Jason Hong

Title(s)HS Assistant Clinical Professor, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0002-5062-8926 Additional info
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    Dr. Jason Hong is a pulmonary and critical care physician who practices in Westwood and provides care to patients admitted to UCLA hospitals in Westwood and Santa Monica. He is board-certified in Internal Medicine, Pulmonary Disease and Critical Care Medicine. His primary clinical interests are in pulmonary vascular diseases such as pulmonary arterial hypertension.

    In addition to his clinical practice, Dr. Hong conducts translational research to uncover the molecular mechanisms of pulmonary arterial hypertension with the ultimate goal of finding more effective therapies for patients. To achieve this goal, he combines experimental investigations using preclinical models and clinical samples with novel computational approaches leveraging advanced sequencing technologies.

    Dr. Hong received his undergraduate and MPH degrees from UC Berkeley and his medical degree from Loma Linda University. He completed an internal medicine residency at Columbia and a pulmonary and critical care fellowship at UCLA. He also received his Ph.D. in Molecular, Cellular, and Integrative Physiology at UCLA.

    Dr. Hong is an assistant clinical professor at the David Geffen School of Medicine at UCLA and a member of the American Thoracic Society.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Digital Spatial Profiling Identifies Distinct Molecular Signatures of Vascular Lesions in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2024 Apr 03. Tuder RM, Gandjeva A, Williams S, Kumar S, Kheyfets VO, Hatton-Jones KM, Starr JR, Yun J, Hong J, West NP, Stenmark KR. PMID: 38568479.
      View in: PubMed   Mentions:    Fields:    
    2. Functions of RNA-Binding Proteins in Cardiovascular Disease. Cells. 2023 12 08; 12(24). Ruffenach G, Medzikovic L, Sun W, Hong J, Eghbali M. PMID: 38132114; PMCID: PMC10742114.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Myocardial fibrosis and calcification are attenuated by microRNA-129-5p targeting Asporin and Sox9 in cardiac fibroblasts. JCI Insight. 2023 05 08; 8(9). Medzikovic L, Aryan L, Ruffenach G, Li M, Savalli N, Sun W, Sarji S, Hong J, Sharma S, Olcese R, Fishbein G, Eghbali M. PMID: 37154157; PMCID: PMC10243800.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    4. Thoracic Spinal Cord Neuroinflammation as a Novel Therapeutic Target in Pulmonary Hypertension. Hypertension. 2023 06; 80(6):1297-1310. Razee A, Banerjee S, Hong J, Magaki S, Fishbein G, Ajijola OA, Umar S. PMID: 37092338; PMCID: PMC10192067.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol. 2023 04; 68(4):381-394. Hong J, Wong B, Huynh C, Tang B, Ruffenach G, Li M, Umar S, Yang X, Eghbali M. PMID: 36252184; PMCID: PMC10112423.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Integrative Multiomics to Dissect the Lung Transcriptional Landscape of Pulmonary Arterial Hypertension. bioRxiv. 2023 Jan 16. Hong J, Wong B, Rhodes CJ, Kurt Z, Schwantes-An TH, Mickler EA, Gräf S, Eyries M, Lutz KA, Pauciulo MW, Trembath RC, Montani D, Morrell NW, Wilkins MR, Nichols WC, Trégouët DA, Aldred MA, Desai AA, Tuder RM, Geraci MW, Eghbali M, Stearman RS, Yang X. PMID: 36712057; PMCID: PMC9882207.
      View in: PubMed   Mentions:
    7. Comparative analysis of right ventricular metabolic reprogramming in pre-clinical rat models of severe pulmonary hypertension-induced right ventricular failure. Front Cardiovasc Med. 2022; 9:935423. Banerjee S, Hong J, Umar S. PMID: 36158812; PMCID: PMC9500217.
      View in: PubMed   Mentions: 1  
    8. Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines. Am J Respir Crit Care Med. 2022 07 15; 206(2):186-196. Cunningham CM, Li M, Ruffenach G, Doshi M, Aryan L, Hong J, Park J, Hrncir H, Medzikovic L, Umar S, Arnold AP, Eghbali M. PMID: 35504005; PMCID: PMC9887415.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    9. Response by Park et al to Letter Regarding Article, "Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure". Circ Heart Fail. 2022 07; 15(7):e008632. Park J, Banerjee S, Hong J, Umar S. PMID: 35766030; PMCID: PMC9348824.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Significance of autoimmune disease in severe pulmonary hypertension complicating extensive pulmonary fibrosis: a prospective cohort study. Pulm Circ. 2021 Apr-Jun; 11(2):20458940211011329. Saggar R, Giri PC, Deng C, Johnson D, McCloy MK, Liang L, Shaikh F, Hong J, Channick RN, Shapiro SS, Lynch JP, Belperio JA, Weigt SS, Ramsey AL, Ross DJ, Sayah DM, Shino MY, Derhovanessian A, Sherman AE, Saggar R. PMID: 33996029; PMCID: PMC8108092.
      View in: PubMed   Mentions: 3  
    11. Single-Cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning. Am J Respir Crit Care Med. 2021 04 15; 203(8):1006-1022. Hong J, Arneson D, Umar S, Ruffenach G, Cunningham CM, Ahn IS, Diamante G, Bhetraratana M, Park JF, Said E, Huynh C, Le T, Medzikovic L, Humbert M, Soubrier F, Montani D, Girerd B, Trégouët DA, Channick R, Saggar R, Eghbali M, Yang X. PMID: 33021809; PMCID: PMC8048757.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    12. Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure. Circ Heart Fail. 2021 02; 14(2):e007058. Park JF, Clark VR, Banerjee S, Hong J, Razee A, Williams T, Fishbein G, Saddic L, Umar S. PMID: 33541093; PMCID: PMC7887079.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    13. Pulmonary hypertension secondary to pulmonary fibrosis: clinical data, histopathology and molecular insights. Respir Res. 2020 Nov 18; 21(1):303. Ruffenach G, Hong J, Vaillancourt M, Medzikovic L, Eghbali M. PMID: 33208169; PMCID: PMC7677848.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    14. Sex differences underlying preexisting cardiovascular disease and cardiovascular injury in COVID-19. J Mol Cell Cardiol. 2020 11; 148:25-33. Medzikovic L, Cunningham CM, Li M, Amjedi M, Hong J, Ruffenach G, Eghbali M. PMID: 32835666; PMCID: PMC7442559.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    15. Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell-Dependent Endothelial Cell Apoptosis. Hypertension. 2020 09; 76(3):985-996. Ruffenach G, O'Connor E, Vaillancourt M, Hong J, Cao N, Sarji S, Moazeni S, Papesh J, Grijalva V, Cunningham CM, Shu L, Chattopadhyay A, Tiwari S, Mercier O, Perros F, Umar S, Yang X, Gomes AV, Fogelman AM, Reddy ST, Eghbali M. PMID: 32713273; PMCID: PMC8008496.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis. Neurobiol Dis. 2020 07; 141:104877. Liu W, Venugopal S, Majid S, Ahn IS, Diamante G, Hong J, Yang X, Chandler SH. PMID: 32360664; PMCID: PMC7519882.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    17. Involvement of Low-Density Lipoprotein Receptor in the Pathogenesis of Pulmonary Hypertension. J Am Heart Assoc. 2020 01 21; 9(2):e012063. Umar S, Ruffenach G, Moazeni S, Vaillancourt M, Hong J, Cunningham C, Cao N, Navab S, Sarji S, Li M, Lee L, Fishbein G, Ardehali A, Navab M, Reddy ST, Eghbali M. PMID: 31914876; PMCID: PMC7033825.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    18. Differential metabolic and multi-tissue transcriptomic responses to fructose consumption among genetically diverse mice. Biochim Biophys Acta Mol Basis Dis. 2020 01 01; 1866(1):165569. Zhang G, Byun HR, Ying Z, Blencowe M, Zhao Y, Hong J, Shu L, Chella Krishnan K, Gomez-Pinilla F, Yang X. PMID: 31669422; PMCID: PMC6993985.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    19. Diesel exhaust particles dysregulate multiple immunological pathways in murine macrophages: Lessons from microarray and scRNA-seq technologies. Arch Biochem Biophys. 2019 12 15; 678:108116. Bhetraratana M, Orozco LD, Hong J, Diamante G, Majid S, Bennett BJ, Ahn IS, Yang X, Lusis AJ, Araujo JA. PMID: 31568751; PMCID: PMC7984963.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis. EMBO Mol Med. 2019 09; 11(9):e10061. Ruffenach G, Umar S, Vaillancourt M, Hong J, Cao N, Sarji S, Moazeni S, Cunningham CM, Ardehali A, Reddy ST, Saggar R, Fishbein G, Eghbali M. PMID: 31468711; PMCID: PMC6728601.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    21. Ampk regulates IgD expression but not energy stress with B cell activation. Sci Rep. 2019 06 03; 9(1):8176. Waters LR, Ahsan FM, Ten Hoeve J, Hong JS, Kim DNH, Minasyan A, Braas D, Graeber TG, Zangle TA, Teitell MA. PMID: 31160601; PMCID: PMC6546716.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    22. Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells. Cell Metab. 2016 05 10; 23(5):921-9. Wu TH, Sagullo E, Case D, Zheng X, Li Y, Hong JS, TeSlaa T, Patananan AN, McCaffery JM, Niazi K, Braas D, Koehler CM, Graeber TG, Chiou PY, Teitell MA. PMID: 27166949; PMCID: PMC5062745.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    23. Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells. Nat Protoc. 2012 May 10; 7(6):1068-85. Zhang J, Nuebel E, Wisidagama DR, Setoguchi K, Hong JS, Van Horn CM, Imam SS, Vergnes L, Malone CS, Koehler CM, Teitell MA. PMID: 22576106; PMCID: PMC3819135.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansCells
    24. Correcting human mitochondrial mutations with targeted RNA import. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4840-5. Wang G, Shimada E, Zhang J, Hong JS, Smith GM, Teitell MA, Koehler CM. PMID: 22411789; PMCID: PMC3323963.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    25. UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J. 2011 Nov 15; 30(24):4860-73. Zhang J, Khvorostov I, Hong JS, Oktay Y, Vergnes L, Nuebel E, Wahjudi PN, Setoguchi K, Wang G, Do A, Jung HJ, McCaffery JM, Kurland IJ, Reue K, Lee WN, Koehler CM, Teitell MA. PMID: 22085932; PMCID: PMC3243621.
      View in: PubMed   Mentions: 257     Fields:    Translation:HumansCells
    26. Rapid, massively parallel single-cell drug response measurements via live cell interferometry. Biophys J. 2011 Sep 07; 101(5):1025-31. Reed J, Chun J, Zangle TA, Kalim S, Hong JS, Pefley SE, Zheng X, Gimzewski JK, Teitell MA. PMID: 21889438; PMCID: PMC3164181.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    27. AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling. Mol Cell. 2010 Sep 24; 39(6):873-85. Sherman MH, Kuraishy AI, Deshpande C, Hong JS, Cacalano NA, Gatti RA, Manis JP, Damore MA, Pellegrini M, Teitell MA. PMID: 20864035; PMCID: PMC2945612.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    28. PNPASE regulates RNA import into mitochondria. Cell. 2010 Aug 06; 142(3):456-67. Wang G, Chen HW, Oktay Y, Zhang J, Allen EL, Smith GM, Fan KC, Hong JS, French SW, McCaffery JM, Lightowlers RN, Morse HC, Koehler CM, Teitell MA. PMID: 20691904; PMCID: PMC2921675.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansAnimalsCells
    29. Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission. PLoS One. 2010 Apr 20; 5(4):e10213. Heath L, Conway S, Jones L, Semrau K, Nakamura K, Walter J, Decker WD, Hong J, Chen T, Heil M, Sinkala M, Kankasa C, Thea DM, Kuhn L, Mullins JI, Aldrovandi GM. PMID: 20422033; PMCID: PMC2857876.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    30. Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood. 2009 Mar 12; 113(11):2478-87. Frank MJ, Dawson DW, Bensinger SJ, Hong JS, Knosp WM, Xu L, Balatoni CE, Allen EL, Shen RR, Bar-Sagi D, Martin GR, Teitell MA. PMID: 19147787; PMCID: PMC2656273.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
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