Jesus A Araujo

Title(s)Professor, Medicine
SchoolMedicine
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    Interplay Between Macrophages, Lipid Oxidation and the Nrf2/HO-1 Axis in the Cardiometabolic Toxicity Induced by Ultrafine Particles
    NIH R01ES032806May 8, 2021 - Feb 28, 2026
    Role: Principal Investigator
    Role of Intestinal Microbiota in Dyslipidemia and Atherosclerosis Induced by Ambient Ultrafine Particles
    NIH R01ES029395Sep 30, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Air Pollution and Cardiovascular Diseases: Identification of Novel Biomarkers
    NIH R21ES024560May 1, 2015 - Apr 30, 2018
    Role: Co-Principal Investigator
    Effects of particulate air pollution on HDL function and atherosclerosis
    NIH R01ES016959Sep 21, 2009 - Sep 21, 2014
    Role: Principal Investigator
    Effects of particulate air pollution on HDL function and athersclerosis
    NIH R56ES016959Jul 1, 2008 - Aug 31, 2016
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Key Characteristics of Cardiovascular Toxicants. Environ Health Perspect. 2021 Sep; 129(9):95001. Lind L, Araujo JA, Barchowsky A, Belcher S, Berridge BR, Chiamvimonvat N, Chiu WA, Cogliano VJ, Elmore S, Farraj AK, Gomes AV, McHale CM, Meyer-Tamaki KB, Posnack NG, Vargas HM, Yang X, Zeise L, Zhou C, Smith MT. PMID: 34558968; PMCID: PMC8462506.
      View in: PubMed   Mentions:
    2. Differential Effects of Electronic Hookah Vaping and Traditional Combustible Hookah Smoking on Oxidation, Inflammation, and Arterial Stiffness. Chest. 2022 Jan; 161(1):208-218. Rezk-Hanna M, Gupta R, Nettle CO, Dobrin D, Cheng CW, Means A, Brecht ML, Tashkin DP, Araujo JA. PMID: 34298007.
      View in: PubMed   Mentions:
    3. Electronic and Tobacco Cigarettes Alter Polyunsaturated Fatty Acids and Oxidative Biomarkers. Circ Res. 2021 Aug 20; 129(5):514-526. Gupta R, Lin Y, Luna K, Logue A, Yoon AJ, Haptonstall KP, Moheimani R, Choroomi Y, Nguyen K, Tran E, Zhu Y, Faull KF, Kelesidis T, Gornbein J, Middlekauff HR, Araujo JA. PMID: 34187173; PMCID: PMC8376792.
      View in: PubMed   Mentions:    Fields:    
    4. Metabolomic Changes after Subacute Exposure to Polycyclic Aromatic Hydrocarbons: A Natural Experiment among Healthy Travelers from Los Angeles to Beijing. Environ Sci Technol. 2021 04 20; 55(8):5097-5105. Lu X, Lin Y, Qiu X, Liu J, Zhu T, Araujo JA, Zhang J, Zhu Y. PMID: 33683876.
      View in: PubMed   Mentions:
    5. Ascorbic Acid Prevents Vascular Endothelial Dysfunction Induced by Electronic Hookah (Waterpipe) Vaping. J Am Heart Assoc. 2021 02; 10(5):e019271. Rezk-Hanna M, Seals DR, Rossman MJ, Gupta R, Nettle CO, Means A, Dobrin D, Cheng CW, Brecht ML, Mosenifar Z, Araujo JA, Benowitz NL. PMID: 33615833; PMCID: PMC8174254.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Urinary carboxylic acid metabolites as possible novel biomarkers of exposures to alkylated polycyclic aromatic hydrocarbons. Environ Int. 2021 02; 147:106325. Lin Y, Gao X, Qiu X, Liu J, Tseng CH, Zhang JJ, Araujo JA, Zhu Y. PMID: 33340988.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    7. Changes in lipid composition associated with electronic cigarette use. J Transl Med. 2020 10 07; 18(1):379. Middlekauff HR, William KJ, Su B, Haptonstall K, Araujo JA, Wu X, Kim J, Sallam T. PMID: 33028369; PMCID: PMC7542424.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Diesel Exhaust Extract Exposure Induces Neuronal Toxicity by Disrupting Autophagy. Toxicol Sci. 2020 07 01; 176(1):193-202. Barnhill LM, Khuansuwan S, Juarez D, Murata H, Araujo JA, Bronstein JM. PMID: 32298450; PMCID: PMC7357183.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    9. Different temporal trends of exposure to Bisphenol A among international travelers between Los Angeles and Beijing. Environ Int. 2020 08; 141:105758. Lin Y, Qiu X, Liu J, Tseng CH, Allard P, Araujo JA, Zhu Y. PMID: 32402980; PMCID: PMC7283011.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Pro-Oxidative and Proinflammatory Effects After Traveling From Los Angeles to Beijing: A Biomarker-Based Natural Experiment. Circulation. 2019 12 10; 140(24):1995-2004. Lin Y, Ramanathan G, Zhu Y, Yin F, Rea ND, Lu X, Tseng CH, Faull KF, Yoon AJ, Jerrett M, Zhu T, Qiu X, Araujo JA. PMID: 31744317.
      View in: PubMed   Mentions:
    11. Diesel exhaust particles dysregulate multiple immunological pathways in murine macrophages: Lessons from microarray and scRNA-seq technologies. Arch Biochem Biophys. 2019 12 15; 678:108116. Bhetraratana M, Orozco LD, Hong J, Diamante G, Majid S, Bennett BJ, Ahn IS, Yang X, Lusis AJ, Araujo JA. PMID: 31568751; PMCID: PMC7984963.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice. Sci Rep. 2019 02 12; 9(1):1816. Woodward NC, Crow AL, Zhang Y, Epstein S, Hartiala J, Johnson R, Kocalis H, Saffari A, Sankaranarayanan I, Akbari O, Ramanathan G, Araujo JA, Finch CE, Bouret SG, Sioutas C, Morgan TE, Allayee H. PMID: 30755631; PMCID: PMC6372675.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    13. Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury. JCI Insight. 2018 10 04; 3(19). Zhang M, Nakamura K, Kageyama S, Lawal AO, Gong KW, Bhetraratana M, Fujii T, Sulaiman D, Hirao H, Bolisetty S, Kupiec-Weglinski JW, Araujo JA. PMID: 30282830; PMCID: PMC6237471.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    14. Recipient HO-1 inducibility is essential for posttransplant hepatic HO-1 expression and graft protection: From bench-to-bedside. Am J Transplant. 2019 02; 19(2):356-367. Kageyama S, Hirao H, Nakamura K, Ke B, Zhang M, Ito T, Aziz A, Oncel D, Kaldas FM, Busuttil RW, Sosa RA, Reed EF, Araujo JA, Kupiec-Weglinski JW. PMID: 30059195; PMCID: PMC6349504.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. Reply to: "Protective effects of heme oxygenase 1 during ischemia-reperfusion injury: Hepatocytes or non parenchymal cells?" J Hepatol. 2018 09; 69(3):753-755. Nakamura K, Zhang M, Kageyama S, Ke B, Araujo JA, Kupiec-Weglinski JW. PMID: 29870762.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. Increased Cardiovascular Risk Associated With E-Cigarette Use-Reply. JAMA Cardiol. 2017 10 01; 2(10):1166-1167. Middlekauff HR, Araujo JA. PMID: 28593271.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Sympathomimetic Effects of Acute E-Cigarette Use: Role of Nicotine and Non-Nicotine Constituents. J Am Heart Assoc. 2017 Sep 20; 6(9). Moheimani RS, Bhetraratana M, Peters KM, Yang BK, Yin F, Gornbein J, Araujo JA, Middlekauff HR. PMID: 28931527; PMCID: PMC5634299.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    18. Activation of the "Splenocardiac Axis" by electronic and tobacco cigarettes in otherwise healthy young adults. Physiol Rep. 2017 Sep; 5(17). Boas Z, Gupta P, Moheimani RS, Bhetraratana M, Yin F, Peters KM, Gornbein J, Araujo JA, Czernin J, Middlekauff HR. PMID: 28899908; PMCID: PMC5599858.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury. J Hepatol. 2017 12; 67(6):1232-1242. Nakamura K, Zhang M, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. PMID: 28842295; PMCID: PMC5884687.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    20. Increased Cardiac Sympathetic Activity and Oxidative Stress in Habitual Electronic Cigarette Users: Implications for Cardiovascular Risk. JAMA Cardiol. 2017 03 01; 2(3):278-284. Moheimani RS, Bhetraratana M, Yin F, Peters KM, Gornbein J, Araujo JA, Middlekauff HR. PMID: 28146259; PMCID: PMC5626008.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    21. Effects of urban fine particulate matter and ozone on HDL functionality. Part Fibre Toxicol. 2016 05 24; 13(1):26. Ramanathan G, Yin F, Speck M, Tseng CH, Brook JR, Silverman F, Urch B, Brook RD, Araujo JA. PMID: 27221567; PMCID: PMC4879751.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    22. Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A Biomarker-Based Study between Los Angeles and Beijing. Environ Sci Technol. 2016 Apr 05; 50(7):3738-45. Lin Y, Qiu X, Yu N, Yang Q, Araujo JA, Zhu Y. PMID: 26913796; PMCID: PMC6057150.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsPHPublic Health
    23. Heme oxygenase-1 protects endothelial cells from the toxicity of air pollutant chemicals. Toxicol Appl Pharmacol. 2015 May 01; 284(3):281-291. Lawal A, Zhang M, Dittmar M, Lulla A, Araujo JA. PMID: 25620054; PMCID: PMC4743257.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    24. Cigarette smoking is associated with dose-dependent adverse effects on paraoxonase activity and fibrinogen in young women. Inhal Toxicol. 2014 Dec; 26(14):861-5. Ramanathan G, Araujo JA, Gornbein J, Yin F, Middlekauff HR. PMID: 25472476; PMCID: PMC4266070.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. Effect of exposure to atmospheric ultrafine particles on production of free fatty acids and lipid metabolites in the mouse small intestine. Environ Health Perspect. 2015 Jan; 123(1):34-41. Li R, Navab K, Hough G, Daher N, Zhang M, Mittelstein D, Lee K, Pakbin P, Saffari A, Bhetraratana M, Sulaiman D, Beebe T, Wu L, Jen N, Wine E, Tseng CH, Araujo JA, Fogelman A, Sioutas C, Navab M, Hsiai TK. PMID: 25170928; PMCID: PMC4286268.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsPHPublic Health
    26. No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function. Inhal Toxicol. 2014 Jan; 26(1):23-9. Maiseyeu A, Yang HY, Ramanathan G, Yin F, Bard RL, Morishita M, Dvonch JT, Wang L, Spino C, Mukherjee B, Badgeley MA, Barajas-Espinosa A, Sun Q, Harkema J, Rajagopalan S, Araujo JA, Brook RD. PMID: 24417404; PMCID: PMC4445365.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    27. Diesel exhaust particulate increases the size and complexity of lesions in atherosclerotic mice. Part Fibre Toxicol. 2013 Dec 11; 10:61. Miller MR, McLean SG, Duffin R, Lawal AO, Araujo JA, Shaw CA, Mills NL, Donaldson K, Newby DE, Hadoke PW. PMID: 24330719; PMCID: PMC3907045.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    28. HDL anti-oxidant function associates with LDL level in young adults. Atherosclerosis. 2014 Jan; 232(1):165-70. Breton CV, Yin F, Wang X, Avol E, Gilliland FD, Araujo JA. PMID: 24401232; PMCID: PMC4039385.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    29. HO-1 and CO: fighters vs sickle cell disease? Blood. 2013 Oct 10; 122(15):2535-6. Araujo JA. PMID: 24113796; PMCID: PMC3795456.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    30. Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice. J Lipid Res. 2013 Jun; 54(6):1608-1615. Li R, Navab M, Pakbin P, Ning Z, Navab K, Hough G, Morgan TE, Finch CE, Araujo JA, Fogelman AM, Sioutas C, Hsiai T. PMID: 23564731; PMCID: PMC3646462.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    31. Diesel exhaust induces systemic lipid peroxidation and development of dysfunctional pro-oxidant and pro-inflammatory high-density lipoprotein. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1153-61. Yin F, Lawal A, Ricks J, Fox JR, Larson T, Navab M, Fogelman AM, Rosenfeld ME, Araujo JA. PMID: 23559632.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCellsPHPublic Health
    32. Prooxidative effects of ambient pollutant chemicals are inhibited by HDL. J Biochem Mol Toxicol. 2013 Feb; 27(2):172-83. Yin F, Ramanathan G, Zhang M, Araujo JA. PMID: 23420698.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    33. Heme oxygenase-1, oxidation, inflammation, and atherosclerosis. Front Pharmacol. 2012; 3:119. Araujo JA, Zhang M, Yin F. PMID: 22833723; PMCID: PMC3400084.
      View in: PubMed   Mentions: 112  
    34. Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1. Circ Res. 2011 Aug 19; 109(5):e27-41. Romanoski CE, Che N, Yin F, Mai N, Pouldar D, Civelek M, Pan C, Lee S, Vakili L, Yang WP, Kayne P, Mungrue IN, Araujo JA, Berliner JA, Lusis AJ. PMID: 21737788; PMCID: PMC3163234.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    35. Are ultrafine particles a risk factor for cardiovascular diseases? Rev Esp Cardiol. 2011 Aug; 64(8):642-5. Araujo JA. PMID: 21723025.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis. Air Qual Atmos Health. 2010 Nov 10; 4(1):79-93. Araujo JA. PMID: 21461032; PMCID: PMC3040314.
      View in: PubMed   Mentions: 52  
    37. NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):58-66. Barajas B, Che N, Yin F, Rowshanrad A, Orozco LD, Gong KW, Wang X, Castellani LW, Reue K, Lusis AJ, Araujo JA. PMID: 20947826; PMCID: PMC3037185.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    38. Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress. Part Fibre Toxicol. 2009 Sep 18; 6:24. Araujo JA, Nel AE. PMID: 19761620; PMCID: PMC2761850.
      View in: PubMed   Mentions: 78     Fields:    
    39. Particulate matter induced enhancement of inflammatory markers in the brains of apolipoprotein E knockout mice. J Nanosci Nanotechnol. 2009 Aug; 9(8):5099-104. Campbell A, Araujo JA, Li H, Sioutas C, Kleinman M. PMID: 19928188.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    40. Copy number variation influences gene expression and metabolic traits in mice. Hum Mol Genet. 2009 Nov 01; 18(21):4118-29. Orozco LD, Cokus SJ, Ghazalpour A, Ingram-Drake L, Wang S, van Nas A, Che N, Araujo JA, Pellegrini M, Lusis AJ. PMID: 19648292; PMCID: PMC2758141.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    41. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res. 2008 Mar 14; 102(5):589-96. Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE. PMID: 18202315; PMCID: PMC3014059.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    42. Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis. Circ Res. 2007 Jun 22; 100(12):1703-11. Orozco LD, Kapturczak MH, Barajas B, Wang X, Weinstein MM, Wong J, Deshane J, Bolisetty S, Shaposhnik Z, Shih DM, Agarwal A, Lusis AJ, Araujo JA. PMID: 17495224.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    43. Viral interleukin-10 gene transfer prevents liver ischemia-reperfusion injury: Toll-like receptor-4 and heme oxygenase-1 signaling in innate and adaptive immunity. Hum Gene Ther. 2007 Apr; 18(4):355-66. Ke B, Shen XD, Tsuchihashi S, Gao F, Araujo JA, Busuttil RW, Ritter T, Kupiec-Weglinski JW. PMID: 17439357.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    44. High-density lipoprotein modulates oxidized phospholipid signaling in human endothelial cells from proinflammatory to anti-inflammatory. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1346-53. Gharavi NM, Gargalovic PS, Chang I, Araujo JA, Clark MJ, Szeto WL, Watson AD, Lusis AJ, Berliner JA. PMID: 17379837.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    45. Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells. Genome Biol. 2007; 8(7):R149. Gong KW, Zhao W, Li N, Barajas B, Kleinman M, Sioutas C, Horvath S, Lusis AJ, Nel A, Araujo JA. PMID: 17655762; PMCID: PMC2323217.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    46. Basal rather than induced heme oxygenase-1 levels are crucial in the antioxidant cytoprotection. J Immunol. 2006 Oct 01; 177(7):4749-57. Tsuchihashi S, Livhits M, Zhai Y, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. PMID: 16982915.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    47. Pericarditis associated with nickel hypersensitivity to the Amplatzer occluder device: a case report. Catheter Cardiovasc Interv. 2005 Nov; 66(3):424-6. Lai DW, Saver JL, Araujo JA, Reidl M, Tobis J. PMID: 16208708.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    48. Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol. 2003 Aug 01; 171(3):1572-80. Araujo JA, Meng L, Tward AD, Hancock WW, Zhai Y, Lee A, Ishikawa K, Iyer S, Buelow R, Busuttil RW, Shih DM, Lusis AJ, Kupiec-Weglinski JW. PMID: 12874251.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
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