Claudio Javier Villanueva
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| Title(s) | Associate Professor, Integrative Biology And Physiology |
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| School | College of Letters and Science |
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| vCard | Download vCard |
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Biography
| UCSF, San Francisco | PhD | 06/2007 | Biomedical Sciences |
| CSUSB, San Bernardino | BA | 06/2001 | Biology |
| UCLA , Los Angeles | Postdoc | 07/2012 | Gene Regulation |
Overview
Research
Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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PPARγ-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity. Cell Rep. 2024 Dec 24; 43(12):114945.
De Siqueira MK, Li G, Zhao Y, Wang S, Ahn IS, Tamboline M, Hildreth AD, Larios J, Schcolnik-Cabrera A, Nouhi Z, Zhang Z, Tol MJ, Pandey V, Xu S, O'Sullivan TE, Mack JJ, Tontonoz P, Sallam T, Wohlschlegel JA, Hulea L, Xiao X, Yang X, Villanueva CJ. PMID: 39579770.
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PubMed Mentions: Fields:
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Transcription factor PATZ1 promotes adipogenesis by controlling promoter regulatory loci of adipogenic factors. Nat Commun. 2024 Oct 02; 15(1):8533.
Patel S, Ganbold K, Cho CH, Siddiqui J, Yildiz R, Sparman N, Sadeh S, Nguyen CM, Wang J, Whitelegge JP, Fried SK, Waki H, Villanueva CJ, Seldin MM, Sakaguchi S, Ellmeier W, Tontonoz P, Rajbhandari P. PMID: 39358382; PMCID: PMC11447024.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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A PPARγ/long noncoding RNA axis regulates adipose thermoneutral remodeling in mice. J Clin Invest. 2023 11 01; 133(21).
Zhang Z, Cui Y, Su V, Wang D, Tol MJ, Cheng L, Wu X, Kim J, Rajbhandari P, Zhang S, Li W, Tontonoz P, Villanueva CJ, Sallam T. PMID: 37909330; PMCID: PMC10617768.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. J Lipid Res. 2024 02; 65(2):100434.
Zhang S, Williams KJ, Verlande-Ferrero A, Chan AP, Su GB, Kershaw EE, Cox JE, Maschek JA, Shapira SN, Christofk HR, de Aguiar Vallim TQ, Masri S, Villanueva CJ. PMID: 37640283; PMCID: PMC10839691.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis. Sci Adv. 2023 02 24; 9(8):eade7864.
Johnson JM, Peterlin AD, Balderas E, Sustarsic EG, Maschek JA, Lang MJ, Jara-Ramos A, Panic V, Morgan JT, Villanueva CJ, Sanchez A, Rutter J, Lodhi IJ, Cox JE, Fisher-Wellman KH, Chaudhuri D, Gerhart-Hines Z, Funai K. PMID: 36827367; PMCID: PMC9956115.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis. Nat Metab. 2023 01; 5(1):165-181.
Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. PMID: 36646756; PMCID: PMC9995220.
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PubMed Mentions:
8 Fields:
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Adipose-tissue plasticity in health and disease. Cell. 2022 02 03; 185(3):419-446.
Sakers A, De Siqueira MK, Seale P, Villanueva CJ. PMID: 35120662; PMCID: PMC11152570.
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PubMed Mentions:
236 Fields:
Translation:
HumansAnimalsCells
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When fat talks, the gut listens: IRONing out metabolism. Cell Metab. 2021 08 03; 33(8):1505-1506.
De Siqueira MK, Villanueva CJ. PMID: 34348093.
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Cells
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Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis. Elife. 2020 08 14; 9.
Panic V, Pearson S, Banks J, Tippetts TS, Velasco-Silva JN, Lee S, Simcox J, Geoghegan G, Bensard CL, van Ry T, Holland WL, Summers SA, Cox J, Ducker GS, Rutter J, Villanueva CJ. PMID: 32795388; PMCID: PMC7476754.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Finding a Needle in a Haystack: Identification of a Beige Fat Progenitor. Cell. 2020 08 06; 182(3):537-539.
Villanueva CJ. PMID: 32763184.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. Cell Metab. 2020 02 04; 31(2):284-300.e7.
Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J. PMID: 31813825; PMCID: PMC7004878.
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PubMed Mentions:
73 Fields:
Translation:
AnimalsCells
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Phospholipid methylation regulates muscle metabolic rate through Ca2+ transport efficiency. Nat Metab. 2019 09; 1(9):876-885.
Verkerke ARP, Ferrara PJ, Lin CT, Johnson JM, Ryan TE, Maschek JA, Eshima H, Paran CW, Laing BT, Siripoksup P, Tippetts TS, Wentzler EJ, Huang H, Spangenburg EE, Brault JJ, Villanueva CJ, Summers SA, Holland WL, Cox JE, Vance DE, Neufer PD, Funai K. PMID: 32405618; PMCID: PMC7218817.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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T cell-mediated regulation of the microbiota protects against obesity. Science. 2019 07 26; 365(6451).
Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL. PMID: 31346040; PMCID: PMC7294966.
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PubMed Mentions:
141 Fields:
Translation:
AnimalsCells
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Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism. Genes Dev. 2019 07 01; 33(13-14):747-762.
Pearson S, Loft A, Rajbhandari P, Simcox J, Lee S, Tontonoz P, Mandrup S, Villanueva CJ. PMID: 31123067; PMCID: PMC6601513.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism. Mol Metab. 2019 06; 24:44-63.
Geoghegan G, Simcox J, Seldin MM, Parnell TJ, Stubben C, Just S, Begaye L, Lusis AJ, Villanueva CJ. PMID: 30948248; PMCID: PMC6531814.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease. PLoS Genet. 2019 02; 15(2):e1007970.
Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, O'Connell RM. PMID: 30768595; PMCID: PMC6395003.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood. Dev Cell. 2019 01 28; 48(2):200-214.e6.
Storelli G, Nam HJ, Simcox J, Villanueva CJ, Thummel CS. PMID: 30554999; PMCID: PMC6351194.
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PubMed Mentions:
24 Fields:
Translation:
Animals
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The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E293-E304.
Bond ST, Moody SC, Liu Y, Civelek M, Villanueva CJ, Gregorevic P, Kingwell BA, Hevener AL, Lusis AJ, Henstridge DC, Calkin AC, Drew BG. PMID: 30512991; PMCID: PMC6397360.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals. J Cell Biochem. 2019 03; 120(3):3599-3610.
Chang SH, Yun UJ, Choi JH, Kim S, Lee AR, Lee DH, Seo MJ, Panic V, Villanueva CJ, Song NJ, Park KW. PMID: 30272815; PMCID: PMC6688606.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice. Cell Death Dis. 2018 08 29; 9(9):876.
Song NJ, Chang SH, Kim S, Panic V, Jang BH, Yun UJ, Choi JH, Li Z, Park KM, Yoon JH, Kim S, Yoo JH, Ling J, Thomas K, Villanueva CJ, Li DY, Ahn JY, Ku JM, Park KW. PMID: 30158592; PMCID: PMC6115456.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose. Cell Rep. 2018 07 10; 24(2):312-319.
Karanth S, Adams JD, Serrano MLA, Quittner-Strom EB, Simcox J, Villanueva CJ, Ozcan L, Holland WL, Yost HJ, Vella A, Schlegel A. PMID: 29996093; PMCID: PMC6086569.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Mitochondrial cardiomyopathies feature increased uptake and diminished efflux of mitochondrial calcium. J Mol Cell Cardiol. 2017 12; 113:22-32.
Sommakia S, Houlihan PR, Deane SS, Simcox JA, Torres NS, Jeong MY, Winge DR, Villanueva CJ, Chaudhuri D. PMID: 28962857; PMCID: PMC5652072.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis. Cell Metab. 2017 Sep 05; 26(3):509-522.e6.
Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ. PMID: 28877455; PMCID: PMC5658052.
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PubMed Mentions:
117 Fields:
Translation:
AnimalsCells
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Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules. Exp Mol Med. 2017 07 07; 49(7):e353.
Song NJ, Chang SH, Li DY, Villanueva CJ, Park KW. PMID: 28684864; PMCID: PMC5565954.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. J Clin Invest. 2017 Mar 01; 127(3):987-1004.
Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P. PMID: 28192372; PMCID: PMC5330726.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis. Elife. 2016 09 23; 5.
Kikani CK, Wu X, Paul L, Sabic H, Shen Z, Shakya A, Keefe A, Villanueva C, Kardon G, Graves B, Tantin D, Rutter J. PMID: 27661449; PMCID: PMC5035144.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015 Feb 27; 290(9):5566-81.
Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL. PMID: 25468909; PMCID: PMC4342471.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab. 2013 Mar 05; 17(3):423-35.
Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P. PMID: 23473036; PMCID: PMC3626567.
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PubMed Mentions:
93 Fields:
Translation:
AnimalsCells
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Dynamic and distinct histone modifications modulate the expression of key adipogenesis regulatory genes. Cell Cycle. 2012 Dec 01; 11(23):4310-22.
Zhang Q, Ramlee MK, Brunmeir R, Villanueva CJ, Halperin D, Xu F. PMID: 23085542; PMCID: PMC3552913.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab. 2011 Apr 06; 13(4):413-427.
Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, Wroblewski K, Schmedt C, Chao LC, Boyadjian R, Mandrup S, Hevener A, Saez E, Tontonoz P. PMID: 21459326; PMCID: PMC3089971.
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PubMed Mentions:
88 Fields:
Translation:
AnimalsCells
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Licensing PPARγ to work in macrophages. Immunity. 2010 Nov 24; 33(5):647-9.
Villanueva CJ, Tontonoz P. PMID: 21094459; PMCID: PMC3005613.
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PubMed Mentions:
8 Fields:
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Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. Hepatology. 2009 Aug; 50(2):434-42.
Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV. PMID: 19472314; PMCID: PMC3097135.
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PubMed Mentions:
74 Fields:
Translation:
Animals
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Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Mol Endocrinol. 2008 Dec; 22(12):2596-608.
Chao LC, Bensinger SJ, Villanueva CJ, Wroblewski K, Tontonoz P. PMID: 18945812; PMCID: PMC2610364.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation. Mol Endocrinol. 2008 Sep; 22(9):2038-48.
Park KW, Waki H, Villanueva CJ, Monticelli LA, Hong C, Kang S, MacDougald OA, Goldrath AW, Tontonoz P. PMID: 18562627; PMCID: PMC2631374.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 2008 Sep; 49(9):2038-44.
Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV, Horton JD, Preitner F, Thorens B, Tappy L. PMID: 18515909; PMCID: PMC3837456.
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PubMed Mentions:
78 Fields:
Translation:
Animals
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Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E388-94.
Streeper RS, Koliwad SK, Villanueva CJ, Farese RV. PMID: 16595853; PMCID: PMC1552042.
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PubMed Mentions:
10 Fields:
Translation:
Animals
This graph shows the total number of publications by year. To see the data as text,
click here.
This graph shows the total number of publications by year. To return to the graph,
click here.
| Year | Publications |
|---|
| 2006 | 1 |
| 2008 | 3 |
| 2009 | 1 |
| 2010 | 1 |
| 2011 | 1 |
| 2012 | 1 |
| 2013 | 1 |
| 2014 | 1 |
| 2016 | 1 |
| 2017 | 4 |
| 2018 | 5 |
| 2019 | 6 |
| 2020 | 2 |
| 2021 | 1 |
| 2022 | 1 |
| 2023 | 4 |
| 2024 | 2 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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