Andreas Schwingshackl

Title(s)Associate Professor-in-Residence, Pediatrics
SchoolMedicine
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    Trek-1 Potassium Channels Protect from Hyperoxia-induced Acute Lung Injury
    NIH R01HL146821Mar 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    The Role of 2-Pore Domain Potassium Channels in Acute Lung Injury.
    NIH K08HL118118Feb 1, 2014 - May 31, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cell saver blood transfusions may be associated with a decrease in inflammation and improved outcome measures in pediatric cardiac surgery patients. Perfusion. 2022 Apr 12; 2676591221078420. Martinez MJ, Schwingshackl A, Romero T, Roach GD, Belperio JA, Federman MD. PMID: 35411827.
      View in: PubMed   Mentions: 1     Fields:    
    2. Beyond the Alveolar Epithelium: Plasma Soluble Receptor for Advanced Glycation End Products Is Associated With Oxygenation Impairment, Mortality, and Extrapulmonary Organ Failure in Children With Acute Respiratory Distress Syndrome. Crit Care Med. 2022 05 01; 50(5):837-847. Lim MJ, Zinter MS, Chen L, Wong KMY, Bhalla A, Gala K, Guglielmo M, Alkhouli M, Huard LL, Hanudel MR, Vangala S, Schwingshackl A, Matthay M, Sapru A. PMID: 34678846; PMCID: PMC9035468.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Pediatric interfacility transport effects on mortality and length of stay. World J Pediatr. 2021 Aug; 17(4):400-408. Shinozaki RM, Schwingshackl A, Srivastava N, Grogan T, Kelly RB. PMID: 34319538; PMCID: PMC8363522.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. BK Channels Regulate LPS-induced CCL-2 Release from Human Pulmonary Endothelial Cells. Am J Respir Cell Mol Biol. 2021 02; 64(2):224-234. Zyrianova T, Lopez B, Liao A, Gu C, Wong L, Ottolia M, Olcese R, Schwingshackl A. PMID: 33217242; PMCID: PMC7874395.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    5. K2P2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury. Sci Rep. 2020 12 15; 10(1):22011. Zyrianova T, Lopez B, Olcese R, Belperio J, Waters CM, Wong L, Nguyen V, Talapaneni S, Schwingshackl A. PMID: 33319831; PMCID: PMC7738539.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    6. TREK-1 protects the heart against ischemia-reperfusion-induced injury and from adverse remodeling after myocardial infarction. Pflugers Arch. 2019 10; 471(10):1263-1272. Kamatham S, Waters CM, Schwingshackl A, Mancarella S. PMID: 31511966; PMCID: PMC8996126.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    7. Apoptosis signal-regulating kinase-1 promotes inflammasome priming in macrophages. Am J Physiol Lung Cell Mol Physiol. 2019 03 01; 316(3):L418-L427. Immanuel CN, Teng B, Dong B, Gordon EM, Kennedy JA, Luellen C, Schwingshackl A, Cormier SA, Fitzpatrick EA, Waters CM. PMID: 30628485; PMCID: PMC6459294.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1030-L1046. Schwingshackl A, Lopez B, Teng B, Luellen C, Lesage F, Belperio J, Olcese R, Waters CM. PMID: 28839101; PMCID: PMC5814704.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    9. Editorial: ARDS: Reaching for the Horizon. Front Pediatr. 2017; 5:100. McGuire JK, Schwingshackl A, Anand KJS. PMID: 28555176; PMCID: PMC5430045.
      View in: PubMed   Mentions:
    10. Editorial: Work-Life Balance: Essential or Ephemeral? Front Pediatr. 2017; 5:108. Schwingshackl A, Anand KJS. PMID: 28540286; PMCID: PMC5423898.
      View in: PubMed   Mentions:
    11. The role of stretch-activated ion channels in acute respiratory distress syndrome: finally a new target? Am J Physiol Lung Cell Mol Physiol. 2016 09 01; 311(3):L639-52. Schwingshackl A. PMID: 27521425; PMCID: PMC5142209.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    12. Prolonged Glucocorticoid Treatment in ARDS: Impact on Intensive Care Unit-Acquired Weakness. Front Pediatr. 2016; 4:69. Meduri GU, Schwingshackl A, Hermans G. PMID: 27532030; PMCID: PMC4969316.
      View in: PubMed   Mentions: 8  
    13. Rationale for Prolonged Glucocorticoid Use in Pediatric ARDS: What the Adults Can Teach Us. Front Pediatr. 2016; 4:58. Schwingshackl A, Meduri GU. PMID: 27379217; PMCID: PMC4906037.
      View in: PubMed   Mentions: 7  
    14. Plasma Biomarker Analysis in Pediatric ARDS: Generating Future Framework from a Pilot Randomized Control Trial of Methylprednisolone: A Framework for Identifying Plasma Biomarkers Related to Clinical Outcomes in Pediatric ARDS. Front Pediatr. 2016; 4:31. Kimura D, Saravia J, Rovnaghi CR, Meduri GU, Schwingshackl A, Cormier SA, Anand KJ. PMID: 27066464; PMCID: PMC4815896.
      View in: PubMed   Mentions: 7  
    15. Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 01; 310(5):L393-402. Andrews K, Ghosh MC, Schwingshackl A, Rapalo G, Luellen C, Waters CM, Fitzpatrick EA. PMID: 26719148; PMCID: PMC4773842.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    16. Regulation of inflammatory biomarkers by intravenous methylprednisolone in pediatric ARDS patients: Results from a double-blind, placebo-controlled randomized pilot trial. Cytokine. 2016 Jan; 77:63-71. Schwingshackl A, Kimura D, Rovnaghi CR, Saravia JS, Cormier SA, Teng B, West AN, Meduri UG, Anand KJ. PMID: 26545141; PMCID: PMC4666843.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    17. Corticosteroids in pediatric ARDS: all cards on the table. Intensive Care Med. 2015 Nov; 41(11):2036-7. Schwingshackl A, Meduri GU, Kimura D, Cormier SA, Anand KJ. PMID: 26359160; PMCID: PMC4584398.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. TREK-1 Regulates Cytokine Secretion from Cultured Human Alveolar Epithelial Cells Independently of Cytoskeletal Rearrangements. PLoS One. 2015; 10(5):e0126781. Schwingshackl A, Roan E, Teng B, Waters CM. PMID: 26001192; PMCID: PMC4441361.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    19. Inverse Relationship between Cardio-Ankle Vascular Index and Body Mass Index in Healthy Children. J Pediatr. 2015 Aug; 167(2):361-365.e1. Philip R, Alpert BS, Schwingshackl A, Huang X, Blakely D, Rovnaghi CR, Tran QT, Velasquez A, Arevalo A, Anand KJ. PMID: 26003881.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    20. Double-blind, placebo-controlled pilot randomized trial of methylprednisolone infusion in pediatric acute respiratory distress syndrome. Pediatr Crit Care Med. 2015 Mar; 16(3):e74-81. Drago BB, Kimura D, Rovnaghi CR, Schwingshackl A, Rayburn M, Meduri GU, Anand KJ. PMID: 25634565.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    21. Pulmonary epithelial barrier function: some new players and mechanisms. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15; 308(8):L731-45. Brune K, Frank J, Schwingshackl A, Finigan J, Sidhaye VK. PMID: 25637609; PMCID: PMC4747906.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    22. Deficiency of the two-pore-domain potassium channel TREK-1 promotes hyperoxia-induced lung injury. Crit Care Med. 2014 Nov; 42(11):e692-701. Schwingshackl A, Teng B, Makena P, Ghosh M, Sinclair SE, Luellen C, Balasz L, Rovnaghi C, Bryan RM, Lloyd EE, Fitzpatrick E, Saravia JS, Cormier SA, Waters CM. PMID: 25126877; PMCID: PMC4199872.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    23. The fallacy of chasing after work-life balance. Front Pediatr. 2014; 2:26. Schwingshackl A. PMID: 24745004; PMCID: PMC3978284.
      View in: PubMed   Mentions: 3  
    24. The 2-pore domain potassium channel TREK-1 regulates stretch-induced detachment of alveolar epithelial cells. PLoS One. 2014; 9(2):e89429. Roan E, Waters CM, Teng B, Ghosh M, Schwingshackl A. PMID: 24586773; PMCID: PMC3929719.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    25. Regulation of Monocyte Chemotactic Protein-1 secretion by the Two-Pore-Domain Potassium (K2P) channel TREK-1 in human alveolar epithelial cells. Am J Transl Res. 2013; 5(5):530-42. Schwingshackl A, Teng B, Ghosh M, Waters CM. PMID: 23977412; PMCID: PMC3745440.
      View in: PubMed   Mentions: 16  
    26. Insulin-like growth factor-I stimulates differentiation of ATII cells to ATI-like cells through activation of Wnt5a. Am J Physiol Lung Cell Mol Physiol. 2013 Aug 01; 305(3):L222-8. Ghosh MC, Gorantla V, Makena PS, Luellen C, Sinclair SE, Schwingshackl A, Waters CM. PMID: 23709620; PMCID: PMC3743013.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    27. Regulation of interleukin-6 secretion by the two-pore-domain potassium channel Trek-1 in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15; 304(4):L276-86. Schwingshackl A, Teng B, Ghosh M, Lim KG, Tigyi G, Narayanan D, Jaggar JH, Waters CM. PMID: 23275623; PMCID: PMC3567358.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    28. Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 01; 302(1):L93-L102. Schwingshackl A, Teng B, Ghosh M, West AN, Makena P, Gorantla V, Sinclair SE, Waters CM. PMID: 21949155; PMCID: PMC3349376.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    29. Expression and activity of matrix metallo proteinases 2 and 9 and their inhibitors in rat lungs during the perinatal period and in diaphragmatic hernia. Exp Lung Res. 2003 Jun; 29(4):261-76. Lemke RP, Zhang W, Balcerazak D, Kobayashi K, Schwingshackl A, Cheung PY, Dixon WT, Baracos VE, Greer JJ. PMID: 12746050.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    30. Mast cells express chloride channels of the ClC family. Inflamm Res. 2002 Sep; 51(9):451-6. Kulka M, Schwingshackl A, Befus AD. PMID: 12365718.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    31. Nitric oxide activates ATP-dependent K+ channels in human eosinophils. J Leukoc Biol. 2002 May; 71(5):807-12. Schwingshackl A, Moqbel R, Duszyk M. PMID: 11994505.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    32. Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells. J Allergy Clin Immunol. 2000 Sep; 106(3):537-45. Vliagoftis H, Schwingshackl A, Milne CD, Duszyk M, Hollenberg MD, Wallace JL, Befus AD, Moqbel R. PMID: 10984375.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    33. Involvement of ion channels in human eosinophil respiratory burst. J Allergy Clin Immunol. 2000 Aug; 106(2):272-9. Schwingshackl A, Moqbel R, Duszyk M. PMID: 10932070.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    34. Human eosinophils release matrix metalloproteinase-9 on stimulation with TNF-alpha. J Allergy Clin Immunol. 1999 Nov; 104(5):983-9. Schwingshackl A, Duszyk M, Brown N, Moqbel R. PMID: 10550743.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
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