Jerzy W Kupiec-Weglinski

Title(s)Professor, Surgery
SchoolMedicine
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    Other Positions
    Title(s)Professor, Pathology and Laboratory Medicine


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    THE RELAXIN RECEPTOR GR/RXFP1 SIGNALING IN LIVER TRANSPLANT ISCHEMIA-REPERFUSION INJURY AND THE INFLAMMATION RESOLUTION
    NIH R01AI155856Sep 22, 2020 - Aug 31, 2025
    Role: Principal Investigator
    Immune Regulation by Stem Cells: Role of Beta-Catenin in Liver Inflammatory Injury
    NIH R21AI115133Aug 17, 2017 - Jul 31, 2019
    Role: Co-Principal Investigator
    Innate-Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury
    NIH P01AI120944Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    TIM-3 Negative Costimulation Signaling at the Innate-Adaptive Immune interface in Liver Transplant Ischemia-Reperfusion Injury
    NIH R01DK107533Jan 1, 2016 - Dec 31, 2021
    Role: Principal Investigator
    Tim Costimulation in Liver Transplant Ischemia Injury
    NIH R01DK102110Apr 1, 2015 - Mar 31, 2020
    Role: Principal Investigator
    Beta-Catenin Signaling in Liver Ischemia and Reperfusion Injury
    NIH R21AI112722Jul 15, 2014 - Jun 30, 2016
    Role: Co-Principal Investigator
    COSTIMULATORY PATHWAYS IN SENSITIZED GRAFT RECIPIENTS
    NIH R56AI023847Sep 12, 2009 - Aug 31, 2011
    Role: Principal Investigator
    HuR/HIF ? SIRT1 Signaling Axis in Liver Transplant Rejuvenation
    NIH R01DK062357Jul 1, 2002 - Mar 31, 2026
    Role: Principal Investigator
    CD4+ T REG CELLS IN MAINTENANCE OF TRANSPLANT TOLERANCE
    NIH R01AI042223Jul 1, 1998 - Jun 30, 2010
    Role: Principal Investigator
    COSTIMULATORY PATHWAYS IN SENSITIZED GRAFT RECIPIENTS
    NIH R01AI023847Apr 1, 1988 - Mar 31, 2007
    Role: Principal Investigator
    COSTIMULATORY PATHWAYS SENSITIZED GRAFT RECIPIENTS
    NIH R21AI023847Apr 1, 1988 - May 31, 2002
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The human microbiome in transplantation: the past, present, and future. Curr Opin Organ Transplant. 2021 Sep 20. Dery KJ, Kupiec-Weglinski JW, Dong TS. PMID: 34545840.
      View in: PubMed   Mentions:    Fields:    
    2. Reply to: "The Impact of Donor Liver Fibrosis on Early Allograft Dysfunction and Ischemia-Reperfusion Injury." Hepatology. 2021 Sep 03. Hirao H, Ito T, Kupiec-Weglinski JW, Kaldas FM. PMID: 34478574.
      View in: PubMed   Mentions:    Fields:    
    3. Ischemia-reperfusion Injury in Allogeneic Liver Transplantation: A Role of CD4 T Cells in Early Allograft Injury. Transplantation. 2021 Sep 01; 105(9):1989-1997. Kageyama S, Kadono K, Hirao H, Nakamura K, Ito T, Gjertson DW, Sosa RA, Reed EF, Kaldas FM, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. PMID: 33065722.
      View in: PubMed   Mentions: 1     Fields:    
    4. T-Cell Immunoglobulin and Mucin Domain-Containing Protein-4 Is Critical for Kupffer Cell Homeostatic Function in the Activation and Resolution of Liver Ischemia Reperfusion Injury. Hepatology. 2021 Oct; 74(4):2118-2132. Ni M, Zhang J, Sosa R, Zhang H, Wang H, Jin D, Crowley K, Naini B, Reed FE, Busuttil RW, Kupiec-Weglinski JW, Wang X, Zhai Y. PMID: 33999437.
      View in: PubMed   Mentions:    Fields:    
    5. Donor Hepatic Occult Collagen Deposition Predisposes to Peritransplant Stress and Impacts Human Liver Transplantation. Hepatology. 2021 Jun 25. Hirao H, Ito T, Kadono K, Kojima H, Naini BV, Nakamura K, Kageyama S, Busuttil RW, Kupiec-Weglinski JW, Kaldas FM. PMID: 34170562.
      View in: PubMed   Mentions:    Fields:    
    6. Functional crosstalk between myeloid Foxo1-β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response. Cell Death Differ. 2021 May; 28(5):1705-1719. Li C, Sheng M, Lin Y, Xu D, Tian Y, Zhan Y, Jiang L, Coito AJ, Busuttil RW, Farmer DG, Kupiec-Weglinski JW, Ke B. PMID: 33288903.
      View in: PubMed   Mentions: 1     Fields:    
    7. Disulfide High-Mobility Group Box 1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation. Hepatology. 2021 03; 73(3):1158-1175. Sosa RA, Terry AQ, Kaldas FM, Jin YP, Rossetti M, Ito T, Li F, Ahn RS, Naini BV, Groysberg VM, Zheng Y, Aziz A, Nevarez-Mejia J, Zarrinpar A, Busuttil RW, Gjertson DW, Kupiec-Weglinski JW, Reed EF. PMID: 32426849.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. Ischemia-reperfusion injury and its relationship with early allograft dysfunction in liver transplant patients. Am J Transplant. 2021 02; 21(2):614-625. Ito T, Naini BV, Markovic D, Aziz A, Younan S, Lu M, Hirao H, Kadono K, Kojima H, DiNorcia J, Agopian VG, Yersiz H, Farmer DG, Busuttil RW, Kupiec-Weglinski JW, Kaldas FM. PMID: 32713098.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    9. Isoform- and Cell Type-Specific Roles of Glycogen Synthase Kinase 3 N-Terminal Serine Phosphorylation in Liver Ischemia Reperfusion Injury. J Immunol. 2020 08 15; 205(4):1147-1156. Ni M, Zhou H, Zhang J, Jin D, Lu T, Busuttil RW, Kupiec-Weglinski JW, Wang X, Zhai Y. PMID: 32680958.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Human Antigen R (HuR): A Regulator of Heme Oxygenase-1 Cytoprotection in Mouse and Human Liver Transplant Injury. Hepatology. 2020 09; 72(3):1056-1072. Dery KJ, Nakamura K, Kadono K, Hirao H, Kageyama S, Ito T, Kojima H, Kaldas FM, Busuttil RW, Kupiec-Weglinski JW. PMID: 31879990.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Pattern Recognition Receptor-reactivity Screening of Liver Transplant Patients: Potential for Personalized and Precise Organ Matching to Reduce Risks of Ischemia-reperfusion Injury. Ann Surg. 2020 05; 271(5):922-931. Sosa RA, Rossetti M, Naini BV, Groysberg VM, Kaldas FM, Busuttil RW, Chang YL, Gjertson DW, Kupiec-Weglinski JW, Reed EF. PMID: 30480558.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    12. Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injury. J Clin Invest. 2020 05 01; 130(5):2689-2704. Nakamura K, Kageyama S, Kaldas FM, Hirao H, Ito T, Kadono K, Dery KJ, Kojima H, Gjertson DW, Sosa RA, Kujawski M, Busuttil RW, Reed EF, Kupiec-Weglinski JW. PMID: 32027621.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury. Theranostics. 2020; 10(10):4453-4465. Xue Z, Zhang Y, Liu Y, Zhang C, Shen XD, Gao F, Busuttil RW, Zheng S, Kupiec-Weglinski JW, Ji H. PMID: 32292507.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    14. Heme Oxygenase-1 in liver transplant ischemia-reperfusion injury: From bench-to-bedside. Free Radic Biol Med. 2020 09; 157:75-82. Hirao H, Dery KJ, Kageyama S, Nakamura K, Kupiec-Weglinski JW. PMID: 32084514.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    15. Farnesoid X Receptor Activation Protects Liver From Ischemia/Reperfusion Injury by Up-Regulating Small Heterodimer Partner in Kupffer Cells. Hepatol Commun. 2020 Apr; 4(4):540-554. Jin D, Lu T, Ni M, Wang H, Zhang J, Zhong C, Shen C, Hao J, Busuttil RW, Kupiec-Weglinski JW, Zhang J, Xu N, Zhai Y. PMID: 32258949.
      View in: PubMed   Mentions: 4  
    16. Innate immunity in ischemia-reperfusion injury and graft rejection. Curr Opin Organ Transplant. 2019 12; 24(6):687-693. Nakamura K, Kageyama S, Kupiec-Weglinski JW. PMID: 31592839.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Impact of Rifaximin Therapy on Ischemia/Reperfusion Injury in Liver Transplantation: A Propensity Score-Matched Analysis. Liver Transpl. 2019 12; 25(12):1778-1789. Ito T, Nakamura K, Kageyama S, Korayem IM, Hirao H, Kadono K, Aziz J, Younan S, DiNorcia J, Agopian VG, Yersiz H, Farmer DG, Busuttil RW, Kupiec-Weglinski JW, Kaldas FM. PMID: 31509643.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury. Cell Mol Immunol. 2020 12; 17(12):1245-1256. Jin Y, Li C, Xu D, Zhu J, Wei S, Zhong A, Sheng M, Duarte S, Coito AJ, Busuttil RW, Xia Q, Kupiec-Weglinski JW, Ke B. PMID: 31673056.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    19. Vertical Sleeve Gastrectomy Attenuates the Progression of Non-Alcoholic Steatohepatitis in Mice on a High-Fat High-Cholesterol Diet. Obes Surg. 2019 08; 29(8):2420-2429. Whang E, Liu Y, Kageyama S, Woo SL, Yang J, Lee R, Li Z, Ji H, Chen Y, Kupiec-Weglinski JW. PMID: 30982168.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    20. Pituitary Adenylate Cyclase-activating Polypeptides Prevent Hepatocyte Damage by Promoting Yes-associated Protein in Liver Ischemia-Reperfusion Injury. Transplantation. 2019 08; 103(8):1639-1648. Liu Y, Lu T, Zhang C, Xue Z, Xu J, Busuttil RW, Xia Q, Xu N, Kupiec-Weglinski JW, Ji H. PMID: 31348437.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. Antibiotic pretreatment alleviates liver transplant damage in mice and humans. J Clin Invest. 2019 07 22; 129(8):3420-3434. Nakamura K, Kageyama S, Ito T, Hirao H, Kadono K, Aziz A, Dery KJ, Everly MJ, Taura K, Uemoto S, Farmer DG, Kaldas FM, Busuttil RW, Kupiec-Weglinski JW. PMID: 31329160.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    22. Heme Oxygenase-1 dictates innate - adaptive immune phenotype in human liver transplantation. Arch Biochem Biophys. 2019 08 15; 671:162-166. Kadono K, Dery KJ, Hirao H, Ito T, Kageyama S, Nakamura K, Oncel D, Aziz A, Kaldas FM, Busuttil RW, Kupiec-Weglinski JW. PMID: 31299184.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Hippo Signaling Controls NLR Family Pyrin Domain Containing 3 Activation and Governs Immunoregulation of Mesenchymal Stem Cells in Mouse Liver Injury. Hepatology. 2019 11; 70(5):1714-1731. Li C, Jin Y, Wei S, Sun Y, Jiang L, Zhu Q, Farmer DG, Busuttil RW, Kupiec-Weglinski JW, Ke B. PMID: 31063235.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    24. Activation of YAP attenuates hepatic damage and fibrosis in liver ischemia-reperfusion injury. J Hepatol. 2019 10; 71(4):719-730. Liu Y, Lu T, Zhang C, Xu J, Xue Z, Busuttil RW, Xu N, Xia Q, Kupiec-Weglinski JW, Ji H. PMID: 31201834.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    25. Inhibition of Cyclin-dependent Kinase 2 Signaling Prevents Liver Ischemia and Reperfusion Injury. Transplantation. 2019 04; 103(4):724-732. Xu J, Xue Z, Zhang C, Liu Y, Busuttil RW, Zhang J, Kupiec-Weglinski JW, Ji H. PMID: 30801519.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. The Evolving Role of Neutrophils in Liver Transplant Ischemia-Reperfusion Injury. Curr Transplant Rep. 2019; 6(1):78-89. Nakamura K, Kageyama S, Kupiec-Weglinski JW. PMID: 31602356.
      View in: PubMed   Mentions: 7  
    27. Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury. JCI Insight. 2018 10 04; 3(19). Zhang M, Nakamura K, Kageyama S, Lawal AO, Gong KW, Bhetraratana M, Fujii T, Sulaiman D, Hirao H, Bolisetty S, Kupiec-Weglinski JW, Araujo JA. PMID: 30282830.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    28. Recipient HO-1 inducibility is essential for posttransplant hepatic HO-1 expression and graft protection: From bench-to-bedside. Am J Transplant. 2019 02; 19(2):356-367. Kageyama S, Hirao H, Nakamura K, Ke B, Zhang M, Ito T, Aziz A, Oncel D, Kaldas FM, Busuttil RW, Sosa RA, Reed EF, Araujo JA, Kupiec-Weglinski JW. PMID: 30059195.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Reply to: "Protective effects of heme oxygenase 1 during ischemia-reperfusion injury: Hepatocytes or non parenchymal cells?" J Hepatol. 2018 09; 69(3):753-755. Nakamura K, Zhang M, Kageyama S, Ke B, Araujo JA, Kupiec-Weglinski JW. PMID: 29870762.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. Lipid Metabolites: The Alarm Signal to Trigger Liver Ischemia-reperfusion Injury. Transplantation. 2018 06; 102(6):887-889. Ke B, Kupiec-Weglinski JW. PMID: 29782474.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    31. Recombinant relaxin protects liver transplants from ischemia damage by hepatocyte glucocorticoid receptor: From bench-to-bedside. Hepatology. 2018 07; 68(1):258-273. Kageyama S, Nakamura K, Fujii T, Ke B, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. PMID: 29350771.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    32. Serelaxin induces Notch1 signaling and alleviates hepatocellular damage in orthotopic liver transplantation. Am J Transplant. 2018 07; 18(7):1755-1763. Kageyama S, Nakamura K, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 29464890.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    33. Glycogen synthase kinase 3β promotes liver innate immune activation by restraining AMP-activated protein kinase activation. J Hepatol. 2018 07; 69(1):99-109. Zhou H, Wang H, Ni M, Yue S, Xia Y, Busuttil RW, Kupiec-Weglinski JW, Lu L, Wang X, Zhai Y. PMID: 29452207.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    34. Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers. Hepatology. 2018 03; 67(3):1041-1055. Lu L, Yue S, Jiang L, Li C, Zhu Q, Ke M, Lu H, Wang X, Busuttil RW, Ying QL, Kupiec-Weglinski JW, Ke B. PMID: 29024000.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    35. Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation: From mouse to human. Am J Transplant. 2018 05; 18(5):1110-1121. Nakamura K, Kageyama S, Yue S, Huang J, Fujii T, Ke B, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. PMID: 29136322.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    36. Outside-in HLA class I signaling regulates ICAM-1 clustering and endothelial cell-monocyte interactions via mTOR in transplant antibody-mediated rejection. Am J Transplant. 2018 05; 18(5):1096-1109. Salehi S, Sosa RA, Jin YP, Kageyama S, Fishbein MC, Rozengurt E, Kupiec-Weglinski JW, Reed EF. PMID: 29045076.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    37. Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/Reperfusion: From mouse to human. Liver Transpl. 2017 10; 23(10):1282-1293. Nakamura K, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. PMID: 28719070.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    38. Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury. J Hepatol. 2017 12; 67(6):1232-1242. Nakamura K, Zhang M, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. PMID: 28842295.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    39. Phosphatase and tensin homolog-β-catenin signaling modulates regulatory T cells and inflammatory responses in mouse liver ischemia/reperfusion injury. Liver Transpl. 2017 06; 23(6):813-825. Zhu Q, Li C, Wang K, Yue S, Jiang L, Ke M, Busuttil RW, Kupiec-Weglinski JW, Zhang F, Lu L, Ke B. PMID: 28152578.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    40. Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury. J Immunol. 2017 05 01; 198(9):3588-3595. Yue S, Zhou H, Wang X, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. PMID: 28289160.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    41. Bruton Tyrosine Kinase Inhibition Attenuates Liver Damage in a Mouse Warm Ischemia and Reperfusion Model. Transplantation. 2017 02; 101(2):322-331. Palumbo T, Nakamura K, Lassman C, Kidani Y, Bensinger SJ, Busuttil R, Kupiec-Weglinski J, Zarrinpar A. PMID: 27820779.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    42. Early cytokine signatures of ischemia/reperfusion injury in human orthotopic liver transplantation. JCI Insight. 2016 12 08; 1(20):e89679. Sosa RA, Zarrinpar A, Rossetti M, Lassman CR, Naini BV, Datta N, Rao P, Harre N, Zheng Y, Spreafico R, Hoffmann A, Busuttil RW, Gjertson DW, Zhai Y, Kupiec-Weglinski JW, Reed EF. PMID: 27942590.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    43. Innate Immune Regulations and Liver Ischemia-Reperfusion Injury. Transplantation. 2016 Dec; 100(12):2601-2610. Lu L, Zhou H, Ni M, Wang X, Busuttil R, Kupiec-Weglinski J, Zhai Y. PMID: 27861288.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    44. The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury. Hepatology. 2016 11; 64(5):1683-1698. Yue S, Zhu J, Zhang M, Li C, Zhou X, Zhou M, Ke M, Busuttil RW, Ying QL, Kupiec-Weglinski JW, Xia Q, Ke B. PMID: 27474884.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    45. The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury. Transplantation. 2016 Feb; 100(2):365-72. Zhou H, Zhu J, Yue S, Lu L, Busuttil RW, Kupiec-Weglinski JW, Wang X, Zhai Y. PMID: 26683513.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    46. Negative CD4 + TIM-3 signaling confers resistance against cold preservation damage in mouse liver transplantation. Am J Transplant. 2015 Apr; 15(4):954-964. Liu Y, Ji H, Zhang Y, Shen XD, Gao F, Nguyen TT, Shang X, Lee N, Busuttil RW, Kupiec-Weglinski JW. PMID: 25676534.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    47. Rapamycin protection of livers from ischemia and reperfusion injury is dependent on both autophagy induction and mammalian target of rapamycin complex 2-Akt activation. Transplantation. 2015 Jan; 99(1):48-55. Zhu J, Lu T, Yue S, Shen X, Gao F, Busuttil RW, Kupiec-Weglinski JW, Xia Q, Zhai Y. PMID: 25340604.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    48. Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury. J Hepatol. 2015 Mar; 62(3):563-72. Liu Y, Ji H, Zhang Y, Shen X, Gao F, He X, Li GA, Busuttil RW, Kuchroo VK, Kupiec-Weglinski JW. PMID: 25450716.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    49. T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury. Hepatology. 2014 Dec; 60(6):2052-2064. Ji H, Liu Y, Zhang Y, Shen XD, Gao F, Busuttil RW, Kuchroo VK, Kupiec-Weglinski JW. PMID: 25066922.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    50. Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network. Transplantation. 2014 Oct 15; 98(7):721-8. Huang J, Yue S, Ke B, Zhu J, Shen XD, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. PMID: 25171655.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    51. Adoptive transfer of heme oxygenase-1 (HO-1)-modified macrophages rescues the nuclear factor erythroid 2-related factor (Nrf2) antiinflammatory phenotype in liver ischemia/reperfusion injury. Mol Med. 2014 Oct 14; 20:448-55. Huang J, Shen XD, Yue S, Zhu J, Gao F, Zhai Y, Busuttil RW, Ke B, Kupiec-Weglinski JW. PMID: 25014792.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    52. Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation. J Immunol. 2014 Jun 01; 192(11):5343-5353. Yue S, Rao J, Zhu J, Busuttil RW, Kupiec-Weglinski JW, Lu L, Wang X, Zhai Y. PMID: 24771857.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    53. The innate immune system and transplantation. Cold Spring Harb Perspect Med. 2013 Oct 01; 3(10):a015479. Farrar CA, Kupiec-Weglinski JW, Sacks SH. PMID: 24086066.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    54. Vasoactive intestinal peptide attenuates liver ischemia/reperfusion injury in mice via the cyclic adenosine monophosphate-protein kinase a pathway. Liver Transpl. 2013 Sep; 19(9):945-56. Ji H, Zhang Y, Liu Y, Shen XD, Gao F, Nguyen TT, Busuttil RW, Waschek JA, Kupiec-Weglinski JW. PMID: 23744729.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    55. KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. J Hepatol. 2013 Dec; 59(6):1200-7. Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. PMID: 23867319.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    56. ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatology. 2013 Jul; 58(1):351-62. Kamo N, Ke B, Ghaffari AA, Shen XD, Busuttil RW, Cheng G, Kupiec-Weglinski JW. PMID: 23408710.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    57. β-catenin regulates innate and adaptive immunity in mouse liver ischemia-reperfusion injury. Hepatology. 2013 Mar; 57(3):1203-14. Ke B, Shen XD, Kamo N, Ji H, Yue S, Gao F, Busuttil RW, Kupiec-Weglinski JW. PMID: 23081841.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    58. Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation by the cAMP-PKA pathway. Hepatology. 2013 Mar; 57(3):1225-37. Ji H, Zhang Y, Shen XD, Gao F, Huang CY, Abad C, Busuttil RW, Waschek JA, Kupiec-Weglinski JW. PMID: 22532103.
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    59. Ischemia/Reperfusion injury, its mechanisms, and prevention. J Transplant. 2012; 2012:610370. Kosieradzki M, Pratschke J, Kupiec-Weglinski J, Rowinski W. PMID: 23320144.
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    60. Ischaemia-reperfusion injury in liver transplantation--from bench to bedside. Nat Rev Gastroenterol Hepatol. 2013 Feb; 10(2):79-89. Zhai Y, Petrowsky H, Hong JC, Busuttil RW, Kupiec-Weglinski JW. PMID: 23229329.
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    61. PTEN-mediated Akt/β-catenin/Foxo1 signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury. Hepatology. 2013 Jan; 57(1):289-98. Kamo N, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 22807038.
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    62. Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury. Transplantation. 2012 Aug 15; 94(3):211-7. Liu J, Ren F, Cheng Q, Bai L, Shen X, Gao F, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. PMID: 22790388.
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    63. Activation of cyclic adenosine monophosphate-dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice. Liver Transpl. 2012 Jun; 18(6):659-70. Ji H, Shen XD, Zhang Y, Gao F, Huang CY, Chang WW, Lee C, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 22290937.
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    64. Treatment with antithymocyte globulin ameliorates intestinal ischemia and reperfusion injury in mice. Surgery. 2012 Nov; 152(5):843-50. Watson MJ, Ke B, Shen XD, Gao F, Busuttil RW, Kupiec-Weglinski JW, Farmer DG. PMID: 22575884.
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    65. Interleukin-22: implications for liver ischemia-reperfusion injury. Transplantation. 2012 Mar 15; 93(5):485-92. Chestovich PJ, Uchida Y, Chang W, Ajalat M, Lassman C, Sabat R, Busuttil RW, Kupiec-Weglinski JW. PMID: 22262131.
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    66. Regulated hepatic reperfusion mitigates ischemia-reperfusion injury and improves survival after prolonged liver warm ischemia: a pilot study on a novel concept of organ resuscitation in a large animal model. J Am Coll Surg. 2012 Apr; 214(4):505-15; discussion 515-6. Hong JC, Koroleff D, Xia V, Chang CM, Duarte SM, Xu J, Lassman C, Kupiec-Weglinski J, Coito AJ, Busuttil RW. PMID: 22321520.
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    67. Type I interferon pathway mediates renal ischemia/reperfusion injury. Transplantation. 2011 Jul 27; 92(2):131-8. Freitas MC, Uchida Y, Lassman C, Danovitch GM, Busuttil RW, Kupiec-Weglinski JW. PMID: 21577179.
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    68. HO-1-STAT3 axis in mouse liver ischemia/reperfusion injury: regulation of TLR4 innate responses through PI3K/PTEN signaling. J Hepatol. 2012 Feb; 56(2):359-66. Ke B, Shen XD, Ji H, Kamo N, Gao F, Freitas MC, Busuttil RW, Kupiec-Weglinski JW. PMID: 21756853.
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    69. Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism. Hepatology. 2011 Aug; 54(2):687-96. Ren F, Duan Z, Cheng Q, Shen X, Gao F, Bai L, Liu J, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. PMID: 21567437.
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    70. Alloreactive CD8 T-cell primed/memory responses and accelerated graft rejection in B-cell-deficient sensitized mice. Transplantation. 2011 May 27; 91(10):1075-81. Ji H, Shen XD, Gao F, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. PMID: 21427633.
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    71. Interleukin-13 protects mouse intestine from ischemia and reperfusion injury through regulation of innate and adaptive immunity. Transplantation. 2011 Apr 15; 91(7):737-43. Farmer DG, Ke B, Shen XD, Kaldas FM, Gao F, Watson MJ, Busuttil RW, Kupiec-Weglinski JW. PMID: 21311412.
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    72. Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury. Liver Transpl. 2011 Feb; 17(2):201-10. Shen XD, Ke B, Uchida Y, Ji H, Gao F, Zhai Y, Busuttil RW, Kupiec-Weglinski JW. PMID: 21280193.
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    73. Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury. Hepatology. 2010 Oct; 52(4):1380-9. Ji H, Shen X, Gao F, Ke B, Freitas MC, Uchida Y, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. PMID: 20815020.
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    74. T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner. Gastroenterology. 2010 Dec; 139(6):2195-206. Uchida Y, Ke B, Freitas MC, Yagita H, Akiba H, Busuttil RW, Najafian N, Kupiec-Weglinski JW. PMID: 20637206.
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    75. The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. Transplantation. 2010 May 15; 89(9):1050-6. Uchida Y, Freitas MC, Zhao D, Busuttil RW, Kupiec-Weglinski JW. PMID: 20160675.
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    76. Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion. Liver Transpl. 2010 May; 16(5):600-10. Freitas MC, Uchida Y, Zhao D, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 20440769.
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    77. The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse. Hepatology. 2010 Apr; 51(4):1363-72. Uchida Y, Ke B, Freitas MC, Ji H, Zhao D, Benjamin ER, Najafian N, Yagita H, Akiba H, Busuttil RW, Kupiec-Weglinski JW. PMID: 20091883.
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    78. Adoptive transfer of ex vivo HO-1 modified bone marrow-derived macrophages prevents liver ischemia and reperfusion injury. Mol Ther. 2010 May; 18(5):1019-25. Ke B, Shen XD, Gao F, Ji H, Qiao B, Zhai Y, Farmer DG, Busuttil RW, Kupiec-Weglinski JW. PMID: 20029397.
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    79. CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury. Hepatology. 2009 Nov; 50(5):1537-46. Shen X, Wang Y, Gao F, Ren F, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. PMID: 19670423.
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    80. Small interfering RNA targeting heme oxygenase-1 (HO-1) reinforces liver apoptosis induced by ischemia-reperfusion injury in mice: HO-1 is necessary for cytoprotection. Hum Gene Ther. 2009 Oct; 20(10):1133-42. Ke B, Shen XD, Gao F, Qiao B, Ji H, Busuttil RW, Volk HD, Kupiec-Weglinski JW. PMID: 19534599.
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    81. The inhibition of neutrophil elastase ameliorates mouse liver damage due to ischemia and reperfusion. Liver Transpl. 2009 Aug; 15(8):939-47. Uchida Y, Freitas MC, Zhao D, Busuttil RW, Kupiec-Weglinski JW. PMID: 19642132.
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    82. Tezosentan, a novel endothelin receptor antagonist, markedly reduces rat hepatic ischemia and reperfusion injury in three different models. Liver Transpl. 2008 Dec; 14(12):1737-44. Farmer DG, Kaldas F, Anselmo D, Katori M, Shen XD, Lassman C, Kaldas M, Clozel M, Busuttil RW, Kupiec-Weglinski J. PMID: 19025917.
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    83. The membrane attack complex (C5b-9) in liver cold ischemia and reperfusion injury. Liver Transpl. 2008 Aug; 14(8):1133-41. Fondevila C, Shen XD, Tsuchihashi S, Uchida Y, Freitas MC, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 18668646.
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    84. Critical role of CD4 help in CD154 blockade-resistant memory CD8 T cell activation and allograft rejection in sensitized recipients. J Immunol. 2008 Jul 15; 181(2):1096-102. Wu Z, Wang Y, Gao F, Shen X, Zhai Y, Kupiec-Weglinski JW. PMID: 18606661.
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    85. Differential impact of CD154 costimulation blockade on alloreactive effector and regulatory T cells in murine renal transplant recipients. Transplantation. 2008 May 15; 85(9):1332-8. Meng L, Wu Z, Wang Y, Lassman C, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. PMID: 18475192.
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    86. Molecular mediators of liver ischemia and reperfusion injury: a brief review. Mol Med. 2008 May-Jun; 14(5-6):337-45. Vardanian AJ, Busuttil RW, Kupiec-Weglinski JW. PMID: 18292799.
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    87. Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury. Transplantation. 2008 Apr 15; 85(7):1016-22. Zhai Y, Qiao B, Shen XD, Gao F, Busuttil RW, Cheng G, Platt JL, Volk HD, Kupiec-Weglinski JW. PMID: 18408583.
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    88. Evaluation of gene promoters for liver expression by hydrodynamic gene transfer. J Surg Res. 2008 Jul; 148(1):60-6. Nguyen AT, Dow AC, Kupiec-Weglinski J, Busuttil RW, Lipshutz GS. PMID: 18570932.
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    89. Anti-MHC class I antibody activation of proliferation and survival signaling in murine cardiac allografts. J Immunol. 2008 Feb 15; 180(4):2214-24. Jindra PT, Hsueh A, Hong L, Gjertson D, Shen XD, Gao F, Dang J, Mischel PS, Baldwin WM, Fishbein MC, Kupiec-Weglinski JW, Reed EF. PMID: 18250428.
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    90. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Hepatology. 2008 Jan; 47(1):207-14. Zhai Y, Shen XD, Gao F, Zhao A, Freitas MC, Lassman C, Luster AD, Busuttil RW, Kupiec-Weglinski JW. PMID: 18041715.
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    91. Type I, but not type II, interferon is critical in liver injury induced after ischemia and reperfusion. Hepatology. 2008 Jan; 47(1):199-206. Zhai Y, Qiao B, Gao F, Shen X, Vardanian A, Busuttil RW, Kupiec-Weglinski JW. PMID: 17935177.
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    92. Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strains. Cell Immunol. 2007 Jul; 248(1):48-58. Semiletova NV, Shen XD, Feldman DM, Gao F, Mhoyan A, Liu D, Busuttil RW, Kupiec-Weglinski JW, Ghobrial RM. PMID: 17936255.
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    93. Defective alloreactive CD8 T cell function and memory response in allograft recipients in the absence of CD4 help. J Immunol. 2007 Oct 01; 179(7):4529-34. Zhai Y, Wang Y, Wu Z, Kupiec-Weglinski JW. PMID: 17878349.
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    94. Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model. Liver Transpl. 2007 Oct; 13(10):1435-43. Shen XD, Ke B, Zhai Y, Gao F, Tsuchihashi S, Lassman CR, Busuttil RW, Kupiec-Weglinski JW. PMID: 17902130.
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    95. Heme oxygenase-1 mediated cytoprotection against liver ischemia and reperfusion injury: inhibition of type-1 interferon signaling. Transplantation. 2007 Jun 27; 83(12):1628-34. Tsuchihashi S, Zhai Y, Bo Q, Busuttil RW, Kupiec-Weglinski JW. PMID: 17589347.
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    96. Viral interleukin-10 gene transfer prevents liver ischemia-reperfusion injury: Toll-like receptor-4 and heme oxygenase-1 signaling in innate and adaptive immunity. Hum Gene Ther. 2007 Apr; 18(4):355-66. Ke B, Shen XD, Tsuchihashi S, Gao F, Araujo JA, Busuttil RW, Ritter T, Kupiec-Weglinski JW. PMID: 17439357.
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    97. A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia. Liver Transpl. 2007 Mar; 13(3):361-6. Hoglen NC, Anselmo DM, Katori M, Kaldas M, Shen XD, Valentino KL, Lassman C, Busuttil RW, Kupiec-Weglinski JW, Farmer DG. PMID: 17318854.
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    98. Basal rather than induced heme oxygenase-1 levels are crucial in the antioxidant cytoprotection. J Immunol. 2006 Oct 01; 177(7):4749-57. Tsuchihashi S, Livhits M, Zhai Y, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. PMID: 16982915.
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    99. CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury. J Immunol. 2006 May 15; 176(10):6313-22. Zhai Y, Shen XD, Hancock WW, Gao F, Qiao B, Lassman C, Belperio JA, Strieter RM, Busuttil RW, Kupiec-Weglinski JW. PMID: 16670343.
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    100. CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent. J Immunol. 2006 May 15; 176(10):5988-94. Zhai Y, Meng L, Gao F, Wang Y, Busuttil RW, Kupiec-Weglinski JW. PMID: 16670307.
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    101. Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2809-14. Bailly-Maitre B, Fondevila C, Kaldas F, Droin N, Luciano F, Ricci JE, Croxton R, Krajewska M, Zapata JM, Kupiec-Weglinski JW, Farmer D, Reed JC. PMID: 16478805.
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    102. Vascular endothelial growth factor antagonist modulates leukocyte trafficking and protects mouse livers against ischemia/reperfusion injury. Am J Pathol. 2006 Feb; 168(2):695-705. Tsuchihashi S, Ke B, Kaldas F, Flynn E, Busuttil RW, Briscoe DM, Kupiec-Weglinski JW. PMID: 16436682.
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    103. Gene therapy in liver ischemia and reperfusion injury. Curr Pharm Des. 2006; 12(23):2969-75. Ke B, Lipshutz GS, Kupiec-Weglinski JW. PMID: 16918425.
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    104. Molecular characterization of rat leukocyte P-selectin glycoprotein ligand-1 and effect of its blockade: protection from ischemia-reperfusion injury in liver transplantation. J Immunol. 2006 Jan 01; 176(1):616-24. Tsuchihashi S, Fondevila C, Shaw GD, Lorenz M, Marquette K, Benard S, Shen XD, Ke B, Busuttil RW, Kupiec-Weglinski JW. PMID: 16365457.
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    105. Inhibition of chronic rejection by antibody induced vascular accommodation in fully allogeneic heart allografts. Transplantation. 2005 Dec 15; 80(11):1535-40. Semiletova NV, Shen XD, Baibakov B, Feldman DM, Mukherjee K, Frank JM, Stepkowski SM, Busuttil RW, Kupiec-Weglinski JW, Ghobrial RM. PMID: 16371921.
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    106. Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation. Liver Transpl. 2005 Oct; 11(10):1273-81. Shen XD, Gao F, Ke B, Zhai Y, Lassman CR, Tsuchihashi S, Farmer DG, Busuttil RW, Kupiec-Weglinski JW. PMID: 16184555.
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    107. Disruption of P-selectin signaling modulates cell trafficking and results in improved outcomes after mouse warm intestinal ischemia and reperfusion injury. Transplantation. 2005 Sep 27; 80(6):828-35. Farmer DG, Anselmo D, Da Shen X, Ke B, Carmody IC, Gao F, Lassman C, McDiarmid SV, Shaw G, Busuttil RW, Kupiec-Weglinski JW. PMID: 16210972.
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    108. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant. 2005 Aug; 5(8):1793-800. Shen XD, Ke B, Zhai Y, Gao F, Busuttil RW, Cheng G, Kupiec-Weglinski JW. PMID: 15996225.
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    109. The CD154-CD40 T-cell co-stimulation pathway in liver ischemia and reperfusion inflammatory responses. Transplantation. 2005 May 15; 79(9):1078-83. Ke B, Shen XD, Gao F, Tsuchihashi S, Farmer DG, Briscoe D, Busuttil RW, Kupiec-Weglinski JW. PMID: 15880047.
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    110. Ischemia and reperfusion injury in liver transplantation. Transplant Proc. 2005 May; 37(4):1653-6. Kupiec-Weglinski JW, Busuttil RW. PMID: 15919422.
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    111. CD62 blockade with P-Selectin glycoprotein ligand-immunoglobulin fusion protein reduces ischemia-reperfusion injury after rat intestinal transplantation. Transplantation. 2005 Jan 15; 79(1):44-51. Farmer DG, Shen XD, Amersi F, Anselmo D, Ma JP, Ke B, Gao F, Dry S, Fernandez S, Shaw GD, McDiarmid SV, Busuttil RW, Kupiec-Weglinski J. PMID: 15714168.
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    112. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol. 2004 Dec 15; 173(12):7115-9. Zhai Y, Shen XD, O'Connell R, Gao F, Lassman C, Busuttil RW, Cheng G, Kupiec-Weglinski JW. PMID: 15585830.
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    113. Biliverdin therapy protects rat livers from ischemia and reperfusion injury. Hepatology. 2004 Dec; 40(6):1333-41. Fondevila C, Shen XD, Tsuchiyashi S, Yamashita K, Csizmadia E, Lassman C, Busuttil RW, Kupiec-Weglinski JW, Bach FH. PMID: 15565657.
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    114. Interleukin 13 gene transfer in liver ischemia and reperfusion injury: role of Stat6 and TLR4 pathways in cytoprotection. Hum Gene Ther. 2004 Jul; 15(7):691-8. Ke B, Shen XD, Gao F, Busuttil RW, Kupiec-Weglinski JW. PMID: 15242529.
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    115. National conference to assess antibody-mediated rejection in solid organ transplantation. Am J Transplant. 2004 Jul; 4(7):1033-41. Takemoto SK, Zeevi A, Feng S, Colvin RB, Jordan S, Kobashigawa J, Kupiec-Weglinski J, Matas A, Montgomery RA, Nickerson P, Platt JL, Rabb H, Thistlethwaite R, Tyan D, Delmonico FL. PMID: 15196059.
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    116. Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury. Mol Ther. 2004 Jan; 9(1):38-45. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Ke B, Shen XD, Gao F, Busuttil RW, Löwenstein PR, Castro MG, Kupiec-Weglinski JW. PMID: 14741776; PMCID: PMC2913595.
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    117. Heme oxygenase system in ischemia and reperfusion injury. Ann Transplant. 2004; 9(1):84-7. Tsuchihashi S, Fondevila C, Kupiec-Weglinski JW. PMID: 15478901.
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    118. Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold ischemia/reperfusion injury are heme oxygenase-1 dependent. Am J Transplant. 2003 Sep; 3(9):1076-82. Ke B, Shen XD, Lassman CR, Gao F, Busuttil RW, Kupiec-Weglinski JW. PMID: 12919086.
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    119. Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol. 2003 Aug 01; 171(3):1572-80. Araujo JA, Meng L, Tward AD, Hancock WW, Zhai Y, Lee A, Ishikawa K, Iyer S, Buelow R, Busuttil RW, Shih DM, Lusis AJ, Kupiec-Weglinski JW. PMID: 12874251.
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    120. Interleukin-13 gene transfer protects rat livers from antigen-independent injury induced by ischemia and reperfusion. Transplantation. 2003 Apr 27; 75(8):1118-23. Ke B, Shen XD, Lassman CR, Gao F, Katori M, Busuttil RW, Kupiec-Weglinski JW. PMID: 12717188.
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    121. Fibronectin-alpha 4 beta 1 integrin-mediated blockade protects genetically fat Zucker rat livers from ischemia/reperfusion injury. Am J Pathol. 2003 Apr; 162(4):1229-39. Amersi F, Shen XD, Moore C, Melinek J, Busuttil RW, Kupiec-Weglinski JW, Coito AJ. PMID: 12651615.
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    122. Hepatic ischemia/reperfusion injury--a fresh look. Exp Mol Pathol. 2003 Apr; 74(2):86-93. Fondevila C, Busuttil RW, Kupiec-Weglinski JW. PMID: 12710939.
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    123. Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive. J Immunol. 2003 Mar 15; 170(6):3024-8. Zhai Y, Meng L, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. PMID: 12626556.
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    124. Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury. J Am Soc Nephrol. 2003 Mar; 14(3):745-54. Blydt-Hansen TD, Katori M, Lassman C, Ke B, Coito AJ, Iyer S, Buelow R, Ettenger R, Busuttil RW, Kupiec-Weglinski JW. PMID: 12595512.
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    125. T-cell receptor beta-chain usage in directly activated alloreactive CD4+ T cells: unrestricted Vbeta gene usage with CDR3 size limitations. Transplantation. 2003 Feb 27; 75(4):514-21. Zhai Y, Kupiec-Weglinski JW. PMID: 12605120.
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    126. Posttransplant administration of allochimeric major histocompatibility complex class-I-molecules induces true transplantation tolerance. Transplantation. 2003 Feb 27; 75(4):550-3. Semiltova N, Shen XD, Fishbein MC, Gao F, Slomowitz SJ, Jiao Q, Mukherjee K, Busuttil RW, Kupiec-Weglinski JW, Ghobrial RM. PMID: 12605125.
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    127. Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection. Hepatology. 2003 Feb; 37(2):296-303. Shen XD, Ke B, Zhai Y, Gao F, Anselmo D, Lassman CR, Busuttil RW, Kupiec-Weglinski JW. PMID: 12540779.
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    128. Allograft rejection by primed/memory CD8+ T cells is CD154 blockade resistant: therapeutic implications for sensitized transplant recipients. J Immunol. 2002 Oct 15; 169(8):4667-73. Zhai Y, Meng L, Gao F, Busuttil RW, Kupiec-Weglinski JW. PMID: 12370407.
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    129. Heme oxygenase-1 system in organ transplantation. Transplantation. 2002 Oct 15; 74(7):905-12. Katori M, Busuttil RW, Kupiec-Weglinski JW. PMID: 12394829.
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    130. Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Hum Gene Ther. 2002 Oct 10; 13(15):1845-57. Ke B, Shen XD, Zhai Y, Gao F, Busuttil RW, Volk HD, Kupiec-Weglinski JW. PMID: 12396617.
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    131. FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration. Am J Transplant. 2002 Oct; 2(9):843-9. Anselmo DM, Amersi FF, Shen XD, Gao F, Katori M, Lassman C, Ke B, Coito AJ, Ma J, Brinkmann V, Busuttil RW, Kupiec-Weglinski JW, Farmer DG. PMID: 12392290.
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    132. CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection. Transplantation. 2002 Aug 15; 74(3):315-9. Shen XD, Ke B, Zhai Y, Amersi F, Gao F, Anselmo DM, Busuttil RW, Kupiec-Weglinski JW. PMID: 12177608.
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    133. Upregulation of Bag-1 by ex vivo gene transfer protects rat livers from ischemia/reperfusion injury. Hum Gene Ther. 2002 Aug 10; 13(12):1495-504. Sawitzki B, Amersi F, Ritter T, Fisser M, Shen XD, Ke B, Busuttil R, Volk HD, Kupiec-Weglinski JW. PMID: 12215270.
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    134. The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation. J Immunol. 2002 Aug 01; 169(3):1270-6. Zhai Y, Shen XD, Gao F, Coito AJ, Wasowska BA, Salama A, Schmitt I, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. PMID: 12133948.
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    135. P-selectin glycoprotein ligand-1 (rPSGL-Ig)-mediated blockade of CD62 selectin molecules protects rat steatotic liver grafts from ischemia/reperfusion injury. Am J Transplant. 2002 Aug; 2(7):600-8. Amersi F, Farmer DG, Shaw GD, Kato H, Coito AJ, Kaldas F, Zhao D, Lassman CR, Melinek J, Ma J, Volk HD, Kupiec-Weglinski JW, Busuttil RW. PMID: 12201360.
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    136. Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury. Transplantation. 2002 Jul 15; 74(1):96-102. Coito AJ, Buelow R, Shen XD, Amersi F, Moore C, Volk HD, Busuttil RW, Kupiec-Weglinski JW. PMID: 12134106.
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    137. Heme oxygenase 1 gene transfer prevents CD95/Fas ligand-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway. Hum Gene Ther. 2002 Jul 01; 13(10):1189-99. Ke B, Buelow R, Shen XD, Melinek J, Amersi F, Gao F, Ritter T, Volk HD, Busuttil RW, Kupiec-Weglinski JW. PMID: 12133272.
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    138. Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8915-20. Amersi F, Nelson SK, Shen XD, Kato H, Melinek J, Kupiec-Weglinski JW, Horwitz LD, Busuttil RW, Horwitz MA. PMID: 12084933.
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    139. Immunopathogenesis of accelerated allograft rejection in sensitized recipients: humoral and nonhumoral mechanisms. Transplantation. 2002 May 15; 73(9):1392-7. Hancock WW, Gao W, Shemmeri N, Shen XD, Gao F, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. PMID: 12023615.
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    140. A novel strategy against ischemia and reperfusion injury: cytoprotection with heme oxygenase system. Transpl Immunol. 2002 May; 9(2-4):227-33. Katori M, Anselmo DM, Busuttil RW, Kupiec-Weglinski JW. PMID: 12180835.
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    141. Ex vivo exposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway. Hepatology. 2002 Apr; 35(4):815-23. Amersi F, Shen XD, Anselmo D, Melinek J, Iyer S, Southard DJ, Katori M, Volk HD, Busuttil RW, Buelow R, Kupiec-Weglinski JW. PMID: 11915027.
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    142. Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway. Transplantation. 2002 Jan 27; 73(2):287-92. Katori M, Buelow R, Ke B, Ma J, Coito AJ, Iyer S, Southard D, Busuttil RW, Kupiec-Weglinski JW. PMID: 11821745.
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    143. Selectin-mediated interactions regulate cytokine networks and macrophage heme oxygenase-1 induction in cardiac allograft recipients. Lab Invest. 2002 Jan; 82(1):61-70. Coito AJ, Shaw GD, Li J, Ke B, Ma J, Busuttil RW, Kupiec-Weglinski JW. PMID: 11796826.
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