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Andreas Schwingshackl

Title(s)Associate Professor, Pediatrics
SchoolMedicine
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    The Role of TREK-1 potassium channels in ARDS
    NIH R01HL175464Aug 16, 2024 - Jun 30, 2029
    Role: Principal Investigator
    Trek-1 Potassium Channels Protect from Hyperoxia-induced Acute Lung Injury
    NIH R01HL146821Mar 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    The Role of 2-Pore Domain Potassium Channels in Acute Lung Injury.
    NIH K08HL118118Feb 1, 2014 - May 31, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The four voltage-sensing domains of T-type calcium channels activate near the resting membrane potential. Nat Commun. 2026 May 16. Angelini M, McVicar M, Maxfield S, Sokolowski M, Narang S, Scranton K, Yasarbas SS, Savalli N, John SA, Schwingshackl A, Neely A, Pantazis A, Ottolia M, Olcese R. PMID: 42143043.
      View in: PubMed   Mentions:    Fields:    
    2. Plasma Heparan Sulfate Structural Variation and Phenotypic Heterogeneity in Pediatric Acute Respiratory Distress Syndrome. Res Sq. 2026 May 04. Sallee CJ, Maddux AB, Hippensteel JA, Markovic D, Wang Z, Liu J, Oshima K, Richter RP, Schwingshackl A, Mourani PM, Elashoff D, Schmidt EP, Sapru A. PMID: 42147147; PMCID: PMC13174808.
      View in: PubMed   Mentions:
    3. The mechanism of action of digoxin requires the sodium-dependent inactivation of the sodium-calcium exchanger. Sci Adv. 2025 Dec 19; 11(51):eady9596. Scranton K, John S, Angelini M, Zhang R, Schwingshackl A, Goldhaber JI, Olcese R, Ottolia M. PMID: 41406234; PMCID: PMC12710698.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. C6 peptide blockade of Hv1 channels inhibits neutrophil migration into the lungs to suppress Pseudomonas aeruginosa-induced acute lung injury. Respir Res. 2025 Nov 28; 26(1):339. Zhao R, Lopez B, Majumder N, Kasparian A, Hua P, Dai H, Nayak M, Zyrianova T, Taylor C, Ding Y, Sallee CJ, Sapru A, Goldstein SAN, Schwingshackl A. PMID: 41316271; PMCID: PMC12661846.
      View in: PubMed   Mentions:    Fields:    
    5. Role of the two-pore domain potassium channel TREK-1 in hyperoxia- and mechanical stretch-induced alveolar epithelial injury. Am J Physiol Lung Cell Mol Physiol. 2026 Jan 01; 330(1):L49-L65. Majumder N, Lopez B, Kasparian A, Taylor J, Chatterjee K, Zhong H, Fabrizio M, Angelini M, Zyrianova T, Olcese R, Schwingshackl A. PMID: 41252294; PMCID: PMC12716432.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Evaluation of a Rapid Immunoassay for Molecular Subphenotype Classification in Pediatric Acute Cardiorespiratory Failure. Res Sq. 2025 Sep 23. Sallee CJ, Taylor CS, Zinter MS, Markovic D, Lim MJ, Costa-Monteiro A, Cortado R, Schwingshackl A, Agus M, Matthay M, Sapru A. PMID: 41041556; PMCID: PMC12486067.
      View in: PubMed   Mentions:
    7. Pharmacological activation of BK channels protects against LPS-induced pneumonia. Sci Rep. 2025 Aug 19; 15(1):30307. Zyrianova T, Lopez B, SooHoo J, Boehmer C, Ye A, Kang H, Majumder N, Schwingshackl A. PMID: 40830381; PMCID: PMC12365261.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. Plasma Soluble Intercellular Adhesion Molecule-1 Has a Central Role in Biomarker Network Analysis and Is Associated With Poor Outcomes in Two Distinct Pediatric Cohorts of Acute Respiratory Distress Syndrome and Acute Respiratory Failure. Crit Care Med. 2025 Jul 01; 53(7):e1457-e1469. Lim MJ, Whitney JE, Sallee CJ, Markovic D, Bera A, Sinha P, Zeigler A, Chen L, Zinter MS, Ali A, Matthay MA, Schwingshackl A, Agus MSD, Sapru A, Pediatric Acute Lung Injury (PALI) and Coagulation and Fibrinolysis in Pediatric Insulin Titration T. PMID: 40459371; PMCID: PMC12323721.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. CIRCULATING HEPARAN SULFATE PROFILES IN PEDIATRIC ACUTE RESPIRATORY DISTRESS SYNDROME. Shock. 2024 10 01; 62(4):496-504. Sallee CJ, Maddux AB, Hippensteel JA, Markovic D, Oshima K, Schwingshackl A, Mourani PM, Schmidt EP, Sapru A. PMID: 39331799; PMCID: PMC12080468.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Two-pore potassium channel TREK-1 (K2P2.1) regulates NLRP3 inflammasome activity in macrophages. Am J Physiol Lung Cell Mol Physiol. 2024 Mar 01; 326(3):L367-L376. Immanuel CN, Teng B, Dong BE, Gordon EM, Luellen C, Lopez B, Harding J, Cormier SA, Fitzpatrick EA, Schwingshackl A, Waters CM. PMID: 38252657; PMCID: PMC11281793.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Endothelial Glycocalyx Degradation Patterns in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome: A Single Center Retrospective Observational Study. J Intensive Care Med. 2024 03; 39(3):277-287. Sallee CJ, Hippensteel JA, Miller KR, Oshima K, Pham AT, Richter RP, Belperio J, Sierra YL, Schwingshackl A, Mourani PM, Schmidt EP, Sapru A, Maddux AB. PMID: 37670670; PMCID: PMC10845819.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Activation of Endothelial Large Conductance Potassium Channels Protects against TNF-α-Induced Inflammation. Int J Mol Sci. 2023 Feb 17; 24(4). Zyrianova T, Zou K, Lopez B, Liao A, Gu C, Olcese R, Schwingshackl A. PMID: 36835507; PMCID: PMC9961193.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    13. Protection from acute lung injury by a peptide designed to inhibit the voltage-gated proton channel. iScience. 2023 Jan 20; 26(1):105901. Zhao R, Lopez B, Schwingshackl A, Goldstein SAN. PMID: 36660473; PMCID: PMC9843441.
      View in: PubMed   Mentions: 6  
    14. Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2023 01 01; 324(1):L64-L75. Zyrianova T, Lopez B, Zou K, Gu C, Pham D, Talapaneni S, Waters CM, Olcese R, Schwingshackl A. PMID: 36410022; PMCID: PMC9829483.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. Cell saver blood transfusions may be associated with a decrease in inflammation and improved outcome measures in pediatric cardiac surgery patients. Perfusion. 2023 05; 38(4):717-724. Martinez MJ, Schwingshackl A, Romero T, Roach GD, Belperio JA, Federman MD. PMID: 35411827.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. Beyond the Alveolar Epithelium: Plasma Soluble Receptor for Advanced Glycation End Products Is Associated With Oxygenation Impairment, Mortality, and Extrapulmonary Organ Failure in Children With Acute Respiratory Distress Syndrome. Crit Care Med. 2022 05 01; 50(5):837-847. Lim MJ, Zinter MS, Chen L, Wong KMY, Bhalla A, Gala K, Guglielmo M, Alkhouli M, Huard LL, Hanudel MR, Vangala S, Schwingshackl A, Matthay M, Sapru A. PMID: 34678846; PMCID: PMC9035468.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    17. Pediatric interfacility transport effects on mortality and length of stay. World J Pediatr. 2021 Aug; 17(4):400-408. Shinozaki RM, Schwingshackl A, Srivastava N, Grogan T, Kelly RB. PMID: 34319538; PMCID: PMC8363522.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. BK Channels Regulate LPS-induced CCL-2 Release from Human Pulmonary Endothelial Cells. Am J Respir Cell Mol Biol. 2021 02; 64(2):224-234. Zyrianova T, Lopez B, Liao A, Gu C, Wong L, Ottolia M, Olcese R, Schwingshackl A. PMID: 33217242; PMCID: PMC7874395.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    19. K2P2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury. Sci Rep. 2020 12 15; 10(1):22011. Zyrianova T, Lopez B, Olcese R, Belperio J, Waters CM, Wong L, Nguyen V, Talapaneni S, Schwingshackl A. PMID: 33319831; PMCID: PMC7738539.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    20. TREK-1 protects the heart against ischemia-reperfusion-induced injury and from adverse remodeling after myocardial infarction. Pflugers Arch. 2019 10; 471(10):1263-1272. Kamatham S, Waters CM, Schwingshackl A, Mancarella S. PMID: 31511966; PMCID: PMC8996126.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    21. Apoptosis signal-regulating kinase-1 promotes inflammasome priming in macrophages. Am J Physiol Lung Cell Mol Physiol. 2019 03 01; 316(3):L418-L427. Immanuel CN, Teng B, Dong B, Gordon EM, Kennedy JA, Luellen C, Schwingshackl A, Cormier SA, Fitzpatrick EA, Waters CM. PMID: 30628485; PMCID: PMC6459294.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1030-L1046. Schwingshackl A, Lopez B, Teng B, Luellen C, Lesage F, Belperio J, Olcese R, Waters CM. PMID: 28839101; PMCID: PMC5814704.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    23. Editorial: ARDS: Reaching for the Horizon. Front Pediatr. 2017; 5:100. McGuire JK, Schwingshackl A, Anand KJS. PMID: 28555176; PMCID: PMC5430045.
      View in: PubMed   Mentions:
    24. Editorial: Work-Life Balance: Essential or Ephemeral? Front Pediatr. 2017; 5:108. Schwingshackl A, Anand KJS. PMID: 28540286; PMCID: PMC5423898.
      View in: PubMed   Mentions:
    25. The role of stretch-activated ion channels in acute respiratory distress syndrome: finally a new target? Am J Physiol Lung Cell Mol Physiol. 2016 09 01; 311(3):L639-52. Schwingshackl A. PMID: 27521425; PMCID: PMC5142209.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    26. Prolonged Glucocorticoid Treatment in ARDS: Impact on Intensive Care Unit-Acquired Weakness. Front Pediatr. 2016; 4:69. Meduri GU, Schwingshackl A, Hermans G. PMID: 27532030; PMCID: PMC4969316.
      View in: PubMed   Mentions: 11  
    27. Rationale for Prolonged Glucocorticoid Use in Pediatric ARDS: What the Adults Can Teach Us. Front Pediatr. 2016; 4:58. Schwingshackl A, Meduri GU. PMID: 27379217; PMCID: PMC4906037.
      View in: PubMed   Mentions: 7  
    28. Plasma Biomarker Analysis in Pediatric ARDS: Generating Future Framework from a Pilot Randomized Control Trial of Methylprednisolone: A Framework for Identifying Plasma Biomarkers Related to Clinical Outcomes in Pediatric ARDS. Front Pediatr. 2016; 4:31. Kimura D, Saravia J, Rovnaghi CR, Meduri GU, Schwingshackl A, Cormier SA, Anand KJ. PMID: 27066464; PMCID: PMC4815896.
      View in: PubMed   Mentions: 10  
    29. Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 01; 310(5):L393-402. Andrews K, Ghosh MC, Schwingshackl A, Rapalo G, Luellen C, Waters CM, Fitzpatrick EA. PMID: 26719148; PMCID: PMC4773842.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    30. Regulation of inflammatory biomarkers by intravenous methylprednisolone in pediatric ARDS patients: Results from a double-blind, placebo-controlled randomized pilot trial. Cytokine. 2016 Jan; 77:63-71. Schwingshackl A, Kimura D, Rovnaghi CR, Saravia JS, Cormier SA, Teng B, West AN, Meduri UG, Anand KJ. PMID: 26545141; PMCID: PMC4666843.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    31. Corticosteroids in pediatric ARDS: all cards on the table. Intensive Care Med. 2015 Nov; 41(11):2036-7. Schwingshackl A, Meduri GU, Kimura D, Cormier SA, Anand KJ. PMID: 26359160; PMCID: PMC4584398.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. TREK-1 Regulates Cytokine Secretion from Cultured Human Alveolar Epithelial Cells Independently of Cytoskeletal Rearrangements. PLoS One. 2015; 10(5):e0126781. Schwingshackl A, Roan E, Teng B, Waters CM. PMID: 26001192; PMCID: PMC4441361.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    33. Inverse Relationship between Cardio-Ankle Vascular Index and Body Mass Index in Healthy Children. J Pediatr. 2015 Aug; 167(2):361-365.e1. Philip R, Alpert BS, Schwingshackl A, Huang X, Blakely D, Rovnaghi CR, Tran QT, Velasquez A, Arevalo A, Anand KJ. PMID: 26003881.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    34. Double-blind, placebo-controlled pilot randomized trial of methylprednisolone infusion in pediatric acute respiratory distress syndrome. Pediatr Crit Care Med. 2015 Mar; 16(3):e74-81. Drago BB, Kimura D, Rovnaghi CR, Schwingshackl A, Rayburn M, Meduri GU, Anand KJ. PMID: 25634565.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    35. Pulmonary epithelial barrier function: some new players and mechanisms. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15; 308(8):L731-45. Brune K, Frank J, Schwingshackl A, Finigan J, Sidhaye VK. PMID: 25637609; PMCID: PMC4747906.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    36. Deficiency of the two-pore-domain potassium channel TREK-1 promotes hyperoxia-induced lung injury. Crit Care Med. 2014 Nov; 42(11):e692-701. Schwingshackl A, Teng B, Makena P, Ghosh M, Sinclair SE, Luellen C, Balasz L, Rovnaghi C, Bryan RM, Lloyd EE, Fitzpatrick E, Saravia JS, Cormier SA, Waters CM. PMID: 25126877; PMCID: PMC4199872.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    37. The fallacy of chasing after work-life balance. Front Pediatr. 2014; 2:26. Schwingshackl A. PMID: 24745004; PMCID: PMC3978284.
      View in: PubMed   Mentions: 4  
    38. The 2-pore domain potassium channel TREK-1 regulates stretch-induced detachment of alveolar epithelial cells. PLoS One. 2014; 9(2):e89429. Roan E, Waters CM, Teng B, Ghosh M, Schwingshackl A. PMID: 24586773; PMCID: PMC3929719.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    39. Regulation of Monocyte Chemotactic Protein-1 secretion by the Two-Pore-Domain Potassium (K2P) channel TREK-1 in human alveolar epithelial cells. Am J Transl Res. 2013; 5(5):530-42. Schwingshackl A, Teng B, Ghosh M, Waters CM. PMID: 23977412; PMCID: PMC3745440.
      View in: PubMed   Mentions: 21  
    40. Insulin-like growth factor-I stimulates differentiation of ATII cells to ATI-like cells through activation of Wnt5a. Am J Physiol Lung Cell Mol Physiol. 2013 Aug 01; 305(3):L222-8. Ghosh MC, Gorantla V, Makena PS, Luellen C, Sinclair SE, Schwingshackl A, Waters CM. PMID: 23709620; PMCID: PMC3743013.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    41. Regulation of interleukin-6 secretion by the two-pore-domain potassium channel Trek-1 in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15; 304(4):L276-86. Schwingshackl A, Teng B, Ghosh M, Lim KG, Tigyi G, Narayanan D, Jaggar JH, Waters CM. PMID: 23275623; PMCID: PMC3567358.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    42. Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 01; 302(1):L93-L102. Schwingshackl A, Teng B, Ghosh M, West AN, Makena P, Gorantla V, Sinclair SE, Waters CM. PMID: 21949155; PMCID: PMC3349376.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    43. Expression and activity of matrix metallo proteinases 2 and 9 and their inhibitors in rat lungs during the perinatal period and in diaphragmatic hernia. Exp Lung Res. 2003 Jun; 29(4):261-76. Lemke RP, Zhang W, Balcerazak D, Kobayashi K, Schwingshackl A, Cheung PY, Dixon WT, Baracos VE, Greer JJ. PMID: 12746050.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    44. Nitric oxide activates ATP-dependent K+ channels in human eosinophils. J Leukoc Biol. 2002 May; 71(5):807-12. Schwingshackl A, Moqbel R, Duszyk M. PMID: 11994505.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    45. Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells. J Allergy Clin Immunol. 2000 Sep; 106(3):537-45. Vliagoftis H, Schwingshackl A, Milne CD, Duszyk M, Hollenberg MD, Wallace JL, Befus AD, Moqbel R. PMID: 10984375.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    46. Involvement of ion channels in human eosinophil respiratory burst. J Allergy Clin Immunol. 2000 Aug; 106(2):272-9. Schwingshackl A, Moqbel R, Duszyk M. PMID: 10932070.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    47. Human eosinophils release matrix metalloproteinase-9 on stimulation with TNF-alpha. J Allergy Clin Immunol. 1999 Nov; 104(5):983-9. Schwingshackl A, Duszyk M, Brown N, Moqbel R. PMID: 10550743.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
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