Claudio Javier Villanueva

Title(s)Associate Professor, Integrative Biology And Physiology
SchoolCollege of Letters and Science
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    Collapse Research 
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    IRACDA at UCLA
    NIH K12GM106996Sep 1, 2016 - Aug 31, 2026
    Role: Co-Principal Investigator
    Role of TLE3 in the transcriptional regulation of beige adipocytes
    NIH R01DK103930Aug 1, 2015 - Jul 31, 2021
    Role: Principal Investigator
    Transcriptional regulation of beige adipocytes
    NIH R03DK103089Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Transcriptional role of TLE3 in brown adipose tissue development and metabolism
    NIH K01DK097285Mar 1, 2013 - Jan 31, 2016
    Role: Principal Investigator
    Fatty acid metabolism and DGAT1 deficiency
    NIH F31DK065312May 1, 2004 - Apr 30, 2007
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Adipose-tissue plasticity in health and disease. Cell. 2022 02 03; 185(3):419-446. Sakers A, De Siqueira MK, Seale P, Villanueva CJ. PMID: 35120662.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    2. When fat talks, the gut listens: IRONing out metabolism. Cell Metab. 2021 08 03; 33(8):1505-1506. De Siqueira MK, Villanueva CJ. PMID: 34348093.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis. Elife. 2020 08 14; 9. Panic V, Pearson S, Banks J, Tippetts TS, Velasco-Silva JN, Lee S, Simcox J, Geoghegan G, Bensard CL, van Ry T, Holland WL, Summers SA, Cox J, Ducker GS, Rutter J, Villanueva CJ. PMID: 32795388; PMCID: PMC7476754.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    4. Finding a Needle in a Haystack: Identification of a Beige Fat Progenitor. Cell. 2020 08 06; 182(3):537-539. Villanueva CJ. PMID: 32763184.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. Cell Metab. 2020 02 04; 31(2):284-300.e7. Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J. PMID: 31813825; PMCID: PMC7004878.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    6. Phospholipid methylation regulates muscle metabolic rate through Ca2+ transport efficiency. Nat Metab. 2019 09; 1(9):876-885. Verkerke ARP, Ferrara PJ, Lin CT, Johnson JM, Ryan TE, Maschek JA, Eshima H, Paran CW, Laing BT, Siripoksup P, Tippetts TS, Wentzler EJ, Huang H, Spangenburg EE, Brault JJ, Villanueva CJ, Summers SA, Holland WL, Cox JE, Vance DE, Neufer PD, Funai K. PMID: 32405618; PMCID: PMC7218817.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    7. T cell-mediated regulation of the microbiota protects against obesity. Science. 2019 07 26; 365(6451). Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL. PMID: 31346040; PMCID: PMC7294966.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    8. Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism. Genes Dev. 2019 07 01; 33(13-14):747-762. Pearson S, Loft A, Rajbhandari P, Simcox J, Lee S, Tontonoz P, Mandrup S, Villanueva CJ. PMID: 31123067; PMCID: PMC6601513.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    9. Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism. Mol Metab. 2019 06; 24:44-63. Geoghegan G, Simcox J, Seldin MM, Parnell TJ, Stubben C, Just S, Begaye L, Lusis AJ, Villanueva CJ. PMID: 30948248; PMCID: PMC6531814.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    10. Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease. PLoS Genet. 2019 02; 15(2):e1007970. Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, O'Connell RM. PMID: 30768595; PMCID: PMC6395003.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    11. Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood. Dev Cell. 2019 01 28; 48(2):200-214.e6. Storelli G, Nam HJ, Simcox J, Villanueva CJ, Thummel CS. PMID: 30554999; PMCID: PMC6351194.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    12. The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E293-E304. Bond ST, Moody SC, Liu Y, Civelek M, Villanueva CJ, Gregorevic P, Kingwell BA, Hevener AL, Lusis AJ, Henstridge DC, Calkin AC, Drew BG. PMID: 30512991; PMCID: PMC6397360.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals. J Cell Biochem. 2019 03; 120(3):3599-3610. Chang SH, Yun UJ, Choi JH, Kim S, Lee AR, Lee DH, Seo MJ, Panic V, Villanueva CJ, Song NJ, Park KW. PMID: 30272815; PMCID: PMC6688606.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice. Cell Death Dis. 2018 08 29; 9(9):876. Song NJ, Chang SH, Kim S, Panic V, Jang BH, Yun UJ, Choi JH, Li Z, Park KM, Yoon JH, Kim S, Yoo JH, Ling J, Thomas K, Villanueva CJ, Li DY, Ahn JY, Ku JM, Park KW. PMID: 30158592; PMCID: PMC6115456.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose. Cell Rep. 2018 07 10; 24(2):312-319. Karanth S, Adams JD, Serrano MLA, Quittner-Strom EB, Simcox J, Villanueva CJ, Ozcan L, Holland WL, Yost HJ, Vella A, Schlegel A. PMID: 29996093; PMCID: PMC6086569.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Mitochondrial cardiomyopathies feature increased uptake and diminished efflux of mitochondrial calcium. J Mol Cell Cardiol. 2017 12; 113:22-32. Sommakia S, Houlihan PR, Deane SS, Simcox JA, Torres NS, Jeong MY, Winge DR, Villanueva CJ, Chaudhuri D. PMID: 28962857; PMCID: PMC5652072.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    17. Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis. Cell Metab. 2017 Sep 05; 26(3):509-522.e6. Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ. PMID: 28877455; PMCID: PMC5658052.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    18. Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules. Exp Mol Med. 2017 07 07; 49(7):e353. Song NJ, Chang SH, Li DY, Villanueva CJ, Park KW. PMID: 28684864; PMCID: PMC5565954.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    19. RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. J Clin Invest. 2017 Mar 01; 127(3):987-1004. Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P. PMID: 28192372; PMCID: PMC5330726.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    20. Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis. Elife. 2016 09 23; 5. Kikani CK, Wu X, Paul L, Sabic H, Shen Z, Shakya A, Keefe A, Villanueva C, Kardon G, Graves B, Tantin D, Rutter J. PMID: 27661449; PMCID: PMC5035144.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015 Feb 27; 290(9):5566-81. Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL. PMID: 25468909; PMCID: PMC4342471.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    22. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab. 2013 Mar 05; 17(3):423-35. Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P. PMID: 23473036; PMCID: PMC3626567.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    23. Dynamic and distinct histone modifications modulate the expression of key adipogenesis regulatory genes. Cell Cycle. 2012 Dec 01; 11(23):4310-22. Zhang Q, Ramlee MK, Brunmeir R, Villanueva CJ, Halperin D, Xu F. PMID: 23085542; PMCID: PMC3552913.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    24. TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab. 2011 Apr 06; 13(4):413-427. Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, Wroblewski K, Schmedt C, Chao LC, Boyadjian R, Mandrup S, Hevener A, Saez E, Tontonoz P. PMID: 21459326; PMCID: PMC3089971.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    25. Licensing PPARγ to work in macrophages. Immunity. 2010 Nov 24; 33(5):647-9. Villanueva CJ, Tontonoz P. PMID: 21094459; PMCID: PMC3005613.
      View in: PubMed   Mentions: 8     Fields:    
    26. Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. Hepatology. 2009 Aug; 50(2):434-42. Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV. PMID: 19472314; PMCID: PMC3097135.
      View in: PubMed   Mentions: 66     Fields:    Translation:Animals
    27. Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Mol Endocrinol. 2008 Dec; 22(12):2596-608. Chao LC, Bensinger SJ, Villanueva CJ, Wroblewski K, Tontonoz P. PMID: 18945812; PMCID: PMC2610364.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    28. Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation. Mol Endocrinol. 2008 Sep; 22(9):2038-48. Park KW, Waki H, Villanueva CJ, Monticelli LA, Hong C, Kang S, MacDougald OA, Goldrath AW, Tontonoz P. PMID: 18562627; PMCID: PMC2631374.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    29. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 2008 Sep; 49(9):2038-44. Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV, Horton JD, Preitner F, Thorens B, Tappy L. PMID: 18515909; PMCID: PMC3837456.
      View in: PubMed   Mentions: 70     Fields:    Translation:Animals
    30. Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E388-94. Streeper RS, Koliwad SK, Villanueva CJ, Farese RV. PMID: 16595853; PMCID: PMC1552042.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
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