Steven J Bensinger

Title(s)Department Vice Chair, MIMG
SchoolMedicine
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    Title(s)Professor, MIMG

    Title(s)Professor, Molecular and Medical Pharmacology


    Collapse Biography 
    Collapse Education and Training
    University of Pennsylvania School of Veterinary Medicine, Philadelphia, PAVMDVeterinary Medicine
    University of Pennsylvania School of Medicine, Philadelphia, PAPhDImmunology

    Collapse Overview 
    Collapse Overview
    The Bensinger Laboratory is in the Department of Microbiology, Immunology, and Molecular Genetics at the University of California, Los Angeles. We apply cutting-edge techniques to understand how lipid metabolism influences cell fate and function. Our work aims to find new ways to extend health and treat human diseases.
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    Collapse Research 
    Collapse Research Activities and Funding
    CDKN2A couples lipid metabolism to ferroptosis in glioblastoma
    NIH R01NS121319Apr 1, 2021 - Jan 31, 2026
    Role: Co-Principal Investigator
    The impact of ERalpha on mitochondrial function in macrophages
    NIH R01DK128957Apr 1, 2021 - Mar 31, 2025
    Role: Co-Investigator
    Investigating the impact of a fatty acid-cRel inflammatory circuit in atherosclerosis
    NIH R01HL157710Apr 1, 2021 - Mar 31, 2025
    Role: Principal Investigator
    New approaches for understanding lipid movement in health and disease
    NIH P01HL146358May 1, 2019 - Apr 30, 2024
    Role: Co-Investigator
    Understanding the influence of SREBP signaling on CD4 T helper cell biology
    NIH R01AI122282Nov 10, 2015 - Oct 31, 2020
    Role: Principal Investigator
    Investigating the crosstalk between lipid metabolism and HIV
    NIH R21HL126556Sep 17, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Determining the Impact of SREBP on Adaptive Immunity
    NIH R01AI093768Apr 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Apoptosis in the Generation of T-cell Memory
    NIH K01RR021975Sep 30, 2005 - Jun 30, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Flow-mediated modulation of the endothelial cell lipidome. Front Physiol. 2024; 15:1431847. Hong SG, Kennelly JP, Williams KJ, Bensinger SJ, Mack JJ. PMID: 39119214; PMCID: PMC11307263.
      View in: PubMed   Mentions:
    2. Flow-Mediated Modulation of the Endothelial Cell Lipidome. bioRxiv. 2024 Jun 15. Hong SG, Kennelly JP, Williams KJ, Bensinger SJ, Mack JJ. PMID: 38915541; PMCID: PMC11195170.
      View in: PubMed   Mentions:
    3. IL-4 Licenses B Cell Activation Through Cholesterol Synthesis. bioRxiv. 2024 May 15. Steach HR, York AG, Skadow MH, Chen S, Zhao J, Williams KJ, Zhou Q, Hsieh WY, Brewer JR, Qu R, Shyer JA, Harman C, Sefik E, Mowell WK, Bailis W, Cui C, Kluger Y, Bensinger SJ, Craft J, Flavell RA. PMID: 38798553; PMCID: PMC11118339.
      View in: PubMed   Mentions:
    4. Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respiration. bioRxiv. 2024 May 14. Ball AB, Jones AE, Nguy?n KB, Rios A, Marx N, Hsieh WY, Yang K, Desousa BR, Kim KKO, Veliova M, Del Mundo ZM, Shirihai OS, Benincá C, Stiles L, Bensinger SJ, Divakaruni AS. PMID: 38798678; PMCID: PMC11118427.
      View in: PubMed   Mentions:
    5. Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models. bioRxiv. 2024 May 09. Sammarco A, Guerra G, Eyme KM, Kennewick K, Qiao Y, Hokayem JE, Williams KJ, Su B, Zappulli V, Bensinger SJ, Badr CE. PMID: 38766019; PMCID: PMC11100738.
      View in: PubMed   Mentions:
    6. The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling. bioRxiv. 2024 Mar 31. Jones AE, Rios A, Ibrahimovic N, Chavez C, Bayley NA, Ball AB, Hsieh WY, Sammarco A, Bianchi AR, Cortez AA, Graeber TG, Hoffmann A, Bensinger SJ, Divakaruni AS. PMID: 38585887; PMCID: PMC10996702.
      View in: PubMed   Mentions:
    7. T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption. bioRxiv. 2024 Mar 11. Gao Y, Kennelly JP, Xiao X, Whang E, Ferrari A, Bedard AH, Mack JJ, Nguyen AH, Weston T, Uchiyama LF, Lee MS, Young SG, Bensinger SJ, Tontonoz P. PMID: 38559079; PMCID: PMC10979874.
      View in: PubMed   Mentions:
    8. IL-10 constrains sphingolipid metabolism to limit inflammation. Nature. 2024 Mar; 627(8004):628-635. York AG, Skadow MH, Oh J, Qu R, Zhou QD, Hsieh WY, Mowel WK, Brewer JR, Kaffe E, Williams KJ, Kluger Y, Smale ST, Crawford JM, Bensinger SJ, Flavell RA. PMID: 38383790; PMCID: PMC10954550.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    9. Metabolic programs of T cell tissue residency empower tumour immunity. Nature. 2023 Sep; 621(7977):179-187. Reina-Campos M, Heeg M, Kennewick K, Mathews IT, Galletti G, Luna V, Nguyen Q, Huang H, Milner JJ, Hu KH, Vichaidit A, Santillano N, Boland BS, Chang JT, Jain M, Sharma S, Krummel MF, Chi H, Bensinger SJ, Goldrath AW. PMID: 37648857; PMCID: PMC11238873.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    10. Commensal Cutibacterium acnes induce epidermal lipid synthesis important for skin barrier function. Sci Adv. 2023 08 18; 9(33):eadg6262. Almoughrabie S, Cau L, Cavagnero K, O'Neill AM, Li F, Roso-Mares A, Mainzer C, Closs B, Kolar MJ, Williams KJ, Bensinger SJ, Gallo RL. PMID: 37595033; PMCID: PMC10438445.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. Calculation of ATP production rates using the Seahorse XF Analyzer. EMBO Rep. 2023 10 09; 24(10):e56380. Desousa BR, Kim KK, Jones AE, Ball AB, Hsieh WY, Swain P, Morrow DH, Brownstein AJ, Ferrick DA, Shirihai OS, Neilson A, Nathanson DA, Rogers GW, Dranka BP, Murphy AN, Affourtit C, Bensinger SJ, Stiles L, Romero N, Divakaruni AS. PMID: 37548091; PMCID: PMC10561364.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    12. CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis. Cancer Cell. 2023 06 12; 41(6):1048-1060.e9. Minami JK, Morrow D, Bayley NA, Fernandez EG, Salinas JJ, Tse C, Zhu H, Su B, Plawat R, Jones A, Sammarco A, Liau LM, Graeber TG, Williams KJ, Cloughesy TF, Dixon SJ, Bensinger SJ, Nathanson DA. PMID: 37236196; PMCID: PMC10330677.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    13. IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation. bioRxiv. 2023 May 08. York AG, Skadow MH, Qu R, Oh J, Mowel WK, Brewer JR, Kaffe E, Williams KJ, Kluger Y, Crawford JM, Smale ST, Bensinger SJ, Flavell RA. PMID: 37214856; PMCID: PMC10197576.
      View in: PubMed   Mentions:
    14. Decoding the crosstalk between mevalonate metabolism and T cell function. Immunol Rev. 2023 08; 317(1):71-94. Kennewick KT, Bensinger SJ. PMID: 36999733.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models. Sci Transl Med. 2023 01 18; 15(679):eabq6288. Eyme KM, Sammarco A, Jha R, Mnatsakanyan H, Pechdimaljian C, Carvalho L, Neustadt R, Moses C, Alnasser A, Tardiff DF, Su B, Williams KJ, Bensinger SJ, Chung CY, Badr CE. PMID: 36652537; PMCID: PMC9942236.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    16. Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis. Nat Metab. 2023 01; 5(1):165-181. Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. PMID: 36646756; PMCID: PMC9995220.
      View in: PubMed   Mentions: 8     Fields:    
    17. Context-dependent regulation of ferroptosis sensitivity. Cell Chem Biol. 2022 Oct 20; 29(10):1568. Magtanong L, Mueller GD, Williams KJ, Billmann M, Chan K, Armenta DA, Pope LE, Moffat J, Boone C, Myers CL, Olzmann JA, Bensinger SJ, Dixon SJ. PMID: 36270234.
      View in: PubMed   Mentions: 7     Fields:    
    18. Context-dependent regulation of ferroptosis sensitivity. Cell Chem Biol. 2022 09 15; 29(9):1409-1418.e6. Magtanong L, Mueller GD, Williams KJ, Billmann M, Chan K, Armenta DA, Pope LE, Moffat J, Boone C, Myers CL, Olzmann JA, Bensinger SJ, Dixon SJ. PMID: 35809566; PMCID: PMC9481678.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    19. Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair. J Clin Invest. 2022 01 18; 132(2). Li S, Yokota T, Wang P, Ten Hoeve J, Ma F, Le TM, Abt ER, Zhou Y, Wu R, Nanthavongdouangsy M, Rodriguez A, Wang Y, Lin YJ, Muranaka H, Sharpley M, Braddock DT, MacRae VE, Banerjee U, Chiou PY, Seldin M, Huang D, Teitell M, Gertsman I, Jung M, Bensinger SJ, Damoiseaux R, Faull K, Pellegrini M, Lusis AJ, Graeber TG, Radu CG, Deb A. PMID: 34813507; PMCID: PMC8759793.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    20. Reprogramming cholesterol metabolism in macrophages and its role in host defense against cholesterol-dependent cytolysins. Cell Mol Immunol. 2022 03; 19(3):327-336. Lee MS, Bensinger SJ. PMID: 35017717; PMCID: PMC8891295.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    21. Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma. Nat Commun. 2021 11 26; 12(1):6938. Lee AH, Sun L, Mochizuki AY, Reynoso JG, Orpilla J, Chow F, Kienzler JC, Everson RG, Nathanson DA, Bensinger SJ, Liau LM, Cloughesy T, Hugo W, Prins RM. PMID: 34836966; PMCID: PMC8626557.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    22. A DMS Shotgun Lipidomics Workflow Application to Facilitate High-Throughput, Comprehensive Lipidomics. J Am Soc Mass Spectrom. 2021 Nov 03; 32(11):2655-2663. Su B, Bettcher LF, Hsieh WY, Hornburg D, Pearson MJ, Blomberg N, Giera M, Snyder MP, Raftery D, Bensinger SJ, Williams KJ. PMID: 34637296; PMCID: PMC8985811.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    23. Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico. Lipids Health Dis. 2021 Oct 10; 20(1):136. Flores YN, Amoon AT, Su B, Velazquez-Cruz R, Ramírez-Palacios P, Salmerón J, Rivera-Paredez B, Sinsheimer JS, Lusis AJ, Huertas-Vazquez A, Saab S, Glenn BA, May FP, Williams KJ, Bastani R, Bensinger SJ. PMID: 34629052; PMCID: PMC8504048.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. Dopamine Receptor Antagonists, Radiation, and Cholesterol Biosynthesis in Mouse Models of Glioblastoma. J Natl Cancer Inst. 2021 08 02; 113(8):1094-1104. Bhat K, Saki M, Cheng F, He L, Zhang L, Ioannidis A, Nathanson D, Tsang J, Bensinger SJ, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. PMID: 33556960; PMCID: PMC8328983.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. Dysregulation of mannose-6-phosphate-dependent cholesterol homeostasis in acinar cells mediates pancreatitis. J Clin Invest. 2021 08 02; 131(15). Mareninova OA, Vegh ET, Shalbueva N, Wightman CJ, Dillon DL, Malla S, Xie Y, Takahashi T, Rakonczay Z, French SW, Gaisano HY, Gorelick FS, Pandol SJ, Bensinger SJ, Davidson NO, Dawson DW, Gukovsky I, Gukovskaya AS. PMID: 34128834; PMCID: PMC8321573.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    26. Profiling of mouse macrophage lipidome using direct infusion shotgun mass spectrometry. STAR Protoc. 2021 03 19; 2(1):100235. Hsieh WY, Williams KJ, Su B, Bensinger SJ. PMID: 33364623; PMCID: PMC7753944.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    27. Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome. Cell Metab. 2020 07 07; 32(1):128-143.e5. Hsieh WY, Zhou QD, York AG, Williams KJ, Scumpia PO, Kronenberger EB, Hoi XP, Su B, Chi X, Bui VL, Khialeeva E, Kaplan A, Son YM, Divakaruni AS, Sun J, Smale ST, Flavell RA, Bensinger SJ. PMID: 32516576; PMCID: PMC7891175.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    28. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nat Immunol. 2020 07; 21(7):746-755. Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. PMID: 32514064; PMCID: PMC7778040.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    29. (Sterol)ized Immunity: Could PI3K/AKT3 Be the Answer? Immunity. 2020 01 14; 52(1):4-6. Chi X, Bensinger SJ. PMID: 31951549.
      View in: PubMed   Mentions: 4     Fields:    
    30. Cellular Fatty Acid Analysis in Macrophage Using Stable Isotope Labeling. Methods Mol Biol. 2020; 2184:47-60. Williams KJ, Bensinger SJ. PMID: 32808217.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    31. Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling. Cell Rep. 2018 12 04; 25(10):2919-2934.e8. Argus JP, Wilks MQ, Zhou QD, Hsieh WY, Khialeeva E, Hoi XP, Bui V, Xu S, Yu AK, Wang ES, Herschman HR, Williams KJ, Bensinger SJ. PMID: 30517876; PMCID: PMC6432944.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    32. Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice. Arterioscler Thromb Vasc Biol. 2018 09; 38(9):2016-2027. Erbilgin A, Seldin MM, Wu X, Mehrabian M, Zhou Z, Qi H, Dabirian KS, Sevag Packard RR, Hsieh W, Bensinger SJ, Sinha S, Lusis AJ. PMID: 30026271; PMCID: PMC6202168.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    33. Macrophages release plasma membrane-derived particles rich in accessible cholesterol. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8499-E8508. He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG. PMID: 30127022; PMCID: PMC6130402.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    34. Maintenance of CD4 T cell fitness through regulation of Foxo1. Nat Immunol. 2018 08; 19(8):838-848. Newton RH, Shrestha S, Sullivan JM, Yates KB, Compeer EB, Ron-Harel N, Blazar BR, Bensinger SJ, Haining WN, Dustin ML, Campbell DJ, Chi H, Turka LA. PMID: 29988091; PMCID: PMC6289177.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    35. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab. 2018 09 04; 28(3):504-515.e7. Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L. PMID: 30043753; PMCID: PMC6747686.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    36. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab. 2018 09 04; 28(3):490-503.e7. Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN. PMID: 30043752; PMCID: PMC6125190.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    37. Mechanobiological Mimicry of Helper T Lymphocytes to Evaluate Cell-Biomaterials Crosstalk. Adv Mater. 2018 Jun; 30(23):e1706780. Hasani-Sadrabadi MM, Majedi FS, Bensinger SJ, Wu BM, Bouchard LS, Weiss PS, Moshaverinia A. PMID: 29682803.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    38. Cytokine Secreting Microparticles Engineer the Fate and the Effector Functions of T-Cells. Adv Mater. 2018 Feb; 30(7). Majedi FS, Hasani-Sadrabadi MM, Kidani Y, Thauland TJ, Moshaverinia A, Butte MJ, Bensinger SJ, Bouchard LS. PMID: 29315824; PMCID: PMC5854475.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    39. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017 Nov; 23(11):1342-1351. Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA. PMID: 29035366; PMCID: PMC5683421.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    40. Reviewing the impact of lipid synthetic flux on Th17 function. Curr Opin Immunol. 2017 Jun; 46:121-126. Kidani Y, Bensinger SJ. PMID: 28668661.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    41. Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum. J Lipid Res. 2017 08; 58(8):1636-1647. Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis AJ, Iruela-Arispe ML, Bostrom KI, Tontonoz P, Reddy ST, Fogelman AM. PMID: 28592401; PMCID: PMC5538285.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    42. Bruton Tyrosine Kinase Inhibition Attenuates Liver Damage in a Mouse Warm Ischemia and Reperfusion Model. Transplantation. 2017 02; 101(2):322-331. Palumbo T, Nakamura K, Lassman C, Kidani Y, Bensinger SJ, Busuttil R, Kupiec-Weglinski J, Zarrinpar A. PMID: 27820779; PMCID: PMC5263143.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    43. Reelin Deficiency Delays Mammary Tumor Growth and Metastatic Progression. J Mammary Gland Biol Neoplasia. 2017 03; 22(1):59-69. Khialeeva E, Chou JW, Allen DE, Chiu AM, Bensinger SJ, Carpenter EM. PMID: 28124184; PMCID: PMC5319436.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    44. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. 2016 12 20; 45(6):1311-1326. Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P. PMID: 28002731; PMCID: PMC5181791.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    45. An optimized method for measuring fatty acids and cholesterol in stable isotope-labeled cells. J Lipid Res. 2017 02; 58(2):460-468. Argus JP, Yu AK, Wang ES, Williams KJ, Bensinger SJ. PMID: 27974366; PMCID: PMC5282944.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    46. Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division. J Biol Chem. 2016 08 12; 291(33):17001-8. Gholkar AA, Cheung K, Williams KJ, Lo YC, Hamideh SA, Nnebe C, Khuu C, Bensinger SJ, Torres JZ. PMID: 27378817; PMCID: PMC5016105.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    47. Modulating Cholesterol Homeostasis to Build a Better T Cell. Cell Metab. 2016 06 14; 23(6):963-964. Kidani Y, Bensinger SJ. PMID: 27304495.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    48. Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux. J Lipid Res. 2016 07; 57(7):1175-93. Meriwether D, Sulaiman D, Wagner A, Grijalva V, Kaji I, Williams KJ, Yu L, Fogelman S, Volpe C, Bensinger SJ, Anantharamaiah GM, Shechter I, Fogelman AM, Reddy ST. PMID: 27199144; PMCID: PMC4918848.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    49. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628; PMCID: PMC4934679.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    50. Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence. PLoS Pathog. 2016 Jan; 12(1):e1005356. Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale ST, Brooks DG. PMID: 26808628; PMCID: PMC4726812.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    51. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell. 2015 Dec 17; 163(7):1716-29. York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. PMID: 26686653; PMCID: PMC4783382.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansAnimalsCells
    52. Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis. PLoS One. 2015; 10(6):e0129776. Mercer JL, Argus JP, Crabtree DM, Keenan MM, Wilks MQ, Chi JT, Bensinger SJ, Lavau CP, Wechsler DS. PMID: 26075887; PMCID: PMC4467867.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    53. Resveratrol and para-coumarate serve as ring precursors for coenzyme Q biosynthesis. J Lipid Res. 2015 Apr; 56(4):909-19. Xie LX, Williams KJ, He CH, Weng E, Khong S, Rose TE, Kwon O, Bensinger SJ, Marbois BN, Clarke CF. PMID: 25681964; PMCID: PMC4373747.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    54. Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus. J Clin Invest. 2014 Feb; 124(2):482-5. Kidani Y, Bensinger SJ. PMID: 24463443; PMCID: PMC3904634.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    55. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct; 14(10):1073-83. Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. PMID: 24013668; PMCID: PMC3800053.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    56. Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth. J Exp Med. 2013 Aug 26; 210(9):1653-6. York AG, Bensinger SJ. PMID: 23980123; PMCID: PMC3754867.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    57. Immunology. Fueling function over expansion in T cells. Science. 2013 Jul 05; 341(6141):37-8. Argus JP, Bensinger SJ. PMID: 23828930.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    58. Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013; 8(5):e64561. Ahler E, Sullivan WJ, Cass A, Braas D, York AG, Bensinger SJ, Graeber TG, Christofk HR. PMID: 23741339; PMCID: PMC3669316.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    59. Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol. 2013 May; 14(5):489-99. Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ. PMID: 23563690; PMCID: PMC3652626.
      View in: PubMed   Mentions: 268     Fields:    Translation:AnimalsCells
    60. De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discov. 2013 May; 3(5):534-47. Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS. PMID: 23533263; PMCID: PMC3651754.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    61. An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res. 2013 May 01; 73(9):2850-62. Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. PMID: 23440422; PMCID: PMC3919498.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    62. Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity. Immunol Rev. 2012 Sep; 249(1):72-83. Kidani Y, Bensinger SJ. PMID: 22889216; PMCID: PMC4007066.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    63. Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection. Cell Host Microbe. 2012 May 17; 11(5):481-91. Wilson EB, Kidani Y, Elsaesser H, Barnard J, Raff L, Karp CL, Bensinger S, Brooks DG. PMID: 22607801; PMCID: PMC3359873.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    64. New aspects of the Warburg effect in cancer cell biology. Semin Cell Dev Biol. 2012 Jun; 23(4):352-61. Bensinger SJ, Christofk HR. PMID: 22406683.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    65. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest. 2012 Jan; 122(1):337-47. Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. PMID: 22156197; PMCID: PMC3248291.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    66. Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16457-62. Ribas V, Drew BG, Le JA, Soleymani T, Daraei P, Sitz D, Mohammad L, Henstridge DC, Febbraio MA, Hewitt SC, Korach KS, Bensinger SJ, Hevener AL. PMID: 21900603; PMCID: PMC3182726.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    67. Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death. Immunol Lett. 2011 Sep 30; 139(1-2):25-32. Wolkers MC, Bensinger SJ, Green DR, Schoenberger SP, Janssen EM. PMID: 21621553; PMCID: PMC3146632.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    68. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology. 2011 Mar; 140(3):1052-62. Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. PMID: 21134374; PMCID: PMC3049833.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    69. EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy. Sci Signal. 2009 Dec 15; 2(101):ra82. Guo D, Prins RM, Dang J, Kuga D, Iwanami A, Soto H, Lin KY, Huang TT, Akhavan D, Hock MB, Zhu S, Kofman AA, Bensinger SJ, Yong WH, Vinters HV, Horvath S, Watson AD, Kuhn JG, Robins HI, Mehta MP, Wen PY, DeAngelis LM, Prados MD, Mellinghoff IK, Cloughesy TF, Mischel PS. PMID: 20009104; PMCID: PMC2978002.
      View in: PubMed   Mentions: 197     Fields:    Translation:HumansCells
    70. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 2009 Aug 21; 31(2):245-58. A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, Díaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, Andujar M, Tontonoz P, Castrillo A. PMID: 19646905; PMCID: PMC2791787.
      View in: PubMed   Mentions: 347     Fields:    Translation:AnimalsCells
    71. A Nurr1 pathway for neuroprotection. Cell. 2009 Apr 03; 137(1):26-8. Bensinger SJ, Tontonoz P. PMID: 19345183.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    72. Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood. 2009 Mar 12; 113(11):2478-87. Frank MJ, Dawson DW, Bensinger SJ, Hong JS, Knosp WM, Xu L, Balatoni CE, Allen EL, Shen RR, Bar-Sagi D, Martin GR, Teitell MA. PMID: 19147787; PMCID: PMC2656273.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    73. Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Mol Endocrinol. 2008 Dec; 22(12):2596-608. Chao LC, Bensinger SJ, Villanueva CJ, Wroblewski K, Tontonoz P. PMID: 18945812; PMCID: PMC2610364.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    74. HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation. J Lipid Res. 2008 Dec; 49(12):2535-44. Hummasti S, Hong C, Bensinger SJ, Tontonoz P. PMID: 18664718; PMCID: PMC2582369.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    75. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature. 2008 Jul 24; 454(7203):470-7. Bensinger SJ, Tontonoz P. PMID: 18650918.
      View in: PubMed   Mentions: 357     Fields:    Translation:HumansAnimalsCells
    76. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 2008 Jul 11; 134(1):97-111. Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P. PMID: 18614014; PMCID: PMC2626438.
      View in: PubMed   Mentions: 348     Fields:    Translation:HumansAnimalsCells
    77. PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest. 2006 Sep; 116(9):2521-31. Walsh PT, Buckler JL, Zhang J, Gelman AE, Dalton NM, Taylor DK, Bensinger SJ, Hancock WW, Turka LA. PMID: 16917540; PMCID: PMC1550279.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    78. Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature. 2006 Apr 20; 440(7087):1064-8. Saleh M, Mathison JC, Wolinski MK, Bensinger SJ, Fitzgerald P, Droin N, Ulevitch RJ, Green DR, Nicholson DW. PMID: 16625199.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    79. Developmental alterations in thymocyte sensitivity are actively regulated by MHC class II expression in the thymic medulla. J Immunol. 2006 Feb 15; 176(4):2229-37. Eck SC, Zhu P, Pepper M, Bensinger SJ, Freedman BD, Laufer TM. PMID: 16455979.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    80. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature. 2005 Mar 03; 434(7029):88-93. Janssen EM, Droin NM, Lemmens EE, Pinkoski MJ, Bensinger SJ, Ehst BD, Griffith TS, Green DR, Schoenberger SP. PMID: 15744305.
      View in: PubMed   Mentions: 266     Fields:    Translation:AnimalsCells
    81. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol. 2004 Oct; 24(20):9038-47. Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH. PMID: 15456877; PMCID: PMC517905.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    82. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol. 2004 May 01; 172(9):5287-96. Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, Thompson CB, Burchill MA, Farrar MA, Turka LA. PMID: 15100267; PMCID: PMC2842445.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    83. Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol. 2003 Dec 01; 171(11):5853-64. Burchill MA, Goetz CA, Prlic M, O'Neil JJ, Harmon IR, Bensinger SJ, Turka LA, Brennan P, Jameson SC, Farrar MA. PMID: 14634095.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    84. Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med. 2004 Jan; 10(1):87-92. Wu Z, Bensinger SJ, Zhang J, Chen C, Yuan X, Huang X, Markmann JF, Kassaee A, Rosengard BR, Hancock WW, Sayegh MH, Turka LA. PMID: 14647496; PMCID: PMC2839903.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    85. Stemming the tide of rejection. Nat Med. 2002 Feb; 8(2):107-8. Adler SH, Bensinger SJ, Turka LA. PMID: 11821887.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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