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Steven J Bensinger

Title(s)Professor, MIMG
SchoolMedicine
Address760 Westwood Plaza 23-120
Los Angeles CA 90024
Phone59885
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    Other Positions
    Title(s)Professor, Molecular and Medical Pharmacology


    Collapse Research 
    Collapse Research Activities and Funding
    Understanding the influence of SREBP signaling on CD4 T helper cell biology
    NIH/NIAID R01AI122282Nov 10, 2015 - Oct 31, 2020
    Role: Principal Investigator
    Investigating the crosstalk between lipid metabolism and HIV
    NIH/NHLBI R21HL126556Sep 17, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Determining the Impact of SREBP on Adaptive Immunity
    NIH/NIAID R01AI093768Apr 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Apoptosis in the Generation of T-cell Memory
    NIH/NCRR K01RR021975Sep 30, 2005 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome. Cell Metab. 2020 Jul 07; 32(1):128-143.e5. Hsieh WY, Zhou QD, York AG, Williams KJ, Scumpia PO, Kronenberger EB, Hoi XP, Su B, Chi X, Bui VL, Khialeeva E, Kaplan A, Son YM, Divakaruni AS, Sun J, Smale ST, Flavell RA, Bensinger SJ. PMID: 32516576.
      View in: PubMed   Mentions:    Fields:    
    2. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nat Immunol. 2020 Jul; 21(7):746-755. Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. PMID: 32514064.
      View in: PubMed   Mentions:    Fields:    
    3. (Sterol)ized Immunity: Could PI3K/AKT3 Be the Answer? Immunity. 2020 01 14; 52(1):4-6. Chi X, Bensinger SJ. PMID: 31951549.
      View in: PubMed   Mentions:    Fields:    
    4. Cellular Fatty Acid Analysis in Macrophage Using Stable Isotope Labeling. Methods Mol Biol. 2020; 2184:47-60. Williams KJ, Bensinger SJ. PMID: 32808217.
      View in: PubMed   Mentions:    Fields:    
    5. Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling. Cell Rep. 2018 12 04; 25(10):2919-2934.e8. Argus JP, Wilks MQ, Zhou QD, Hsieh WY, Khialeeva E, Hoi XP, Bui V, Xu S, Yu AK, Wang ES, Herschman HR, Williams KJ, Bensinger SJ. PMID: 30517876.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice. Arterioscler Thromb Vasc Biol. 2018 09; 38(9):2016-2027. Erbilgin A, Seldin MM, Wu X, Mehrabian M, Zhou Z, Qi H, Dabirian KS, Sevag Packard RR, Hsieh W, Bensinger SJ, Sinha S, Lusis AJ. PMID: 30026271.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Macrophages release plasma membrane-derived particles rich in accessible cholesterol. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8499-E8508. He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG. PMID: 30127022.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab. 2018 09 04; 28(3):490-503.e7. Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN. PMID: 30043752.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    9. Mechanobiological Mimicry of Helper T Lymphocytes to Evaluate Cell-Biomaterials Crosstalk. Adv Mater. 2018 Jun; 30(23):e1706780. Hasani-Sadrabadi MM, Majedi FS, Bensinger SJ, Wu BM, Bouchard LS, Weiss PS, Moshaverinia A. PMID: 29682803.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    10. Cytokine Secreting Microparticles Engineer the Fate and the Effector Functions of T-Cells. Adv Mater. 2018 Feb; 30(7). Majedi FS, Hasani-Sadrabadi MM, Kidani Y, Thauland TJ, Moshaverinia A, Butte MJ, Bensinger SJ, Bouchard LS. PMID: 29315824.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    11. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017 Nov; 23(11):1342-1351. Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA. PMID: 29035366.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    12. Reviewing the impact of lipid synthetic flux on Th17 function. Curr Opin Immunol. 2017 Jun; 46:121-126. Kidani Y, Bensinger SJ. PMID: 28668661.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-ß and cholesterol 25-hydroxylase in jejunum. J Lipid Res. 2017 08; 58(8):1636-1647. Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis AJ, Iruela-Arispe ML, Bostrom KI, Tontonoz P, Reddy ST, Fogelman AM. PMID: 28592401.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    14. Bruton Tyrosine Kinase Inhibition Attenuates Liver Damage in a Mouse Warm Ischemia and Reperfusion Model. Transplantation. 2017 02; 101(2):322-331. Palumbo T, Nakamura K, Lassman C, Kidani Y, Bensinger SJ, Busuttil R, Kupiec-Weglinski J, Zarrinpar A. PMID: 27820779.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Reelin Deficiency Delays Mammary Tumor Growth and Metastatic Progression. J Mammary Gland Biol Neoplasia. 2017 03; 22(1):59-69. Khialeeva E, Chou JW, Allen DE, Chiu AM, Bensinger SJ, Carpenter EM. PMID: 28124184.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. 2016 12 20; 45(6):1311-1326. Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P. PMID: 28002731.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    17. An optimized method for measuring fatty acids and cholesterol in stable isotope-labeled cells. J Lipid Res. 2017 02; 58(2):460-468. Argus JP, Yu AK, Wang ES, Williams KJ, Bensinger SJ. PMID: 27974366.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. Modulating Cholesterol Homeostasis to Build a Better T Cell. Cell Metab. 2016 06 14; 23(6):963-964. Kidani Y, Bensinger SJ. PMID: 27304495.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    19. Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux. J Lipid Res. 2016 07; 57(7):1175-93. Meriwether D, Sulaiman D, Wagner A, Grijalva V, Kaji I, Williams KJ, Yu L, Fogelman S, Volpe C, Bensinger SJ, Anantharamaiah GM, Shechter I, Fogelman AM, Reddy ST. PMID: 27199144.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. Skeletal muscle action of estrogen receptor a is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    21. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell. 2015 Dec 17; 163(7):1716-29. York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. PMID: 26686653.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    22. Resveratrol and para-coumarate serve as ring precursors for coenzyme Q biosynthesis. J Lipid Res. 2015 Apr; 56(4):909-19. Xie LX, Williams KJ, He CH, Weng E, Khong S, Rose TE, Kwon O, Bensinger SJ, Marbois BN, Clarke CF. PMID: 25681964.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    23. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct; 14(10):1073-83. Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. PMID: 24013668.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    24. Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth. J Exp Med. 2013 Aug 26; 210(9):1653-6. York AG, Bensinger SJ. PMID: 23980123.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. Immunology. Fueling function over expansion in T cells. Science. 2013 Jul 05; 341(6141):37-8. Argus JP, Bensinger SJ. PMID: 23828930.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    26. Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013; 8(5):e64561. Ahler E, Sullivan WJ, Cass A, Braas D, York AG, Bensinger SJ, Graeber TG, Christofk HR. PMID: 23741339.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    27. Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol. 2013 May; 14(5):489-99. Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ. PMID: 23563690.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    28. De-repression of PDGFRß transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discov. 2013 May; 3(5):534-47. Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS. PMID: 23533263.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    29. An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res. 2013 May 01; 73(9):2850-62. Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. PMID: 23440422.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    30. Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity. Immunol Rev. 2012 Sep; 249(1):72-83. Kidani Y, Bensinger SJ. PMID: 22889216.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    31. Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection. Cell Host Microbe. 2012 May 17; 11(5):481-91. Wilson EB, Kidani Y, Elsaesser H, Barnard J, Raff L, Karp CL, Bensinger S, Brooks DG. PMID: 22607801.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    32. New aspects of the Warburg effect in cancer cell biology. Semin Cell Dev Biol. 2012 Jun; 23(4):352-61. Bensinger SJ, Christofk HR. PMID: 22406683.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    33. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest. 2012 Jan; 122(1):337-47. Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. PMID: 22156197.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    34. Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16457-62. Ribas V, Drew BG, Le JA, Soleymani T, Daraei P, Sitz D, Mohammad L, Henstridge DC, Febbraio MA, Hewitt SC, Korach KS, Bensinger SJ, Hevener AL. PMID: 21900603.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    35. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology. 2011 Mar; 140(3):1052-62. Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. PMID: 21134374.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    36. EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy. Sci Signal. 2009 Dec 15; 2(101):ra82. Guo D, Prins RM, Dang J, Kuga D, Iwanami A, Soto H, Lin KY, Huang TT, Akhavan D, Hock MB, Zhu S, Kofman AA, Bensinger SJ, Yong WH, Vinters HV, Horvath S, Watson AD, Kuhn JG, Robins HI, Mehta MP, Wen PY, DeAngelis LM, Prados MD, Mellinghoff IK, Cloughesy TF, Mischel PS. PMID: 20009104.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    37. A Nurr1 pathway for neuroprotection. Cell. 2009 Apr 03; 137(1):26-8. Bensinger SJ, Tontonoz P. PMID: 19345183.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    38. Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood. 2009 Mar 12; 113(11):2478-87. Frank MJ, Dawson DW, Bensinger SJ, Hong JS, Knosp WM, Xu L, Balatoni CE, Allen EL, Shen RR, Bar-Sagi D, Martin GR, Teitell MA. PMID: 19147787.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    39. Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Mol Endocrinol. 2008 Dec; 22(12):2596-608. Chao LC, Bensinger SJ, Villanueva CJ, Wroblewski K, Tontonoz P. PMID: 18945812.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    40. HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation. J Lipid Res. 2008 Dec; 49(12):2535-44. Hummasti S, Hong C, Bensinger SJ, Tontonoz P. PMID: 18664718.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    41. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature. 2008 Jul 24; 454(7203):470-7. Bensinger SJ, Tontonoz P. PMID: 18650918.
      View in: PubMed   Mentions: 242     Fields:    Translation:HumansAnimalsCells
    42. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 2008 Jul 11; 134(1):97-111. Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P. PMID: 18614014.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimalsCells
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