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Jerzy W Kupiec-Weglinski

Title(s)Professor, Surgery
SchoolMedicine
Phone54196
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    Other Positions
    Title(s)Professor, Pathology and Laboratory Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    Immune Regulation by Stem Cells: Role of Beta-Catenin in Liver Inflammatory Injury
    NIH/NIAID R21AI115133Aug 17, 2017 - Jul 31, 2019
    Role: Co-Principal Investigator
    Innate-Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury
    NIH/NIAID P01AI120944Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    TIM-3 Negative Costimulation Signaling at the Innate-Adaptive Immune interface in Liver Transplant Ischemia-Reperfusion Injury
    NIH/NIDDK R01DK107533Jan 1, 2016 - Dec 31, 2020
    Role: Principal Investigator
    Tim Costimulation in Liver Transplant Ischemia Injury
    NIH/NIDDK R01DK102110Apr 1, 2015 - Mar 31, 2020
    Role: Principal Investigator
    Beta-Catenin Signaling in Liver Ischemia and Reperfusion Injury
    NIH/NIAID R21AI112722Jul 15, 2014 - Jun 30, 2016
    Role: Co-Principal Investigator
    COSTIMULATORY PATHWAYS IN SENSITIZED GRAFT RECIPIENTS
    NIH/NIAID R56AI023847Sep 12, 2009 - Aug 31, 2011
    Role: Principal Investigator
    NRF2 - SIRT1 SIGNALING AXIS IN LIVER TRANSPLANT REJUVENATION
    NIH/NIDDK R01DK062357Jul 1, 2002 - Jan 31, 2014
    Role: Principal Investigator
    CD4+ T REG CELLS IN MAINTENANCE OF TRANSPLANT TOLERANCE
    NIH/NIAID R01AI042223Jul 1, 1998 - Jun 30, 2010
    Role: Principal Investigator
    COSTIMULATORY PATHWAYS SENSITIZED GRAFT RECIPIENTS
    NIH/NIAID R21AI023847Apr 1, 1988 - May 31, 2002
    Role: Principal Investigator
    COSTIMULATORY PATHWAYS IN SENSITIZED GRAFT RECIPIENTS
    NIH/NIAID R01AI023847Apr 1, 1988 - Sep 29, 1991
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sosa RA, Terry AQ, Kaldas FM, Jin YP, Rossetti M, Ito T, Li F, Ahn RS, Naini BV, Groysberg VM, Zheng Y, Aziz A, Nevarez-Mejia J, Zarrinpar A, Busuttil RW, Gjertson DW, Kupiec-Weglinski JW, Reed EF. Disulfide-HMGB1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation. Hepatology. 2020 May 19. PMID: 32426849.
      View in: PubMed
    2. Sosa RA, Rossetti M, Naini BV, Groysberg VM, Kaldas FM, Busuttil RW, Chang YL, Gjertson DW, Kupiec-Weglinski JW, Reed EF. Pattern Recognition Receptor-reactivity Screening of Liver Transplant Patients: Potential for Personalized and Precise Organ Matching to Reduce Risks of Ischemia-reperfusion Injury. Ann Surg. 2020 May; 271(5):922-931. PMID: 30480558.
      View in: PubMed
    3. Nakamura K, Kageyama S, Kaldas FM, Hirao H, Ito T, Kadono K, Dery KJ, Kojima H, Gjertson DW, Sosa RA, Kujawski M, Busuttil RW, Reed EF, Kupiec-Weglinski JW. Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injury. J Clin Invest. 2020 Apr 20. PMID: 32027621.
      View in: PubMed
    4. Xue Z, Zhang Y, Liu Y, Zhang C, Shen XD, Gao F, Busuttil RW, Zheng S, Kupiec-Weglinski JW, Ji H. PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury. Theranostics. 2020; 10(10):4453-4465. PMID: 32292507.
      View in: PubMed
    5. Hirao H, Dery KJ, Kageyama S, Nakamura K, Kupiec-Weglinski JW. Heme Oxygenase-1 in liver transplant ischemia-reperfusion injury: From bench-to-bedside. Free Radic Biol Med. 2020 Feb 19. PMID: 32084514.
      View in: PubMed
    6. Jin D, Lu T, Ni M, Wang H, Zhang J, Zhong C, Shen C, Hao J, Busuttil RW, Kupiec-Weglinski JW, Zhang J, Xu N, Zhai Y. Farnesoid X Receptor Activation Protects Liver From Ischemia/Reperfusion Injury by Up-Regulating Small Heterodimer Partner in Kupffer Cells. Hepatol Commun. 2020 Apr; 4(4):540-554. PMID: 32258949.
      View in: PubMed
    7. Dery KJ, Nakamura K, Kadono K, Hirao H, Kageyama S, Ito T, Kojima H, Kaldas FM, Busuttil RW, Kupiec-Weglinski JW. Human Antigen R (HuR): A New Regulator of Heme Oxygenase-1 Cytoprotection in Mouse and Human Liver Transplant Injury. Hepatology. 2019 Dec 27. PMID: 31879990.
      View in: PubMed
    8. Nakamura K, Kageyama S, Kupiec-Weglinski JW. Innate immunity in ischemia-reperfusion injury and graft rejection. Curr Opin Organ Transplant. 2019 Dec; 24(6):687-693. PMID: 31592839.
      View in: PubMed
    9. Ito T, Nakamura K, Kageyama S, Korayem IM, Hirao H, Kadono K, Aziz J, Younan S, DiNorcia J, Agopian VG, Yersiz H, Farmer DG, Busuttil RW, Kupiec-Weglinski JW, Kaldas FM. Impact of Rifaximin Therapy on Ischemia/Reperfusion Injury in Liver Transplantation: A Propensity Score-Matched Analysis. Liver Transpl. 2019 Dec; 25(12):1778-1789. PMID: 31509643.
      View in: PubMed
    10. Jin Y, Li C, Xu D, Zhu J, Wei S, Zhong A, Sheng M, Duarte S, Coito AJ, Busuttil RW, Xia Q, Kupiec-Weglinski JW, Ke B. Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury. Cell Mol Immunol. 2019 Oct 31. PMID: 31673056.
      View in: PubMed
    11. Whang E, Liu Y, Kageyama S, Woo SL, Yang J, Lee R, Li Z, Ji H, Chen Y, Kupiec-Weglinski JW. Vertical Sleeve Gastrectomy Attenuates the Progression of Non-Alcoholic Steatohepatitis in Mice on a High-Fat High-Cholesterol Diet. Obes Surg. 2019 08; 29(8):2420-2429. PMID: 30982168.
      View in: PubMed
    12. Liu Y, Lu T, Zhang C, Xue Z, Xu J, Busuttil RW, Xia Q, Xu N, Kupiec-Weglinski JW, Ji H. Pituitary Adenylate Cyclase-activating Polypeptides Prevent Hepatocyte Damage by Promoting Yes-associated Protein in Liver Ischemia-Reperfusion Injury. Transplantation. 2019 08; 103(8):1639-1648. PMID: 31348437.
      View in: PubMed
    13. Nakamura K, Kageyama S, Ito T, Hirao H, Kadono K, Aziz A, Dery KJ, Everly MJ, Taura K, Uemoto S, Farmer DG, Kaldas FM, Busuttil RW, Kupiec-Weglinski JW. Antibiotic pretreatment alleviates liver transplant damage in mice and humans. J Clin Invest. 2019 07 22; 129(8):3420-3434. PMID: 31329160.
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    14. Kadono K, Dery KJ, Hirao H, Ito T, Kageyama S, Nakamura K, Oncel D, Aziz A, Kaldas FM, Busuttil RW, Kupiec-Weglinski JW. Heme Oxygenase-1 dictates innate - adaptive immune phenotype in human liver transplantation. Arch Biochem Biophys. 2019 08 15; 671:162-166. PMID: 31299184.
      View in: PubMed
    15. Li C, Jin Y, Wei S, Sun Y, Jiang L, Zhu Q, Farmer DG, Busuttil RW, Kupiec-Weglinski JW, Ke B. Hippo Signaling Controls NLR Family Pyrin Domain Containing 3 Activation and Governs Immunoregulation of Mesenchymal Stem Cells in Mouse Liver Injury. Hepatology. 2019 Nov; 70(5):1714-1731. PMID: 31063235.
      View in: PubMed
    16. Liu Y, Lu T, Zhang C, Xu J, Xue Z, Busuttil RW, Xu N, Xia Q, Kupiec-Weglinski JW, Ji H. Activation of YAP attenuates hepatic damage and fibrosis in liver ischemia-reperfusion injury. J Hepatol. 2019 Oct; 71(4):719-730. PMID: 31201834.
      View in: PubMed
    17. Xu J, Xue Z, Zhang C, Liu Y, Busuttil RW, Zhang J, Kupiec-Weglinski JW, Ji H. Inhibition of Cyclin-dependent Kinase 2 Signaling Prevents Liver Ischemia and Reperfusion Injury. Transplantation. 2019 04; 103(4):724-732. PMID: 30801519.
      View in: PubMed
    18. Nakamura K, Kageyama S, Kupiec-Weglinski JW. The Evolving Role of Neutrophils in Liver Transplant Ischemia-Reperfusion Injury. Curr Transplant Rep. 2019; 6(1):78-89. PMID: 31602356.
      View in: PubMed
    19. Zhang M, Nakamura K, Kageyama S, Lawal AO, Gong KW, Bhetraratana M, Fujii T, Sulaiman D, Hirao H, Bolisetty S, Kupiec-Weglinski JW, Araujo JA. Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury. JCI Insight. 2018 10 04; 3(19). PMID: 30282830.
      View in: PubMed
    20. Kageyama S, Hirao H, Nakamura K, Ke B, Zhang M, Ito T, Aziz A, Oncel D, Kaldas FM, Busuttil RW, Sosa RA, Reed EF, Araujo JA, Kupiec-Weglinski JW. Recipient HO-1 inducibility is essential for posttransplant hepatic HO-1 expression and graft protection: From bench-to-bedside. Am J Transplant. 2019 02; 19(2):356-367. PMID: 30059195.
      View in: PubMed
    21. Nakamura K, Zhang M, Kageyama S, Ke B, Araujo JA, Kupiec-Weglinski JW. Reply to: "Protective effects of heme oxygenase 1 during ischemia-reperfusion injury: Hepatocytes or non parenchymal cells?" J Hepatol. 2018 09; 69(3):753-755. PMID: 29870762.
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    22. Ke B, Kupiec-Weglinski JW. Lipid Metabolites: The Alarm Signal to Trigger Liver Ischemia-reperfusion Injury. Transplantation. 2018 06; 102(6):887-889. PMID: 29782474.
      View in: PubMed
    23. Kageyama S, Nakamura K, Fujii T, Ke B, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. Recombinant relaxin protects liver transplants from ischemia damage by hepatocyte glucocorticoid receptor: From bench-to-bedside. Hepatology. 2018 07; 68(1):258-273. PMID: 29350771.
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    24. Kageyama S, Nakamura K, Ke B, Busuttil RW, Kupiec-Weglinski JW. Serelaxin induces Notch1 signaling and alleviates hepatocellular damage in orthotopic liver transplantation. Am J Transplant. 2018 07; 18(7):1755-1763. PMID: 29464890.
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    25. Zhou H, Wang H, Ni M, Yue S, Xia Y, Busuttil RW, Kupiec-Weglinski JW, Lu L, Wang X, Zhai Y. Glycogen synthase kinase 3ß promotes liver innate immune activation by restraining AMP-activated protein kinase activation. J Hepatol. 2018 07; 69(1):99-109. PMID: 29452207.
      View in: PubMed
    26. Lu L, Yue S, Jiang L, Li C, Zhu Q, Ke M, Lu H, Wang X, Busuttil RW, Ying QL, Kupiec-Weglinski JW, Ke B. Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers. Hepatology. 2018 03; 67(3):1041-1055. PMID: 29024000.
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    27. Nakamura K, Kageyama S, Yue S, Huang J, Fujii T, Ke B, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation: From mouse to human. Am J Transplant. 2018 05; 18(5):1110-1121. PMID: 29136322.
      View in: PubMed
    28. Salehi S, Sosa RA, Jin YP, Kageyama S, Fishbein MC, Rozengurt E, Kupiec-Weglinski JW, Reed EF. Outside-in HLA class I signaling regulates ICAM-1 clustering and endothelial cell-monocyte interactions via mTOR in transplant antibody-mediated rejection. Am J Transplant. 2018 05; 18(5):1096-1109. PMID: 29045076.
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    29. Nakamura K, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/Reperfusion: From mouse to human. Liver Transpl. 2017 10; 23(10):1282-1293. PMID: 28719070.
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    30. Nakamura K, Zhang M, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury. J Hepatol. 2017 12; 67(6):1232-1242. PMID: 28842295.
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    31. Zhu Q, Li C, Wang K, Yue S, Jiang L, Ke M, Busuttil RW, Kupiec-Weglinski JW, Zhang F, Lu L, Ke B. Phosphatase and tensin homolog-ß-catenin signaling modulates regulatory T cells and inflammatory responses in mouse liver ischemia/reperfusion injury. Liver Transpl. 2017 06; 23(6):813-825. PMID: 28152578.
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    32. Yue S, Zhou H, Wang X, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury. J Immunol. 2017 05 01; 198(9):3588-3595. PMID: 28289160.
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    33. Palumbo T, Nakamura K, Lassman C, Kidani Y, Bensinger SJ, Busuttil R, Kupiec-Weglinski J, Zarrinpar A. Bruton Tyrosine Kinase Inhibition Attenuates Liver Damage in a Mouse Warm Ischemia and Reperfusion Model. Transplantation. 2017 02; 101(2):322-331. PMID: 27820779.
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    34. Sosa RA, Zarrinpar A, Rossetti M, Lassman CR, Naini BV, Datta N, Rao P, Harre N, Zheng Y, Spreafico R, Hoffmann A, Busuttil RW, Gjertson DW, Zhai Y, Kupiec-Weglinski JW, Reed EF. Early cytokine signatures of ischemia/reperfusion injury in human orthotopic liver transplantation. JCI Insight. 2016 12 08; 1(20):e89679. PMID: 27942590.
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    35. Lu L, Zhou H, Ni M, Wang X, Busuttil R, Kupiec-Weglinski J, Zhai Y. Innate Immune Regulations and Liver Ischemia-Reperfusion Injury. Transplantation. 2016 Dec; 100(12):2601-2610. PMID: 27861288.
      View in: PubMed
    36. Yue S, Zhu J, Zhang M, Li C, Zhou X, Zhou M, Ke M, Busuttil RW, Ying QL, Kupiec-Weglinski JW, Xia Q, Ke B. The myeloid heat shock transcription factor 1/ß-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury. Hepatology. 2016 11; 64(5):1683-1698. PMID: 27474884.
      View in: PubMed
    37. Zhou H, Zhu J, Yue S, Lu L, Busuttil RW, Kupiec-Weglinski JW, Wang X, Zhai Y. The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury. Transplantation. 2016 Feb; 100(2):365-72. PMID: 26683513.
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    38. Liu Y, Ji H, Zhang Y, Shen XD, Gao F, Nguyen TT, Shang X, Lee N, Busuttil RW, Kupiec-Weglinski JW. Negative CD4?+?TIM-3 signaling confers resistance against cold preservation damage in mouse liver transplantation. Am J Transplant. 2015 Apr; 15(4):954-964. PMID: 25676534.
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    39. Zhu J, Lu T, Yue S, Shen X, Gao F, Busuttil RW, Kupiec-Weglinski JW, Xia Q, Zhai Y. Rapamycin protection of livers from ischemia and reperfusion injury is dependent on both autophagy induction and mammalian target of rapamycin complex 2-Akt activation. Transplantation. 2015 Jan; 99(1):48-55. PMID: 25340604.
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    40. Liu Y, Ji H, Zhang Y, Shen X, Gao F, He X, Li GA, Busuttil RW, Kuchroo VK, Kupiec-Weglinski JW. Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury. J Hepatol. 2015 Mar; 62(3):563-72. PMID: 25450716.
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    41. Ji H, Liu Y, Zhang Y, Shen XD, Gao F, Busuttil RW, Kuchroo VK, Kupiec-Weglinski JW. T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury. Hepatology. 2014 Dec; 60(6):2052-2064. PMID: 25066922.
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    42. Huang J, Yue S, Ke B, Zhu J, Shen XD, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network. Transplantation. 2014 Oct 15; 98(7):721-8. PMID: 25171655.
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    43. Huang J, Shen XD, Yue S, Zhu J, Gao F, Zhai Y, Busuttil RW, Ke B, Kupiec-Weglinski JW. Adoptive transfer of heme oxygenase-1 (HO-1)-modified macrophages rescues the nuclear factor erythroid 2-related factor (Nrf2) antiinflammatory phenotype in liver ischemia/reperfusion injury. Mol Med. 2014 Oct 14; 20:448-55. PMID: 25014792.
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    44. Yue S, Rao J, Zhu J, Busuttil RW, Kupiec-Weglinski JW, Lu L, Wang X, Zhai Y. Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation. J Immunol. 2014 Jun 01; 192(11):5343-5353. PMID: 24771857.
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    45. Farrar CA, Kupiec-Weglinski JW, Sacks SH. The innate immune system and transplantation. Cold Spring Harb Perspect Med. 2013 Oct 01; 3(10):a015479. PMID: 24086066.
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    46. Ji H, Zhang Y, Liu Y, Shen XD, Gao F, Nguyen TT, Busuttil RW, Waschek JA, Kupiec-Weglinski JW. Vasoactive intestinal peptide attenuates liver ischemia/reperfusion injury in mice via the cyclic adenosine monophosphate-protein kinase a pathway. Liver Transpl. 2013 Sep; 19(9):945-56. PMID: 23744729.
      View in: PubMed
    47. Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. J Hepatol. 2013 Dec; 59(6):1200-7. PMID: 23867319.
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    48. Kamo N, Ke B, Ghaffari AA, Shen XD, Busuttil RW, Cheng G, Kupiec-Weglinski JW. ASC/caspase-1/IL-1ß signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatology. 2013 Jul; 58(1):351-62. PMID: 23408710.
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    49. Ke B, Shen XD, Kamo N, Ji H, Yue S, Gao F, Busuttil RW, Kupiec-Weglinski JW. ß-catenin regulates innate and adaptive immunity in mouse liver ischemia-reperfusion injury. Hepatology. 2013 Mar; 57(3):1203-14. PMID: 23081841.
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    50. Ji H, Zhang Y, Shen XD, Gao F, Huang CY, Abad C, Busuttil RW, Waschek JA, Kupiec-Weglinski JW. Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation by the cAMP-PKA pathway. Hepatology. 2013 Mar; 57(3):1225-37. PMID: 22532103.
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    51. Kosieradzki M, Pratschke J, Kupiec-Weglinski J, Rowinski W. Ischemia/Reperfusion injury, its mechanisms, and prevention. J Transplant. 2012; 2012:610370. PMID: 23320144.
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    52. Zhai Y, Petrowsky H, Hong JC, Busuttil RW, Kupiec-Weglinski JW. Ischaemia-reperfusion injury in liver transplantation--from bench to bedside. Nat Rev Gastroenterol Hepatol. 2013 Feb; 10(2):79-89. PMID: 23229329.
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    53. Kamo N, Ke B, Busuttil RW, Kupiec-Weglinski JW. PTEN-mediated Akt/ß-catenin/Foxo1 signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury. Hepatology. 2013 Jan; 57(1):289-98. PMID: 22807038.
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    54. Liu J, Ren F, Cheng Q, Bai L, Shen X, Gao F, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury. Transplantation. 2012 Aug 15; 94(3):211-7. PMID: 22790388.
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    55. Ji H, Shen XD, Zhang Y, Gao F, Huang CY, Chang WW, Lee C, Ke B, Busuttil RW, Kupiec-Weglinski JW. Activation of cyclic adenosine monophosphate-dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice. Liver Transpl. 2012 Jun; 18(6):659-70. PMID: 22290937.
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    56. Watson MJ, Ke B, Shen XD, Gao F, Busuttil RW, Kupiec-Weglinski JW, Farmer DG. Treatment with antithymocyte globulin ameliorates intestinal ischemia and reperfusion injury in mice. Surgery. 2012 Nov; 152(5):843-50. PMID: 22575884.
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    57. Chestovich PJ, Uchida Y, Chang W, Ajalat M, Lassman C, Sabat R, Busuttil RW, Kupiec-Weglinski JW. Interleukin-22: implications for liver ischemia-reperfusion injury. Transplantation. 2012 Mar 15; 93(5):485-92. PMID: 22262131.
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    58. Hong JC, Koroleff D, Xia V, Chang CM, Duarte SM, Xu J, Lassman C, Kupiec-Weglinski J, Coito AJ, Busuttil RW. Regulated hepatic reperfusion mitigates ischemia-reperfusion injury and improves survival after prolonged liver warm ischemia: a pilot study on a novel concept of organ resuscitation in a large animal model. J Am Coll Surg. 2012 Apr; 214(4):505-15; discussion 515-6. PMID: 22321520.
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    59. Freitas MC, Uchida Y, Lassman C, Danovitch GM, Busuttil RW, Kupiec-Weglinski JW. Type I interferon pathway mediates renal ischemia/reperfusion injury. Transplantation. 2011 Jul 27; 92(2):131-8. PMID: 21577179.
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    60. Ke B, Shen XD, Ji H, Kamo N, Gao F, Freitas MC, Busuttil RW, Kupiec-Weglinski JW. HO-1-STAT3 axis in mouse liver ischemia/reperfusion injury: regulation of TLR4 innate responses through PI3K/PTEN signaling. J Hepatol. 2012 Feb; 56(2):359-66. PMID: 21756853.
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    61. Ren F, Duan Z, Cheng Q, Shen X, Gao F, Bai L, Liu J, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism. Hepatology. 2011 Aug; 54(2):687-96. PMID: 21567437.
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    62. Ji H, Shen XD, Gao F, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. Alloreactive CD8 T-cell primed/memory responses and accelerated graft rejection in B-cell-deficient sensitized mice. Transplantation. 2011 May 27; 91(10):1075-81. PMID: 21427633.
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    63. Farmer DG, Ke B, Shen XD, Kaldas FM, Gao F, Watson MJ, Busuttil RW, Kupiec-Weglinski JW. Interleukin-13 protects mouse intestine from ischemia and reperfusion injury through regulation of innate and adaptive immunity. Transplantation. 2011 Apr 15; 91(7):737-43. PMID: 21311412.
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    64. Shen XD, Ke B, Uchida Y, Ji H, Gao F, Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury. Liver Transpl. 2011 Feb; 17(2):201-10. PMID: 21280193.
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    65. Ji H, Shen X, Gao F, Ke B, Freitas MC, Uchida Y, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury. Hepatology. 2010 Oct; 52(4):1380-9. PMID: 20815020.
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    66. Uchida Y, Ke B, Freitas MC, Yagita H, Akiba H, Busuttil RW, Najafian N, Kupiec-Weglinski JW. T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner. Gastroenterology. 2010 Dec; 139(6):2195-206. PMID: 20637206.
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    67. Uchida Y, Freitas MC, Zhao D, Busuttil RW, Kupiec-Weglinski JW. The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. Transplantation. 2010 May 15; 89(9):1050-6. PMID: 20160675.
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    68. Freitas MC, Uchida Y, Zhao D, Ke B, Busuttil RW, Kupiec-Weglinski JW. Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion. Liver Transpl. 2010 May; 16(5):600-10. PMID: 20440769.
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    69. Uchida Y, Ke B, Freitas MC, Ji H, Zhao D, Benjamin ER, Najafian N, Yagita H, Akiba H, Busuttil RW, Kupiec-Weglinski JW. The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse. Hepatology. 2010 Apr; 51(4):1363-72. PMID: 20091883.
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    70. Ke B, Shen XD, Gao F, Ji H, Qiao B, Zhai Y, Farmer DG, Busuttil RW, Kupiec-Weglinski JW. Adoptive transfer of ex vivo HO-1 modified bone marrow-derived macrophages prevents liver ischemia and reperfusion injury. Mol Ther. 2010 May; 18(5):1019-25. PMID: 20029397.
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    71. Shen X, Wang Y, Gao F, Ren F, Busuttil RW, Kupiec-Weglinski JW, Zhai Y. CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury. Hepatology. 2009 Nov; 50(5):1537-46. PMID: 19670423.
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    81. Jindra PT, Hsueh A, Hong L, Gjertson D, Shen XD, Gao F, Dang J, Mischel PS, Baldwin WM, Fishbein MC, Kupiec-Weglinski JW, Reed EF. Anti-MHC class I antibody activation of proliferation and survival signaling in murine cardiac allografts. J Immunol. 2008 Feb 15; 180(4):2214-24. PMID: 18250428.
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    82. Zhai Y, Shen XD, Gao F, Zhao A, Freitas MC, Lassman C, Luster AD, Busuttil RW, Kupiec-Weglinski JW. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Hepatology. 2008 Jan; 47(1):207-14. PMID: 18041715.
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    83. Zhai Y, Qiao B, Gao F, Shen X, Vardanian A, Busuttil RW, Kupiec-Weglinski JW. Type I, but not type II, interferon is critical in liver injury induced after ischemia and reperfusion. Hepatology. 2008 Jan; 47(1):199-206. PMID: 17935177.
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    84. Semiletova NV, Shen XD, Feldman DM, Gao F, Mhoyan A, Liu D, Busuttil RW, Kupiec-Weglinski JW, Ghobrial RM. Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strains. Cell Immunol. 2007 Jul; 248(1):48-58. PMID: 17936255.
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    88. Ke B, Shen XD, Tsuchihashi S, Gao F, Araujo JA, Busuttil RW, Ritter T, Kupiec-Weglinski JW. Viral interleukin-10 gene transfer prevents liver ischemia-reperfusion injury: Toll-like receptor-4 and heme oxygenase-1 signaling in innate and adaptive immunity. Hum Gene Ther. 2007 Apr; 18(4):355-66. PMID: 17439357.
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    89. Hoglen NC, Anselmo DM, Katori M, Kaldas M, Shen XD, Valentino KL, Lassman C, Busuttil RW, Kupiec-Weglinski JW, Farmer DG. A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia. Liver Transpl. 2007 Mar; 13(3):361-6. PMID: 17318854.
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    90. Tsuchihashi S, Livhits M, Zhai Y, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. Basal rather than induced heme oxygenase-1 levels are crucial in the antioxidant cytoprotection. J Immunol. 2006 Oct 01; 177(7):4749-57. PMID: 16982915.
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    97. Semiletova NV, Shen XD, Baibakov B, Feldman DM, Mukherjee K, Frank JM, Stepkowski SM, Busuttil RW, Kupiec-Weglinski JW, Ghobrial RM. Inhibition of chronic rejection by antibody induced vascular accommodation in fully allogeneic heart allografts. Transplantation. 2005 Dec 15; 80(11):1535-40. PMID: 16371921.
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    105. Fondevila C, Shen XD, Tsuchiyashi S, Yamashita K, Csizmadia E, Lassman C, Busuttil RW, Kupiec-Weglinski JW, Bach FH. Biliverdin therapy protects rat livers from ischemia and reperfusion injury. Hepatology. 2004 Dec; 40(6):1333-41. PMID: 15565657.
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    107. Takemoto SK, Zeevi A, Feng S, Colvin RB, Jordan S, Kobashigawa J, Kupiec-Weglinski J, Matas A, Montgomery RA, Nickerson P, Platt JL, Rabb H, Thistlethwaite R, Tyan D, Delmonico FL. National conference to assess antibody-mediated rejection in solid organ transplantation. Am J Transplant. 2004 Jul; 4(7):1033-41. PMID: 15196059.
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    113. Amersi F, Shen XD, Moore C, Melinek J, Busuttil RW, Kupiec-Weglinski JW, Coito AJ. Fibronectin-alpha 4 beta 1 integrin-mediated blockade protects genetically fat Zucker rat livers from ischemia/reperfusion injury. Am J Pathol. 2003 Apr; 162(4):1229-39. PMID: 12651615.
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    115. Zhai Y, Meng L, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive. J Immunol. 2003 Mar 15; 170(6):3024-8. PMID: 12626556.
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    119. Shen XD, Ke B, Zhai Y, Gao F, Anselmo D, Lassman CR, Busuttil RW, Kupiec-Weglinski JW. Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection. Hepatology. 2003 Feb; 37(2):296-303. PMID: 12540779.
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    120. Zhai Y, Meng L, Gao F, Busuttil RW, Kupiec-Weglinski JW. Allograft rejection by primed/memory CD8+ T cells is CD154 blockade resistant: therapeutic implications for sensitized transplant recipients. J Immunol. 2002 Oct 15; 169(8):4667-73. PMID: 12370407.
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    122. Ke B, Shen XD, Zhai Y, Gao F, Busuttil RW, Volk HD, Kupiec-Weglinski JW. Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Hum Gene Ther. 2002 Oct 10; 13(15):1845-57. PMID: 12396617.
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    125. Sawitzki B, Amersi F, Ritter T, Fisser M, Shen XD, Ke B, Busuttil R, Volk HD, Kupiec-Weglinski JW. Upregulation of Bag-1 by ex vivo gene transfer protects rat livers from ischemia/reperfusion injury. Hum Gene Ther. 2002 Aug 10; 13(12):1495-504. PMID: 12215270.
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    126. Zhai Y, Shen XD, Gao F, Coito AJ, Wasowska BA, Salama A, Schmitt I, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation. J Immunol. 2002 Aug 01; 169(3):1270-6. PMID: 12133948.
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    128. Coito AJ, Buelow R, Shen XD, Amersi F, Moore C, Volk HD, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury. Transplantation. 2002 Jul 15; 74(1):96-102. PMID: 12134106.
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    130. Amersi F, Nelson SK, Shen XD, Kato H, Melinek J, Kupiec-Weglinski JW, Horwitz LD, Busuttil RW, Horwitz MA. Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8915-20. PMID: 12084933.
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    131. Hancock WW, Gao W, Shemmeri N, Shen XD, Gao F, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. Immunopathogenesis of accelerated allograft rejection in sensitized recipients: humoral and nonhumoral mechanisms. Transplantation. 2002 May 15; 73(9):1392-7. PMID: 12023615.
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    134. Katori M, Buelow R, Ke B, Ma J, Coito AJ, Iyer S, Southard D, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway. Transplantation. 2002 Jan 27; 73(2):287-92. PMID: 11821745.
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    135. Coito AJ, Shaw GD, Li J, Ke B, Ma J, Busuttil RW, Kupiec-Weglinski JW. Selectin-mediated interactions regulate cytokine networks and macrophage heme oxygenase-1 induction in cardiac allograft recipients. Lab Invest. 2002 Jan; 82(1):61-70. PMID: 11796826.
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