
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    58. Clark NM, Lynch JP, Sayah D, Belperio JA, Fishbein MC, Weigt SS. DNA viral infections complicating lung transplantation. Semin Respir Crit Care Med. 2013 Jun; 34(3):380-404. PMID: 23821512.
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    59. Belperio JA, Christie JD. Lung transplantation. Semin Respir Crit Care Med. 2013 Jun; 34(3):273-4. PMID: 23821501.
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    60. Weigt SS, DerHovanessian A, Wallace WD, Lynch JP, Belperio JA. Bronchiolitis obliterans syndrome: the Achilles' heel of lung transplantation. Semin Respir Crit Care Med. 2013 Jun; 34(3):336-51. PMID: 23821508.
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    61. Weigt SS, Copeland CAF, Derhovanessian A, Shino MY, Davis WA, Snyder LD, Gregson AL, Saggar R, Lynch JP, Ross DJ, Ardehali A, Elashoff RM, Palmer SM, Belperio JA. Colonization with small conidia Aspergillus species is associated with bronchiolitis obliterans syndrome: a two-center validation study. Am J Transplant. 2013 Apr; 13(4):919-927. PMID: 23398785.
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    62. Gregson AL, Wang X, Weigt SS, Palchevskiy V, Lynch JP, Ross DJ, Kubak BM, Saggar R, Fishbein MC, Ardehali A, Li G, Elashoff R, Belperio JA. Interaction between Pseudomonas and CXC chemokines increases risk of bronchiolitis obliterans syndrome and death in lung transplantation. Am J Respir Crit Care Med. 2013 Mar 01; 187(5):518-26. PMID: 23328531.
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    63. DeNicola MM, Weigt SS, Belperio JA, Reed EF, Ross DJ, Wallace WD. Pathologic findings in lung allografts with anti-HLA antibodies. J Heart Lung Transplant. 2013 Mar; 32(3):326-32. PMID: 23313559.
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    64. Wang T, Derhovanessian A, De Cruz S, Belperio JA, Deng JC, Hoo GS. Subsequent infections in survivors of sepsis: epidemiology and outcomes. J Intensive Care Med. 2014 Mar-Apr; 29(2):87-95. PMID: 23753224.
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    65. Saggar R, Khanna D, Shapiro S, Furst DE, Maranian P, Clements P, Abtin F, Dua S, Belperio J, Saggar R. Brief report: effect of ambrisentan treatment on exercise-induced pulmonary hypertension in systemic sclerosis: a prospective single-center, open-label pilot study. Arthritis Rheum. 2012 Dec; 64(12):4072-7. PMID: 22777623.
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    66. Shino MY, Rabbani S, Belperio JA, Lynch JP, Weigt SS. Neurofibromatosis-associated diffuse lung disease: case report. Semin Respir Crit Care Med. 2012 Oct; 33(5):572-5. PMID: 23001809.
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    67. Lynch JP, Weigt SS, DerHovanessian A, Fishbein MC, Gutierrez A, Belperio JA. Obliterative (constrictive) bronchiolitis. Semin Respir Crit Care Med. 2012 Oct; 33(5):509-32. PMID: 23001805.
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    68. Shino MY, Weigt SS, Saggar R, Elashoff D, Derhovanessian A, Gregson AL, Saggar R, Reed EF, Kubak BM, Lynch JP, Belperio JA, Ardehali A, Ross DJ. Usefulness of immune monitoring in lung transplantation using adenosine triphosphate production in activated lymphocytes. J Heart Lung Transplant. 2012 Sep; 31(9):996-1002. PMID: 22884386.
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    69. Diamond JM, Meyer NJ, Feng R, Rushefski M, Lederer DJ, Kawut SM, Lee JC, Cantu E, Shah RJ, Lama VN, Bhorade S, Crespo M, Demissie E, Sonett J, Wille K, Orens J, Weinacker A, Weill D, Arcasoy S, Shah PD, Belperio JA, Wilkes D, Ware LB, Palmer SM, Christie JD. Variation in PTX3 is associated with primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2012 Sep 15; 186(6):546-52. PMID: 22822025.
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    70. Shah RJ, Bellamy SL, Localio AR, Wickersham N, Diamond JM, Weinacker A, Lama VN, Bhorade S, Belperio JA, Crespo M, Demissie E, Kawut SM, Wille KM, Lederer DJ, Lee JC, Palmer SM, Orens J, Reynolds J, Shah A, Wilkes DS, Ware LB, Christie JD. A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation. J Heart Lung Transplant. 2012 Sep; 31(9):942-9. PMID: 22694851.
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    71. Ross DJ, Strieter RM, Fishbein MC, Ardehali A, Belperio JA. Type I immune response cytokine-chemokine cascade is associated with pulmonary arterial hypertension. J Heart Lung Transplant. 2012 Aug; 31(8):865-73. PMID: 22658713.
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    72. Weigt SS, Derhovanessian A, Liao E, Hu S, Gregson AL, Kubak BM, Saggar R, Saggar R, Plachevskiy V, Fishbein MC, Lynch JP, Ardehali A, Ross DJ, Wang HJ, Elashoff RM, Belperio JA. CXCR3 chemokine ligands during respiratory viral infections predict lung allograft dysfunction. Am J Transplant. 2012 Feb; 12(2):477-84. PMID: 22152000.
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    74. Rehan VK, Sakurai R, Li Y, Karadag A, Corral J, Bellusci S, Xue YY, Belperio J, Torday JS. Effects of maternal food restriction on offspring lung extracellular matrix deposition and long term pulmonary function in an experimental rat model. Pediatr Pulmonol. 2012 Feb; 47(2):162-71. PMID: 22058072.
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    81. Palchevskiy V, Hashemi N, Weigt SS, Xue YY, Derhovanessian A, Keane MP, Strieter RM, Fishbein MC, Deng JC, Lynch JP, Elashoff R, Belperio JA. Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis. Fibrogenesis Tissue Repair. 2011 Apr 04; 4:10. PMID: 21463523.
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    82. Martinu T, Kinnier CV, Gowdy KM, Kelly FL, Snyder LD, Jiang D, Foster WM, Garantziotis S, Belperio JA, Noble PW, Palmer SM. Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3. J Heart Lung Transplant. 2011 Jun; 30(6):717-25. PMID: 21444213.
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    83. Nakajima T, Palchevsky V, Perkins DL, Belperio JA, Finn PW. Lung transplantation: infection, inflammation, and the microbiome. Semin Immunopathol. 2011 Mar; 33(2):135-56. PMID: 21271250.
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    84. Saggar R, Khanna D, Furst DE, Shapiro S, Maranian P, Belperio JA, Chauhan N, Clements P, Gorn A, Weigt SS, Ross D, Lynch JP, Saggar R. Exercise-induced pulmonary hypertension associated with systemic sclerosis: four distinct entities. Arthritis Rheum. 2010 Dec; 62(12):3741-50. PMID: 20722025.
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    85. Lee C, Suh RD, Krishnam MS, Lai CK, Fishbein MC, Wallace WD, Chen A, Saggar R, Saggar R, Belperio JA, Ardehali A, Ross DJ. Recurrent pulmonary capillary hemangiomatosis after bilateral lung transplantation. J Thorac Imaging. 2010 Aug; 25(3):W89-92. PMID: 20445464.
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    86. Gregson AL, Hoji A, Palchevskiy V, Hu S, Weigt SS, Liao E, Derhovanessian A, Saggar R, Song S, Elashoff R, Yang OO, Belperio JA. Protection against bronchiolitis obliterans syndrome is associated with allograft CCR7+ CD45RA- T regulatory cells. PLoS One. 2010 Jun 29; 5(6):e11354. PMID: 20613873.
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    88. Belperio JA, Orens JB. Evolving concepts and controversies in lung transplantation. Semin Respir Crit Care Med. 2010 Apr; 31(2):97-8. PMID: 20354922.
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    91. Wang TF, Wang T, Altman R, Eshaghian P, Lynch JP, Ross DJ, Belperio JA, Weigt SS, Saggar R, Gregson A, Kubak B, Saggar R. Periostitis secondary to prolonged voriconazole therapy in lung transplant recipients. Am J Transplant. 2009 Dec; 9(12):2845-50. PMID: 19845595.
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    92. van der Veen BS, Petersen AH, Belperio JA, Satchell SC, Mathieson PW, Molema G, Heeringa P. Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis. Clin Exp Immunol. 2009 Oct; 158(1):143-53. PMID: 19737241.
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    96. Shahangian A, Chow EK, Tian X, Kang JR, Ghaffari A, Liu SY, Belperio JA, Cheng G, Deng JC. Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. J Clin Invest. 2009 Jul; 119(7):1910-20. PMID: 19487810.
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    97. Nickerson DW, Presson AP, Weigt SS, Gregson AL, Belperio JA, Gomperts BN. Quantification of cytokeratin 5 mRNA expression in the circulation of healthy human subjects and after lung transplantation. PLoS One. 2009 Jun 16; 4(6):e5925. PMID: 19529775.
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    98. Weigt SS, Elashoff RM, Huang C, Ardehali A, Gregson AL, Kubak B, Fishbein MC, Saggar R, Keane MP, Saggar R, Lynch JP, Zisman DA, Ross DJ, Belperio JA. Aspergillus colonization of the lung allograft is a risk factor for bronchiolitis obliterans syndrome. Am J Transplant. 2009 Aug; 9(8):1903-11. PMID: 19459819.
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    99. Busuttil A, Weigt SS, Keane MP, Xue YY, Palchevskiy V, Burdick MD, Huang C, Zisman DA, Fishbein M, Lynch JP, Strieter RM, Elashoff RM, Belperio JA. CXCR3 ligands are augmented during the pathogenesis of pulmonary sarcoidosis. Eur Respir J. 2009 Sep; 34(3):676-86. PMID: 19386686.
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    102. Belperio JA, Ardehali A. Chemokines and transplant vasculopathy. Circ Res. 2008 Aug 29; 103(5):454-66. PMID: 18757833.
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    104. Nathan SD, Shlobin OA, Barnett SD, Saggar R, Belperio JA, Ross DJ, Ahmad S, Saggar R, Libre E, Lynch JP, Zisman DA. Right ventricular systolic pressure by echocardiography as a predictor of pulmonary hypertension in idiopathic pulmonary fibrosis. Respir Med. 2008 Sep; 102(9):1305-10. PMID: 18619825.
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    106. Sarafian T, Montes C, Harui A, Beedanagari SR, Kiertscher S, Stripecke R, Hossepian D, Kitchen C, Kern R, Belperio J, Roth MD. Clarifying CB2 receptor-dependent and independent effects of THC on human lung epithelial cells. Toxicol Appl Pharmacol. 2008 Sep 15; 231(3):282-90. PMID: 18556036.
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    107. Gregson AL, Hoji A, Saggar R, Ross DJ, Kubak BM, Jamieson BD, Weigt SS, Lynch JP, Ardehali A, Belperio JA, Yang OO. Bronchoalveolar immunologic profile of acute human lung transplant allograft rejection. Transplantation. 2008 Apr 15; 85(7):1056-9. PMID: 18408589.
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    108. Schnickel GT, Bastani S, Hsieh GR, Shefizadeh A, Bhatia R, Fishbein MC, Belperio J, Ardehali A. Combined CXCR3/CCR5 blockade attenuates acute and chronic rejection. J Immunol. 2008 Apr 01; 180(7):4714-21. PMID: 18354195.
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    109. Zisman DA, Karlamangla AS, Kawut SM, Shlobin OA, Saggar R, Ross DJ, Schwarz MI, Belperio JA, Ardehali A, Lynch JP, Nathan SD. Validation of a method to screen for pulmonary hypertension in advanced idiopathic pulmonary fibrosis. Chest. 2008 Mar; 133(3):640-5. PMID: 18198245.
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    110. Lynch JP, Fishbein MC, Saggar R, Zisman DA, Belperio JA. Idiopathic pulmonary fibrosis. Expert Rev Respir Med. 2007 Dec; 1(3):377-89. PMID: 20477177.
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    113. Hong KM, Belperio JA, Keane MP, Burdick MD, Strieter RM. Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma. J Biol Chem. 2007 Aug 03; 282(31):22910-20. PMID: 17556364.
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    114. Gomperts BN, Belperio JA, Fishbein MC, Keane MP, Burdick MD, Strieter RM. Keratinocyte growth factor improves repair in the injured tracheal epithelium. Am J Respir Cell Mol Biol. 2007 Jul; 37(1):48-56. PMID: 17332441.
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    116. Mehrad B, Burdick MD, Zisman DA, Keane MP, Belperio JA, Strieter RM. Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease. Biochem Biophys Res Commun. 2007 Feb 02; 353(1):104-8. PMID: 17174272.
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    117. Keane MP, Strieter RM, Lynch JP, Belperio JA. Inflammation and angiogenesis in fibrotic lung disease. Semin Respir Crit Care Med. 2006 Dec; 27(6):589-99. PMID: 17195136.
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    118. Pan J, Mestas J, Burdick MD, Phillips RJ, Thomas GV, Reckamp K, Belperio JA, Strieter RM. Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis. Mol Cancer. 2006 Nov 03; 5:56. PMID: 17083723.
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    120. Belperio JA, Keane MP, Lynch JP, Strieter RM. The role of cytokines during the pathogenesis of ventilator-associated and ventilator-induced lung injury. Semin Respir Crit Care Med. 2006 Aug; 27(4):350-64. PMID: 16909369.
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    121. Zhai Y, Shen XD, Hancock WW, Gao F, Qiao B, Lassman C, Belperio JA, Strieter RM, Busuttil RW, Kupiec-Weglinski JW. CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury. J Immunol. 2006 May 15; 176(10):6313-22. PMID: 16670343.
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    122. Strieter RM, Burdick MD, Mestas J, Gomperts B, Keane MP, Belperio JA. Cancer CXC chemokine networks and tumour angiogenesis. Eur J Cancer. 2006 Apr; 42(6):768-78. PMID: 16510280.
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    123. Terada T, Zhang K, Belperio J, Londhe V, Saxon A. A chimeric human-cat Fcgamma-Fel d1 fusion protein inhibits systemic, pulmonary, and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1, the major cat allergen. Clin Immunol. 2006 Jul; 120(1):45-56. PMID: 16473552.
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    125. Gomperts BN, Belperio JA, Rao PN, Randell SH, Fishbein MC, Burdick MD, Strieter RM. Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury. J Immunol. 2006 Feb 01; 176(3):1916-27. PMID: 16424223.
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    127. Londhe VA, Belperio JA, Keane MP, Burdick MD, Xue YY, Strieter RM. CXCR2/CXCR2 ligand biological axis impairs alveologenesis during dsRNA-induced lung inflammation in mice. Pediatr Res. 2005 Nov; 58(5):919-26. PMID: 16183824.
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    129. El-Sawy T, Belperio JA, Strieter RM, Remick DG, Fairchild RL. Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection. Circulation. 2005 Jul 19; 112(3):320-31. PMID: 15998678.
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    133. Phillips RJ, Mestas J, Gharaee-Kermani M, Burdick MD, Sica A, Belperio JA, Keane MP, Strieter RM. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. J Biol Chem. 2005 Jun 10; 280(23):22473-81. PMID: 15802268.
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    135. Keane MP, Strieter RM, Belperio JA. Mechanisms and mediators of pulmonary fibrosis. Crit Rev Immunol. 2005; 25(6):429-63. PMID: 16390322.
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    138. Ross DJ, Cole AM, Yoshioka D, Park AK, Belperio JA, Laks H, Strieter RM, Lynch JP, Kubak B, Ardehali A, Ganz T. Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation. Transplantation. 2004 Oct 27; 78(8):1222-4. PMID: 15502724.
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    139. Burdick MD, Murray LA, Keane MP, Xue YY, Zisman DA, Belperio JA, Strieter RM. CXCL11 attenuates bleomycin-induced pulmonary fibrosis via inhibition of vascular remodeling. Am J Respir Crit Care Med. 2005 Feb 01; 171(3):261-8. PMID: 15502109.
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    142. Addison CL, Belperio JA, Burdick MD, Strieter RM. Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis. BMC Cancer. 2004 Jun 23; 4:28. PMID: 15214968.
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    143. Whiting D, Hsieh G, Yun JJ, Banerji A, Yao W, Fishbein MC, Belperio J, Strieter RM, Bonavida B, Ardehali A. Chemokine monokine induced by IFN-gamma/CXC chemokine ligand 9 stimulates T lymphocyte proliferation and effector cytokine production. J Immunol. 2004 Jun 15; 172(12):7417-24. PMID: 15187119.
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    144. Strieter RM, Belperio JA, Phillips RJ, Keane MP. CXC chemokines in angiogenesis of cancer. Semin Cancer Biol. 2004 Jun; 14(3):195-200. PMID: 15246055.
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    145. Belperio JA, Phillips RJ, Burdick MD, Lutz M, Keane M, Strieter R. The SDF-1/CXCL 12/CXCR4 biological axis in non-small cell lung cancer metastases. Chest. 2004 May; 125(5 Suppl):156S. PMID: 15136483.
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    146. Keane MP, Burdick MD, Xue YY, Lutz M, Belperio JA, Strieter RM. The chemokine receptor, CXCR2, mediates the tumorigenic effects of ELR+ CXC chemokines. Chest. 2004 May; 125(5 Suppl):133S. PMID: 15136463.
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    147. Sue RD, Belperio JA, Burdick MD, Murray LA, Xue YY, Dy MC, Kwon JJ, Keane MP, Strieter RM. CXCR2 is critical to hyperoxia-induced lung injury. J Immunol. 2004 Mar 15; 172(6):3860-8. PMID: 15004193.
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    148. Keane MP, Belperio JA, Xue YY, Burdick MD, Strieter RM. Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer. J Immunol. 2004 Mar 01; 172(5):2853-60. PMID: 14978086.
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    150. Belperio JA, Keane MP, Burdick MD, Lynch JP, Zisman DA, Xue YY, Li K, Ardehali A, Ross DJ, Strieter RM. Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection. J Immunol. 2003 Nov 01; 171(9):4844-52. PMID: 14568964.
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    151. Belperio JA, Lake K, Tazelaar H, Keane MP, Strieter RM, Lynch JP. Bronchiolitis obliterans syndrome complicating lung or heart-lung transplantation. Semin Respir Crit Care Med. 2003 Oct; 24(5):499-530. PMID: 16088570.
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    154. Strieter RM, Belperio JA, Keane MP. Host innate defenses in the lung: the role of cytokines. Curr Opin Infect Dis. 2003 Jun; 16(3):193-8. PMID: 12821807.
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    155. Kao J, Kobashigawa J, Fishbein MC, MacLellan WR, Burdick MD, Belperio JA, Strieter RM. Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease. Circulation. 2003 Apr 22; 107(15):1958-61. PMID: 12695288.
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    156. Phillips RJ, Burdick MD, Lutz M, Belperio JA, Keane MP, Strieter RM. The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med. 2003 Jun 15; 167(12):1676-86. PMID: 12626353.
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    157. Strieter RM, Burdick MD, Belperio JA, Keane MP. Measurement of chemokines at the protein level in tissue. Methods Mol Med. 2003; 78:377-88. PMID: 12825287.
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    158. Strieter RM, Belperio JA, Keane MP. CXC chemokines in angiogenesis related to pulmonary fibrosis. Chest. 2002 Dec; 122(6 Suppl):298S-301S. PMID: 12475804.
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    159. Belperio JA, Keane MP, Burdick MD, Londhe V, Xue YY, Li K, Phillips RJ, Strieter RM. Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury. J Clin Invest. 2002 Dec; 110(11):1703-16. PMID: 12464676.
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    160. Keane MP, Donnelly SC, Belperio JA, Goodman RB, Dy M, Burdick MD, Fishbein MC, Strieter RM. Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome. J Immunol. 2002 Dec 01; 169(11):6515-21. PMID: 12444162.
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    162. Yun JJ, Fischbein MP, Whiting D, Irie Y, Fishbein MC, Burdick MD, Belperio J, Strieter RM, Laks H, Berliner JA, Ardehali A. The role of MIG/CXCL9 in cardiac allograft vasculopathy. Am J Pathol. 2002 Oct; 161(4):1307-13. PMID: 12368204.
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